SMP0126130
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Valrubicin Action Pathway
Homo sapiens
Matched Description: is used to treat BCG-resistant bladder carcinoma and is administered directly in the bladder … nucleosides into nucleic acids, causes extensive chromosomal damage, and arrests the cell cycle in the … /uncoiling of DNA, and inhibition of DNA and RNA synthesis. DNA damage leads to programmed cell death … (apoptosis) of the cancer cells, preventing the growth and proliferation of cancer in patients.
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SMP0126274
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Lamotrigine Action Pathway
Homo sapiens
Matched Description: Lamotrigine is a phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I … and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium … granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It … conditions. Although chemically unrelated, lamotrigine actions resemble those of phenytoin and … lamotrigine may include headaches, drowsiness, aggression, and tremors.
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SMP0121221
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Melanin Biosynthesis
Danio rerio
Matched Description: Melanin is used in the skin of zebrafish for camouflage, mimicry, communication and protection from … the skin cells. Eumelanins are brown and black pigments, while other melanins exist, pheomelanin being … yellow and red pigments, and neuromelanin being used in the brain. All of these pigments require … by an amino acid transporter, and at this point it is metabolized to L-dopachrome . Within the
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SMP0471241
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Uracil Degradation III
Fusobacterium periodonticum 1_1_41FAA
Matched Description: Uracil is a pyrimidine nucleobase found in RNA, and can be used as a source of nitrogen for E. coli … broken down into both carbamic acid and 3-aminoacrylate following the addition of a water molecule by the … addition of a hydrogen ion, split into an ammonium ion and a molecule of carbon dioxide. 3-aminoacrylate … compound enters into a reaction catalyzed by protein rutD, which adds a water molecule and hydrogen ion … and forms malonic semialdehyde with ammonium being a byproduct. Finally, the putative NADH
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SMP0645571
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Uracil Degradation III
Prevotella intermedia ATCC 25611 = DSM 20706
Matched Description: Uracil is a pyrimidine nucleobase found in RNA, and can be used as a source of nitrogen for E. coli … broken down into both carbamic acid and 3-aminoacrylate following the addition of a water molecule by the … addition of a hydrogen ion, split into an ammonium ion and a molecule of carbon dioxide. 3-aminoacrylate … compound enters into a reaction catalyzed by protein rutD, which adds a water molecule and hydrogen ion … and forms malonic semialdehyde with ammonium being a byproduct. Finally, the putative NADH
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SMP0645610
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Uracil Degradation III
Helicobacter cinaedi CCUG 18818 = ATCC BAA-847
Matched Description: Uracil is a pyrimidine nucleobase found in RNA, and can be used as a source of nitrogen for E. coli … broken down into both carbamic acid and 3-aminoacrylate following the addition of a water molecule by the … addition of a hydrogen ion, split into an ammonium ion and a molecule of carbon dioxide. 3-aminoacrylate … compound enters into a reaction catalyzed by protein rutD, which adds a water molecule and hydrogen ion … and forms malonic semialdehyde with ammonium being a byproduct. Finally, the putative NADH
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SMP0471050
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Uracil Degradation III
Alistipes putredinis DSM 17216
Matched Description: Uracil is a pyrimidine nucleobase found in RNA, and can be used as a source of nitrogen for E. coli … broken down into both carbamic acid and 3-aminoacrylate following the addition of a water molecule by the … addition of a hydrogen ion, split into an ammonium ion and a molecule of carbon dioxide. 3-aminoacrylate … compound enters into a reaction catalyzed by protein rutD, which adds a water molecule and hydrogen ion … and forms malonic semialdehyde with ammonium being a byproduct. Finally, the putative NADH
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SMP0645672
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Uracil Degradation III
Acinetobacter johnsonii SH046
Matched Description: Uracil is a pyrimidine nucleobase found in RNA, and can be used as a source of nitrogen for E. coli … broken down into both carbamic acid and 3-aminoacrylate following the addition of a water molecule by the … addition of a hydrogen ion, split into an ammonium ion and a molecule of carbon dioxide. 3-aminoacrylate … compound enters into a reaction catalyzed by protein rutD, which adds a water molecule and hydrogen ion … and forms malonic semialdehyde with ammonium being a byproduct. Finally, the putative NADH
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SMP0645567
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Uracil Degradation III
Paraprevotella xylaniphila YIT 11841
Matched Description: Uracil is a pyrimidine nucleobase found in RNA, and can be used as a source of nitrogen for E. coli … broken down into both carbamic acid and 3-aminoacrylate following the addition of a water molecule by the … addition of a hydrogen ion, split into an ammonium ion and a molecule of carbon dioxide. 3-aminoacrylate … compound enters into a reaction catalyzed by protein rutD, which adds a water molecule and hydrogen ion … and forms malonic semialdehyde with ammonium being a byproduct. Finally, the putative NADH
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SMP0470805
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Uracil Degradation III
Paraprevotella clara YIT 11840
Matched Description: Uracil is a pyrimidine nucleobase found in RNA, and can be used as a source of nitrogen for E. coli … broken down into both carbamic acid and 3-aminoacrylate following the addition of a water molecule by the … addition of a hydrogen ion, split into an ammonium ion and a molecule of carbon dioxide. 3-aminoacrylate … compound enters into a reaction catalyzed by protein rutD, which adds a water molecule and hydrogen ion … and forms malonic semialdehyde with ammonium being a byproduct. Finally, the putative NADH
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