PathWhiz

PathWhiz ID	Pathway	Meta Data
PW145116 View Pathway	drug action Guanfacine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:07 Last Updated: October 07, 2023 at 15:07
PW176062 View Pathway	metabolic Guanfacine Predicted Metabolism Pathway new Homo sapiens Metabolites of Guanfacine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 13:39 Last Updated: November 29, 2023 at 13:39
PW132161 View Pathway	metabolic Guanidine Drug Metabolism Homo sapiens Guanidine is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Guanidine passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 19:46 Last Updated: September 21, 2023 at 19:46
PW144654 View Pathway	drug action Guanidine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:08 Last Updated: October 07, 2023 at 14:08
PW127192 View Pathway	disease Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Homo sapiens Guanidinoacetate Methyltransferase Deficiency (Creatine-Deficiency-Syndrome) is a rare autosomal recessive disease caused by a mutation in the GAMT gene which codes for guanidinoacetate N-methyltransferase. A deficiency in this enzyme results in accumulation of 3-methylglutaconic acid in urine; guanidoacetic acid in urine and serum. Decreased concentrations of creatine are found in serum and urine; and creatinine in plasma, spinal fluid, and urine. Symptoms, which present at birth, include failure to thrive, mental and motor retardation, hyoptonia, and seizures. Treatment includes arginine-restricted diet, sodium benzoate, and L-ornithine hydrochlorate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: November 04, 2022 at 11:08 Last Updated: November 04, 2022 at 11:08
PW121969 View Pathway	disease Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Rattus norvegicus Guanidinoacetate Methyltransferase Deficiency (Creatine-Deficiency-Syndrome) is a rare autosomal recessive disease caused by a mutation in the GAMT gene which codes for guanidinoacetate N-methyltransferase. A deficiency in this enzyme results in accumulation of 3-methylglutaconic acid in urine; guanidoacetic acid in urine and serum. Decreased concentrations of creatine are found in serum and urine; and creatinine in plasma, spinal fluid, and urine. Symptoms, which present at birth, include failure to thrive, mental and motor retardation, hyoptonia, and seizures. Treatment includes arginine-restricted diet, sodium benzoate, and L-ornithine hydrochlorate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:51 Last Updated: September 10, 2018 at 15:51
PW000088 View Pathway	disease Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Homo sapiens Guanidinoacetate Methyltransferase Deficiency (Creatine-Deficiency-Syndrome) is a rare autosomal recessive disease caused by a mutation in the GAMT gene which codes for guanidinoacetate N-methyltransferase. A deficiency in this enzyme results in accumulation of 3-methylglutaconic acid in urine; guanidoacetic acid in urine and serum. Decreased concentrations of creatine are found in serum and urine; and creatinine in plasma, spinal fluid, and urine. Symptoms, which present at birth, include failure to thrive, mental and motor retardation, hyoptonia, and seizures. Treatment includes arginine-restricted diet, sodium benzoate, and L-ornithine hydrochlorate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 01, 2013 at 15:52 Last Updated: August 01, 2013 at 15:52
PW121744 View Pathway	disease Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Mus musculus Guanidinoacetate Methyltransferase Deficiency (Creatine-Deficiency-Syndrome) is a rare autosomal recessive disease caused by a mutation in the GAMT gene which codes for guanidinoacetate N-methyltransferase. A deficiency in this enzyme results in accumulation of 3-methylglutaconic acid in urine; guanidoacetic acid in urine and serum. Decreased concentrations of creatine are found in serum and urine; and creatinine in plasma, spinal fluid, and urine. Symptoms, which present at birth, include failure to thrive, mental and motor retardation, hyoptonia, and seizures. Treatment includes arginine-restricted diet, sodium benzoate, and L-ornithine hydrochlorate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:49 Last Updated: September 10, 2018 at 15:49
PW686340 View Pathway	metabolic Guanine and Guanosine Salvage Neisseria elongata subsp. glycolytica ATCC 29315 Guanosine can be converted into guanine through a phosphate driven guanosine phosphorylase resulting in the release of an alpha-D-ribose 1 phosphate and a guanine. This compound in turn reacts with a PRPP through a guanine phosphoribosyltransferase resulting in the release of a pyrophosphate and a GMP. Guanosine can also react with and ATP driven guanosine kinase resulting in the release of an ADP, s hydrogen ion and a GMP BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: February 09, 2025 at 15:58 Last Updated: February 09, 2025 at 15:58
PW512387 View Pathway	metabolic Guanine and Guanosine Salvage Citrobacter amalonaticus Y19 Guanosine can be converted into guanine through a phosphate driven guanosine phosphorylase resulting in the release of an alpha-D-ribose 1 phosphate and a guanine. This compound in turn reacts with a PRPP through a guanine phosphoribosyltransferase resulting in the release of a pyrophosphate and a GMP. Guanosine can also react with and ATP driven guanosine kinase resulting in the release of an ADP, s hydrogen ion and a GMP BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: February 09, 2025 at 18:39 Last Updated: February 09, 2025 at 18:39