Sodium/potassium-transporting ATPase subunit alpha-3
type: ProteinReference
xref: Reference/UniProt P13637

Reference/UniProt Q92536
type: UnificationXref
id: Q92536
db: UniProt

Transport112
type: Transport
participant stoichiometry: Compound/PW C001299 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001299 Extracellular Space/Stoichiometry/1.0
right: Triamterene
spontaneous: false
left: Triamterene
name: Triamterene (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Triamterene
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Triamterene
name: SubPathwayInhibitor

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

Aldosterone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000037
xref: Reference/PubChem-compound 24758425
xref: Reference/ChemSpider 24774738
xref: Reference/KEGG Compound C01780
xref: Reference/BioCyc ALDOSTERONE
xref: Reference/ChEBI CHEBI 27584
xref: Reference/CAS 52-39-1
chemical formula: C21H28O5
molecular weight: 360.19366
structure: ChemicalStructure/PW C000026

ChemicalStructure/PW C000448
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CS)C(O)=O

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Sodium/potassium-transporting ATPase subunit beta-3
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-3

TransportCatalysis98
type: Catalysis
controller: Neutral and basic amino acid transport protein rBAT/B(0,+)-type amino acid transporter 1
controlled: Transport127
control type: ACTIVATION

Reference/BioCyc CYS
type: UnificationXref
id: CYS
db: BioCyc

Amiloride-sensitive sodium channel subunit delta
type: Protein
cellular location: Cell Membrane
entity reference: Amiloride-sensitive sodium channel subunit delta

Reference/UniProt P08195
type: UnificationXref
id: P08195
db: UniProt

SLC3A2/4F2hc Y+L amino acid transporter 2
type: Complex
component: 4F2 cell-surface antigen heavy chain
component: Y+L amino acid transporter 2

Reference/UniProt Q07837
type: UnificationXref
id: Q07837
db: UniProt

Sodium/potassium-transporting ATPase subunit gamma
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit gamma

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/CAS 57-13-6
type: UnificationXref
id: 57-13-6
db: CAS

Solute carrier family 22 member 2
type: ProteinReference
xref: Reference/UniProt O15244

Reference/ChEBI CHEBI 33709
type: UnificationXref
id: CHEBI:33709
db: ChEBI

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

L-Cysteine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Cysteine

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Solute carrier family 12 member 6
type: Protein
entity reference: Solute carrier family 12 member 6

Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/UniProt Q4U2R8
type: UnificationXref
id: Q4U2R8
db: UniProt

Imino acids
type: SmallMolecule
cellular location: Cytosol
entity reference: Imino acids

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Transport127
type: Transport
participant stoichiometry: Compound/PW C000448 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytosol/Stoichiometry/1.0
right: L-Cysteine
spontaneous: false
left: L-Cysteine
name: L-Cysteine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/Generic51 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Imino acids
stoichiometric coefficient: 1.0

Reference/UniProt P05023
type: UnificationXref
id: P05023
db: UniProt

Reference/KEGG Compound D00386
type: UnificationXref
id: D00386
db: KEGG Compound

Reference/UniProt P05026
type: UnificationXref
id: P05026
db: UniProt

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Solute carrier family 22 member 6
type: Protein
entity reference: Solute carrier family 22 member 6

Reference/UniProt P14415
type: UnificationXref
id: P14415
db: UniProt

4F2 cell-surface antigen heavy chain
type: Protein
entity reference: 4F2 cell-surface antigen heavy chain

Reference/KEGG Compound C01780
type: UnificationXref
id: C01780
db: KEGG Compound

Compound/PW C000026 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Aldosterone
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00698
type: UnificationXref
id: C00698
db: KEGG Compound

Sodium- and chloride-dependent transporter XTRP3
type: Protein
entity reference: Sodium- and chloride-dependent transporter XTRP3

Reference/ChemSpider 1143
type: UnificationXref
id: 1143
db: ChemSpider

Reference/ChEBI CHEBI 117411
type: UnificationXref
id: CHEBI:117411
db: ChEBI

Reference/ChEBI CHEBI 17561
type: UnificationXref
id: CHEBI:17561
db: ChEBI

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/UniProt P51800
type: UnificationXref
id: P51800
db: UniProt

Y+L amino acid transporter 1
type: Protein
entity reference: Y+L amino acid transporter 1

Reference/BioCyc UREA
type: UnificationXref
id: UREA
db: BioCyc

Chloride ion
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17996
xref: Reference/BioCyc CPD-4521
xref: Reference/PubChem-compound 312
xref: Reference/KEGG Compound C00698
xref: Reference/HMDB HMDB0000492
xref: Reference/ChemSpider 306
xref: Reference/CAS 16887-00-6
chemical formula: Cl
molecular weight: 34.968853
structure: ChemicalStructure/PW C000374

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: ProteinReference
xref: Reference/UniProt B7ZKV8

Compound/Generic39 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Cation
stoichiometric coefficient: 1.0

Reference/PubChem-compound 24758425
type: UnificationXref
id: 24758425
db: PubChem-compound

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Chloride channel protein ClC-Ka
type: ProteinReference
xref: Reference/UniProt P51800

SLC3A2/4F2hc Y+L amino acid transporter 1
type: Complex
component: Y+L amino acid transporter 1
component: 4F2 cell-surface antigen heavy chain

Compound/PW C000374 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 1.0

Aquaporin-3
type: Protein
entity reference: Aquaporin-3

Sodium/potassium ATPase
type: Complex
component: Sodium/potassium-transporting ATPase subunit beta-2
component: Sodium/potassium-transporting ATPase subunit alpha-1
component: ATPase, (Na+)/K+ transporting, beta 4 polypeptide
component: Sodium/potassium-transporting ATPase subunit beta-1
component: Sodium/potassium-transporting ATPase subunit gamma
component: Sodium/potassium-transporting ATPase subunit alpha-4
component: Sodium/potassium-transporting ATPase subunit alpha-2
component: Sodium/potassium-transporting ATPase subunit beta-3
component: Sodium/potassium-transporting ATPase subunit alpha-3

SLC3A2/4F2hc Large neutral amino acids transporter small subunit 1
type: Complex
component: Large neutral amino acids transporter small subunit 1
component: 4F2 cell-surface antigen heavy chain

SLC3A2/4F2hc Large neutral amino acids transporter small subunit 2
type: Complex
component: Large neutral amino acids transporter small subunit 2
component: 4F2 cell-surface antigen heavy chain

Reference/PubChem-compound 5862
type: UnificationXref
id: 5862
db: PubChem-compound

Y+L amino acid transporter 2
type: Protein
entity reference: Y+L amino acid transporter 2

Urea
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Urea

ProteinComplex/672 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Active Mineralocorticoid receptor
stoichiometric coefficient: 1.0

Sodium/potassium-transporting ATPase subunit beta-2
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-2

Excitatory amino acid transporter 3
type: Protein
entity reference: Excitatory amino acid transporter 3

Sodium/potassium-transporting ATPase subunit beta-1
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-1

Reference/ChEBI CHEBI 26271
type: UnificationXref
id: CHEBI:26271
db: ChEBI

Amiloride-sensitive sodium channel subunit delta
type: Protein
entity reference: Amiloride-sensitive sodium channel subunit delta

ChemicalStructure/PW C000200
type: ChemicalStructure
structure format: SMILES
structure data: NC(N)=O

Solute carrier family 12 member 3
type: Protein
entity reference: Solute carrier family 12 member 3

Amiloride-sensitive sodium channel subunit beta
type: Protein
entity reference: Amiloride-sensitive sodium channel subunit beta

Triamterene inhibition of Epithelial Sodium Channel
type: Pathway
name: InhibitorySubPathway

Reference/ChEBI CHEBI 15705
type: UnificationXref
id: CHEBI:15705
db: ChEBI

Reference/BioCyc ALDOSTERONE
type: UnificationXref
id: ALDOSTERONE
db: BioCyc

Reference/UniProt P37088
type: UnificationXref
id: P37088
db: UniProt

Imino acids
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Imino acids

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 1.0

Reference/CAS 396-01-0
type: UnificationXref
id: 396-01-0
db: CAS

Sodium/potassium-transporting ATPase subunit gamma
type: ProteinReference
xref: Reference/UniProt P54710

Aquaporin-2
type: Protein
entity reference: Aquaporin-2

L-Amino acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15705

ATP-sensitive inward rectifier potassium channel 1
type: Protein
entity reference: ATP-sensitive inward rectifier potassium channel 1

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/ChemSpider 24774738
type: UnificationXref
id: 24774738
db: ChemSpider

Large Neutral Amino Acids
type: SmallMolecule
cellular location: Cytosol
entity reference: Large Neutral Amino Acids

Aquaporin-1
type: ProteinReference
xref: Reference/UniProt P29972

ChemicalStructure/PW C000374
type: ChemicalStructure
structure format: SMILES
structure data: [Cl-]

Reference/HMDB HMDB0000574
type: UnificationXref
id: HMDB0000574
db: HMDB

Transport10362
type: Transport
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Water
spontaneous: false
left: Water
name: Water (→) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Chloride ion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Chloride ion

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Large neutral amino acids transporter small subunit 2
type: ProteinReference
xref: Reference/UniProt Q9UHI5

Reference/ChEBI CHEBI 25697
type: UnificationXref
id: CHEBI:25697
db: ChEBI

Reference/ChEBI CHEBI 25696
type: UnificationXref
id: CHEBI:25696
db: ChEBI

TransportCatalysis1532
type: Catalysis
controller: Aquaporin-2
controlled: Transport10362
control type: ACTIVATION

Reference/PubChem-compound 312
type: UnificationXref
id: 312
db: PubChem-compound

Sodium/potassium-transporting ATPase subunit beta-3
type: ProteinReference
xref: Reference/UniProt P54709

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Sodium/potassium-transporting ATPase subunit alpha-4
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-4

Transport56
type: Transport
participant stoichiometry: Compound/Generic32 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic32 Cytosol/Stoichiometry/1.0
right: Organic Anion
spontaneous: false
left: Organic Anion
name: Organic Anion (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Transport59
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Chloride ion
right: Potassium
spontaneous: false
left: Chloride ion
left: Potassium
name: Chloride ion (→), Potassium (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Urea transporter 2
type: Protein
entity reference: Urea transporter 2

Transport58
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Chloride ion
right: Potassium
right: Sodium
spontaneous: false
left: Sodium
left: Chloride ion
left: Potassium
name: Sodium (→), Potassium (→), Chloride ion (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport53
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/2.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Urea
type: SmallMolecule
cellular location: Cytosol
entity reference: Urea

Transport52
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Chloride ion
right: Sodium
spontaneous: false
left: Sodium
left: Chloride ion
name: Chloride ion (→), Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P13637
type: UnificationXref
id: P13637
db: UniProt

Transport55
type: Transport
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Water
spontaneous: false
left: Water
name: Water (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Compound/PW C001299 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Triamterene
stoichiometric coefficient: 1.0

Transport54
type: Transport
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
right: Chloride ion
spontaneous: false
left: Chloride ion
name: Chloride ion (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport60
type: Transport
participant stoichiometry: Compound/Generic39 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic39 Extracellular Space/Stoichiometry/1.0
right: Organic Cation
spontaneous: false
left: Organic Cation
name: Organic Cation (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Compound/Generic50 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Large Neutral Amino Acids
stoichiometric coefficient: 1.0

Sodium-coupled neutral amino acid transporter 4
type: Protein
entity reference: Sodium-coupled neutral amino acid transporter 4

Sodium/potassium-transporting ATPase subunit alpha-1
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-1

Transport62
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

ChemicalStructure/PW C000026
type: ChemicalStructure
structure format: SMILES

Triamterene
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001940
xref: Reference/KEGG Compound D00386
xref: Reference/CAS 396-01-0
xref: Reference/PubChem-compound 5546
xref: Reference/ChemSpider 5345
xref: Reference/ChEBI CHEBI 117411
chemical formula: C12H11N7
molecular weight: 253.10759
structure: ChemicalStructure/PW C001299

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Compound/PW C000448 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Hydrogen carbonate
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen carbonate

Reference/UniProt P54710
type: UnificationXref
id: P54710
db: UniProt

Organic Anion
type: SmallMolecule
cellular location: Cytosol
entity reference: Organic Anion

Solute carrier family 12 member 6
type: ProteinReference
xref: Reference/UniProt Q9UHW9

Neutral and basic amino acid transport protein rBAT
type: Protein
entity reference: Neutral and basic amino acid transport protein rBAT

Amiloride-sensitive sodium channel subunit alpha
type: Protein
entity reference: Amiloride-sensitive sodium channel subunit alpha

B(0,+)-type amino acid transporter 1
type: Protein
entity reference: B(0,+)-type amino acid transporter 1

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Triamterene Action Pathway
type: Pathway
pathway order: PathwayTransport/1130
pathway order: PathwayTransport/1174
pathway order: PathwayTransport/3052
pathway order: PathwayTransport/2499808
pathway order: PathwayTransport/1572
pathway order: PathwayTransport/1131
pathway order: PathwayTransport/1571
pathway order: PathwayTransport/1791
pathway order: PathwayTransport/1178
pathway order: PathwayTransport/1598
pathway order: PathwayTransport/1234
pathway order: PathwayTransport/1237
pathway order: PathwayTransport/2121630
pathway order: PathwayTransport/2499807
pathway order: PathwayTransport/1559
pathway order: PathwaySubPathway/300
pathway order: PathwaySubPathway/301
pathway order: PathwayTransport/1583
pathway order: PathwayTransport/1142
pathway order: PathwayTransport/1563
pathway order: PathwayTransport/1585
pathway order: PathwayTransport/1565
pathway order: PathwayTransport/2499813
pathway order: PathwayTransport/2499811
pathway order: PathwayTransport/1566
pathway order: PathwayTransport/1209
pathway component: TransportCatalysis187
pathway component: Transport112
pathway component: SubPathwayControl300
pathway component: TransportCatalysis78
pathway component: TransportCatalysis33
pathway component: TransportCatalysis98
pathway component: TransportCatalysis32
pathway component: TransportCatalysis71
pathway component: Transport10362
pathway component: TransportCatalysis30
pathway component: TransportCatalysis51
pathway component: TransportCatalysis73
pathway component: TransportCatalysis72
pathway component: TransportCatalysis50
pathway component: Transcription/Translation
pathway component: TransportCatalysis1532
pathway component: Transport101
pathway component: TransportCatalysis29
pathway component: TransportCatalysis4764
pathway component: TransportCatalysis24
pathway component: TransportCatalysis68
pathway component: TransportCatalysis23
pathway component: Transport56
pathway component: TransportCatalysis22
pathway component: Transport59
pathway component: Transport58
pathway component: Transport53
pathway component: TransportCatalysis28
pathway component: Transport52
pathway component: TransportCatalysis27
pathway component: Transport13687
pathway component: Transport55
pathway component: Transport54
pathway component: TransportCatalysis47
pathway component: TransportCatalysis25
pathway component: Transport60
pathway component: Transport62
pathway component: Transport84
pathway component: Transport83
pathway component: Transport107
pathway component: Transport108
pathway component: Transport103
pathway component: Transport127
pathway component: Transport105
pathway component: Transport104
xref: Reference/PathWhiz PW000341
xref: Reference/SMPDB SMP0000132
organism: Homo sapiens

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Sodium/potassium ATPase
type: Complex
cellular location: Cell Membrane
component: Sodium/potassium-transporting ATPase subunit alpha-3
component: Sodium/potassium-transporting ATPase subunit alpha-2
component: ATPase, (Na+)/K+ transporting, beta 4 polypeptide
component: Sodium/potassium-transporting ATPase subunit gamma
component: Sodium/potassium-transporting ATPase subunit beta-3
component: Sodium/potassium-transporting ATPase subunit alpha-4
component: Sodium/potassium-transporting ATPase subunit beta-2
component: Sodium/potassium-transporting ATPase subunit beta-1
component: Sodium/potassium-transporting ATPase subunit alpha-1
name: SubPathwayOutput

Large neutral amino acids transporter small subunit 1
type: Protein
entity reference: Large neutral amino acids transporter small subunit 1

Transcription/Translation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway301
pathway component: SubPathwayInteraction301
xref: Reference/SMPDB SMP0000019
xref: Reference/PathWhiz PW000455
name: SubPathway

Reference/UniProt Q13733
type: UnificationXref
id: Q13733
db: UniProt

Reference/UniProt P55017
type: UnificationXref
id: P55017
db: UniProt

Sodium- and chloride-dependent transporter XTRP3
type: ProteinReference
xref: Reference/UniProt Q9NP91

Amiloride-sensitive sodium channel subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: Amiloride-sensitive sodium channel subunit alpha

Solute carrier family 22 member 6
type: ProteinReference
xref: Reference/UniProt Q4U2R8

4F2 cell-surface antigen heavy chain
type: ProteinReference
xref: Reference/UniProt P08195

Large Neutral Amino Acids
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Large Neutral Amino Acids

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/UniProt P48048
type: UnificationXref
id: P48048
db: UniProt

Y+L amino acid transporter 1
type: ProteinReference
xref: Reference/UniProt Q9UM01

Reference/ChemSpider 5653
type: UnificationXref
id: 5653
db: ChemSpider

Epithelial Sodium Channel
type: Complex
component: Amiloride-sensitive sodium channel subunit gamma
component: Amiloride-sensitive sodium channel subunit delta
component: Amiloride-sensitive sodium channel subunit beta
component: Amiloride-sensitive sodium channel subunit alpha

Amiloride-sensitive sodium channel subunit gamma
type: Protein
entity reference: Amiloride-sensitive sodium channel subunit gamma

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Transport84
type: Transport
participant stoichiometry: Compound/Generic50 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic50 Extracellular Space/Stoichiometry/1.0
right: Large Neutral Amino Acids
spontaneous: false
left: Large Neutral Amino Acids
name: Large Neutral Amino Acids (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport83
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: L-Amino acid
right: Sodium
spontaneous: false
left: Sodium
left: L-Amino acid
name: L-Amino acid (→), Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt Q01650
type: UnificationXref
id: Q01650
db: UniProt

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Compound/Generic32 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Anion
stoichiometric coefficient: 1.0

Organic Anion
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Organic Anion

Active Mineralocorticoid receptor (Homo sapiens)_Aldosterone
type: Complex
component stoichiometry: ProteinComplex/672 Nucleus/Stoichiometry/1.0
component stoichiometry: Compound/PW C000026 Nucleus/Stoichiometry/1.0
cellular location: Nucleus
component: Aldosterone
component: Active Mineralocorticoid receptor
name: SubPathwayInput

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/UniProt Q13621
type: UnificationXref
id: Q13621
db: UniProt

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Sodium/potassium-transporting ATPase subunit alpha-1
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-1

Reference/PathWhiz PW000341
type: UnificationXref
id: PW000341
db: PathWhiz

Compound/PW C000458 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Reference/UniProt P29972
type: UnificationXref
id: P29972
db: UniProt

Y+L amino acid transporter 2
type: ProteinReference
xref: Reference/UniProt Q92536

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

SubPathwayControl300
type: Interaction
name: SubPathway300Control
name: InhibitorySubPathwayControl
participant: Triamterene
participant: Epithelial Sodium Channel
participant: Triamterene inhibition of Epithelial Sodium Channel

Reference/UniProt P08235
type: UnificationXref
id: P08235
db: UniProt

Amiloride-sensitive sodium channel subunit delta
type: ProteinReference
xref: Reference/UniProt P51172
organism: Homo sapiens

Sodium/potassium-transporting ATPase subunit beta-1
type: ProteinReference
xref: Reference/UniProt P05026

Reference/CAS 52-90-4
type: UnificationXref
id: 52-90-4
db: CAS

Reference/UniProt P41181
type: UnificationXref
id: P41181
db: UniProt

Aquaporin-3
type: ProteinReference
xref: Reference/UniProt Q92482

Amiloride-sensitive sodium channel subunit beta
type: ProteinReference
xref: Reference/UniProt P51168
organism: Homo sapiens

Solute carrier family 12 member 3
type: ProteinReference
xref: Reference/UniProt P55017

Sodium/potassium-transporting ATPase subunit beta-2
type: ProteinReference
xref: Reference/UniProt P14415

Reference/UniProt B7ZKV8
type: UnificationXref
id: B7ZKV8
db: UniProt

Compound/Generic39 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Cation
stoichiometric coefficient: 1.0

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Excitatory amino acid transporter 3
type: ProteinReference
xref: Reference/UniProt P43005

Reference/UniProt P43005
type: UnificationXref
id: P43005
db: UniProt

Reference/HMDB HMDB0000492
type: UnificationXref
id: HMDB0000492
db: HMDB

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Compound/PW C000448 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17996
type: UnificationXref
id: CHEBI:17996
db: ChEBI

SubPathwayInteraction301
type: Interaction
name: SubPathway301Reaction
name: SubPathwayReaction
participant: Epithelial Sodium Channel
participant: Sodium/potassium ATPase
participant: Active Mineralocorticoid receptor (Homo sapiens)_Aldosterone

TransportCatalysis29
type: Catalysis
controller: Solute carrier family 12 member 6
controlled: Transport59
control type: ACTIVATION

Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Reference/SMPDB SMP0000019
type: UnificationXref
id: SMP0000019
db: SMPDB

Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

Compound/PW C000463 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000455
type: UnificationXref
id: PW000455
db: PathWhiz

ATP-sensitive inward rectifier potassium channel 1
type: ProteinReference
xref: Reference/UniProt P48048

TransportCatalysis24
type: Catalysis
controller: Chloride channel protein ClC-Ka
controlled: Transport54
control type: ACTIVATION

TransportCatalysis23
type: Catalysis
controller: Sodium/potassium ATPase
controlled: Transport53
control type: ACTIVATION

TransportCatalysis22
type: Catalysis
controller: Solute carrier family 12 member 3
controlled: Transport52
control type: ACTIVATION

Compound/Generic5 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Amino acid
stoichiometric coefficient: 1.0

Neutral and basic amino acid transport protein rBAT/B(0,+)-type amino acid transporter 1
type: Complex
component: Neutral and basic amino acid transport protein rBAT
component: B(0,+)-type amino acid transporter 1

Aquaporin-2
type: ProteinReference
xref: Reference/UniProt P41181

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

TransportCatalysis28
type: Catalysis
controller: Solute carrier family 12 member 1
controlled: Transport58
control type: ACTIVATION

Compound/PW C000200 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Urea
stoichiometric coefficient: 1.0

TransportCatalysis27
type: Catalysis
controller: Solute carrier family 22 member 6
controlled: Transport56
control type: ACTIVATION

Imino acids
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 26271

Reference/UniProt P54709
type: UnificationXref
id: P54709
db: UniProt

Reference/CAS 16887-00-6
type: UnificationXref
id: 16887-00-6
db: CAS

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

TransportCatalysis25
type: Catalysis
controller: Aquaporin-1
controlled: Transport55
control type: ACTIVATION

Reference/UniProt Q92482
type: UnificationXref
id: Q92482
db: UniProt

Urea
type: SmallMoleculeReference
xref: Reference/BioCyc UREA
xref: Reference/CAS 57-13-6
xref: Reference/KEGG Compound C00086
xref: Reference/HMDB HMDB0000294
xref: Reference/ChemSpider 1143
xref: Reference/PubChem-compound 1176
xref: Reference/ChEBI CHEBI 16199
chemical formula: CH4N2O
molecular weight: 60.032364
structure: ChemicalStructure/PW C000200

Reference/SMPDB SMP0000132
type: UnificationXref
id: SMP0000132
db: SMPDB

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

TransportCatalysis187
type: Catalysis
controller: Urea transporter 2
controlled: Transport105
control type: ACTIVATION

Aldosterone
type: SmallMolecule
cellular location: Nucleus
entity reference: Aldosterone

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: Protein
cellular location: Cell Membrane
entity reference: ATPase, (Na+)/K+ transporting, beta 4 polypeptide

Sodium/potassium-transporting ATPase subunit alpha-4
type: ProteinReference
xref: Reference/UniProt Q13733

Compound/PW C000374 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 2.0

Urea transporter 2
type: ProteinReference
xref: Reference/UniProt Q15849

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

Compound/Generic5 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Amino acid
stoichiometric coefficient: 1.0

Sodium/potassium-transporting ATPase subunit alpha-2
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-2

TransportCatalysis33
type: Catalysis
controller: Epithelial Sodium Channel
controlled: Transport62
control type: ACTIVATION

Reference/ChemSpider 5345
type: UnificationXref
id: 5345
db: ChemSpider

TransportCatalysis32
type: Catalysis
controller: Aquaporin-3
controlled: Transport55
control type: ACTIVATION

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Sodium/potassium-transporting ATPase subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P05023

Sodium-coupled neutral amino acid transporter 4
type: ProteinReference
xref: Reference/UniProt Q969I6

Reference/ChEBI CHEBI 16199
type: UnificationXref
id: CHEBI:16199
db: ChEBI

L-Amino acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Amino acid

Sodium/potassium-transporting ATPase subunit alpha-3
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-3

Large Neutral Amino Acids
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 33709

Reference/HMDB HMDB0000037
type: UnificationXref
id: HMDB0000037
db: HMDB

Solute carrier family 12 member 1
type: Protein
entity reference: Solute carrier family 12 member 1

TransportCatalysis30
type: Catalysis
controller: Solute carrier family 22 member 2
controlled: Transport60
control type: ACTIVATION

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Reference/UniProt Q969I6
type: UnificationXref
id: Q969I6
db: UniProt

Active Mineralocorticoid receptor
type: Complex
component stoichiometry: Protein/2032 Nucleus/Stoichiometry/2.0
cellular location: Nucleus
component: Mineralocorticoid receptor

Water
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Water

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Amiloride-sensitive sodium channel subunit alpha
type: ProteinReference
xref: Reference/UniProt P37088
organism: Homo sapiens

Solute carrier family 22 member 2
type: Protein
entity reference: Solute carrier family 22 member 2

B(0,+)-type amino acid transporter 1
type: ProteinReference
xref: Reference/UniProt P82251

Epithelial Sodium Channel
type: Complex
cellular location: Cell Membrane
component: Amiloride-sensitive sodium channel subunit alpha
component: Amiloride-sensitive sodium channel subunit gamma
component: Amiloride-sensitive sodium channel subunit delta
component: Amiloride-sensitive sodium channel subunit beta
name: SubPathwayOutput
name: SubPathwayInhibition

Neutral and basic amino acid transport protein rBAT
type: ProteinReference
xref: Reference/UniProt Q07837

Organic Cation
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 25697

Reference/UniProt P82251
type: UnificationXref
id: P82251
db: UniProt

Large neutral amino acids transporter small subunit 1
type: ProteinReference
xref: Reference/UniProt Q01650

Reference/ChemSpider 306
type: UnificationXref
id: 306
db: ChemSpider

Sodium/potassium-transporting ATPase subunit alpha-3
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-3

Sodium/potassium-transporting ATPase subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit beta-1

Organic Anion
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 25696

TransportCatalysis47
type: Catalysis
controller: Excitatory amino acid transporter 3
controlled: Transport83
control type: ACTIVATION

Mineralocorticoid receptor
type: ProteinReference
xref: Reference/UniProt P08235
organism: Homo sapiens

Amiloride-sensitive sodium channel subunit gamma
type: ProteinReference
xref: Reference/UniProt P51170
organism: Homo sapiens

Compound/Generic32 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Organic Anion
stoichiometric coefficient: 1.0

Sodium/potassium-transporting ATPase subunit beta-3
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit beta-3

Reference/UniProt Q15849
type: UnificationXref
id: Q15849
db: UniProt

Reference/UniProt Q9UHI5
type: UnificationXref
id: Q9UHI5
db: UniProt

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/CAS 52-39-1
type: UnificationXref
id: 52-39-1
db: CAS

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Reference/UniProt O15244
type: UnificationXref
id: O15244
db: UniProt

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Amiloride-sensitive sodium channel subunit beta
type: Protein
cellular location: Cell Membrane
entity reference: Amiloride-sensitive sodium channel subunit beta

Reference/PubChem-compound 1176
type: UnificationXref
id: 1176
db: PubChem-compound

Reference/HMDB HMDB0001940
type: UnificationXref
id: HMDB0001940
db: HMDB

Organic Cation
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Organic Cation

TransportCatalysis51
type: Catalysis
controller: SLC3A2/4F2hc Large neutral amino acids transporter small subunit 1
controlled: Transport84
control type: ACTIVATION

TransportCatalysis50
type: Catalysis
controller: SLC3A2/4F2hc Large neutral amino acids transporter small subunit 2
controlled: Transport84
control type: ACTIVATION

Compound/PW C000374 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Chloride ion
stoichiometric coefficient: 2.0

Amiloride-sensitive sodium channel subunit gamma
type: Protein
cellular location: Cell Membrane
entity reference: Amiloride-sensitive sodium channel subunit gamma

Hydrogen carbonate
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Hydrogen carbonate

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0000294
type: UnificationXref
id: HMDB0000294
db: HMDB

Triamterene
type: SmallMolecule
cellular location: Cytosol
entity reference: Triamterene

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

L-Cysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Cysteine

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/UniProt Q9UM01
type: UnificationXref
id: Q9UM01
db: UniProt

Sodium/potassium-transporting ATPase subunit alpha-2
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-2

TransportCatalysis4764
type: Catalysis
controller: ATP-sensitive inward rectifier potassium channel 1
controlled: Transport13687
control type: ACTIVATION

Reference/UniProt Q9UHW9
type: UnificationXref
id: Q9UHW9
db: UniProt

TransportCatalysis68
type: Catalysis
controller: Sodium- and chloride-dependent transporter XTRP3
controlled: Transport101
control type: ACTIVATION

Reference/KEGG Compound C00086
type: UnificationXref
id: C00086
db: KEGG Compound

Compound/Generic51 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Imino acids
stoichiometric coefficient: 1.0

Chloride ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Chloride ion

Reference/ChEBI CHEBI 27584
type: UnificationXref
id: CHEBI:27584
db: ChEBI

Reference/BioCyc CPD-4521
type: UnificationXref
id: CPD-4521
db: BioCyc

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: Protein
entity reference: ATPase, (Na+)/K+ transporting, beta 4 polypeptide

L-Cysteine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000574
xref: Reference/CAS 52-90-4
xref: Reference/KEGG Compound C00097
xref: Reference/BioCyc CYS
xref: Reference/ChemSpider 5653
xref: Reference/PubChem-compound 5862
xref: Reference/ChEBI CHEBI 17561
chemical formula: C3H7NO2S
molecular weight: 121.01975
structure: ChemicalStructure/PW C000448

L-Amino acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Amino acid

Chloride channel protein ClC-Ka
type: Protein
entity reference: Chloride channel protein ClC-Ka

TransportCatalysis78
type: Catalysis
controller: Solute carrier family 22 member 2
controlled: Transport112
control type: ACTIVATION

Reference/KEGG Compound C00097
type: UnificationXref
id: C00097
db: KEGG Compound

Compound/PW C001299 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Triamterene
stoichiometric coefficient: 1.0

TransportCatalysis71
type: Catalysis
controller: Sodium-coupled neutral amino acid transporter 4
controlled: Transport103
control type: ACTIVATION

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

TransportCatalysis73
type: Catalysis
controller: SLC3A2/4F2hc Y+L amino acid transporter 2
controlled: Transport104
control type: ACTIVATION

TransportCatalysis72
type: Catalysis
controller: SLC3A2/4F2hc Y+L amino acid transporter 1
controlled: Transport104
control type: ACTIVATION

Reference/UniProt P50993
type: UnificationXref
id: P50993
db: UniProt

Reference/UniProt P51168
type: UnificationXref
id: P51168
db: UniProt

Sodium/potassium-transporting ATPase subunit beta-2
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit beta-2

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Reference/UniProt P51172
type: UnificationXref
id: P51172
db: UniProt

Transport101
type: Transport
participant stoichiometry: Compound/Generic51 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic51 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000374 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Imino acids
right: Chloride ion
right: Sodium
spontaneous: false
left: Imino acids
left: Sodium
left: Chloride ion
name: Imino acids (→), Sodium (→), Chloride ion (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P51170
type: UnificationXref
id: P51170
db: UniProt

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Sodium/potassium-transporting ATPase subunit alpha-2
type: ProteinReference
xref: Reference/UniProt P50993

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Large neutral amino acids transporter small subunit 2
type: Protein
entity reference: Large neutral amino acids transporter small subunit 2

Sodium/potassium-transporting ATPase subunit alpha-4
type: Protein
cellular location: Cell Membrane
entity reference: Sodium/potassium-transporting ATPase subunit alpha-4

Solute carrier family 12 member 1
type: ProteinReference
xref: Reference/UniProt Q13621

Organic Cation
type: SmallMolecule
cellular location: Cytosol
entity reference: Organic Cation

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Protein/2032 Nucleus/Stoichiometry/2.0
type: Stoichiometry
physical entity: Mineralocorticoid receptor
stoichiometric coefficient: 2.0

Reference/PubChem-compound 5546
type: UnificationXref
id: 5546
db: PubChem-compound

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Transport13687
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Kidney, Cell, Cytosol to Homo sapiens, Kidney, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Compound/Generic50 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Large Neutral Amino Acids
stoichiometric coefficient: 1.0

Compound/PW C000200 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Urea
stoichiometric coefficient: 1.0

Aquaporin-1
type: Protein
entity reference: Aquaporin-1

Sodium/potassium-transporting ATPase subunit gamma
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit gamma

ChemicalStructure/PW C001299
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC(N)=C2N=C(C(N)=NC2=N1)C1=CC=CC=C1

Transport107
type: Transport
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
right: Hydrogen carbonate
spontaneous: false
left: Hydrogen carbonate
name: Hydrogen carbonate (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Mineralocorticoid receptor
type: Protein
cellular location: Nucleus
entity reference: Mineralocorticoid receptor

Reference/UniProt Q9NP91
type: UnificationXref
id: Q9NP91
db: UniProt

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C000463

Transport108
type: Transport
participant stoichiometry: Compound/PW C000463 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463 Extracellular Space/Stoichiometry/1.0
right: Hydrogen carbonate
spontaneous: false
left: Hydrogen carbonate
name: Hydrogen carbonate (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport103
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: L-Amino acid
spontaneous: false
left: L-Amino acid
left: Sodium
name: L-Amino acid (→), Sodium (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport105
type: Transport
participant stoichiometry: Compound/PW C000200 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000200 Cytosol/Stoichiometry/1.0
right: Urea
spontaneous: false
left: Urea
name: Urea (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Compound/PW C000457 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

Transport104
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic5 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
right: L-Amino acid
spontaneous: false
left: L-Amino acid
left: Sodium
name: L-Amino acid (→), Sodium (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT