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Showing 61 - 80 of 9284 proteins

Protein ID	Protein Description	Pathway Class	Pathways
P77488 View in UniProt	1-deoxy-D-xylulose-5-phosphate synthase Gene Name: dxs Involved in 1-deoxy-D-xylulose-5-phosphate synthase activity. Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).	Metabolic	Secondary Metabolites: Isoprenoid Biosynthesis (Nonmevalonate Pathway) Secondary Metabolites: Methylerythritol Phosphate and Polyisoprenoid Biosynthesis Thiazole Biosynthesis I
Q9CU94 View in UniProt	1-phosphatidylinositol 3-phosphate 5-kinase Gene Name: Pikfyve The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole.	Metabolic	Inositol Metabolism Joubert Syndrome Phosphatidylinositol Phosphate Metabolism
P34756 View in UniProt	1-phosphatidylinositol 3-phosphate 5-kinase FAB1 Gene Name: FAB1 The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole. Hyperosmotic shock-induced increase in the levels of PtdIns(3,5)P2 requires the presence of VAC7, VAC14, and/or FIG4.	Metabolic	Inositol Metabolism
Q9W4K9 View in UniProt	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase Gene Name: norpA The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).	Metabolic	Inositol Metabolism
P32383 View in UniProt	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 Gene Name: PLC1 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Required for cell growth, osmoresistance and expression of GPD1.	Metabolic	Inositol Metabolism
Q9U6B9 View in UniProt	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 Gene Name: egl-8 Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion (PubMed:10571228). Plays a role in efficient egg laying and defecation (PubMed:10571227, PubMed:10571228, PubMed:24212673). Involved in axon regeneration after injury (PubMed:23072806). Plays a role in male mating behavior by regulating spicule insertion and sperm transfer (PubMed:15958491). By triggering Ca(2+) transient via IP3-mediated activation of IPR3 receptor itr-1 in ASH sensory neurons, regulates avoidance behavior in response to nose touch (PubMed:19730689). By activating tpa-1 via DAG production, required for the expression of antimicrobial peptide nlp-29 in response to fungal infection (PubMed:19380113). During embryogenesis, may play a role in epidermal morphogenesis together with plc-1 (PubMed:18369461).	Metabolic	Inositol Metabolism Phosphatidylinositol Phosphate Metabolism
P10687 View in UniProt	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Gene Name: Plcb1 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Metabolic	Activation of PKC Through G Protein-Coupled Receptor Cadmium Induces DNA Synthesis and Proliferation in Macrophages G-Protein Signaling Through Tubby Proteins Gi Adrenergic Smooth Muscle Contraction GnRH Signaling Pathway Gq Adrenergic Smooth Muscle Contraction Gq Histaminic Smooth Muscle Contraction Gq Muscarinic Smooth Muscle Contraction Gs Adrenergic Smooth Muscle Relaxation Gs Histaminic Smooth Muscle Relaxation Histamine - H1 Dilation Pathway Histamine H1 Receptor Activation Histamine Immune Response Pathway Histamine Muscle Contraction Pathway Incretins - Insulin release Pathway Joubert Syndrome Lysophosphatidic Acid LPA1 Signalling Lysophosphatidic Acid LPA2 Signalling Lysophosphatidic Acid LPA3 Signalling Lysophosphatidic Acid LPA4 Signalling Lysophosphatidic Acid LPA5 Signalling Muscle/Heart Contraction Muscular Gi Protein Cascade Muscular Gq Protien Cascade Muscular Gs Protein Cascade Neuronal serotonin Gq protein cascade Phosphatidylinositol Phosphate Metabolism Phospholipase C Signaling Pathway Phospholipase C Signaling Pathway Succinate Signalling During Inflammation ( show more show less )
Q9Z2T5 View in UniProt	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Gene Name: Plcb1 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Metabolic	Activation of PKC Through G Protein-Coupled Receptor Cadmium Induces DNA Synthesis and Proliferation in Macrophages G-Protein Signaling Through Tubby Proteins Gi Adrenergic Smooth Muscle Contraction GnRH Signaling Pathway Gq Adrenergic Smooth Muscle Contraction Gq Histaminic Smooth Muscle Contraction Gq Muscarinic Smooth Muscle Contraction Gs Adrenergic Smooth Muscle Relaxation Gs Histaminic Smooth Muscle Relaxation Histamine - H1 Dilation Pathway Histamine H1 Receptor Activation Histamine Immune Response Pathway Histamine Muscle Contraction Pathway Incretins - Insulin release Pathway Joubert Syndrome Lysophosphatidic Acid LPA1 Signalling Lysophosphatidic Acid LPA2 Signalling Lysophosphatidic Acid LPA3 Signalling Lysophosphatidic Acid LPA4 Signalling Lysophosphatidic Acid LPA5 Signalling Muscle/Heart Contraction Muscular Gi Protein Cascade Muscular Gq Protien Cascade Muscular Gs Protein Cascade Neuronal serotonin Gq protein cascade Phosphatidylinositol Phosphate Metabolism Phospholipase C Signaling Pathway Phospholipase C Signaling Pathway Succinate Signalling During Inflammation ( show more show less )
Q9NQ66 View in UniProt HMDBP00222 View in HMDB	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Gene Name: PLCB1 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Metabolic	Amifampridine Action Pathway Aceprometazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Aceprometazine H1-Antihistamine Blood Vessel Constriction Action Pathway Aceprometazine H1-Antihistamine Immune Response Action Pathway Acrivastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Acrivastine H1-Antihistamine Action Acrivastine H1-Antihistamine Blood Vessel Constriction Action Pathway Acrivastine H1-Antihistamine Immune Response Action Pathway Activation of PKC Through G Protein-Coupled Receptor Alcaftadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Alcaftadine H1-Antihistamine Action Alcaftadine H1-Antihistamine Blood Vessel Constriction Action Pathway Alcaftadine H1-Antihistamine Immune Response Action Pathway Alimemazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Alimemazine H1-Antihistamine Action Alimemazine H1-Antihistamine Blood Vessel Constriction Action Pathway Alimemazine H1-Antihistamine Immune Response Action Pathway Alverine Serotonin Antagonist Action Pathway Anisotropine Methylbromide M2 GI Tract Relaxation Action Pathway Antazoline H1 Antihistamine Smooth Muscle Relaxation Action Pathway Antazoline H1-Antihistamine Action Antazoline H1-Antihistamine Blood Vessel Constriction Action Pathway Antazoline H1-Antihistamine Immune Response Action Pathway Arformoterol Action Pathway Aripiprazole lauroxil H1 Antihistamine Smooth Muscle Relaxation Action Pathway Aripiprazole lauroxil H1-Antihistamine Blood Vessel Constriction Action Pathway Aripiprazole lauroxil H1-Antihistamine Immune Response Action Pathway Astemizole H1 Antihistamine Smooth Muscle Relaxation Action Pathway Astemizole H1-Antihistamine Action Astemizole H1-Antihistamine Blood Vessel Constriction Action Pathway Astemizole H1-Antihistamine Immune Response Action Pathway Atropine M1/3/5 Muscarinic Poisoning Action Pathway Azatadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Azatadine H1-Antihistamine Action Azatadine H1-Antihistamine Blood Vessel Constriction Action Pathway Azatadine H1-Antihistamine Immune Response Action Pathway Azelastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Azelastine H1-Antihistamine Action Azelastine H1-Antihistamine Blood Vessel Constriction Action Pathway Azelastine H1-Antihistamine Immune Response Action Pathway Bamipine H1-Antihistamine Action Benzquinamide H1 Antihistamine Smooth Muscle Relaxation Action Pathway Benzquinamide H1-Antihistamine Blood Vessel Constriction Action Pathway Benzquinamide H1-Antihistamine Immune Response Action Pathway Bepotastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Bepotastine H1-Antihistamine Action Bepotastine H1-Antihistamine Blood Vessel Constriction Action Pathway Bepotastine H1-Antihistamine Immune Response Action Pathway Betahistine H1-Antihistamine Action Bethanechol Action Pathway Bilastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Bilastine H1-Antihistamine Action Bilastine H1-Antihistamine Blood Vessel Constriction Action Pathway Bilastine H1-Antihistamine Immune Response Action Pathway Bromodiphenhydramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Bromodiphenhydramine H1-Antihistamine Action Bromodiphenhydramine H1-Antihistamine Blood Vessel Constriction Action Pathway Bromodiphenhydramine H1-Antihistamine Immune Response Action Pathway Brompheniramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Brompheniramine H1-Antihistamine Action Brompheniramine H1-Antihistamine Blood Vessel Constriction Action Pathway Brompheniramine H1-Antihistamine Immune Response Action Pathway Buclizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Buclizine H1-Antihistamine Action Buclizine H1-Antihistamine Blood Vessel Constriction Action Pathway Buclizine H1-Antihistamine Immune Response Action Pathway Butriptyline H1 Antihistamine Smooth Muscle Relaxation Action Pathway Butriptyline H1-Antihistamine Blood Vessel Constriction Action Pathway Butriptyline H1-Antihistamine Immune Response Action Pathway Cadmium Induces DNA Synthesis and Proliferation in Macrophages Carbinoxamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Carbinoxamine H1-Antihistamine Action Carbinoxamine H1-Antihistamine Blood Vessel Constriction Action Pathway Carbinoxamine H1-Antihistamine Immune Response Action Pathway Cariprazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Cariprazine H1-Antihistamine Blood Vessel Constriction Action Pathway Cariprazine H1-Antihistamine Immune Response Action Pathway Carteolol B1-Adrenergic Ciliary Muscle Contraction Action Pathway Carteolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Celiprolol B2-Adrenergic Vasodilation Action Pathway Cetirizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Cetirizine H1-Antihistamine Action Cetirizine H1-Antihistamine Blood Vessel Constriction Action Pathway Cetirizine H1-Antihistamine Immune Response Action Pathway Cevimeline M1 Saliva Excretion Action Pathway Cevimeline M3 Salivary Gland Smooth Muscle Contraction Action Pathway Chlorcyclizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Chlorcyclizine H1-Antihistamine Action Chlorcyclizine H1-Antihistamine Blood Vessel Constriction Action Pathway Chlorcyclizine H1-Antihistamine Immune Response Action Pathway Chloropyramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Chloropyramine H1-Antihistamine Action Chloropyramine H1-Antihistamine Blood Vessel Constriction Action Pathway Chloropyramine H1-Antihistamine Immune Response Action Pathway Chlorphenamine H1-Antihistamine Action Chlorpheniramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Chlorpheniramine H1-Antihistamine Blood Vessel Constriction Action Pathway Chlorpheniramine H1-Antihistamine Immune Response Action Pathway Chlorphenoxamine H1-Antihistamine Action Chlorpromazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Chlorpromazine H1-Antihistamine Blood Vessel Constriction Action Pathway Chlorpromazine H1-Antihistamine Immune Response Action Pathway Chlorprothixene H1 Antihistamine Smooth Muscle Relaxation Action Pathway Chlorprothixene H1-Antihistamine Blood Vessel Constriction Action Pathway Chlorprothixene H1-Antihistamine Immune Response Action Pathway Cinnarizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Cinnarizine H1-Antihistamine Action Cinnarizine H1-Antihistamine Blood Vessel Constriction Action Pathway Cinnarizine H1-Antihistamine Immune Response Action Pathway Clemastine H1-Antihistamine Blood Vessel Constriction Action Pathway Clemastine H1-Antihistamine Immune Response Action Pathway Clemastine H1-Antihistamine Smooth Muscle Relaxation Action Pathway Clenbuterol Action Pathway Clocinizine H1-Antihistamine Action Clofedanol H1 Antihistamine Smooth Muscle Relaxation Action Pathway Clofedanol H1-Antihistamine Blood Vessel Constriction Action Pathway Clofedanol H1-Antihistamine Immune Response Action Pathway Clozapine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Clozapine H1-Antihistamine Blood Vessel Constriction Action Pathway Clozapine H1-Antihistamine Immune Response Action Pathway Cyclizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Cyclizine H1-Antihistamine Action Cyclizine H1-Antihistamine Blood Vessel Constriction Action Pathway Cyclizine H1-Antihistamine Immune Response Action Pathway Cyproheptadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Cyproheptadine H1-Antihistamine Action Cyproheptadine H1-Antihistamine Blood Vessel Constriction Action Pathway Cyproheptadine H1-Antihistamine Immune Response Action Pathway Dalfampridine Action Pathway Darifenacin Action Pathway Deptropine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Deptropine H1-Antihistamine Action Deptropine H1-Antihistamine Blood Vessel Constriction Action Pathway Deptropine H1-Antihistamine Immune Response Action Pathway Desloratadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Desloratadine H1-Antihistamine Action Desloratadine H1-Antihistamine Blood Vessel Constriction Action Pathway Desloratadine H1-Antihistamine Immune Response Action Pathway Dexbrompheniramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Dexbrompheniramine H1-Antihistamine Action Dexbrompheniramine H1-Antihistamine Blood Vessel Constriction Action Pathway Dexbrompheniramine H1-Antihistamine Immune Response Action Pathway Dexchlorpheniramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Dexchlorpheniramine H1-Antihistamine Action Dexchlorpheniramine H1-Antihistamine Blood Vessel Constriction Action Pathway Dexchlorpheniramine H1-Antihistamine Immune Response Action Pathway Dexchlorpheniramine maleate H1 Antihistamine Smooth Muscle Relaxation Action Pathway Dexchlorpheniramine maleate H1-Antihistamine Blood Vessel Constriction Action Pathway Dexchlorpheniramine maleate H1-Antihistamine Immune Response Action Pathway Dimenhydrinate H1 Antihistamine Smooth Muscle Relaxation Action Pathway Dimenhydrinate H1-Antihistamine Blood Vessel Constriction Action Pathway Dimenhydrinate H1-Antihistamine Immune Response Action Pathway Dimetindene H1 Antihistamine Smooth Muscle Relaxation Action Pathway Dimetindene H1-Antihistamine Action Dimetindene H1-Antihistamine Blood Vessel Constriction Action Pathway Dimetindene H1-Antihistamine Immune Response Action Pathway Dimetotiazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Dimetotiazine H1-Antihistamine Blood Vessel Constriction Action Pathway Dimetotiazine H1-Antihistamine Immune Response Action Pathway Diphenhydramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Diphenhydramine H1-Antihistamine Action Diphenhydramine H1-Antihistamine Blood Vessel Constriction Action Pathway Diphenhydramine H1-Antihistamine Immune Response Action Pathway Diphenylpyraline H1 Antihistamine Smooth Muscle Relaxation Action Pathway Diphenylpyraline H1-Antihistamine Action Diphenylpyraline H1-Antihistamine Blood Vessel Constriction Action Pathway Diphenylpyraline H1-Antihistamine Immune Response Action Pathway Dipivefrin B2-Adrenergic Ciliary Muscle Relaxation Action Pathway Domperidone Mechanism of Action Action Pathway Doxepin H1 Antihistamine Smooth Muscle Relaxation Action Pathway Doxepin H1-Antihistamine Action Doxepin H1-Antihistamine Blood Vessel Constriction Action Pathway Doxepin H1-Antihistamine Immune Response Action Pathway Doxylamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Doxylamine H1-Antihistamine Blood Vessel Constriction Action Pathway Doxylamine H1-Antihistamine Immune Response Action Pathway Drotaverine Action Pathway Droxidopa A1-Adrenergic Vasoconstriction Action Pathway Droxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway Droxidopa B2-Adrenergic Artery Dilation Action Pathway Ebastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Ebastine H1-Antihistamine Action Ebastine H1-Antihistamine Blood Vessel Constriction Action Pathway Ebastine H1-Antihistamine Immune Response Action Pathway Embramine H1-Antihistamine Action Emedastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Emedastine H1-Antihistamine Action Emedastine H1-Antihistamine Blood Vessel Constriction Action Pathway Emedastine H1-Antihistamine Immune Response Action Pathway Ephedrine A1-Adrenergic Vasoconstriction Action Pathway Ephedrine B2-Adrenergic Bronchodilation Action Pathway Ephedrine B2-Adrenergic Vasodilation Action Pathway Epinastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Epinastine H1-Antihistamine Action Epinastine H1-Antihistamine Blood Vessel Constriction Action Pathway Epinastine H1-Antihistamine Immune Response Action Pathway Esmirtazapine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Esmirtazapine H1-Antihistamine Blood Vessel Constriction Action Pathway Esmirtazapine H1-Antihistamine Immune Response Action Pathway Etafedrine Action Pathway Fenethazine H1-Antihistamine Action Fenoldopam Mechanism of Action Action Pathway Fenoterol Action Pathway Fesoterodine Action Pathway Fexofenadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Fexofenadine H1-Antihistamine Action Fexofenadine H1-Antihistamine Blood Vessel Constriction Action Pathway Fexofenadine H1-Antihistamine Immune Response Action Pathway Flavoxate Action Pathway Flunarizine H1-Antihistamine Action Formoterol Action Pathway G-Protein Signaling Through Tubby Proteins Gi Adrenergic Smooth Muscle Contraction GnRH Signaling Pathway Gq Adrenergic Smooth Muscle Contraction Gq Histaminic Smooth Muscle Contraction Gq Muscarinic Smooth Muscle Contraction Gs Adrenergic Smooth Muscle Relaxation Gs Histaminic Smooth Muscle Relaxation GSK-1004723 H1 Antihistamine Smooth Muscle Relaxation Action Pathway GSK-1004723 H1-Antihistamine Blood Vessel Constriction Action Pathway GSK-1004723 H1-Antihistamine Immune Response Action Pathway Histamine H1 Receptor Activation Histamine Muscle Contraction Pathway Histapyrrodine H1-Antihistamine Action Homochlorcyclizine H1-Antihistamine Action Hydroxyethylpromethazine H1-Antihistamine Action Hydroxyzine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Hydroxyzine H1-Antihistamine Action Hydroxyzine H1-Antihistamine Blood Vessel Constriction Action Pathway Hydroxyzine H1-Antihistamine Immune Response Action Pathway Hyoscyamine M2 Smooth Muscle Relaxation Action Pathway Incretins - Insulin release Pathway Indacaterol Action Pathway Intestinal Serotonin pathway Ipratropium M3 Bronchodilation Action Pathway Isoetharine Action Pathway Isothipendyl H1 Antihistamine Smooth Muscle Relaxation Action Pathway Isothipendyl H1-Antihistamine Action Isothipendyl H1-Antihistamine Blood Vessel Constriction Action Pathway Isothipendyl H1-Antihistamine Immune Response Action Pathway Joubert Syndrome Joubert Syndrome Ketotifen H1 Antihistamine Smooth Muscle Relaxation Action Pathway Ketotifen H1-Antihistamine Action Ketotifen H1-Antihistamine Blood Vessel Constriction Action Pathway Ketotifen H1-Antihistamine Immune Response Action Pathway Latrepirdine H1-Antihistamine Action Levocabastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Levocabastine H1-Antihistamine Action Levocabastine H1-Antihistamine Blood Vessel Constriction Action Pathway Levocabastine H1-Antihistamine Immune Response Action Pathway Levocetirizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Levocetirizine H1-Antihistamine Action Levocetirizine H1-Antihistamine Blood Vessel Constriction Action Pathway Levocetirizine H1-Antihistamine Immune Response Action Pathway Levosalbutamol Action Pathway Loratadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Loratadine H1-Antihistamine Action Loratadine H1-Antihistamine Blood Vessel Constriction Action Pathway Loratadine H1-Antihistamine Immune Response Action Pathway Lysophosphatidic Acid LPA1 Signalling Lysophosphatidic Acid LPA2 Signalling Lysophosphatidic Acid LPA3 Signalling Lysophosphatidic Acid LPA4 Signalling Lysophosphatidic Acid LPA5 Signalling Magnesium Sulfate Action Pathway Mebhydrolin H1-Antihistamine Action Meclizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Meclizine H1-Antihistamine Action Meclizine H1-Antihistamine Blood Vessel Constriction Action Pathway Meclizine H1-Antihistamine Immune Response Action Pathway Mepyramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Mepyramine H1-Antihistamine Action Mepyramine H1-Antihistamine Blood Vessel Constriction Action Pathway Mepyramine H1-Antihistamine Immune Response Action Pathway Mequitazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Mequitazine H1-Antihistamine Action Mequitazine H1-Antihistamine Blood Vessel Constriction Action Pathway Mequitazine H1-Antihistamine Immune Response Action Pathway Methacholine M2 Bronchoconstriction Action Pathway Methacholine M3 Bronchoconstriction Action Pathway Methapyrilene H1 Antihistamine Smooth Muscle Relaxation Action Pathway Methapyrilene H1-Antihistamine Action Methapyrilene H1-Antihistamine Blood Vessel Constriction Action Pathway Methapyrilene H1-Antihistamine Immune Response Action Pathway Methdilazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Methdilazine H1-Antihistamine Action Methdilazine H1-Antihistamine Blood Vessel Constriction Action Pathway Methdilazine H1-Antihistamine Immune Response Action Pathway Methyldopa Action Pathway Methylergometrine Mechanism of Action Action Pathway Metipranolol Action Pathway (New) Mianserin H1 Antihistamine Smooth Muscle Relaxation Action Pathway Mianserin H1-Antihistamine Blood Vessel Constriction Action Pathway Mianserin H1-Antihistamine Immune Response Action Pathway Mirabegron Action Pathway Mirtazapine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Mirtazapine H1-Antihistamine Action Mirtazapine H1-Antihistamine Blood Vessel Constriction Action Pathway Mirtazapine H1-Antihistamine Immune Response Action Pathway Mizolastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Mizolastine H1-Antihistamine Action Mizolastine H1-Antihistamine Blood Vessel Constriction Action Pathway Mizolastine H1-Antihistamine Immune Response Action Pathway Muscular Gi Protein Cascade Muscular Gq Protien Cascade Muscular Gs Protein Cascade Nadolol B2-Adrenergic Vasoconstriction Action Pathway Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Action Pathway Norepinephrine B2-Adrenergic Artery Dilation Action Pathway Nylidrin Action Pathway Olanzapine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Olanzapine H1-Antihistamine Blood Vessel Constriction Action Pathway Olanzapine H1-Antihistamine Immune Response Action Pathway Olodaterol Action Pathway Olopatadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Olopatadine H1-Antihistamine Action Olopatadine H1-Antihistamine Blood Vessel Constriction Action Pathway Olopatadine H1-Antihistamine Immune Response Action Pathway Orciprenaline Action Pathway Orphenadrine Drug Action Orphenadrine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Orphenadrine H1-Antihistamine Blood Vessel Constriction Action Pathway Orphenadrine H1-Antihistamine Immune Response Action Pathway Oxatomide H1 Antihistamine Smooth Muscle Relaxation Action Pathway Oxatomide H1-Antihistamine Action Oxatomide H1-Antihistamine Blood Vessel Constriction Action Pathway Oxatomide H1-Antihistamine Immune Response Action Pathway Oxomemazine H1-Antihistamine Action Oxprenolol B2-Adrenergic Vasoconstriction Action Pathway Oxybutynin Action Pathway Oxyphenonium Action Pathway Oxytocin Action Pathway Pancreas Function - Beta Cell Phenbenzamine H1-Antihistamine Action Phenindamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Phenindamine H1-Antihistamine Action Phenindamine H1-Antihistamine Blood Vessel Constriction Action Pathway Phenindamine H1-Antihistamine Immune Response Action Pathway Pheniramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Pheniramine H1-Antihistamine Action Pheniramine H1-Antihistamine Blood Vessel Constriction Action Pathway Pheniramine H1-Antihistamine Immune Response Action Pathway Phenylephrine Action Pathway Phenyltoloxamine H1-Antihistamine Action Phosphatidylinositol Phosphate Metabolism Phospholipase C Signaling Pathway Pilocarpine Action Pathway Pilocarpine M1 Saliva Excretion Action Pathway Pilocarpine M2 Ciliary Muscle Contraction Action Pathway Pilocarpine M3 Iris Sphincter Muscle Constriction Action Pathway Pimethixene H1-Antihistamine Action Pindolol B2-Adrenergic Vasodilation Action Pathway Pirbuterol Action Pathway Prazosin Action Pathway Procaterol Action Pathway Procyclidine M1 Antispasmodic Action Pathway Profenamine Action Pathway Promazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Promazine H1-Antihistamine Blood Vessel Constriction Action Pathway Promazine H1-Antihistamine Immune Response Action Pathway Promethazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Promethazine H1-Antihistamine Action Promethazine H1-Antihistamine Blood Vessel Constriction Action Pathway Promethazine H1-Antihistamine Immune Response Action Pathway Propantheline Action Pathway Propiomazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Propiomazine H1-Antihistamine Action Propiomazine H1-Antihistamine Blood Vessel Constriction Action Pathway Propiomazine H1-Antihistamine Immune Response Action Pathway Propiverine Action Pathway Propranolol B2-Adrenergic Vasoconstriction Action Pathway Pseudoephedrine Action Pathway Pyrrobutamine H1-Antihistamine Action Quetiapine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Quetiapine H1-Antihistamine Action Quetiapine H1-Antihistamine Blood Vessel Constriction Action Pathway Quetiapine H1-Antihistamine Immune Response Action Pathway Quifenadine H1-Antihistamine Action Racepinephrine A1-Adrenergic Vasoconstriction Action Pathway Racepinephrine B2-Adrenergic Bronchodilation Action Pathway Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway Rupatadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Rupatadine H1-Antihistamine Action Rupatadine H1-Antihistamine Blood Vessel Constriction Action Pathway Rupatadine H1-Antihistamine Immune Response Action Pathway Salbutamol Action Pathway Salmeterol Action Pathway Solifenacin M3 Bladder Muscle Relaxation Action Pathway Succinate Immunometabolism Pathway Succinate Signalling During Inflammation Talastine H1-Antihistamine Action Tamsulosin Action Pathway Temelastine H1-Antihistamine Action Terbutaline Action Pathway Terfenadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Terfenadine H1-Antihistamine Action Terfenadine H1-Antihistamine Blood Vessel Constriction Action Pathway Terfenadine H1-Antihistamine Immune Response Action Pathway Thenalidine H1-Antihistamine Action Thenyldiamine H1-Antihistamine Action Thiazinamium H1-Antihistamine Action Thonzylamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Thonzylamine H1-Antihistamine Action Thonzylamine H1-Antihistamine Blood Vessel Constriction Action Pathway Thonzylamine H1-Antihistamine Immune Response Action Pathway Timolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway Tolpropamine H1-Antihistamine Action Tolterodine Action Pathway Trazodone H1 Antihistamine Smooth Muscle Relaxation Action Pathway Trazodone H1-Antihistamine Blood Vessel Constriction Action Pathway Trazodone H1-Antihistamine Immune Response Action Pathway Trimebutine M3 Receptor Intestine Relaxation Action Pathway Tripelennamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Tripelennamine H1-Antihistamine Action Tripelennamine H1-Antihistamine Blood Vessel Constriction Action Pathway Tripelennamine H1-Antihistamine Immune Response Action Pathway Triprolidine H1 Antihistamine Smooth Muscle Relaxation Action Pathway Triprolidine H1-Antihistamine Action Triprolidine H1-Antihistamine Blood Vessel Constriction Action Pathway Triprolidine H1-Antihistamine Immune Response Action Pathway Tritoqualine H1-Antihistamine Action Trospium Action Pathway Vibegron Action Pathway Vilanterol Action Pathway Vorapaxar Action Pathway Ziprasidone H1 Antihistamine Smooth Muscle Relaxation Action Pathway Ziprasidone H1-Antihistamine Blood Vessel Constriction Action Pathway Ziprasidone H1-Antihistamine Immune Response Action Pathway Zuclopenthixol H1 Antihistamine Smooth Muscle Relaxation Action Pathway Zuclopenthixol H1-Antihistamine Blood Vessel Constriction Action Pathway Zuclopenthixol H1-Antihistamine Immune Response Action Pathway ( show more show less )
P10894 View in UniProt	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Gene Name: PLCB1 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Metabolic	Activation of PKC Through G Protein-Coupled Receptor Cadmium Induces DNA Synthesis and Proliferation in Macrophages G-Protein Signaling Through Tubby Proteins Gi Adrenergic Smooth Muscle Contraction GnRH Signaling Pathway Gq Adrenergic Smooth Muscle Contraction Gq Histaminic Smooth Muscle Contraction Gq Muscarinic Smooth Muscle Contraction Gq Serotonergic Smooth Muscle Contraction Gq Serotonergic Smooth Muscle Contraction Gs Adrenergic Smooth Muscle Relaxation Gs Histaminic Smooth Muscle Relaxation Histamine - H1 Dilation Pathway Histamine H1 Receptor Activation Histamine Immune Response Pathway Histamine Muscle Contraction Pathway Incretins - Insulin release Pathway Lysophosphatidic Acid LPA1 Signalling Lysophosphatidic Acid LPA2 Signalling Lysophosphatidic Acid LPA3 Signalling Lysophosphatidic Acid LPA4 Signalling Lysophosphatidic Acid LPA5 Signalling Muscle/Heart Contraction Muscular Gi Protein Cascade Muscular Gq Protien Cascade Muscular Gs Protein Cascade Neuronal serotonin Gq protein cascade Phosphatidylinositol Phosphate Metabolism Phospholipase C Signaling Pathway Phospholipase C Signaling Pathway Succinate Signalling During Inflammation ( show more show less )
Q9VPN9 View in UniProt	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II Gene Name: Plc21C The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Metabolic	Phosphatidylinositol Phosphate Metabolism
A2VDM2 View in UniProt	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Gene Name: PLCD1 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.	Metabolic	Inositol Metabolism
Q9QVD5 View in UniProt	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Gene Name: Plcd1 The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.	Metabolic	Inositol Metabolism
Q8BL19 View in UniProt	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Gene Name: Plcd3 Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.	Metabolic	Inositol Metabolism
Q8N3E9 View in UniProt HMDBP04457 View in HMDB	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Gene Name: PLCD3 Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.	Metabolic	Inositol Metabolism
P08487 View in UniProt	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Gene Name: PLCG1 Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity).	Metabolic	BCR Signaling Pathway CXCR4 Signaling Pathway EGF Signalling Pathway EPO Signaling Pathway Fc Epsilon Receptor I Signaling in Mast Cells Growth Hormone Signaling Pathway Ion Channel and Phorbal Esters Signaling Pathway Phospholipase C Signaling Pathway Phospholipase C Signaling Pathway T Cell Receptor Signaling Pathway ( show more show less )
P19174 View in UniProt HMDBP00244 View in HMDB	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Gene Name: PLCG1 Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.	Metabolic	BCR Signaling Pathway CXCR4 Signaling Pathway Cyclosporin A Action Pathway EGF Signalling Pathway EPO Signaling Pathway Fc Epsilon Receptor I Signaling in Mast Cells Growth Hormone Signaling Pathway Ion Channel and Phorbal Esters Signaling Pathway Phospholipase C Signaling Pathway T Cell Receptor Signaling Pathway Tacrolimus Action Pathway ( show more show less )
P10686 View in UniProt	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Gene Name: Plcg1 Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity).	Metabolic	BCR Signaling Pathway CXCR4 Signaling Pathway EGF Signalling Pathway EPO Signaling Pathway Fc Epsilon Receptor I Signaling in Mast Cells Growth Hormone Signaling Pathway Ion Channel and Phorbal Esters Signaling Pathway Phospholipase C Signaling Pathway Phospholipase C Signaling Pathway T Cell Receptor Signaling Pathway ( show more show less )
Q6P1G1 View in UniProt	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Gene Name: Plcg1 Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.	Metabolic	BCR Signaling Pathway CXCR4 Signaling Pathway EGF Signalling Pathway EPO Signaling Pathway Fc Epsilon Receptor I Signaling in Mast Cells Growth Hormone Signaling Pathway Ion Channel and Phorbal Esters Signaling Pathway Phospholipase C Signaling Pathway Phospholipase C Signaling Pathway T Cell Receptor Signaling Pathway ( show more show less )
Q9Y2I7 View in UniProt HMDBP01276 View in HMDB	1-phosphatidylinositol-3-phosphate 5-kinase Gene Name: PIKFYVE The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol-3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol-3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes	Metabolic	Inositol Metabolism Joubert Syndrome Joubert Syndrome Phosphatidylinositol Phosphate Metabolism

Showing 61 - 80 of 9284 proteins

Browsing Proteins

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Protein ID

Protein Description

Pathway Class

Pathways

P77488

1-deoxy-D-xylulose-5-phosphate synthase

Q9CU94

1-phosphatidylinositol 3-phosphate 5-kinase

P34756

1-phosphatidylinositol 3-phosphate 5-kinase FAB1

Q9W4K9

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase

P32383

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1

Q9U6B9

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8

P10687

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Q9Z2T5

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Q9NQ66

HMDBP00222

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

P10894

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Q9VPN9

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II

A2VDM2

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Q9QVD5

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

Q8BL19

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

Q8N3E9

HMDBP04457

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

P08487

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

P19174

HMDBP00244

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

P10686

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Q6P1G1

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Q9Y2I7

HMDBP01276

1-phosphatidylinositol-3-phosphate 5-kinase