C-1-tetrahydrofolate synthase, cytoplasmic
Folylpolyglutamate synthase, mitochondrial
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Methionyl-tRNA formyltransferase, mitochondrial
Monofunctional C1-tetrahydrofolate synthase, mitochondrial
5,10-Methylene-THF + NADH → 5-Methyltetrahydrofolic acid + NAD
5-Formiminotetrahydrofolic acid ↔ 5,10-Methenyltetrahydrofolic acid + Ammonia
Adenosine triphosphate + N5-Formyl-THF → 5,10-Methenyltetrahydrofolic acid + Adenosine diphosphate + Phosphate
5,10-Methenyltetrahydrofolic acid + NADPH ↔ 5,10-Methylene-THF + NADP
L-Glutamic acid + N5-Formyl-THF → N-Formyl-L-glutamic acid + Tetrahydrofolic acid
10-Formyltetrahydrofolate + Hydrogen Ion ↔ 5,10-Methenyltetrahydrofolic acid + Water
Adenosine triphosphate + Formic acid + Tetrahydrofolic acid → 10-Formyltetrahydrofolate + Adenosine diphosphate + Phosphate
10-Formyltetrahydrofolate + NADP + Water → Carbon dioxide + NADPH + Tetrahydrofolic acid
NADP + Tetrahydrofolic acid ↔ Dihydrofolic acid + NADPH
Dihydrofolic acid + NADP ↔ Folic acid + NADPH
Folic acid (↔) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm
Tetrahydrofolic acid (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Mitochondrion
Adenosine triphosphate + L-Glutamic acid + Tetrahydrofolic acid → Adenosine diphosphate + Phosphate + Tetrahydrofolyl-[Glu](2)
10-Formyltetrahydrofolate + L-Methionyl-tRNA(Met) → N-formylmethionyl-tRNA(fMet) + Tetrahydrofolic acid
5,10-Methenyltetrahydrofolic acid + NADH ↔ 5,10-Methylene-THF + NAD
Adenosine triphosphate + L-Glutamic acid + Tetrahydrofolyl-[Glu](2) → Adenosine diphosphate + Phosphate + Tetrahydrofolyl-[Glu](n)
Tetrahydrofolyl-[Glu](n) + Water → L-Glutamic acid + Tetrahydrofolyl-[Glu](2)