PathWhiz

PathWhiz ID	Pathway	Meta Data
PW109275 View Pathway	protein Ahr Signal Transduction Pathway Rattus norvegicus The aryl hydrocarbon receptor, known as AHR, is a normally cytosolic transcription factor that can bind to foreign compounds such as flavonoids and indoles from foods, as well as synthetic ligands including polychlorobiphenyls (PCBs) and polychlorinated dibenzo-p-dioxins (PCDD). This includes 2,3,7,8-tetrachlorodibenzodioxin (TCDD), which is the ligand shown in this pathway. AHR interacts with heat shock protein 90 (HSP90AA1), which acts as a chaperone for it. After this association, the ligand, in this case TCDD, can form a covalent bond with the complex in the cell's cytoplasm. This binding causes AHR and the rest of the complex to translocate into the nucleus of the cell. Once in the nucleus, the heat shock protein dissociates, leaving binding sites which the AHR nuclear translocator (ARNT) then binds to. Finally, the AHR/ARNT complex can interact, either directly or indirectly, with the DNA, in this case specifically a dioxin response element. With other ligands, the complex will bind to the equivalent DNA that corresponds to the genes that allow metabolism of the ligand. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 31, 2018 at 12:48 Last Updated: August 31, 2018 at 12:48
PW123577 View Pathway	signaling aha Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: August 16, 2019 at 01:17 Last Updated: August 16, 2019 at 01:17
PW122139 View Pathway	signaling Agrin in Postsynaptic Differentiation Homo sapiens Agrin and acetylcholine act in parallel to shape the postsynaptic apparatus, and skeletal neuromuscular junction development depends critically on the interactions between these factors. In addition to its role in clustering acetylcholine, which has been demonstrated in vitro, agrin also acts to antagonize the effect of acetylcholine receptors. The antideclustering effects of agrin are physiologically crucial, agrin's antideclustering effects in vitro require its z-exon which has been shown to be required for postsynaptic differentiation in vivo. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Noah Created On: September 12, 2018 at 09:27 Last Updated: September 12, 2018 at 09:27
PW128330 View Pathway	drug action Agomelatine Serotonin Antagonist Action Pathway Homo sapiens Agomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors and promotes dopamine and norepinephrine release. Agomelatine is indicated to treat major depressive episodes in adults. It is an atypical antidepressant. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 21, 2023 at 16:01 Last Updated: August 21, 2023 at 16:01
PW176372 View Pathway	metabolic Agomelatine Predicted Metabolism Pathway Homo sapiens Metabolites of Agomelatine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 16:25 Last Updated: December 07, 2023 at 16:25
PW145720 View Pathway	drug action Agomelatine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:28 Last Updated: October 07, 2023 at 16:28
PW012844 View Pathway	metabolic Agnieszka Bielska 1471277183 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: August 15, 2016 at 10:06 Last Updated: August 15, 2016 at 10:06
PW002692 View Pathway	signaling Agnieszka Bielska Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: June 16, 2016 at 06:19 Last Updated: June 16, 2016 at 06:19
PW145889 View Pathway	drug action Afatinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:54 Last Updated: October 07, 2023 at 16:54
PW128495 View Pathway	drug action Afatinib Action Pathway Homo sapiens Afatinib is a tyrosine kinase inhibitor used as an antineoplastic agent for the treatment of advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy. Afatinib binds the phosphorylation domain of the epidermal growth factor receptor. This inhibits the activation of this receptor, thus the cascading signaling pathways, through RAS, can't happen. As a result, this drug provokes the inhibition of cell (cancer) proliferation. Also, Afatinib inhibits the receptor tyrosine-protein kinase erbB-2 and erbB-4. Those receptors usually send a signal to the cell to survive (through the transcription of many proteins and with the help of P13K, AKT, and mTOR). The inhibition of those receptors results in the inhibition of the survival of the cell (death/apoptosis). This drug is administered as an oral tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 31, 2023 at 15:48 Last Updated: August 31, 2023 at 15:48