Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Glutathione synthetase
type: Protein
cellular location: Cytoplasm
entity reference: Glutathione synthetase

Carbonic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003538
xref: Reference/BioCyc CARBON-DIOXIDE
xref: Reference/ChEBI CHEBI 28976
xref: Reference/PubChem-compound 22639876
xref: Reference/KEGG Compound C01353
xref: Reference/CAS 463-79-6
xref: Reference/ChemSpider 747
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C001916

Reference/ChemSpider 388356
type: UnificationXref
id: 388356
db: ChemSpider

Reference/ChEBI CHEBI 17345
type: UnificationXref
id: CHEBI:17345
db: ChEBI

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/UniProt Q9UI32
type: UnificationXref
id: Q9UI32
db: UniProt

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Compound/PW C000882 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Phosphoribosylamine
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/BioCyc CYS
type: UnificationXref
id: CYS
db: BioCyc

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

γ-Glutamylcysteine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00669
xref: Reference/PubChem-compound 123938
xref: Reference/HMDB HMDB0001049
xref: Reference/ChemSpider 110467
xref: Reference/ChEBI CHEBI 17515
xref: Reference/CAS 636-58-8
xref: Reference/BioCyc L-GAMMA-GLUTAMYLCYSTEINE
chemical formula: C8H14N2O5S
molecular weight: 250.06235
structure: ChemicalStructure/PW C000826

Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

L-Aspartic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Aspartic acid

Glutathione reductase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Glutathione reductase, mitochondrial

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Succinic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Succinic acid

Reference/HMDB HMDB0003362
type: UnificationXref
id: HMDB0003362
db: HMDB

Reference/HMDB HMDB0001062
type: UnificationXref
id: HMDB0001062
db: HMDB

Reference/ChemSpider 50
type: UnificationXref
id: 50
db: ChemSpider

Compound/PW C001196 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Xanthylic acid
stoichiometric coefficient: 1.0

Reference/CAS 85-32-5
type: UnificationXref
id: 85-32-5
db: CAS

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/ChemSpider 145043
type: UnificationXref
id: 145043
db: ChemSpider

Reference/BioCyc OXALACETIC ACID
type: UnificationXref
id: OXALACETIC_ACID
db: BioCyc

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

tRNA(Glu)
type: Rna
cellular location: Cytoplasm
entity reference: tRNA(Glu)

Compound/PW C000414 Cytoplasm/Stoichiometry/3.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 3.0

Protein/560 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: GMP synthase [glutamine-hydrolyzing]
stoichiometric coefficient: 2.0

Reference/PathWhiz PW000052
type: UnificationXref
id: PW000052
db: PathWhiz

Reference/ChEBI CHEBI 17111
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Reference/ChEBI CHEBI 16265
type: UnificationXref
id: CHEBI:16265
db: ChEBI

N-Acetyl-D-Glucosamine 6-Phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15784
xref: Reference/ChemSpider 389821
xref: Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-6-P
xref: Reference/HMDB HMDB0001062
xref: Reference/KEGG Compound C00357
xref: Reference/CAS 102029-88-9
xref: Reference/PubChem-compound 440996
chemical formula: C8H16NO9P
molecular weight: 301.05627
structure: ChemicalStructure/PW C000837

Aspartate aminotransferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P00505
organism: Homo sapiens

Alanine aminotransferase 1
type: Protein
cellular location: Cytoplasm
entity reference: Alanine aminotransferase 1

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P30038
organism: Homo sapiens

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/PubChem-compound 165491
type: UnificationXref
id: 165491
db: PubChem-compound

SubPathwayInteraction140
type: Interaction
name: SubPathway140Reaction
name: SubPathwayReaction
participant: L-Glutamic acid

Reference/PathWhiz PW000043
type: UnificationXref
id: PW000043
db: PathWhiz

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Reference/ChemSpider 5745
type: UnificationXref
id: 5745
db: ChemSpider

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Compound/PW C000915 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Nicotinic acid adenine dinucleotide
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00334
type: UnificationXref
id: C00334
db: KEGG Compound

Compound/PW C001034 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 2.0

Reference/BioCyc L-ASPARTATE
type: UnificationXref
id: L-ASPARTATE
db: BioCyc

Reference/PathWhiz PW000162
type: UnificationXref
id: PW000162
db: PathWhiz

Reference/ChEBI CHEBI 17561
type: UnificationXref
id: CHEBI:17561
db: ChEBI

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/PathWhiz PW000160
type: UnificationXref
id: PW000160
db: PathWhiz

Reference/ChemSpider 950
type: UnificationXref
id: 950
db: ChemSpider

Reference/CAS 7540-64-9
type: UnificationXref
id: 7540-64-9
db: CAS

Carbon dioxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Carbon dioxide

ChemicalStructure/PW C001080
type: ChemicalStructure
structure format: SMILES

L-Glutamic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Glutamic acid

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

RNA/41/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA(Gln)
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18304
type: UnificationXref
id: CHEBI:18304
db: ChEBI

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine monophosphate

Reference/ChemSpider 5735
type: UnificationXref
id: 5735
db: ChemSpider

Compound/PW C000143 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00461
type: UnificationXref
id: C00461
db: KEGG Compound

Reference/ChemSpider 945
type: UnificationXref
id: 945
db: ChemSpider

Compound/PW C000414 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 2.0

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Protein/795 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Alanine aminotransferase 1
stoichiometric coefficient: 2.0

Compound/PW C000148 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxalacetic acid
stoichiometric coefficient: 1.0

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/HMDB HMDB0001096
type: UnificationXref
id: HMDB0001096
db: HMDB

Reference/KEGG Compound C00119
type: UnificationXref
id: C00119
db: KEGG Compound

Reference/ChEBI CHEBI 17029
type: UnificationXref
id: CHEBI:17029
db: ChEBI

Compound/PW C000032/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Probable glutamate--tRNA ligase, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Probable glutamate--tRNA ligase, mitochondrial

Carbamoyl phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 278
xref: Reference/BioCyc CARBAMOYL-P
xref: Reference/ChemSpider 272
xref: Reference/HMDB HMDB0001096
xref: Reference/CAS 590-55-6
xref: Reference/KEGG Compound C00169
xref: Reference/ChEBI CHEBI 17672
chemical formula: CH4NO5P
molecular weight: 140.98271
structure: ChemicalStructure/PW C000862

Reference/KEGG Compound C00232
type: UnificationXref
id: C00232
db: KEGG Compound

L-Glutamic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamic acid
name: SubPathwayOutput
name: SubPathwayInput

Reference/KEGG Compound C00352
type: UnificationXref
id: C00352
db: KEGG Compound

Reference/PubChem-compound 124886
type: UnificationXref
id: 124886
db: PubChem-compound

Reference/KEGG Compound C00357
type: UnificationXref
id: C00357
db: KEGG Compound

Amidophosphoribosyltransferase
type: Protein
cellular location: Cytoplasm
entity reference: Amidophosphoribosyltransferase

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/UniProt Q99259
type: UnificationXref
id: Q99259
db: UniProt

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

Compound/PW C000914 Cytoplasm/Stoichiometry/3.0
type: Stoichiometry
physical entity: Adenosine diphosphate ribose
stoichiometric coefficient: 3.0

Fructose 6-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Fructose 6-phosphate

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

CAD protein
type: Complex
component stoichiometry: Protein/2335 Cytoplasm/Stoichiometry/6.0
cellular location: Cytoplasm
component: CAD protein

Reference/ChemSpider 1159
type: UnificationXref
id: 1159
db: ChemSpider

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/CAS 3616-42-0
type: UnificationXref
id: 3616-42-0
db: CAS

Reference/KEGG Compound C00127
type: UnificationXref
id: C00127
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Compound/PW C000500/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/BioCyc L-ALPHA-ALANINE
type: UnificationXref
id: L-ALPHA-ALANINE
db: BioCyc

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Carbonic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Carbonic acid

Reference/CAS 56-41-7
type: UnificationXref
id: 56-41-7
db: CAS

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Oxidized glutathione
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003337
xref: Reference/PubChem-compound 5255796
xref: Reference/ChemSpider 950
xref: Reference/KEGG Compound C00127
xref: Reference/BioCyc OXIDIZED-GLUTATHIONE
xref: Reference/CAS 27025-41-8
xref: Reference/ChEBI CHEBI 17858
chemical formula: C20H32N6O12S2
molecular weight: 612.152
structure: ChemicalStructure/PW C001847

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChemSpider 1031
type: UnificationXref
id: 1031
db: ChemSpider

Reference/PubChem-compound 73323
type: UnificationXref
id: 73323
db: PubChem-compound

Protein/191 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glutathione reductase, mitochondrial
stoichiometric coefficient: 2.0

Compound/PW C000969 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosamine 6-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 66054
type: UnificationXref
id: 66054
db: ChemSpider

Carbamoyl-phosphate synthase [ammonia], mitochondrial
type: ProteinReference
xref: Reference/UniProt P31327
organism: Homo sapiens

5-Phosphoribosylamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001128
xref: Reference/ChEBI CHEBI 37737
xref: Reference/BioCyc 5-P-BETA-D-RIBOSYL-AMINE
xref: Reference/ChemSpider 388939
xref: Reference/KEGG Compound C03090
xref: Reference/PubChem-compound 439905
chemical formula: C5H12NO7P
molecular weight: 229.03514
structure: ChemicalStructure/PW C000882

Glutamate dehydrogenase 1, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Glutamate dehydrogenase 1, mitochondrial

Reference/INSDC 945257
type: UnificationXref
id: 945257
db: INSDC

Carbamoyl phosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Carbamoyl phosphate

SubPathwayInteraction137
type: Interaction
name: SubPathwayReaction
name: SubPathway137Reaction
participant: 1-Pyrroline-5-carboxylic acid

SubPathwayInteraction139
type: Interaction
name: SubPathway139Reaction
name: SubPathwayReaction
participant: L-Glutamic acid

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

SubPathwayInteraction138
type: Interaction
name: SubPathway138Reaction
name: SubPathwayReaction
participant: L-Glutamic acid

Reference/PubChem-compound 44367445
type: UnificationXref
id: 44367445
db: PubChem-compound

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Glutamate--cysteine ligase catalytic subunit
type: Protein
cellular location: Cytoplasm
entity reference: Glutamate--cysteine ligase catalytic subunit

Reference/PubChem-compound 7339
type: UnificationXref
id: 7339
db: PubChem-compound

Compound/PW C000134 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Protein/492 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate--cysteine ligase regulatory subunit
stoichiometric coefficient: 1.0

Reference/BioCyc FRUCTOSE-6P
type: UnificationXref
id: FRUCTOSE-6P
db: BioCyc

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Compound/PW C000080 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Glucosamine 6-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 3616-42-0
xref: Reference/ChemSpider 388356
xref: Reference/ChEBI CHEBI 15873
xref: Reference/KEGG Compound C00352
xref: Reference/BioCyc D-GLUCOSAMINE-6-P
xref: Reference/PubChem-compound 439217
xref: Reference/HMDB HMDB0001254
chemical formula: C6H14NO8P
molecular weight: 259.04572
structure: ChemicalStructure/PW C000969

Succinate-semialdehyde dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P51649
organism: Homo sapiens

Reference/UniProt A8YXX4
type: UnificationXref
id: A8YXX4
db: UniProt

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Guanosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine monophosphate

4-aminobutyrate aminotransferase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P80404
organism: Homo sapiens

Reference/BioCyc D-GLUCOSAMINE-6-P
type: UnificationXref
id: D-GLUCOSAMINE-6-P
db: BioCyc

Pyruvic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyruvic acid

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

ChemicalStructure/PW C000915
type: ChemicalStructure
structure format: SMILES

Carbamoyl phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Carbamoyl phosphate
name: SubPathwayInput

Succinic acid semialdehyde
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001259
xref: Reference/BioCyc SUCC-S-ALD
xref: Reference/ChemSpider 1080
xref: Reference/CAS 692-29-5
xref: Reference/KEGG Compound C00232
xref: Reference/PubChem-compound 1112
xref: Reference/ChEBI CHEBI 16265
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000972

Reference/KEGG Compound C00144
type: UnificationXref
id: C00144
db: KEGG Compound

Reference/KEGG Compound C01353
type: UnificationXref
id: C01353
db: KEGG Compound

Reference/KEGG Compound C00022
type: UnificationXref
id: C00022
db: KEGG Compound

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/ChemSpider 5653
type: UnificationXref
id: 5653
db: ChemSpider

ChemicalStructure/PW C000914
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00026
type: UnificationXref
id: C00026
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/ChemSpider 62713
type: UnificationXref
id: 62713
db: ChemSpider

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

N-Acetyl-D-Glucosamine 6-Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: N-Acetyl-D-Glucosamine 6-Phosphate

5-Phosphoribosylamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5-Phosphoribosylamine
name: SubPathwayInput

Glutamate--cysteine ligase regulatory subunit
type: ProteinReference
xref: Reference/UniProt P48507
organism: Homo sapiens

Glutamate--cysteine ligase catalytic subunit
type: ProteinReference
xref: Reference/UniProt P48506
organism: Homo sapiens

6.3.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: L-Glutamine
right: Adenosine diphosphate
right: Phosphate
spontaneous: false
EC number: 6.3.1.2
left: Adenosine triphosphate
left: L-Glutamic acid
left: Ammonia
name: Adenosine triphosphate + Ammonia + L-Glutamic acid → Adenosine diphosphate + L-Glutamine + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc OXIDIZED-GLUTATHIONE
type: UnificationXref
id: OXIDIZED-GLUTATHIONE
db: BioCyc

Reaction39
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000972 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000071 Cytoplasm/Stoichiometry/1.0
right: L-Glutamic acid
right: Succinic acid semialdehyde
spontaneous: false
left: Oxoglutaric acid
left: γ-Aminobutyric acid
name: Oxoglutaric acid + γ-Aminobutyric acid ↔ L-Glutamic acid + Succinic acid semialdehyde
conversion direction: REVERSIBLE

1.4.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
right: Ammonia
right: Oxoglutaric acid
right: NADH
spontaneous: false
EC number: 1.4.1.3
left: L-Glutamic acid
left: NAD
left: Water
name: L-Glutamic acid + NAD + Water → Ammonia + NADH + Oxoglutaric acid
conversion direction: LEFT_TO_RIGHT

Glutamine--tRNA ligase
type: ProteinReference
xref: Reference/UniProt P47897

Reference/CAS 52-90-4
type: UnificationXref
id: 52-90-4
db: CAS

Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyruvic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00037
type: UnificationXref
id: C00037
db: KEGG Compound

Reference/KEGG Compound C00036
type: UnificationXref
id: C00036
db: KEGG Compound

Glutamate decarboxylase 1
type: ProteinReference
xref: Reference/UniProt Q99259
organism: Homo sapiens

Reference/CAS 328-50-7
type: UnificationXref
id: 328-50-7
db: CAS

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

Reference/KEGG Compound C00041
type: UnificationXref
id: C00041
db: KEGG Compound

Reference/UniProt Q5JPH6
type: UnificationXref
id: Q5JPH6
db: UniProt

Reference/ChemSpider 110467
type: UnificationXref
id: 110467
db: ChemSpider

Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Adenosine diphosphate

Reference/ChEBI CHEBI 29175
type: UnificationXref
id: CHEBI:29175
db: ChEBI

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

Compound/PW C000914 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate ribose
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/BioCyc CARBON-DIOXIDE
type: UnificationXref
id: CARBON-DIOXIDE
db: BioCyc

L-Glutamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamine

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

2.4.2.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000190 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000882 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
right: Water
right: Phosphoribosyl pyrophosphate
right: L-Glutamine
spontaneous: false
EC number: 2.4.2.14
left: 5-Phosphoribosylamine
left: L-Glutamic acid
left: Pyrophosphate
name: 5-Phosphoribosylamine + L-Glutamic acid + Pyrophosphate ↔ L-Glutamine + Phosphoribosyl pyrophosphate + Water
conversion direction: REVERSIBLE

Compound/PW C001916 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbonic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00049
type: UnificationXref
id: C00049
db: KEGG Compound

3.5.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000500 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
right: L-Glutamic acid
right: Ammonia
spontaneous: false
EC number: 3.5.1.2
left: L-Glutamine
left: Water
name: L-Glutamine + Water → Ammonia + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00169
type: UnificationXref
id: C00169
db: KEGG Compound

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

1.2.1.88
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001003 Mitochondrion/Stoichiometry/1.0
right: L-Glutamic acid
right: NADH
spontaneous: false
EC number: 1.2.1.88
left: NAD
left: Water
left: 1-Pyrroline-5-carboxylic acid
name: 1-Pyrroline-5-carboxylic acid + NAD + 2 Water ↔ L-Glutamic acid + NADH
conversion direction: REVERSIBLE

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 7062
type: UnificationXref
id: 7062
db: ChemSpider

Protein/210 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
stoichiometric coefficient: 4.0

Reference/BioCyc ADENOSINE DIPHOSPHATE RIBOSE
type: UnificationXref
id: ADENOSINE_DIPHOSPHATE_RIBOSE
db: BioCyc

Alanine aminotransferase 1
type: ProteinReference
xref: Reference/UniProt P24298
organism: Homo sapiens

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003538
type: UnificationXref
id: HMDB0003538
db: HMDB

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reference/KEGG Compound C00051
type: UnificationXref
id: C00051
db: KEGG Compound

Protein/2335 Cytoplasm/Stoichiometry/6.0
type: Stoichiometry
physical entity: CAD protein
stoichiometric coefficient: 6.0

Reference/ChemSpider 389821
type: UnificationXref
id: 389821
db: ChemSpider

Oxoglutaric acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxoglutaric acid

Reference/ChemSpider 399508
type: UnificationXref
id: 399508
db: ChemSpider

ChemicalStructure/PW C000148
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC(=O)C(O)=O

Amidophosphoribosyltransferase
type: ProteinReference
xref: Reference/UniProt Q06203
organism: Homo sapiens

Reference/UniProt Q06203
type: UnificationXref
id: Q06203
db: UniProt

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Chitin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17029
xref: Reference/ChemSpider 399508
xref: Reference/HMDB HMDB0003362
xref: Reference/CAS 1398-61-4
xref: Reference/KEGG Compound C00461
xref: Reference/PubChem-compound 21252321
xref: Reference/BioCyc 14-N-ACETYL-BETA-D-GLUCOSAMINYLN1
chemical formula: C24H41N3O16
molecular weight: 627.24866
structure: ChemicalStructure/PW C001858

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

NAD
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NAD

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 123938
type: UnificationXref
id: 123938
db: PubChem-compound

Reference/UniProt P51649
type: UnificationXref
id: P51649
db: UniProt

Reference/HMDB HMDB0001128
type: UnificationXref
id: HMDB0001128
db: HMDB

Protein/2614 Cytoplasm/Stoichiometry/10.0
type: Stoichiometry
physical entity: Glutamine synthetase
stoichiometric coefficient: 10.0

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

ChemicalStructure/PW C001003
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1CCC=N1

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: Reference/UniProt P49915
organism: Homo sapiens

L-Cysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Cysteine

Reference/CAS 590-55-6
type: UnificationXref
id: 590-55-6
db: CAS

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

Glutamate dehydrogenase 1, mitochondrial
type: Complex
component stoichiometry: Protein/658 Mitochondrion/Stoichiometry/6.0
cellular location: Mitochondrion
component: Glutamate dehydrogenase 1, mitochondrial

Reference/BioCyc 14-N-ACETYL-BETA-D-GLUCOSAMINYLN1
type: UnificationXref
id: 14-N-ACETYL-BETA-D-GLUCOSAMINYLN1
db: BioCyc

Reference/ChEBI CHEBI 29157
type: UnificationXref
id: CHEBI:29157
db: ChEBI

1.8.1.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000143 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001847 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080 Mitochondrion/Stoichiometry/2.0
right: Glutathione
right: NADP
spontaneous: false
EC number: 1.8.1.7
left: Oxidized glutathione
left: NADPH
name: NADPH + Oxidized glutathione ↔ 2 Glutathione + NADP
conversion direction: REVERSIBLE

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/UniProt Q06210
type: UnificationXref
id: Q06210
db: UniProt

Reference/ChEBI CHEBI 17053
type: UnificationXref
id: CHEBI:17053
db: ChEBI

Reference/CAS 56-40-6
type: UnificationXref
id: 56-40-6
db: CAS

Reference/BioCyc XANTHOSINE-5-PHOSPHATE
type: UnificationXref
id: XANTHOSINE-5-PHOSPHATE
db: BioCyc

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Reference/UniProt P24298
type: UnificationXref
id: P24298
db: UniProt

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

2.6.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000105 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000164 Cytoplasm/Stoichiometry/1.0
right: Pyruvic acid
right: L-Glutamic acid
spontaneous: false
EC number: 2.6.1.2
left: L-Alanine
left: Oxoglutaric acid
name: L-Alanine + Oxoglutaric acid ↔ L-Glutamic acid + Pyruvic acid
conversion direction: REVERSIBLE

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
type: ProteinReference
xref: Reference/UniProt Q06210
organism: Homo sapiens

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

ChemicalStructure/PW C000164
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)C(O)=O

Reference/HMDB HMDB0001259
type: UnificationXref
id: HMDB0001259
db: HMDB

Compound/PW C000500 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000280
type: UnificationXref
id: HMDB0000280
db: HMDB

Ammonia
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Ammonia

Reference/HMDB HMDB0000161
type: UnificationXref
id: HMDB0000161
db: HMDB

Reference/HMDB HMDB0001254
type: UnificationXref
id: HMDB0001254
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/UniProt P00390
type: UnificationXref
id: P00390
db: UniProt

RNA/8 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA(Glu)
stoichiometric coefficient: 1.0

L-Alanine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00041
xref: Reference/ChemSpider 5735
xref: Reference/ChEBI CHEBI 16977
xref: Reference/BioCyc L-ALPHA-ALANINE
xref: Reference/HMDB HMDB0000161
xref: Reference/CAS 56-41-7
xref: Reference/PubChem-compound 5950
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000105

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Compound/PW C001080 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine monophosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/CAS 636-58-8
type: UnificationXref
id: 636-58-8
db: CAS

Compound/PW C000105 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Alanine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/CAS 6450-77-7
type: UnificationXref
id: 6450-77-7
db: CAS

Reference/ChemSpider 730
type: UnificationXref
id: 730
db: ChemSpider

Reference/KEGG Compound C00085
type: UnificationXref
id: C00085
db: KEGG Compound

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Glutathione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glutathione

Probable glutamate--tRNA ligase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q5JPH6
organism: Homo sapiens

Glutamine synthetase
type: ProteinReference
xref: Reference/UniProt A8YXX4
organism: Homo sapiens

L-Glutamine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Glutamine

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Glutamine--fructose-6-phosphate aminotransferase
type: Complex
component stoichiometry: Protein/210 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

Reference/BioCyc PYRUVATE
type: UnificationXref
id: PYRUVATE
db: BioCyc

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Compound/PW C001316 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Glutaminase liver isoform, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9UI32
organism: Homo sapiens

Reference/KEGG Compound C04322
type: UnificationXref
id: C04322
db: KEGG Compound

4-aminobutyrate aminotransferase, mitochondrial
type: Complex
component stoichiometry: Protein/242 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: 4-aminobutyrate aminotransferase, mitochondrial

NADP
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADP

Reference/HMDB HMDB0003337
type: UnificationXref
id: HMDB0003337
db: HMDB

ChemicalStructure/PW C001196
type: ChemicalStructure
structure format: SMILES

L-Aspartic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44367445
xref: Reference/ChemSpider 5745
xref: Reference/ChEBI CHEBI 17053
xref: Reference/HMDB HMDB0000191
xref: Reference/CAS 56-84-8
xref: Reference/KEGG Compound C00049
xref: Reference/BioCyc L-ASPARTATE
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C000123

Reference/PubChem-compound 439905
type: UnificationXref
id: 439905
db: PubChem-compound

Succinate-semialdehyde dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/243 Mitochondrion/Stoichiometry/4.0
cellular location: Mitochondrion
component: Succinate-semialdehyde dehydrogenase, mitochondrial

Reference/HMDB HMDB0001397
type: UnificationXref
id: HMDB0001397
db: HMDB

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

L-Cysteine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000574
xref: Reference/CAS 52-90-4
xref: Reference/KEGG Compound C00097
xref: Reference/BioCyc CYS
xref: Reference/ChemSpider 5653
xref: Reference/PubChem-compound 5862
xref: Reference/ChEBI CHEBI 17561
chemical formula: C3H7NO2S
molecular weight: 121.01975
structure: ChemicalStructure/PW C000448

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00097
type: UnificationXref
id: C00097
db: KEGG Compound

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/HMDB HMDB0001049
type: UnificationXref
id: HMDB0001049
db: HMDB

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Adenosine diphosphate ribose
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate ribose

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Reference/BioCyc 4-AMINO-BUTYRATE
type: UnificationXref
id: 4-AMINO-BUTYRATE
db: BioCyc

ChemicalStructure/PW C000079
type: ChemicalStructure
structure format: SMILES

Compound/PW C000095 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000078
type: ChemicalStructure
structure format: SMILES
structure data: NCC(O)=O

ChemicalStructure/PW C000190
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388939
type: UnificationXref
id: 388939
db: ChemSpider

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/151 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

Reference/HMDB HMDB0000191
type: UnificationXref
id: HMDB0000191
db: HMDB

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

ChemicalStructure/PW C000071
type: ChemicalStructure
structure format: SMILES
structure data: NCCCC(O)=O

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

N-Acetyl-D-Glucosamine 6-Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: N-Acetyl-D-Glucosamine 6-Phosphate

Compound/PW C000079 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 6-phosphate
stoichiometric coefficient: 1.0

NADPH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADPH

Glutamine synthetase
type: Complex
component stoichiometry: Protein/2614 Cytoplasm/Stoichiometry/10.0
cellular location: Cytoplasm
component: Glutamine synthetase

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Protein/50 Cell Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glucosamine 6-phosphate N-acetyltransferase
stoichiometric coefficient: 2.0

Glutamate dehydrogenase 1, mitochondrial
type: ProteinReference
xref: Reference/UniProt P00367
organism: Homo sapiens

Reference/CAS 56-84-8
type: UnificationXref
id: 56-84-8
db: CAS

Reference/ChemSpider 747
type: UnificationXref
id: 747
db: ChemSpider

Reference/CAS 102029-88-9
type: UnificationXref
id: 102029-88-9
db: CAS

Reference/PubChem-compound 970
type: UnificationXref
id: 970
db: PubChem-compound

Reference/BioCyc L-GAMMA-GLUTAMYLCYSTEINE
type: UnificationXref
id: L-GAMMA-GLUTAMYLCYSTEINE
db: BioCyc

Reference/HMDB HMDB0001179
type: UnificationXref
id: HMDB0001179
db: HMDB

Reference/HMDB HMDB0001178
type: UnificationXref
id: HMDB0001178
db: HMDB

Compound/PW C000080 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000080
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc 5-P-BETA-D-RIBOSYL-AMINE
type: UnificationXref
id: 5-P-BETA-D-RIBOSYL-AMINE
db: BioCyc

RNA/42/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutaminyl-tRNA(Gln)
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NAD

Compound/PW C000837 Cytoplasm/Stoichiometry/3.0
type: Stoichiometry
physical entity: N-Acetyl-D-Glucosamine 6-Phosphate
stoichiometric coefficient: 3.0

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Oxalacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000223
xref: Reference/CAS 328-42-7
xref: Reference/ChEBI CHEBI 30744
xref: Reference/BioCyc OXALACETIC ACID
xref: Reference/ChemSpider 945
xref: Reference/PubChem-compound 970
xref: Reference/KEGG Compound C00036
chemical formula: C4H4O5
molecular weight: 132.00587
structure: ChemicalStructure/PW C000148

Compound/PW C000972 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid semialdehyde
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000448
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CS)C(O)=O

Protein/243 Mitochondrion/Stoichiometry/4.0
type: Stoichiometry
physical entity: Succinate-semialdehyde dehydrogenase, mitochondrial
stoichiometric coefficient: 4.0

Carbamoyl-phosphate synthase [ammonia], mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Carbamoyl-phosphate synthase [ammonia], mitochondrial

1-Pyrroline-5-carboxylic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 1159
xref: Reference/HMDB HMDB0001301
xref: Reference/ChEBI CHEBI 1372
xref: Reference/CAS 2906-39-0
xref: Reference/BioCyc l-delta(1)-pyrroline 5-carboxylate
xref: Reference/KEGG Compound C04322
xref: Reference/PubChem-compound 1196
chemical formula: C5H7NO2
molecular weight: 113.047676
structure: ChemicalStructure/PW C001003

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

2.6.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000079 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000969 Cytoplasm/Stoichiometry/1.0
right: Glucosamine 6-phosphate
right: L-Glutamic acid
spontaneous: false
EC number: 2.6.1.16
left: L-Glutamine
left: Fructose 6-phosphate
name: Fructose 6-phosphate + L-Glutamine → Glucosamine 6-phosphate + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 21252321
type: UnificationXref
id: 21252321
db: PubChem-compound

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

ReactionCatalysis26
type: Catalysis
controller: Glutathione reductase, mitochondrial
controlled: 1.8.1.7
control type: ACTIVATION

Reference/PubChem-compound 119
type: UnificationXref
id: 119
db: PubChem-compound

1.2.1.24
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000174 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000972 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
right: Succinic acid
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.2.1.24
left: NAD
left: Water
left: Succinic acid semialdehyde
name: NAD + Succinic acid semialdehyde + Water → Hydrogen Ion + NADH + Succinic acid
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Chitin
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Chitin

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Compound/PW C000862 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbamoyl phosphate
stoichiometric coefficient: 1.0

Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Reference/UniProt P27708
type: UnificationXref
id: P27708
db: UniProt

Histidine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway138
pathway component: SubPathwayInteraction138
xref: Reference/PathWhiz PW000043
xref: Reference/SMPDB SMP0000044
name: SubPathway

Ammonia
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Ammonia

Reference/CAS 643-13-0
type: UnificationXref
id: 643-13-0
db: CAS

GMP synthase [glutamine-hydrolyzing]
type: Complex
component stoichiometry: Protein/560 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: GMP synthase [glutamine-hydrolyzing]

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/CAS 328-42-7
type: UnificationXref
id: 328-42-7
db: CAS

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/PubChem-compound 51
type: UnificationXref
id: 51
db: PubChem-compound

Reference/ChEBI CHEBI 37737
type: UnificationXref
id: CHEBI:37737
db: ChEBI

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/UniProt P00367
type: UnificationXref
id: P00367
db: UniProt

Succinic acid semialdehyde
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Succinic acid semialdehyde

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Compound/PW C001420 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Pyruvic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 1060
xref: Reference/HMDB HMDB0000243
xref: Reference/CAS 127-17-3
xref: Reference/BioCyc PYRUVATE
xref: Reference/KEGG Compound C00022
xref: Reference/ChEBI CHEBI 32816
xref: Reference/ChemSpider 1031
chemical formula: C3H4O3
molecular weight: 88.016045
structure: ChemicalStructure/PW C000164

GMP synthase [glutamine-hydrolyzing]
type: Protein
cellular location: Cytoplasm
entity reference: GMP synthase [glutamine-hydrolyzing]

Pyrimidine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway855
pathway component: SubPathwayInteraction855
xref: Reference/SMPDB SMP0000046
xref: Reference/PathWhiz PW000160
name: SubPathway

ReactionCatalysis38
type: Catalysis
controller: Glutamate dehydrogenase 1, mitochondrial
controlled: 1.4.1.3
control type: ACTIVATION

ReactionCatalysis39
type: Catalysis
controller: 4-aminobutyrate aminotransferase, mitochondrial
controlled: Reaction39
control type: ACTIVATION

Glycine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glycine

Glutathione reductase, mitochondrial
type: Complex
component stoichiometry: Protein/191 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Glutathione reductase, mitochondrial

ReactionCatalysis37
type: Catalysis
controller: Glutamine synthetase
controlled: 6.3.1.2
control type: ACTIVATION

Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-6-P
type: UnificationXref
id: N-ACETYL-D-GLUCOSAMINE-6-P
db: BioCyc

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

SubPathwayInteraction855
type: Interaction
name: SubPathwayReaction
name: SubPathway855Reaction
participant: Carbamoyl phosphate

SubPathwayInteraction856
type: Interaction
name: SubPathway856Reaction
name: SubPathwayReaction
participant: 5-Phosphoribosylamine

Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Phosphoribosyl pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphoribosyl pyrophosphate

Glutamate decarboxylase 1
type: Complex
component stoichiometry: Protein/667 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Glutamate decarboxylase 1

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

SubPathwayInteraction858
type: Interaction
name: SubPathwayReaction
name: SubPathway858Reaction
participant: γ-Aminobutyric acid

N-acetyl-D-glucosamine kinase
type: ProteinReference
xref: Reference/UniProt Q9UJ70
organism: Homo sapiens

Reference/UniProt P48637
type: UnificationXref
id: P48637
db: UniProt

Purine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway856
pathway component: SubPathwayInteraction856
xref: Reference/SMPDB SMP0000050
xref: Reference/PathWhiz PW000052
name: SubPathway

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Adenosine monophosphate
type: SmallMolecule
entity reference: Adenosine monophosphate

Oxoglutaric acid
type: SmallMoleculeReference
xref: Reference/CAS 328-50-7
xref: Reference/PubChem-compound 51
xref: Reference/BioCyc 2-KETOGLUTARATE
xref: Reference/HMDB HMDB0000208
xref: Reference/ChEBI CHEBI 30915
xref: Reference/KEGG Compound C00026
xref: Reference/ChemSpider 50
chemical formula: C5H6O5
molecular weight: 146.02153
structure: ChemicalStructure/PW C000134

Reference/ChemSpider 272
type: UnificationXref
id: 272
db: ChemSpider

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen Ion

4-aminobutyrate aminotransferase, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: 4-aminobutyrate aminotransferase, mitochondrial

Urea Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway140
pathway component: SubPathwayInteraction140
xref: Reference/SMPDB SMP0000059
xref: Reference/PathWhiz PW000162
name: SubPathway

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Glucosamine 6-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glucosamine 6-phosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

ReactionCatalysis41
type: Catalysis
controller: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
controlled: 1.2.1.88
control type: ACTIVATION

Glutathione synthetase
type: ProteinReference
xref: Reference/UniProt P48637
organism: Homo sapiens

Reference/PubChem-compound 5862
type: UnificationXref
id: 5862
db: PubChem-compound

ReactionCatalysis43
type: Catalysis
controller: Glutaminase liver isoform, mitochondrial
controlled: 3.5.1.2
control type: ACTIVATION

ReactionCatalysis44
type: Catalysis
controller: Amidophosphoribosyltransferase
controlled: 2.4.2.14
control type: ACTIVATION

Compound/PW C000862 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbamoyl phosphate
stoichiometric coefficient: 1.0

tRNA(Gln)
type: Rna
entity reference: tRNA(Gln)

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Adenosine triphosphate

L-Glutaminyl-tRNA(Gln)
type: Rna
entity reference: L-Glutaminyl-tRNA(Gln)

Nicotinic acid adenine dinucleotide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Nicotinic acid adenine dinucleotide

Reference/ChEBI CHEBI 15946
type: UnificationXref
id: CHEBI:15946
db: ChEBI

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

ReactionCatalysis2202
type: Catalysis
controller: N-acetyl-D-glucosamine kinase
controlled: 2.7.1.59
control type: ACTIVATION

ReactionCatalysis2201
type: Catalysis
controller: Glutamine--tRNA ligase
controlled: 6.1.1.18
control type: ACTIVATION

Reference/BioCyc GLY
type: UnificationXref
id: GLY
db: BioCyc

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reaction78
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000148 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
right: L-Glutamic acid
right: Oxalacetic acid
spontaneous: false
left: L-Aspartic acid
left: Oxoglutaric acid
name: L-Aspartic acid + Oxoglutaric acid ↔ L-Glutamic acid + Oxalacetic acid
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 16977
type: UnificationXref
id: CHEBI:16977
db: ChEBI

Protein/278 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Aspartate aminotransferase, mitochondrial
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 16856
type: UnificationXref
id: CHEBI:16856
db: ChEBI

Reference/HMDB HMDB0000208
type: UnificationXref
id: HMDB0000208
db: HMDB

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/HMDB HMDB0000574
type: UnificationXref
id: HMDB0000574
db: HMDB

γ-Aminobutyric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000112
xref: Reference/ChemSpider 116
xref: Reference/PubChem-compound 119
xref: Reference/CAS 56-12-2
xref: Reference/BioCyc 4-AMINO-BUTYRATE
xref: Reference/ChEBI CHEBI 16865
xref: Reference/KEGG Compound C00334
chemical formula: C4H9NO2
molecular weight: 103.06333
structure: ChemicalStructure/PW C000071

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Phosphoribosyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00119
xref: Reference/ChemSpider 7062
xref: Reference/CAS 7540-64-9
xref: Reference/HMDB HMDB0000280
xref: Reference/PubChem-compound 7339
xref: Reference/BioCyc PRPP
xref: Reference/ChEBI CHEBI 17111
chemical formula: C5H13O14P3
molecular weight: 389.9518
structure: ChemicalStructure/PW C000190

Reference/HMDB HMDB0001301
type: UnificationXref
id: HMDB0001301
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/BioCyc GMP
type: UnificationXref
id: GMP
db: BioCyc

ChemicalStructure/PW C000134
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(=O)C(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/CAS 692-29-5
type: UnificationXref
id: 692-29-5
db: CAS

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 30915
type: UnificationXref
id: CHEBI:30915
db: ChEBI

Fructose 6-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 643-13-0
xref: Reference/HMDB HMDB0000124
xref: Reference/KEGG Compound C00085
xref: Reference/ChEBI CHEBI 15946
xref: Reference/BioCyc FRUCTOSE-6P
xref: Reference/PubChem-compound 69507
xref: Reference/ChemSpider 62713
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C000079

Reference/CAS 1398-61-4
type: UnificationXref
id: 1398-61-4
db: CAS

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Glutamine--tRNA ligase
type: Protein
entity reference: Glutamine--tRNA ligase

Reference/BioCyc l-delta(1)-pyrroline 5-carboxylate
type: UnificationXref
id: l-delta(1)-pyrroline_5-carboxylate
db: BioCyc

Glycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000123
xref: Reference/BioCyc GLY
xref: Reference/ChemSpider 730
xref: Reference/PubChem-compound 5257127
xref: Reference/CAS 56-40-6
xref: Reference/ChEBI CHEBI 15428
xref: Reference/KEGG Compound C00037
chemical formula: C2H5NO2
molecular weight: 75.03203
structure: ChemicalStructure/PW C000078

Reference/SMPDB SMP0000046
type: UnificationXref
id: SMP0000046
db: SMPDB

Reference/SMPDB SMP0000044
type: UnificationXref
id: SMP0000044
db: SMPDB

Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
type: Protein
cellular location: Cytoplasm
entity reference: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

Reference/ChEBI CHEBI 15652
type: UnificationXref
id: CHEBI:15652
db: ChEBI

Reference/ChEBI CHEBI 16865
type: UnificationXref
id: CHEBI:16865
db: ChEBI

CAD protein
type: ProteinReference
xref: Reference/UniProt P27708
organism: Homo sapiens

ReactionCatalysis2
type: Catalysis
controller: Alanine aminotransferase 1
controlled: 2.6.1.2
control type: ACTIVATION

Glutamate--cysteine ligase regulatory subunit
type: Protein
cellular location: Cytoplasm
entity reference: Glutamate--cysteine ligase regulatory subunit

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Compound/PW C001441 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/SMPDB SMP0000050
type: UnificationXref
id: SMP0000050
db: SMPDB

Reference/UniProt P48506
type: UnificationXref
id: P48506
db: UniProt

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Compound/PW C040034 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/UniProt P48507
type: UnificationXref
id: P48507
db: UniProt

Reference/HMDB HMDB0001554
type: UnificationXref
id: HMDB0001554
db: HMDB

Reference/HMDB HMDB0000223
type: UnificationXref
id: HMDB0000223
db: HMDB

Reference/PubChem-compound 5257127
type: UnificationXref
id: 5257127
db: PubChem-compound

Glutathione
type: SmallMoleculeReference
xref: Reference/CAS 70-18-8
xref: Reference/HMDB HMDB0000125
xref: Reference/BioCyc OXIDIZED-GLUTATHIONE
xref: Reference/KEGG Compound C00051
xref: Reference/ChEBI CHEBI 16856
xref: Reference/PubChem-compound 124886
xref: Reference/ChemSpider 111188
chemical formula: C10H17N3O6S
molecular weight: 307.0838
structure: ChemicalStructure/PW C000080

Compound/PW C000837 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-D-Glucosamine 6-Phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P47897
type: UnificationXref
id: P47897
db: UniProt

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Reference/SMPDB SMP0000059
type: UnificationXref
id: SMP0000059
db: SMPDB

γ-Glutamylcysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: γ-Glutamylcysteine

Coenzyme A
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Coenzyme A

Protein/242 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: 4-aminobutyrate aminotransferase, mitochondrial
stoichiometric coefficient: 2.0

Reference/PubChem-compound 69507
type: UnificationXref
id: 69507
db: PubChem-compound

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

Reference/PubChem-compound 1112
type: UnificationXref
id: 1112
db: PubChem-compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

ChemicalStructure/PW C000105
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](N)C(O)=O

Reference/PubChem-compound 5950
type: UnificationXref
id: 5950
db: PubChem-compound

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Protein/667 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glutamate decarboxylase 1
stoichiometric coefficient: 2.0

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Reference/HMDB HMDB0000112
type: UnificationXref
id: HMDB0000112
db: HMDB

Reference/ChemSpider 116
type: UnificationXref
id: 116
db: ChemSpider

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

L-Glutamyl-tRNA(Glu)
type: Rna
cellular location: Cytoplasm
entity reference: L-Glutamyl-tRNA(Glu)

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/PubChem-compound 6804
type: UnificationXref
id: 6804
db: PubChem-compound

Glutamine synthetase
type: Protein
cellular location: Cytoplasm
entity reference: Glutamine synthetase

Reference/KEGG Compound C03090
type: UnificationXref
id: C03090
db: KEGG Compound

Reference/CAS 463-79-6
type: UnificationXref
id: 463-79-6
db: CAS

2-Hydroxyglutric Aciduria (D and L Form)
type: Pathway
pathway order: PathwayEnzymeReaction/211531
pathway order: PathwayEnzymeReaction/39
pathway order: PathwayEnzymeReaction/3573
pathway order: PathwaySubPathway/858
pathway order: PathwayEnzymeReaction/3552
pathway order: PathwayEnzymeReaction/3574
pathway order: PathwayEnzymeReaction/3531
pathway order: PathwayEnzymeReaction/3575
pathway order: PathwaySubPathway/856
pathway order: PathwayEnzymeReaction/3576
pathway order: PathwaySubPathway/139
pathway order: PathwayEnzymeReaction/3570
pathway order: PathwaySubPathway/855
pathway order: PathwayEnzymeReaction/3571
pathway order: PathwaySubPathway/137
pathway order: PathwayEnzymeReaction/3572
pathway order: PathwaySubPathway/138
pathway order: PathwayEnzymeReaction/3527
pathway order: PathwayEnzymeReaction/3524
pathway order: PathwayEnzymeReaction/3569
pathway order: PathwayEnzymeReaction/46
pathway order: PathwaySubPathway/140
pathway order: PathwayEnzymeReaction/3543
pathway order: PathwayEnzymeReaction/3561
pathway order: PathwayEnzymeReaction/3577
pathway order: PathwayEnzymeReaction/3556
pathway order: PathwayEnzymeReaction/3578
pathway order: PathwayEnzymeReaction/7779
pathway order: PathwayEnzymeReaction/52
pathway component: 6.3.1.2
pathway component: ReactionCatalysis114
pathway component: ReactionCatalysis112
pathway component: Reaction78
pathway component: Reaction39
pathway component: 6.1.1.18
pathway component: 2.7.1.59
pathway component: 1.4.1.3
pathway component: 2.6.1.16
pathway component: ReactionCatalysis2211
pathway component: ReactionCatalysis2212
pathway component: ReactionCatalysis26
pathway component: 1.2.1.24
pathway component: 6.3.4.16
pathway component: ReactionCatalysis2
pathway component: 2.4.2.14
pathway component: 3.5.1.2
pathway component: 1.2.1.88
pathway component: ReactionCatalysis2225
pathway component: Histidine Metabolism
pathway component: ReactionCatalysis2222
pathway component: ReactionCatalysis2221
pathway component: ReactionCatalysis2224
pathway component: ReactionCatalysis2223
pathway component: Reaction1322
pathway component: Pyrimidine Metabolism
pathway component: ReactionCatalysis38
pathway component: ReactionCatalysis39
pathway component: ReactionCatalysis133
pathway component: ReactionCatalysis37
pathway component: ReactionCatalysis372
pathway component: Purine Metabolism
pathway component: Glutathione Metabolism
pathway component: Urea Cycle
pathway component: Reaction494
pathway component: 1.8.1.7
pathway component: 2.3.1.4
pathway component: ReactionCatalysis41
pathway component: ReactionCatalysis43
pathway component: ReactionCatalysis44
pathway component: 2.6.1.2
pathway component: Arginine and Proline Metabolism
pathway component: 6.3.2.3
pathway component: 4.1.1.15
pathway component: 6.1.1.17
pathway component: 6.3.2.2
pathway component: ReactionCatalysis2202
pathway component: 6.3.5.2
pathway component: ReactionCatalysis2201
xref: Reference/PathWhiz PW000212

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Glutathione Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway139
pathway component: SubPathwayInteraction139
xref: Reference/PathWhiz PW000004
xref: Reference/SMPDB SMP0000015
name: SubPathway

Reference/ChEBI CHEBI 16960
type: UnificationXref
id: CHEBI:16960
db: ChEBI

Reference/ChEBI CHEBI 15873
type: UnificationXref
id: CHEBI:15873
db: ChEBI

2.3.1.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000969 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000837 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cell Membrane/Stoichiometry/1.0
right: N-Acetyl-D-Glucosamine 6-Phosphate
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.4
left: Acetyl-CoA
left: Glucosamine 6-phosphate
name: Acetyl-CoA + Glucosamine 6-phosphate → Coenzyme A + N-Acetyl-D-Glucosamine 6-Phosphate
conversion direction: LEFT_TO_RIGHT

Protein/965 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: N-acetyl-D-glucosamine kinase
stoichiometric coefficient: 2.0

Reference/PubChem-compound 440996
type: UnificationXref
id: 440996
db: PubChem-compound

Xanthylic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Xanthylic acid

Reference/HMDB HMDB0000123
type: UnificationXref
id: HMDB0000123
db: HMDB

Compound/PW C001144 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000243
type: UnificationXref
id: HMDB0000243
db: HMDB

Reference/HMDB HMDB0000125
type: UnificationXref
id: HMDB0000125
db: HMDB

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/HMDB HMDB0000124
type: UnificationXref
id: HMDB0000124
db: HMDB

Arginine and Proline Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway137
pathway order: SubPathwayInteractionSteps/SubPathway858
pathway component: SubPathwayInteraction137
pathway component: SubPathwayInteraction858
xref: Reference/PathWhiz PW000010
xref: Reference/SMPDB SMP0000020
name: SubPathway

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

L-Glutaminyl-tRNA(Gln)
type: RnaReference

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Compound/PW C001034 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 2.0

tRNA(Gln)
type: RnaReference
xref: Reference/INSDC 945257

ChemicalStructure/PW C000123
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(O)=O)C(O)=O

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Succinic acid semialdehyde
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Succinic acid semialdehyde

Protein/658 Mitochondrion/Stoichiometry/6.0
type: Stoichiometry
physical entity: Glutamate dehydrogenase 1, mitochondrial
stoichiometric coefficient: 6.0

Reference/CAS 70-18-8
type: UnificationXref
id: 70-18-8
db: CAS

Protein/491 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate--cysteine ligase catalytic subunit
stoichiometric coefficient: 1.0

Reference/BioCyc SUCC-S-ALD
type: UnificationXref
id: SUCC-S-ALD
db: BioCyc

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Compound/PW C001847 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxidized glutathione
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000969
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Compound/PW C000826 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Glutamylcysteine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5255796
type: UnificationXref
id: 5255796
db: PubChem-compound

Compound/PW C000174 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000972
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC=O

Acetyl-CoA
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Acetyl-CoA

Alanine aminotransferase 1
type: Complex
component stoichiometry: Protein/795 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Alanine aminotransferase 1

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Guanosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 85-32-5
xref: Reference/ChEBI CHEBI 17345
xref: Reference/BioCyc GMP
xref: Reference/PubChem-compound 6804
xref: Reference/KEGG Compound C00144
xref: Reference/ChemSpider 6545
xref: Reference/HMDB HMDB0001397
chemical formula: C10H14N5O8P
molecular weight: 363.058
structure: ChemicalStructure/PW C001080

CAD protein
type: Protein
cellular location: Cytoplasm
entity reference: CAD protein

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc CARBAMOYL-P
type: UnificationXref
id: CARBAMOYL-P
db: BioCyc

Reference/UniProt P30038
type: UnificationXref
id: P30038
db: UniProt

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/PathWhiz PW000212
type: UnificationXref
id: PW000212
db: PathWhiz

Reference/ChEBI CHEBI 17515
type: UnificationXref
id: CHEBI:17515
db: ChEBI

Glutamate decarboxylase 1
type: Protein
cellular location: Cytoplasm
entity reference: Glutamate decarboxylase 1

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Compound/PW C000134 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxoglutaric acid
stoichiometric coefficient: 1.0

Carbon dioxide
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Carbon dioxide

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/UniProt P49915
type: UnificationXref
id: P49915
db: UniProt

Reference/ChEBI CHEBI 1372
type: UnificationXref
id: CHEBI:1372
db: ChEBI

ChemicalStructure/PW C000862
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)OP(O)(O)=O

Reference/ChemSpider 1080
type: UnificationXref
id: 1080
db: ChemSpider

Protein/325 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Amidophosphoribosyltransferase
stoichiometric coefficient: 4.0

Reference/PubChem-compound 22639876
type: UnificationXref
id: 22639876
db: PubChem-compound

Glucosamine 6-phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Glucosamine 6-phosphate

Reference/SMPDB SMP0000136
type: UnificationXref
id: SMP0000136
db: SMPDB

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/SMPDB SMP0000015
type: UnificationXref
id: SMP0000015
db: SMPDB

Reference/ChEBI CHEBI 15784
type: UnificationXref
id: CHEBI:15784
db: ChEBI

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

ChemicalStructure/PW C001916
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Reference/UniProt P80404
type: UnificationXref
id: P80404
db: UniProt

Reference/KEGG Compound C00857
type: UnificationXref
id: C00857
db: KEGG Compound

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Oxalacetic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxalacetic acid

Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

ChemicalStructure/PW C000826
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(=O)N[C@@H](CS)C(O)=O)C(O)=O

Reference/CAS 127-17-3
type: UnificationXref
id: 127-17-3
db: CAS

Reference/PubChem-compound 439217
type: UnificationXref
id: 439217
db: PubChem-compound

Reaction494
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001916 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000862 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/2.0
right: Carbamoyl phosphate
right: L-Glutamic acid
right: Adenosine diphosphate
right: Phosphoric acid
spontaneous: false
left: Water
left: Adenosine triphosphate
left: L-Glutamine
left: Carbonic acid
name: 2 Adenosine triphosphate + Carbonic acid + L-Glutamine + Water → 2 Adenosine diphosphate + Carbamoyl phosphate + L-Glutamic acid + Phosphoric acid
conversion direction: LEFT_TO_RIGHT

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Compound/PW C001003 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-Pyrroline-5-carboxylic acid
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000020
type: UnificationXref
id: SMP0000020
db: SMPDB

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Compound/PW C000190 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl pyrophosphate
stoichiometric coefficient: 1.0

Glucosamine 6-phosphate N-acetyltransferase
type: Protein
cellular location: Cell Membrane
entity reference: Glucosamine 6-phosphate N-acetyltransferase

Reference/ChEBI CHEBI 17858
type: UnificationXref
id: CHEBI:17858
db: ChEBI

Glucosamine 6-phosphate N-acetyltransferase
type: ProteinReference
xref: Reference/UniProt Q96EK6
organism: Homo sapiens

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

N-acetyl-D-glucosamine kinase
type: Protein
cellular location: Cytoplasm
entity reference: N-acetyl-D-glucosamine kinase

Reference/ChemSpider 6545
type: UnificationXref
id: 6545
db: ChemSpider

Glutathione
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Glutathione

ChemicalStructure/PW C000837
type: ChemicalStructure
structure format: SMILES

Phosphoric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphoric acid

Glutamate--cysteine ligase
type: Complex
component stoichiometry: Protein/491 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/492 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Glutamate--cysteine ligase regulatory subunit
component: Glutamate--cysteine ligase catalytic subunit

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Oxidized glutathione
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxidized glutathione

Xanthylic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15652
xref: Reference/PubChem-compound 73323
xref: Reference/HMDB HMDB0001554
xref: Reference/KEGG Compound C00655
xref: Reference/ChemSpider 66054
xref: Reference/CAS 523-98-8
xref: Reference/BioCyc XANTHOSINE-5-PHOSPHATE
chemical formula: C10H13N4O9P
molecular weight: 364.04202
structure: ChemicalStructure/PW C001196

Reference/ChEBI CHEBI 28976
type: UnificationXref
id: CHEBI:28976
db: ChEBI

Protein/736 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glutathione synthetase
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

Compound/PW C001858 Cytoplasm/Stoichiometry/3.0
type: Stoichiometry
physical entity: Chitin
stoichiometric coefficient: 3.0

Compound/PW C000071 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Aminobutyric acid
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Mitochondrion
entity reference: NADH

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

ReactionCatalysis114
type: Catalysis
controller: Glutamine--fructose-6-phosphate aminotransferase
controlled: 2.6.1.16
control type: ACTIVATION

ReactionCatalysis112
type: Catalysis
controller: Glucosamine 6-phosphate N-acetyltransferase
controlled: 2.3.1.4
control type: ACTIVATION

Reference/BioCyc 2-KETOGLUTARATE
type: UnificationXref
id: 2-KETOGLUTARATE
db: BioCyc

6.1.1.18
type: BiochemicalReaction
participant stoichiometry: RNA/41/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: RNA/42/Stoichiometry/1.0
right: L-Glutaminyl-tRNA(Gln)
right: Adenosine monophosphate
right: Pyrophosphate
spontaneous: false
EC number: 6.1.1.18
left: tRNA(Gln)
left: L-Glutamine
left: Adenosine triphosphate
name: Adenosine triphosphate + L-Glutamine + tRNA(Gln) → Adenosine monophosphate + L-Glutaminyl-tRNA(Gln) + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

2.7.1.59
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000837 Cytoplasm/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000914 Cytoplasm/Stoichiometry/3.0
participant stoichiometry: Compound/PW C001858 Cytoplasm/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/3.0
right: Adenosine triphosphate
right: Chitin
spontaneous: false
EC number: 2.7.1.59
left: N-Acetyl-D-Glucosamine 6-Phosphate
left: Adenosine diphosphate ribose
name: 3 Adenosine diphosphate ribose + 3 N-Acetyl-D-Glucosamine 6-Phosphate → 3 Adenosine triphosphate + 3 Chitin
conversion direction: LEFT_TO_RIGHT

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001858
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/UniProt Q96EK6
type: UnificationXref
id: Q96EK6
db: UniProt

Aspartate aminotransferase, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Aspartate aminotransferase, mitochondrial

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

N-acetyl-D-glucosamine kinase
type: Complex
component stoichiometry: Protein/965 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: N-acetyl-D-glucosamine kinase

Phosphoric acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Phosphoric acid

Amidophosphoribosyltransferase
type: Complex
component stoichiometry: Protein/325 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Amidophosphoribosyltransferase

L-Alanine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Alanine

Oxoglutaric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxoglutaric acid

ReactionCatalysis2211
type: Catalysis
controller: CAD protein
controlled: Reaction494
control type: ACTIVATION

Reference/ChEBI CHEBI 32816
type: UnificationXref
id: CHEBI:32816
db: ChEBI

Compound/PW C000146 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

ReactionCatalysis2212
type: Catalysis
controller: GMP synthase [glutamine-hydrolyzing]
controlled: 6.3.5.2
control type: ACTIVATION

Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Compound/PW C001099 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Compound/PW C000972 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid semialdehyde
stoichiometric coefficient: 1.0

Reference/PubChem-compound 278
type: UnificationXref
id: 278
db: PubChem-compound

Aspartate aminotransferase, mitochondrial
type: Complex
component stoichiometry: Protein/278 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Aspartate aminotransferase, mitochondrial

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/PathWhiz PW000010
type: UnificationXref
id: PW000010
db: PathWhiz

6.3.4.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001034 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001316 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrion/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001441 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000862 Mitochondrion/Stoichiometry/1.0
right: Carbamoyl phosphate
right: Phosphoric acid
right: Adenosine diphosphate
spontaneous: false
EC number: 6.3.4.16
left: Carbon dioxide
left: Adenosine triphosphate
left: Ammonia
left: Water
name: 2 Adenosine triphosphate + Ammonia + Carbon dioxide + Water → 2 Adenosine diphosphate + Carbamoyl phosphate + Phosphoric acid
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/UniProt P31327
type: UnificationXref
id: P31327
db: UniProt

Compound/PW C000078 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Nicotinic acid adenine dinucleotide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001179
xref: Reference/ChEBI CHEBI 18304
xref: Reference/CAS 6450-77-7
xref: Reference/ChemSpider 145043
xref: Reference/BioCyc DEAMIDO-NAD
xref: Reference/KEGG Compound C00857
xref: Reference/PubChem-compound 165491
chemical formula: C21H27N6O15P2
molecular weight: 665.10095
structure: ChemicalStructure/PW C000915

Adenosine diphosphate ribose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001178
xref: Reference/ChEBI CHEBI 16960
xref: Reference/BioCyc ADENOSINE DIPHOSPHATE RIBOSE
xref: Reference/PubChem-compound 192
xref: Reference/ChemSpider 187
xref: Reference/CAS 20762-30-5
xref: Reference/KEGG Compound C00301
chemical formula: C15H23N5O14P2
molecular weight: 559.07166
structure: ChemicalStructure/PW C000914

Reference/ChEBI CHEBI 17672
type: UnificationXref
id: CHEBI:17672
db: ChEBI

ReactionCatalysis2225
type: Catalysis
controller: Succinate-semialdehyde dehydrogenase, mitochondrial
controlled: 1.2.1.24
control type: ACTIVATION

RNA/7 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamyl-tRNA(Glu)
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChEBI CHEBI 30744
type: UnificationXref
id: CHEBI:30744
db: ChEBI

Glutathione reductase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P00390
organism: Homo sapiens

ReactionCatalysis2222
type: Catalysis
controller: Glutamate--cysteine ligase
controlled: 6.3.2.2
control type: ACTIVATION

Reference/ChemSpider 111188
type: UnificationXref
id: 111188
db: ChemSpider

ReactionCatalysis2221
type: Catalysis
controller: Probable glutamate--tRNA ligase, mitochondrial
controlled: 6.1.1.17
control type: ACTIVATION

Compound/PW C000414 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 2.0

ReactionCatalysis2224
type: Catalysis
controller: Glutamate decarboxylase 1
controlled: 4.1.1.15
control type: ACTIVATION

ReactionCatalysis2223
type: Catalysis
controller: Glutathione synthetase
controlled: 6.3.2.3
control type: ACTIVATION

Reaction1322
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000915 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: L-Glutamic acid
right: NAD
right: Pyrophosphate
spontaneous: false
left: Water
left: Nicotinic acid adenine dinucleotide
left: Adenosine triphosphate
left: L-Glutamine
name: Adenosine triphosphate + L-Glutamine + Nicotinic acid adenine dinucleotide + Water → Adenosine monophosphate + L-Glutamic acid + NAD + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Glutathione synthetase
type: Complex
component stoichiometry: Protein/736 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Glutathione synthetase

ReactionCatalysis133
type: Catalysis
controller: Carbamoyl-phosphate synthase [ammonia], mitochondrial
controlled: 6.3.4.16
control type: ACTIVATION

Reference/KEGG Compound C00655
type: UnificationXref
id: C00655
db: KEGG Compound

Reference/CAS 56-12-2
type: UnificationXref
id: 56-12-2
db: CAS

Reference/CAS 27025-41-8
type: UnificationXref
id: 27025-41-8
db: CAS

Reference/PathWhiz PW000004
type: UnificationXref
id: PW000004
db: PathWhiz

ReactionCatalysis372
type: Catalysis
controller: Aspartate aminotransferase, mitochondrial
controlled: Reaction78
control type: ACTIVATION

Reference/UniProt Q9UJ70
type: UnificationXref
id: Q9UJ70
db: UniProt

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Compound/PW C000969 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosamine 6-phosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1196
type: UnificationXref
id: 1196
db: PubChem-compound

γ-Aminobutyric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: γ-Aminobutyric acid
name: SubPathwayInput

Reference/BioCyc PRPP
type: UnificationXref
id: PRPP
db: BioCyc

Compound/PW C000940 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Glucosamine 6-phosphate N-acetyltransferase
type: Complex
component stoichiometry: Protein/50 Cell Membrane/Stoichiometry/2.0
cellular location: Cell Membrane
component: Glucosamine 6-phosphate N-acetyltransferase

Protein/151 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

Succinate-semialdehyde dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Succinate-semialdehyde dehydrogenase, mitochondrial

Reference/PubChem-compound 192
type: UnificationXref
id: 192
db: PubChem-compound

tRNA(Glu)
type: RnaReference
xref: Reference/ChEBI CHEBI 29175
organism: Homo sapiens

L-Glutamyl-tRNA(Glu)
type: RnaReference
xref: Reference/ChEBI CHEBI 29157
organism: Homo sapiens

Reference/PubChem-compound 1060
type: UnificationXref
id: 1060
db: PubChem-compound

Reference/KEGG Compound C00669
type: UnificationXref
id: C00669
db: KEGG Compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Glutaminase liver isoform, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Glutaminase liver isoform, mitochondrial

Reference/CAS 523-98-8
type: UnificationXref
id: 523-98-8
db: CAS

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

1-Pyrroline-5-carboxylic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 1-Pyrroline-5-carboxylic acid
name: SubPathwayOutput

Reference/KEGG Compound C00301
type: UnificationXref
id: C00301
db: KEGG Compound

ChemicalStructure/PW C001847
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P00505
type: UnificationXref
id: P00505
db: UniProt

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Reference/BioCyc DEAMIDO-NAD
type: UnificationXref
id: DEAMIDO-NAD
db: BioCyc

ChemicalStructure/PW C000882
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 187
type: UnificationXref
id: 187
db: ChemSpider

Reference/CAS 2906-39-0
type: UnificationXref
id: 2906-39-0
db: CAS

Compound/PW C000448 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Reference/CAS 20762-30-5
type: UnificationXref
id: 20762-30-5
db: CAS

6.3.2.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000826 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Glutathione
right: Adenosine diphosphate
right: Phosphate
spontaneous: false
EC number: 6.3.2.3
left: Glycine
left: Adenosine triphosphate
left: γ-Glutamylcysteine
name: Adenosine triphosphate + Glycine + γ-Glutamylcysteine → Adenosine diphosphate + Glutathione + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Compound/PW C000721 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

4.1.1.15
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000071 Cytoplasm/Stoichiometry/1.0
right: Carbon dioxide
right: γ-Aminobutyric acid
spontaneous: false
EC number: 4.1.1.15
left: L-Glutamic acid
name: L-Glutamic acid → Carbon dioxide + γ-Aminobutyric acid
conversion direction: LEFT_TO_RIGHT

6.1.1.17
type: BiochemicalReaction
participant stoichiometry: RNA/8 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: RNA/7 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000134 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: L-Glutamyl-tRNA(Glu)
right: Pyrophosphate
spontaneous: false
EC number: 6.1.1.17
left: Oxoglutaric acid
left: Adenosine triphosphate
left: tRNA(Glu)
name: Adenosine triphosphate + Oxoglutaric acid + tRNA(Glu) → Adenosine monophosphate + L-Glutamyl-tRNA(Glu) + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

6.3.2.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000826 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000914 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Adenosine diphosphate ribose
right: γ-Glutamylcysteine
right: Phosphate
spontaneous: false
EC number: 6.3.2.2
left: L-Cysteine
left: Adenosine triphosphate
left: L-Glutamic acid
name: Adenosine triphosphate + L-Cysteine + L-Glutamic acid → Adenosine diphosphate ribose + Phosphate + γ-Glutamylcysteine
conversion direction: LEFT_TO_RIGHT

6.3.5.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001080 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001196 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: Guanosine monophosphate
right: L-Glutamic acid
right: Pyrophosphate
spontaneous: false
EC number: 6.3.5.2
left: Water
left: Adenosine triphosphate
left: L-Glutamine
left: Xanthylic acid
name: Adenosine triphosphate + L-Glutamine + Water + Xanthylic acid → Adenosine monophosphate + Guanosine monophosphate + L-Glutamic acid + Pyrophosphate
conversion direction: LEFT_TO_RIGHT