Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Compound/PW C001191 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Ribose 5-phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17345
type: UnificationXref
id: CHEBI:17345
db: ChEBI

2'-Deoxyguanosine 5'-monophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 65059
xref: Reference/ChEBI CHEBI 16192
xref: Reference/BioCyc DGMP
xref: Reference/CAS 902-04-5
xref: Reference/KEGG Compound C00362
xref: Reference/ChemSpider 58570
xref: Reference/HMDB HMDB0001044
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000822

Reference/BioCyc IDP
type: UnificationXref
id: IDP
db: BioCyc

Compound/PW C000882 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Phosphoribosylamine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00672
type: UnificationXref
id: C00672
db: KEGG Compound

Reference/UniProt Q5MY95
type: UnificationXref
id: Q5MY95
db: UniProt

Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16497
type: UnificationXref
id: CHEBI:16497
db: ChEBI

Phosphoribosylformylglycineamidine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphoribosylformylglycineamidine

Reference/KEGG Compound C01762
type: UnificationXref
id: C01762
db: KEGG Compound

Compound/PW C000774 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 10-Formyltetrahydrofolate
stoichiometric coefficient: 1.0

Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/PubChem-compound 165388
type: UnificationXref
id: 165388
db: PubChem-compound

Inosine triphosphate pyrophosphatase
type: Complex
component stoichiometry: Protein/422 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Inosine triphosphate pyrophosphatase

Deoxyadenosine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Deoxyadenosine

Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

5'-Phosphoribosyl-N-formylglycinamide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5'-Phosphoribosyl-N-formylglycinamide

Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Tetrahydrofolic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Tetrahydrofolic acid

Compound/PW C001196 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Xanthylic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00206
type: UnificationXref
id: C00206
db: KEGG Compound

Reference/ChEBI CHEBI 20506
type: UnificationXref
id: CHEBI:20506
db: ChEBI

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Uric acid
type: SmallMolecule
cellular location: Peroxisome
entity reference: Uric acid

D-Ribose 5-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: D-Ribose 5-phosphate

Reference/ChEBI CHEBI 17596
type: UnificationXref
id: CHEBI:17596
db: ChEBI

Protein/560 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: GMP synthase [glutamine-hydrolyzing]
stoichiometric coefficient: 2.0

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17111
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Reference/BioCyc 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
type: UnificationXref
id: 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
db: BioCyc

Reference/UniProt Q8NBU5
type: UnificationXref
id: Q8NBU5
db: UniProt

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

NAD
type: SmallMolecule
cellular location: Peroxisome
entity reference: NAD

Reference/ChEBI CHEBI 16235
type: UnificationXref
id: CHEBI:16235
db: ChEBI

Compound/PW C000195 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uric acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 9679
type: UnificationXref
id: 9679
db: PubChem-compound

Reference/ChEBI CHEBI 18413
type: UnificationXref
id: CHEBI:18413
db: ChEBI

Reference/PubChem-compound 8583
type: UnificationXref
id: 8583
db: PubChem-compound

Reference/PubChem-compound 8582
type: UnificationXref
id: 8582
db: PubChem-compound

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5745
type: UnificationXref
id: 5745
db: ChemSpider

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 15993
type: UnificationXref
id: 15993
db: PubChem-compound

Reference/BioCyc L-ASPARTATE
type: UnificationXref
id: L-ASPARTATE
db: BioCyc

Compound/PW C001034 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 2.0

Reference/ChemSpider 1142
type: UnificationXref
id: 1142
db: ChemSpider

Reference/KEGG Compound C00212
type: UnificationXref
id: C00212
db: KEGG Compound

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/UniProt P00813
type: UnificationXref
id: P00813
db: UniProt

Reference/CAS 7540-64-9
type: UnificationXref
id: 7540-64-9
db: CAS

Carbon dioxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Carbon dioxide

ChemicalStructure/PW C001080
type: ChemicalStructure
structure format: SMILES

Guanosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine triphosphate

Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
type: Protein
cellular location: Cytoplasm
entity reference: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Reference/BioCyc CPD-3762
type: UnificationXref
id: CPD-3762
db: BioCyc

Deoxyadenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Deoxyadenosine triphosphate

Reference/CAS 958-09-8
type: UnificationXref
id: 958-09-8
db: CAS

Reference/KEGG Compound C04823
type: UnificationXref
id: C04823
db: KEGG Compound

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/UniProt P23921
type: UnificationXref
id: P23921
db: UniProt

ATPase family AAA domain-containing protein 1
type: ProteinReference
xref: Reference/UniProt Q8NBU5
organism: Homo sapiens

Guanosine 2',3'-cyclic phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0011629
xref: Reference/KEGG Compound C06194
xref: Reference/ChEBI CHEBI 28181
xref: Reference/ChemSpider 83792
xref: Reference/CAS 634-02-6
xref: Reference/BioCyc CPD-3709
xref: Reference/PubChem-compound 92823
chemical formula: C10H12N5O7P
molecular weight: 345.04742
structure: ChemicalStructure/PW C007218

Reference/PubChem-compound 439167
type: UnificationXref
id: 439167
db: PubChem-compound

Xanthine dehydrogenase/oxidase
type: ProteinReference
xref: Reference/UniProt P47989
organism: Homo sapiens

Reference/ChemSpider 83792
type: UnificationXref
id: 83792
db: ChemSpider

Reference/PubChem-compound 64959
type: UnificationXref
id: 64959
db: PubChem-compound

Guanine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanine

Compound/PW C000088 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Ribonucleoside-diphosphate reductase subunit M2
type: Protein
cellular location: Cytosol
entity reference: Ribonucleoside-diphosphate reductase subunit M2

L-Glutamic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamic acid

Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
type: ProteinReference
xref: Reference/UniProt P50583
organism: Homo sapiens

Ribonucleoside-diphosphate reductase large subunit
type: ProteinReference
xref: Reference/UniProt P23921
organism: Homo sapiens

Reference/KEGG Compound C00234
type: UnificationXref
id: C00234
db: KEGG Compound

Ribonucleoside-diphosphate reductase subunit M2
type: ProteinReference
xref: Reference/UniProt P31350
organism: Homo sapiens

Glycineamideribotide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glycineamideribotide

Xanthine dehydrogenase/oxidase
type: Protein
cellular location: Peroxisome
entity reference: Xanthine dehydrogenase/oxidase

Reference/PubChem-compound 165186
type: UnificationXref
id: 165186
db: PubChem-compound

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

Compound/PW C000936 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Compound/PW C000203 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Xanthosine
stoichiometric coefficient: 1.0

Adenosine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

SAICAR
type: SmallMoleculeReference
xref: Reference/CAS 3031-95-6
xref: Reference/BioCyc P-RIBOSYL-4-SUCCCARB-AMINOIMIDAZOLE
xref: Reference/ChEBI CHEBI 18319
xref: Reference/HMDB HMDB0000797
xref: Reference/KEGG Compound C04823
xref: Reference/PubChem-compound 160666
xref: Reference/ChemSpider 141175
chemical formula: C13H19N4O12P
molecular weight: 454.0737
structure: ChemicalStructure/PW C000637

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/ChemSpider 1151
type: UnificationXref
id: 1151
db: ChemSpider

Reference/KEGG Compound C00242
type: UnificationXref
id: C00242
db: KEGG Compound

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Compound/PW C001441 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Reference/CAS 135-16-0
type: UnificationXref
id: 135-16-0
db: CAS

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

NADP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADP

3.6.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001080 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001033 Cytoplasm/Stoichiometry/1.0
right: Guanosine monophosphate
right: Guanosine triphosphate
spontaneous: false
EC number: 3.6.1.17
left: Water
left: Diguanosine tetraphosphate
name: Diguanosine tetraphosphate + Water → Guanosine monophosphate + Guanosine triphosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C007218
type: ChemicalStructure
structure format: SMILES

Nucleoside diphosphate kinase 6
type: ProteinReference
xref: Reference/UniProt O75414
organism: Homo sapiens

ADP-sugar pyrophosphatase
type: ProteinReference
xref: Reference/UniProt Q9UKK9
organism: Homo sapiens

ReactionCatalysis617
type: Catalysis
controller: Nucleoside diphosphate kinase 6
controlled: 2.7.4.6
control type: ACTIVATION

5-Phosphoribosylamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001128
xref: Reference/ChEBI CHEBI 37737
xref: Reference/BioCyc 5-P-BETA-D-RIBOSYL-AMINE
xref: Reference/ChemSpider 388939
xref: Reference/KEGG Compound C03090
xref: Reference/PubChem-compound 439905
chemical formula: C5H12NO7P
molecular weight: 229.03514
structure: ChemicalStructure/PW C000882

Adenylosuccinate lyase
type: Protein
cellular location: Cytoplasm
entity reference: Adenylosuccinate lyase

Reference/UniProt P20839
type: UnificationXref
id: P20839
db: UniProt

Reference/BioCyc CPD-3709
type: UnificationXref
id: CPD-3709
db: BioCyc

3.6.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Peroxisome/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphoric acid
spontaneous: false
EC number: 3.6.1.3
left: Adenosine triphosphate
left: Water
name: Adenosine triphosphate + Water → Adenosine diphosphate + Phosphoric acid
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 58569
type: UnificationXref
id: 58569
db: ChemSpider

AMP deaminase 1
type: Protein
cellular location: Cytoplasm
entity reference: AMP deaminase 1

ReactionCatalysis653
type: Catalysis
controller: Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
controlled: 3.6.1.17
control type: ACTIVATION

Reference/ChEBI CHEBI 16039
type: UnificationXref
id: CHEBI:16039
db: ChEBI

Reference/ChEBI CHEBI 17368
type: UnificationXref
id: CHEBI:17368
db: ChEBI

Adenylosuccinate synthetase isozyme 2
type: Protein
cellular location: Cytoplasm
entity reference: Adenylosuccinate synthetase isozyme 2

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Ribonucleoside-diphosphate reductase large subunit
type: Protein
cellular location: Cytosol
entity reference: Ribonucleoside-diphosphate reductase large subunit

ReactionCatalysis2191
type: Catalysis
controller: Ectonucleoside triphosphate diphosphohydrolase 5
controlled: Reaction2295
control type: ACTIVATION

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

GMP reductase 1
type: Protein
cellular location: Cytoplasm
entity reference: GMP reductase 1

Compound/PW C007218 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine 2',3'-cyclic phosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Hypoxanthine
type: SmallMolecule
cellular location: Peroxisome
entity reference: Hypoxanthine

IDP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: IDP

AICAR
type: SmallMolecule
cellular location: Cytoplasm
entity reference: AICAR

Compound/PW C001161 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dADP
stoichiometric coefficient: 1.0

Deoxyguanosine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Deoxyguanosine

Guanylate cyclase
type: Complex
component stoichiometry: Protein/1001 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/1007 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Guanylate cyclase soluble subunit beta-1
component: Guanylate cyclase soluble subunit alpha-2

Compound/PW C001846 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: IDP
stoichiometric coefficient: 1.0

Reference/PubChem-compound 644173
type: UnificationXref
id: 644173
db: PubChem-compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/ChemSpider 58570
type: UnificationXref
id: 58570
db: ChemSpider

Reference/ChEBI CHEBI 16284
type: UnificationXref
id: CHEBI:16284
db: ChEBI

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00262
type: UnificationXref
id: C00262
db: KEGG Compound

Protein/823 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenylosuccinate synthetase isozyme 2
stoichiometric coefficient: 2.0

Reference/ChemSpider 388420
type: UnificationXref
id: 388420
db: ChemSpider

Compound/PW C001111 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl formamidocarboxamide
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

5-Phosphoribosylamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5-Phosphoribosylamine

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Reaction186
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001104 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001080 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Phosphate
right: Guanosine monophosphate
spontaneous: false
left: Water
left: Guanosine diphosphate
name: Guanosine diphosphate + Water → Guanosine monophosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 764
type: UnificationXref
id: 764
db: PubChem-compound

Reference/UniProt P31939
type: UnificationXref
id: P31939
db: UniProt

Reference/KEGG Compound C00037
type: UnificationXref
id: C00037
db: KEGG Compound

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

Reference/HMDB HMDB0000133
type: UnificationXref
id: HMDB0000133
db: HMDB

Reference/CAS 1927-31-7
type: UnificationXref
id: 1927-31-7
db: CAS

Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/CAS 69-93-2
type: UnificationXref
id: 69-93-2
db: CAS

Compound/PW C000198 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Xanthine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0000132
type: UnificationXref
id: HMDB0000132
db: HMDB

Reference/UniProt Q9Y233
type: UnificationXref
id: Q9Y233
db: UniProt

dGDP
type: SmallMolecule
cellular location: Cytosol
entity reference: dGDP

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/KEGG Compound C00286
type: UnificationXref
id: C00286
db: KEGG Compound

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

L-Glutamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamine

2.4.2.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000190 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000882 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
right: Water
right: Phosphoribosyl pyrophosphate
right: L-Glutamine
spontaneous: false
EC number: 2.4.2.14
left: 5-Phosphoribosylamine
left: L-Glutamic acid
left: Pyrophosphate
name: 5-Phosphoribosylamine + L-Glutamic acid + Pyrophosphate ↔ L-Glutamine + Phosphoribosyl pyrophosphate + Water
conversion direction: REVERSIBLE

Phosphoribosylformylglycinamidine synthase
type: ProteinReference
xref: Reference/UniProt O15067
organism: Homo sapiens

Reference/KEGG Compound C00049
type: UnificationXref
id: C00049
db: KEGG Compound

Reference/KEGG Compound C04640
type: UnificationXref
id: C04640
db: KEGG Compound

Reference/KEGG Compound C03794
type: UnificationXref
id: C03794
db: KEGG Compound

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001033
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 7062
type: UnificationXref
id: 7062
db: ChemSpider

Adenylosuccinate lyase
type: ProteinReference
xref: Reference/UniProt P30566
organism: Homo sapiens

Reference/HMDB HMDB0001235
type: UnificationXref
id: HMDB0001235
db: HMDB

Reference/KEGG Compound C00294
type: UnificationXref
id: C00294
db: KEGG Compound

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Reaction2295
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001177 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001161 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
right: Deoxyadenosine triphosphate
right: Water
spontaneous: false
left: dADP
left: Phosphate
name: Phosphate + dADP → Deoxyadenosine triphosphate + Water
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 13730
type: UnificationXref
id: 13730
db: PubChem-compound

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

6.3.4.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000114 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000413 Cytoplasm/Stoichiometry/1.0
right: Adenylsuccinic acid
right: Phosphate
right: Guanosine diphosphate
spontaneous: false
EC number: 6.3.4.4
left: L-Aspartic acid
left: Inosinic acid
left: Guanosine triphosphate
name: Guanosine triphosphate + Inosinic acid + L-Aspartic acid ↔ Adenylsuccinic acid + Guanosine diphosphate + Phosphate
conversion direction: REVERSIBLE

dADP
type: SmallMolecule
cellular location: Cytosol
entity reference: dADP

4.3.2.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000088 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000413 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Fumaric acid
right: Adenosine monophosphate
spontaneous: false
EC number: 4.3.2.2
left: Adenylsuccinic acid
name: Adenylsuccinic acid ↔ Adenosine monophosphate + Fumaric acid
conversion direction: REVERSIBLE

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

dADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: dADP

Amidophosphoribosyltransferase
type: ProteinReference
xref: Reference/UniProt Q06203
organism: Homo sapiens

Trifunctional purine biosynthetic protein adenosine-3
type: ProteinReference
xref: Reference/UniProt P22102
organism: Homo sapiens

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/HMDB HMDB0001489
type: UnificationXref
id: HMDB0001489
db: HMDB

Xanthine
type: SmallMolecule
cellular location: Peroxisome
entity reference: Xanthine

Reference/HMDB HMDB0000157
type: UnificationXref
id: HMDB0000157
db: HMDB

Reference/PubChem-compound 187790
type: UnificationXref
id: 187790
db: PubChem-compound

Phosphoric acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Phosphoric acid

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: Reference/UniProt P49915
organism: Homo sapiens

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

Compound/PW C000102 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hypoxanthine
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Trifunctional purine biosynthetic protein adenosine-3
type: Protein
cellular location: Cytoplasm
entity reference: Trifunctional purine biosynthetic protein adenosine-3

Adenylsuccinic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440122
xref: Reference/HMDB HMDB0000536
xref: Reference/CAS 19046-78-7
xref: Reference/KEGG Compound C03794
xref: Reference/ChEBI CHEBI 15919
xref: Reference/ChemSpider 389122
chemical formula: C14H18N5O11P
molecular weight: 463.07404
structure: ChemicalStructure/PW C000413

Reference/ChEBI CHEBI 17172
type: UnificationXref
id: CHEBI:17172
db: ChEBI

ChemicalStructure/PW C001007
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc XANTHOSINE-5-PHOSPHATE
type: UnificationXref
id: XANTHOSINE-5-PHOSPHATE
db: BioCyc

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Reference/BioCyc 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE
type: UnificationXref
id: 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE
db: BioCyc

Reference/CAS 58-61-7
type: UnificationXref
id: 58-61-7
db: CAS

Reference/UniProt O75356
type: UnificationXref
id: O75356
db: UniProt

Reference/KEGG Compound C05512
type: UnificationXref
id: C05512
db: KEGG Compound

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Ectonucleoside triphosphate diphosphohydrolase 5
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Ectonucleoside triphosphate diphosphohydrolase 5

Reference/ChemSpider 144813
type: UnificationXref
id: 144813
db: ChemSpider

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
type: ProteinReference
xref: Reference/UniProt Q9Y233
organism: Homo sapiens

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Deoxyadenosine triphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Deoxyadenosine triphosphate

Reference/CAS 2564-35-4
type: UnificationXref
id: 2564-35-4
db: CAS

Compound/PW C001080 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine monophosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C04677
type: UnificationXref
id: C04677
db: KEGG Compound

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/KEGG Compound C00081
type: UnificationXref
id: C00081
db: KEGG Compound

Reference/ChemSpider 9298
type: UnificationXref
id: 9298
db: ChemSpider

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/BioCyc DEOXYGUANOSINE
type: UnificationXref
id: DEOXYGUANOSINE
db: BioCyc

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0000175
type: UnificationXref
id: HMDB0000175
db: HMDB

5-Aminoimidazole ribonucleotide
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Aminoimidazole ribonucleotide

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Protein/554 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Adenylosuccinate lyase
stoichiometric coefficient: 4.0

Reference/PubChem-compound 92823
type: UnificationXref
id: 92823
db: PubChem-compound

Reference/HMDB HMDB0000189
type: UnificationXref
id: HMDB0000189
db: HMDB

Compound/PW C001104 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Compound/PW C000767 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: dGDP
stoichiometric coefficient: 1.0

Compound/PW C001355 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycineamideribotide
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

10-Formyltetrahydrofolate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 10-Formyltetrahydrofolate

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

5-Aminoimidazole ribonucleotide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5-Aminoimidazole ribonucleotide

Reference/PubChem-compound 160913
type: UnificationXref
id: 160913
db: PubChem-compound

Xanthosine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000299
xref: Reference/CAS 146-80-5
xref: Reference/ChEBI CHEBI 18107
xref: Reference/ChemSpider 58484
xref: Reference/PubChem-compound 64959
xref: Reference/KEGG Compound C01762
chemical formula: C10H12N4O6
molecular weight: 284.07568
structure: ChemicalStructure/PW C000203

Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

dGTP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: dGTP

Xanthosine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Xanthosine

Protein/1007 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanylate cyclase soluble subunit alpha-2
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000198
type: ChemicalStructure
structure format: SMILES
structure data: O=C1NC2=C(NC=N2)C(=O)N1

Reference/CAS 58-63-9
type: UnificationXref
id: 58-63-9
db: CAS

Reference/KEGG Compound C03373
type: UnificationXref
id: C03373
db: KEGG Compound

Compound/PW C001420 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Ectonucleoside triphosphate diphosphohydrolase 5
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Ectonucleoside triphosphate diphosphohydrolase 5

ChemicalStructure/PW C001042
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1OC(C[C@@H]1O)OP(O)(O)=O

ChemicalStructure/PW C000195
type: ChemicalStructure
structure format: SMILES
structure data: O=C1NC2=C(N1)C(=O)NC(=O)N2

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Reference/CAS 890-38-0
type: UnificationXref
id: 890-38-0
db: CAS

ChemicalStructure/PW C000190
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000191
type: UnificationXref
id: HMDB0000191
db: HMDB

Compound/PW C000936 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Compound/PW C001034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000195
type: UnificationXref
id: HMDB0000195
db: HMDB

Reference/HMDB HMDB0001044
type: UnificationXref
id: HMDB0001044
db: HMDB

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Compound/PW C000198 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Xanthine
stoichiometric coefficient: 1.0

Reference/CAS 25635-88-5
type: UnificationXref
id: 25635-88-5
db: CAS

Adenylosuccinate lyase
type: Complex
component stoichiometry: Protein/554 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Adenylosuccinate lyase

Ribose-phosphate pyrophosphokinase 3
type: ProteinReference
xref: Reference/UniProt P21108
organism: Homo sapiens

Compound/PW C000127 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inosine
stoichiometric coefficient: 1.0

Adenylate kinase isoenzyme 1
type: ProteinReference
xref: Reference/UniProt P00568
organism: Homo sapiens

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
type: Protein
cellular location: Cytoplasm
entity reference: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Reference/UniProt Q9UKK9
type: UnificationXref
id: Q9UKK9
db: UniProt

Reference/BioCyc 5-P-BETA-D-RIBOSYL-AMINE
type: UnificationXref
id: 5-P-BETA-D-RIBOSYL-AMINE
db: BioCyc

NAD
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NAD

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB

Compound/PW C001033 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Diguanosine tetraphosphate
stoichiometric coefficient: 1.0

Compound/PW C000413 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenylsuccinic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 141370
type: UnificationXref
id: 141370
db: ChemSpider

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Compound/PW C000050 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyinosine
stoichiometric coefficient: 1.0

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Protein/107 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribonucleoside-diphosphate reductase subunit M2
stoichiometric coefficient: 1.0

Adenylosuccinate synthetase isozyme 2
type: ProteinReference
xref: Reference/UniProt P30520
organism: Homo sapiens

Compound/PW C000936 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Inosine-5'-monophosphate dehydrogenase 1
type: ProteinReference
xref: Reference/UniProt P20839
organism: Homo sapiens

Bifunctional purine biosynthesis protein PURH
type: ProteinReference
xref: Reference/UniProt P31939
organism: Homo sapiens

ChemicalStructure/PW C000203
type: ChemicalStructure
structure format: SMILES

Ectonucleoside triphosphate diphosphohydrolase 5
type: ProteinReference
xref: Reference/UniProt O75356
organism: Homo sapiens

Protein/2368 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Cytosolic purine 5'-nucleotidase
stoichiometric coefficient: 4.0

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

Reference/HMDB HMDB0000536
type: UnificationXref
id: HMDB0000536
db: HMDB

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Adenosine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 60961
xref: Reference/ChEBI CHEBI 16335
xref: Reference/ChemSpider 54923
xref: Reference/HMDB HMDB0000050
xref: Reference/CAS 58-61-7
xref: Reference/KEGG Compound C00212
xref: Reference/BioCyc ADENOSINE
chemical formula: C10H13N5O4
molecular weight: 267.09674
structure: ChemicalStructure/PW C000034

Protein/713 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Deoxyguanosine kinase, mitochondrial
stoichiometric coefficient: 2.0

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Compound/PW C000086 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanine
stoichiometric coefficient: 1.0

2'-Deoxyguanosine 5'-monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 2'-Deoxyguanosine 5'-monophosphate

Thioredoxin
type: ProteinReference
xref: Reference/UniProt P10599
organism: Homo sapiens

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 165388
xref: Reference/BioCyc PHOSPHORIBOSYL-CARBOXY-AMINOIMIDAZOLE
xref: Reference/ChEBI CHEBI 28413
xref: Reference/HMDB HMDB0006273
xref: Reference/KEGG Compound C04751
xref: Reference/ChemSpider 144983
chemical formula: C9H14N3O9P
molecular weight: 339.04675
structure: ChemicalStructure/PW C002699

Multifunctional protein ADE2
type: ProteinReference
xref: Reference/UniProt P22234
organism: Homo sapiens

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

Reference/UniProt P23109
type: UnificationXref
id: P23109
db: UniProt

GMP synthase [glutamine-hydrolyzing]
type: Complex
component stoichiometry: Protein/560 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: GMP synthase [glutamine-hydrolyzing]

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/ChEBI CHEBI 37737
type: UnificationXref
id: CHEBI:37737
db: ChEBI

Guanosine 2',3'-cyclic phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine 2',3'-cyclic phosphate

GMP synthase [glutamine-hydrolyzing]
type: Protein
cellular location: Cytoplasm
entity reference: GMP synthase [glutamine-hydrolyzing]

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/UniProt P00491
type: UnificationXref
id: P00491
db: UniProt

Reference/UniProt P00492
type: UnificationXref
id: P00492
db: UniProt

Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Phosphoribosyl pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphoribosyl pyrophosphate
name: SubPathwayOutput

cAMP-specific 3',5'-cyclic phosphodiesterase 4D
type: ProteinReference
xref: Reference/UniProt Q08499
organism: Homo sapiens

Protein/825 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Bifunctional purine biosynthesis protein PURH
stoichiometric coefficient: 2.0

Reference/CAS 2793-06-8
type: UnificationXref
id: 2793-06-8
db: CAS

Protein/594 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: ADP-sugar pyrophosphatase
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 2030
type: UnificationXref
id: CHEBI:2030
db: ChEBI

Reference/CAS 3031-95-6
type: UnificationXref
id: 3031-95-6
db: CAS

Reference/UniProt Q02153
type: UnificationXref
id: Q02153
db: UniProt

Reference/HMDB HMDB0000797
type: UnificationXref
id: HMDB0000797
db: HMDB

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Phosphoribosylformylglycinamidine synthase
type: Protein
cellular location: Cytoplasm
entity reference: Phosphoribosylformylglycinamidine synthase

Reference/CAS 634-02-6
type: UnificationXref
id: 634-02-6
db: CAS

Xanthine dehydrogenase/oxidase
type: Complex
component stoichiometry: Protein/176 Peroxisome/Stoichiometry/2.0
cellular location: Peroxisome
component: Xanthine dehydrogenase/oxidase

Multifunctional protein ADE2
type: Protein
cellular location: Cytoplasm
entity reference: Multifunctional protein ADE2

Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phosphate

Reference/UniProt Q16774
type: UnificationXref
id: Q16774
db: UniProt

Ribose-phosphate pyrophosphokinase 3
type: Protein
cellular location: Cytoplasm
entity reference: Ribose-phosphate pyrophosphokinase 3

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Guanylate cyclase soluble subunit alpha-2
type: Protein
cellular location: Cytoplasm
entity reference: Guanylate cyclase soluble subunit alpha-2

Compound/PW C000822 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2'-Deoxyguanosine 5'-monophosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Adenosine triphosphate

Phosphoribosyl formamidocarboxamide
type: SmallMoleculeReference
xref: Reference/ChemSpider 145893
xref: Reference/BioCyc PHOSPHORIBOSYL-FORMAMIDO-CARBOXAMIDE
xref: Reference/ChEBI CHEBI 18381
xref: Reference/HMDB HMDB0001439
xref: Reference/KEGG Compound C04734
xref: Reference/PubChem-compound 166760
chemical formula: C10H15N4O9P
molecular weight: 366.05768
structure: ChemicalStructure/PW C001111

dGTP
type: SmallMoleculeReference
xref: Reference/BioCyc DGTP
xref: Reference/ChemSpider 58613
xref: Reference/CAS 2564-35-4
xref: Reference/PubChem-compound 65103
xref: Reference/KEGG Compound C00286
xref: Reference/ChEBI CHEBI 16497
xref: Reference/HMDB HMDB0001440
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C001112

Glycineamideribotide
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03838
xref: Reference/ChemSpider 141370
xref: Reference/ChEBI CHEBI 18349
xref: Reference/CAS 10074-18-7
xref: Reference/PubChem-compound 160913
xref: Reference/BioCyc 5-PHOSPHO-RIBOSYL-GLYCINEAMIDE
xref: Reference/HMDB HMDB0002022
chemical formula: C7H15N2O8P
molecular weight: 286.0566
structure: ChemicalStructure/PW C001355

3.5.4.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000198 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000086 Cytoplasm/Stoichiometry/1.0
right: Ammonia
right: Xanthine
spontaneous: false
EC number: 3.5.4.3
left: Water
left: Guanine
name: Guanine + Water → Ammonia + Xanthine
conversion direction: LEFT_TO_RIGHT

Adenine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000034
xref: Reference/BioCyc ADENINE
xref: Reference/PubChem-compound 190
xref: Reference/ChemSpider 185
xref: Reference/KEGG Compound C00147
xref: Reference/ChEBI CHEBI 16708
xref: Reference/CAS 73-24-5
chemical formula: C5H5N5
molecular weight: 135.05449
structure: ChemicalStructure/PW C000024

Compound/PW C001168 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: AICAR
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Diguanosine tetraphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Diguanosine tetraphosphate

Deoxyguanosine kinase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Deoxyguanosine kinase, mitochondrial

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/ChemSpider 141175
type: UnificationXref
id: 141175
db: ChemSpider

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/ChEBI CHEBI 28843
type: UnificationXref
id: CHEBI:28843
db: ChEBI

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

AICAR
type: SmallMoleculeReference
xref: Reference/CAS 3031-94-5
xref: Reference/ChemSpider 58620
xref: Reference/ChEBI CHEBI 18406
xref: Reference/HMDB HMDB0001517
xref: Reference/KEGG Compound C04677
xref: Reference/PubChem-compound 65110
xref: Reference/BioCyc AICAR
chemical formula: C9H15N4O8P
molecular weight: 338.06274
structure: ChemicalStructure/PW C001168

Glycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000123
xref: Reference/BioCyc GLY
xref: Reference/ChemSpider 730
xref: Reference/PubChem-compound 5257127
xref: Reference/CAS 56-40-6
xref: Reference/ChEBI CHEBI 15428
xref: Reference/KEGG Compound C00037
chemical formula: C2H5NO2
molecular weight: 75.03203
structure: ChemicalStructure/PW C000078

dADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00206
xref: Reference/PubChem-compound 53477733
xref: Reference/HMDB HMDB0001508
xref: Reference/CAS 2793-06-8
xref: Reference/ChEBI CHEBI 16174
xref: Reference/BioCyc DADP
chemical formula: C10H15N5O9P2
molecular weight: 411.03452
structure: ChemicalStructure/PW C001161

Reference/ChEBI CHEBI 17712
type: UnificationXref
id: CHEBI:17712
db: ChEBI

Reference/ChEBI CHEBI 17713
type: UnificationXref
id: CHEBI:17713
db: ChEBI

Guanylate cyclase soluble subunit alpha-2
type: ProteinReference
xref: Reference/UniProt P33402
organism: Homo sapiens

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/PubChem-compound 790
type: UnificationXref
id: 790
db: PubChem-compound

Guanylate cyclase soluble subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02153
organism: Homo sapiens

Protein/429 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenine phosphoribosyltransferase
stoichiometric coefficient: 2.0

cAMP-specific 3',5'-cyclic phosphodiesterase 4D
type: Protein
cellular location: Cytoplasm
entity reference: cAMP-specific 3',5'-cyclic phosphodiesterase 4D

Ribonucleoside-diphosphate reductase 1
type: Complex
component stoichiometry: Protein/107 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/104 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Ribonucleoside-diphosphate reductase large subunit
component: Ribonucleoside-diphosphate reductase subunit M2

ChemicalStructure/PW C001111
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000101
type: UnificationXref
id: HMDB0000101
db: HMDB

Deoxyadenosine triphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001532
xref: Reference/CAS 1927-31-7
xref: Reference/ChemSpider 15194
xref: Reference/KEGG Compound C00131
xref: Reference/ChEBI CHEBI 16284
xref: Reference/PubChem-compound 15993
xref: Reference/BioCyc DATP
chemical formula: C10H16N5O12P3
molecular weight: 491.00082
structure: ChemicalStructure/PW C001177

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Reference/BioCyc 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE
type: UnificationXref
id: 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE
db: BioCyc

ChemicalStructure/PW C001355
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000024
type: ChemicalStructure
structure format: SMILES
structure data: NC1=C2NC=NC2=NC=N1

ChemicalStructure/PW C001112
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C04051
type: UnificationXref
id: C04051
db: KEGG Compound

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

Guanosine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000133
xref: Reference/BioCyc GUANOSINE
xref: Reference/CAS 118-00-3
xref: Reference/ChemSpider 6544
xref: Reference/PubChem-compound 6802
xref: Reference/ChEBI CHEBI 16750
xref: Reference/KEGG Compound C00387
chemical formula: C10H13N5O5
molecular weight: 283.09167
structure: ChemicalStructure/PW C000087

Guanine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 764
xref: Reference/ChEBI CHEBI 16235
xref: Reference/CAS 73-40-5
xref: Reference/BioCyc GUANINE
xref: Reference/KEGG Compound C00242
xref: Reference/HMDB HMDB0000132
xref: Reference/ChemSpider 744
chemical formula: C5H5N5O
molecular weight: 151.04941
structure: ChemicalStructure/PW C000086

Reference/BioCyc GUANINE
type: UnificationXref
id: GUANINE
db: BioCyc

Reference/PubChem-compound 65059
type: UnificationXref
id: 65059
db: PubChem-compound

Reference/PubChem-compound 65058
type: UnificationXref
id: 65058
db: PubChem-compound

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

Reference/PubChem-compound 6802
type: UnificationXref
id: 6802
db: PubChem-compound

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/HMDB HMDB0001439
type: UnificationXref
id: HMDB0001439
db: HMDB

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Deoxyinosine
type: SmallMoleculeReference
xref: Reference/ChemSpider 58569
xref: Reference/ChEBI CHEBI 28997
xref: Reference/CAS 890-38-0
xref: Reference/PubChem-compound 65058
xref: Reference/HMDB HMDB0000071
xref: Reference/KEGG Compound C05512
xref: Reference/BioCyc DEOXYINOSINE
chemical formula: C10H12N4O4
molecular weight: 252.08586
structure: ChemicalStructure/PW C000050

Reference/UniProt P47989
type: UnificationXref
id: P47989
db: UniProt

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/ChemSpider 15194
type: UnificationXref
id: 15194
db: ChemSpider

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/CAS 3493-09-2
type: UnificationXref
id: 3493-09-2
db: CAS

Ribose 1-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 14075-00-4
xref: Reference/ChEBI CHEBI 16300
xref: Reference/HMDB HMDB0001489
xref: Reference/PubChem-compound 439236
xref: Reference/ChemSpider 388373
xref: Reference/BioCyc RIBOSE-1P
xref: Reference/KEGG Compound C00620
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C001146

Reference/PubChem-compound 6804
type: UnificationXref
id: 6804
db: PubChem-compound

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Deoxyguanosine
type: SmallMoleculeReference
xref: Reference/BioCyc DEOXYGUANOSINE
xref: Reference/PubChem-compound 187790
xref: Reference/CAS 961-07-9
xref: Reference/KEGG Compound C00330
xref: Reference/ChEBI CHEBI 17172
xref: Reference/ChemSpider 163230
xref: Reference/HMDB HMDB0000085
chemical formula: C10H13N5O4
molecular weight: 267.09674
structure: ChemicalStructure/PW C000058

Compound/PW C000822 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2'-Deoxyguanosine 5'-monophosphate
stoichiometric coefficient: 1.0

Adenylosuccinate synthetase isozyme 2
type: Complex
component stoichiometry: Protein/823 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Adenylosuccinate synthetase isozyme 2

Adenylate cyclase type 2
type: Protein
cellular location: Cytoplasm
entity reference: Adenylate cyclase type 2

Reference/HMDB HMDB0001440
type: UnificationXref
id: HMDB0001440
db: HMDB

Reference/CAS 68-94-0
type: UnificationXref
id: 68-94-0
db: CAS

Deoxyadenosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Deoxyadenosine monophosphate

ADP-sugar pyrophosphatase
type: Protein
cellular location: Cytoplasm
entity reference: ADP-sugar pyrophosphatase

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

Xanthylic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Xanthylic acid

Adenosine Deaminase Deficiency
type: Pathway
pathway order: PathwayEnzymeReaction/946
pathway order: PathwayEnzymeReaction/945
pathway order: PathwayEnzymeReaction/948
pathway order: PathwayEnzymeReaction/942
pathway order: PathwayEnzymeReaction/986
pathway order: PathwayEnzymeReaction/985
pathway order: PathwayEnzymeReaction/982
pathway order: PathwayEnzymeReaction/981
pathway order: PathwayEnzymeReaction/3398
pathway order: PathwayEnzymeReaction/940
pathway order: PathwayEnzymeReaction/984
pathway order: PathwayEnzymeReaction/983
pathway order: PathwayEnzymeReaction/980
pathway order: PathwayEnzymeReaction/1011
pathway order: PathwayEnzymeReaction/1006
pathway order: PathwayEnzymeReaction/1004
pathway order: PathwayEnzymeReaction/1003
pathway order: PathwayEnzymeReaction/1008
pathway order: PathwayEnzymeReaction/956
pathway order: PathwayEnzymeReaction/953
pathway order: PathwayEnzymeReaction/996
pathway order: PathwayEnzymeReaction/999
pathway order: PathwayEnzymeReaction/992
pathway order: PathwayEnzymeReaction/951
pathway order: PathwayEnzymeReaction/995
pathway order: PathwayEnzymeReaction/950
pathway order: PathwayEnzymeReaction/994
pathway order: PathwayEnzymeReaction/991
pathway order: PathwayEnzymeReaction/1022
pathway order: PathwayEnzymeReaction/1017
pathway order: PathwayEnzymeReaction/1014
pathway order: PathwayEnzymeReaction/1019
pathway order: PathwayEnzymeReaction/949
pathway order: PathwayEnzymeReaction/968
pathway order: PathwayEnzymeReaction/967
pathway order: PathwayEnzymeReaction/964
pathway order: PathwayEnzymeReaction/963
pathway order: PathwaySubPathway/132
pathway order: PathwayEnzymeReaction/922
pathway order: PathwayEnzymeReaction/966
pathway order: PathwayEnzymeReaction/888
pathway order: PathwayEnzymeReaction/965
pathway order: PathwayEnzymeReaction/1031
pathway order: PathwayEnzymeReaction/1030
pathway order: PathwayEnzymeReaction/1035
pathway order: PathwayEnzymeReaction/1034
pathway order: PathwayEnzymeReaction/1033
pathway order: PathwayEnzymeReaction/1032
pathway order: PathwayEnzymeReaction/1025
pathway order: PathwayEnzymeReaction/3401
pathway order: PathwayEnzymeReaction/3402
pathway order: PathwayEnzymeReaction/3403
pathway order: PathwayEnzymeReaction/917
pathway order: PathwayEnzymeReaction/919
pathway order: PathwayEnzymeReaction/918
pathway order: PathwayEnzymeReaction/979
pathway order: PathwayEnzymeReaction/978
pathway order: PathwayEnzymeReaction/975
pathway order: PathwayEnzymeReaction/974
pathway order: PathwayEnzymeReaction/971
pathway order: PathwayEnzymeReaction/970
pathway order: PathwayEnzymeReaction/973
pathway order: PathwayEnzymeReaction/972
pathway order: PathwayEnzymeReaction/1039
pathway order: PathwayEnzymeReaction/1038
pathway order: PathwayEnzymeReaction/1037
pathway order: PathwayEnzymeReaction/1036
pathway component: ReactionCatalysis17
pathway component: ReactionCatalysis790
pathway component: 3.6.1.5
pathway component: 2.4.2.7
pathway component: Pentose Phosphate Pathway
pathway component: 3.6.1.19
pathway component: 2.7.4.6
pathway component: Reaction1093
pathway component: ReactionCatalysis788
pathway component: Reaction354

Reference/HMDB HMDB0000123
type: UnificationXref
id: HMDB0000123
db: HMDB

Adenylate kinase isoenzyme 1
type: Protein
cellular location: Cytoplasm
entity reference: Adenylate kinase isoenzyme 1

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Reference/UniProt P22234
type: UnificationXref
id: P22234
db: UniProt

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Protein/537 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ribose-phosphate pyrophosphokinase 3
stoichiometric coefficient: 2.0

Deoxyadenosine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000101
xref: Reference/KEGG Compound C00559
xref: Reference/PubChem-compound 13730
xref: Reference/CAS 958-09-8
xref: Reference/ChemSpider 13135
xref: Reference/ChEBI CHEBI 17256
chemical formula: C10H13N5O3
molecular weight: 251.10184
structure: ChemicalStructure/PW C000068

Bifunctional purine biosynthesis protein PURH
type: Complex
component stoichiometry: Protein/825 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Bifunctional purine biosynthesis protein PURH

Purine nucleoside phosphorylase
type: ProteinReference
xref: Reference/UniProt P00491
organism: Homo sapiens

Cytosolic purine 5'-nucleotidase
type: ProteinReference
xref: Reference/UniProt P49902
organism: Homo sapiens

Reference/UniProt Q9BY32
type: UnificationXref
id: Q9BY32
db: UniProt

NADH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADH

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/UniProt P49902
type: UnificationXref
id: P49902
db: UniProt

Reference/ChEBI CHEBI 52742
type: UnificationXref
id: CHEBI:52742
db: ChEBI

Protein/5803 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thioredoxin
stoichiometric coefficient: 1.0

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Adenine phosphoribosyltransferase
type: Complex
component stoichiometry: Protein/429 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Adenine phosphoribosyltransferase

Reaction354
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine diphosphate
spontaneous: false
left: Adenosine monophosphate
left: Adenosine triphosphate
name: Adenosine monophosphate + Adenosine triphosphate → 2 Adenosine diphosphate
conversion direction: LEFT_TO_RIGHT

4.6.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000041 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: cAMP
right: Pyrophosphate
spontaneous: false
EC number: 4.6.1.1
left: Adenosine triphosphate
name: Adenosine triphosphate → Pyrophosphate + cAMP
conversion direction: LEFT_TO_RIGHT

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Compound/PW C000955 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Aminoimidazole ribonucleotide
stoichiometric coefficient: 1.0

2.7.4.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001080 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Adenosine diphosphate
right: Guanosine diphosphate
spontaneous: false
EC number: 2.7.4.8
left: Guanosine monophosphate
left: Adenosine triphosphate
name: Adenosine triphosphate + Guanosine monophosphate ↔ Adenosine diphosphate + Guanosine diphosphate
conversion direction: REVERSIBLE

Oxygen
type: SmallMolecule
cellular location: Peroxisome
entity reference: Oxygen

Reference/UniProt P49915
type: UnificationXref
id: P49915
db: UniProt

Protein/458 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Hypoxanthine-guanine phosphoribosyltransferase
stoichiometric coefficient: 4.0

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Water

Inosine triphosphate pyrophosphatase
type: Protein
cellular location: Cytoplasm
entity reference: Inosine triphosphate pyrophosphatase

Compound/PW C000721 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Compound/PW C000034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine
stoichiometric coefficient: 1.0

ReactionCatalysis655
type: Catalysis
controller: Ectonucleoside triphosphate diphosphohydrolase 8
controlled: 3.6.1.5
control type: ACTIVATION

Ribose 1-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Ribose 1-phosphate

ReactionCatalysis697
type: Catalysis
controller: Guanylate kinase
controlled: 2.7.4.8
control type: ACTIVATION

ReactionCatalysis695
type: Catalysis
controller: Ectonucleoside triphosphate diphosphohydrolase 5
controlled: Reaction186
control type: ACTIVATION

Compound/PW C001177 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyadenosine triphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000822
type: ChemicalStructure
structure format: SMILES

Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Guanosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine diphosphate

Reference/ChEBI CHEBI 28862
type: UnificationXref
id: CHEBI:28862
db: ChEBI

5-Aminoimidazole-4-carboxamide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5-Aminoimidazole-4-carboxamide

Reference/BioCyc INOSINE
type: UnificationXref
id: INOSINE
db: BioCyc

Compound/PW C000724 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyadenosine monophosphate
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Compound/PW C000190 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl pyrophosphate
stoichiometric coefficient: 1.0

Compound/PW C001042 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyribose 1-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 6544
type: UnificationXref
id: 6544
db: ChemSpider

Compound/PW C001161 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: dADP
stoichiometric coefficient: 1.0

Reference/ChemSpider 6545
type: UnificationXref
id: 6545
db: ChemSpider

Phosphoric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphoric acid

Phosphoric acid
type: SmallMolecule
cellular location: Peroxisome
entity reference: Phosphoric acid

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Xanthylic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15652
xref: Reference/PubChem-compound 73323
xref: Reference/HMDB HMDB0001554
xref: Reference/KEGG Compound C00655
xref: Reference/ChemSpider 66054
xref: Reference/CAS 523-98-8
xref: Reference/BioCyc XANTHOSINE-5-PHOSPHATE
chemical formula: C10H13N4O9P
molecular weight: 364.04202
structure: ChemicalStructure/PW C001196

Reference/HMDB HMDB0000960
type: UnificationXref
id: HMDB0000960
db: HMDB

Reference/GENE ONTOLOGY GO 0005777
type: UnificationXref
id: GO:0005777
db: GENE ONTOLOGY

Protein/422 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Inosine triphosphate pyrophosphatase
stoichiometric coefficient: 2.0

D-Ribose 5-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00117
xref: Reference/ChEBI CHEBI 52742
xref: Reference/ChemSpider 388313
xref: Reference/HMDB HMDB0001548
xref: Reference/BioCyc RIBOSE-5P
xref: Reference/PubChem-compound 439167
xref: Reference/CAS 4300-28-1
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C001191

3.5.4.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000114 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Inosinic acid
right: Ammonia
spontaneous: false
EC number: 3.5.4.6
left: Adenosine monophosphate
left: Water
name: Adenosine monophosphate + Water ↔ Ammonia + Inosinic acid
conversion direction: REVERSIBLE

Hypoxanthine-guanine phosphoribosyltransferase
type: Complex
component stoichiometry: Protein/458 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Hypoxanthine-guanine phosphoribosyltransferase

Reference/UniProt P21108
type: UnificationXref
id: P21108
db: UniProt

Thioredoxin
type: Protein
cellular location: Cytosol
entity reference: Thioredoxin

Reference/SMPDB SMP0000031
type: UnificationXref
id: SMP0000031
db: SMPDB

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Compound/PW C001177 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyadenosine triphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0006273
type: UnificationXref
id: HMDB0006273
db: HMDB

Compound/PW C000032 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1175
type: UnificationXref
id: 1175
db: PubChem-compound

Compound/PW C000637 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: SAICAR
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000972
type: UnificationXref
id: HMDB0000972
db: HMDB

Amidophosphoribosyltransferase
type: Complex
component stoichiometry: Protein/325 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Amidophosphoribosyltransferase

Compound/PW C000058 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyguanosine
stoichiometric coefficient: 1.0

Reference/BioCyc ADENOSINE
type: UnificationXref
id: ADENOSINE
db: BioCyc

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Guanine deaminase
type: Protein
cellular location: Cytoplasm
entity reference: Guanine deaminase

Reference/ChEBI CHEBI 18406
type: UnificationXref
id: CHEBI:18406
db: ChEBI

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

GMP reductase 1
type: Complex
component stoichiometry: Protein/649 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: GMP reductase 1

ChemicalStructure/PW C000413
type: ChemicalStructure
structure format: SMILES

Compound/PW C000078 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

Compound/PW C000414 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Adenosine diphosphate ribose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001178
xref: Reference/ChEBI CHEBI 16960
xref: Reference/BioCyc ADENOSINE DIPHOSPHATE RIBOSE
xref: Reference/PubChem-compound 192
xref: Reference/ChemSpider 187
xref: Reference/CAS 20762-30-5
xref: Reference/KEGG Compound C00301
chemical formula: C15H23N5O14P2
molecular weight: 559.07166
structure: ChemicalStructure/PW C000914

Reference/HMDB HMDB0011629
type: UnificationXref
id: HMDB0011629
db: HMDB

ReactionCatalysis698
type: Catalysis
controller: Ribose-phosphate pyrophosphokinase 3
controlled: 2.7.6.1
control type: ACTIVATION

Reaction579
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001144 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000195 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000198 Peroxisome/Stoichiometry/1.0
right: NADH
right: Uric acid
spontaneous: false
left: Xanthine
left: Water
left: NAD
name: NAD + Water + Xanthine → NADH + Uric acid
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 388373
type: UnificationXref
id: 388373
db: ChemSpider

Reference/CAS 69-89-6
type: UnificationXref
id: 69-89-6
db: CAS

Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/ChemSpider 7830994
type: UnificationXref
id: 7830994
db: ChemSpider

Reference/BioCyc PRPP
type: UnificationXref
id: PRPP
db: BioCyc

Reference/PubChem-compound 440122
type: UnificationXref
id: 440122
db: PubChem-compound

Reference/PubChem-compound 192
type: UnificationXref
id: 192
db: PubChem-compound

Reference/PubChem-compound 190
type: UnificationXref
id: 190
db: PubChem-compound

1.1.1.205
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000114 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001196 Cytoplasm/Stoichiometry/1.0
right: NADH
right: Xanthylic acid
spontaneous: false
EC number: 1.1.1.205
left: Inosinic acid
left: Water
left: NAD
name: Inosinic acid + NAD + Water → NADH + Xanthylic acid
conversion direction: LEFT_TO_RIGHT

Reaction578
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000198 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000102 Peroxisome/Stoichiometry/1.0
right: Xanthine
right: Hydrogen peroxide
spontaneous: false
left: Hypoxanthine
left: Oxygen
left: Water
name: Hypoxanthine + Oxygen + Water → Hydrogen peroxide + Xanthine
conversion direction: LEFT_TO_RIGHT

Protein/623 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: AMP deaminase 1
stoichiometric coefficient: 4.0

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Reference/UniProt P31350
type: UnificationXref
id: P31350
db: UniProt

Compound/PW C000767 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dGDP
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17775
type: UnificationXref
id: CHEBI:17775
db: ChEBI

Reference/CAS 523-98-8
type: UnificationXref
id: 523-98-8
db: CAS

SAICAR
type: SmallMolecule
cellular location: Cytoplasm
entity reference: SAICAR

Reference/ChemSpider 109092
type: UnificationXref
id: 109092
db: ChemSpider

Reference/HMDB HMDB0001846
type: UnificationXref
id: HMDB0001846
db: HMDB

Reference/HMDB HMDB0000999
type: UnificationXref
id: HMDB0000999
db: HMDB

Reference/KEGG Compound C00301
type: UnificationXref
id: C00301
db: KEGG Compound

ChemicalStructure/PW C000637
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 1188
type: UnificationXref
id: 1188
db: PubChem-compound

Inosine-5'-monophosphate dehydrogenase 1
type: Complex
component stoichiometry: Protein/826 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Inosine-5'-monophosphate dehydrogenase 1

Reference/ChEBI CHEBI 28413
type: UnificationXref
id: CHEBI:28413
db: ChEBI

Compound/PW C001065 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000882
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-609
type: UnificationXref
id: CPD-609
db: BioCyc

Reference/KEGG Compound C00559
type: UnificationXref
id: C00559
db: KEGG Compound

Reference/ChemSpider 388359
type: UnificationXref
id: 388359
db: ChemSpider

Reference/PubChem-compound 6021
type: UnificationXref
id: 6021
db: PubChem-compound

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/ChEBI CHEBI 18319
type: UnificationXref
id: CHEBI:18319
db: ChEBI

Reference/UniProt P30566
type: UnificationXref
id: P30566
db: UniProt

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

L-Aspartic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Aspartic acid

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

Reference/BioCyc 10-FORMYL-THF
type: UnificationXref
id: 10-FORMYL-THF
db: BioCyc

Compound/PW C000955 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Aminoimidazole ribonucleotide
stoichiometric coefficient: 1.0

ReactionCatalysis701
type: Catalysis
controller: Ribonucleoside-diphosphate reductase 1
controlled: 1.17.4.1
control type: ACTIVATION

Reference/KEGG Compound C03838
type: UnificationXref
id: C03838
db: KEGG Compound

Reference/CAS 85-32-5
type: UnificationXref
id: 85-32-5
db: CAS

5-Aminoimidazole ribonucleotide
type: SmallMoleculeReference
xref: Reference/KEGG Compound C03373
xref: Reference/HMDB HMDB0001235
xref: Reference/ChEBI CHEBI 28843
xref: Reference/ChemSpider 141854
xref: Reference/CAS 25635-88-5
xref: Reference/PubChem-compound 161500
xref: Reference/BioCyc 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL
chemical formula: C8H14N3O7P
molecular weight: 295.05695
structure: ChemicalStructure/PW C000955

Reference/PathWhiz PW000055
type: UnificationXref
id: PW000055
db: PathWhiz

Reference/UniProt Q08499
type: UnificationXref
id: Q08499
db: UniProt

Adenosine deaminase
type: Protein
cellular location: Cytoplasm
entity reference: Adenosine deaminase

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

5-Aminoimidazole-4-carboxamide
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-3762
xref: Reference/ChEBI CHEBI 2030
xref: Reference/ChemSpider 9298
xref: Reference/PubChem-compound 9679
xref: Reference/HMDB HMDB0003192
xref: Reference/KEGG Compound C04051
xref: Reference/CAS 360-97-4
chemical formula: C4H6N4O
molecular weight: 126.05416
structure: ChemicalStructure/PW C001801

Adenine phosphoribosyltransferase
type: Protein
cellular location: Cytoplasm
entity reference: Adenine phosphoribosyltransferase

Reference/ChemSpider 18714427
type: UnificationXref
id: 18714427
db: ChemSpider

AMP deaminase 1
type: Complex
component stoichiometry: Protein/623 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: AMP deaminase 1

ReactionCatalysis730
type: Catalysis
controller: Phosphoribosylformylglycinamidine synthase
controlled: 6.3.5.3
control type: ACTIVATION

Reference/ChEBI CHEBI 17202
type: UnificationXref
id: CHEBI:17202
db: ChEBI

Reference/UniProt Q08462
type: UnificationXref
id: Q08462
db: UniProt

Multifunctional protein ADE2
type: Complex
component stoichiometry: Protein/837 Cytoplasm/Stoichiometry/8.0
cellular location: Cytoplasm
component: Multifunctional protein ADE2

Reference/ChemSpider 58484
type: UnificationXref
id: 58484
db: ChemSpider

Adenosine diphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Adenosine diphosphate

Reference/KEGG Compound C00330
type: UnificationXref
id: C00330
db: KEGG Compound

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Guanosine monophosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Guanosine monophosphate

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

ReactionCatalysis728
type: Catalysis
controller: Trifunctional purine biosynthetic protein adenosine-3
controlled: Reaction483
control type: ACTIVATION

ReactionCatalysis729
type: Catalysis
controller: Trifunctional purine biosynthetic protein adenosine-3
controlled: Reaction1065
control type: ACTIVATION

ReactionCatalysis726
type: Catalysis
controller: ADP-sugar pyrophosphatase
controlled: Reaction1064
control type: ACTIVATION

ReactionCatalysis725
type: Catalysis
controller: Guanine deaminase
controlled: 3.5.4.3
control type: ACTIVATION

ReactionCatalysis722
type: Catalysis
controller: Purine nucleoside phosphorylase
controlled: 2.4.2.1
control type: ACTIVATION

Reference/BioCyc HYPOXANTHINE
type: UnificationXref
id: HYPOXANTHINE
db: BioCyc

ReactionCatalysis720
type: Catalysis
controller: Cytosolic purine 5'-nucleotidase
controlled: 3.1.3.5
control type: ACTIVATION

Reference/BioCyc XANTHINE
type: UnificationXref
id: XANTHINE
db: BioCyc

ReactionCatalysis721
type: Catalysis
controller: Purine nucleoside phosphorylase
controlled: 2.4.2.1
control type: ACTIVATION

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine monophosphate

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Reference/KEGG Compound C00104
type: UnificationXref
id: C00104
db: KEGG Compound

Reference/PubChem-compound 12599
type: UnificationXref
id: 12599
db: PubChem-compound

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Reference/KEGG Compound C00101
type: UnificationXref
id: C00101
db: KEGG Compound

Reference/CAS 10074-18-7
type: UnificationXref
id: 10074-18-7
db: CAS

ReactionCatalysis719
type: Catalysis
controller: Hypoxanthine-guanine phosphoribosyltransferase
controlled: 2.4.2.7
control type: ACTIVATION

ReactionCatalysis718
type: Catalysis
controller: Adenine phosphoribosyltransferase
controlled: 2.4.2.7
control type: ACTIVATION

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/PubChem-compound 439287
type: UnificationXref
id: 439287
db: PubChem-compound

ReactionCatalysis715
type: Catalysis
controller: Cytosolic purine 5'-nucleotidase
controlled: 3.1.3.5
control type: ACTIVATION

ReactionCatalysis716
type: Catalysis
controller: Deoxyguanosine kinase
controlled: 2.7.1.113
control type: ACTIVATION

ReactionCatalysis712
type: Catalysis
controller: Guanylate kinase
controlled: 2.7.4.8
control type: ACTIVATION

ReactionCatalysis710
type: Catalysis
controller: Nucleoside diphosphate kinase 6
controlled: 2.7.4.6
control type: ACTIVATION

Compound/PW C000414 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00119
type: UnificationXref
id: C00119
db: KEGG Compound

ReactionCatalysis751
type: Catalysis
controller: Xanthine dehydrogenase/oxidase
controlled: Reaction578
control type: ACTIVATION

ReactionCatalysis752
type: Catalysis
controller: Xanthine dehydrogenase/oxidase
controlled: Reaction579
control type: ACTIVATION

Reference/KEGG Compound C00117
type: UnificationXref
id: C00117
db: KEGG Compound

Reference/ChemSpider 388313
type: UnificationXref
id: 388313
db: ChemSpider

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Water
type: SmallMolecule
cellular location: Peroxisome
entity reference: Water

Reference/UniProt P07741
type: UnificationXref
id: P07741
db: UniProt

Reference/UniProt P30520
type: UnificationXref
id: P30520
db: UniProt

Reference/ChEBI CHEBI 16174
type: UnificationXref
id: CHEBI:16174
db: ChEBI

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Amidophosphoribosyltransferase
type: Protein
cellular location: Cytoplasm
entity reference: Amidophosphoribosyltransferase

2.7.4.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000767 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000822 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Adenosine diphosphate
right: dGDP
spontaneous: false
EC number: 2.7.4.8
left: 2'-Deoxyguanosine 5'-monophosphate
left: Adenosine triphosphate
name: 2'-Deoxyguanosine 5'-monophosphate + Adenosine triphosphate ↔ Adenosine diphosphate + dGDP
conversion direction: REVERSIBLE

Reference/KEGG Compound C00360
type: UnificationXref
id: C00360
db: KEGG Compound

Reference/ChemSpider 141854
type: UnificationXref
id: 141854
db: ChemSpider

Reference/PubChem-compound 122347
type: UnificationXref
id: 122347
db: PubChem-compound

ReactionCatalysis746
type: Catalysis
controller: Purine nucleoside phosphorylase
controlled: 2.4.2.1
control type: ACTIVATION

ReactionCatalysis747
type: Catalysis
controller: Hypoxanthine-guanine phosphoribosyltransferase
controlled: 2.4.2.8
control type: ACTIVATION

ReactionCatalysis744
type: Catalysis
controller: Cytosolic purine 5'-nucleotidase
controlled: 3.1.3.5
control type: ACTIVATION

ReactionCatalysis745
type: Catalysis
controller: Hypoxanthine-guanine phosphoribosyltransferase
controlled: 2.4.2.8
control type: ACTIVATION

ReactionCatalysis742
type: Catalysis
controller: Cytosolic purine 5'-nucleotidase
controlled: 3.1.3.5
control type: ACTIVATION

ReactionCatalysis743
type: Catalysis
controller: Purine nucleoside phosphorylase
controlled: 2.4.2.1
control type: ACTIVATION

Reference/UniProt O75414
type: UnificationXref
id: O75414
db: UniProt

ReactionCatalysis740
type: Catalysis
controller: Inosine-5'-monophosphate dehydrogenase 1
controlled: 1.1.1.205
control type: ACTIVATION

ReactionCatalysis741
type: Catalysis
controller: GMP reductase 1
controlled: 1.7.1.7
control type: ACTIVATION

Reference/BioCyc ADENINE
type: UnificationXref
id: ADENINE
db: BioCyc

Reference/PubChem-compound 53477733
type: UnificationXref
id: 53477733
db: PubChem-compound

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

Reference/KEGG Compound C00362
type: UnificationXref
id: C00362
db: KEGG Compound

Reference/KEGG Compound C00361
type: UnificationXref
id: C00361
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/BioCyc DEOXY-RIBOSE-1P
type: UnificationXref
id: DEOXY-RIBOSE-1P
db: BioCyc

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

IDP
type: SmallMoleculeReference
xref: Reference/ChemSpider 559208
xref: Reference/HMDB HMDB0003335
xref: Reference/CAS 86-04-4
xref: Reference/BioCyc IDP
xref: Reference/PubChem-compound 644173
xref: Reference/KEGG Compound C00104
xref: Reference/ChEBI CHEBI 17808
chemical formula: C10H14N4O11P2
molecular weight: 428.01343
structure: ChemicalStructure/PW C001846

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00366
type: UnificationXref
id: C00366
db: KEGG Compound

Reference/PubChem-compound 73323
type: UnificationXref
id: 73323
db: PubChem-compound

Fumaric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Fumaric acid

2.7.6.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001191 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000190 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: Phosphoribosyl pyrophosphate
spontaneous: false
EC number: 2.7.6.1
left: Adenosine triphosphate
left: D-Ribose 5-phosphate
name: Adenosine triphosphate + D-Ribose 5-phosphate ↔ Adenosine monophosphate + Phosphoribosyl pyrophosphate
conversion direction: REVERSIBLE

Reference/ChemSpider 66054
type: UnificationXref
id: 66054
db: ChemSpider

ReactionCatalysis739
type: Catalysis
controller: GMP synthase [glutamine-hydrolyzing]
controlled: 6.3.5.2
control type: ACTIVATION

ReactionCatalysis737
type: Catalysis
controller: Inosine triphosphate pyrophosphatase
controlled: 3.6.1.19
control type: ACTIVATION

Reference/CAS 37721-04-3
type: UnificationXref
id: 37721-04-3
db: CAS

ReactionCatalysis735
type: Catalysis
controller: Bifunctional purine biosynthesis protein PURH
controlled: Reaction1066
control type: ACTIVATION

ReactionCatalysis736
type: Catalysis
controller: Bifunctional purine biosynthesis protein PURH
controlled: Reaction490
control type: ACTIVATION

ReactionCatalysis733
type: Catalysis
controller: Multifunctional protein ADE2
controlled: Reaction487
control type: ACTIVATION

ReactionCatalysis734
type: Catalysis
controller: Adenylosuccinate lyase
controlled: 4.3.2.2
control type: ACTIVATION

Protein/104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribonucleoside-diphosphate reductase large subunit
stoichiometric coefficient: 1.0

Compound/PW C001112 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: dGTP
stoichiometric coefficient: 1.0

ReactionCatalysis731
type: Catalysis
controller: Trifunctional purine biosynthetic protein adenosine-3
controlled: Reaction484
control type: ACTIVATION

1.17.4.1
type: BiochemicalReaction
participant stoichiometry: Protein/5803 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000767 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cytosol/Stoichiometry/1.0
right: Guanosine diphosphate
right: Thioredoxin
spontaneous: false
EC number: 1.17.4.1
left: dGDP
left: Thioredoxin
left: Water
name: Thioredoxin Disulfide + Water + dGDP ↔ Guanosine diphosphate + Thioredoxin
conversion direction: REVERSIBLE

ReactionCatalysis732
type: Catalysis
controller: Multifunctional protein ADE2
controlled: Reaction486
control type: ACTIVATION

ReactionCatalysis773
type: Catalysis
controller: Adenylate kinase isoenzyme 1
controlled: Reaction354
control type: ACTIVATION

Deoxyadenosine monophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00360
xref: Reference/BioCyc DAMP
xref: Reference/ChEBI CHEBI 17713
xref: Reference/ChemSpider 12079
xref: Reference/CAS 653-63-4
xref: Reference/HMDB HMDB0000905
xref: Reference/PubChem-compound 12599
chemical formula: C10H14N5O6P
molecular weight: 331.06818
structure: ChemicalStructure/PW C000724

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

Reference/CAS 118-00-3
type: UnificationXref
id: 118-00-3
db: CAS

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

ReactionCatalysis770
type: Catalysis
controller: Ectonucleoside triphosphate diphosphohydrolase 5
controlled: Reaction250
control type: ACTIVATION

Hydrogen peroxide
type: SmallMolecule
cellular location: Peroxisome
entity reference: Hydrogen peroxide

Reference/PubChem-compound 44367445
type: UnificationXref
id: 44367445
db: PubChem-compound

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

2.4.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001042 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000024 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000068 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
right: Deoxyribose 1-phosphate
right: Adenine
spontaneous: false
EC number: 2.4.2.1
left: Deoxyadenosine
left: Phosphate
name: Deoxyadenosine + Phosphate ↔ Adenine + Deoxyribose 1-phosphate
conversion direction: REVERSIBLE

Reference/PubChem-compound 7339
type: UnificationXref
id: 7339
db: PubChem-compound

Reference/KEGG Compound C00131
type: UnificationXref
id: C00131
db: KEGG Compound

Reference/KEGG Compound C04734
type: UnificationXref
id: C04734
db: KEGG Compound

Reference/KEGG Compound C00130
type: UnificationXref
id: C00130
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/HMDB HMDB0000905
type: UnificationXref
id: HMDB0000905
db: HMDB

Compound/PW C000121 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inosine triphosphate
stoichiometric coefficient: 1.0

2.4.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000050 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000102 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001042 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
right: Deoxyribose 1-phosphate
right: Hypoxanthine
spontaneous: false
EC number: 2.4.2.1
left: Deoxyinosine
left: Phosphate
name: Deoxyinosine + Phosphate ↔ Deoxyribose 1-phosphate + Hypoxanthine
conversion direction: REVERSIBLE

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Guanosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine monophosphate

2.4.2.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000190 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000114 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000102 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
right: Hypoxanthine
right: Phosphoribosyl pyrophosphate
spontaneous: false
EC number: 2.4.2.8
left: Inosinic acid
left: Pyrophosphate
name: Inosinic acid + Pyrophosphate ↔ Hypoxanthine + Phosphoribosyl pyrophosphate
conversion direction: REVERSIBLE

ReactionCatalysis768
type: Catalysis
controller: Adenine phosphoribosyltransferase
controlled: 2.4.2.7
control type: ACTIVATION

ReactionCatalysis767
type: Catalysis
controller: Adenosine deaminase
controlled: 3.5.4.4
control type: ACTIVATION

ReactionCatalysis765
type: Catalysis
controller: Purine nucleoside phosphorylase
controlled: 2.4.2.1
control type: ACTIVATION

SubPathwayInteraction132
type: Interaction
name: SubPathway132Reaction
name: SubPathwayReaction
participant: Phosphoribosyl pyrophosphate

Reference/ChEBI CHEBI 18349
type: UnificationXref
id: CHEBI:18349
db: ChEBI

Reference/ChEBI CHEBI 18107
type: UnificationXref
id: CHEBI:18107
db: ChEBI

ReactionCatalysis763
type: Catalysis
controller: Purine nucleoside phosphorylase
controlled: 2.4.2.1
control type: ACTIVATION

ReactionCatalysis761
type: Catalysis
controller: Adenosine deaminase
controlled: 3.5.4.4
control type: ACTIVATION

Reference/HMDB HMDB0003192
type: UnificationXref
id: HMDB0003192
db: HMDB

Reference/KEGG Compound C00144
type: UnificationXref
id: C00144
db: KEGG Compound

Reference/KEGG Compound C00385
type: UnificationXref
id: C00385
db: KEGG Compound

2.4.2.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000190 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000198 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001196 Cytoplasm/Stoichiometry/1.0
right: Phosphoribosyl pyrophosphate
right: Xanthine
spontaneous: false
EC number: 2.4.2.8
left: Xanthylic acid
left: Pyrophosphate
name: Pyrophosphate + Xanthylic acid ↔ Phosphoribosyl pyrophosphate + Xanthine
conversion direction: REVERSIBLE

Reference/PathWhiz PW000075
type: UnificationXref
id: PW000075
db: PathWhiz

ChemicalStructure/PW C000914
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00147
type: UnificationXref
id: C00147
db: KEGG Compound

Reference/ChEBI CHEBI 17256
type: UnificationXref
id: CHEBI:17256
db: ChEBI

Reference/KEGG Compound C00387
type: UnificationXref
id: C00387
db: KEGG Compound

Reference/BioCyc DGDP
type: UnificationXref
id: DGDP
db: BioCyc

Reaction1066
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000774 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001168 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001111 Cytoplasm/Stoichiometry/1.0
right: Tetrahydrofolic acid
right: Phosphoribosyl formamidocarboxamide
spontaneous: false
left: AICAR
left: 10-Formyltetrahydrofolate
name: 10-Formyltetrahydrofolate + AICAR ↔ Phosphoribosyl formamidocarboxamide + Tetrahydrofolic acid
conversion direction: REVERSIBLE

3.6.1.19
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001080 Cytoplasm/Stoichiometry/1.0
right: Guanosine monophosphate
right: Pyrophosphate
spontaneous: false
EC number: 3.6.1.19
left: Water
left: Guanosine triphosphate
name: Guanosine triphosphate + Water → Guanosine monophosphate + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reaction1064
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001191 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000914 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: D-Ribose 5-phosphate
spontaneous: false
left: Adenosine diphosphate ribose
left: Water
name: Adenosine diphosphate ribose + Water → Adenosine monophosphate + D-Ribose 5-phosphate
conversion direction: LEFT_TO_RIGHT

Reaction1065
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000774 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001355 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001007 Cytoplasm/Stoichiometry/1.0
right: 5'-Phosphoribosyl-N-formylglycinamide
right: Tetrahydrofolic acid
spontaneous: false
left: 10-Formyltetrahydrofolate
left: Glycineamideribotide
name: 10-Formyltetrahydrofolate + Glycineamideribotide → 5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolic acid
conversion direction: LEFT_TO_RIGHT

2.4.2.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000190 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001080 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000086 Cytoplasm/Stoichiometry/1.0
right: Phosphoribosyl pyrophosphate
right: Guanine
spontaneous: false
EC number: 2.4.2.7
left: Guanosine monophosphate
left: Pyrophosphate
name: Guanosine monophosphate + Pyrophosphate ↔ Guanine + Phosphoribosyl pyrophosphate
conversion direction: REVERSIBLE

Adenosine monophosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Adenosine monophosphate

2.4.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001042 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000058 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000086 Cytoplasm/Stoichiometry/1.0
right: Deoxyribose 1-phosphate
right: Guanine
spontaneous: false
EC number: 2.4.2.1
left: Deoxyguanosine
left: Phosphate
name: Deoxyguanosine + Phosphate ↔ Deoxyribose 1-phosphate + Guanine
conversion direction: REVERSIBLE

ReactionCatalysis755
type: Catalysis
controller: Adenylosuccinate synthetase isozyme 2
controlled: 6.3.4.4
control type: ACTIVATION

ReactionCatalysis756
type: Catalysis
controller: AMP deaminase 1
controlled: 3.5.4.6
control type: ACTIVATION

6.3.5.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001080 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001196 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: Guanosine monophosphate
right: Pyrophosphate
spontaneous: false
EC number: 6.3.5.2
left: Adenosine triphosphate
left: Ammonia
left: Xanthylic acid
name: Adenosine triphosphate + Ammonia + Xanthylic acid → Adenosine monophosphate + Guanosine monophosphate + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 73-24-5
type: UnificationXref
id: 73-24-5
db: CAS

1.7.1.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000114 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001080 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
right: Guanosine monophosphate
right: NADPH
spontaneous: false
EC number: 1.7.1.7
left: Inosinic acid
left: Ammonia
left: NADP
name: Ammonia + Inosinic acid + NADP ↔ Guanosine monophosphate + NADPH
conversion direction: REVERSIBLE

ReactionCatalysis754
type: Catalysis
controller: Purine nucleoside phosphorylase
controlled: 2.4.2.1
control type: ACTIVATION

cAMP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: cAMP

Guanosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine diphosphate

Adenine phosphoribosyltransferase
type: ProteinReference
xref: Reference/UniProt P07741
organism: Homo sapiens

Reference/PubChem-compound 166760
type: UnificationXref
id: 166760
db: PubChem-compound

Reference/KEGG Compound C04751
type: UnificationXref
id: C04751
db: KEGG Compound

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/CAS 146-80-5
type: UnificationXref
id: 146-80-5
db: CAS

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Inosine triphosphate pyrophosphatase
type: ProteinReference
xref: Reference/UniProt Q9BY32
organism: Homo sapiens

Peroxisome
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005777

3.6.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000121 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001846 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
right: IDP
right: Phosphate
spontaneous: false
EC number: 3.6.1.5
left: Water
left: Inosine triphosphate
name: Inosine triphosphate + Water → IDP + Phosphate
conversion direction: LEFT_TO_RIGHT

2.4.2.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001168 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000190 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001801 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
right: 5-Aminoimidazole-4-carboxamide
right: Phosphoribosyl pyrophosphate
spontaneous: false
EC number: 2.4.2.7
left: AICAR
left: Pyrophosphate
name: AICAR + Pyrophosphate ↔ 5-Aminoimidazole-4-carboxamide + Phosphoribosyl pyrophosphate
conversion direction: REVERSIBLE

3.6.1.19
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000121 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000114 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
right: Inosinic acid
right: Pyrophosphate
spontaneous: false
EC number: 3.6.1.19
left: Water
left: Inosine triphosphate
name: Inosine triphosphate + Water → Inosinic acid + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000058
type: ChemicalStructure
structure format: SMILES

2.7.4.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000121 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001846 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Inosine triphosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.4.6
left: IDP
left: Adenosine triphosphate
name: Adenosine triphosphate + IDP ↔ Adenosine diphosphate + Inosine triphosphate
conversion direction: REVERSIBLE

ChemicalStructure/PW C001146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reaction1093
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001080 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007218 Cytoplasm/Stoichiometry/1.0
right: Guanosine monophosphate
spontaneous: false
left: Water
left: Guanosine 2',3'-cyclic phosphate
name: Guanosine 2',3'-cyclic phosphate + Water → Guanosine monophosphate
conversion direction: LEFT_TO_RIGHT

3.6.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001846 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000114 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
right: Inosinic acid
right: Phosphate
spontaneous: false
EC number: 3.6.1.5
left: IDP
left: Water
name: IDP + Water → Inosinic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Adenosine diphosphate

Reference/BioCyc AICAR
type: UnificationXref
id: AICAR
db: BioCyc

Reference/HMDB HMDB0001340
type: UnificationXref
id: HMDB0001340
db: HMDB

Phosphoribosylformylglycineamidine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 18413
xref: Reference/BioCyc 5-PHOSPHORIBOSYL-N-FORMYLGLYCINEAMIDINE
xref: Reference/HMDB HMDB0000999
xref: Reference/CAS 37721-04-3
xref: Reference/PubChem-compound 440417
xref: Reference/KEGG Compound C04640
xref: Reference/ChemSpider 7830994
chemical formula: C8H16N3O8P
molecular weight: 313.0675
structure: ChemicalStructure/PW C000791

2'-Deoxyguanosine 5'-monophosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: 2'-Deoxyguanosine 5'-monophosphate

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

Compound/PW C000914 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate ribose
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000050
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/UniProt Q9Y2T3
type: UnificationXref
id: Q9Y2T3
db: UniProt

Compound/PW C001801 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Aminoimidazole-4-carboxamide
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Peroxisome
entity reference: NADH

2.7.4.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001177 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001161 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Deoxyadenosine triphosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.4.6
left: Adenosine triphosphate
left: dADP
name: Adenosine triphosphate + dADP ↔ Adenosine diphosphate + Deoxyadenosine triphosphate
conversion direction: REVERSIBLE

4.6.1.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007218 Cytoplasm/Stoichiometry/1.0
right: Guanosine 2',3'-cyclic phosphate
right: Pyrophosphate
spontaneous: false
EC number: 4.6.1.2
left: Guanosine triphosphate
name: Guanosine triphosphate → Guanosine 2',3'-cyclic phosphate + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reaction1090
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000724 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001161 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Adenosine diphosphate
right: dADP
spontaneous: false
left: Deoxyadenosine monophosphate
left: Adenosine triphosphate
name: Adenosine triphosphate + Deoxyadenosine monophosphate ↔ Adenosine diphosphate + dADP
conversion direction: REVERSIBLE

Compound/PW C000087 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine
stoichiometric coefficient: 1.0

Reference/ChemSpider 768
type: UnificationXref
id: 768
db: ChemSpider

Reference/ChemSpider 8265
type: UnificationXref
id: 8265
db: ChemSpider

1.17.4.1
type: BiochemicalReaction
participant stoichiometry: Protein/5803 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001161 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Thioredoxin
spontaneous: false
EC number: 1.17.4.1
left: dADP
left: Thioredoxin
left: Water
name: Thioredoxin Disulfide + Water + dADP ↔ Adenosine diphosphate + Thioredoxin
conversion direction: REVERSIBLE

Reference/BioCyc ADENOSINE DIPHOSPHATE RIBOSE
type: UnificationXref
id: ADENOSINE_DIPHOSPHATE_RIBOSE
db: BioCyc

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Reference/CAS 73-40-5
type: UnificationXref
id: 73-40-5
db: CAS

Reference/KEGG Compound C01261
type: UnificationXref
id: C01261
db: KEGG Compound

ChemicalStructure/PW C000068
type: ChemicalStructure
structure format: SMILES

2.4.2.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000190 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000024 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Phosphoribosyl pyrophosphate
right: Adenine
spontaneous: false
EC number: 2.4.2.7
left: Adenosine monophosphate
left: Pyrophosphate
name: Adenosine monophosphate + Pyrophosphate ↔ Adenine + Phosphoribosyl pyrophosphate
conversion direction: REVERSIBLE

Guanine deaminase
type: Complex
component stoichiometry: Protein/654 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Guanine deaminase

Reference/ChemSpider 12079
type: UnificationXref
id: 12079
db: ChemSpider

Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/UniProt P50583
type: UnificationXref
id: P50583
db: UniProt

Reference/HMDB HMDB0001351
type: UnificationXref
id: HMDB0001351
db: HMDB

Compound/PW C001144 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

dGDP
type: SmallMoleculeReference
xref: Reference/BioCyc DGDP
xref: Reference/ChEBI CHEBI 28862
xref: Reference/ChemSpider 388359
xref: Reference/HMDB HMDB0000960
xref: Reference/PubChem-compound 439220
xref: Reference/CAS 3493-09-2
xref: Reference/KEGG Compound C00361
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C000767

Reference/ChEBI CHEBI 28181
type: UnificationXref
id: CHEBI:28181
db: ChEBI

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/UniProt Q06203
type: UnificationXref
id: Q06203
db: UniProt

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

Cytosolic purine 5'-nucleotidase
type: Complex
component stoichiometry: Protein/2368 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Cytosolic purine 5'-nucleotidase

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000034
type: UnificationXref
id: HMDB0000034
db: HMDB

ChemicalStructure/PW C002699
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001128
type: UnificationXref
id: HMDB0001128
db: HMDB

Reference/ChEBI CHEBI 16192
type: UnificationXref
id: CHEBI:16192
db: ChEBI

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

ChemicalStructure/PW C000034
type: ChemicalStructure
structure format: SMILES

Hypoxanthine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hypoxanthine

Compound/PW C001104 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 13135
type: UnificationXref
id: 13135
db: ChemSpider

ADP-sugar pyrophosphatase
type: Complex
component stoichiometry: Protein/594 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: ADP-sugar pyrophosphatase

10-Formyltetrahydrofolate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000972
xref: Reference/PubChem-compound 122347
xref: Reference/ChemSpider 109092
xref: Reference/ChEBI CHEBI 15637
xref: Reference/CAS 2800-34-2
xref: Reference/BioCyc 10-FORMYL-THF
xref: Reference/KEGG Compound C00234
chemical formula: C20H23N7O7
molecular weight: 473.1659
structure: ChemicalStructure/PW C000774

Reference/ChEBI CHEBI 17053
type: UnificationXref
id: CHEBI:17053
db: ChEBI

Reference/CAS 56-40-6
type: UnificationXref
id: 56-40-6
db: CAS

Reference/CAS 2800-34-2
type: UnificationXref
id: 2800-34-2
db: CAS

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: Reference/UniProt P00492
organism: Homo sapiens

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Reference/HMDB HMDB0000289
type: UnificationXref
id: HMDB0000289
db: HMDB

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 18381
type: UnificationXref
id: CHEBI:18381
db: ChEBI

Compound/PW C000058 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyguanosine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000280
type: UnificationXref
id: HMDB0000280
db: HMDB

Ammonia
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Ammonia

Cytosolic purine 5'-nucleotidase
type: Protein
cellular location: Cytoplasm
entity reference: Cytosolic purine 5'-nucleotidase

Inosine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Inosine

Compound/PW C001161 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: dADP
stoichiometric coefficient: 1.0

Reference/ChemSpider 559208
type: UnificationXref
id: 559208
db: ChemSpider

Deoxyinosine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Deoxyinosine

Adenosine deaminase
type: ProteinReference
xref: Reference/UniProt P00813
organism: Homo sapiens

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

Adenylate cyclase type 2
type: ProteinReference
xref: Reference/UniProt Q08462
organism: Homo sapiens

AMP deaminase 1
type: ProteinReference
xref: Reference/UniProt P23109
organism: Homo sapiens

Reference/BioCyc DADP
type: UnificationXref
id: DADP
db: BioCyc

Reference/HMDB HMDB0000299
type: UnificationXref
id: HMDB0000299
db: HMDB

Reference/ChemSpider 730
type: UnificationXref
id: 730
db: ChemSpider

Reference/CAS 4130-19-2
type: UnificationXref
id: 4130-19-2
db: CAS

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Reference/HMDB HMDB0000292
type: UnificationXref
id: HMDB0000292
db: HMDB

Reference/HMDB HMDB0000050
type: UnificationXref
id: HMDB0000050
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/ChEBI CHEBI 15919
type: UnificationXref
id: CHEBI:15919
db: ChEBI

Purine nucleoside phosphorylase
type: Protein
cellular location: Cytoplasm
entity reference: Purine nucleoside phosphorylase

Inosinic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 8264
xref: Reference/ChEBI CHEBI 17202
xref: Reference/CAS 131-99-7
xref: Reference/PubChem-compound 8582
xref: Reference/BioCyc IMP
xref: Reference/KEGG Compound C00130
xref: Reference/HMDB HMDB0000175
chemical formula: C10H13N4O8P
molecular weight: 348.0471
structure: ChemicalStructure/PW C000114

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

Phosphoribosyl formamidocarboxamide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphoribosyl formamidocarboxamide

Guanylate kinase
type: ProteinReference
xref: Reference/UniProt Q16774
organism: Homo sapiens

Reference/BioCyc PHOSPHORIBOSYL-FORMAMIDO-CARBOXAMIDE
type: UnificationXref
id: PHOSPHORIBOSYL-FORMAMIDO-CARBOXAMIDE
db: BioCyc

ChemicalStructure/PW C001196
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0003335
type: UnificationXref
id: HMDB0003335
db: HMDB

Reference/BioCyc RIBOSE-5P
type: UnificationXref
id: RIBOSE-5P
db: BioCyc

ChemicalStructure/PW C001191
type: ChemicalStructure
structure format: SMILES

L-Aspartic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44367445
xref: Reference/ChemSpider 5745
xref: Reference/ChEBI CHEBI 17053
xref: Reference/HMDB HMDB0000191
xref: Reference/CAS 56-84-8
xref: Reference/KEGG Compound C00049
xref: Reference/BioCyc L-ASPARTATE
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C000123

Reference/PubChem-compound 439905
type: UnificationXref
id: 439905
db: PubChem-compound

Bifunctional purine biosynthesis protein PURH
type: Protein
cellular location: Cytoplasm
entity reference: Bifunctional purine biosynthesis protein PURH

Inosine triphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000189
xref: Reference/KEGG Compound C00081
xref: Reference/CAS 132-06-9
xref: Reference/ChEBI CHEBI 16039
xref: Reference/BioCyc ITP
xref: Reference/PubChem-compound 8583
xref: Reference/ChemSpider 8265
chemical formula: C10H15N4O14P3
molecular weight: 507.97977
structure: ChemicalStructure/PW C000121

Reference/HMDB HMDB0001397
type: UnificationXref
id: HMDB0001397
db: HMDB

Reference/BioCyc PHOSPHORIBOSYL-CARBOXY-AMINOIMIDAZOLE
type: UnificationXref
id: PHOSPHORIBOSYL-CARBOXY-AMINOIMIDAZOLE
db: BioCyc

Inosinic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Inosinic acid

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Compound/PW C001783 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

GMP reductase 1
type: ProteinReference
xref: Reference/UniProt P36959
organism: Homo sapiens

Reference/ChemSpider 144983
type: UnificationXref
id: 144983
db: ChemSpider

Inosine-5'-monophosphate dehydrogenase 1
type: Protein
cellular location: Cytoplasm
entity reference: Inosine-5'-monophosphate dehydrogenase 1

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Adenosine diphosphate ribose
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate ribose

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C001168
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000078
type: ChemicalStructure
structure format: SMILES
structure data: NCC(O)=O

Reference/HMDB HMDB0000071
type: UnificationXref
id: HMDB0000071
db: HMDB

Reference/ChemSpider 54923
type: UnificationXref
id: 54923
db: ChemSpider

Reference/ChemSpider 388939
type: UnificationXref
id: 388939
db: ChemSpider

ChemicalStructure/PW C001161
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Reference/BioCyc DGMP
type: UnificationXref
id: DGMP
db: BioCyc

Reference/CAS 56-84-8
type: UnificationXref
id: 56-84-8
db: CAS

Reference/ChemSpider 163230
type: UnificationXref
id: 163230
db: ChemSpider

Guanine deaminase
type: ProteinReference
xref: Reference/UniProt Q9Y2T3
organism: Homo sapiens

Reference/ChemSpider 744
type: UnificationXref
id: 744
db: ChemSpider

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

ChemicalStructure/PW C001177
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000087
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001178
type: UnificationXref
id: HMDB0001178
db: HMDB

ChemicalStructure/PW C000086
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC(=O)C2=C(N1)N=CN2

Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

Hypoxanthine
type: SmallMoleculeReference
xref: Reference/CAS 68-94-0
xref: Reference/HMDB HMDB0000157
xref: Reference/ChEBI CHEBI 17368
xref: Reference/PubChem-compound 790
xref: Reference/KEGG Compound C00262
xref: Reference/BioCyc HYPOXANTHINE
xref: Reference/ChemSpider 768
chemical formula: C5H4N4O
molecular weight: 136.03851
structure: ChemicalStructure/PW C000102

Reference/CAS 902-04-5
type: UnificationXref
id: 902-04-5
db: CAS

Reference/HMDB HMDB0000085
type: UnificationXref
id: HMDB0000085
db: HMDB

Reference/HMDB HMDB0002022
type: UnificationXref
id: HMDB0002022
db: HMDB

Reference/BioCyc DGTP
type: UnificationXref
id: DGTP
db: BioCyc

ReactionCatalysis17
type: Catalysis
controller: Adenylosuccinate lyase
controlled: 4.3.2.2
control type: ACTIVATION

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
type: Complex
component stoichiometry: Protein/571 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Reference/PubChem-compound 65110
type: UnificationXref
id: 65110
db: PubChem-compound

Reference/BioCyc RIBOSE-1P
type: UnificationXref
id: RIBOSE-1P
db: BioCyc

Reference/CAS 653-63-4
type: UnificationXref
id: 653-63-4
db: CAS

Reference/CAS 3031-94-5
type: UnificationXref
id: 3031-94-5
db: CAS

Pentose Phosphate Pathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway132
pathway component: SubPathwayInteraction132
xref: Reference/PathWhiz PW000055
xref: Reference/SMPDB SMP0000031
name: SubPathway

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Compound/PW C001080 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine monophosphate
stoichiometric coefficient: 1.0

2.7.4.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000767 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001112 Cytoplasm/Stoichiometry/1.0
right: dGTP
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.4.6
left: Adenosine triphosphate
left: dGDP
name: Adenosine triphosphate + dGDP → Adenosine diphosphate + dGTP
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc P-RIBOSYL-4-SUCCCARB-AMINOIMIDAZOLE
type: UnificationXref
id: P-RIBOSYL-4-SUCCCARB-AMINOIMIDAZOLE
db: BioCyc

Reference/PubChem-compound 65103
type: UnificationXref
id: 65103
db: PubChem-compound

2.7.4.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000986 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000936 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Adenosine diphosphate
right: Guanosine triphosphate
spontaneous: false
EC number: 2.7.4.6
left: Adenosine triphosphate
left: Guanosine diphosphate
name: Adenosine triphosphate + Guanosine diphosphate ↔ Adenosine diphosphate + Guanosine triphosphate
conversion direction: REVERSIBLE

Deoxyguanosine kinase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q16854
organism: Homo sapiens

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

5'-Phosphoribosyl-N-formylglycinamide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001308
xref: Reference/CAS 349-34-8
xref: Reference/PubChem-compound 130805
xref: Reference/ChemSpider 115687
xref: Reference/KEGG Compound C04376
xref: Reference/BioCyc 5-P-RIBOSYL-N-FORMYLGLYCINEAMIDE
chemical formula: C8H15N2O9P
molecular weight: 314.0515
structure: ChemicalStructure/PW C001007

Reference/HMDB HMDB0001508
type: UnificationXref
id: HMDB0001508
db: HMDB

Ectonucleoside triphosphate diphosphohydrolase 8
type: ProteinReference
xref: Reference/UniProt Q5MY95
organism: Homo sapiens

Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

Adenine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenine

Compound/PW C002699 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
stoichiometric coefficient: 1.0

Reference/BioCyc ITP
type: UnificationXref
id: ITP
db: BioCyc

Reference/CAS 131-99-7
type: UnificationXref
id: 131-99-7
db: CAS

ChemicalStructure/PW C000102
type: ChemicalStructure
structure format: SMILES
structure data: OC1=NC=NC2=C1NC=N2

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Glycine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glycine

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Compound/PW C000041 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Inosine
type: SmallMoleculeReference
xref: Reference/CAS 58-63-9
xref: Reference/PubChem-compound 6021
xref: Reference/KEGG Compound C00294
xref: Reference/BioCyc INOSINE
xref: Reference/ChemSpider 5799
xref: Reference/ChEBI CHEBI 17596
xref: Reference/HMDB HMDB0000195
chemical formula: C10H12N4O5
molecular weight: 268.08078
structure: ChemicalStructure/PW C000127

Reference/HMDB HMDB0001517
type: UnificationXref
id: HMDB0001517
db: HMDB

3.5.4.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000050 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000068 Cytoplasm/Stoichiometry/1.0
right: Deoxyinosine
right: Ammonia
spontaneous: false
EC number: 3.5.4.4
left: Deoxyadenosine
left: Water
name: Deoxyadenosine + Water ↔ Ammonia + Deoxyinosine
conversion direction: REVERSIBLE

Protein/571 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
stoichiometric coefficient: 2.0

3.5.4.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000127 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000034 Cytoplasm/Stoichiometry/1.0
right: Inosine
right: Ammonia
spontaneous: false
EC number: 3.5.4.4
left: Water
left: Adenosine
name: Adenosine + Water → Ammonia + Inosine
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C04376
type: UnificationXref
id: C04376
db: KEGG Compound

ChemicalStructure/PW C000791
type: ChemicalStructure
structure format: SMILES

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Compound/PW C000114 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Inosinic acid
stoichiometric coefficient: 1.0

Tetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 20506
xref: Reference/ChemSpider 18714427
xref: Reference/HMDB HMDB0001846
xref: Reference/PubChem-compound 13781857
xref: Reference/BioCyc THF
xref: Reference/CAS 135-16-0
xref: Reference/KEGG Compound C00101
chemical formula: C19H23N7O6
molecular weight: 445.171
structure: ChemicalStructure/PW C001221

Protein/649 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: GMP reductase 1
stoichiometric coefficient: 4.0

Ectonucleoside triphosphate diphosphohydrolase 8
type: Protein
cellular location: Cell Membrane
entity reference: Ectonucleoside triphosphate diphosphohydrolase 8

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Guanosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine diphosphate

Deoxyguanosine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Deoxyguanosine

Guanosine diphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Guanosine diphosphate

ReactionCatalysis44
type: Catalysis
controller: Amidophosphoribosyltransferase
controlled: 2.4.2.14
control type: ACTIVATION

Reference/HMDB HMDB0001532
type: UnificationXref
id: HMDB0001532
db: HMDB

Adenosine triphosphate
type: SmallMolecule
cellular location: Peroxisome
entity reference: Adenosine triphosphate

Compound/PW C000024 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenine
stoichiometric coefficient: 1.0

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/BioCyc THF
type: UnificationXref
id: THF
db: BioCyc

Reference/ChEBI CHEBI 15883
type: UnificationXref
id: CHEBI:15883
db: ChEBI

Reference/ChemSpider 145893
type: UnificationXref
id: 145893
db: ChemSpider

Reference/BioCyc GLY
type: UnificationXref
id: GLY
db: BioCyc

Reference/UniProt P10599
type: UnificationXref
id: P10599
db: UniProt

Protein/2369 Cytoplasm/Stoichiometry/3.0
type: Stoichiometry
physical entity: Purine nucleoside phosphorylase
stoichiometric coefficient: 3.0

Guanosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine triphosphate

3.1.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001196 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000203 Cytoplasm/Stoichiometry/1.0
right: Xanthosine
right: Phosphate
spontaneous: false
EC number: 3.1.3.5
left: Water
left: Xanthylic acid
name: Water + Xanthylic acid → Phosphate + Xanthosine
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000127
type: ChemicalStructure
structure format: SMILES

3.1.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000724 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000068 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
right: Deoxyadenosine
right: Phosphoric acid
spontaneous: false
EC number: 3.1.3.5
left: Deoxyadenosine monophosphate
left: Water
name: Deoxyadenosine monophosphate + Water ↔ Deoxyadenosine + Phosphoric acid
conversion direction: REVERSIBLE

ChemicalStructure/PW C001221
type: ChemicalStructure
structure format: SMILES

Deoxyribose 1-phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439287
xref: Reference/KEGG Compound C00672
xref: Reference/CAS 17210-42-3
xref: Reference/BioCyc DEOXY-RIBOSE-1P
xref: Reference/HMDB HMDB0001351
xref: Reference/ChemSpider 388420
xref: Reference/ChEBI CHEBI 28542
chemical formula: C5H11O7P
molecular weight: 214.02425
structure: ChemicalStructure/PW C001042

Guanosine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Guanosine

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

Phosphoribosyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00119
xref: Reference/ChemSpider 7062
xref: Reference/CAS 7540-64-9
xref: Reference/HMDB HMDB0000280
xref: Reference/PubChem-compound 7339
xref: Reference/BioCyc PRPP
xref: Reference/ChEBI CHEBI 17111
chemical formula: C5H13O14P3
molecular weight: 389.9518
structure: ChemicalStructure/PW C000190

Reference/CAS 86-04-4
type: UnificationXref
id: 86-04-4
db: CAS

Reference/BioCyc GMP
type: UnificationXref
id: GMP
db: BioCyc

Reference/BioCyc GUANOSINE
type: UnificationXref
id: GUANOSINE
db: BioCyc

Reference/UniProt P22102
type: UnificationXref
id: P22102
db: UniProt

Reference/HMDB HMDB0001548
type: UnificationXref
id: HMDB0001548
db: HMDB

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 15637
type: UnificationXref
id: CHEBI:15637
db: ChEBI

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Xanthine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17712
xref: Reference/ChemSpider 1151
xref: Reference/KEGG Compound C00385
xref: Reference/HMDB HMDB0000292
xref: Reference/CAS 69-89-6
xref: Reference/BioCyc XANTHINE
xref: Reference/PubChem-compound 1188
chemical formula: C5H4N4O2
molecular weight: 152.03343
structure: ChemicalStructure/PW C000198

Uric acid
type: SmallMoleculeReference
xref: Reference/BioCyc URATE
xref: Reference/HMDB HMDB0000289
xref: Reference/ChEBI CHEBI 17775
xref: Reference/CAS 69-93-2
xref: Reference/PubChem-compound 1175
xref: Reference/KEGG Compound C00366
xref: Reference/ChemSpider 1142
chemical formula: C5H4N4O3
molecular weight: 168.02834
structure: ChemicalStructure/PW C000195

Reference/ChEBI CHEBI 15652
type: UnificationXref
id: CHEBI:15652
db: ChEBI

Adenylsuccinic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenylsuccinic acid

Reference/HMDB HMDB0001308
type: UnificationXref
id: HMDB0001308
db: HMDB

ATPase family AAA domain-containing protein 1
type: Protein
cellular location: Peroxisome
entity reference: ATPase family AAA domain-containing protein 1

Reference/CAS 19046-78-7
type: UnificationXref
id: 19046-78-7
db: CAS

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/PubChem-compound 5257127
type: UnificationXref
id: 5257127
db: PubChem-compound

Reference/HMDB HMDB0001554
type: UnificationXref
id: HMDB0001554
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Ectonucleoside triphosphate diphosphohydrolase 8
type: Protein
cellular location: Cytoplasm
entity reference: Ectonucleoside triphosphate diphosphohydrolase 8

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/UniProt P00568
type: UnificationXref
id: P00568
db: UniProt

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/PubChem-compound 60961
type: UnificationXref
id: 60961
db: PubChem-compound

Compound/PW C001146 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribose 1-phosphate
stoichiometric coefficient: 1.0

Reference/UniProt O15067
type: UnificationXref
id: O15067
db: UniProt

Compound/PW C001034 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/ChemSpider 8264
type: UnificationXref
id: 8264
db: ChemSpider

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

ChemicalStructure/PW C000114
type: ChemicalStructure
structure format: SMILES

Trifunctional purine biosynthetic protein adenosine-3
type: Protein
cellular location: Cytosol
entity reference: Trifunctional purine biosynthetic protein adenosine-3

Reference/KEGG Compound C03090
type: UnificationXref
id: C03090
db: KEGG Compound

Reference/ChEBI CHEBI 16708
type: UnificationXref
id: CHEBI:16708
db: ChEBI

3.1.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000058 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000822 Cytoplasm/Stoichiometry/1.0
right: Deoxyguanosine
right: Phosphate
spontaneous: false
EC number: 3.1.3.5
left: 2'-Deoxyguanosine 5'-monophosphate
left: Water
name: 2'-Deoxyguanosine 5'-monophosphate + Water ↔ Deoxyguanosine + Phosphate
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 16960
type: UnificationXref
id: CHEBI:16960
db: ChEBI

Protein/837 Cytoplasm/Stoichiometry/8.0
type: Stoichiometry
physical entity: Multifunctional protein ADE2
stoichiometric coefficient: 8.0

3.1.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001080 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000087 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
right: Guanosine
right: Phosphoric acid
spontaneous: false
EC number: 3.1.3.5
left: Guanosine monophosphate
left: Water
name: Guanosine monophosphate + Water → Guanosine + Phosphoric acid
conversion direction: LEFT_TO_RIGHT

3.1.3.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000114 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000127 Cytoplasm/Stoichiometry/1.0
right: Inosine
right: Phosphate
spontaneous: false
EC number: 3.1.3.5
left: Inosinic acid
left: Water
name: Inosinic acid + Water → Inosine + Phosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000121
type: ChemicalStructure
structure format: SMILES

Diguanosine tetraphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15883
xref: Reference/CAS 4130-19-2
xref: Reference/KEGG Compound C01261
xref: Reference/PubChem-compound 165186
xref: Reference/ChemSpider 144813
xref: Reference/BioCyc CPD-609
xref: Reference/HMDB HMDB0001340
chemical formula: C20H28N10O21P4
molecular weight: 868.0381
structure: ChemicalStructure/PW C001033

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

ChemicalStructure/PW C000123
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(O)=O)C(O)=O

ReactionCatalysis80
type: Catalysis
controller: Adenylate cyclase type 2
controlled: 4.6.1.1
control type: ACTIVATION

Reference/ChEBI CHEBI 17808
type: UnificationXref
id: CHEBI:17808
db: ChEBI

Reference/BioCyc 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL
type: UnificationXref
id: 5-PHOSPHORIBOSYL-5-AMINOIMIDAZOL
db: BioCyc

Reference/ChemSpider 58620
type: UnificationXref
id: 58620
db: ChemSpider

Compound/PW C000102 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hypoxanthine
stoichiometric coefficient: 1.0

Protein/826 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Inosine-5'-monophosphate dehydrogenase 1
stoichiometric coefficient: 4.0

ReactionCatalysis790
type: Catalysis
controller: Adenine phosphoribosyltransferase
controlled: 2.4.2.7
control type: ACTIVATION

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Reference/PubChem-compound 161500
type: UnificationXref
id: 161500
db: PubChem-compound

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Deoxyguanosine kinase
type: Complex
component stoichiometry: Protein/713 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Deoxyguanosine kinase, mitochondrial

ChemicalStructure/PW C000724
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc IMP
type: UnificationXref
id: IMP
db: BioCyc

Guanosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 85-32-5
xref: Reference/ChEBI CHEBI 17345
xref: Reference/BioCyc GMP
xref: Reference/PubChem-compound 6804
xref: Reference/KEGG Compound C00144
xref: Reference/ChemSpider 6545
xref: Reference/HMDB HMDB0001397
chemical formula: C10H14N5O8P
molecular weight: 363.058
structure: ChemicalStructure/PW C001080

3.6.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Guanosine diphosphate
right: Phosphate
spontaneous: false
EC number: 3.6.1.5
left: Guanosine triphosphate
left: Water
name: Guanosine triphosphate + Water → Guanosine diphosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

Purine nucleoside phosphorylase
type: Complex
component stoichiometry: Protein/2369 Cytoplasm/Stoichiometry/3.0
cellular location: Cytoplasm
component: Purine nucleoside phosphorylase

Protein/176 Peroxisome/Stoichiometry/2.0
type: Stoichiometry
physical entity: Xanthine dehydrogenase/oxidase
stoichiometric coefficient: 2.0

ReactionCatalysis788
type: Catalysis
controller: Nucleoside diphosphate kinase 6
controlled: 2.7.4.6
control type: ACTIVATION

ReactionCatalysis789
type: Catalysis
controller: Ectonucleoside triphosphate diphosphohydrolase 8
controlled: 3.6.1.5
control type: ACTIVATION

Xanthine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Xanthine

2.4.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000198 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000203 Cytoplasm/Stoichiometry/1.0
right: Ribose 1-phosphate
right: Xanthine
spontaneous: false
EC number: 2.4.2.1
left: Xanthosine
left: Phosphate
name: Phosphate + Xanthosine ↔ Ribose 1-phosphate + Xanthine
conversion direction: REVERSIBLE

ReactionCatalysis786
type: Catalysis
controller: Ectonucleoside triphosphate diphosphohydrolase 8
controlled: 3.6.1.5
control type: ACTIVATION

ReactionCatalysis787
type: Catalysis
controller: Inosine triphosphate pyrophosphatase
controlled: 3.6.1.19
control type: ACTIVATION

ReactionCatalysis784
type: Catalysis
controller: Guanylate cyclase
controlled: 4.6.1.2
control type: ACTIVATION

Reference/ChEBI CHEBI 16300
type: UnificationXref
id: CHEBI:16300
db: ChEBI

ReactionCatalysis785
type: Catalysis
controller: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
controlled: Reaction1093
control type: ACTIVATION

ReactionCatalysis782
type: Catalysis
controller: Cytosolic purine 5'-nucleotidase
controlled: 3.1.3.5
control type: ACTIVATION

Guanylate kinase
type: Protein
cellular location: Cytoplasm
entity reference: Guanylate kinase

ReactionCatalysis783
type: Catalysis
controller: Nucleoside diphosphate kinase 6
controlled: 2.7.4.6
control type: ACTIVATION

Reference/ChemSpider 5799
type: UnificationXref
id: 5799
db: ChemSpider

ReactionCatalysis780
type: Catalysis
controller: Ribonucleoside-diphosphate reductase 1
controlled: 1.17.4.1
control type: ACTIVATION

ReactionCatalysis781
type: Catalysis
controller: Adenylate kinase isoenzyme 1
controlled: Reaction1090
control type: ACTIVATION

Hypoxanthine-guanine phosphoribosyltransferase
type: Protein
cellular location: Cytoplasm
entity reference: Hypoxanthine-guanine phosphoribosyltransferase

Adenosine diphosphate
type: SmallMolecule
cellular location: Peroxisome
entity reference: Adenosine diphosphate

Reference/PubChem-compound 440417
type: UnificationXref
id: 440417
db: PubChem-compound

Reference/ChEBI CHEBI 28997
type: UnificationXref
id: CHEBI:28997
db: ChEBI

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Protein/1001 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanylate cyclase soluble subunit beta-1
stoichiometric coefficient: 1.0

Protein/325 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Amidophosphoribosyltransferase
stoichiometric coefficient: 4.0

4.3.2.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001168 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000637 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Cytoplasm/Stoichiometry/1.0
right: Fumaric acid
right: AICAR
spontaneous: false
EC number: 4.3.2.2
left: SAICAR
name: SAICAR ↔ AICAR + Fumaric acid
conversion direction: REVERSIBLE

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reaction487
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002699 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000123 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000637 Cytoplasm/Stoichiometry/1.0
right: SAICAR
right: Adenosine diphosphate
right: Phosphoric acid
spontaneous: false
left: L-Aspartic acid
left: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
left: Adenosine triphosphate
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + Adenosine triphosphate + L-Aspartic acid ↔ Adenosine diphosphate + Phosphoric acid + SAICAR
conversion direction: REVERSIBLE

6.3.5.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000791 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001007 Cytoplasm/Stoichiometry/1.0
right: L-Glutamic acid
right: Adenosine diphosphate
right: Phosphoric acid
right: Phosphoribosylformylglycineamidine
spontaneous: false
EC number: 6.3.5.3
left: Water
left: Adenosine triphosphate
left: 5'-Phosphoribosyl-N-formylglycinamide
left: L-Glutamine
name: 5'-Phosphoribosyl-N-formylglycinamide + Adenosine triphosphate + L-Glutamine + Water → Adenosine diphosphate + L-Glutamic acid + Phosphoribosylformylglycineamidine + Phosphoric acid
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis777
type: Catalysis
controller: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
controlled: 3.1.4.53
control type: ACTIVATION

Reaction486
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002699 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000955 Cytoplasm/Stoichiometry/1.0
right: 5-Aminoimidazole ribonucleotide
right: Carbon dioxide
spontaneous: false
left: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate ↔ 5-Aminoimidazole ribonucleotide + Carbon dioxide
conversion direction: REVERSIBLE

Compound/PW C001441 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Reaction483
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001355 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000882 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphate
right: Glycineamideribotide
spontaneous: false
left: Glycine
left: 5-Phosphoribosylamine
left: Adenosine triphosphate
name: 5-Phosphoribosylamine + Adenosine triphosphate + Glycine → Adenosine diphosphate + Glycineamideribotide + Phosphate
conversion direction: LEFT_TO_RIGHT

NADPH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADPH

ReactionCatalysis775
type: Catalysis
controller: ATPase family AAA domain-containing protein 1
controlled: 3.6.1.3
control type: ACTIVATION

Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

Reaction484
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000791 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000955 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Adenosine diphosphate
right: 5-Aminoimidazole ribonucleotide
spontaneous: false
left: Adenosine triphosphate
left: Phosphoribosylformylglycineamidine
name: Adenosine triphosphate + Phosphoribosylformylglycineamidine → 5-Aminoimidazole ribonucleotide + Adenosine diphosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 14075-00-4
type: UnificationXref
id: 14075-00-4
db: CAS

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Protein/654 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Guanine deaminase
stoichiometric coefficient: 2.0

Phosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Phosphate

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/ChEBI CHEBI 16750
type: UnificationXref
id: CHEBI:16750
db: ChEBI

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reaction250
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000032 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Adenosine monophosphate
right: Phosphoric acid
spontaneous: false
left: Water
left: Adenosine diphosphate
name: Adenosine diphosphate + Water ↔ Adenosine monophosphate + Phosphoric acid
conversion direction: REVERSIBLE

Reaction490
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000114 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001111 Cytoplasm/Stoichiometry/1.0
right: Phosphoribosyl formamidocarboxamide
spontaneous: false
left: Inosinic acid
left: Water
name: Inosinic acid + Water ↔ Phosphoribosyl formamidocarboxamide
conversion direction: REVERSIBLE

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/CAS 360-97-4
type: UnificationXref
id: 360-97-4
db: CAS

Phosphoribosylformylglycineamidine
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoribosylformylglycineamidine

Compound/PW C001221 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrofolic acid
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000144
type: UnificationXref
id: SMP0000144
db: SMPDB

dADP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: dADP

Compound/PW C001007 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5'-Phosphoribosyl-N-formylglycinamide
stoichiometric coefficient: 1.0

Reference/BioCyc DAMP
type: UnificationXref
id: DAMP
db: BioCyc

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/CAS 349-34-8
type: UnificationXref
id: 349-34-8
db: CAS

ChemicalStructure/PW C001801
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)C1=C(N)N=CN1

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Reference/PubChem-compound 160666
type: UnificationXref
id: 160666
db: PubChem-compound

Reference/KEGG Compound C00620
type: UnificationXref
id: C00620
db: KEGG Compound

Reference/UniProt P36959
type: UnificationXref
id: P36959
db: UniProt

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

ChemicalStructure/PW C000955
type: ChemicalStructure
structure format: SMILES

Guanylate cyclase soluble subunit beta-1
type: Protein
cellular location: Cytoplasm
entity reference: Guanylate cyclase soluble subunit beta-1

Reference/ChEBI CHEBI 15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

Reference/ChemSpider 115687
type: UnificationXref
id: 115687
db: ChemSpider

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/CAS 132-06-9
type: UnificationXref
id: 132-06-9
db: CAS

Reference/ChEBI CHEBI 16335
type: UnificationXref
id: CHEBI:16335
db: ChEBI

Compound/PW C000068 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyadenosine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000767
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 130805
type: UnificationXref
id: 130805
db: PubChem-compound

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/ChemSpider 389122
type: UnificationXref
id: 389122
db: ChemSpider

Reference/PubChem-compound 439236
type: UnificationXref
id: 439236
db: PubChem-compound

ChemicalStructure/PW C000774
type: ChemicalStructure
structure format: SMILES

Nucleoside diphosphate kinase 6
type: Protein
cellular location: Cytoplasm
entity reference: Nucleoside diphosphate kinase 6

Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/BioCyc DATP
type: UnificationXref
id: DATP
db: BioCyc

Compound/PW C000791 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosylformylglycineamidine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Reference/PubChem-compound 439220
type: UnificationXref
id: 439220
db: PubChem-compound

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/KEGG Compound C06194
type: UnificationXref
id: C06194
db: KEGG Compound

Compound/PW C001034 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

3.1.4.53
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000041 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
spontaneous: false
EC number: 3.1.4.53
left: Water
left: cAMP
name: Water + cAMP → Adenosine monophosphate
conversion direction: LEFT_TO_RIGHT

Phosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Phosphate

Reference/BioCyc DEOXYINOSINE
type: UnificationXref
id: DEOXYINOSINE
db: BioCyc

Reference/KEGG Compound C00655
type: UnificationXref
id: C00655
db: KEGG Compound

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Reference/CAS 17210-42-3
type: UnificationXref
id: 17210-42-3
db: CAS

Ribose-phosphate pyrophosphokinase 3
type: Complex
component stoichiometry: Protein/537 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Ribose-phosphate pyrophosphokinase 3

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Deoxyribose 1-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Deoxyribose 1-phosphate

Reference/CAS 961-07-9
type: UnificationXref
id: 961-07-9
db: CAS

Inosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Inosine triphosphate

dGDP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: dGDP

Reference/ChEBI CHEBI 28542
type: UnificationXref
id: CHEBI:28542
db: ChEBI

Reference/ChemSpider 58613
type: UnificationXref
id: 58613
db: ChemSpider

Reference/BioCyc URATE
type: UnificationXref
id: URATE
db: BioCyc

Reference/UniProt P33402
type: UnificationXref
id: P33402
db: UniProt

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/UniProt Q16854
type: UnificationXref
id: Q16854
db: UniProt

2.4.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000087 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000086 Cytoplasm/Stoichiometry/1.0
right: Ribose 1-phosphate
right: Guanine
spontaneous: false
EC number: 2.4.2.1
left: Guanosine
left: Phosphate
name: Guanosine + Phosphate ↔ Guanine + Ribose 1-phosphate
conversion direction: REVERSIBLE

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

ChemicalStructure/PW C001846
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Reference/ChemSpider 187
type: UnificationXref
id: 187
db: ChemSpider

Reference/CAS 20762-30-5
type: UnificationXref
id: 20762-30-5
db: CAS

2.4.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000024 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000034 Cytoplasm/Stoichiometry/1.0
right: Ribose 1-phosphate
right: Adenine
spontaneous: false
EC number: 2.4.2.1
left: Adenosine
left: Phosphate
name: Adenosine + Phosphate ↔ Adenine + Ribose 1-phosphate
conversion direction: REVERSIBLE

Reference/ChemSpider 185
type: UnificationXref
id: 185
db: ChemSpider

2.7.1.113
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000058 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000822 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrion/Stoichiometry/1.0
right: Adenosine diphosphate
right: 2'-Deoxyguanosine 5'-monophosphate
spontaneous: false
EC number: 2.7.1.113
left: Adenosine triphosphate
left: Deoxyguanosine
name: Adenosine triphosphate + Deoxyguanosine ↔ 2'-Deoxyguanosine 5'-monophosphate + Adenosine diphosphate
conversion direction: REVERSIBLE

Reference/PubChem-compound 13781857
type: UnificationXref
id: 13781857
db: PubChem-compound

2.4.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000102 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000127 Cytoplasm/Stoichiometry/1.0
right: Ribose 1-phosphate
right: Hypoxanthine
spontaneous: false
EC number: 2.4.2.1
left: Inosine
left: Phosphate
name: Inosine + Phosphate ↔ Hypoxanthine + Ribose 1-phosphate
conversion direction: REVERSIBLE

Compound/PW C000791 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosylformylglycineamidine
stoichiometric coefficient: 1.0

Reference/CAS 4300-28-1
type: UnificationXref
id: 4300-28-1
db: CAS