Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Histidine--tRNA ligase, cytoplasmic
type: Complex
component stoichiometry: Protein/611 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Histidine--tRNA ligase, cytoplasmic

Reference/KEGG Compound C00439
type: UnificationXref
id: C00439
db: KEGG Compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

L-Histidine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Histidine

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

Imidazole-4-acetaldehyde
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Imidazole-4-acetaldehyde

Carnosine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Carnosine

Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Amiloride-sensitive amine oxidase [copper-containing]
type: ProteinReference
xref: Reference/UniProt P19801
organism: Homo sapiens

Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Tetrahydrofolic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Tetrahydrofolic acid

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Reference/ChEBI CHEBI 27398
type: UnificationXref
id: CHEBI:27398
db: ChEBI

Reference/ChEBI CHEBI 20506
type: UnificationXref
id: CHEBI:20506
db: ChEBI

Protein/611 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Histidine--tRNA ligase, cytoplasmic
stoichiometric coefficient: 2.0

L-Histidyl-tRNA(His)
type: Rna
cellular location: Cytoplasm
entity reference: L-Histidyl-tRNA(His)

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Histidine decarboxylase
type: Complex
component stoichiometry: Protein/828 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Histidine decarboxylase

Aldehyde dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/289 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Aldehyde dehydrogenase, mitochondrial

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/ChEBI CHEBI 18323
type: UnificationXref
id: CHEBI:18323
db: ChEBI

Reference/ChemSpider 388363
type: UnificationXref
id: 388363
db: ChemSpider

1-Methylhistamine
type: SmallMoleculeReference
xref: Reference/CAS 501-75-7
xref: Reference/PubChem-compound 3614
xref: Reference/ChemSpider 3488
xref: Reference/ChEBI CHEBI 29009
xref: Reference/HMDB HMDB0000898
xref: Reference/KEGG Compound C05127
xref: Reference/BioCyc N-METHYL-HISTAMINE
chemical formula: C6H11N3
molecular weight: 125.0953
structure: ChemicalStructure/PW C000717

Reference/UniProt Q96N76
type: UnificationXref
id: Q96N76
db: UniProt

Reference/ChemSpider 18714427
type: UnificationXref
id: 18714427
db: ChemSpider

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

ChemicalStructure/PW C002083
type: ChemicalStructure
structure format: SMILES
structure data: CN1C=NC(CC=O)=C1

Reference/ChEBI CHEBI 27384
type: UnificationXref
id: CHEBI:27384
db: ChEBI

Compound/PW C000717 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-Methylhistamine
stoichiometric coefficient: 1.0

4-Imidazolone-5-propionic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001014
xref: Reference/KEGG Compound C03680
xref: Reference/ChemSpider 125
xref: Reference/PubChem-compound 128
xref: Reference/BioCyc 4-IMIDAZOLONE-5-PROPIONATE
xref: Reference/CAS 17340-16-8
xref: Reference/ChEBI CHEBI 27384
chemical formula: C6H8N2O3
molecular weight: 156.0535
structure: ChemicalStructure/PW C000802

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Histamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Histamine

Compound/PW C002083 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methylimidazole acetaldehyde
stoichiometric coefficient: 1.0

ReactionCatalysis62987
type: Catalysis
controller: Carnosine synthase 1
controlled: Reaction72858
control type: ACTIVATION

ReactionCatalysis62986
type: Catalysis
controller: Carnosine N-methyltransferase
controlled: Reaction72857
control type: ACTIVATION

Compound/PW C000921 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Reference/ChemSpider 100482
type: UnificationXref
id: 100482
db: ChemSpider

ReactionCatalysis62988
type: Catalysis
controller: cytosolic non-specific dipeptidase
controlled: 3.4.13.18
control type: ACTIVATION

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/CAS 17340-16-8
type: UnificationXref
id: 17340-16-8
db: CAS

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/ChEBI CHEBI 28104
type: UnificationXref
id: CHEBI:28104
db: ChEBI

Carbon dioxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Carbon dioxide

Aldehyde dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P05091
organism: Homo sapiens

Formimidoyltransferase-cyclodeaminase
type: Complex
component stoichiometry: Protein/650 Cytoplasm/Stoichiometry/8.0
cellular location: Cytoplasm
component: Formimidoyltransferase-cyclodeaminase

Aldehyde dehydrogenase, dimeric NADP-preferring
type: ProteinReference
xref: Reference/UniProt P30838
organism: Homo sapiens

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: Reference/UniProt P21397
organism: Homo sapiens

Carnosine synthase 1
type: Complex
component stoichiometry: Protein/4059 Cytoplasm/Stoichiometry/4.0
cellular location: Cytoplasm
component: Carnosine synthase 1

Reference/PubChem-compound 64969
type: UnificationXref
id: 64969
db: PubChem-compound

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/PubChem-compound 6274
type: UnificationXref
id: 6274
db: PubChem-compound

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine monophosphate

Compound/PW C001992 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Imidazole-4-acetaldehyde
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/BioCyc 4-IMIDAZOLONE-5-PROPIONATE
type: UnificationXref
id: 4-IMIDAZOLONE-5-PROPIONATE
db: BioCyc

Compound/PW C000802 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Imidazolone-5-propionic acid
stoichiometric coefficient: 1.0

Carnosine synthase 1
type: ProteinReference
xref: Reference/UniProt A5YM72
organism: Homo sapiens

Reference/ChemSpider 58494
type: UnificationXref
id: 58494
db: ChemSpider

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/KEGG Compound C00101
type: UnificationXref
id: C00101
db: KEGG Compound

Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Carnosine
type: SmallMolecule
cellular location: Cytosol
entity reference: Carnosine

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Imidazoleacetic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Imidazoleacetic acid

Compound/PW C000414 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 643824
type: UnificationXref
id: 643824
db: ChemSpider

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

L-Glutamic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamic acid
name: SubPathwayInput

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Methylimidazoleacetic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002820
xref: Reference/ChEBI CHEBI 1606
xref: Reference/PubChem-compound 75810
xref: Reference/CAS 2625-49-2
xref: Reference/KEGG Compound C05828
xref: Reference/ChemSpider 68319
chemical formula: C6H8N2O2
molecular weight: 140.05858
structure: ChemicalStructure/PW C001712

ChemicalStructure/PW C000802
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC1N=CNC1=O

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

Reference/UniProt Q96NU7
type: UnificationXref
id: Q96NU7
db: UniProt

Reference/UniProt A5YM72
type: UnificationXref
id: A5YM72
db: UniProt

Reference/UniProt P50135
type: UnificationXref
id: P50135
db: UniProt

Carnosine N-methyltransferase
type: ProteinReference
xref: Reference/UniProt Q8N4J0
organism: Homo sapiens

1.4.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002083 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000717 Cytoplasm/Stoichiometry/1.0
right: Hydrogen peroxide
right: Methylimidazole acetaldehyde
right: Ammonia
spontaneous: false
EC number: 1.4.3.4
left: Oxygen
left: Water
left: 1-Methylhistamine
name: 1-Methylhistamine + Oxygen + Water → Ammonia + Hydrogen peroxide + Methylimidazole acetaldehyde
conversion direction: LEFT_TO_RIGHT

Urocanic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Urocanic acid

cytosolic non-specific dipeptidase
type: ProteinReference
xref: Reference/UniProt Q96KP4
organism: Homo sapiens

3-Methylhistidine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3-Methylhistidine

Reference/PubChem-compound 193545
type: UnificationXref
id: 193545
db: PubChem-compound

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/ChEBI CHEBI 1606
type: UnificationXref
id: CHEBI:1606
db: ChEBI

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/CAS 19639-03-3
type: UnificationXref
id: 19639-03-3
db: CAS

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Compound/PW C000693 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histamine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 7274
type: UnificationXref
id: CHEBI:7274
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/CAS 135-16-0
type: UnificationXref
id: 135-16-0
db: CAS

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

NADP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADP

Reference/UniProt Q96KN2
type: UnificationXref
id: Q96KN2
db: UniProt

RNA/24 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Histidyl-tRNA(His)
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 29009
type: UnificationXref
id: CHEBI:29009
db: ChEBI

Protein/4059 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Carnosine synthase 1
stoichiometric coefficient: 4.0

Compound/PW C001179 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Formiminotetrahydrofolic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Reference/ChemSpider 3488
type: UnificationXref
id: 3488
db: ChemSpider

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05828
type: UnificationXref
id: C05828
db: KEGG Compound

Reference/KEGG Compound C05827
type: UnificationXref
id: C05827
db: KEGG Compound

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Formimidoyltransferase-cyclodeaminase
type: Protein
cellular location: Cytoplasm
entity reference: Formimidoyltransferase-cyclodeaminase

Reference/KEGG Compound C00135
type: UnificationXref
id: C00135
db: KEGG Compound

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Oxygen
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Oxygen

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

1-Methylhistidine
type: SmallMolecule
cellular location: Cytosol
entity reference: 1-Methylhistidine

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/ChemSpider 11267158
type: UnificationXref
id: 11267158
db: ChemSpider

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

Beta-Ala-His dipeptidase
type: Protein
cellular location: Cytoplasm
entity reference: Beta-Ala-His dipeptidase

Reference/KEGG Compound C00386
type: UnificationXref
id: C00386
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/KEGG Compound C00388
type: UnificationXref
id: C00388
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/UniProt Q96KP4
type: UnificationXref
id: Q96KP4
db: UniProt

Reference/CAS 501-75-7
type: UnificationXref
id: 501-75-7
db: CAS

Reference/CAS 104-98-3
type: UnificationXref
id: 104-98-3
db: CAS

Protein/650 Cytoplasm/Stoichiometry/8.0
type: Stoichiometry
physical entity: Formimidoyltransferase-cyclodeaminase
stoichiometric coefficient: 8.0

Amiloride-sensitive amine oxidase [copper-containing]
type: Complex
component stoichiometry: Protein/382 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Amiloride-sensitive amine oxidase [copper-containing]

Carnosine synthase 1
type: Complex
component stoichiometry: Protein/4059 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Carnosine synthase 1

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/UniProt P19801
type: UnificationXref
id: P19801
db: UniProt

Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/CAS 645-65-8
type: UnificationXref
id: 645-65-8
db: CAS

Reference/ChEBI CHEBI 29178
type: UnificationXref
id: CHEBI:29178
db: ChEBI

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/UniProt P49590
type: UnificationXref
id: P49590
db: UniProt

Reference/ChemSpider 132948
type: UnificationXref
id: 132948
db: ChemSpider

Reference/UniProt P30838
type: UnificationXref
id: P30838
db: UniProt

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Compound/PW C000749 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C03680
type: UnificationXref
id: C03680
db: KEGG Compound

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Reference/KEGG Compound C01262
type: UnificationXref
id: C01262
db: KEGG Compound

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

L-Histidyl-tRNA(His)
type: RnaReference
xref: Reference/ChEBI CHEBI 29155
organism: Homo sapiens

Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

tRNA(His)
type: RnaReference
xref: Reference/ChEBI CHEBI 29178
organism: Homo sapiens

Formiminoglutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439233
xref: Reference/HMDB HMDB0000854
xref: Reference/KEGG Compound C00439
xref: Reference/ChemSpider 388370
xref: Reference/CAS 816-90-0
xref: Reference/ChEBI CHEBI 7274
xref: Reference/BioCyc N-FORMIMINO-L-GLUTAMATE
chemical formula: C6H10N2O4
molecular weight: 174.06406
structure: ChemicalStructure/PW C000680

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C01152
type: UnificationXref
id: C01152
db: KEGG Compound

Reference/PubChem-compound 3614
type: UnificationXref
id: 3614
db: PubChem-compound

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Compound/PW C000023 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carnosine
stoichiometric coefficient: 1.0

Protein/382 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Amiloride-sensitive amine oxidase [copper-containing]
stoichiometric coefficient: 2.0

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

Reference/ChEBI CHEBI 29155
type: UnificationXref
id: CHEBI:29155
db: ChEBI

Reference/HMDB HMDB0000033
type: UnificationXref
id: HMDB0000033
db: HMDB

Reference/PubChem-compound 774
type: UnificationXref
id: 774
db: PubChem-compound

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

RNA/24 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Histidyl-tRNA(His)
stoichiometric coefficient: 1.0

Probable histidine--tRNA ligase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Probable histidine--tRNA ligase, mitochondrial

Protein arginine N-methyltransferase 3
type: ProteinReference
xref: Reference/UniProt O60678
organism: Homo sapiens

Beta-Ala-His dipeptidase
type: ProteinReference
xref: Reference/UniProt Q96KN2
organism: Homo sapiens

Reference/PubChem-compound 530
type: UnificationXref
id: 530
db: PubChem-compound

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/HMDB HMDB0001014
type: UnificationXref
id: HMDB0001014
db: HMDB

Reference/UniProt P12081
type: UnificationXref
id: P12081
db: UniProt

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylhomocysteine

Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Imidazole-4-acetaldehyde
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05130
xref: Reference/HMDB HMDB0003905
xref: Reference/CAS 645-14-7
xref: Reference/PubChem-compound 150841
xref: Reference/ChemSpider 132948
xref: Reference/ChEBI CHEBI 27398
chemical formula: C5H6N2O
molecular weight: 110.04801
structure: ChemicalStructure/PW C001992

Reference/ChemSpider 83153
type: UnificationXref
id: 83153
db: ChemSpider

Ammonia
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Ammonia

ChemicalStructure/PW C000040
type: ChemicalStructure
structure format: SMILES
structure data: NCCC(O)=O

Reference/BioCyc UROCANATE
type: UnificationXref
id: UROCANATE
db: BioCyc

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Reference/ChemSpider 86856
type: UnificationXref
id: 86856
db: ChemSpider

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Histidinemia
type: Pathway
pathway order: PathwayEnzymeReaction/589
pathway order: PathwayEnzymeReaction/586
pathway order: PathwayEnzymeReaction/597
pathway order: PathwayEnzymeReaction/577078
pathway order: PathwayEnzymeReaction/585
pathway order: PathwayEnzymeReaction/596
pathway order: PathwayEnzymeReaction/577046
pathway order: PathwayEnzymeReaction/588
pathway order: PathwaySubPathway/845
pathway order: PathwayEnzymeReaction/587
pathway order: PathwayEnzymeReaction/593
pathway order: PathwayEnzymeReaction/592
pathway order: PathwayEnzymeReaction/584
pathway order: PathwayEnzymeReaction/595
pathway order: PathwayEnzymeReaction/577047
pathway order: PathwayEnzymeReaction/583
pathway order: PathwayEnzymeReaction/594
pathway order: PathwayEnzymeReaction/591
pathway order: PathwayEnzymeReaction/2512119
pathway component: ReactionCatalysis157
pathway component: ReactionCatalysis454
pathway component: ReactionCatalysis455
pathway component: ReactionCatalysis452
pathway component: ReactionCatalysis453
pathway component: ReactionCatalysis450
pathway component: ReactionCatalysis131
pathway component: ReactionCatalysis451
pathway component: ReactionCatalysis62987
pathway component: ReactionCatalysis62986
pathway component: ReactionCatalysis62988
pathway component: Glutamate Metabolism
pathway component: 2.1.1.8
pathway component: ReactionCatalysis449
pathway component: 1.4.3.4
pathway component: 4.1.1.22
pathway component: 6.1.1.21
pathway component: ReactionCatalysis448
pathway component: 1.2.1.3
pathway component: 6.3.2.11
pathway component: 2.1.1.-
pathway component: Reaction869
pathway component: 4.2.1.49
pathway component: 4.3.1.3
pathway component: ReactionCatalysis460
pathway component: 1.4.3.22
pathway component: Reaction72857
pathway component: Reaction72858
pathway component: 3.4.13.18
pathway component: 3.4.13.20
pathway component: 1.2.1.5
pathway component: ReactionCatalysis458
pathway component: 3.5.2.7
pathway component: ReactionCatalysis459
pathway component: ReactionCatalysis456
pathway component: ReactionCatalysis457
xref: Reference/SMPDB SMP0000191
xref: Reference/PathWhiz PW000113
organism: Homo sapiens

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/HMDB HMDB0000056
type: UnificationXref
id: HMDB0000056
db: HMDB

Reference/HMDB HMDB0000177
type: UnificationXref
id: HMDB0000177
db: HMDB

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Histidine ammonia-lyase
type: Protein
cellular location: Cytoplasm
entity reference: Histidine ammonia-lyase

Glutamate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway845
pathway component: SubPathwayInteraction845
xref: Reference/SMPDB SMP0000072
xref: Reference/PathWhiz PW000003
name: SubPathway

Hydrogen peroxide
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Hydrogen peroxide

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Compound/PW C000126 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Anserine
stoichiometric coefficient: 1.0

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Probable histidine--tRNA ligase, mitochondrial
type: Complex
component stoichiometry: Protein/608 Mitochondrion/Stoichiometry/2.0
cellular location: Mitochondrion
component: Probable histidine--tRNA ligase, mitochondrial

L-Histidine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15971
xref: Reference/HMDB HMDB0000177
xref: Reference/PubChem-compound 6274
xref: Reference/ChemSpider 6038
xref: Reference/CAS 71-00-1
xref: Reference/BioCyc HIS
xref: Reference/KEGG Compound C00135
chemical formula: C6H9N3O2
molecular weight: 155.06947
structure: ChemicalStructure/PW C000116

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/BioCyc HISTAMINE
type: UnificationXref
id: HISTAMINE
db: BioCyc

Compound/PW C000693 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Histamine
stoichiometric coefficient: 1.0

Aldehyde dehydrogenase, dimeric NADP-preferring
type: Protein
cellular location: Cytoplasm
entity reference: Aldehyde dehydrogenase, dimeric NADP-preferring

3-Methylhistidine
type: SmallMoleculeReference
xref: Reference/CAS 368-16-1
xref: Reference/HMDB HMDB0000479
xref: Reference/KEGG Compound C01152
xref: Reference/ChemSpider 58494
xref: Reference/PubChem-compound 64969
xref: Reference/ChEBI CHEBI 27596
chemical formula: C7H11N3O2
molecular weight: 169.08513
structure: ChemicalStructure/PW C000364

1-Methylhistidine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000001
xref: Reference/KEGG Compound C01152
xref: Reference/ChemSpider 83153
xref: Reference/BioCyc CPD-1823
xref: Reference/PubChem-compound 7020397
xref: Reference/ChEBI CHEBI 50599
xref: Reference/CAS 332-80-9
chemical formula: C7H11N3O2
molecular weight: 169.08513
structure: ChemicalStructure/PW C000001

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Urocanic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000301
xref: Reference/ChemSpider 643824
xref: Reference/CAS 104-98-3
xref: Reference/ChEBI CHEBI 30817
xref: Reference/KEGG Compound C00785
xref: Reference/BioCyc UROCANATE
xref: Reference/PubChem-compound 736715
chemical formula: C6H6N2O2
molecular weight: 138.04292
structure: ChemicalStructure/PW C000205

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Carnosine N-methyltransferase
type: Protein
cellular location: Cytosol
entity reference: Carnosine N-methyltransferase

Reference/KEGG Compound C00099
type: UnificationXref
id: C00099
db: KEGG Compound

Histidine ammonia-lyase
type: ProteinReference
xref: Reference/UniProt P42357
organism: Homo sapiens

Reference/ChEBI CHEBI 18295
type: UnificationXref
id: CHEBI:18295
db: ChEBI

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Reference/ChemSpider 753
type: UnificationXref
id: 753
db: ChemSpider

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc CARNOSINE
type: UnificationXref
id: CARNOSINE
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Reference/HMDB HMDB0000194
type: UnificationXref
id: HMDB0000194
db: HMDB

Histamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000870
xref: Reference/ChemSpider 753
xref: Reference/PubChem-compound 774
xref: Reference/BioCyc HISTAMINE
xref: Reference/CAS 51-45-6
xref: Reference/ChEBI CHEBI 18295
xref: Reference/KEGG Compound C00388
chemical formula: C5H9N3
molecular weight: 111.07965
structure: ChemicalStructure/PW C000693

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

5-Formiminotetrahydrofolic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 5-Formiminotetrahydrofolic acid

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Histamine N-methyltransferase
type: ProteinReference
xref: Reference/UniProt P50135
organism: Homo sapiens

Reference/CAS 332-80-9
type: UnificationXref
id: 332-80-9
db: CAS

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Formimidoyltransferase-cyclodeaminase
type: ProteinReference
xref: Reference/UniProt O95954
organism: Homo sapiens

Reference/ChemSpider 167957
type: UnificationXref
id: 167957
db: ChemSpider

ChemicalStructure/PW C001179
type: ChemicalStructure
structure format: SMILES

NAD
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NAD

Reference/HMDB HMDB0002024
type: UnificationXref
id: HMDB0002024
db: HMDB

ReactionCatalysis157
type: Catalysis
controller: Beta-Ala-His dipeptidase
controlled: 3.4.13.20
control type: ACTIVATION

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Histidine decarboxylase
type: ProteinReference
xref: Reference/UniProt P19113
organism: Homo sapiens

Aldehyde dehydrogenase, mitochondrial
type: Protein
cellular location: Cytoplasm
entity reference: Aldehyde dehydrogenase, mitochondrial

Reference/PubChem-compound 128
type: UnificationXref
id: 128
db: PubChem-compound

tRNA(His)
type: Rna
cellular location: Cytoplasm
entity reference: tRNA(His)

Imidazoleacetic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 28305488
xref: Reference/ChEBI CHEBI 16974
xref: Reference/ChemSpider 86856
xref: Reference/BioCyc 4-IMIDAZOLEACETATE
xref: Reference/KEGG Compound C02835
xref: Reference/CAS 645-65-8
xref: Reference/HMDB HMDB0002024
chemical formula: C5H6N2O2
molecular weight: 126.04293
structure: ChemicalStructure/PW C001357

L-Histidyl-tRNA(His)
type: Rna
cellular location: Mitochondrion
entity reference: L-Histidyl-tRNA(His)

ChemicalStructure/PW C000205
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C1=CNC=N1

Histidine decarboxylase
type: Protein
cellular location: Cytoplasm
entity reference: Histidine decarboxylase

ChemicalStructure/PW C000693
type: ChemicalStructure
structure format: SMILES
structure data: NCCC1=CNC=N1

Compound/PW C000749 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Compound/PW C001992 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Imidazole-4-acetaldehyde
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/HMDB HMDB0000898
type: UnificationXref
id: HMDB0000898
db: HMDB

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Compound/PW C001357 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Imidazoleacetic acid
stoichiometric coefficient: 1.0

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

6.1.1.21
type: BiochemicalReaction
participant stoichiometry: RNA/24 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000116 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: RNA/24 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: RNA/23 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: RNA/23 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000116 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrion/Stoichiometry/1.0
right: Pyrophosphate
right: Adenosine monophosphate
right: L-Histidyl-tRNA(His)
spontaneous: false
EC number: 6.1.1.21
left: Adenosine triphosphate
left: tRNA(His)
left: L-Histidine
name: Adenosine triphosphate + L-Histidine + tRNA(His) → Adenosine monophosphate + L-Histidyl-tRNA(His) + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Reference/UniProt Q8N4J0
type: UnificationXref
id: Q8N4J0
db: UniProt

Compound/PW C000001 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1-Methylhistidine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15971
type: UnificationXref
id: CHEBI:15971
db: ChEBI

Compound/PW C000023 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carnosine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 239
type: UnificationXref
id: 239
db: PubChem-compound

4.3.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000035 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000116 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000205 Cytoplasm/Stoichiometry/1.0
right: Ammonia
right: Urocanic acid
spontaneous: false
EC number: 4.3.1.3
left: L-Histidine
name: L-Histidine ↔ Ammonia + Urocanic acid
conversion direction: REVERSIBLE

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Protein/11858 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: cytosolic non-specific dipeptidase
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0000301
type: UnificationXref
id: HMDB0000301
db: HMDB

Reference/ChemSpider 125
type: UnificationXref
id: 125
db: ChemSpider

Ammonia
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Ammonia

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/ChEBI CHEBI 15727
type: UnificationXref
id: CHEBI:15727
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

β-Alanine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000056
xref: Reference/ChemSpider 234
xref: Reference/PubChem-compound 239
xref: Reference/ChEBI CHEBI 16958
xref: Reference/KEGG Compound C00099
xref: Reference/CAS 107-95-9
xref: Reference/BioCyc B-ALANINE
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000040

Reference/PubChem-compound 28305488
type: UnificationXref
id: 28305488
db: PubChem-compound

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Probable histidine--tRNA ligase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P49590
organism: Homo sapiens

Anserine
type: SmallMoleculeReference
xref: Reference/CAS 584-85-0
xref: Reference/PubChem-compound 112072
xref: Reference/KEGG Compound C01262
xref: Reference/ChemSpider 100482
xref: Reference/HMDB HMDB0000194
xref: Reference/ChEBI CHEBI 18323
chemical formula: C10H16N4O3
molecular weight: 240.12224
structure: ChemicalStructure/PW C000126

Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 6038
type: UnificationXref
id: 6038
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Tetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 20506
xref: Reference/ChemSpider 18714427
xref: Reference/HMDB HMDB0001846
xref: Reference/PubChem-compound 13781857
xref: Reference/BioCyc THF
xref: Reference/CAS 135-16-0
xref: Reference/KEGG Compound C00101
chemical formula: C19H23N7O6
molecular weight: 445.171
structure: ChemicalStructure/PW C001221

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

RNA/23 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA(His)
stoichiometric coefficient: 1.0

β-Alanine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: β-Alanine

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Imidazole-4-acetaldehyde
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Imidazole-4-acetaldehyde

2.1.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000116 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000364 Cytoplasm/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: 3-Methylhistidine
spontaneous: false
EC number: 2.1.1.-
left: S-Adenosylmethionine
left: L-Histidine
name: L-Histidine + S-Adenosylmethionine → 3-Methylhistidine + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

cytosolic non-specific dipeptidase
type: Complex
component stoichiometry: Protein/11858 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: cytosolic non-specific dipeptidase

SubPathwayInteraction845
type: Interaction
name: SubPathway845Reaction
name: SubPathwayReaction
participant: L-Glutamic acid

Methylimidazole acetaldehyde
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Methylimidazole acetaldehyde

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Urocanate hydratase
type: ProteinReference
xref: Reference/UniProt Q96N76
organism: Homo sapiens

Reference/CAS 305-84-0
type: UnificationXref
id: 305-84-0
db: CAS

Histidine--tRNA ligase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt P12081
organism: Homo sapiens

Compound/PW C000921 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000680
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC[C@H](NC=N)C(O)=O

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0001534
type: UnificationXref
id: HMDB0001534
db: HMDB

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Carnosine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 439224
xref: Reference/BioCyc CARNOSINE
xref: Reference/KEGG Compound C00386
xref: Reference/CAS 305-84-0
xref: Reference/ChEBI CHEBI 15727
xref: Reference/HMDB HMDB0000033
xref: Reference/ChemSpider 388363
chemical formula: C9H14N4O3
molecular weight: 226.1066
structure: ChemicalStructure/PW C000023

3.4.13.20
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000040 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000116 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000023 Cytoplasm/Stoichiometry/1.0
right: β-Alanine
right: L-Histidine
spontaneous: false
EC number: 3.4.13.20
left: Carnosine
left: Water
name: Carnosine + Water → L-Histidine + β-Alanine
conversion direction: LEFT_TO_RIGHT

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Reference/BioCyc THF
type: UnificationXref
id: THF
db: BioCyc

Reference/BioCyc N-FORMIMINO-L-GLUTAMATE
type: UnificationXref
id: N-FORMIMINO-L-GLUTAMATE
db: BioCyc

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/ChEBI CHEBI 16974
type: UnificationXref
id: CHEBI:16974
db: ChEBI

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: S-Adenosylhomocysteine

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

ChemicalStructure/PW C000126
type: ChemicalStructure
structure format: SMILES
structure data: CN1C=NC=C1C[C@H](NC(=O)CCN)C(O)=O

Reference/CAS 71-00-1
type: UnificationXref
id: 71-00-1
db: CAS

Probable imidazolonepropionase
type: ProteinReference
xref: Reference/UniProt Q96NU7
organism: Homo sapiens

Reference/KEGG Compound C05127
type: UnificationXref
id: C05127
db: KEGG Compound

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

Reference/UniProt O95954
type: UnificationXref
id: O95954
db: UniProt

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

ChemicalStructure/PW C001221
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Water

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05130
type: UnificationXref
id: C05130
db: KEGG Compound

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/ChEBI CHEBI 15639
type: UnificationXref
id: CHEBI:15639
db: ChEBI

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

tRNA(His)
type: Rna
cellular location: Mitochondrion
entity reference: tRNA(His)

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

1.4.3.22
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001992 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000693 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Mitochondrion/Stoichiometry/1.0
right: Ammonia
right: Hydrogen peroxide
right: Imidazole-4-acetaldehyde
spontaneous: false
EC number: 1.4.3.22
left: Histamine
left: Water
left: Oxygen
name: Histamine + Oxygen + Water → Ammonia + Hydrogen peroxide + Imidazole-4-acetaldehyde
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Compound/PW C001065 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001357
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CC1=CN=CN1

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

5-Formiminotetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/CAS 2311-81-1
xref: Reference/HMDB HMDB0001534
xref: Reference/BioCyc 5-FORMIMINO-THF
xref: Reference/ChemSpider 11267158
xref: Reference/ChEBI CHEBI 15639
xref: Reference/KEGG Compound C00664
xref: Reference/PubChem-compound 530
chemical formula: C20H24N8O6
molecular weight: 472.1819
structure: ChemicalStructure/PW C001179

Compound/PW C000170 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000023
type: ChemicalStructure
structure format: SMILES
structure data: NCCC(=O)N[C@@H](CC1=CN=CN1)C(O)=O

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/CAS 107-95-9
type: UnificationXref
id: 107-95-9
db: CAS

Oxygen
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxygen

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

1-Methylhistamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 1-Methylhistamine

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/ChemSpider 234
type: UnificationXref
id: 234
db: ChemSpider

Reference/HMDB HMDB0000479
type: UnificationXref
id: HMDB0000479
db: HMDB

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen peroxide

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/UniProt P21397
type: UnificationXref
id: P21397
db: UniProt

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/BioCyc 5-FORMIMINO-THF
type: UnificationXref
id: 5-FORMIMINO-THF
db: BioCyc

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Compound/PW C000032 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reaction869
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000680 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001179 Cytoplasm/Stoichiometry/1.0
right: L-Glutamic acid
right: 5-Formiminotetrahydrofolic acid
spontaneous: false
left: Formiminoglutamic acid
left: Tetrahydrofolic acid
name: Formiminoglutamic acid + Tetrahydrofolic acid ↔ 5-Formiminotetrahydrofolic acid + L-Glutamic acid
conversion direction: REVERSIBLE

4.2.1.49
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000205 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000802 Cytoplasm/Stoichiometry/1.0
right: Water
right: Urocanic acid
spontaneous: false
EC number: 4.2.1.49
left: 4-Imidazolone-5-propionic acid
name: 4-Imidazolone-5-propionic acid ↔ Urocanic acid + Water
conversion direction: REVERSIBLE

Protein/4059 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Carnosine synthase 1
stoichiometric coefficient: 4.0

ChemicalStructure/PW C000116
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC1=CN=CN1)C(O)=O

Compound/PW C000680 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Formiminoglutamic acid
stoichiometric coefficient: 1.0

Reference/CAS 816-90-0
type: UnificationXref
id: 816-90-0
db: CAS

Reference/SMPDB SMP0000072
type: UnificationXref
id: SMP0000072
db: SMPDB

Reference/HMDB HMDB0000001
type: UnificationXref
id: HMDB0000001
db: HMDB

Reference/SMPDB SMP0000191
type: UnificationXref
id: SMP0000191
db: SMPDB

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

ChemicalStructure/PW C000364
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@](N)(CC1=CN=CN1C)C(O)=O

ChemicalStructure/PW C000001
type: ChemicalStructure
structure format: SMILES
structure data: CN1C=NC(C[C@H](N)C(O)=O)=C1

Reference/ChEBI CHEBI 16958
type: UnificationXref
id: CHEBI:16958
db: ChEBI

Compound/PW C000205 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Urocanic acid
stoichiometric coefficient: 1.0

Compound/PW C001420 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Protein/608 Mitochondrion/Stoichiometry/2.0
type: Stoichiometry
physical entity: Probable histidine--tRNA ligase, mitochondrial
stoichiometric coefficient: 2.0

NADH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADH

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/CAS 51-45-6
type: UnificationXref
id: 51-45-6
db: CAS

L-Histidine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Histidine

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Beta-Ala-His dipeptidase
type: Complex
component stoichiometry: Protein/456 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Beta-Ala-His dipeptidase

Protein/456 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Beta-Ala-His dipeptidase
stoichiometric coefficient: 2.0

Carnosine synthase 1
type: Protein
cellular location: Cytosol
entity reference: Carnosine synthase 1

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Histamine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Histamine

Reference/HMDB HMDB0004181
type: UnificationXref
id: HMDB0004181
db: HMDB

RNA/23 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA(His)
stoichiometric coefficient: 1.0

Reference/UniProt P05091
type: UnificationXref
id: P05091
db: UniProt

Reference/BioCyc B-ALANINE
type: UnificationXref
id: B-ALANINE
db: BioCyc

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/BioCyc N-METHYL-HISTAMINE
type: UnificationXref
id: N-METHYL-HISTAMINE
db: BioCyc

Reference/ChemSpider 68319
type: UnificationXref
id: 68319
db: ChemSpider

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylmethionine

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Compound/PW C000040 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-Alanine
stoichiometric coefficient: 1.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

1.2.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001712 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002083 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: Methylimidazoleacetic acid
right: NADPH
spontaneous: false
EC number: 1.2.1.5
left: Water
left: Methylimidazole acetaldehyde
left: NADP
name: Methylimidazole acetaldehyde + NADP + Water → Hydrogen Ion + Methylimidazoleacetic acid + NADPH
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 150841
type: UnificationXref
id: 150841
db: PubChem-compound

Urocanate hydratase
type: Protein
cellular location: Cytoplasm
entity reference: Urocanate hydratase

NADPH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADPH

ReactionCatalysis454
type: Catalysis
controller: Amiloride-sensitive amine oxidase [copper-containing]
controlled: 1.4.3.22
control type: ACTIVATION

ReactionCatalysis455
type: Catalysis
controller: Aldehyde dehydrogenase, mitochondrial
controlled: 1.2.1.3
control type: ACTIVATION

cytosolic non-specific dipeptidase
type: Protein
cellular location: Cytosol
entity reference: cytosolic non-specific dipeptidase

ReactionCatalysis452
type: Catalysis
controller: Amine oxidase [flavin-containing] A
controlled: 1.4.3.4
control type: ACTIVATION

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

ReactionCatalysis453
type: Catalysis
controller: Aldehyde dehydrogenase, dimeric NADP-preferring
controlled: 1.2.1.5
control type: ACTIVATION

Reference/CAS 584-85-0
type: UnificationXref
id: 584-85-0
db: CAS

ReactionCatalysis450
type: Catalysis
controller: Histidine decarboxylase
controlled: 4.1.1.22
control type: ACTIVATION

ReactionCatalysis451
type: Catalysis
controller: Histamine N-methyltransferase
controlled: 2.1.1.8
control type: ACTIVATION

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Protein arginine N-methyltransferase 3
type: Protein
cellular location: Cytoplasm
entity reference: Protein arginine N-methyltransferase 3

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Reference/UniProt O60678
type: UnificationXref
id: O60678
db: UniProt

Reference/ChEBI CHEBI 30817
type: UnificationXref
id: CHEBI:30817
db: ChEBI

Compound/PW C001221 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrofolic acid
stoichiometric coefficient: 1.0

Amiloride-sensitive amine oxidase [copper-containing]
type: Protein
cellular location: Mitochondrion
entity reference: Amiloride-sensitive amine oxidase [copper-containing]

ReactionCatalysis449
type: Catalysis
controller: Protein arginine N-methyltransferase 3
controlled: 2.1.1.-
control type: ACTIVATION

Reference/BioCyc HIS
type: UnificationXref
id: HIS
db: BioCyc

ReactionCatalysis448
type: Catalysis
controller: Carnosine synthase 1
controlled: 6.3.2.11
control type: ACTIVATION

1.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001992 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001357 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: NADH
right: Imidazoleacetic acid
spontaneous: false
EC number: 1.2.1.3
left: Imidazole-4-acetaldehyde
left: Water
left: NAD
name: Imidazole-4-acetaldehyde + NAD + Water → Hydrogen Ion + Imidazoleacetic acid + NADH
conversion direction: LEFT_TO_RIGHT

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

ChemicalStructure/PW C000717
type: ChemicalStructure
structure format: SMILES
structure data: CN1C=NC(CCN)=C1

Probable imidazolonepropionase
type: Protein
cellular location: Cytoplasm
entity reference: Probable imidazolonepropionase

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Adenosine monophosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Adenosine monophosphate

Histidine--tRNA ligase, cytoplasmic
type: Protein
cellular location: Cytoplasm
entity reference: Histidine--tRNA ligase, cytoplasmic

Reference/ChEBI CHEBI 50599
type: UnificationXref
id: CHEBI:50599
db: ChEBI

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

β-Alanine
type: SmallMolecule
cellular location: Cytosol
entity reference: β-Alanine

Carnosine synthase 1
type: Protein
cellular location: Cytoplasm
entity reference: Carnosine synthase 1

4-Imidazolone-5-propionic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 4-Imidazolone-5-propionic acid

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Compound/PW C001783 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Formiminoglutamic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Formiminoglutamic acid

Reference/BioCyc 4-IMIDAZOLEACETATE
type: UnificationXref
id: 4-IMIDAZOLEACETATE
db: BioCyc

Compound/PW C001783 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/PubChem-compound 439233
type: UnificationXref
id: 439233
db: PubChem-compound

Reference/UniProt P42357
type: UnificationXref
id: P42357
db: UniProt

Reference/HMDB HMDB0000854
type: UnificationXref
id: HMDB0000854
db: HMDB

2.1.1.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000693 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000717 Cytoplasm/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: 1-Methylhistamine
spontaneous: false
EC number: 2.1.1.8
left: Histamine
left: S-Adenosylmethionine
name: Histamine + S-Adenosylmethionine → 1-Methylhistamine + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Compound/PW C000116 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Histidine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 27596
type: UnificationXref
id: CHEBI:27596
db: ChEBI

Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/CAS 368-16-1
type: UnificationXref
id: 368-16-1
db: CAS

Pyrophosphate
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Pyrophosphate

6.3.2.11
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000116 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000040 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000023 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Carnosine
right: Adenosine diphosphate
right: Phosphate
spontaneous: false
EC number: 6.3.2.11
left: Adenosine triphosphate
left: β-Alanine
left: L-Histidine
name: Adenosine triphosphate + L-Histidine + β-Alanine → Adenosine diphosphate + Carnosine + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Amine oxidase [flavin-containing] A
type: Protein
cellular location: Cytoplasm
entity reference: Amine oxidase [flavin-containing] A

Reference/CAS 2625-49-2
type: UnificationXref
id: 2625-49-2
db: CAS

ReactionCatalysis460
type: Catalysis
controller: Probable histidine--tRNA ligase, mitochondrial
controlled: 6.1.1.21
control type: ACTIVATION

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Compound/PW C000040 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: β-Alanine
stoichiometric coefficient: 1.0

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

Reference/PubChem-compound 439224
type: UnificationXref
id: 439224
db: PubChem-compound

Reaction72857
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000126 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000023 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
right: S-Adenosylhomocysteine
right: Anserine
spontaneous: false
left: Carnosine
left: S-Adenosylmethionine
name: Carnosine + S-Adenosylmethionine → Anserine + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Reaction72858
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000126 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000040 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000001 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Adenosine diphosphate
right: Anserine
spontaneous: false
left: 1-Methylhistidine
left: Adenosine triphosphate
left: β-Alanine
name: 1-Methylhistidine + Adenosine triphosphate + β-Alanine → Adenosine diphosphate + Anserine + Phosphate
conversion direction: LEFT_TO_RIGHT

3.4.13.18
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000126 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000040 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000001 Cytosol/Stoichiometry/1.0
right: 1-Methylhistidine
right: β-Alanine
spontaneous: false
EC number: 3.4.13.18
left: Anserine
left: Water
name: Anserine + Water → 1-Methylhistidine + β-Alanine
conversion direction: LEFT_TO_RIGHT

Compound/PW C001712 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methylimidazoleacetic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

ChemicalStructure/PW C001992
type: ChemicalStructure
structure format: SMILES
structure data: O=CCC1=CN=CN1

Reference/CAS 645-14-7
type: UnificationXref
id: 645-14-7
db: CAS

ReactionCatalysis458
type: Catalysis
controller: Formimidoyltransferase-cyclodeaminase
controlled: Reaction869
control type: ACTIVATION

3.5.2.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000802 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000680 Cytoplasm/Stoichiometry/1.0
right: Formiminoglutamic acid
spontaneous: false
EC number: 3.5.2.7
left: Water
left: 4-Imidazolone-5-propionic acid
name: 4-Imidazolone-5-propionic acid + Water → Formiminoglutamic acid
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis459
type: Catalysis
controller: Histidine--tRNA ligase, cytoplasmic
controlled: 6.1.1.21
control type: ACTIVATION

ReactionCatalysis456
type: Catalysis
controller: Urocanate hydratase
controlled: 4.2.1.49
control type: ACTIVATION

Reference/PubChem-compound 736715
type: UnificationXref
id: 736715
db: PubChem-compound

ReactionCatalysis457
type: Catalysis
controller: Probable imidazolonepropionase
controlled: 3.5.2.7
control type: ACTIVATION

ReactionCatalysis131
type: Catalysis
controller: Histidine ammonia-lyase
controlled: 4.3.1.3
control type: ACTIVATION

Reference/KEGG Compound C02835
type: UnificationXref
id: C02835
db: KEGG Compound

Reference/PathWhiz PW000003
type: UnificationXref
id: PW000003
db: PathWhiz

ChemicalStructure/PW C001712
type: ChemicalStructure
structure format: SMILES
structure data: CN1C=NC(CC(O)=O)=C1

Methylimidazoleacetic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Methylimidazoleacetic acid

Reference/ChemSpider 388370
type: UnificationXref
id: 388370
db: ChemSpider

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000870
type: UnificationXref
id: HMDB0000870
db: HMDB

Reference/CAS 2311-81-1
type: UnificationXref
id: 2311-81-1
db: CAS

Reference/PubChem-compound 75810
type: UnificationXref
id: 75810
db: PubChem-compound

Reference/PubChem-compound 112072
type: UnificationXref
id: 112072
db: PubChem-compound

Protein/289 Cytoplasm/Stoichiometry/4.0
type: Stoichiometry
physical entity: Aldehyde dehydrogenase, mitochondrial
stoichiometric coefficient: 4.0

4.1.1.22
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000116 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001316 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000693 Cytoplasm/Stoichiometry/1.0
right: Carbon dioxide
right: Histamine
spontaneous: false
EC number: 4.1.1.22
left: L-Histidine
name: L-Histidine → Carbon dioxide + Histamine
conversion direction: LEFT_TO_RIGHT

Compound/PW C000364 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Methylhistidine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Histamine N-methyltransferase
type: Protein
cellular location: Cytoplasm
entity reference: Histamine N-methyltransferase

Reference/PathWhiz PW000113
type: UnificationXref
id: PW000113
db: PathWhiz

Protein/828 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Histidine decarboxylase
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0003905
type: UnificationXref
id: HMDB0003905
db: HMDB

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/HMDB HMDB0001846
type: UnificationXref
id: HMDB0001846
db: HMDB

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

Reference/KEGG Compound C00785
type: UnificationXref
id: C00785
db: KEGG Compound

Reference/KEGG Compound C00664
type: UnificationXref
id: C00664
db: KEGG Compound

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

Reference/HMDB HMDB0002820
type: UnificationXref
id: HMDB0002820
db: HMDB

Reference/UniProt P19113
type: UnificationXref
id: P19113
db: UniProt

Compound/PW C000116 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Histidine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 13781857
type: UnificationXref
id: 13781857
db: PubChem-compound

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: S-Adenosylmethionine

Reference/BioCyc CPD-1823
type: UnificationXref
id: CPD-1823
db: BioCyc

Reference/PubChem-compound 7020397
type: UnificationXref
id: 7020397
db: PubChem-compound

Methylimidazole acetaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28104
xref: Reference/CAS 19639-03-3
xref: Reference/ChemSpider 167957
xref: Reference/HMDB HMDB0004181
xref: Reference/KEGG Compound C05827
xref: Reference/PubChem-compound 193545
chemical formula: C6H8N2O
molecular weight: 124.06366
structure: ChemicalStructure/PW C002083

Anserine
type: SmallMolecule
cellular location: Cytosol
entity reference: Anserine