PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128108 View Pathway	drug action Escitalopram Mechanism of Action Action Pathway New Homo sapiens Escitalopram is the therapeutic active S- enantiomer of citalopram. It is classified as a selective serotonin reuptake inhibitor used to treat depression and anxiety. It's mechanism of action it to bind selectively bind to the sodium dependent serotonin transporter and blocking the recycling of serotonin from the synapse. As serotonin accumulates it restores the serotonergic function of the 5-hydroxytryptamine 1A receptor leading to decreased anxiety and depressive moods. Escitalopram is one of the safest SSRI treatments as it has the highest degree of selectivity for the serotonin transporter (SERT) and therefore doesn't bind to other off-target functions. Following administration, it has a high bio-availability also making it an ideal drug to treat anxiety and depression. It is mainly administered through an oral route in the form of a tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: July 18, 2023 at 13:40 Last Updated: July 18, 2023 at 13:40
PW176366 View Pathway	metabolic Escitalopram Predicted Metabolism Pathway Homo sapiens Metabolites of Escitalopram are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:52 Last Updated: December 07, 2023 at 15:52
PW146594 View Pathway	drug action Esculin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:35 Last Updated: October 07, 2023 at 18:35
PW127856 View Pathway	drug action Esketamine Action Pathway Homo sapiens Esketamine, known by the brand name Spravato, is a NMDA receptor antagonist used for treatment-resistant depression. It is nasal sprayand the s-enantiomer of Ketamine. It is considered a central nervous system depressant agent that can causes sedation, dizziness, lethargy, and it can impair judgment, thinking, reaction speed, and motor skills. It also has side effects on cardiac electrophysiology, blood pressure, and cognition. Esketamine non-selectively and non-competively antagonized the N-methyl-D-aspartate (NMDA) receptor. The exact mechanism by which esketamine acts as an anti-depressant is unknown. The primary metabolite of esketamine, noresketamine, also shows antagonism of the NMDA receptor with a weaker affinity. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: June 09, 2023 at 15:29 Last Updated: June 09, 2023 at 15:29
PW146457 View Pathway	drug action Esketamine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:15 Last Updated: October 07, 2023 at 18:15
PW176382 View Pathway	metabolic Esketamine Predicted Metabolism Pathway Homo sapiens Metabolites of Esketamine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 16:34 Last Updated: December 07, 2023 at 16:34
PW127861 View Pathway	drug action Eslicarbazepine Acetate Action Pathway Homo sapiens Eslicarbazepine acetate is an anticonvulsant agent used as an adjunct to treat partial-onset seizures in patients with inadequate clinical response to conventional antiepileptic therapy. It can be found under the brand names Aptiom and Zebinix. Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled with conventional therapy. Eslicarbazepine acetate is a prodrug that is rapidly converted to eslicarbazepine, the primary active metabolite in the body. Eslicarbazepine's mechanism of action is not well understood, but it is known that it does exert anticonvulsant activity by inhibiting repeated neuronal firing and stabilizing the inactivated state of voltage-gated sodium channels, thus preventing their return to the activated state during which seizure activity can occur. Eslicarbazepine acetate is converted to the active metabolite eslicarbazepine which carries out its anticonvulsant activity. The exact mechanism of action is unknown, but it is thought to involve the inhibition of voltage-gated sodium channels. In in vitro electrophysiological studies, eslicarbazepine was shown to inhibit repeated neuronal firing by stabilizing the inactivated state of voltage-gated sodium channels and preventing their return to the activated state. In vitro studies also showed eslicarbazepine inhibiting T-type calcium channels, which likely also has a role in anticonvulsant activity. Some side effects of using eslicarbazepine acetate may include dizziness, nausea, headache, and aphasia. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Hayley Created On: June 12, 2023 at 09:14 Last Updated: June 12, 2023 at 09:14
PW145991 View Pathway	drug action Eslicarbazepine acetate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:08 Last Updated: October 07, 2023 at 17:08
PW146855 View Pathway	drug action Eslicarbazepine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:12 Last Updated: October 07, 2023 at 19:12
PW176302 View Pathway	metabolic Eslicarbazepine Predicted Metabolism Pathway Homo sapiens Metabolites of Eslicarbazepine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 15:12 Last Updated: December 04, 2023 at 15:12