PathWhiz

PathWhiz ID	Pathway	Meta Data
PW127675 View Pathway	drug action Trolamine salicylate Action Pathway Homo sapiens Trolamine salicylate is a nonsteroidal anti-inflammatory agent (NSAID) used for the temporary relief of some minor aches and pains of the muscles and joints associated with backache, lumbago, strains, bruises, sprains, and arthritic or rheumatic pain, pain of tendons and ligaments. This drug is used as a topical analgesic. It targets the prostaglandin G/H synthase-1 (COX-1) and prostaglandin G/H synthase-2 (COX-2) in the cyclooxygenase pathway. The cyclooxygenase pathway begins in the cytosol with phospholipids being converted into arachidonic acid by the action of phospholipase A2. The rest of the pathway occurs on the endoplasmic reticulum membrane, where prostaglandin G/H synthase 1 & 2 convert arachidonic acid into prostaglandin H2. Prostaglandin H2 can either be converted into thromboxane A2 via thromboxane A synthase, prostacyclin/prostaglandin I2 via prostacyclin synthase, or prostaglandin E2 via prostaglandin E synthase. COX-2 is an inducible enzyme, and during inflammation, it is responsible for prostaglandin synthesis. It leads to the formation of prostaglandin E2 which is responsible for contributing to the inflammatory response by activating immune cells and for increasing pain sensation by acting on pain fibers. Trolamine salicylate inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2). The low concentration of prostaglandin E2 attenuates the effect it has on stimulating immune cells and pain fibers, consequently reducing inflammation and pain. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: May 19, 2023 at 10:35 Last Updated: May 19, 2023 at 10:35
PW146119 View Pathway	drug action Trolamine polypeptide oleate condensate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:27 Last Updated: October 07, 2023 at 17:27
PW147059 View Pathway	metabolic Trolamine Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:46 Last Updated: October 10, 2023 at 13:46
PW176536 View Pathway	metabolic Troglitazone Predicted Metabolism Pathway Homo sapiens Metabolites of Troglitazone are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 13, 2023 at 14:47 Last Updated: December 13, 2023 at 14:47
PW144328 View Pathway	drug action Troglitazone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:24 Last Updated: October 07, 2023 at 13:24
PW123859 View Pathway	protein tRNA Charging: Serine Homo sapiens An aminoacyl-tRNA synthetase (aaRS or ARS), also called tRNA-ligase, is an enzyme that attaches the appropriate amino acid onto its tRNA. It does so by catalyzing the esterification of a specific cognate amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA. The 20 different types of aa-tRNA are made by the 20 different aminoacyl-tRNA synthetases, one for each amino acid of the genetic code. This process is sometimes called "charging" or "loading" the tRNA with the amino acid. Once the tRNA is charged, a ribosome can transfer the amino acid from the tRNA onto a growing peptide, according to the genetic code. Aminoacyl-tRNA, therefore, plays an important role in translation, the expression of genes to create proteins. Translation is carried out by ribosomes in the cytoplasm or endoplasmic reticulum after the process of transcription of DNA to RNA in the cell's nucleus (Wikipedia). BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: April 15, 2020 at 12:18 Last Updated: April 15, 2020 at 12:18
PW122591 View Pathway	metabolic tRNA Charging 2 Pseudomonas aeruginosa This pathway is a compilation of Escherichia coli tRNA charging reactions involving biosynthesized amino acids. The aminoacyl-tRNA synthetase is an enzyme that attaches the appropriate amino acid onto its tRNA by catalyzing the esterification of a specific cognate amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA, which plays an important role in RNA translation. 20 different Aminoacyl-tRNA synthetases can make 20 different types of aa-tRNA for each amino acid according to the genetic code. This process is called "charging" or "loading" the tRNA with amino acid. Ribosome can transfer the amino acid from tRNA to a growing peptide after the tRNA is charged. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 18:19 Last Updated: August 12, 2019 at 18:19
PW000803 View Pathway	metabolic tRNA Charging 2 Escherichia coli This pathway is a compilation of Escherichia coli tRNA charging reactions involving biosynthesized amino acids. The aminoacyl-tRNA synthetase is an enzyme that attaches the appropriate amino acid onto its tRNA by catalyzing the esterification of a specific cognate amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA, which plays an important role in RNA translation. 20 different Aminoacyl-tRNA synthetases can make 20 different types of aa-tRNA for each amino acid according to the genetic code. This process is called "charging" or "loading" the tRNA with amino acid. Ribosome can transfer the amino acid from tRNA to a growing peptide after the tRNA is charged. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: March 14, 2015 at 14:45 Last Updated: March 14, 2015 at 14:45
PW122589 View Pathway	metabolic tRNA Charging Pseudomonas aeruginosa This pathway is a compilation of Escherichia coli tRNA charging reactions involving amino acids transported into the cell. The aminoacyl-tRNA synthetase is an enzyme that attaches the appropriate amino acid onto its tRNA by catalyzing the esterification of a specific cognate amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA, which plays an important role in RNA translation. 20 different Aminoacyl-tRNA synthetases can make 20 different types of aa-tRNA for each amino acid according to the genetic code. This process is called "charging" or "loading" the tRNA with amino acid. Ribosome can transfer the amino acid from tRNA to a growing peptide after the tRNA is charged. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 18:18 Last Updated: August 12, 2019 at 18:18
PW000799 View Pathway	metabolic tRNA Charging Escherichia coli This pathway is a compilation of Escherichia coli tRNA charging reactions involving amino acids transported into the cell. The aminoacyl-tRNA synthetase is an enzyme that attaches the appropriate amino acid onto its tRNA by catalyzing the esterification of a specific cognate amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA, which plays an important role in RNA translation. 20 different Aminoacyl-tRNA synthetases can make 20 different types of aa-tRNA for each amino acid according to the genetic code. This process is called "charging" or "loading" the tRNA with amino acid. Ribosome can transfer the amino acid from tRNA to a growing peptide after the tRNA is charged. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: March 09, 2015 at 23:49 Last Updated: March 09, 2015 at 23:49