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PW176537

Pw176537 View Pathway
metabolic

Estriol Predicted Metabolism Pathway

Homo sapiens
Metabolites of Estriol are predicted with biotransformer.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Omolola

Created On: December 13, 2023 at 14:49

Last Updated: December 13, 2023 at 14:49

PW122423

Pw122423 View Pathway
metabolic

Estrogen Metabolism

Homo sapiens
Estrogen, or oestrogen, is the primary female sex hormone. It is responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens in females that have estrogenic hormonal activity: estrone, estradiol, and estriol. The estrane steroid estradiol is the most potent and prevalent of these. The three major naturally occurring forms of estrogen in females are estrone (E1), estradiol (E2), and estriol (E3). Another type of estrogen called estetrol (E4) is produced only during pregnancy. Quantitatively, estrogens circulate at lower levels than androgens in both men and women. While estrogen levels are significantly lower in males compared to females, estrogens nevertheless also have important physiological roles in males.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Guest: Anonymous

Created On: April 04, 2019 at 05:02

Last Updated: April 04, 2019 at 05:02

PW144768

Pw144768 View Pathway
drug action

Estrone Drug Metabolism Action Pathway

Homo sapiens
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ray Kruger

Created On: October 07, 2023 at 14:23

Last Updated: October 07, 2023 at 14:23

PW088441

Pw088441 View Pathway
metabolic

Estrone Metabolism

Drosophila melanogaster
Estrone (also known as oestrone) is a weak endogenous estrogen, a steroid and minor female sex hormone. Estrone is synthesized from cholesterol and secreted from gonads. Endoplasmic reticulum (ER) is the place that estrone undergoes primary metabolism. Estrone sulfate and estrone glucuronide are the conjugated product of estrone; and CYP450 can hydroxylate estrone into catechol estrogens. The enzyme catechol O-methyltransferase catalyzes the conversion of 2-hydroxyestrone into 2-methoxyestrone which is used to synthesize 2-methoxyestrone 3-glucuronide via the membrane-associated massive multimer UDP-glucuronosyltransferase 1-1. Estrone can also be reversibly converted into estradiol by estradiol 17-beta-dehydrogenase 1. This same enzyme can reversibly convert 16a-hydroxyestrone (synthesized from estrone via cytochrome P450 3A5) into estriol. Estriol is alternatively synthesized from estradiol via cytochrome P450 3A5.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ana Marcu

Created On: August 10, 2018 at 16:45

Last Updated: August 10, 2018 at 16:45

PW088384

Pw088384 View Pathway
metabolic

Estrone Metabolism

Rattus norvegicus
Estrone (also known as oestrone) is a weak endogenous estrogen, a steroid and minor female sex hormone. Estrone is synthesized from cholesterol and secreted from gonads. Endoplasmic reticulum (ER) is the place that estrone undergoes primary metabolism. Estrone sulfate and estrone glucuronide are the conjugated product of estrone; and CYP450 can hydroxylate estrone into catechol estrogens. The enzyme catechol O-methyltransferase catalyzes the conversion of 2-hydroxyestrone into 2-methoxyestrone which is used to synthesize 2-methoxyestrone 3-glucuronide via the membrane-associated massive multimer UDP-glucuronosyltransferase 1-1. Estrone can also be reversibly converted into estradiol by estradiol 17-beta-dehydrogenase 1. This same enzyme can reversibly convert 16a-hydroxyestrone (synthesized from estrone via cytochrome P450 3A5) into estriol. Estriol is alternatively synthesized from estradiol via cytochrome P450 3A5.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ana Marcu

Created On: August 10, 2018 at 15:26

Last Updated: August 10, 2018 at 15:26

PW088291

Pw088291 View Pathway
metabolic

Estrone Metabolism

Bos taurus
Estrone (also known as oestrone) is a weak endogenous estrogen, a steroid and minor female sex hormone. Estrone is synthesized from cholesterol and secreted from gonads. Endoplasmic reticulum (ER) is the place that estrone undergoes primary metabolism. Estrone sulfate and estrone glucuronide are the conjugated product of estrone; and CYP450 can hydroxylate estrone into catechol estrogens. The enzyme catechol O-methyltransferase catalyzes the conversion of 2-hydroxyestrone into 2-methoxyestrone which is used to synthesize 2-methoxyestrone 3-glucuronide via the membrane-associated massive multimer UDP-glucuronosyltransferase 1-1. Estrone can also be reversibly converted into estradiol by estradiol 17-beta-dehydrogenase 1. This same enzyme can reversibly convert 16a-hydroxyestrone (synthesized from estrone via cytochrome P450 3A5) into estriol. Estriol is alternatively synthesized from estradiol via cytochrome P450 3A5.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ana Marcu

Created On: August 10, 2018 at 13:14

Last Updated: August 10, 2018 at 13:14

PW088551

Pw088551 View Pathway
metabolic

Estrone Metabolism

Caenorhabditis elegans
Estrone (also known as oestrone) is a weak endogenous estrogen, a steroid and minor female sex hormone. Estrone is synthesized from cholesterol and secreted from gonads. Endoplasmic reticulum (ER) is the place that estrone undergoes primary metabolism. Estrone sulfate and estrone glucuronide are the conjugated product of estrone; and CYP450 can hydroxylate estrone into catechol estrogens. The enzyme catechol O-methyltransferase catalyzes the conversion of 2-hydroxyestrone into 2-methoxyestrone which is used to synthesize 2-methoxyestrone 3-glucuronide via the membrane-associated massive multimer UDP-glucuronosyltransferase 1-1. Estrone can also be reversibly converted into estradiol by estradiol 17-beta-dehydrogenase 1. This same enzyme can reversibly convert 16a-hydroxyestrone (synthesized from estrone via cytochrome P450 3A5) into estriol. Estriol is alternatively synthesized from estradiol via cytochrome P450 3A5.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ana Marcu

Created On: August 10, 2018 at 18:32

Last Updated: August 10, 2018 at 18:32

PW064678

Pw064678 View Pathway
metabolic

Estrone Metabolism

Mus musculus
Estrone (also known as oestrone) is a weak endogenous estrogen, a steroid and minor female sex hormone. Estrone is synthesized from cholesterol and secreted from gonads. Endoplasmic reticulum (ER) is the place that estrone undergoes primary metabolism. Estrone sulfate and estrone glucuronide are the conjugated product of estrone; and CYP450 can hydroxylate estrone into catechol estrogens. The enzyme catechol O-methyltransferase catalyzes the conversion of 2-hydroxyestrone into 2-methoxyestrone which is used to synthesize 2-methoxyestrone 3-glucuronide via the membrane-associated massive multimer UDP-glucuronosyltransferase 1-1. Estrone can also be reversibly converted into estradiol by estradiol 17-beta-dehydrogenase 1. This same enzyme can reversibly convert 16a-hydroxyestrone (synthesized from estrone via cytochrome P450 3A5) into estriol. Estriol is alternatively synthesized from estradiol via cytochrome P450 3A5.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Carin Li

Created On: January 22, 2018 at 00:52

Last Updated: January 22, 2018 at 00:52

PW031778

Pw031778 View Pathway
metabolic

Estrone Metabolism

Homo sapiens
Estrone (also known as oestrone) is a weak endogenous estrogen, a steroid and minor female sex hormone. Estrone is synthesized from cholesterol and secreted from gonads. Endoplasmic reticulum (ER) is the place that estrone undergoes primary metabolism. Estrone sulfate and estrone glucuronide are the conjugated product of estrone; and CYP450 can hydroxylate estrone into catechol estrogens. The enzyme catechol O-methyltransferase catalyzes the conversion of 2-hydroxyestrone into 2-methoxyestrone which is used to synthesize 2-methoxyestrone 3-glucuronide via the membrane-associated massive multimer UDP-glucuronosyltransferase 1-1. Estrone can also be reversibly converted into estradiol by estradiol 17-beta-dehydrogenase 1. This same enzyme can reversibly convert 16a-hydroxyestrone (synthesized from estrone via cytochrome P450 3A5) into estriol. Estriol is alternatively synthesized from estradiol via cytochrome P450 3A5.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Carin Li

Created On: July 21, 2017 at 09:23

Last Updated: July 21, 2017 at 09:23

PW176531

Pw176531 View Pathway
metabolic

Estrone Predicted Metabolism Pathway

Homo sapiens
Metabolites of Estrone are predicted with biotransformer.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Omolola

Created On: December 13, 2023 at 14:26

Last Updated: December 13, 2023 at 14:26