PathWhiz

PathWhiz ID	Pathway	Meta Data
PW122347 View Pathway	physiological Synaptic Cleft Template Homo sapiens Examples of horizontally and vertically oriented synaptic clefts at different sizes. For more details (e.g. dimensions) please consult the style guide. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: February 17, 2019 at 21:19 Last Updated: February 17, 2019 at 21:19
PW123925 View Pathway	metabolic Synthesis and Degradation of Ketone Bodies Drosophila melanogaster Ketone bodies are water-soluble compounds that are produced when fatty acids are broken down during metabolism as by-products. They can be used as a source of energy in the heart and the brain and serve as an important energy source during fasting. The use of ketone bodies in the body has two key parts: ketogenesis and ketolysis, both which occur within the mitochondrial matrix. The former is mediated primarily by 2 key enzymes. 3-hydroxy-3-methaglutaryl coenzyme A synthase is involved in the final major regulatory reaction in the process and condenses acetyl CoA to form 3-hydroxy-3-methylglutaryl-CoA. 3-hydroxymethyl-3-methaglutaryl-CoA lyase on the other hand catalyzes the formation of acetoacetic acid from (3S)-hydroxy-3-methylglutaryl-CoA. Ketolysis however, involves two reversible reactions that mediate activation of free acetoacetic acid from acetoacetyl-CoA and creation of acetyl-CoA to be used as energy by the body. The acetoacetate is activated to the acetoacetyl-CoA by the enzyme succinyl-CoA: 3-ketoacid-coenzyme A transferase. Acetyl CoA acetyltransferase (LD24105p) equilibrates the mitochondrial pools of acetoacetyl-CoA and acetyl-CoA. This role means that LD24105p is involved in both ketogenesis and ketolysis. Acetoacetic acid can alternatively be catalyzed by short-chain dehydrogenase/reductase to form (R)-3-hydroxybutyric acid along with NADH. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Christiana Garros Created On: June 09, 2020 at 16:41 Last Updated: June 09, 2020 at 16:41
PW122459 View Pathway	metabolic Synthesis and Degradation of Ketone Bodies Danio rerio BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: April 17, 2019 at 11:10 Last Updated: April 17, 2019 at 11:10
PW122486 View Pathway	metabolic Synthesis and Degradation of Ketone Bodies Xenopus laevis BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: April 29, 2019 at 19:11 Last Updated: April 29, 2019 at 19:11
PW146767 View Pathway	drug action Synthetic camphor Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:59 Last Updated: October 07, 2023 at 18:59
PW176370 View Pathway	metabolic Synthetic camphor Predicted Metabolism Pathway Homo sapiens Metabolites of Synthetic camphor are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:56 Last Updated: December 07, 2023 at 15:56
PW146084 View Pathway	drug action Synthetic Conjugated Estrogens, A Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:22 Last Updated: October 07, 2023 at 17:22
PW146085 View Pathway	drug action Synthetic Conjugated Estrogens, B Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:22 Last Updated: October 07, 2023 at 17:22
PW124287 View Pathway	metabolic Síntesis de ácidos grasos (CV) Homo sapiens Ruta anabólica para generar ácidos grasos a partir de Acetil-CoA BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Created On: October 27, 2020 at 20:53 Last Updated: October 27, 2020 at 20:53
PW124270 View Pathway	metabolic Síntesis de ácidos grasos (CV) error Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Created On: October 23, 2020 at 16:04 Last Updated: October 23, 2020 at 16:04