PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128212 View Pathway	drug action Triflupromazine - Dopamine Antagonist Action Pathway Homo sapiens Triflupromazine is a member of a class of drugs called phenothiazines, which are dopamine D1/D2 receptor antagonists. Triflupromazine is used particularly to control violent behavior during acute episodes of psychotic disorders. It can also be used to control severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Triflupromazine acts on the central nervous system. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre. Triflupromazine blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract. Triflupromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT2B). Dopamine hypothesis states that dopamine abnormalities in the mesolimbic and prefrontal brain regions exist in schizophrenia. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 03, 2023 at 11:37 Last Updated: August 03, 2023 at 11:37
PW144937 View Pathway	drug action Trifluoperazine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:44 Last Updated: October 07, 2023 at 14:44
PW128161 View Pathway	drug action Trifluoperazine Dopamine Antagonist Action Pathway Homo sapiens Trifluoperazine is a trifluoro-methyl phenothiazine derivative. Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. It is indicated for the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: July 26, 2023 at 14:40 Last Updated: July 26, 2023 at 14:40
PW176155 View Pathway	metabolic Trifarotene Predicted Metabolism Pathway new Homo sapiens Metabolites of Trifarotene are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 14:22 Last Updated: November 29, 2023 at 14:22
PW146558 View Pathway	drug action Trifarotene Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:30 Last Updated: October 07, 2023 at 18:30
PW145824 View Pathway	drug action Triethylenetetramine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:45 Last Updated: October 07, 2023 at 16:45
PW145832 View Pathway	drug action Triclosan Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:46 Last Updated: October 07, 2023 at 16:46
PW145768 View Pathway	drug action Triclofos Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:36 Last Updated: October 07, 2023 at 16:36
PW146271 View Pathway	drug action Triclocarban Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:50 Last Updated: October 07, 2023 at 17:50
PW132432 View Pathway	metabolic Triclocarban Drug Metabolism Homo sapiens Triclocarban is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Triclocarban passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:44 Last Updated: September 21, 2023 at 21:44