PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128118 View Pathway	drug action Tocainide Sodium Channel Cardiac Muscle Relaxation Action Pathway Homo sapiens Tocainide is an orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias. It is used to treat conditions including sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.Tocainide binds preferentially to the inactive state of the sodium channels. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers. It also possesses some anticholinergic and local anesthetic properties. Side effects of tocainide include nausea, vomiting, headaches, feeling dizzy, or feeling hot and flushed. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Hayley Created On: July 19, 2023 at 14:51 Last Updated: July 19, 2023 at 14:51
PW146412 View Pathway	drug action Tocofersolan Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:08 Last Updated: October 07, 2023 at 18:08
PW146319 View Pathway	drug action Tocopherol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:55 Last Updated: October 07, 2023 at 17:55
PW145874 View Pathway	drug action Tofacitinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:52 Last Updated: October 07, 2023 at 16:52
PW176479 View Pathway	metabolic Tofacitinib Predicted Metabolism Pathway Homo sapiens Metabolites of Tofacitinib are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 12, 2023 at 16:21 Last Updated: December 12, 2023 at 16:21
PW127726 View Pathway	drug action Tolazamide Action Pathway Homo sapiens Tolazamide is an hypoglycemic agent from the sulfonylurea class used in the treatment of non insulin dependent diabetes mellitus type II. Tolazamide lowers blood glucose by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. This drug binds to ATP-sensitive potassium-channel receptors on the pancreatic cell surface (known as the sulfonylurea receptor 1 (SUR1) subunit (Kir6.2)), reducing potassium conductance and causing depolarization of the membrane. This depolarization stimulates the calcium ion influx through voltage-sensitive calcium channels thus raising intracellular concentrations of calcium ions. The higher concentration of intracellular calcium ions induces the secretion (exocytosis) of insulin into the blood. Tolazamide is administered as an oral tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: May 26, 2023 at 12:05 Last Updated: May 26, 2023 at 12:05
PW144944 View Pathway	drug action Tolazamide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:46 Last Updated: October 07, 2023 at 14:46
PW176149 View Pathway	metabolic Tolazamide Predicted Metabolism Pathway new Homo sapiens Metabolites of Tolazamide are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 14:20 Last Updated: November 29, 2023 at 14:20
PW132365 View Pathway	metabolic Tolazoline Drug Metabolism Homo sapiens Tolazoline is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Tolazoline passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:14 Last Updated: September 21, 2023 at 21:14
PW144904 View Pathway	drug action Tolazoline Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:40 Last Updated: October 07, 2023 at 14:40