PathWhiz

PathWhiz ID	Pathway	Meta Data
PW127488 View Pathway	drug action Piperacillin Action Pathway Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Piperacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. It is combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam susceptible, β-lactamase generating strains of several bacteria. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Piperacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Piperacillin interferes with an autolysin inhibitor. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: March 16, 2023 at 04:57 Last Updated: March 16, 2023 at 04:57
PW144446 View Pathway	drug action Piperacillin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:39 Last Updated: October 07, 2023 at 13:39
PW127441 View Pathway	drug action Piperaquine Action Pathway Plasmodium falciparum Piperaquine is an antimalarial agent first synthesized in the 1960's and used throughout China. Its use declined in the 1980's as piperaquine resistant strains of Plasmodium falciparum appeared and artemisinin derivatives became available. It has come back into use in combination with the artemisinin derivative Artenimol as part of the combination product Eurartesim. The mechanism of piperaquine inhibition of the haem detoxification pathway is unknown but is expected to be similar to that of Chloroquine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: February 09, 2023 at 11:10 Last Updated: February 09, 2023 at 11:10
PW146703 View Pathway	drug action Piperaquine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:50 Last Updated: October 07, 2023 at 18:50
PW144708 View Pathway	drug action Piperazine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:16 Last Updated: October 07, 2023 at 14:16
PW146107 View Pathway	drug action Piperonyl butoxide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:26 Last Updated: October 07, 2023 at 17:26
PW144365 View Pathway	drug action Pipobroman Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:29 Last Updated: October 07, 2023 at 13:29
PW128414 View Pathway	drug action Pipotiazine Dopamine Antagonist Action Pathway Homo sapiens Pipotiazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects). BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 28, 2023 at 12:40 Last Updated: August 28, 2023 at 12:40
PW145485 View Pathway	drug action Pipotiazine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:55 Last Updated: October 07, 2023 at 15:55
PW176351 View Pathway	metabolic Pipotiazine Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:25 Last Updated: December 07, 2023 at 15:25