PathWhiz

PathWhiz ID	Pathway	Meta Data
PW144375 View Pathway	drug action Ziprasidone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:30 Last Updated: October 07, 2023 at 13:30
PW128071 View Pathway	drug action Ziprasidone Dopamine Antagonist Action Pathway Homo sapiens Ziprasidone is an atypical antipsychotic used to treat schizophrenia, bipolar mania, and acute agitation in schizophrenic patients. It also indicated improvement on the manic syndrome subscale that measures symptoms of mania such as mood, insomnia, excessive energy and activity, and overall behavior and ideation. Ziprasidone is also used as off-labeled for monotherapy in acute hypomania, monotherapy as maintenance treatment for adult patients with bipolar I disorder, hyperactivity treatment, and for the treatment of delirium in the ICU. Ziprasidone presents in both oral capsule and intramuscular injection formulations. Ziprasidone is an atypical antipsychotic that has a binding affinity for dopaminergic (DA), serotonergic (5HT), adrenergic (a1), and histaminergic (HA) receptors. Regarding treatment for schizophrenia, antagonism of the dopamine (D2) receptor in the mesolimbic pathway has proven efficacious in diminishing positive symptoms, whereas the antagonism of the 5HT2A receptor in the mesocortical pathway has demonstrated reduction of negative symptoms of psychosis. Its efficacy and mechanism of action for treating bipolar disorder are unknown. The antagonization of both histaminergic and adrenergic (a1) receptors can induce somnolence and orthostatic hypotension. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: July 13, 2023 at 09:43 Last Updated: July 13, 2023 at 09:43
PW146848 View Pathway	drug action Zinc sulfate, unspecified form Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:11 Last Updated: October 07, 2023 at 19:11
PW146089 View Pathway	drug action Zinc sulfate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:23 Last Updated: October 07, 2023 at 17:23
PW146940 View Pathway	drug action Zinc phenolsulfonate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:24 Last Updated: October 07, 2023 at 19:24
PW132211 View Pathway	metabolic Zinc phenolsulfonate Drug Metabolism Homo sapiens Zinc phenolsulfonate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Zinc phenolsulfonate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:09 Last Updated: September 21, 2023 at 20:09
PW146088 View Pathway	drug action Zinc oxide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:23 Last Updated: October 07, 2023 at 17:23
PW146318 View Pathway	drug action Zinc gluconate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:55 Last Updated: October 07, 2023 at 17:55
PW132215 View Pathway	metabolic Zinc gluconate Drug Metabolism Homo sapiens Zinc gluconate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Zinc gluconate passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:11 Last Updated: September 21, 2023 at 20:11
PW145462 View Pathway	drug action Zinc Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:52 Last Updated: October 07, 2023 at 15:52