L-Tryptophan + Oxygen → N'-Formylkynurenine
L-Tryptophan (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
L-3-Hydroxykynurenine + Oxoglutaric acid → 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid + L-Glutamic acid
L-3-Hydroxykynurenine + Water → 3-Hydroxyanthranilic acid + L-Alanine
2 3-Hydroxyanthranilic acid + Oxygen → Cinnavalininate + 2 Water
4-(2-Aminophenyl)-2,4-dioxobutanoic acid → Kynurenic acid
L-Kynurenine + NADPH + Oxygen → L-3-Hydroxykynurenine + NADP + Water
L-Kynurenine + Water → 2-Aminobenzoic acid + L-Alanine
L-Kynurenine + Oxoglutaric acid → 4-(2-Aminophenyl)-2,4-dioxobutanoic acid + L-Glutamic acid
N'-Formylkynurenine + Water → Formic acid + L-Kynurenine
Formylanthranilic acid + Water → 2-Aminobenzoic acid + Formic acid
N'-Formylkynurenine + Water → Formylanthranilic acid + L-Alanine
Melatonin + Oxygen → Acetyl-N-formyl-5-methoxykynurenamine
N-Acetylserotonin + S-Adenosylmethionine → Melatonin + S-Adenosylhomocysteine
Melatonin + Oxygen + Reduced flavoprotein → 6-Hydroxymelatonin + Oxidized flavoprotein + Water
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
5-Hydroxykynurenamine + NADPH + Oxygen → 4,6-Dihydroxyquinoline + NADP + Water
Acetyl-CoA + Serotonin → Coenzyme A + N-Acetylserotonin
5-Hydroxy-N-formylkynurenine + Water → 5-Hydroxykynurenine + Formic acid
5-Hydroxykynurenine → 5-Hydroxykynurenamine + Carbon dioxide
5-Hydroxy-L-tryptophan + Oxygen → 5-Hydroxy-N-formylkynurenine
5-Hydroxyindoleacetic acid + S-Adenosylmethionine → 5-Methoxyindoleacetate + S-Adenosylhomocysteine
5-Hydroxyindoleacetaldehyde + NAD + Water → 5-Hydroxyindoleacetic acid + NADH
NADPH + Oxygen + Serotonin → 5-Hydroxyindoleacetaldehyde + NADP + Water
L-Tryptophan + Oxygen + Tetrahydrobiopterin → 4a-Hydroxytetrahydrobiopterin + 5-Hydroxy-L-tryptophan
5-Hydroxy-L-tryptophan → Carbon dioxide + Serotonin
2-Amino-3-carboxymuconic acid semialdehyde → Quinolinic acid
2-Amino-3-carboxymuconic acid semialdehyde → 2-Aminomuconic acid semialdehyde + Carbon dioxide
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid → Xanthurenic acid
3-Hydroxyanthranilic acid + Oxygen → 2-Amino-3-carboxymuconic acid semialdehyde
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
S-Adenosylmethionine + Tryptamine → N-Methyltryptamine + S-Adenosylhomocysteine
NADPH + Oxygen + Tryptamine → Indoleacetaldehyde + NADP + Water
Indoleacetaldehyde + NAD + Water → Indoleacetic acid + NADH
L-Tryptophan → Carbon dioxide + Tryptamine
S-Adenosylmethionine + Serotonin → N-Methylserotonin + S-Adenosylhomocysteine
Oxygen + Serotonin → Formyl-5-hydroxykynurenamine
4-(2-Aminophenyl)-2,4-dioxobutanoic acid
5-Hydroxyindoleacetaldehyde + Oxygen + Water → 5-Hydroxyindoleacetic acid + Hydrogen peroxide
Adenosine triphosphate + L-Tryptophan + tRNA(Trp) → Adenosine monophosphate + L-Tryptophyl-tRNA(Trp) + Pyrophosphate
2-Amino-3-carboxymuconic acid semialdehyde