Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/CAS 79551-86-3
type: UnificationXref
id: 79551-86-3
db: CAS

Arachidonic acid
type: SmallMoleculeReference
xref: Reference/CAS 506-32-1
xref: Reference/BioCyc ARACHIDONIC ACID
xref: Reference/ChEBI CHEBI 15843
xref: Reference/KEGG Compound C00219
xref: Reference/HMDB HMDB0001043
xref: Reference/ChemSpider 392692
xref: Reference/PubChem-compound 444899
chemical formula: C20H32O2
molecular weight: 304.24023
structure: ChemicalStructure/PW C000821

Protein/76 Endoplasmic Reticulum Membrane/Stoichiometry/3.0
type: Stoichiometry
physical entity: Prostaglandin E synthase
stoichiometric coefficient: 3.0

Reference/CAS 20559-16-4
type: UnificationXref
id: 20559-16-4
db: CAS

Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0061118
type: UnificationXref
id: HMDB0061118
db: HMDB

Reference/HMDB HMDB0061119
type: UnificationXref
id: HMDB0061119
db: HMDB

Compound/PW C002644 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 20-Carboxy-leukotriene B4
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0061377
type: UnificationXref
id: HMDB0061377
db: HMDB

Reference/KEGG Compound C04805
type: UnificationXref
id: C04805
db: KEGG Compound

14,15-Epoxy-5,8,11-eicosatrienoic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 14,15-Epoxy-5,8,11-eicosatrienoic acid

Reference/PubChem-compound 24778634
type: UnificationXref
id: 24778634
db: PubChem-compound

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADPH

Compound/PW C002105 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 12(S)-HPETE
stoichiometric coefficient: 1.0

Leukotriene B4
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Leukotriene B4

LysoPC(14:0/0:0)
type: SmallMoleculeReference
xref: Reference/CAS 20559-16-4
xref: Reference/KEGG Compound C04230
xref: Reference/HMDB HMDB0010379
xref: Reference/PubChem-compound 460604
xref: Reference/ChemSpider 405289
xref: Reference/BioCyc PHOSPHATIDYLCHOLINE
xref: Reference/ChEBI CHEBI 64489
chemical formula: C22H46NO7P
molecular weight: 467.30118
structure: ChemicalStructure/PW C006388

Cytochrome P450 4A11
type: ProteinReference
xref: Reference/UniProt Q02928
organism: Homo sapiens

Leukotriene A4
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Leukotriene A4

Reference/HMDB HMDB0003252
type: UnificationXref
id: HMDB0003252
db: HMDB

5,6-Epoxy-8,11,14-eicosatrienoic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 5,6-Epoxy-8,11,14-eicosatrienoic acid

Reference/UniProt P07203
type: UnificationXref
id: P07203
db: UniProt

Compound/PW C001986 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 15(S)-HETE
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Compound/PW C000933 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Leukotriene C4
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00219
type: UnificationXref
id: C00219
db: KEGG Compound

Compound/PW C001030 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Leukotriene A4
stoichiometric coefficient: 1.0

Reference/CAS 60203-57-8
type: UnificationXref
id: 60203-57-8
db: CAS

Reference/KEGG Compound C00696
type: UnificationXref
id: C00696
db: KEGG Compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/UniProt Q8TBF2
type: UnificationXref
id: Q8TBF2
db: UniProt

ChemicalStructure/PW C002179
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C[C@@H](OO)\C=C\C=C/C\C=C/CCCC(O)=O

ChemicalStructure/PW C006774
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/C=C/C(CCCC(O)=O)OO

ChemicalStructure/PW C006773
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/C=C/[C@@H](O)CCCC(O)=O

ChemicalStructure/PW C006776
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C006775
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

ChemicalStructure/PW C002171
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C=C/[C@@H](O)C\C=C/CCCC(O)=O

ChemicalStructure/PW C002172
type: ChemicalStructure
structure format: SMILES
structure data: CCCC[C@@H](O)\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

Reference/HMDB HMDB0001085
type: UnificationXref
id: HMDB0001085
db: HMDB

ChemicalStructure/PW C002174
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC[C@H](O)\C=C\C(O)C(O)C\C=C/C\C=C/CCCC(O)=O

ChemicalStructure/PW C001084
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P16152
type: UnificationXref
id: P16152
db: UniProt

ChemicalStructure/PW C002170
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C[C@H]1O[C@H]1C\C=C/C\C=C/CCCC(O)=O

Reference/HMDB HMDB0061111
type: UnificationXref
id: HMDB0061111
db: HMDB

Reference/KEGG Compound C01312
type: UnificationXref
id: C01312
db: KEGG Compound

ChemicalStructure/PW C002183
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C=C/[C@H](C\C=C/CCCC(O)=O)OO

ChemicalStructure/PW C002180
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCC1OC1\C=C\C(O)C\C=C/C\C=C/CCCC(O)=O

Reference/CAS 77667-09-5
type: UnificationXref
id: 77667-09-5
db: CAS

Compound/PW C001084 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin D2
stoichiometric coefficient: 1.0

ChemicalStructure/PW C002181
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCC(O)C(O)\C=C\C(O)C\C=C/C\C=C/CCCC(O)=O

Reference/CAS 58962-34-8
type: UnificationXref
id: 58962-34-8
db: CAS

6-Ketoprostaglandin E1
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 6-Ketoprostaglandin E1

Reference/PubChem-compound 5283154
type: UnificationXref
id: 5283154
db: PubChem-compound

Reference/PubChem-compound 5283155
type: UnificationXref
id: 5283155
db: PubChem-compound

Reference/HMDB HMDB0002190
type: UnificationXref
id: HMDB0002190
db: HMDB

Reference/PubChem-compound 5283156
type: UnificationXref
id: 5283156
db: PubChem-compound

Reference/PubChem-compound 124886
type: UnificationXref
id: 124886
db: PubChem-compound

L-Glutamic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamic acid

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 2.0

Reference/UniProt P51589
type: UnificationXref
id: P51589
db: UniProt

Reference/PubChem-compound 5283157
type: UnificationXref
id: 5283157
db: PubChem-compound

Reference/PubChem-compound 5283159
type: UnificationXref
id: 5283159
db: PubChem-compound

Compound/PW C002170 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11,12-Epoxyeicosatrienoic acid
stoichiometric coefficient: 1.0

Compound/PW C000949 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin E2
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0007883
type: UnificationXref
id: HMDB0007883
db: HMDB

Reference/PubChem-compound 9548884
type: UnificationXref
id: 9548884
db: PubChem-compound

Reference/PubChem-compound 9548883
type: UnificationXref
id: 9548883
db: PubChem-compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/PubChem-compound 9548885
type: UnificationXref
id: 9548885
db: PubChem-compound

Reference/PubChem-compound 5283142
type: UnificationXref
id: 5283142
db: PubChem-compound

Compound/PW C000821 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/PubChem-compound 5283144
type: UnificationXref
id: 5283144
db: PubChem-compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: NADP

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/PubChem-compound 9548880
type: UnificationXref
id: 9548880
db: PubChem-compound

Compound/PW C000933 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Leukotriene C4
stoichiometric coefficient: 1.0

6-Keto-prostaglandin F1a
type: SmallMoleculeReference
xref: Reference/CAS 58962-34-8
xref: Reference/ChEBI CHEBI 28158
xref: Reference/HMDB HMDB0002886
xref: Reference/ChemSpider 4444411
xref: Reference/KEGG Compound C05961
xref: Reference/PubChem-compound 5280888
chemical formula: C20H34O6
molecular weight: 370.23553
structure: ChemicalStructure/PW C001726

NADP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADP

Aldo-keto reductase family 1 member C3
type: ProteinReference
xref: Reference/UniProt P42330
organism: Homo sapiens

Reference/PubChem-compound 5283146
type: UnificationXref
id: 5283146
db: PubChem-compound

Reference/PubChem-compound 5283147
type: UnificationXref
id: 5283147
db: PubChem-compound

Reference/PubChem-compound 5283171
type: UnificationXref
id: 5283171
db: PubChem-compound

Reference/PubChem-compound 11954058
type: UnificationXref
id: 11954058
db: PubChem-compound

ReactionCatalysis2192
type: Catalysis
controller: Leukotriene-B(4) omega-hydroxylase 2
controlled: Reaction2296
control type: ACTIVATION

Reference/PubChem-compound 11954059
type: UnificationXref
id: 11954059
db: PubChem-compound

Reference/KEGG Compound C05949
type: UnificationXref
id: C05949
db: KEGG Compound

Reference/KEGG Compound C04853
type: UnificationXref
id: C04853
db: KEGG Compound

Reference/PubChem-compound 17395793
type: UnificationXref
id: 17395793
db: PubChem-compound

Reference/ChEBI CHEBI 28269
type: UnificationXref
id: CHEBI:28269
db: ChEBI

Reference/PubChem-compound 17395792
type: UnificationXref
id: 17395792
db: PubChem-compound

Cytochrome P450 2E1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 2E1

Compound/PW C001477 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5,6-Epoxy-8,11,14-eicosatrienoic acid
stoichiometric coefficient: 1.0

Compound/PW C002100 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: δ-12-Prostaglandin J2
stoichiometric coefficient: 1.0

Compound/PW C001562 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11,12-DiHETrE
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040451
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040450
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H]1O[C@H]1CCCC(O)=O

Reference/HMDB HMDB0061378
type: UnificationXref
id: HMDB0061378
db: HMDB

Reference/PubChem-compound 11954060
type: UnificationXref
id: 11954060
db: PubChem-compound

ChemicalStructure/PW C040453
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C[C@@H](O)\C=C\C=C/C\C=C/CCCC(O)=O

Reference/PubChem-compound 5283162
type: UnificationXref
id: 5283162
db: PubChem-compound

ChemicalStructure/PW C040452
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C[C@H](O)\C=C\C=C/C\C=C/CCCC(O)=O

Reference/KEGG Compound C05958
type: UnificationXref
id: C05958
db: KEGG Compound

Leukotriene B4
type: SmallMoleculeReference
xref: Reference/ChemSpider 4444132
xref: Reference/ChEBI CHEBI 15647
xref: Reference/BioCyc 6Z8E10E14Z-5S12R-512-DIHYDROXYI
xref: Reference/HMDB HMDB0001085
xref: Reference/CAS 71160-24-2
xref: Reference/PubChem-compound 5280492
xref: Reference/KEGG Compound C02165
chemical formula: C20H32O4
molecular weight: 336.23007
structure: ChemicalStructure/PW C000853

Reference/KEGG Compound C05957
type: UnificationXref
id: C05957
db: KEGG Compound

Reference/KEGG Compound C05959
type: UnificationXref
id: C05959
db: KEGG Compound

Reference/KEGG Compound C05954
type: UnificationXref
id: C05954
db: KEGG Compound

Reference/KEGG Compound C05953
type: UnificationXref
id: C05953
db: KEGG Compound

Reference/KEGG Compound C05956
type: UnificationXref
id: C05956
db: KEGG Compound

Reference/KEGG Compound C05955
type: UnificationXref
id: C05955
db: KEGG Compound

Reference/KEGG Compound C05950
type: UnificationXref
id: C05950
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/KEGG Compound C05951
type: UnificationXref
id: C05951
db: KEGG Compound

12-KETE
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 12-KETE

Compound/PW C002179 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 12(R)-HPETE
stoichiometric coefficient: 1.0

ChemicalStructure/PW C008524
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/CC(=O)\C=C\C=C/C\C=C/CCCC(O)=O

Compound/PW C001814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin G2
stoichiometric coefficient: 1.0

Compound/PW C040452 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 12(S)-HETE
stoichiometric coefficient: 1.0

Reference/BioCyc ALPHA11-ALPHA-EPOXY-15-HYDROXYTHROMBA
type: UnificationXref
id: ALPHA11-ALPHA-EPOXY-15-HYDROXYTHROMBA
db: BioCyc

Arachidonic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Arachidonic acid

Cytosolic phospholipase A2 beta
type: Protein
cellular location: Cytoplasm
entity reference: Cytosolic phospholipase A2 beta

15(S)-HPETE
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 15(S)-HPETE

Reference/CAS 87893-54-7
type: UnificationXref
id: 87893-54-7
db: CAS

8,9-Epoxyeicosatrienoic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 4446324
xref: Reference/ChEBI CHEBI 34490
xref: Reference/KEGG Compound C14769
xref: Reference/PubChem-compound 5283203
xref: Reference/HMDB HMDB0002232
xref: Reference/CAS 81246-85-7
chemical formula: C20H32O3
molecular weight: 320.23514
structure: ChemicalStructure/PW C001511

Reference/KEGG Compound C05965
type: UnificationXref
id: C05965
db: KEGG Compound

Reference/KEGG Compound C05964
type: UnificationXref
id: C05964
db: KEGG Compound

Reference/UniProt O75342
type: UnificationXref
id: O75342
db: UniProt

Reference/KEGG Compound C05966
type: UnificationXref
id: C05966
db: KEGG Compound

PC(14:0/20:4(5Z,8Z,11Z,14Z))
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24778634
xref: Reference/ChemSpider 24766559
xref: Reference/KEGG Compound C00157
xref: Reference/BioCyc PHOSPHATIDYLCHOLINE
xref: Reference/HMDB HMDB0007883
chemical formula: C42H76NO8P
molecular weight: 753.5309
structure: ChemicalStructure/PW C003933

ChemicalStructure/PW C002106
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC[C@H](OO)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O

Reference/KEGG Compound C05961
type: UnificationXref
id: C05961
db: KEGG Compound

Reference/KEGG Compound C05963
type: UnificationXref
id: C05963
db: KEGG Compound

Reference/KEGG Compound C05962
type: UnificationXref
id: C05962
db: KEGG Compound

ChemicalStructure/PW C002113
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCC1OC1C\C=C/C\C=C/C\C=C/CCCC(O)=O

Reference/HMDB HMDB0002314
type: UnificationXref
id: HMDB0002314
db: HMDB

PC(14:0/20:4(5Z,8Z,11Z,14Z))
type: SmallMolecule
cellular location: Cytoplasm
entity reference: PC(14:0/20:4(5Z,8Z,11Z,14Z))

Reference/HMDB HMDB0002311
type: UnificationXref
id: HMDB0002311
db: HMDB

Prostamide/prostaglandin F synthase
type: Protein
cellular location: Cytoplasm
entity reference: Prostamide/prostaglandin F synthase

Reference/HMDB HMDB0001220
type: UnificationXref
id: HMDB0001220
db: HMDB

Compound/PW C001162 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 20-Hydroxy-leukotriene B4
stoichiometric coefficient: 1.0

Leukotriene C4 synthase
type: Complex
component stoichiometry: Protein/752 Endoplasmic Reticulum Membrane/Stoichiometry/3.0
cellular location: Endoplasmic Reticulum Membrane
component: Leukotriene C4 synthase

ChemicalStructure/PW C001028
type: ChemicalStructure
structure format: SMILES

Compound/PW C002183 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 8(S)-HPETE
stoichiometric coefficient: 1.0

20-Hydroxyeicosatetraenoic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0005998
xref: Reference/KEGG Compound C14748
xref: Reference/CAS 79551-86-3
xref: Reference/ChEBI CHEBI 34306
xref: Reference/PubChem-compound 5283157
xref: Reference/ChemSpider 4446281
chemical formula: C20H32O3
molecular weight: 320.23514
structure: ChemicalStructure/PW C002614

Reference/PubChem-compound 460604
type: UnificationXref
id: 460604
db: PubChem-compound

14,15-DiHETrE
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5283147
xref: Reference/ChEBI CHEBI 63966
xref: Reference/HMDB HMDB0002265
xref: Reference/CAS 77667-09-5
xref: Reference/KEGG Compound C14775
xref: Reference/ChemSpider 4446271
chemical formula: C20H34O4
molecular weight: 338.2457
structure: ChemicalStructure/PW C001529

Reaction2296
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002614 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
right: Water
right: NADP
right: 20-Hydroxyeicosatetraenoic acid
spontaneous: false
left: Arachidonic acid
left: Oxygen
left: NADPH
name: Arachidonic acid + NADPH + Oxygen → 20-Hydroxyeicosatetraenoic acid + NADP + Water
conversion direction: LEFT_TO_RIGHT

Compound/PW C002614 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 20-Hydroxyeicosatetraenoic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00051
type: UnificationXref
id: C00051
db: KEGG Compound

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Compound/PW C001030 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Leukotriene A4
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001030
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C=C/C=C/[C@@H]1O[C@H]1CCCC(O)=O

Prostaglandin F2a
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15553
xref: Reference/ChemSpider 4446204
xref: Reference/BioCyc 5Z13E-15S-9-ALPHA11-ALPHA15-TRIHY
xref: Reference/HMDB HMDB0001139
xref: Reference/KEGG Compound C00639
xref: Reference/PubChem-compound 5283078
xref: Reference/CAS 551-11-1
chemical formula: C20H34O5
molecular weight: 354.24063
structure: ChemicalStructure/PW C000889

Reference/CAS 67675-13-2
type: UnificationXref
id: 67675-13-2
db: CAS

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Prostaglandin F2a
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Prostaglandin F2a

Leukotriene A4
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Leukotriene A4

12-Keto-leukotriene B4
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 12-Keto-leukotriene B4

Prostacyclin synthase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostacyclin synthase

Compound/PW C002171 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 8-HETE
stoichiometric coefficient: 1.0

Etodolac
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0014887
xref: Reference/ChemSpider 3192
xref: Reference/KEGG Compound C06991
xref: Reference/CAS 41340-25-4
xref: Reference/PubChem-compound 3308
xref: Reference/ChEBI CHEBI 4909
chemical formula: C17H21NO3
molecular weight: 287.15213
structure: ChemicalStructure/PW C009220

Reference/PubChem-compound 5283137
type: UnificationXref
id: 5283137
db: PubChem-compound

BiologicalState10
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver
tissue: Liver

Compound/PW C002113 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 14,15-Epoxy-5,8,11-eicosatrienoic acid
stoichiometric coefficient: 1.0

15(S)-HETE
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003876
xref: Reference/ChEBI CHEBI 15558
xref: Reference/CAS 54845-95-3
xref: Reference/KEGG Compound C04742
xref: Reference/PubChem-compound 5280724
xref: Reference/ChemSpider 4444307
chemical formula: C20H32O3
molecular weight: 320.23514
structure: ChemicalStructure/PW C001986

Compound/PW C002172 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 16(R)-HETE
stoichiometric coefficient: 1.0

Prostaglandin E2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin E2

ChemicalStructure/PW C002103
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002104
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C002105
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C[C@H](OO)\C=C\C=C/C\C=C/CCCC(O)=O

Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

ChemicalStructure/PW C002100
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC[C@H](O)C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O

8-Isoprostane
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 8-Isoprostane

Reference/HMDB HMDB0002343
type: UnificationXref
id: HMDB0002343
db: HMDB

Oxidized glutathione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxidized glutathione

Reference/UniProt P20813
type: UnificationXref
id: P20813
db: UniProt

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

11-Epi-PGF2a
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 11-Epi-PGF2a

Compound/PW C000146 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

20-Carboxy-leukotriene B4
type: SmallMoleculeReference
xref: Reference/CAS 80434-82-8
xref: Reference/ChemSpider 4444400
xref: Reference/HMDB HMDB0006059
xref: Reference/KEGG Compound C05950
xref: Reference/PubChem-compound 5280877
xref: Reference/ChEBI CHEBI 27562
chemical formula: C20H30O6
molecular weight: 366.20422
structure: ChemicalStructure/PW C002644

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

8,9-DiHETrE
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 63970
xref: Reference/HMDB HMDB0002311
xref: Reference/PubChem-compound 5283144
xref: Reference/ChemSpider 4446268
xref: Reference/CAS 192461-96-4
xref: Reference/KEGG Compound C14773
chemical formula: C20H34O4
molecular weight: 338.2457
structure: ChemicalStructure/PW C001561

11,12-DiHETrE
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002314
xref: Reference/ChEBI CHEBI 63969
xref: Reference/KEGG Compound C14774
xref: Reference/PubChem-compound 5283146
xref: Reference/CAS 192461-95-3
xref: Reference/ChemSpider 4446270
chemical formula: C20H34O4
molecular weight: 338.2457
structure: ChemicalStructure/PW C001562

Prostaglandin I2
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Prostaglandin I2

ChemicalStructure/PW C002398
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O

ChemicalStructure/PW C001068
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

5,6-Epoxy-8,11,14-eicosatrienoic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5,6-Epoxy-8,11,14-eicosatrienoic acid

Reference/CAS 81246-85-7
type: UnificationXref
id: 81246-85-7
db: CAS

Leukotriene C4 synthase
type: ProteinReference
xref: Reference/UniProt Q16873
organism: BiologicalState10

Reference/ChEBI CHEBI 34306
type: UnificationXref
id: CHEBI:34306
db: ChEBI

ChemicalStructure/PW C002163
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@]1(CCCCCCC)CCC[C@]1([H])CCCCCCCC

Arachidonate 15-lipoxygenase
type: Protein
cellular location: Cytoplasm
entity reference: Arachidonate 15-lipoxygenase

Leukotriene D4
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28666
xref: Reference/ChemSpider 4444401
xref: Reference/HMDB HMDB0003080
xref: Reference/CAS 73836-78-9
xref: Reference/KEGG Compound C05951
xref: Reference/PubChem-compound 5280878
chemical formula: C25H40N2O6S
molecular weight: 496.2607
structure: ChemicalStructure/PW C001775

20-Hydroxy-leukotriene B4
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 20-Hydroxy-leukotriene B4

Reference/HMDB HMDB0001043
type: UnificationXref
id: HMDB0001043
db: HMDB

Reference/CAS 506-32-1
type: UnificationXref
id: 506-32-1
db: CAS

Prostaglandin G2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin G2

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Compound/PW C006229 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-KETE
stoichiometric coefficient: 1.0

Reference/KEGG Compound C04230
type: UnificationXref
id: C04230
db: KEGG Compound

ChemicalStructure/PW C002389
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC[C@H](O)\C=C\C1OC1C\C=C/C\C=C/CCCC(O)=O

Reference/HMDB HMDB0003235
type: UnificationXref
id: HMDB0003235
db: HMDB

Glutathione peroxidase 1
type: ProteinReference
xref: Reference/UniProt P07203
organism: Homo sapiens

Compound/PW C002105 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 12(S)-HPETE
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 28099
type: UnificationXref
id: CHEBI:28099
db: ChEBI

Reference/CAS 73836-78-9
type: UnificationXref
id: 73836-78-9
db: CAS

Reference/ChemSpider 4444399
type: UnificationXref
id: 4444399
db: ChemSpider

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/BioCyc PROSTAGLANDIN-H2
type: UnificationXref
id: PROSTAGLANDIN-H2
db: BioCyc

Cytochrome P450 2U1
type: ProteinReference
xref: Reference/UniProt Q7Z449
organism: Homo sapiens

Thromboxane A2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Thromboxane A2

Reference/ChEBI CHEBI 34487
type: UnificationXref
id: CHEBI:34487
db: ChEBI

Cytochrome P450 2E1
type: ProteinReference
xref: Reference/UniProt P05181
organism: Homo sapiens

6-Keto-prostaglandin F1a
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 6-Keto-prostaglandin F1a

Reference/ChEBI CHEBI 34486
type: UnificationXref
id: CHEBI:34486
db: ChEBI

11,12-Epoxyeicosatrienoic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 11,12-Epoxyeicosatrienoic acid

19(S)-HETE
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 19(S)-HETE

Reference/SMPDB SMP0000084
type: UnificationXref
id: SMP0000084
db: SMPDB

Reference/HMDB HMDB0002710
type: UnificationXref
id: HMDB0002710
db: HMDB

Cytochrome P450 4F8
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Cytochrome P450 4F8

Thromboxane A2
type: SmallMoleculeReference
xref: Reference/CAS 57576-52-0
xref: Reference/PubChem-compound 5280497
xref: Reference/ChemSpider 4444137
xref: Reference/BioCyc ALPHA11-ALPHA-EPOXY-15-HYDROXYTHROMBA
xref: Reference/ChEBI CHEBI 15627
xref: Reference/KEGG Compound C02198
xref: Reference/HMDB HMDB0001452
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001121

Prostaglandin G/H synthase 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin G/H synthase 1

Reference/ChemSpider 4446324
type: UnificationXref
id: 4446324
db: ChemSpider

Reference/ChemSpider 4446326
type: UnificationXref
id: 4446326
db: ChemSpider

Reference/CAS 74581-83-2
type: UnificationXref
id: 74581-83-2
db: CAS

Reference/ChemSpider 4446323
type: UnificationXref
id: 4446323
db: ChemSpider

Cytochrome P450 2B6
type: ProteinReference
xref: Reference/UniProt P20813
organism: Homo sapiens

Reference/ChEBI CHEBI 34230
type: UnificationXref
id: CHEBI:34230
db: ChEBI

LysoPC(14:0/0:0)
type: SmallMolecule
cellular location: Cytoplasm
entity reference: LysoPC(14:0/0:0)

ChemicalStructure/PW C002644
type: ChemicalStructure
structure format: SMILES
structure data: O[C@@H](CCCC(O)=O)\C=C/C=C/C=C/[C@H](O)C\C=C/CCCCC(O)=O

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/PubChem-compound 5282411
type: UnificationXref
id: 5282411
db: PubChem-compound

Reference/PubChem-compound 3308
type: UnificationXref
id: 3308
db: PubChem-compound

Reference/ChEBI CHEBI 34229
type: UnificationXref
id: CHEBI:34229
db: ChEBI

Reference/ChemSpider 4444133
type: UnificationXref
id: 4444133
db: ChemSpider

Reference/ChemSpider 4444132
type: UnificationXref
id: 4444132
db: ChemSpider

Reference/ChemSpider 4444137
type: UnificationXref
id: 4444137
db: ChemSpider

Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Cytochrome P450 4F8
type: ProteinReference
xref: Reference/UniProt P98187
organism: Homo sapiens

5,6-DHET
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5283142
xref: Reference/ChemSpider 4446266
xref: Reference/KEGG Compound C14772
xref: Reference/ChEBI CHEBI 63974
xref: Reference/HMDB HMDB0002343
xref: Reference/CAS 213382-49-1
chemical formula: C20H34O4
molecular weight: 338.2457
structure: ChemicalStructure/PW C001579

Cytochrome P450 2J2
type: ProteinReference
xref: Reference/UniProt P51589
organism: Homo sapiens

ChemicalStructure/PW C003933
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCC(=O)OC[C@]([H])(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC

Cytochrome P450 2C8
type: ProteinReference
xref: Reference/UniProt P10632
organism: Homo sapiens

Reference/HMDB HMDB0001403
type: UnificationXref
id: HMDB0001403
db: HMDB

Compound/PW C001511 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 8,9-Epoxyeicosatrienoic acid
stoichiometric coefficient: 1.0

5.3.99.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001121 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Thromboxane A2
spontaneous: false
EC number: 5.3.99.5
left: Prostaglandin H2
name: Prostaglandin H2 → Thromboxane A2
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P35354
type: UnificationXref
id: P35354
db: UniProt

20-Hydroxy-leukotriene B4
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 20-Hydroxy-leukotriene B4

Leukotriene C4
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Leukotriene C4

Cytochrome P450 4A11
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 4A11

Compound/PW C000949 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin E2
stoichiometric coefficient: 1.0

Reference/BioCyc 5Z13E-15S-9-ALPHA11-ALPHA15-TRIHY
type: UnificationXref
id: 5Z13E-15S-9-ALPHA11-ALPHA15-TRIHY
db: BioCyc

8(S)-HPETE
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 8(S)-HPETE

Reference/HMDB HMDB0013633
type: UnificationXref
id: HMDB0013633
db: HMDB

Reference/CAS 41340-25-4
type: UnificationXref
id: 41340-25-4
db: CAS

Reference/PubChem-compound 5280493
type: UnificationXref
id: 5280493
db: PubChem-compound

Prostaglandin-H2 D-isomerase
type: ProteinReference
xref: Reference/UniProt P41222
organism: Homo sapiens

Reference/CAS 551-11-1
type: UnificationXref
id: 551-11-1
db: CAS

Reference/PubChem-compound 5280492
type: UnificationXref
id: 5280492
db: PubChem-compound

ChemicalStructure/PW C001529
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCC(O)C(O)C\C=C/C\C=C/C\C=C/CCCC(O)=O

Reference/ChEBI CHEBI 34450
type: UnificationXref
id: CHEBI:34450
db: ChEBI

Reference/BioCyc CPD-8892
type: UnificationXref
id: CPD-8892
db: BioCyc

ChemicalStructure/PW C002614
type: ChemicalStructure
structure format: SMILES
structure data: OCCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

2,3-Dinor-8iso prostaglandin F1α
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 2,3-Dinor-8iso prostaglandin F1α

ChemicalStructure/PW C001775
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5280497
type: UnificationXref
id: 5280497
db: PubChem-compound

Compound/PW C008524 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 12-KETE
stoichiometric coefficient: 1.0

Compound/PW C000080 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00909
type: UnificationXref
id: C00909
db: KEGG Compound

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Leukotriene A4
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Leukotriene A4

Reference/ChEBI CHEBI 16856
type: UnificationXref
id: CHEBI:16856
db: ChEBI

Reference/ChEBI CHEBI 64095
type: UnificationXref
id: CHEBI:64095
db: ChEBI

ChemicalStructure/PW C001579
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/CC(O)C(O)CCCC(O)=O

Reference/HMDB HMDB0010379
type: UnificationXref
id: HMDB0010379
db: HMDB

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Bifunctional epoxide hydrolase 2
type: Protein
cellular location: Cytoplasm
entity reference: Bifunctional epoxide hydrolase 2

Thromboxane-A synthase
type: ProteinReference
xref: Reference/UniProt P24557
organism: Homo sapiens

20-Hydroxy-leukotriene B4
type: SmallMoleculeReference
xref: Reference/ChemSpider 4444320
xref: Reference/ChEBI CHEBI 15646
xref: Reference/KEGG Compound C04853
xref: Reference/CAS 79516-82-8
xref: Reference/HMDB HMDB0001509
xref: Reference/PubChem-compound 5280745
xref: Reference/BioCyc 20-OH-LTB4
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001162

Reference/HMDB HMDB0002752
type: UnificationXref
id: HMDB0002752
db: HMDB

Reference/CAS 42935-17-1
type: UnificationXref
id: 42935-17-1
db: CAS

Compound/PW C002113 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 14,15-Epoxy-5,8,11-eicosatrienoic acid
stoichiometric coefficient: 1.0

Compound/PW C000949 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin E2
stoichiometric coefficient: 1.0

Prostaglandin G/H synthase 2
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin G/H synthase 2

Prostaglandin-c2
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Prostaglandin-c2

16(R)-HETE
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 16(R)-HETE

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: NADPH

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Glutathione
type: SmallMoleculeReference
xref: Reference/CAS 70-18-8
xref: Reference/HMDB HMDB0000125
xref: Reference/BioCyc OXIDIZED-GLUTATHIONE
xref: Reference/KEGG Compound C00051
xref: Reference/ChEBI CHEBI 16856
xref: Reference/PubChem-compound 124886
xref: Reference/ChemSpider 111188
chemical formula: C10H17N3O6S
molecular weight: 307.0838
structure: ChemicalStructure/PW C000080

11-Dehydro-thromboxane B2
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 11-Dehydro-thromboxane B2

Reference/ChemSpider 97008
type: UnificationXref
id: 97008
db: ChemSpider

Reference/ChEBI CHEBI 607727
type: UnificationXref
id: CHEBI:607727
db: ChEBI

Protein/914 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Prostaglandin G/H synthase 1
stoichiometric coefficient: 2.0

Cytochrome P450 2U1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 2U1

Reference/PubChem-compound 448457
type: UnificationXref
id: 448457
db: PubChem-compound

Leukotriene A-4 hydrolase
type: Protein
cellular location: Cytoplasm
entity reference: Leukotriene A-4 hydrolase

2,3-Dinor-8iso prostaglandin F2α
type: SmallMoleculeReference
xref: Reference/PubChem-compound 17395792
xref: Reference/ChemSpider 21467087
xref: Reference/ChEBI CHEBI 34230
xref: Reference/HMDB HMDB0061378
chemical formula: C18H30O5
molecular weight: 326.20932
structure: ChemicalStructure/PW C040708

ChemicalStructure/PW C001562
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/CC(O)C(O)C\C=C/C\C=C/CCCC(O)=O

2,3-Dinor-8iso prostaglandin F1α
type: SmallMoleculeReference
xref: Reference/PubChem-compound 17395793
xref: Reference/HMDB HMDB0061377
xref: Reference/ChEBI CHEBI 34229
chemical formula: C18H32O5
molecular weight: 328.22498
structure: ChemicalStructure/PW C040709

ChemicalStructure/PW C001561
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/CC(O)C(O)C\C=C/CCCC(O)=O

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Aldo-keto reductase family 1 member C3
type: Protein
cellular location: Cytoplasm
entity reference: Aldo-keto reductase family 1 member C3

Thromboxane A2
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Thromboxane A2

Compound/PW C006773 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-HETE
stoichiometric coefficient: 1.0

Compound/PW C002163 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 8-Isoprostane
stoichiometric coefficient: 1.0

Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 34490
type: UnificationXref
id: CHEBI:34490
db: ChEBI

Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin H2
stoichiometric coefficient: 1.0

Compound/PW C002170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11,12-Epoxyeicosatrienoic acid
stoichiometric coefficient: 1.0

Reference/CAS 79516-82-8
type: UnificationXref
id: 79516-82-8
db: CAS

Reference/HMDB HMDB0003876
type: UnificationXref
id: HMDB0003876
db: HMDB

Reference/HMDB HMDB0000125
type: UnificationXref
id: HMDB0000125
db: HMDB

Arachidonic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Arachidonic acid

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

15(S)-HPETE
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 15(S)-HPETE

Reference/ChemSpider 4510033
type: UnificationXref
id: 4510033
db: ChemSpider

Reference/HMDB HMDB0001452
type: UnificationXref
id: HMDB0001452
db: HMDB

Reference/CAS 70-18-8
type: UnificationXref
id: 70-18-8
db: CAS

Reference/ChemSpider 4444314
type: UnificationXref
id: 4444314
db: ChemSpider

Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

Compound/PW C001579 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5,6-DHET
stoichiometric coefficient: 1.0

Reference/CAS 81276-03-1
type: UnificationXref
id: 81276-03-1
db: CAS

Reference/PubChem-compound 5280884
type: UnificationXref
id: 5280884
db: PubChem-compound

Reference/ChEBI CHEBI 27555
type: UnificationXref
id: CHEBI:27555
db: ChEBI

14,15-DiHETrE
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 14,15-DiHETrE

Reference/PubChem-compound 5280885
type: UnificationXref
id: 5280885
db: PubChem-compound

Reference/PubChem-compound 5280882
type: UnificationXref
id: 5280882
db: PubChem-compound

Reference/PubChem-compound 5280883
type: UnificationXref
id: 5280883
db: PubChem-compound

Reference/BioCyc 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O
type: UnificationXref
id: 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O
db: BioCyc

Reference/PubChem-compound 5280880
type: UnificationXref
id: 5280880
db: PubChem-compound

Compound/PW C006773 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-HETE
stoichiometric coefficient: 1.0

Reference/ChemSpider 392692
type: UnificationXref
id: 392692
db: ChemSpider

1.14.99.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: Prostaglandin H2
spontaneous: false
EC number: 1.14.99.1
left: Prostaglandin G2
name: Prostaglandin G2 → Prostaglandin H2 + Water
conversion direction: LEFT_TO_RIGHT

Interaction13
type: MolecularInteraction
interaction type: direct_interaction
name: Etodolac inhibits Prostaglandin G/H synthase 2
participant: Prostaglandin G/H synthase 2
participant: Etodolac

Reference/PubChem-compound 5280888
type: UnificationXref
id: 5280888
db: PubChem-compound

Reference/PubChem-compound 5280889
type: UnificationXref
id: 5280889
db: PubChem-compound

Reference/PubChem-compound 11954043
type: UnificationXref
id: 11954043
db: PubChem-compound

Prostaglandin E synthase
type: ProteinReference
xref: Reference/UniProt O14684
organism: Homo sapiens

Reference/PubChem-compound 11954042
type: UnificationXref
id: 11954042
db: PubChem-compound

Glutathione peroxidase 1
type: Protein
cellular location: Cytoplasm
entity reference: Glutathione peroxidase 1

Carbonyl reductase [NADPH] 1
type: ProteinReference
xref: Reference/UniProt P16152
organism: Homo sapiens

Compound/PW C040708 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2,3-Dinor-8iso prostaglandin F2α
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000853
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/PubChem-compound 5280876
type: UnificationXref
id: 5280876
db: PubChem-compound

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Water

12(R)-HPETE
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 12(R)-HPETE

Reference/PubChem-compound 5280877
type: UnificationXref
id: 5280877
db: PubChem-compound

Reference/PubChem-compound 5280878
type: UnificationXref
id: 5280878
db: PubChem-compound

Reference/ChemSpider 4444307
type: UnificationXref
id: 4444307
db: ChemSpider

Thromboxane-A synthase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Thromboxane-A synthase

Reference/PubChem-compound 5288144
type: UnificationXref
id: 5288144
db: PubChem-compound

Reference/CAS 70981-96-3
type: UnificationXref
id: 70981-96-3
db: CAS

ChemicalStructure/PW C000821
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

Reference/KEGG Compound C13809
type: UnificationXref
id: C13809
db: KEGG Compound

Cytosolic phospholipase A2 beta
type: ProteinReference
xref: Reference/UniProt P0C869
organism: Homo sapiens

8,9-DiHETrE
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 8,9-DiHETrE

Compound/PW C003933 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: PC(14:0/20:4(5Z,8Z,11Z,14Z))
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

15(S)-HPETE
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 15(S)-HPETE

Reaction377
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002105 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000821 Cytoplasm/Stoichiometry/1.0
right: 12(S)-HPETE
spontaneous: false
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + Oxygen → 12(S)-HPETE
conversion direction: LEFT_TO_RIGHT

Reaction378
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002106 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000821 Cytoplasm/Stoichiometry/1.0
right: 15(S)-HPETE
spontaneous: false
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + Oxygen → 15(S)-HPETE
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

3.3.2.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000853 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001030 Cytoplasm/Stoichiometry/1.0
right: Leukotriene B4
spontaneous: false
EC number: 3.3.2.6
left: Water
left: Leukotriene A4
name: Leukotriene A4 + Water → Leukotriene B4
conversion direction: LEFT_TO_RIGHT

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/ChEBI CHEBI 15553
type: UnificationXref
id: CHEBI:15553
db: ChEBI

Reference/ChEBI CHEBI 15552
type: UnificationXref
id: CHEBI:15552
db: ChEBI

Reference/ChEBI CHEBI 15555
type: UnificationXref
id: CHEBI:15555
db: ChEBI

Reference/ChEBI CHEBI 15554
type: UnificationXref
id: CHEBI:15554
db: ChEBI

Compound/PW C000143 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15558
type: UnificationXref
id: CHEBI:15558
db: ChEBI

Prostacyclin synthase
type: ProteinReference
xref: Reference/UniProt Q16647
organism: Homo sapiens

Reference/ChEBI CHEBI 15551
type: UnificationXref
id: CHEBI:15551
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/PubChem-compound 5280893
type: UnificationXref
id: 5280893
db: PubChem-compound

5-HETE
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5-HETE

ChemicalStructure/PW C006388
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCC(=O)OC[C@@H](O)COP([O-])(=O)OCC[N+](C)(C)C

Reference/PubChem-compound 5280892
type: UnificationXref
id: 5280892
db: PubChem-compound

4.4.1.20
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001030 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000933 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Leukotriene C4
spontaneous: false
EC number: 4.4.1.20
left: Leukotriene A4
left: Glutathione
name: Glutathione + Leukotriene A4 → Leukotriene C4
conversion direction: LEFT_TO_RIGHT

Reaction385
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002183 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000821 Cytoplasm/Stoichiometry/1.0
right: 8(S)-HPETE
spontaneous: false
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + Oxygen → 8(S)-HPETE
conversion direction: LEFT_TO_RIGHT

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

ReactionCatalysis476
type: Catalysis
controller: Epoxide hydratase 2
controlled: Reaction325
control type: ACTIVATION

ReactionCatalysis477
type: Catalysis
controller: Cytochrome P450 2B6
controlled: 1.14.13.-
control type: ACTIVATION

ReactionCatalysis474
type: Catalysis
controller: Cytochrome P450 2C8
controlled: 1.14.14.1
control type: ACTIVATION

Reference/UniProt P10632
type: UnificationXref
id: P10632
db: UniProt

ReactionCatalysis475
type: Catalysis
controller: Cytochrome P450 2B6
controlled: 1.14.13.-
control type: ACTIVATION

ReactionCatalysis473
type: Catalysis
controller: Cytochrome P450 2C8
controlled: 1.14.14.1
control type: ACTIVATION

ReactionCatalysis470
type: Catalysis
controller: Cytochrome P450 2C8
controlled: 1.14.14.1
control type: ACTIVATION

ReactionCatalysis471
type: Catalysis
controller: Cytochrome P450 2C8
controlled: 1.14.14.1
control type: ACTIVATION

Compound/PW C001065 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/CAS 192461-96-4
type: UnificationXref
id: 192461-96-4
db: CAS

ChemicalStructure/PW C000889
type: ChemicalStructure
structure format: SMILES

12-Keto-leukotriene B4
type: SmallMoleculeReference
xref: Reference/ChemSpider 4444399
xref: Reference/PubChem-compound 5280876
xref: Reference/CAS 136696-10-1
xref: Reference/KEGG Compound C05949
xref: Reference/ChEBI CHEBI 27814
xref: Reference/HMDB HMDB0004234
chemical formula: C20H30O4
molecular weight: 334.21442
structure: ChemicalStructure/PW C002098

Prostaglandin B2
type: SmallMoleculeReference
xref: Reference/ChemSpider 4450370
xref: Reference/HMDB HMDB0004236
xref: Reference/PubChem-compound 5288144
xref: Reference/KEGG Compound C05954
xref: Reference/ChEBI CHEBI 28099
xref: Reference/CAS 13367-85-6
chemical formula: C20H30O4
molecular weight: 334.21442
structure: ChemicalStructure/PW C002099

Reference/ChEBI CHEBI 28209
type: UnificationXref
id: CHEBI:28209
db: ChEBI

Reference/CAS 51982-36-6
type: UnificationXref
id: 51982-36-6
db: CAS

ReactionCatalysis469
type: Catalysis
controller: Cytochrome P450 2C8
controlled: 1.14.14.1
control type: ACTIVATION

ChemicalStructure/PW C009220
type: ChemicalStructure
structure format: SMILES
structure data: CCC1=C2NC3=C(CCOC3(CC)CC(O)=O)C2=CC=C1

Reference/UniProt P19440
type: UnificationXref
id: P19440
db: UniProt

Reference/ChEBI CHEBI 27595
type: UnificationXref
id: CHEBI:27595
db: ChEBI

ReactionCatalysis467
type: Catalysis
controller: Carbonyl reductase [NADPH] 1
controlled: Reaction885
control type: ACTIVATION

ReactionCatalysis468
type: Catalysis
controller: Arachidonate 15-lipoxygenase
controlled: Reaction378
control type: ACTIVATION

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

ReactionCatalysis465
type: Catalysis
controller: Glutathione peroxidase 1
controlled: 1.11.1.9
control type: ACTIVATION

ReactionCatalysis466
type: Catalysis
controller: Aldo-keto reductase family 1 member C3
controlled: Reaction884
control type: ACTIVATION

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

ReactionCatalysis463
type: Catalysis
controller: Leukotriene C4 synthase
controlled: 4.4.1.20
control type: ACTIVATION

Reference/CAS 70608-72-9
type: UnificationXref
id: 70608-72-9
db: CAS

ReactionCatalysis464
type: Catalysis
controller: Gamma-glutamyltranspeptidase 1
controlled: Reaction874
control type: ACTIVATION

ReactionCatalysis461
type: Catalysis
controller: Leukotriene-B(4) omega-hydroxylase 1
controlled: Reaction872
control type: ACTIVATION

ReactionCatalysis462
type: Catalysis
controller: Leukotriene A-4 hydrolase
controlled: 3.3.2.6
control type: ACTIVATION

Reaction326
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001511 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001561 Cytoplasm/Stoichiometry/1.0
right: 8,9-DiHETrE
spontaneous: false
left: Water
left: 8,9-Epoxyeicosatrienoic acid
name: 8,9-Epoxyeicosatrienoic acid + Water → 8,9-DiHETrE
conversion direction: LEFT_TO_RIGHT

Reaction327
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001579 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001477 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
right: 5,6-DHET
spontaneous: false
left: Water
left: 5,6-Epoxy-8,11,14-eicosatrienoic acid
name: 5,6-Epoxy-8,11,14-eicosatrienoic acid + Water → 5,6-DHET
conversion direction: LEFT_TO_RIGHT

Epoxide hydratase 2
type: Complex
component stoichiometry: Protein/1609 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Bifunctional epoxide hydrolase 2

ChemicalStructure/PW C001986
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O

ChemicalStructure/PW C001511
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/CC1OC1C\C=C/CCCC(O)=O

5-KETE
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 52449
xref: Reference/HMDB HMDB0010217
xref: Reference/ChemSpider 4446283
xref: Reference/PubChem-compound 5283159
xref: Reference/KEGG Compound C14732
xref: Reference/CAS 126432-17-5
chemical formula: C20H30O3
molecular weight: 318.21948
structure: ChemicalStructure/PW C006229

Reference/KEGG Compound C05356
type: UnificationXref
id: C05356
db: KEGG Compound

Reaction325
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001529 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002113 Cytoplasm/Stoichiometry/1.0
right: 14,15-DiHETrE
spontaneous: false
left: 14,15-Epoxy-5,8,11-eicosatrienoic acid
left: Water
name: 14,15-Epoxy-5,8,11-eicosatrienoic acid + Water → 14,15-DiHETrE
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 111188
type: UnificationXref
id: 111188
db: ChemSpider

ReactionCatalysis498
type: Catalysis
controller: Cytosolic phospholipase A2 beta
controlled: 3.1.1.4
control type: ACTIVATION

Reference/CAS 80434-82-8
type: UnificationXref
id: 80434-82-8
db: CAS

ReactionCatalysis496
type: Catalysis
controller: Cytochrome P450 4F8
controlled: 1.14.15.3
control type: ACTIVATION

Reference/ChemSpider 30776537
type: UnificationXref
id: 30776537
db: ChemSpider

ReactionCatalysis497
type: Catalysis
controller: Cytochrome P450 2U1
controlled: 1.14.15.3
control type: ACTIVATION

Reference/CAS 72025-60-6
type: UnificationXref
id: 72025-60-6
db: CAS

ReactionCatalysis494
type: Catalysis
controller: Cytochrome P450 2U1
controlled: Reaction906
control type: ACTIVATION

Reference/CAS 27025-41-8
type: UnificationXref
id: 27025-41-8
db: CAS

ReactionCatalysis495
type: Catalysis
controller: Cytochrome P450 4A11
controlled: 1.14.15.3
control type: ACTIVATION

ReactionCatalysis492
type: Catalysis
controller: Arachidonate 12-lipoxygenase, 12R-type
controlled: 1.13.11.-
control type: ACTIVATION

ReactionCatalysis493
type: Catalysis
controller: Cytochrome P450 2J2
controlled: Reaction906
control type: ACTIVATION

ReactionCatalysis490
type: Catalysis
controller: Cytochrome P450 2E1
controlled: Reaction906
control type: ACTIVATION

Compound/PW C040709 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2,3-Dinor-8iso prostaglandin F1α
stoichiometric coefficient: 1.0

ReactionCatalysis491
type: Catalysis
controller: Arachidonate 12-lipoxygenase, 12S-type
controlled: Reaction377
control type: ACTIVATION

Compound/PW C001820 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thromboxane B2
stoichiometric coefficient: 1.0

Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 28666
type: UnificationXref
id: CHEBI:28666
db: ChEBI

Reference/ChEBI CHEBI 28667
type: UnificationXref
id: CHEBI:28667
db: ChEBI

Reference/HMDB HMDB0006059
type: UnificationXref
id: HMDB0006059
db: HMDB

ReactionCatalysis489
type: Catalysis
controller: Arachidonate 15-lipoxygenase B
controlled: Reaction385
control type: ACTIVATION

ReactionCatalysis487
type: Catalysis
controller: Epoxide hydratase 2
controlled: Reaction327
control type: ACTIVATION

ReactionCatalysis485
type: Catalysis
controller: Epoxide hydratase 2
controlled: Reaction326
control type: ACTIVATION

ReactionCatalysis486
type: Catalysis
controller: Cytochrome P450 2B6
controlled: 1.14.13.-
control type: ACTIVATION

ReactionCatalysis484
type: Catalysis
controller: Cytochrome P450 2B6
controlled: 1.14.13.-
control type: ACTIVATION

Reference/ChemSpider 4444320
type: UnificationXref
id: 4444320
db: ChemSpider

ReactionCatalysis481
type: Catalysis
controller: Glutathione peroxidase 1
controlled: 1.11.1.9
control type: ACTIVATION

ReactionCatalysis482
type: Catalysis
controller: Prostaglandin G/H synthase 2
controlled: 1.14.99.1
control type: ACTIVATION

ReactionCatalysis480
type: Catalysis
controller: Arachidonate 5-lipoxygenase
controlled: 1.13.11.34
control type: ACTIVATION

ChemicalStructure/PW C001726
type: ChemicalStructure
structure format: SMILES

Prostaglandin G/H synthase 1
type: Complex
component stoichiometry: Protein/914 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
cellular location: Endoplasmic Reticulum Membrane
component: Prostaglandin G/H synthase 1

Reference/ChEBI CHEBI 27562
type: UnificationXref
id: CHEBI:27562
db: ChEBI

ReactionCatalysis478
type: Catalysis
controller: Epoxide hydratase 2
controlled: Reaction899
control type: ACTIVATION

ReactionCatalysis479
type: Catalysis
controller: Arachidonate 5-lipoxygenase
controlled: 1.13.11.34
control type: ACTIVATION

Reference/CAS 57576-52-0
type: UnificationXref
id: 57576-52-0
db: CAS

Reference/UniProt P09960
type: UnificationXref
id: P09960
db: UniProt

Reference/ChEBI CHEBI 4909
type: UnificationXref
id: CHEBI:4909
db: ChEBI

Reference/PubChem-compound 5283078
type: UnificationXref
id: 5283078
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 53477781
type: UnificationXref
id: 53477781
db: PubChem-compound

Prostaglandin E2
type: SmallMoleculeReference
xref: Reference/CAS 363-24-6
xref: Reference/ChemSpider 4444059
xref: Reference/KEGG Compound C00584
xref: Reference/BioCyc 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
xref: Reference/PubChem-compound 5280360
xref: Reference/ChEBI CHEBI 15551
xref: Reference/HMDB HMDB0001220
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C000949

direct_interaction
type: InteractionVocabulary

12(S)-HPETE
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 12(S)-HPETE

Reference/UniProt P41222
type: UnificationXref
id: P41222
db: UniProt

Reference/HMDB HMDB0004699
type: UnificationXref
id: HMDB0004699
db: HMDB

Reference/KEGG Compound C14717
type: UnificationXref
id: C14717
db: KEGG Compound

Reference/UniProt P0C869
type: UnificationXref
id: P0C869
db: UniProt

Reference/HMDB HMDB0004693
type: UnificationXref
id: HMDB0004693
db: HMDB

Reference/HMDB HMDB0004692
type: UnificationXref
id: HMDB0004692
db: HMDB

Reference/PubChem-compound 5353269
type: UnificationXref
id: 5353269
db: PubChem-compound

Reference/HMDB HMDB0004694
type: UnificationXref
id: HMDB0004694
db: HMDB

Protein/752 Endoplasmic Reticulum Membrane/Stoichiometry/3.0
type: Stoichiometry
physical entity: Leukotriene C4 synthase
stoichiometric coefficient: 3.0

Compound/PW C002389 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 15H-11,12-EETA
stoichiometric coefficient: 1.0

Reference/UniProt Q02928
type: UnificationXref
id: Q02928
db: UniProt

Reference/CAS 71160-24-2
type: UnificationXref
id: 71160-24-2
db: CAS

Reference/UniProt P34913
type: UnificationXref
id: P34913
db: UniProt

Prostaglandin G/H synthase 2
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Prostaglandin G/H synthase 2

Compound/PW C040450 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5,6-Epoxytetraene
stoichiometric coefficient: 1.0

Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001198
type: UnificationXref
id: HMDB0001198
db: HMDB

Reference/UniProt Q7Z449
type: UnificationXref
id: Q7Z449
db: UniProt

Reference/CAS 67910-12-7
type: UnificationXref
id: 67910-12-7
db: CAS

Compound/PW C001687 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin J2
stoichiometric coefficient: 1.0

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Prostaglandin D2
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Prostaglandin D2

Reference/CAS 192461-95-3
type: UnificationXref
id: 192461-95-3
db: CAS

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/HMDB HMDB0004238
type: UnificationXref
id: HMDB0004238
db: HMDB

Reference/ChemSpider 950
type: UnificationXref
id: 950
db: ChemSpider

Reference/ChemSpider 4450370
type: UnificationXref
id: 4450370
db: ChemSpider

Reference/HMDB HMDB0004236
type: UnificationXref
id: HMDB0004236
db: HMDB

Reference/HMDB HMDB0004234
type: UnificationXref
id: HMDB0004234
db: HMDB

Reference/KEGG Compound C14732
type: UnificationXref
id: C14732
db: KEGG Compound

Leukotriene-B(4) omega-hydroxylase 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Leukotriene-B(4) omega-hydroxylase 1

Leukotriene D4
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Leukotriene D4

Leukotriene C4
type: SmallMoleculeReference
xref: Reference/ChemSpider 4444133
xref: Reference/CAS 72025-60-6
xref: Reference/ChEBI CHEBI 16978
xref: Reference/BioCyc LEUKOTRIENE-C4
xref: Reference/PubChem-compound 5280493
xref: Reference/KEGG Compound C02166
xref: Reference/HMDB HMDB0001198
chemical formula: C30H47N3O9S
molecular weight: 625.3033
structure: ChemicalStructure/PW C000933

11,14,15-THETA
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 11,14,15-THETA

Reference/KEGG Compound C00584
type: UnificationXref
id: C00584
db: KEGG Compound

Compound/PW C002099 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin B2
stoichiometric coefficient: 1.0

Reference/UniProt Q08477
type: UnificationXref
id: Q08477
db: UniProt

Reference/UniProt O14684
type: UnificationXref
id: O14684
db: UniProt

Reference/CAS 363-24-6
type: UnificationXref
id: 363-24-6
db: CAS

Reference/KEGG Compound C14749
type: UnificationXref
id: C14749
db: KEGG Compound

Reference/KEGG Compound C14748
type: UnificationXref
id: C14748
db: KEGG Compound

Compound/PW C002098 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 12-Keto-leukotriene B4
stoichiometric coefficient: 1.0

11H-14,15-EETA
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 11H-14,15-EETA

Reference/HMDB HMDB0004242
type: UnificationXref
id: HMDB0004242
db: HMDB

Reference/HMDB HMDB0004241
type: UnificationXref
id: HMDB0004241
db: HMDB

Compound/PW C001121 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thromboxane A2
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0004244
type: UnificationXref
id: HMDB0004244
db: HMDB

Reference/ChEBI CHEBI 27485
type: UnificationXref
id: CHEBI:27485
db: ChEBI

Compound/PW C002106 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 15(S)-HPETE
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0004243
type: UnificationXref
id: HMDB0004243
db: HMDB

Compound/PW C001561 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 8,9-DiHETrE
stoichiometric coefficient: 1.0

Compound/PW C006776 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11-Epi-PGF2a
stoichiometric coefficient: 1.0

Reference/BioCyc PHOSPHATIDYLCHOLINE
type: UnificationXref
id: PHOSPHATIDYLCHOLINE
db: BioCyc

Reference/KEGG Compound C00127
type: UnificationXref
id: C00127
db: KEGG Compound

Reference/KEGG Compound C14770
type: UnificationXref
id: C14770
db: KEGG Compound

Reference/CAS 136696-10-1
type: UnificationXref
id: 136696-10-1
db: CAS

11,12-DiHETrE
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 11,12-DiHETrE

Compound/PW C002614 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 20-Hydroxyeicosatetraenoic acid
stoichiometric coefficient: 1.0

Oxidized glutathione
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003337
xref: Reference/PubChem-compound 5255796
xref: Reference/ChemSpider 950
xref: Reference/KEGG Compound C00127
xref: Reference/BioCyc OXIDIZED-GLUTATHIONE
xref: Reference/CAS 27025-41-8
xref: Reference/ChEBI CHEBI 17858
chemical formula: C20H32N6O12S2
molecular weight: 612.152
structure: ChemicalStructure/PW C001847

ChemicalStructure/PW C000933
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 28158
type: UnificationXref
id: CHEBI:28158
db: ChEBI

Reference/KEGG Compound C14769
type: UnificationXref
id: C14769
db: KEGG Compound

Reference/KEGG Compound C14768
type: UnificationXref
id: C14768
db: KEGG Compound

Reference/HMDB HMDB0004264
type: UnificationXref
id: HMDB0004264
db: HMDB

ReactionCatalysis738
type: Catalysis
controller: Prostaglandin G/H synthase 2
controlled: 1.14.99.1
control type: ACTIVATION

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Oxygen

Reference/CAS 79551-85-2
type: UnificationXref
id: 79551-85-2
db: CAS

Reference/KEGG Compound C14781
type: UnificationXref
id: C14781
db: KEGG Compound

Gamma-glutamyltranspeptidase 1
type: Protein
cellular location: Cytoplasm
entity reference: Gamma-glutamyltranspeptidase 1

5-HPETE
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5-HPETE

11,12,15-THETA
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 11,12,15-THETA

Reference/PubChem-compound 444899
type: UnificationXref
id: 444899
db: PubChem-compound

Prostaglandin G2
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003235
xref: Reference/PubChem-compound 5280883
xref: Reference/ChEBI CHEBI 27647
xref: Reference/CAS 51982-36-6
xref: Reference/KEGG Compound C05956
xref: Reference/ChemSpider 4444406
chemical formula: C20H32O6
molecular weight: 368.21988
structure: ChemicalStructure/PW C001814

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

ChemicalStructure/PW C002098
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/CC(=O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O

ChemicalStructure/PW C002099
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC[C@@H](O)\C=C\C1=C(C\C=C/CCCC(O)=O)C(=O)CC1

Reference/ChEBI CHEBI 52449
type: UnificationXref
id: CHEBI:52449
db: ChEBI

Cytochrome P450 2J2
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 2J2

Reference/KEGG Compound C14774
type: UnificationXref
id: C14774
db: KEGG Compound

Reference/KEGG Compound C14773
type: UnificationXref
id: C14773
db: KEGG Compound

Reference/KEGG Compound C14772
type: UnificationXref
id: C14772
db: KEGG Compound

Reference/KEGG Compound C14771
type: UnificationXref
id: C14771
db: KEGG Compound

Compound/PW C001847 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxidized glutathione
stoichiometric coefficient: 1.0

Reference/KEGG Compound C14778
type: UnificationXref
id: C14778
db: KEGG Compound

Reference/ChemSpider 21467087
type: UnificationXref
id: 21467087
db: ChemSpider

Reference/KEGG Compound C14777
type: UnificationXref
id: C14777
db: KEGG Compound

Reference/KEGG Compound C14776
type: UnificationXref
id: C14776
db: KEGG Compound

Reference/KEGG Compound C14775
type: UnificationXref
id: C14775
db: KEGG Compound

Reference/UniProt P98187
type: UnificationXref
id: P98187
db: UniProt

Reference/ChemSpider 392800
type: UnificationXref
id: 392800
db: ChemSpider

Thromboxane B2
type: SmallMoleculeReference
xref: Reference/CAS 54397-85-2
xref: Reference/ChemSpider 4446261
xref: Reference/HMDB HMDB0003252
xref: Reference/ChEBI CHEBI 28728
xref: Reference/PubChem-compound 5283137
xref: Reference/KEGG Compound C05963
chemical formula: C20H34O6
molecular weight: 370.23553
structure: ChemicalStructure/PW C001820

Reference/KEGG Compound C04742
type: UnificationXref
id: C04742
db: KEGG Compound

ChemicalStructure/PW C006229
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/C=C/C(=O)CCCC(O)=O

Reference/ChEBI CHEBI 28130
type: UnificationXref
id: CHEBI:28130
db: ChEBI

Reference/KEGG Compound C14782
type: UnificationXref
id: C14782
db: KEGG Compound

Reaction915
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040452 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002105 Endoplasmic Reticulum/Stoichiometry/1.0
right: 12(S)-HETE
spontaneous: true
left: 12(S)-HPETE
name: 12(S)-HPETE → 12(S)-HETE
conversion direction: LEFT_TO_RIGHT

3.1.1.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C003933 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006388 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000821 Cytoplasm/Stoichiometry/1.0
right: LysoPC(14:0/0:0)
right: Arachidonic acid
spontaneous: false
EC number: 3.1.1.4
left: PC(14:0/20:4(5Z,8Z,11Z,14Z))
left: Water
name: PC(14:0/20:4(5Z,8Z,11Z,14Z)) + Water ↔ Arachidonic acid + LysoPC(14:0/0:0)
conversion direction: REVERSIBLE

1.14.15.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002614 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002614 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 20-Hydroxyeicosatetraenoic acid
spontaneous: false
EC number: 1.14.15.3
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + Oxygen → 20-Hydroxyeicosatetraenoic acid + Water
conversion direction: LEFT_TO_RIGHT

Reaction914
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002105 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008524 Endoplasmic Reticulum/Stoichiometry/1.0
right: 12-KETE
spontaneous: true
left: 12(S)-HPETE
name: 12(S)-HPETE → 12-KETE
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc OXIDIZED-GLUTATHIONE
type: UnificationXref
id: OXIDIZED-GLUTATHIONE
db: BioCyc

Reaction911
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040709 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002163 Endoplasmic Reticulum/Stoichiometry/1.0
right: 2,3-Dinor-8iso prostaglandin F1α
spontaneous: true
left: 8-Isoprostane
name: 8-Isoprostane → 2,3-Dinor-8iso prostaglandin F1α
conversion direction: LEFT_TO_RIGHT

Compound/PW C006775 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 19(S)-HETE
stoichiometric coefficient: 1.0

Reaction912
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040708 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002163 Endoplasmic Reticulum/Stoichiometry/1.0
right: 2,3-Dinor-8iso prostaglandin F2α
spontaneous: true
left: 8-Isoprostane
name: 8-Isoprostane → 2,3-Dinor-8iso prostaglandin F2α
conversion direction: LEFT_TO_RIGHT

Reaction910
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002163 Endoplasmic Reticulum/Stoichiometry/1.0
right: 8-Isoprostane
spontaneous: true
left: Arachidonic acid
name: Arachidonic acid → 8-Isoprostane
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 4446295
type: UnificationXref
id: 4446295
db: ChemSpider

Reference/KEGG Compound C00157
type: UnificationXref
id: C00157
db: KEGG Compound

Reference/CAS 67786-53-2
type: UnificationXref
id: 67786-53-2
db: CAS

Reference/ChemSpider 4446283
type: UnificationXref
id: 4446283
db: ChemSpider

Reference/ChemSpider 4446286
type: UnificationXref
id: 4446286
db: ChemSpider

Reference/ChemSpider 4446280
type: UnificationXref
id: 4446280
db: ChemSpider

Reference/ChemSpider 4446281
type: UnificationXref
id: 4446281
db: ChemSpider

Reference/PubChem-compound 5311211
type: UnificationXref
id: 5311211
db: PubChem-compound

Protein/773 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glutathione peroxidase 1
stoichiometric coefficient: 4.0

Bifunctional epoxide hydrolase 2
type: ProteinReference
xref: Reference/UniProt P34913
organism: Homo sapiens

Reference/CAS 87893-55-8
type: UnificationXref
id: 87893-55-8
db: CAS

Reference/ChemSpider 4446278
type: UnificationXref
id: 4446278
db: ChemSpider

Reference/ChemSpider 4446279
type: UnificationXref
id: 4446279
db: ChemSpider

Compound/PW C001084 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin D2
stoichiometric coefficient: 1.0

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/CAS 13367-85-6
type: UnificationXref
id: 13367-85-6
db: CAS

Reference/ChemSpider 4446270
type: UnificationXref
id: 4446270
db: ChemSpider

Reference/CAS 126432-17-5
type: UnificationXref
id: 126432-17-5
db: CAS

Reference/ChemSpider 4446271
type: UnificationXref
id: 4446271
db: ChemSpider

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

ChemicalStructure/PW C001121
type: ChemicalStructure
structure format: SMILES

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Prostaglandin B2
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Prostaglandin B2

Prostaglandin D2
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Prostaglandin D2

Reference/ChemSpider 4446266
type: UnificationXref
id: 4446266
db: ChemSpider

Reference/ChemSpider 4446268
type: UnificationXref
id: 4446268
db: ChemSpider

Reference/ChemSpider 4446261
type: UnificationXref
id: 4446261
db: ChemSpider

Compound/PW C001162 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 20-Hydroxy-leukotriene B4
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Gamma-glutamyltranspeptidase 1
type: ProteinReference
xref: Reference/UniProt P19440
organism: Homo sapiens

Reference/BioCyc 5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
type: UnificationXref
id: 5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
db: BioCyc

Reference/HMDB HMDB0001139
type: UnificationXref
id: HMDB0001139
db: HMDB

Prostaglandin H2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin H2

Reference/UniProt P09917
type: UnificationXref
id: P09917
db: UniProt

Leukotriene B4
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Leukotriene B4

8-HETE
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 8-HETE

Compound/PW C001726 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-Keto-prostaglandin F1a
stoichiometric coefficient: 1.0

12(R)-HETE
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 12(R)-HETE

ChemicalStructure/PW C040709
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040708
type: ChemicalStructure
structure format: SMILES

20-Hydroxyeicosatetraenoic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 20-Hydroxyeicosatetraenoic acid

Reference/HMDB HMDB0004659
type: UnificationXref
id: HMDB0004659
db: HMDB

Reference/BioCyc 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
type: UnificationXref
id: 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS
db: BioCyc

Reference/HMDB HMDB0001381
type: UnificationXref
id: HMDB0001381
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Glutathione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glutathione

Reference/HMDB HMDB0002232
type: UnificationXref
id: HMDB0002232
db: HMDB

8,9-Epoxyeicosatrienoic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 8,9-Epoxyeicosatrienoic acid

Reference/ChEBI CHEBI 64489
type: UnificationXref
id: CHEBI:64489
db: ChEBI

12(S)-HETE
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 12(S)-HETE

Reference/ChemSpider 7827808
type: UnificationXref
id: 7827808
db: ChemSpider

Reference/ChemSpider 7827807
type: UnificationXref
id: 7827807
db: ChemSpider

Reference/ChemSpider 7827806
type: UnificationXref
id: 7827806
db: ChemSpider

Prostaglandin J2
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002710
xref: Reference/PubChem-compound 5280884
xref: Reference/KEGG Compound C05957
xref: Reference/ChemSpider 4444407
xref: Reference/CAS 60203-57-8
xref: Reference/ChEBI CHEBI 27485
chemical formula: C20H30O4
molecular weight: 334.21442
structure: ChemicalStructure/PW C001687

Reference/HMDB HMDB0003337
type: UnificationXref
id: HMDB0003337
db: HMDB

Reference/HMDB HMDB0005998
type: UnificationXref
id: HMDB0005998
db: HMDB

Reference/ChemSpider 395250
type: UnificationXref
id: 395250
db: ChemSpider

Reference/KEGG Compound C06991
type: UnificationXref
id: C06991
db: KEGG Compound

Etodolac Action Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/627
pathway order: PathwayEnzymeReaction/629
pathway order: PathwayEnzymeReaction/628
pathway order: PathwayEnzymeReaction/623
pathway order: PathwayEnzymeReaction/622
pathway order: PathwayEnzymeReaction/666
pathway order: PathwayInteraction/13
pathway order: PathwayEnzymeReaction/625
pathway order: PathwayEnzymeReaction/669
pathway order: PathwayEnzymeReaction/624
pathway order: PathwayEnzymeReaction/668
pathway order: PathwayEnzymeReaction/663
pathway order: PathwayEnzymeReaction/621
pathway order: PathwayEnzymeReaction/620
pathway order: PathwayEnzymeReaction/661
pathway order: PathwayEnzymeReaction/619
pathway order: PathwayEnzymeReaction/638
pathway order: PathwayEnzymeReaction/637
pathway order: PathwayEnzymeReaction/639
pathway order: PathwayEnzymeReaction/634
pathway order: PathwayEnzymeReaction/678
pathway order: PathwayEnzymeReaction/633
pathway order: PathwayEnzymeReaction/677
pathway order: PathwayEnzymeReaction/636
pathway order: PathwayEnzymeReaction/635
pathway order: PathwayEnzymeReaction/630
pathway order: PathwayEnzymeReaction/674
pathway order: PathwayEnzymeReaction/599
pathway order: PathwayEnzymeReaction/632
pathway order: PathwayEnzymeReaction/676
pathway order: PathwayEnzymeReaction/598
pathway order: PathwayEnzymeReaction/631
pathway order: PathwayEnzymeReaction/675
pathway order: PathwayEnzymeReaction/670
pathway order: PathwayEnzymeReaction/672
pathway order: PathwayEnzymeReaction/671
pathway order: PathwayEnzymeReaction/605
pathway order: PathwayEnzymeReaction/604
pathway order: PathwayEnzymeReaction/607
pathway order: PathwayEnzymeReaction/211552
pathway order: PathwayEnzymeReaction/606
pathway order: PathwayEnzymeReaction/601
pathway order: PathwayEnzymeReaction/600
pathway order: PathwayEnzymeReaction/644
pathway order: PathwayEnzymeReaction/603
pathway order: PathwayEnzymeReaction/602
pathway order: PathwayEnzymeReaction/646
pathway order: PathwayEnzymeReaction/641
pathway order: PathwayEnzymeReaction/640
pathway order: PathwayEnzymeReaction/643
pathway order: PathwayEnzymeReaction/642
pathway order: PathwayEnzymeReaction/3405
pathway order: PathwayEnzymeReaction/3404
pathway order: PathwayEnzymeReaction/616
pathway order: PathwayEnzymeReaction/615
pathway order: PathwayEnzymeReaction/618
pathway order: PathwayEnzymeReaction/617
pathway order: PathwayEnzymeReaction/612
pathway order: PathwayEnzymeReaction/611
pathway order: PathwayEnzymeReaction/655
pathway order: PathwayEnzymeReaction/614
pathway order: PathwayEnzymeReaction/977
pathway order: PathwayEnzymeReaction/613
pathway order: PathwayEnzymeReaction/976
pathway order: PathwayEnzymeReaction/610
pathway order: PathwayEnzymeReaction/609
pathway order: PathwayEnzymeReaction/608
pathway component: Reaction915
pathway component: 3.1.1.4
pathway component: 1.14.15.3
pathway component: Reaction914
pathway component: Reaction878
pathway component: Reaction911
pathway component: Reaction879
pathway component: Reaction912
pathway component: Reaction876
pathway component: 1.11.1.9
pathway component: Reaction910
pathway component: Reaction874

Compound/PW C000080 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 2.0

Reference/ChemSpider 7827803
type: UnificationXref
id: 7827803
db: ChemSpider

Reference/CAS 54845-95-3
type: UnificationXref
id: 54845-95-3
db: CAS

20-Hydroxyeicosatetraenoic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 20-Hydroxyeicosatetraenoic acid

Prostaglandin I2
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin I2

Leukotriene C4 synthase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Leukotriene C4 synthase

Reference/HMDB HMDB0004679
type: UnificationXref
id: HMDB0004679
db: HMDB

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/CAS 81246-84-6
type: UnificationXref
id: 81246-84-6
db: CAS

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C001162
type: ChemicalStructure
structure format: SMILES
structure data: OCCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O

Reference/CAS 35121-78-9
type: UnificationXref
id: 35121-78-9
db: CAS

Reference/HMDB HMDB0004673
type: UnificationXref
id: HMDB0004673
db: HMDB

1.14.13.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001477 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 5,6-Epoxy-8,11,14-eicosatrienoic acid
spontaneous: false
EC number: 1.14.13.-
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + Oxygen → 5,6-Epoxy-8,11,14-eicosatrienoic acid + Water
conversion direction: LEFT_TO_RIGHT

1.11.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000080 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006773 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001847 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006774 Cytoplasm/Stoichiometry/1.0
right: 5-HETE
right: Water
right: Oxidized glutathione
spontaneous: false
EC number: 1.11.1.9
left: 5-HPETE
left: Glutathione
name: 5-HPETE + 2 Glutathione → 5-HETE + Oxidized glutathione + Water
conversion direction: LEFT_TO_RIGHT

1.14.13.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001511 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 8,9-Epoxyeicosatrienoic acid
spontaneous: false
EC number: 1.14.13.-
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + Oxygen → 8,9-Epoxyeicosatrienoic acid + Water
conversion direction: LEFT_TO_RIGHT

1.13.11.34
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001030 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006774 Cytoplasm/Stoichiometry/1.0
right: Water
right: Leukotriene A4
spontaneous: false
EC number: 1.13.11.34
left: Oxygen
left: 5-HPETE
name: 5-HPETE + Oxygen → Leukotriene A4 + Water
conversion direction: LEFT_TO_RIGHT

Glutathione
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Glutathione

1.13.11.34
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000821 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006774 Cytoplasm/Stoichiometry/1.0
right: Water
right: 5-HPETE
spontaneous: false
EC number: 1.13.11.34
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + Oxygen → 5-HPETE + Water
conversion direction: LEFT_TO_RIGHT

Reference/CAS 219535-29-2
type: UnificationXref
id: 219535-29-2
db: CAS

12(R)-HPETE
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 12(R)-HPETE

Compound/PW C002103 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 6-Ketoprostaglandin E1
stoichiometric coefficient: 1.0

8,9-Epoxyeicosatrienoic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 8,9-Epoxyeicosatrienoic acid

Reference/KEGG Compound C02165
type: UnificationXref
id: C02165
db: KEGG Compound

5,6-DHET
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5,6-DHET

Reaction908
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002171 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002183 Endoplasmic Reticulum/Stoichiometry/1.0
right: 8-HETE
spontaneous: true
left: 8(S)-HPETE
name: 8(S)-HPETE → 8-HETE
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C02166
type: UnificationXref
id: C02166
db: KEGG Compound

Reaction909
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040453 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002179 Endoplasmic Reticulum/Stoichiometry/1.0
right: 12(R)-HETE
spontaneous: true
left: 12(R)-HPETE
name: 12(R)-HPETE → 12(R)-HETE
conversion direction: LEFT_TO_RIGHT

Reaction906
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006775 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: 19(S)-HETE
right: Water
spontaneous: false
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + Oxygen → 19(S)-HETE + Water
conversion direction: LEFT_TO_RIGHT

1.13.11.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002179 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: 12(R)-HPETE
spontaneous: false
EC number: 1.13.11.-
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + Oxygen → 12(R)-HPETE
conversion direction: LEFT_TO_RIGHT

Compound/PW C002174 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11,12,15-THETA
stoichiometric coefficient: 1.0

Reference/BioCyc ARACHIDONIC ACID
type: UnificationXref
id: ARACHIDONIC_ACID
db: BioCyc

ChemicalStructure/PW C000080
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5283202
type: UnificationXref
id: 5283202
db: PubChem-compound

Reference/HMDB HMDB0004680
type: UnificationXref
id: HMDB0004680
db: HMDB

Reference/PubChem-compound 5283203
type: UnificationXref
id: 5283203
db: PubChem-compound

Reference/PubChem-compound 5283205
type: UnificationXref
id: 5283205
db: PubChem-compound

Reference/HMDB HMDB0002265
type: UnificationXref
id: HMDB0002265
db: HMDB

Reference/HMDB HMDB0004684
type: UnificationXref
id: HMDB0004684
db: HMDB

Reaction878
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002100 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002398 Endoplasmic Reticulum/Stoichiometry/1.0
right: 15-Deoxy-d-12,14-PGJ2
spontaneous: true
left: δ-12-Prostaglandin J2
name: δ-12-Prostaglandin J2 → 15-Deoxy-d-12,14-PGJ2
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15843
type: UnificationXref
id: CHEBI:15843
db: ChEBI

Reaction879
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001726 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002103 Endoplasmic Reticulum/Stoichiometry/1.0
right: 6-Ketoprostaglandin E1
spontaneous: true
left: 6-Keto-prostaglandin F1a
name: 6-Keto-prostaglandin F1a → 6-Ketoprostaglandin E1
conversion direction: LEFT_TO_RIGHT

Reaction876
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040450 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002106 Endoplasmic Reticulum/Stoichiometry/1.0
right: 5,6-Epoxytetraene
spontaneous: true
left: 15(S)-HPETE
name: 15(S)-HPETE → 5,6-Epoxytetraene
conversion direction: LEFT_TO_RIGHT

1.11.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001986 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002106 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001847 Cytoplasm/Stoichiometry/1.0
right: Water
right: Oxidized glutathione
right: 15(S)-HETE
spontaneous: false
EC number: 1.11.1.9
left: 15(S)-HPETE
left: Glutathione
name: 15(S)-HPETE + 2 Glutathione → 15(S)-HETE + Oxidized glutathione + Water
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc 6Z8E10E14Z-5S12R-512-DIHYDROXYI
type: UnificationXref
id: 6Z8E10E14Z-5S12R-512-DIHYDROXYI
db: BioCyc

Reference/PubChem-compound 445049
type: UnificationXref
id: 445049
db: PubChem-compound

Reference/PubChem-compound 5280360
type: UnificationXref
id: 5280360
db: PubChem-compound

Reference/CAS 155976-51-5
type: UnificationXref
id: 155976-51-5
db: CAS

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/CAS 72059-45-1
type: UnificationXref
id: 72059-45-1
db: CAS

Reaction874
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001775 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000933 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
right: Leukotriene D4
right: L-Glutamic acid
spontaneous: false
left: Water
left: Leukotriene C4
name: Leukotriene C4 + Water → L-Glutamic acid + Leukotriene D4
conversion direction: LEFT_TO_RIGHT

Reaction875
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040450 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001030 Endoplasmic Reticulum/Stoichiometry/1.0
right: Leukotriene A4
spontaneous: true
left: 5,6-Epoxytetraene
name: 5,6-Epoxytetraene → Leukotriene A4
conversion direction: LEFT_TO_RIGHT

Reaction872
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000853 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001162 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 20-Hydroxy-leukotriene B4
right: NADP
spontaneous: false
left: Oxygen
left: NADPH
left: Leukotriene B4
name: Leukotriene B4 + NADPH + Oxygen → 20-Hydroxy-leukotriene B4 + NADP + Water
conversion direction: LEFT_TO_RIGHT

Reaction873
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000853 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002098 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: 12-Keto-leukotriene B4
spontaneous: true
left: Leukotriene B4
name: Leukotriene B4 → 12-Keto-leukotriene B4
conversion direction: LEFT_TO_RIGHT

Reaction871
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002644 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001162 Endoplasmic Reticulum/Stoichiometry/1.0
right: 20-Carboxy-leukotriene B4
spontaneous: true
left: 20-Hydroxy-leukotriene B4
name: 20-Hydroxy-leukotriene B4 → 20-Carboxy-leukotriene B4
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 4446204
type: UnificationXref
id: 4446204
db: ChemSpider

Reaction889
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040451 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002099 Endoplasmic Reticulum/Stoichiometry/1.0
right: Prostaglandin B2
spontaneous: true
left: Prostaglandin-c2
name: Prostaglandin-c2 → Prostaglandin B2
conversion direction: LEFT_TO_RIGHT

Reaction887
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040451 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001699 Endoplasmic Reticulum/Stoichiometry/1.0
right: Prostaglandin-c2
spontaneous: true
left: Prostaglandin A2
name: Prostaglandin A2 → Prostaglandin-c2
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc LEUKOTRIENE-C4
type: UnificationXref
id: LEUKOTRIENE-C4
db: BioCyc

Reaction888
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001121 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001820 Endoplasmic Reticulum/Stoichiometry/1.0
right: Thromboxane B2
spontaneous: true
left: Thromboxane A2
name: Thromboxane A2 → Thromboxane B2
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 27814
type: UnificationXref
id: CHEBI:27814
db: ChEBI

Leukotriene-B(4) omega-hydroxylase 2
type: ProteinReference
xref: Reference/UniProt Q08477
organism: Homo sapiens

Reference/HMDB HMDB0001509
type: UnificationXref
id: HMDB0001509
db: HMDB

Leukotriene-B(4) omega-hydroxylase 1
type: ProteinReference
xref: Reference/UniProt P78329
organism: BiologicalState10

20-Carboxy-leukotriene B4
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 20-Carboxy-leukotriene B4

Leukotriene A-4 hydrolase
type: ProteinReference
xref: Reference/UniProt P09960
organism: Homo sapiens

Reference/ChEBI CHEBI 33023
type: UnificationXref
id: CHEBI:33023
db: ChEBI

δ-12-Prostaglandin J2
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0004238
xref: Reference/PubChem-compound 5280885
xref: Reference/CAS 87893-54-7
xref: Reference/KEGG Compound C05958
xref: Reference/ChemSpider 4444408
xref: Reference/ChEBI CHEBI 28130
chemical formula: C20H30O4
molecular weight: 334.21442
structure: ChemicalStructure/PW C002100

Reference/ChEBI CHEBI 27820
type: UnificationXref
id: CHEBI:27820
db: ChEBI

15-Deoxy-d-12,14-PGJ2
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 15-Deoxy-d-12,14-PGJ2

Reference/UniProt P24557
type: UnificationXref
id: P24557
db: UniProt

6-Ketoprostaglandin E1
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28269
xref: Reference/ChemSpider 4444412
xref: Reference/CAS 67786-53-2
xref: Reference/HMDB HMDB0004241
xref: Reference/KEGG Compound C05962
xref: Reference/PubChem-compound 5280889
chemical formula: C20H32O6
molecular weight: 368.21988
structure: ChemicalStructure/PW C002103

Reference/HMDB HMDB0010217
type: UnificationXref
id: HMDB0010217
db: HMDB

Compound/PW C001699 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin A2
stoichiometric coefficient: 1.0

11-Dehydro-thromboxane B2
type: SmallMoleculeReference
xref: Reference/CAS 67910-12-7
xref: Reference/ChEBI CHEBI 28667
xref: Reference/ChemSpider 30776537
xref: Reference/HMDB HMDB0004242
xref: Reference/KEGG Compound C05964
xref: Reference/PubChem-compound 53477781
chemical formula: C20H32O6
molecular weight: 368.21988
structure: ChemicalStructure/PW C002104

Reaction885
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000889 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000949 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
right: Prostaglandin F2a
right: NADP
spontaneous: false
left: Prostaglandin E2
left: NADPH
name: NADPH + Prostaglandin E2 → NADP + Prostaglandin F2a
conversion direction: LEFT_TO_RIGHT

Reaction886
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001699 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000949 Endoplasmic Reticulum/Stoichiometry/1.0
right: Prostaglandin A2
spontaneous: true
left: Prostaglandin E2
name: Prostaglandin E2 → Prostaglandin A2
conversion direction: LEFT_TO_RIGHT

Reaction883
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001687 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001084 Endoplasmic Reticulum/Stoichiometry/1.0
right: Prostaglandin J2
spontaneous: true
left: Prostaglandin D2
name: Prostaglandin D2 → Prostaglandin J2
conversion direction: LEFT_TO_RIGHT

Reaction884
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001084 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006776 Cytoplasm/Stoichiometry/1.0
right: 11-Epi-PGF2a
right: NADP
spontaneous: false
left: Prostaglandin D2
left: NADPH
name: NADPH + Prostaglandin D2 → 11-Epi-PGF2a + NADP
conversion direction: LEFT_TO_RIGHT

Reaction881
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002100 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001687 Endoplasmic Reticulum/Stoichiometry/1.0
right: δ-12-Prostaglandin J2
spontaneous: true
left: Prostaglandin J2
name: Prostaglandin J2 → δ-12-Prostaglandin J2
conversion direction: LEFT_TO_RIGHT

Reaction882
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001028 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001726 Endoplasmic Reticulum/Stoichiometry/1.0
right: 6-Keto-prostaglandin F1a
spontaneous: true
left: Prostaglandin I2
name: Prostaglandin I2 → 6-Keto-prostaglandin F1a
conversion direction: LEFT_TO_RIGHT

Reference/CAS 877878-78-9
type: UnificationXref
id: 877878-78-9
db: CAS

Reaction880
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006229 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006773 Endoplasmic Reticulum/Stoichiometry/1.0
right: 5-KETE
spontaneous: true
left: 5-HETE
name: 5-HETE → 5-KETE
conversion direction: LEFT_TO_RIGHT

Etodolac
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Etodolac

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

1.14.13.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002170 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 11,12-Epoxyeicosatrienoic acid
spontaneous: false
EC number: 1.14.13.-
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + Oxygen → 11,12-Epoxyeicosatrienoic acid + Water
conversion direction: LEFT_TO_RIGHT

Arachidonic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Arachidonic acid

Reaction899
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001562 Cytoplasm/Stoichiometry/1.0
right: 11,12-DiHETrE
spontaneous: false
left: 11,12-Epoxyeicosatrienoic acid
left: Water
name: 11,12-Epoxyeicosatrienoic acid + Water → 11,12-DiHETrE
conversion direction: LEFT_TO_RIGHT

Reference/CAS 108437-64-5
type: UnificationXref
id: 108437-64-5
db: CAS

Reference/PubChem-compound 5280383
type: UnificationXref
id: 5280383
db: PubChem-compound

Prostaglandin A2
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002752
xref: Reference/ChEBI CHEBI 27820
xref: Reference/PubChem-compound 5280880
xref: Reference/KEGG Compound C05953
xref: Reference/ChemSpider 4444403
xref: Reference/CAS 13345-50-1
chemical formula: C20H30O4
molecular weight: 334.21442
structure: ChemicalStructure/PW C001699

Compound/PW C001529 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 14,15-DiHETrE
stoichiometric coefficient: 1.0

Compound/PW C002104 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11-Dehydro-thromboxane B2
stoichiometric coefficient: 1.0

Reference/KEGG Compound C02198
type: UnificationXref
id: C02198
db: KEGG Compound

Compound/PW C002179 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 12(R)-HPETE
stoichiometric coefficient: 1.0

Compound/PW C000889 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin F2a
stoichiometric coefficient: 1.0

Compound/PW C040451 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin-c2
stoichiometric coefficient: 1.0

1.14.14.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002172 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 16(R)-HETE
spontaneous: false
EC number: 1.14.14.1
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + Oxygen → 16(R)-HETE + Water
conversion direction: LEFT_TO_RIGHT

1.14.13.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002113 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 14,15-Epoxy-5,8,11-eicosatrienoic acid
spontaneous: false
EC number: 1.14.13.-
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + Oxygen → 14,15-Epoxy-5,8,11-eicosatrienoic acid + Water
conversion direction: LEFT_TO_RIGHT

1.14.14.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002174 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002389 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 11,12,15-THETA
spontaneous: false
EC number: 1.14.14.1
left: Oxygen
left: 15H-11,12-EETA
name: 15H-11,12-EETA + Oxygen → 11,12,15-THETA + Water
conversion direction: LEFT_TO_RIGHT

1.14.14.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002180 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002181 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 11,14,15-THETA
spontaneous: false
EC number: 1.14.14.1
left: Oxygen
left: 11H-14,15-EETA
name: 11H-14,15-EETA + Oxygen → 11,14,15-THETA + Water
conversion direction: LEFT_TO_RIGHT

1.14.14.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002389 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002106 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 15H-11,12-EETA
spontaneous: false
EC number: 1.14.14.1
left: 15(S)-HPETE
left: Oxygen
name: 15(S)-HPETE + Oxygen → 15H-11,12-EETA + Water
conversion direction: LEFT_TO_RIGHT

Reaction890
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001820 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002104 Endoplasmic Reticulum/Stoichiometry/1.0
right: 11-Dehydro-thromboxane B2
spontaneous: true
left: Thromboxane B2
name: Thromboxane B2 → 11-Dehydro-thromboxane B2
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q16647
type: UnificationXref
id: Q16647
db: UniProt

1.14.14.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002180 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002106 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: 11H-14,15-EETA
spontaneous: false
EC number: 1.14.14.1
left: 15(S)-HPETE
left: Oxygen
name: 15(S)-HPETE + Oxygen → 11H-14,15-EETA + Water
conversion direction: LEFT_TO_RIGHT

Carbonyl reductase [NADPH] 1
type: Protein
cellular location: Cytoplasm
entity reference: Carbonyl reductase [NADPH] 1

11,12-Epoxyeicosatrienoic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 11,12-Epoxyeicosatrienoic acid

Prostamide/prostaglandin F synthase
type: ProteinReference
xref: Reference/UniProt Q8TBF2
organism: Homo sapiens

Compound/PW C001121 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thromboxane A2
stoichiometric coefficient: 1.0

Compound/PW C006774 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-HPETE
stoichiometric coefficient: 1.0

Protein/1609 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Bifunctional epoxide hydrolase 2
stoichiometric coefficient: 2.0

Reference/CAS 54397-83-0
type: UnificationXref
id: 54397-83-0
db: CAS

5,6-Epoxy-8,11,14-eicosatrienoic acid
type: SmallMoleculeReference
xref: Reference/CAS 81246-84-6
xref: Reference/KEGG Compound C14768
xref: Reference/HMDB HMDB0002190
xref: Reference/ChemSpider 4446323
xref: Reference/PubChem-compound 5283202
xref: Reference/ChEBI CHEBI 34450
chemical formula: C20H32O3
molecular weight: 320.23514
structure: ChemicalStructure/PW C001477

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Compound/PW C001511 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 8,9-Epoxyeicosatrienoic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 34162
type: UnificationXref
id: CHEBI:34162
db: ChEBI

Reference/ChEBI CHEBI 15647
type: UnificationXref
id: CHEBI:15647
db: ChEBI

Reference/ChEBI CHEBI 16978
type: UnificationXref
id: CHEBI:16978
db: ChEBI

Reference/ChemSpider 24766559
type: UnificationXref
id: 24766559
db: ChemSpider

Reference/ChEBI CHEBI 15646
type: UnificationXref
id: CHEBI:15646
db: ChEBI

5-KETE
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 5-KETE

ReactionCatalysis191
type: Catalysis
controller: Prostaglandin-H2 D-isomerase
controlled: 5.3.99.2
control type: ACTIVATION

ReactionCatalysis192
type: Catalysis
controller: Prostamide/prostaglandin F synthase
controlled: 1.11.1.20
control type: ACTIVATION

ChemicalStructure/PW C001699
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 4444074
type: UnificationXref
id: 4444074
db: ChemSpider

Compound/PW C002106 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 15(S)-HPETE
stoichiometric coefficient: 1.0

Prostaglandin J2
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Prostaglandin J2

Prostaglandin E2
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Prostaglandin E2

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Prostaglandin A2
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Prostaglandin A2

Reference/CAS 213382-49-1
type: UnificationXref
id: 213382-49-1
db: CAS

Reference/ChEBI CHEBI 15651
type: UnificationXref
id: CHEBI:15651
db: ChEBI

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxygen

ReactionCatalysis188
type: Catalysis
controller: Prostaglandin E synthase
controlled: 5.3.99.3
control type: ACTIVATION

Reference/ChEBI CHEBI 34151
type: UnificationXref
id: CHEBI:34151
db: ChEBI

ReactionCatalysis187
type: Catalysis
controller: Prostacyclin synthase
controlled: 5.3.99.4
control type: ACTIVATION

Arachidonate 15-lipoxygenase
type: ProteinReference
xref: Reference/UniProt P16050
organism: Homo sapiens

Arachidonate 12-lipoxygenase, 12S-type
type: ProteinReference
xref: Reference/UniProt P18054
organism: Homo sapiens

Reference/ChEBI CHEBI 34157
type: UnificationXref
id: CHEBI:34157
db: ChEBI

Arachidonate 15-lipoxygenase B
type: ProteinReference
xref: Reference/UniProt O15296
organism: Homo sapiens

Prostaglandin G/H synthase 1
type: ProteinReference
xref: Reference/UniProt P23219
organism: Homo sapiens

Prostaglandin G/H synthase 2
type: ProteinReference
xref: Reference/UniProt P35354
organism: Homo sapiens

Arachidonate 5-lipoxygenase
type: ProteinReference
xref: Reference/UniProt P09917
organism: Homo sapiens

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/HMDB HMDB0002886
type: UnificationXref
id: HMDB0002886
db: HMDB

Arachidonate 12-lipoxygenase, 12R-type
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Arachidonate 12-lipoxygenase, 12R-type

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001477
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC\C=C/C\C=C/C\C=C/CC1OC1CCCC(O)=O

15H-11,12-EETA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 11954042
xref: Reference/KEGG Compound C14781
xref: Reference/HMDB HMDB0005050
xref: Reference/ChemSpider 10128337
xref: Reference/CAS 877878-78-9
chemical formula: C20H32O4
molecular weight: 336.23007
structure: ChemicalStructure/PW C002389

5,6-Epoxytetraene
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 5,6-Epoxytetraene

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Compound/PW C001028 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin I2
stoichiometric coefficient: 1.0

Oxygen
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxygen

Reference/ChemSpider 4444059
type: UnificationXref
id: 4444059
db: ChemSpider

12(S)-HPETE
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5280892
xref: Reference/KEGG Compound C05965
xref: Reference/ChEBI CHEBI 15626
xref: Reference/CAS 67675-13-2
xref: Reference/ChemSpider 4444415
xref: Reference/HMDB HMDB0004243
chemical formula: C20H32O4
molecular weight: 336.23007
structure: ChemicalStructure/PW C002105

15(S)-HPETE
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5280893
xref: Reference/CAS 70981-96-3
xref: Reference/KEGG Compound C05966
xref: Reference/ChEBI CHEBI 15628
xref: Reference/HMDB HMDB0004244
xref: Reference/ChemSpider 4444416
chemical formula: C20H32O4
molecular weight: 336.23007
structure: ChemicalStructure/PW C002106

Reference/ChEBI CHEBI 34146
type: UnificationXref
id: CHEBI:34146
db: ChEBI

ReactionCatalysis73
type: Catalysis
controller: Prostaglandin G/H synthase 1
controlled: 1.14.99.1
control type: ACTIVATION

Prostaglandin-H2 D-isomerase
type: Protein
cellular location: Cytoplasm
entity reference: Prostaglandin-H2 D-isomerase

Reference/CAS 13345-50-1
type: UnificationXref
id: 13345-50-1
db: CAS

ReactionCatalysis76
type: Catalysis
controller: Prostaglandin G/H synthase 1
controlled: 1.14.99.1
control type: ACTIVATION

Reference/ChEBI CHEBI 34145
type: UnificationXref
id: CHEBI:34145
db: ChEBI

ReactionCatalysis77
type: Catalysis
controller: Thromboxane-A synthase
controlled: 5.3.99.5
control type: ACTIVATION

Prostaglandin E2
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Prostaglandin E2

Reference/ChEBI CHEBI 34144
type: UnificationXref
id: CHEBI:34144
db: ChEBI

Reference/UniProt P23219
type: UnificationXref
id: P23219
db: UniProt

δ-12-Prostaglandin J2
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: δ-12-Prostaglandin J2

ChemicalStructure/PW C001687
type: ChemicalStructure
structure format: SMILES
structure data: CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)C=CC1=O

14,15-Epoxy-5,8,11-eicosatrienoic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 4446326
xref: Reference/HMDB HMDB0004264
xref: Reference/CAS 81276-03-1
xref: Reference/ChEBI CHEBI 34157
xref: Reference/KEGG Compound C14771
xref: Reference/PubChem-compound 5283205
chemical formula: C20H32O3
molecular weight: 320.23514
structure: ChemicalStructure/PW C002113

Compound/PW C002398 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 15-Deoxy-d-12,14-PGJ2
stoichiometric coefficient: 1.0

Prostaglandin E synthase
type: Complex
component stoichiometry: Protein/76 Endoplasmic Reticulum Membrane/Stoichiometry/3.0
cellular location: Endoplasmic Reticulum Membrane
component: Prostaglandin E synthase

Cytochrome P450 2B6
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 2B6

Reference/CAS 126873-49-2
type: UnificationXref
id: 126873-49-2
db: CAS

Reference/HMDB HMDB0014887
type: UnificationXref
id: HMDB0014887
db: HMDB

14,15-Epoxy-5,8,11-eicosatrienoic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 14,15-Epoxy-5,8,11-eicosatrienoic acid

Prostaglandin I2
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15552
xref: Reference/ChemSpider 4445566
xref: Reference/HMDB HMDB0001335
xref: Reference/BioCyc 5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
xref: Reference/PubChem-compound 5282411
xref: Reference/CAS 35121-78-9
xref: Reference/KEGG Compound C01312
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001028

Reference/HMDB HMDB0011137
type: UnificationXref
id: HMDB0011137
db: HMDB

Reference/HMDB HMDB0011136
type: UnificationXref
id: HMDB0011136
db: HMDB

Reference/ChemSpider 405289
type: UnificationXref
id: 405289
db: ChemSpider

Reference/HMDB HMDB0011135
type: UnificationXref
id: HMDB0011135
db: HMDB

Reference/HMDB HMDB0011134
type: UnificationXref
id: HMDB0011134
db: HMDB

Reference/UniProt O15296
type: UnificationXref
id: O15296
db: UniProt

Leukotriene A4
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15651
xref: Reference/HMDB HMDB0001337
xref: Reference/CAS 72059-45-1
xref: Reference/PubChem-compound 5280383
xref: Reference/ChemSpider 4444074
xref: Reference/BioCyc CPD-8892
xref: Reference/KEGG Compound C00909
chemical formula: C20H30O3
molecular weight: 318.21948
structure: ChemicalStructure/PW C001030

Compound/PW C001775 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Leukotriene D4
stoichiometric coefficient: 1.0

Reference/CAS 54397-85-2
type: UnificationXref
id: 54397-85-2
db: CAS

Reference/HMDB HMDB0001335
type: UnificationXref
id: HMDB0001335
db: HMDB

Reference/HMDB HMDB0001337
type: UnificationXref
id: HMDB0001337
db: HMDB

Reference/ChEBI CHEBI 15627
type: UnificationXref
id: CHEBI:15627
db: ChEBI

Reference/ChEBI CHEBI 15626
type: UnificationXref
id: CHEBI:15626
db: ChEBI

Reference/ChEBI CHEBI 15628
type: UnificationXref
id: CHEBI:15628
db: ChEBI

Reference/CAS 98462-03-4
type: UnificationXref
id: 98462-03-4
db: CAS

Compound/PW C001477 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5,6-Epoxy-8,11,14-eicosatrienoic acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003080
type: UnificationXref
id: HMDB0003080
db: HMDB

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

ChemicalStructure/PW C001814
type: ChemicalStructure
structure format: SMILES

11,12,15-THETA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 11954043
xref: Reference/ChemSpider 10128338
xref: Reference/KEGG Compound C14782
xref: Reference/HMDB HMDB0004684
chemical formula: C20H34O5
molecular weight: 354.24063
structure: ChemicalStructure/PW C002174

5-HPETE
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5283171
xref: Reference/CAS 74581-83-2
xref: Reference/KEGG Compound C05356
xref: Reference/ChemSpider 4446295
xref: Reference/HMDB HMDB0011135
chemical formula: C20H32O4
molecular weight: 336.23007
structure: ChemicalStructure/PW C006774

19(S)-HETE
type: SmallMoleculeReference
xref: Reference/KEGG Compound C14749
xref: Reference/CAS 79551-85-2
xref: Reference/PubChem-compound 9548883
xref: Reference/ChEBI CHEBI 34185
xref: Reference/ChemSpider 7827806
xref: Reference/HMDB HMDB0011136
chemical formula: C20H32O3
molecular weight: 320.23514
structure: ChemicalStructure/PW C006775

Reference/PubChem-compound 5255796
type: UnificationXref
id: 5255796
db: PubChem-compound

5-HETE
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5280733
xref: Reference/CAS 70608-72-9
xref: Reference/ChemSpider 4444314
xref: Reference/KEGG Compound C04805
xref: Reference/ChEBI CHEBI 28209
xref: Reference/HMDB HMDB0011134
chemical formula: C20H32O3
molecular weight: 320.23514
structure: ChemicalStructure/PW C006773

12(R)-HPETE
type: SmallMoleculeReference
xref: Reference/KEGG Compound C14812
xref: Reference/PubChem-compound 9548885
xref: Reference/ChemSpider 7827808
xref: Reference/HMDB HMDB0004692
xref: Reference/CAS 126873-49-2
xref: Reference/ChEBI CHEBI 34145
chemical formula: C20H32O4
molecular weight: 336.23007
structure: ChemicalStructure/PW C002179

11-Epi-PGF2a
type: SmallMoleculeReference
xref: Reference/PubChem-compound 53480669
xref: Reference/KEGG Compound C05959
xref: Reference/HMDB HMDB0011137
xref: Reference/ChEBI CHEBI 27595
chemical formula: C20H34O5
molecular weight: 354.24063
structure: ChemicalStructure/PW C006776

Compound/PW C040453 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 12(R)-HETE
stoichiometric coefficient: 1.0

11,12-Epoxyeicosatrienoic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C14770
xref: Reference/PubChem-compound 5353269
xref: Reference/ChemSpider 4510033
xref: Reference/HMDB HMDB0004673
xref: Reference/CAS 81276-02-0
chemical formula: C20H32O3
molecular weight: 320.23514
structure: ChemicalStructure/PW C002170

8-HETE
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0004679
xref: Reference/CAS 98462-03-4
xref: Reference/PubChem-compound 5283154
xref: Reference/ChemSpider 4446278
xref: Reference/KEGG Compound C14776
xref: Reference/ChEBI CHEBI 34486
chemical formula: C20H32O3
molecular weight: 320.23514
structure: ChemicalStructure/PW C002171

Glutathione peroxidase 1
type: Complex
component stoichiometry: Protein/773 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Glutathione peroxidase 1

16(R)-HETE
type: SmallMoleculeReference
xref: Reference/PubChem-compound 9548884
xref: Reference/ChEBI CHEBI 34162
xref: Reference/ChemSpider 7827807
xref: Reference/HMDB HMDB0004680
xref: Reference/KEGG Compound C14778
chemical formula: C20H32O3
molecular weight: 320.23514
structure: ChemicalStructure/PW C002172

5,6-Epoxytetraene
type: SmallMoleculeReference
xref: Reference/KEGG Compound C14815
xref: Reference/HMDB HMDB0061111
xref: Reference/ChEBI CHEBI 64095
xref: Reference/ChemSpider 10128355
xref: Reference/PubChem-compound 11954060
chemical formula: C20H30O4
molecular weight: 334.21442
structure: ChemicalStructure/PW C040450

Prostaglandin D2
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15555
xref: Reference/ChemSpider 395250
xref: Reference/HMDB HMDB0001403
xref: Reference/BioCyc 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O
xref: Reference/PubChem-compound 448457
xref: Reference/KEGG Compound C00696
xref: Reference/CAS 41598-07-6
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001084

Reference/ChemSpider 4470730
type: UnificationXref
id: 4470730
db: ChemSpider

Prostaglandin-c2
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27555
xref: Reference/HMDB HMDB0060095
xref: Reference/PubChem-compound 5280882
xref: Reference/KEGG Compound C05955
xref: Reference/ChemSpider 4444405
chemical formula: C20H30O4
molecular weight: 334.21442
structure: ChemicalStructure/PW C040451

12(S)-HETE
type: SmallMoleculeReference
xref: Reference/CAS 54397-83-0
xref: Reference/PubChem-compound 5283155
xref: Reference/ChemSpider 4446279
xref: Reference/ChEBI CHEBI 34146
xref: Reference/HMDB HMDB0061118
xref: Reference/KEGG Compound C14777
chemical formula: C20H32O3
molecular weight: 320.23514
structure: ChemicalStructure/PW C040452

Reference/PubChem-compound 53480669
type: UnificationXref
id: 53480669
db: PubChem-compound

Compound/PW C002183 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 8(S)-HPETE
stoichiometric coefficient: 1.0

12(R)-HETE
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5283156
xref: Reference/HMDB HMDB0061119
xref: Reference/KEGG Compound C14822
xref: Reference/ChemSpider 4446280
xref: Reference/ChEBI CHEBI 34144
chemical formula: C20H32O3
molecular weight: 320.23514
structure: ChemicalStructure/PW C040453

Compound/PW C002106 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 15(S)-HPETE
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001820
type: ChemicalStructure
structure format: SMILES

Compound/PW C000821 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Arachidonic acid
stoichiometric coefficient: 1.0

Arachidonate 12-lipoxygenase, 12S-type
type: Protein
cellular location: Cytoplasm
entity reference: Arachidonate 12-lipoxygenase, 12S-type

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

11H-14,15-EETA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C14813
xref: Reference/PubChem-compound 11954058
xref: Reference/CAS 219535-29-2
xref: Reference/HMDB HMDB0004693
xref: Reference/ChemSpider 10128353
chemical formula: C20H32O4
molecular weight: 336.23007
structure: ChemicalStructure/PW C002180

11,14,15-THETA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C14814
xref: Reference/PubChem-compound 11954059
xref: Reference/ChemSpider 10128354
xref: Reference/HMDB HMDB0004694
chemical formula: C20H34O5
molecular weight: 354.24063
structure: ChemicalStructure/PW C002181

Reference/ChemSpider 10128355
type: UnificationXref
id: 10128355
db: ChemSpider

NADPH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADPH

Reference/ChemSpider 10128354
type: UnificationXref
id: 10128354
db: ChemSpider

8(S)-HPETE
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0004699
xref: Reference/KEGG Compound C14823
xref: Reference/ChEBI CHEBI 34487
xref: Reference/ChemSpider 7827803
xref: Reference/PubChem-compound 9548880
chemical formula: C20H32O4
molecular weight: 336.23007
structure: ChemicalStructure/PW C002183

Reference/ChemSpider 10128353
type: UnificationXref
id: 10128353
db: ChemSpider

Reference/ChemSpider 4444411
type: UnificationXref
id: 4444411
db: ChemSpider

Cytochrome P450 2C8
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 2C8

Reference/ChemSpider 4444412
type: UnificationXref
id: 4444412
db: ChemSpider

ChemicalStructure/PW C000949
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 34185
type: UnificationXref
id: CHEBI:34185
db: ChEBI

Reference/HMDB HMDB0060095
type: UnificationXref
id: HMDB0060095
db: HMDB

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Arachidonate 12-lipoxygenase, 12R-type
type: ProteinReference
xref: Reference/UniProt O75342
organism: Homo sapiens

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

15-Deoxy-d-12,14-PGJ2
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5311211
xref: Reference/ChemSpider 4470730
xref: Reference/CAS 87893-55-8
xref: Reference/ChEBI CHEBI 607727
xref: Reference/KEGG Compound C14717
xref: Reference/HMDB HMDB0005079
chemical formula: C20H28O3
molecular weight: 316.20386
structure: ChemicalStructure/PW C002398

Prostaglandin H2
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00427
xref: Reference/ChEBI CHEBI 15554
xref: Reference/CAS 42935-17-1
xref: Reference/BioCyc PROSTAGLANDIN-H2
xref: Reference/ChemSpider 392800
xref: Reference/PubChem-compound 445049
xref: Reference/HMDB HMDB0001381
chemical formula: C20H32O5
molecular weight: 352.22498
structure: ChemicalStructure/PW C001068

Reference/UniProt P78329
type: UnificationXref
id: P78329
db: UniProt

Arachidonate 15-lipoxygenase B
type: Protein
cellular location: Cytoplasm
entity reference: Arachidonate 15-lipoxygenase B

Reference/UniProt P18054
type: UnificationXref
id: P18054
db: UniProt

Reference/ChemSpider 4444415
type: UnificationXref
id: 4444415
db: ChemSpider

Reference/ChemSpider 4444416
type: UnificationXref
id: 4444416
db: ChemSpider

Reference/ChemSpider 4444400
type: UnificationXref
id: 4444400
db: ChemSpider

Reference/ChemSpider 4444401
type: UnificationXref
id: 4444401
db: ChemSpider

Reference/ChEBI CHEBI 17858
type: UnificationXref
id: CHEBI:17858
db: ChEBI

Reference/HMDB HMDB0005050
type: UnificationXref
id: HMDB0005050
db: HMDB

Reference/ChEBI CHEBI 28728
type: UnificationXref
id: CHEBI:28728
db: ChEBI

Reference/PubChem-compound 107873
type: UnificationXref
id: 107873
db: PubChem-compound

15H-11,12-EETA
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 15H-11,12-EETA

8-Isoprostane
type: SmallMoleculeReference
xref: Reference/CAS 155976-51-5
xref: Reference/HMDB HMDB0004659
xref: Reference/ChemSpider 97008
xref: Reference/KEGG Compound C13809
xref: Reference/PubChem-compound 107873
xref: Reference/ChEBI CHEBI 33023
chemical formula: C20H40
molecular weight: 280.313
structure: ChemicalStructure/PW C002163

Reference/ChEBI CHEBI 27647
type: UnificationXref
id: CHEBI:27647
db: ChEBI

Reference/ChemSpider 4444407
type: UnificationXref
id: 4444407
db: ChemSpider

Reference/ChemSpider 4444408
type: UnificationXref
id: 4444408
db: ChemSpider

Reference/ChemSpider 4444403
type: UnificationXref
id: 4444403
db: ChemSpider

Reference/ChemSpider 4444405
type: UnificationXref
id: 4444405
db: ChemSpider

Reference/ChemSpider 4444406
type: UnificationXref
id: 4444406
db: ChemSpider

Reference/ChemSpider 4445566
type: UnificationXref
id: 4445566
db: ChemSpider

Reference/KEGG Compound C00639
type: UnificationXref
id: C00639
db: KEGG Compound

Compound/PW C006388 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: LysoPC(14:0/0:0)
stoichiometric coefficient: 1.0

Thromboxane B2
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Thromboxane B2

5-HETE
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 5-HETE

Reference/ChemSpider 3192
type: UnificationXref
id: 3192
db: ChemSpider

Compound/PW C001030 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Leukotriene A4
stoichiometric coefficient: 1.0

Leukotriene-B(4) omega-hydroxylase 2
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Leukotriene-B(4) omega-hydroxylase 2

Reference/UniProt P16050
type: UnificationXref
id: P16050
db: UniProt

Reference/PubChem-compound 5280724
type: UnificationXref
id: 5280724
db: PubChem-compound

15(S)-HETE
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 15(S)-HETE

Reference/ChEBI CHEBI 63970
type: UnificationXref
id: CHEBI:63970
db: ChEBI

Reference/UniProt Q16873
type: UnificationXref
id: Q16873
db: UniProt

12(S)-HPETE
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 12(S)-HPETE

8(S)-HPETE
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 8(S)-HPETE

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

12-KETE
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5283162
xref: Reference/HMDB HMDB0013633
xref: Reference/ChEBI CHEBI 34151
xref: Reference/KEGG Compound C14807
xref: Reference/CAS 108437-64-5
xref: Reference/ChemSpider 4446286
chemical formula: C20H30O3
molecular weight: 318.21948
structure: ChemicalStructure/PW C008524

Compound/PW C000853 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Leukotriene B4
stoichiometric coefficient: 1.0

Compound/PW C001028 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin I2
stoichiometric coefficient: 1.0

Reference/KEGG Compound C14807
type: UnificationXref
id: C14807
db: KEGG Compound

Reference/ChEBI CHEBI 63969
type: UnificationXref
id: CHEBI:63969
db: ChEBI

Reference/ChEBI CHEBI 63966
type: UnificationXref
id: CHEBI:63966
db: ChEBI

Reference/PathWhiz PW000129
type: UnificationXref
id: PW000129
db: PathWhiz

Leukotriene C4
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Leukotriene C4

Reference/HMDB HMDB0005079
type: UnificationXref
id: HMDB0005079
db: HMDB

Reference/UniProt P05181
type: UnificationXref
id: P05181
db: UniProt

Reference/CAS 41598-07-6
type: UnificationXref
id: 41598-07-6
db: CAS

Reference/CAS 81276-02-0
type: UnificationXref
id: 81276-02-0
db: CAS

Reference/KEGG Compound C14815
type: UnificationXref
id: C14815
db: KEGG Compound

5.3.99.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001028 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Prostaglandin I2
spontaneous: false
EC number: 5.3.99.4
left: Prostaglandin H2
name: Prostaglandin H2 → Prostaglandin I2
conversion direction: LEFT_TO_RIGHT

5.3.99.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000949 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Prostaglandin E2
spontaneous: false
EC number: 5.3.99.3
left: Prostaglandin H2
name: Prostaglandin H2 → Prostaglandin E2
conversion direction: LEFT_TO_RIGHT

Compound/PW C002180 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11H-14,15-EETA
stoichiometric coefficient: 1.0

Reference/KEGG Compound C14814
type: UnificationXref
id: C14814
db: KEGG Compound

Reference/UniProt P42330
type: UnificationXref
id: P42330
db: UniProt

Reference/KEGG Compound C14813
type: UnificationXref
id: C14813
db: KEGG Compound

Reference/KEGG Compound C14812
type: UnificationXref
id: C14812
db: KEGG Compound

Compound/PW C000853 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Leukotriene B4
stoichiometric coefficient: 1.0

Prostaglandin H2
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Prostaglandin H2

Prostaglandin E synthase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Prostaglandin E synthase

1.14.99.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000821 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001814 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/2.0
right: Prostaglandin G2
spontaneous: false
EC number: 1.14.99.1
left: Oxygen
left: Arachidonic acid
name: Arachidonic acid + 2 Oxygen → Prostaglandin G2
conversion direction: LEFT_TO_RIGHT

5.3.99.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001068 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001084 Cytoplasm/Stoichiometry/1.0
right: Prostaglandin D2
spontaneous: false
EC number: 5.3.99.2
left: Prostaglandin H2
name: Prostaglandin H2 → Prostaglandin D2
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 63974
type: UnificationXref
id: CHEBI:63974
db: ChEBI

1.11.1.20
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000889 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001068 Cytoplasm/Stoichiometry/1.0
right: Prostaglandin F2a
spontaneous: false
EC number: 1.11.1.20
left: Prostaglandin H2
name: Prostaglandin H2 → Prostaglandin F2a
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 5280745
type: UnificationXref
id: 5280745
db: PubChem-compound

Reference/BioCyc 20-OH-LTB4
type: UnificationXref
id: 20-OH-LTB4
db: BioCyc

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADP

Reference/KEGG Compound C00427
type: UnificationXref
id: C00427
db: KEGG Compound

Compound/PW C002181 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 11,14,15-THETA
stoichiometric coefficient: 1.0

Compound/PW C001068 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prostaglandin H2
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001847
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5280733
type: UnificationXref
id: 5280733
db: PubChem-compound

Reference/KEGG Compound C14823
type: UnificationXref
id: C14823
db: KEGG Compound

Reference/ChemSpider 10128338
type: UnificationXref
id: 10128338
db: ChemSpider

Arachidonate 5-lipoxygenase
type: Protein
cellular location: Cytoplasm
entity reference: Arachidonate 5-lipoxygenase

Reference/ChemSpider 10128337
type: UnificationXref
id: 10128337
db: ChemSpider

Reference/KEGG Compound C14822
type: UnificationXref
id: C14822
db: KEGG Compound

2,3-Dinor-8iso prostaglandin F2α
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: 2,3-Dinor-8iso prostaglandin F2α