Browsing Search Results

Matched Description: platelets. Ticlopidine is taken orally and is a prodrug that must be metabolically activated before it can … be effective. It first enters the liver and enters the endoplasmic reticulum where it is metabolized … to form the active metabolite. First, it is catalyzed by cytochromes P450 2C19, 2B6 and 1A2 into 2 … -oxoclopidogrel. Secondly, it is processed by cytochromes P450 2B6, 2C9, 2C19, 3A4, 3A5, and serum … surface of platelet cells, preventing ADP from binding to and activating it. Clopidogrel prevents the

Matched Description: molecules. It is produced by some plants, bacteria, fungi and invertebrates, and can be used as a … source of energy, such as for flight in insects, and as a survival mechanism to avoid freezing and … stream, and is transported to liver hepatocytes. Once in the liver, glucokinase can use the energy and

Matched Description: Plastoquinol-9 biosynthesis is a pathway that begins in the cytosol and endoplasmic reticulum and … ends in the chloroplast by which L-tyrosine and geranylgeranyl diphosphate become plastoquinol-9 … , ubiquinone analogs and benzoquinone electron carriers. The subpathway that synthesizes homogentisate … endoplasmic reticulum and the single reaction is catalyzed by solanesyl diphosphate which requires a … , homogentisate solanesyltransferase catalyzes the conversion of solanesyl diphosphate and

Matched Description: alpha-Linolenic acid is a poly-unsaturated fatty acid with an 18-carbon chain and three cis double … , heat acclimation, and oxidative stress. alpha-Linolenic acid is released from the hydrolysis of a … alpha-linolenic acid to 13(S)-HPOT is the first step in the jasmonic acid synthesis and leads to … that separate pathway. 2(R)-HPOT is formed in an oil body and undergoes a spontaneous decarboxylation … to form a heptadecatrienal. 9(S)-HPOT, or 13(S)-HPOT are both formed in a chloroplast and cleaved

Matched Description: molecules. It is produced by some plants, bacteria, fungi and invertebrates, and can be used as a … source of energy, such as for flight in insects, and as a survival mechanism to avoid freezing and … stream, and is transported to liver hepatocytes. Once in the liver, glucokinase can use the energy and

Matched Description: -dimensional conformation) and DNA repairs. During these processes, DNA topoisomerase I creates reversible … single-stranded breaks in DNA, allowing intact single DNA strands to pass through the break and … relieve the topologic constraints. After DNA is sufficiently relaxed and the strand passage reaction is … . Topotecan binds to the topoisomerase I-DNA complex and prevents the religation of the single strand … breaks and of any breaks in the DNA. This ternary complex interferes with the moving replication

Matched Description: under the brand names Gilurytmal, Ritmos, and Aritmina. An alkaloid found in the root of Rauwolfia … changing the shape and threshold of cardiac action potentials. Ajmaline produces potent sodium channel … blocking effects and a very short half-life which makes it a very useful drug for acute intravenous … fibrillation in patients with the Wolff–Parkinson–White syndrome and in well tolerated monomorphic ventricular … the heart in cases of bundle branch block and syncope. In these cases, abnormal prolongation of the

Matched Description: molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli … to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they are … bound to GTP, they are 'on', and, when they are bound to GDP, they are 'off'. G proteins belong to … to a domain of the GPCR located outside the cell, and an intracellular GPCR domain then in turn … protein-coupled receptors and G proteins working together transmit signals from many hormones

Matched Description: molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli … to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they are … bound to GTP, they are 'on', and, when they are bound to GDP, they are 'off'. G proteins belong to … to a domain of the GPCR located outside the cell, and an intracellular GPCR domain then in turn … protein-coupled receptors and G proteins working together transmit signals from many hormones

Matched Description: binds to specific promoter regions of target genes and activates the expression of key genes within the … alginate biosynthetic operon (alg) and the poly-β-1,6-N-acetyl-D-glucosamine (PGA) operon. The alg … accumulates and activates LasR, it triggers a regulatory cascade that enhances the expression of both operons … , leading to increased biofilm integrity and stability. This dual regulation not only promotes the … stresses and antimicrobial agents, underscoring the importance of quorum sensing in microbial community dynamics and biofilm formation.