PathWhiz

PathWhiz ID	Pathway	Meta Data
PW124162 View Pathway	disease bla Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: September 15, 2020 at 04:24 Last Updated: September 15, 2020 at 04:24
PW000299 View Pathway	drug action Bivalirudin. Homo sapiens Bivalirudin, trade name angiomax, is a direct thrombin inhibitor. It is often prescribed to patients who cannot take unfractionated or low molecular weight heparin. Bivalirudin does not need cofactor antithrobin to act. It binds circulating and clot-bound thrombin at the catalytic site and the anion binding exosite. The inhibition of fibrin prevents the cleavage of fibrinogen into fibrin which activates Factor XIII and Factor XIIIa. This destabilizes the thrombus and inhibits the promotion of thrombin production and platelet activation. As a result, bivalirudin prevents or reduces clot formation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW124113 View Pathway	drug action Bivalirudin Mechanism of Action Action Pathway Homo sapiens Bivalirudin is a synthetic peptide thrombin inhibitor that binds reversibly to the catalytic site and anion-binding exosite inhibiting the cleavage of fibrinogen into fibrin. Bivalirudin is used to treat heparin-induced thrombocytopenia as well as to prevent thrombosis. It is used in patients that are undergoing percutaneous coronary intervention or who have a risk in acute coronary syndromes caused by unstable angina or non-ST segment elevation. Thrombin is an important proteinase as it cleaves fibrinogen into fibrin monomers which help form the thrombus that forms the clot at the site of vascular injury. Because bivalirudin inhibits thrombin, clotting cannot form which is ideal for heart surgeries and some heart conditions. Bivalirudin should be monitored as it inhibits clotting so other injuries won't clot and it also can cause blood stagnation. Monitoring changes in hematocrit and blood pressure is extremely important when taking this drug. It is normally administered intravenously so that it is delivered to the site of action right away and can be controlled more easily. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Kristen Yee Created On: August 24, 2020 at 11:00 Last Updated: August 24, 2020 at 11:00
PW144252 View Pathway	drug action Bivalirudin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:01 Last Updated: October 07, 2023 at 13:01
PW128039 View Pathway	drug action Bivalirudin Action Pathway Homo sapiens Bivalirudin is a direct thrombin inhibitor that treats heparin-induced thrombocytopenia and prevents thrombosis. It binds reversibly to the active site of thrombin inhibiting its activation of fibrinogen and coagulation factor XIII. Without the conversion of fibrinogen into fibrin the formation of a thrombus is stopped. Inactivation of coagulation factor XIII further inhibits blood clot formation, as this factor is responsible for stabilizing cross-linking fibrin creating the meshwork for the clot. This drug is commonly administered intravenously and is metabolized by proteolytic cleavage. Bivalirudin is cleared from plasma by the renal system and proteolytic cleavage. This drug interacts with food, echinacea needs to be avoided in addition to herbs and supplements that have anticoagulant and antiplatelet activity. These herbs and supplements include ginger, garlic, bilberry, danshen, piracetam and ginkgo biloba. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: July 06, 2023 at 10:47 Last Updated: July 06, 2023 at 10:47
PW122445 View Pathway	drug action Bivalirudin Action Homo sapiens Bivalirudin, marketed as Angiomax or Angiox, is a bivalent direct thrombin inhibitor that binds directly to the active site of thrombin, as well as its exosite. It is synthetically created, and is structurally similar to the drug hirudin, which is found in medicinal leeches. It is used in preventing coagulation and formation of blood clots due to the inactivation of the enzyme that catalyzes activation of coagulation factors V, XIII and fibrinogen. Bivalirudin is a reversible direct thrombin inhibitor, as over time, thrombin can cleave the bonds between it and bivalirudin, allowing it to become active again. After injection, bivalirudin enters the blood stream and directly binds to thrombin, preventing its use as an enzyme. This prevents catalyzation of factor V to factor Va, which would form the prothrombinase complex and create more thrombin. It also prevents the catalysis fibrinogen or factor I to fibrin, which then polymerizes to form the blood clot. The lack of useable thrombin also prevents the catalysis of factor XIII to factor XIIIa, which is necessary to crosslink the polymerized fibrin to form a water insoluble clot. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: April 10, 2019 at 20:54 Last Updated: April 10, 2019 at 20:54
PW145573 View Pathway	drug action Bithionol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:06 Last Updated: October 07, 2023 at 16:06
PW132410 View Pathway	metabolic Bithionol Drug Metabolism Homo sapiens Bithionol is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Bithionol passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:33 Last Updated: September 21, 2023 at 21:33
PW176482 View Pathway	metabolic Bisphenol A diglycidyl ether Predicted Metabolism Pathway Homo sapiens Metabolites of Bisphenol A diglycidyl ether are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 12, 2023 at 16:42 Last Updated: December 12, 2023 at 16:42
PW146747 View Pathway	drug action Bisphenol A diglycidyl ether Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:56 Last Updated: October 07, 2023 at 18:56