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PathWhiz ID Pathway Meta Data

PW002704

Pw002704 View Pathway
metabolic

Gluconeogenesis 1466284170

Homo sapiens

PW124125

Pw124125 View Pathway
metabolic

Gluconeogenesis 1466284170 1598508425

Homo sapiens

PW002705

Pw002705 View Pathway
metabolic

Gluconeogenesis 1466291909

Homo sapiens

PW124127

Pw124127 View Pathway
metabolic

Gluconeogenesis DP

Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

PW226844

Pw226844 View Pathway
metabolic

Gluconeogenesis eq.2

Homo sapiens

PW000819

Pw000819 View Pathway
metabolic

Gluconeogenesis from L-Malic Acid

Escherichia coli
Gluconeogenesis from L-malic acid starts from the introduction of L-malic acid into cytoplasm either through a C4 dicarboxylate / orotate:H+ symporter or a dicarboxylate transporter (succinic acid antiporter). L-malic acid is then metabolized through 3 possible ways: NAD driven malate dehydrogenase resulting in oxalacetic acid, NADP driven malate dehydrogenase B resulting pyruvic acid or malate dehydrogenase, NAD-requiring resulting in pyruvic acid. Oxalacetic acid is processed by phosphoenolpyruvate carboxykinase (ATP driven) while pyruvic acid is processed by phosphoenolpyruvate synthetase resulting in phosphoenolpyruvic acid. This compound is dehydrated by enolase resulting in an 2-phosphoglyceric acid which is then isomerized by 2,3-bisphosphoglycerate-independent phosphoglycerate mutase resulting in a 3-phosphoglyceric acid which is phosphorylated by an ATP driven phosphoglycerate kinase resulting in a glyceric acid 1,3-biphosphate. This compound undergoes an NADH driven glyceraldehyde 3-phosphate dehydrogenase reaction resulting in a D-Glyceraldehyde 3-phosphate which is first isomerized into dihydroxyacetone phosphate through an triosephosphate isomerase. D-glyceraldehyde 3-phosphate and Dihydroxyacetone phosphate react through a fructose biphosphate aldolase protein complex resulting in a fructose 1,6-biphosphate. Fructose 1,6-biphosphateis is metabolized by a fructose-1,6-bisphosphatase resulting in a Beta-D-fructofuranose 6-phosphate which is then isomerized into a Beta-D-glucose 6-phosphate through a glucose-6-phosphate isomerase.

PW002518

Pw002518 View Pathway
metabolic

Gluconeogenesis from L-Malic Acid

Arabidopsis thaliana
L-malic acid is metabolized through 3 possible ways: NAD driven malate dehydrogenase resulting in oxalacetic acid, NADP driven malate dehydrogenase B resulting pyruvic acid or malate dehydrogenase, NAD-requiring resulting in pyruvic acid. Oxalacetic acid is processed by phosphoenolpyruvate carboxykinase (ATP driven) while pyruvic acid is processed by phosphoenolpyruvate synthetase resulting in phosphoenolpyruvic acid. This compound is dehydrated by enolase resulting in an 2-phosphoglyceric acid. This compound is then isomerized by 2,3-bisphosphoglycerate-independent phosphoglycerate mutase resulting in a 3-phosphoglyceric acid which is phosphorylated by an ATP driven phosphoglycerate kinase resulting in an glyceric acid 1,3-biphosphate. This compound undergoes an NADH driven glyceraldehyde 3-phosphate dehydrogenase reaction resulting in a D-Glyceraldehyde 3-phosphate which is first isomerized into dihydroxyacetone phosphate through an triosephosphate isomerase. D-glyceraldehyde 3-phosphate and Dihydroxyacetone phosphate react through a fructose biphosphate aldolase protein complex resulting in a fructose 1,6-biphosphate. This compound is metabolized by a fructose-1,6-bisphosphatase resulting in a Beta-D-fructofuranose 6-phosphate which is then isomerized into a Beta-D-glucose 6-phosphate through a glucose-6-phosphate isomerase.

PW226859

Pw226859 View Pathway
metabolic

Gluconeogenesis team 2

Homo sapiens
The brain, eye, and kidney are some of the organs that have glucose as the sole metabolic fuel source. Prolonged fasting or vigorous exercise depletes glycogen stores, making the body switch to de-novo glucose synthesis to maintain blood levels of this monosaccharide. Gluconeogenesis is the process that allows the body to form glucose from non-hexose precursors, particularly glycerol, lactate, pyruvate, propionate, and glucogenic amino acids. [Melkonian EA, Asuka E, Schury MP. Physiology, Gluconeogenesis. 2023 Nov 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31082163.]

PW124269

Pw124269 View Pathway
metabolic

Gluconeogénesis (CV)

Homo sapiens

PW146604

Pw146604 View Pathway
drug action

Gluconic Acid Drug Metabolism Action Pathway

Homo sapiens