PathWhiz

PathWhiz ID	Pathway	Meta Data
PW120522 View Pathway	signaling OX40 Signaling Pathway Homo sapiens OX40 is a type 1 transmembrane glycoprotein, reported nearly 30 years ago as a cell surface antigen expressed on activated T cells. Since its discovery, it has been validated as a bone fide costimulatory molecule for T cells and member of the TNF receptor family. Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a fellow of the TNFR-superfamily of receptors. It is a protein which in humans is encoded by the TNFRSF4 gene which contains 9 exons. It also has been demonstrated to have a key role in the survival and homeostasis of effector and memory T cells in transplantation and autoimmunity. OX40 is not constitutively expressed on resting naive T cells, unlike CD28. As a secondary co-stimulatory immune checkpoint molecule, it expresses after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells and resting naive T cells, but is following their activation. Expression of OX40 is dependent on full activation of the T cell and the expression of CD28; without CD28, expression of OX40 is delayed and of fourfold lower levels. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Aidin Foroutannaddafi Created On: September 07, 2018 at 19:53 Last Updated: September 07, 2018 at 19:53
PW127494 View Pathway	drug action Oxacillin Action Pathway Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Oxacillin is a penicillin antibiotic used to treat a number of susceptible bacterial infections. Oxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Oxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Oxacillin interferes with an autolysin inhibitor. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: March 20, 2023 at 03:22 Last Updated: March 20, 2023 at 03:22
PW144825 View Pathway	drug action Oxacillin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:30 Last Updated: October 07, 2023 at 14:30
PW132200 View Pathway	metabolic Oxaliplatin Drug Metabolism Homo sapiens Oxaliplatin is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Oxaliplatin passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:05 Last Updated: September 21, 2023 at 20:05
PW144644 View Pathway	drug action Oxaliplatin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:06 Last Updated: October 07, 2023 at 14:06
PW145186 View Pathway	drug action Oxamniquine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:16 Last Updated: October 07, 2023 at 15:16
PW176280 View Pathway	metabolic Oxamniquine Predicted Metabolism Pathway Homo sapiens Metabolites of Oxamniquine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 14:35 Last Updated: December 04, 2023 at 14:35
PW132516 View Pathway	metabolic Oxandrolone Drug Metabolism Homo sapiens Oxandrolone is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Oxandrolone passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:13 Last Updated: September 21, 2023 at 22:13
PW144735 View Pathway	drug action Oxandrolone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:19 Last Updated: October 07, 2023 at 14:19
PW000262 View Pathway	drug action Oxaprozin Action Pathway Homo sapiens Oxaprozin (also named Daypro, Dayrun) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used to relieve pain (analgesic) and reduce fever (antipyretic). Oxaprozin is also a type of ophthalmic anti-inflammatory medicines which may be used to help prevent eye constrict for pupil during surgery. Oxaprozin can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. Since prostaglandin is the messenger molecules in the process of inflammation; hence, inhibition of prostaglandin synthesis can reduce the pain and inflammation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45