PathWhiz

PathWhiz ID	Pathway	Meta Data
PW121922 View Pathway	disease 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency Rattus norvegicus 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency (SSADH; Gamma-hydroxybutyric acidemia) inhibits the formation of succinate from GABA. This deficiency results in urinary excretion of 4-hydroxybutyric acid. In vivo proton MR also indicates elevated GABA levels as compared with an age-matched control. Symptoms include ataxia, chorea or athetosis, motor retardation, seizures, macrocephaly and delayed or abnormal speech development. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:51 Last Updated: September 10, 2018 at 15:51
PW147022 View Pathway	metabolic 4-Hydroxybutyric acid Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:40 Last Updated: October 10, 2023 at 13:40
PW251361 View Pathway	metabolic 4-Chlorobiphenyl degradation Pseudoxanthomonas spadix 4-chlorobiphenyl, a PCB and environmental pollutant, is degraded by bacteria e.g., Pseudoxanthomonas spadix a source of carbon and energy. 4-Chlorobiphenyl degradation in Pseudoxanthomonas spadix begins with the oxidation of 4-chlorobiphenyl by biphenyl 2,3-dioxygenase small subunit (BphA2) to form an intermediate compound, cis-2,3-Dihydro-2,3-dihydroxy-4'-chlorobiphenyl. This intermediate is then dehydrogenated to 2,3-Dihydroxy-4'-chlorobiphenyl, by 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase. Subsequently, the compound is converted by 2,3-dihydroxybiphenyl-1,2-dioxygenase to form 2-Hydroxy-6-oxo-6-(4'-chlorophenyl)-hexa-2,4-dienoate, that is further degraded to produce compounds such as pyruvate and acetyl-COA which are essential for glycolysis and citrate cycle. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: May 22, 2024 at 13:58 Last Updated: May 22, 2024 at 13:58
PW146983 View Pathway	metabolic 4-Aminohippuric acid Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:35 Last Updated: October 10, 2023 at 13:35
PW365983 View Pathway	metabolic 4-Aminobutanoate Degradation I Alistipes shahii WAL 8301 Putrescine is an organic chemical produced when amino acids are broken down in organsisms, both living and dead. It can be used as a carbon and nitrogen source in E. coli, and is broken down into gamma-aminobutyric acid (GABA). In this pathway, GABA from putrescine degradation reacts with oxoglutaric acid in a reversible reaction catalyzed by 4-aminobutyrate aminotransferase. This reaction forms succinic acid semialdehyde, as well as L-glutamic acid as a byproduct. Succinic acid semialdehyde is then converted to succinic acid in a reaction catalyzed by succinate-semialdehyde dehydrogenase, using NAD as a cofactor. Succinic acid can then be used by the bacteria in the TCA cycle. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: November 20, 2024 at 08:17 Last Updated: November 20, 2024 at 08:17
PW366777 View Pathway	metabolic 4-Aminobutanoate Degradation I Vibrio fluvialis PG41 Putrescine is an organic chemical produced when amino acids are broken down in organsisms, both living and dead. It can be used as a carbon and nitrogen source in E. coli, and is broken down into gamma-aminobutyric acid (GABA). In this pathway, GABA from putrescine degradation reacts with oxoglutaric acid in a reversible reaction catalyzed by 4-aminobutyrate aminotransferase. This reaction forms succinic acid semialdehyde, as well as L-glutamic acid as a byproduct. Succinic acid semialdehyde is then converted to succinic acid in a reaction catalyzed by succinate-semialdehyde dehydrogenase, using NAD as a cofactor. Succinic acid can then be used by the bacteria in the TCA cycle. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: November 20, 2024 at 16:26 Last Updated: November 20, 2024 at 16:26
PW366498 View Pathway	metabolic 4-Aminobutanoate Degradation I Bacteroides oleiciplenus YIT 12058 Putrescine is an organic chemical produced when amino acids are broken down in organsisms, both living and dead. It can be used as a carbon and nitrogen source in E. coli, and is broken down into gamma-aminobutyric acid (GABA). In this pathway, GABA from putrescine degradation reacts with oxoglutaric acid in a reversible reaction catalyzed by 4-aminobutyrate aminotransferase. This reaction forms succinic acid semialdehyde, as well as L-glutamic acid as a byproduct. Succinic acid semialdehyde is then converted to succinic acid in a reaction catalyzed by succinate-semialdehyde dehydrogenase, using NAD as a cofactor. Succinic acid can then be used by the bacteria in the TCA cycle. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: November 20, 2024 at 12:38 Last Updated: November 20, 2024 at 12:38
PW366645 View Pathway	metabolic 4-Aminobutanoate Degradation I Burkholderia cepacia GG4 Putrescine is an organic chemical produced when amino acids are broken down in organsisms, both living and dead. It can be used as a carbon and nitrogen source in E. coli, and is broken down into gamma-aminobutyric acid (GABA). In this pathway, GABA from putrescine degradation reacts with oxoglutaric acid in a reversible reaction catalyzed by 4-aminobutyrate aminotransferase. This reaction forms succinic acid semialdehyde, as well as L-glutamic acid as a byproduct. Succinic acid semialdehyde is then converted to succinic acid in a reaction catalyzed by succinate-semialdehyde dehydrogenase, using NAD as a cofactor. Succinic acid can then be used by the bacteria in the TCA cycle. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: November 20, 2024 at 14:31 Last Updated: November 20, 2024 at 14:31
PW366664 View Pathway	metabolic 4-Aminobutanoate Degradation I Neisseria macacae ATCC 33926 Putrescine is an organic chemical produced when amino acids are broken down in organsisms, both living and dead. It can be used as a carbon and nitrogen source in E. coli, and is broken down into gamma-aminobutyric acid (GABA). In this pathway, GABA from putrescine degradation reacts with oxoglutaric acid in a reversible reaction catalyzed by 4-aminobutyrate aminotransferase. This reaction forms succinic acid semialdehyde, as well as L-glutamic acid as a byproduct. Succinic acid semialdehyde is then converted to succinic acid in a reaction catalyzed by succinate-semialdehyde dehydrogenase, using NAD as a cofactor. Succinic acid can then be used by the bacteria in the TCA cycle. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: November 20, 2024 at 14:48 Last Updated: November 20, 2024 at 14:48
PW366688 View Pathway	metabolic 4-Aminobutanoate Degradation I Campylobacter upsaliensis JV21 Putrescine is an organic chemical produced when amino acids are broken down in organsisms, both living and dead. It can be used as a carbon and nitrogen source in E. coli, and is broken down into gamma-aminobutyric acid (GABA). In this pathway, GABA from putrescine degradation reacts with oxoglutaric acid in a reversible reaction catalyzed by 4-aminobutyrate aminotransferase. This reaction forms succinic acid semialdehyde, as well as L-glutamic acid as a byproduct. Succinic acid semialdehyde is then converted to succinic acid in a reaction catalyzed by succinate-semialdehyde dehydrogenase, using NAD as a cofactor. Succinic acid can then be used by the bacteria in the TCA cycle. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: November 20, 2024 at 15:09 Last Updated: November 20, 2024 at 15:09