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PW122549

Pw122549 View Pathway
metabolic

tca

Aeromonas media WS
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Creator: Guest: Anonymous

Created On: July 30, 2019 at 05:29

Last Updated: July 30, 2019 at 05:29

PW123644

Pw123644 View Pathway
metabolic

TCA

Klebsiella pneumoniae
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Creator: Guest: Anonymous

Created On: November 09, 2019 at 13:47

Last Updated: November 09, 2019 at 13:47

PW124445

Pw124445 View Pathway
metabolic

TCA

Escherichia coli
The name of this metabolic pathway is derived from the citric acid (a tricarboxylic acid, often called citrate, as the ionized form predominates at biological pH[6]) that is consumed and then regenerated by this sequence of reactions to complete the cycle. The cycle consumes acetate (in the form of acetyl-CoA) and water, reduces NAD+ to NADH, releasing carbon dioxide. The NADH generated by the citric acid cycle is fed into the oxidative phosphorylation (electron transport) pathway. The net result of these two closely linked pathways is the oxidation of nutrients to produce usable chemical energy in the form of ATP.
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Creator: Guest: Anonymous

Created On: January 13, 2021 at 12:42

Last Updated: January 13, 2021 at 12:42

PW122267

Pw122267 View Pathway
metabolic

TCA and aminoacids

Saccharomyces cerevisiae
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Creator: Guest: Anonymous

Created On: October 25, 2018 at 11:59

Last Updated: October 25, 2018 at 11:59

PW122301

Pw122301 View Pathway
metabolic

TCA Cycle

Mus musculus
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Creator: Bisheng Zhou

Created On: November 21, 2018 at 19:54

Last Updated: November 21, 2018 at 19:54

PW270586

Pw270586 View Pathway
metabolic

TCA Cycle

Pseudomonas putida
The citric acid cycle (also named tricarboxylic acid (TCA) cycle or the Krebs cycle), is a collection of 9 enzyme-catalyzed chemical reactions that occur in all living cells undergoing aerobic respiration. The citric acid cycle itself was officially identified in 1937 by Hans Adolf Krebs, who received the Nobel Prize for this discovery in 1953. In eukaryotes, the citric acid cycle occurs in the mitochondria. In prokaryotes, the TCA cycle occurs in the cytoplasm. The TCA cycle starts with acetyl-CoA, which is the “fuel” for the entire cycle. This important molecule comes from the breakdown of glycogen (a stored form of glucose), fats, and many amino acids. At beginning, acetyl-CoA first transfers its 2-carbon acetyl group to the 4-carbon acceptor compound called oxaloacetate to form the 6-carbon compound (citrate) for which the cycle is named. The resulting citrate will have numbers of chemical transformations, whereby it loses one carboxyl group (leading to the 5-carbon compound called alpha-ketoglutarate) and then a second carboxyl group (leading to the 4-carbon compound called succinate). Succinate molecule is further oxidized to fumarate, then malate and finally oxaloacetate. The regeneration of the 4-carbon oxaloacetate, allows the TCA cycle to continue. Oxidation step generates energy that is transferring energy-rich electrons for NAD+ to form NADH in TCA cycle. Each acetyl group will generate 3 NADH in TCA cycle.
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Creator: Julia Wakoli

Created On: June 10, 2024 at 18:30

Last Updated: June 10, 2024 at 18:30

PW270365

Pw270365 View Pathway
metabolic

TCA Cycle

Pseudoxanthomonas spadix
The citric acid cycle (also named tricarboxylic acid (TCA) cycle or the Krebs cycle), is a collection of 9 enzyme-catalyzed chemical reactions that occur in all living cells undergoing aerobic respiration. The citric acid cycle itself was officially identified in 1937 by Hans Adolf Krebs, who received the Nobel Prize for this discovery in 1953. In eukaryotes, the citric acid cycle occurs in the mitochondria. In prokaryotes, the TCA cycle occurs in the cytoplasm. The TCA cycle starts with acetyl-CoA, which is the “fuel” for the entire cycle. This important molecule comes from the breakdown of glycogen (a stored form of glucose), fats, and many amino acids. At beginning, acetyl-CoA first transfers its 2-carbon acetyl group to the 4-carbon acceptor compound called oxaloacetate to form the 6-carbon compound (citrate) for which the cycle is named. The resulting citrate will have numbers of chemical transformations, whereby it loses one carboxyl group (leading to the 5-carbon compound called alpha-ketoglutarate) and then a second carboxyl group (leading to the 4-carbon compound called succinate). Succinate molecule is further oxidized to fumarate, then malate and finally oxaloacetate. The regeneration of the 4-carbon oxaloacetate, allows the TCA cycle to continue. Oxidation step generates energy that is transferring energy-rich electrons for NAD+ to form NADH in TCA cycle. Each acetyl group will generate 3 NADH in TCA cycle.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: June 10, 2024 at 16:55

Last Updated: June 10, 2024 at 16:55

PW002377

Pw002377 View Pathway
metabolic

TCA Cycle

Saccharomyces cerevisiae
Citric acid cycle (also known as tricarboxylic acid cycle (TCA) and Krebs cycle) contains series of reactions that involved enzyme catalyzation which are essential for all living cells that require oxygen for cellular respiration. In mitochondria (for eukaryotes), TCA cycle begins with acetyl-CoA and oxaloacetic acid (oxaloacetate) be catalyzed to form citric acid (citrate) by citrate synthase 3. Then, 3-isopropylmalate dehydratase with cofactor 4Fe-4S can catalyze citrate to form cis-aconitic acid as the intermediate compound and catalyze cis-aconitic acid to form isocitric acid. Many TCA cycle intermediates are the precursors for other molecules' synthesis; and NADH (from NAD+) is the major energy that is produced by oxidative steps of the TCA cycle.
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Creator: miguel ramirez

Created On: December 08, 2015 at 11:50

Last Updated: December 08, 2015 at 11:50

PW122577

Pw122577 View Pathway
metabolic

TCA Cycle

Pseudomonas aeruginosa
The citric acid cycle (also named tricarboxylic acid (TCA) cycle or the Krebs cycle), is a collection of 9 enzyme-catalyzed chemical reactions that occur in all living cells undergoing aerobic respiration. The citric acid cycle itself was officially identified in 1937 by Hans Adolf Krebs, who received the Nobel Prize for this discovery in 1953. In eukaryotes, the citric acid cycle occurs in the mitochondria. In prokaryotes, the TCA cycle occurs in the cytoplasm. The TCA cycle starts with acetyl-CoA, which is the “fuel” for the entire cycle. This important molecule comes from the breakdown of glycogen (a stored form of glucose), fats, and many amino acids. At beginning, acetyl-CoA first transfers its 2-carbon acetyl group to the 4-carbon acceptor compound called oxaloacetate to form the 6-carbon compound (citrate) for which the cycle is named. The resulting citrate will have numbers of chemical transformations, whereby it loses one carboxyl group (leading to the 5-carbon compound called alpha-ketoglutarate) and then a second carboxyl group (leading to the 4-carbon compound called succinate). Succinate molecule is further oxidized to fumarate, then malate and finally oxaloacetate. The regeneration of the 4-carbon oxaloacetate, allows the TCA cycle to continue. Oxidation step generates energy that is transferring energy-rich electrons for NAD+ to form NADH in TCA cycle. Each acetyl group will generate 3 NADH in TCA cycle.
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Creator: Ana Marcu

Created On: August 12, 2019 at 16:59

Last Updated: August 12, 2019 at 16:59

PW124079

Pw124079 View Pathway
metabolic

TCA Cycle

Meloidogyne incognita
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Creator: Guest: Anonymous

Created On: August 14, 2020 at 15:03

Last Updated: August 14, 2020 at 15:03