Pathways

Glycolysis is a metabolic pathway consisting of ten reactions that convert glucose to pyruvate, releasing energy to form ATP and NADH. It occurs in two phases: the chemical priming phase and the energy-yielding phase. In the priming phase, D-glucose, which can be imported or derived from galactose metabolism, is phosphorylated to glucose-6-phosphate by a hexokinase-like enzyme, using ATP. This is then converted to fructose-6-phosphate, which is further phosphorylated to fructose-1,6-bisphosphate by 6-phosphofructokinase, also using ATP. Aldolase then splits fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate, which can interconvert via triosephosphate isomerase. In the energy-yielding phase, glyceraldehyde-3-phosphate is converted to 1,3-bisphosphoglycerate by glyceraldehyde-3-phosphate dehydrogenase, producing NADH in the process. ATP is generated when 1,3-bisphosphoglycerate is converted to 3-phosphoglycerate. Further steps involve the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase, followed by conversion to phosphoenolpyruvate by enolase. Finally, pyruvate kinase converts phosphoenolpyruvate to pyruvate, producing ATP in the process. Pyruvate then participates in further metabolic pathways, including pyruvate metabolism, tyrosine metabolism, and the synthesis of pantothenate and CoA.

Glycolysis is a metabolic pathway consisting of ten reactions that convert glucose to pyruvate, releasing energy to form ATP and NADH. It occurs in two phases: the chemical priming phase and the energy-yielding phase. In the priming phase, D-glucose, which can be imported or derived from galactose metabolism, is phosphorylated to glucose-6-phosphate by a hexokinase-like enzyme, using ATP. This is then converted to fructose-6-phosphate, which is further phosphorylated to fructose-1,6-bisphosphate by 6-phosphofructokinase, also using ATP. Aldolase then splits fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate, which can interconvert via triosephosphate isomerase. In the energy-yielding phase, glyceraldehyde-3-phosphate is converted to 1,3-bisphosphoglycerate by glyceraldehyde-3-phosphate dehydrogenase, producing NADH in the process. ATP is generated when 1,3-bisphosphoglycerate is converted to 3-phosphoglycerate. Further steps involve the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase, followed by conversion to phosphoenolpyruvate by enolase. Finally, pyruvate kinase converts phosphoenolpyruvate to pyruvate, producing ATP in the process. Pyruvate then participates in further metabolic pathways, including pyruvate metabolism, tyrosine metabolism, and the synthesis of pantothenate and CoA.

Glycolysis is a metabolic pathway consisting of ten reactions that convert glucose to pyruvate, releasing energy to form ATP and NADH. It occurs in two phases: the chemical priming phase and the energy-yielding phase. In the priming phase, D-glucose, which can be imported or derived from galactose metabolism, is phosphorylated to glucose-6-phosphate by a hexokinase-like enzyme, using ATP. This is then converted to fructose-6-phosphate, which is further phosphorylated to fructose-1,6-bisphosphate by 6-phosphofructokinase, also using ATP. Aldolase then splits fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate, which can interconvert via triosephosphate isomerase. In the energy-yielding phase, glyceraldehyde-3-phosphate is converted to 1,3-bisphosphoglycerate by glyceraldehyde-3-phosphate dehydrogenase, producing NADH in the process. ATP is generated when 1,3-bisphosphoglycerate is converted to 3-phosphoglycerate. Further steps involve the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase, followed by conversion to phosphoenolpyruvate by enolase. Finally, pyruvate kinase converts phosphoenolpyruvate to pyruvate, producing ATP in the process. Pyruvate then participates in further metabolic pathways, including pyruvate metabolism, tyrosine metabolism, and the synthesis of pantothenate and CoA.

Glycolysis is a metabolic pathway consisting of ten reactions that convert glucose to pyruvate, releasing energy to form ATP and NADH. It occurs in two phases: the chemical priming phase and the energy-yielding phase. In the priming phase, D-glucose, which can be imported or derived from galactose metabolism, is phosphorylated to glucose-6-phosphate by a hexokinase-like enzyme, using ATP. This is then converted to fructose-6-phosphate, which is further phosphorylated to fructose-1,6-bisphosphate by 6-phosphofructokinase, also using ATP. Aldolase then splits fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate, which can interconvert via triosephosphate isomerase. In the energy-yielding phase, glyceraldehyde-3-phosphate is converted to 1,3-bisphosphoglycerate by glyceraldehyde-3-phosphate dehydrogenase, producing NADH in the process. ATP is generated when 1,3-bisphosphoglycerate is converted to 3-phosphoglycerate. Further steps involve the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase, followed by conversion to phosphoenolpyruvate by enolase. Finally, pyruvate kinase converts phosphoenolpyruvate to pyruvate, producing ATP in the process. Pyruvate then participates in further metabolic pathways, including pyruvate metabolism, tyrosine metabolism, and the synthesis of pantothenate and CoA.

Glycolysis is a metabolic pathway with sequence of ten reactions involving ten intermediate compounds that converts glucose to pyruvate. Glycolysis release free energy for forming high energy compound such as ATP and NADH. Glycolysis is consisted of two phases, which one of them is chemical priming phase and second phase is energy-yielding phase. As the starting compound of chemical priming phase, D-glucose can be obtained from galactose metabolism or imported by monosaccharide-sensing protein 1 from outside of cell. D-Glucose is catalyzed by probable hexokinase-like 2 protein to form glucose 6-phosphate which is powered by ATP. Glucose 6-phosphate transformed to fructose 6-phosphate by glucose-6-phosphate isomerase, which the later compound will be converted to fructose 1,6-bisphosphate, which is the last reaction of chemical priming phase by 6-phosphofructokinase with cofactor magnesium, and it is also powered by ATP. Before entering the second phase, aldolase catalyzing the hydrolysis of F1,6BP into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Dihydroxyacetone phosphate and glyceraldehyde 3-phosphate can convert to each other bidirectionally by facilitation of triosephosphate isomerase. The second phase of glycolysis is yielding-energy phase that produce ATP and NADH. At the first step, D-glyceraldehyde 3-phosphate is catalyzed to glyceric acid 1,3-biphosphate by glyceraldehyde-3-phosphate dehydrogenase with NAD, which also generate NADH. ATP is generated through the reaction that convert glyceric acid 1,3-biphosphate to 3-phosphoglyceric acid. Phosphoglycerate mutase 2 catalyze 3-phosphoglyceric acid to 2-Phospho-D-glyceric acid, and alpha-enolase with cofactor magnesium catalyzes 2-Phospho-D-glyceric acid to phosphoenolpyruvic acid. Eventually, plastidial pyruvate kinase 4 converts phosphoenolpyruvic acid to pyruvate with cofactor magnesium and potassium and ADP. Pyruvate will undergo pyruvate metabolism, tyrosine metabolism and pantothenate and CoA biosynthesis.

Glycolysis is a metabolic pathway consisting of ten reactions that convert glucose to pyruvate, releasing energy to form ATP and NADH. It occurs in two phases: the chemical priming phase and the energy-yielding phase. In the priming phase, D-glucose, which can be imported or derived from galactose metabolism, is phosphorylated to glucose-6-phosphate by a hexokinase-like enzyme, using ATP. This is then converted to fructose-6-phosphate, which is further phosphorylated to fructose-1,6-bisphosphate by 6-phosphofructokinase, also using ATP. Aldolase then splits fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate, which can interconvert via triosephosphate isomerase. In the energy-yielding phase, glyceraldehyde-3-phosphate is converted to 1,3-bisphosphoglycerate by glyceraldehyde-3-phosphate dehydrogenase, producing NADH in the process. ATP is generated when 1,3-bisphosphoglycerate is converted to 3-phosphoglycerate. Further steps involve the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase, followed by conversion to phosphoenolpyruvate by enolase. Finally, pyruvate kinase converts phosphoenolpyruvate to pyruvate, producing ATP in the process. Pyruvate then participates in further metabolic pathways, including pyruvate metabolism, tyrosine metabolism, and the synthesis of pantothenate and CoA.

Glycolysis is a metabolic pathway consisting of ten reactions that convert glucose to pyruvate, releasing energy to form ATP and NADH. It occurs in two phases: the chemical priming phase and the energy-yielding phase. In the priming phase, D-glucose, which can be imported or derived from galactose metabolism, is phosphorylated to glucose-6-phosphate by a hexokinase-like enzyme, using ATP. This is then converted to fructose-6-phosphate, which is further phosphorylated to fructose-1,6-bisphosphate by 6-phosphofructokinase, also using ATP. Aldolase then splits fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate, which can interconvert via triosephosphate isomerase. In the energy-yielding phase, glyceraldehyde-3-phosphate is converted to 1,3-bisphosphoglycerate by glyceraldehyde-3-phosphate dehydrogenase, producing NADH in the process. ATP is generated when 1,3-bisphosphoglycerate is converted to 3-phosphoglycerate. Further steps involve the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase, followed by conversion to phosphoenolpyruvate by enolase. Finally, pyruvate kinase converts phosphoenolpyruvate to pyruvate, producing ATP in the process. Pyruvate then participates in further metabolic pathways, including pyruvate metabolism, tyrosine metabolism, and the synthesis of pantothenate and CoA.

Glycolysis is a metabolic pathway consisting of ten reactions that convert glucose to pyruvate, releasing energy to form ATP and NADH. It occurs in two phases: the chemical priming phase and the energy-yielding phase. In the priming phase, D-glucose, which can be imported or derived from galactose metabolism, is phosphorylated to glucose-6-phosphate by a hexokinase-like enzyme, using ATP. This is then converted to fructose-6-phosphate, which is further phosphorylated to fructose-1,6-bisphosphate by 6-phosphofructokinase, also using ATP. Aldolase then splits fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate, which can interconvert via triosephosphate isomerase. In the energy-yielding phase, glyceraldehyde-3-phosphate is converted to 1,3-bisphosphoglycerate by glyceraldehyde-3-phosphate dehydrogenase, producing NADH in the process. ATP is generated when 1,3-bisphosphoglycerate is converted to 3-phosphoglycerate. Further steps involve the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase, followed by conversion to phosphoenolpyruvate by enolase. Finally, pyruvate kinase converts phosphoenolpyruvate to pyruvate, producing ATP in the process. Pyruvate then participates in further metabolic pathways, including pyruvate metabolism, tyrosine metabolism, and the synthesis of pantothenate and CoA.

Glycolysis is a metabolic pathway consisting of ten reactions that convert glucose to pyruvate, releasing energy to form ATP and NADH. It occurs in two phases: the chemical priming phase and the energy-yielding phase. In the priming phase, D-glucose, which can be imported or derived from galactose metabolism, is phosphorylated to glucose-6-phosphate by a hexokinase-like enzyme, using ATP. This is then converted to fructose-6-phosphate, which is further phosphorylated to fructose-1,6-bisphosphate by 6-phosphofructokinase, also using ATP. Aldolase then splits fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate, which can interconvert via triosephosphate isomerase. In the energy-yielding phase, glyceraldehyde-3-phosphate is converted to 1,3-bisphosphoglycerate by glyceraldehyde-3-phosphate dehydrogenase, producing NADH in the process. ATP is generated when 1,3-bisphosphoglycerate is converted to 3-phosphoglycerate. Further steps involve the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase, followed by conversion to phosphoenolpyruvate by enolase. Finally, pyruvate kinase converts phosphoenolpyruvate to pyruvate, producing ATP in the process. Pyruvate then participates in further metabolic pathways, including pyruvate metabolism, tyrosine metabolism, and the synthesis of pantothenate and CoA.

Glycolysis is a metabolic pathway consisting of ten reactions that convert glucose to pyruvate, releasing energy to form ATP and NADH. It occurs in two phases: the chemical priming phase and the energy-yielding phase. In the priming phase, D-glucose, which can be imported or derived from galactose metabolism, is phosphorylated to glucose-6-phosphate by a hexokinase-like enzyme, using ATP. This is then converted to fructose-6-phosphate, which is further phosphorylated to fructose-1,6-bisphosphate by 6-phosphofructokinase, also using ATP. Aldolase then splits fructose-1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde-3-phosphate, which can interconvert via triosephosphate isomerase. In the energy-yielding phase, glyceraldehyde-3-phosphate is converted to 1,3-bisphosphoglycerate by glyceraldehyde-3-phosphate dehydrogenase, producing NADH in the process. ATP is generated when 1,3-bisphosphoglycerate is converted to 3-phosphoglycerate. Further steps involve the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase, followed by conversion to phosphoenolpyruvate by enolase. Finally, pyruvate kinase converts phosphoenolpyruvate to pyruvate, producing ATP in the process. Pyruvate then participates in further metabolic pathways, including pyruvate metabolism, tyrosine metabolism, and the synthesis of pantothenate and CoA.