PathWhiz

PathWhiz ID	Pathway	Meta Data
PW175989 View Pathway	metabolic Carbetocin Predicted Metabolism Pathway new Homo sapiens Metabolites of Carbetocin are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 13:03 Last Updated: November 29, 2023 at 13:03
PW145357 View Pathway	drug action Carbetocin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:38 Last Updated: October 07, 2023 at 15:38
PW176504 View Pathway	metabolic Carbenicillin Predicted Metabolism Pathway Homo sapiens Metabolites of Carbenicillin are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 13, 2023 at 12:57 Last Updated: December 13, 2023 at 12:57
PW144695 View Pathway	drug action Carbenicillin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:14 Last Updated: October 07, 2023 at 14:14
PW176931 View Pathway	drug action Carbenicillin Action Pathway Escherichia coli Carbenicillin is a broad-spectrum semisynthetic penicillin derivative used parenterally. Carbenicillin exhibits anti-bacterial actions. It works by binding to and inhibiting bacterial penicillin-binding proteins (PBPs) Upon binding to PBPs, ertapenem inhibits bacterial cell wall synthesis by interfering with the lengthening and strengthening of the peptidoglycan portion of the cell wall, thereby inhibiting cell wall synthesis. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: January 02, 2024 at 09:15 Last Updated: January 02, 2024 at 09:15
PW128332 View Pathway	drug action Carbaryl Action Pathway Homo sapiens Carbaryl is an insecticide in addition to a cholinesterase inhibitor it is used as a treatment to remove head lice. It acts on insects and due to its relative dosage compared to a human, the lice having their acetylcholinesterase inhibited leading to muscle spasm and eventually death. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 21, 2023 at 17:04 Last Updated: August 21, 2023 at 17:04
PW123936 View Pathway	metabolic Carbapenem Biosynthesis Streptomyces cattleya Carbapenems are one of the five groups of the beta-lactam family of antibiotics and are currently the most important in clinical use in their broad specificity and resistance to B-lactamase enzymes. They contain an unsaturated, five-carbon ring fused to the nitrogen and carbon of the four-carbon β-lactam ring and act well against both Gram-positive and Gram-negative bacteria. This pathway shows the synthesis of several carbapenems in the bacterium Streptomyces cattleya and this is apparent from the fact that carbapenems are produced by Streptomyces. The pathway begins with the conversion of L-glutamate-5-semialdehyde (from L-Glutamic acid) and its cyclized form 1-Pyrroline-5-carboxylic acid along with the co-substrate malonyl-CoA into 2S,5S)-5-carboxymethyl proline. This intermediate is then converted into ((3S,5S)-carbapenam-3-carboxylate via the enzyme putative beta-lactam synthetase which is then epimerized and desaturated by carbapenem synthase to form the main product of this pathway: (5R)-Carbapenem-3-carboxylate. Stemming from this product, carbapenem biosynthesis intermediates 1-6 act as intermediates which lead to the synthesis of several variations of compounds that belong to the carbapenem family: thienamycin, N-acetylthienamycin, MM 4550 (a member of the olivanic acids and is the major carbapenem produced by S. argenteolus). It must be noted that the lack of direct connections between compounds in this illustration of the pathway accounts for the hypotheticality of the gene products in the reactions that connect one intermediate to the next. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Aadhavya Sivakumaran Created On: June 17, 2020 at 15:36 Last Updated: June 17, 2020 at 15:36
PW121938 View Pathway	disease Carbamoyl Phosphate Synthetase Deficiency Rattus norvegicus CCarbamoyl Phosphate Synthetase Deficiency, also called hyperammonemia due to carbamoyl phosphate synthetase 1 deficiency, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of the urea cycle caused by a defective CPS1 gene. The CPS1 gene codes for the protein carbamoyl phosphate synthetase I, which plays a role in the urea cycle. This disorder is characterized by a large accumulation of ammonia in the blood. Symptoms of the disorder include unusual movements, seizures, unusual sleeping or coma. Treatment with citrulline or arginine, which maintains a regular rate of protein creation. It is estimated that carbamoyl phosphate synthetase deficiency affects 1 in 800,000 individuals in Japan. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:51 Last Updated: September 10, 2018 at 15:51
PW000191 View Pathway	disease Carbamoyl Phosphate Synthetase Deficiency Homo sapiens CCarbamoyl Phosphate Synthetase Deficiency, also called hyperammonemia due to carbamoyl phosphate synthetase 1 deficiency, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of the urea cycle caused by a defective CPS1 gene. The CPS1 gene codes for the protein carbamoyl phosphate synthetase I, which plays a role in the urea cycle. This disorder is characterized by a large accumulation of ammonia in the blood. Symptoms of the disorder include unusual movements, seizures, unusual sleeping or coma. Treatment with citrulline or arginine, which maintains a regular rate of protein creation. It is estimated that carbamoyl phosphate synthetase deficiency affects 1 in 800,000 individuals in Japan. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 19, 2013 at 12:05 Last Updated: August 19, 2013 at 12:05
PW121713 View Pathway	disease Carbamoyl Phosphate Synthetase Deficiency Mus musculus CCarbamoyl Phosphate Synthetase Deficiency, also called hyperammonemia due to carbamoyl phosphate synthetase 1 deficiency, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of the urea cycle caused by a defective CPS1 gene. The CPS1 gene codes for the protein carbamoyl phosphate synthetase I, which plays a role in the urea cycle. This disorder is characterized by a large accumulation of ammonia in the blood. Symptoms of the disorder include unusual movements, seizures, unusual sleeping or coma. Treatment with citrulline or arginine, which maintains a regular rate of protein creation. It is estimated that carbamoyl phosphate synthetase deficiency affects 1 in 800,000 individuals in Japan. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:49 Last Updated: September 10, 2018 at 15:49