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PW121818

Pw121818 View Pathway
disease

Tyrosine Hydroxylase Deficiency

Mus musculus
Tyrosine Hydroxylase (TH) Deficiency is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of catecholamines pathways. The disorder is caused by defects in the Tyrosine hydroxylase (TH) gene which encodes for the enzyme tyrosine hydroxylase. This enzyme is part of the production of catecholamines such as dopamine, norepinephrine and epinephrine are all essential for normal nervous system function. Dopamine transmits signals to help the brain control physical movement and emotional behavior. Norepinephrine and epinephrine are involved in the autonomic nervous system. Mutations in the TH gene result in reduced activity of the tyrosine hydroxylase enzyme. As a result, the body produces less dopamine, norepinephrine and epinephrine. Symptoms of the disorder include abnormal movements, autonomic dysfunction, and other neurological problems. Treatments can include the administration of levodopa; however patient responses can vary greatly. The frequency of Tyrosine Hydroxylase Deficiency is unknown.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ana Marcu

Created On: September 10, 2018 at 15:49

Last Updated: September 10, 2018 at 15:49

PW144277

Pw144277 View Pathway
drug action

Tyrosine Drug Metabolism Action Pathway

Homo sapiens
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ray Kruger

Created On: October 07, 2023 at 13:05

Last Updated: October 07, 2023 at 13:05

PW300314

Pw300314 View Pathway
metabolic

Tyrosine Biosynthesis

Actinobacillus pleuropneumoniae serovar 7 str. AP76
Tyrosine is one of the amino acid used in protein synthesis. The tyrosine biosynthesis pathways is connected with the chorismate biosynthesis pathway. Chorismate biosynthesis produce the chorismate, which can further be converted to prephenate by T-protein. Combined with cofactor, NAD, prephenate has been further converted to 4-Hydroxyphenylpyruvic acid by T-protein with generated NADH and carbon dioxide. Tyrosine aminotransferase catalyzes 4-Hydroxyphenylpyruvic acid to tyrosine, and also converts glutamic acid to oxoglutaric acid. Tyrosine will be further catalyzed into various molecules such as 2-iminoacetate, p-Cresol, 5'Deoxyadenosine and L-Methionine; or it will be exported from cell via the lysine exporter.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: September 25, 2024 at 16:04

Last Updated: September 25, 2024 at 16:04

PW300326

Pw300326 View Pathway
metabolic

Tyrosine Biosynthesis

Buchnera aphidicola str. Tuc7 (Acyrthosiphon pisum)
Tyrosine is one of the amino acid used in protein synthesis. The tyrosine biosynthesis pathways is connected with the chorismate biosynthesis pathway. Chorismate biosynthesis produce the chorismate, which can further be converted to prephenate by T-protein. Combined with cofactor, NAD, prephenate has been further converted to 4-Hydroxyphenylpyruvic acid by T-protein with generated NADH and carbon dioxide. Tyrosine aminotransferase catalyzes 4-Hydroxyphenylpyruvic acid to tyrosine, and also converts glutamic acid to oxoglutaric acid. Tyrosine will be further catalyzed into various molecules such as 2-iminoacetate, p-Cresol, 5'Deoxyadenosine and L-Methionine; or it will be exported from cell via the lysine exporter.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: September 25, 2024 at 16:07

Last Updated: September 25, 2024 at 16:07

PW300321

Pw300321 View Pathway
metabolic

Tyrosine Biosynthesis

Buchnera aphidicola str. APS (Acyrthosiphon pisum)
Tyrosine is one of the amino acid used in protein synthesis. The tyrosine biosynthesis pathways is connected with the chorismate biosynthesis pathway. Chorismate biosynthesis produce the chorismate, which can further be converted to prephenate by T-protein. Combined with cofactor, NAD, prephenate has been further converted to 4-Hydroxyphenylpyruvic acid by T-protein with generated NADH and carbon dioxide. Tyrosine aminotransferase catalyzes 4-Hydroxyphenylpyruvic acid to tyrosine, and also converts glutamic acid to oxoglutaric acid. Tyrosine will be further catalyzed into various molecules such as 2-iminoacetate, p-Cresol, 5'Deoxyadenosine and L-Methionine; or it will be exported from cell via the lysine exporter.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: September 25, 2024 at 16:05

Last Updated: September 25, 2024 at 16:05

PW300319

Pw300319 View Pathway
metabolic

Tyrosine Biosynthesis

Bartonella quintana str. Toulouse
Tyrosine is one of the amino acid used in protein synthesis. The tyrosine biosynthesis pathways is connected with the chorismate biosynthesis pathway. Chorismate biosynthesis produce the chorismate, which can further be converted to prephenate by T-protein. Combined with cofactor, NAD, prephenate has been further converted to 4-Hydroxyphenylpyruvic acid by T-protein with generated NADH and carbon dioxide. Tyrosine aminotransferase catalyzes 4-Hydroxyphenylpyruvic acid to tyrosine, and also converts glutamic acid to oxoglutaric acid. Tyrosine will be further catalyzed into various molecules such as 2-iminoacetate, p-Cresol, 5'Deoxyadenosine and L-Methionine; or it will be exported from cell via the lysine exporter.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: September 25, 2024 at 16:05

Last Updated: September 25, 2024 at 16:05

PW300307

Pw300307 View Pathway
metabolic

Tyrosine Biosynthesis

Acinetobacter baumannii SDF
Tyrosine is one of the amino acid used in protein synthesis. The tyrosine biosynthesis pathways is connected with the chorismate biosynthesis pathway. Chorismate biosynthesis produce the chorismate, which can further be converted to prephenate by T-protein. Combined with cofactor, NAD, prephenate has been further converted to 4-Hydroxyphenylpyruvic acid by T-protein with generated NADH and carbon dioxide. Tyrosine aminotransferase catalyzes 4-Hydroxyphenylpyruvic acid to tyrosine, and also converts glutamic acid to oxoglutaric acid. Tyrosine will be further catalyzed into various molecules such as 2-iminoacetate, p-Cresol, 5'Deoxyadenosine and L-Methionine; or it will be exported from cell via the lysine exporter.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: September 25, 2024 at 16:02

Last Updated: September 25, 2024 at 16:02

PW300294

Pw300294 View Pathway
metabolic

Tyrosine Biosynthesis

Prevotella intermedia 17
Tyrosine is one of the amino acid used in protein synthesis. The tyrosine biosynthesis pathways is connected with the chorismate biosynthesis pathway. Chorismate biosynthesis produce the chorismate, which can further be converted to prephenate by T-protein. Combined with cofactor, NAD, prephenate has been further converted to 4-Hydroxyphenylpyruvic acid by T-protein with generated NADH and carbon dioxide. Tyrosine aminotransferase catalyzes 4-Hydroxyphenylpyruvic acid to tyrosine, and also converts glutamic acid to oxoglutaric acid. Tyrosine will be further catalyzed into various molecules such as 2-iminoacetate, p-Cresol, 5'Deoxyadenosine and L-Methionine; or it will be exported from cell via the lysine exporter.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: September 25, 2024 at 15:59

Last Updated: September 25, 2024 at 15:59

PW300275

Pw300275 View Pathway
metabolic

Tyrosine Biosynthesis

Bradyrhizobium elkanii USDA 76
Tyrosine is one of the amino acid used in protein synthesis. The tyrosine biosynthesis pathways is connected with the chorismate biosynthesis pathway. Chorismate biosynthesis produce the chorismate, which can further be converted to prephenate by T-protein. Combined with cofactor, NAD, prephenate has been further converted to 4-Hydroxyphenylpyruvic acid by T-protein with generated NADH and carbon dioxide. Tyrosine aminotransferase catalyzes 4-Hydroxyphenylpyruvic acid to tyrosine, and also converts glutamic acid to oxoglutaric acid. Tyrosine will be further catalyzed into various molecules such as 2-iminoacetate, p-Cresol, 5'Deoxyadenosine and L-Methionine; or it will be exported from cell via the lysine exporter.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: September 25, 2024 at 15:54

Last Updated: September 25, 2024 at 15:54

PW300282

Pw300282 View Pathway
metabolic

Tyrosine Biosynthesis

Eubacterium eligens ATCC 27750
Tyrosine is one of the amino acid used in protein synthesis. The tyrosine biosynthesis pathways is connected with the chorismate biosynthesis pathway. Chorismate biosynthesis produce the chorismate, which can further be converted to prephenate by T-protein. Combined with cofactor, NAD, prephenate has been further converted to 4-Hydroxyphenylpyruvic acid by T-protein with generated NADH and carbon dioxide. Tyrosine aminotransferase catalyzes 4-Hydroxyphenylpyruvic acid to tyrosine, and also converts glutamic acid to oxoglutaric acid. Tyrosine will be further catalyzed into various molecules such as 2-iminoacetate, p-Cresol, 5'Deoxyadenosine and L-Methionine; or it will be exported from cell via the lysine exporter.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: September 25, 2024 at 15:55

Last Updated: September 25, 2024 at 15:55