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PathWhiz ID | Pathway | Meta Data |
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PW002704 |
Gluconeogenesis 1466284170Homo sapiens
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Creator: Guest: Anonymous Created On: June 18, 2016 at 15:09 Last Updated: June 18, 2016 at 15:09 |
PW124125 |
Gluconeogenesis 1466284170 1598508425Homo sapiens
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Creator: Guest: Anonymous Created On: August 27, 2020 at 00:07 Last Updated: August 27, 2020 at 00:07 |
PW002705 |
Gluconeogenesis 1466291909Homo sapiens
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Creator: Guest: Anonymous Created On: June 18, 2016 at 17:18 Last Updated: June 18, 2016 at 17:18 |
PW124127 |
Gluconeogenesis DPAcinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
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Creator: Guest: Anonymous Created On: August 27, 2020 at 00:19 Last Updated: August 27, 2020 at 00:19 |
PW226844 |
Gluconeogenesis eq.2Homo sapiens
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Creator: Guest: Anonymous Created On: March 18, 2024 at 15:43 Last Updated: March 18, 2024 at 15:43 |
PW000819 |
Gluconeogenesis from L-Malic AcidEscherichia coli
Gluconeogenesis from L-malic acid starts from the introduction of L-malic acid into cytoplasm either through a C4 dicarboxylate / orotate:H+ symporter or a dicarboxylate transporter (succinic acid antiporter). L-malic acid is then metabolized through 3 possible ways: NAD driven malate dehydrogenase resulting in oxalacetic acid, NADP driven malate dehydrogenase B resulting pyruvic acid or malate dehydrogenase, NAD-requiring resulting in pyruvic acid.
Oxalacetic acid is processed by phosphoenolpyruvate carboxykinase (ATP driven) while pyruvic acid is processed by phosphoenolpyruvate synthetase resulting in phosphoenolpyruvic acid. This compound is dehydrated by enolase resulting in an 2-phosphoglyceric acid which is then isomerized by 2,3-bisphosphoglycerate-independent phosphoglycerate mutase resulting in a 3-phosphoglyceric acid which is phosphorylated by an ATP driven phosphoglycerate kinase resulting in a glyceric acid 1,3-biphosphate. This compound undergoes an NADH driven glyceraldehyde 3-phosphate dehydrogenase reaction resulting in a D-Glyceraldehyde 3-phosphate which is first isomerized into dihydroxyacetone phosphate through an triosephosphate isomerase. D-glyceraldehyde 3-phosphate and Dihydroxyacetone phosphate react through a fructose biphosphate aldolase protein complex resulting in a fructose 1,6-biphosphate. Fructose 1,6-biphosphateis is metabolized by a fructose-1,6-bisphosphatase resulting in a Beta-D-fructofuranose 6-phosphate which is then isomerized into a Beta-D-glucose 6-phosphate through a glucose-6-phosphate isomerase.
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Creator: miguel ramirez Created On: March 24, 2015 at 13:00 Last Updated: March 24, 2015 at 13:00 |
PW002518 |
Gluconeogenesis from L-Malic AcidArabidopsis thaliana
L-malic acid is metabolized through 3 possible ways: NAD driven malate dehydrogenase resulting in oxalacetic acid, NADP driven malate dehydrogenase B resulting pyruvic acid or malate dehydrogenase, NAD-requiring resulting in pyruvic acid. Oxalacetic acid is processed by phosphoenolpyruvate carboxykinase (ATP driven) while pyruvic acid is processed by phosphoenolpyruvate synthetase resulting in phosphoenolpyruvic acid. This compound is dehydrated by enolase resulting in an 2-phosphoglyceric acid. This compound is then isomerized by 2,3-bisphosphoglycerate-independent phosphoglycerate mutase resulting in a 3-phosphoglyceric acid which is phosphorylated by an ATP driven phosphoglycerate kinase resulting in an glyceric acid 1,3-biphosphate. This compound undergoes an NADH driven glyceraldehyde 3-phosphate dehydrogenase reaction resulting in a D-Glyceraldehyde 3-phosphate which is first isomerized into dihydroxyacetone phosphate through an triosephosphate isomerase. D-glyceraldehyde 3-phosphate and Dihydroxyacetone phosphate react through a fructose biphosphate aldolase protein complex resulting in a fructose 1,6-biphosphate. This compound is metabolized by a fructose-1,6-bisphosphatase resulting in a Beta-D-fructofuranose 6-phosphate which is then isomerized into a Beta-D-glucose 6-phosphate through a glucose-6-phosphate isomerase.
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Creator: miguel ramirez Created On: April 06, 2016 at 15:55 Last Updated: April 06, 2016 at 15:55 |
PW226859 |
Gluconeogenesis team 2Homo sapiens
The brain, eye, and kidney are some of the organs that have glucose as the sole metabolic fuel source. Prolonged fasting or vigorous exercise depletes glycogen stores, making the body switch to de-novo glucose synthesis to maintain blood levels of this monosaccharide. Gluconeogenesis is the process that allows the body to form glucose from non-hexose precursors, particularly glycerol, lactate, pyruvate, propionate, and glucogenic amino acids. [Melkonian EA, Asuka E, Schury MP. Physiology, Gluconeogenesis. 2023 Nov 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31082163.]
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Creator: Guest: Anonymous Created On: March 18, 2024 at 16:07 Last Updated: March 18, 2024 at 16:07 |
PW124269 |
Gluconeogénesis (CV)Homo sapiens
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Creator: Valeria Created On: October 23, 2020 at 15:54 Last Updated: October 23, 2020 at 15:54 |
PW146604 |
drug action
Gluconic Acid Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 18:37 Last Updated: October 07, 2023 at 18:37 |