ReactionCatalysis155
ACTIVATION
1.0
Fibrinogen beta chain
Coagulation factor V
Ardeparin Action Pathway
5284607
PubChem-compound
Fibrin (loose)
82688
ChemSpider
PW000297
PathWhiz
ReactionCatalysis142
ACTIVATION
4447652
ChemSpider
Antithrombin-III
Fibrin (mesh)
ReactionCatalysis381
ACTIVATION
Prothrombin and coagulation factors VII, IX and X
SMILES
CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CC1=C(O)C2=C(C=CC=C2)C(O)=C1C
P00488
UniProt
Vitamin K-dependent gamma-carboxylase
P02671
UniProt
BTO:0000759
BRENDA TISSUE ONTOLOGY
Fibrinogen gamma chain
Tenase complex
Coagulation factor VIII
Coagulation factor IX
ReactionCatalysis1103
ACTIVATION
2.3.2.13
false
2.3.2.13
Fibrin (loose) → Fibrin (mesh)
LEFT_TO_RIGHT
Coagulation factor VIII
ReactionCatalysis1105
ACTIVATION
HMDB0002972
HMDB
3.4.21.5
false
3.4.21.5
Fibrinogen → Fibrin (loose)
LEFT_TO_RIGHT
P02675
UniProt
1.1.4.1
false
1.1.4.1
Vitamin K1 2,3-epoxide → Reduced Vitamin K (phylloquinone)
LEFT_TO_RIGHT
ReactionCatalysis1100
ACTIVATION
P02679
UniProt
1.0
Tissue factor
Collagen alpha-1(I) chain
ReactionCatalysis1115
ACTIVATION
3.4.21.5
false
3.4.21.5
Coagulation factor V → Coagulation factor Va
LEFT_TO_RIGHT
3.4.21.5
false
3.4.21.5
Coagulation factor VIII → Coagulation factor VIIIa
LEFT_TO_RIGHT
3.4.21.22
false
3.4.21.22
Coagulation factor X → Coagulation factor Xa
LEFT_TO_RIGHT
1.0
Precursors of Prothrombin and coagulation factors VII, IX, ad X
Reaction1389
false
Prothrombin → Thrombin
LEFT_TO_RIGHT
3.4.21.38
false
3.4.21.38
Coagulation factor XI → Coagulation factor XIa
LEFT_TO_RIGHT
ReactionCatalysis1110
ACTIVATION
SubPathwayControl184
ActivatingSubPathwayControl
SubPathway184Control
SubPathwayControl186
ActivatingSubPathwayControl
SubPathway186Control
SubPathwayControl188
ActivatingSubPathwayControl
SubPathway188Control
3.4.21.27
false
3.4.21.27
Coagulation factor IX → Coagulation factor IXa
LEFT_TO_RIGHT
Prothrombin and coagulation factors VII, IX and X
Ardeparin
SubPathwayActivator
Vitamin K1 2,3-epoxide
84-80-0
CAS
91577
PubChem-compound
Coagulation factor X
Vitamin K epoxide reductase complex subunit 1
Coagulation factor VIIa
SubPathwayActivator
Plasminogen
Liver
25486-55-9
CAS
C26H42N2O37S5
Ardeparin
1134.007
Coagulation factor IX
P03951
UniProt
P03952
UniProt
P00451
UniProt
1.0
Extracellular Space
Blood Vessel
BiologicalState51
Homo sapiens, Blood Vessel
Coagulation factor XIIa
GO:0005615
GENE ONTOLOGY
XII activated to XIIa by Collagen
ActivatingSubPathway
Transport80
false
Prothrombin and coagulation factors VII, IX and X (→) Transport: Homo sapiens, Liver, Cell to Homo sapiens, Blood Vessel
LEFT_TO_RIGHT
XII activated to XIIa by Plasma kallikrein
ActivatingSubPathway
1.0
Coagulation factor X
CHEBI:28371
ChEBI
Plasma prekallikrein activated to Plasma kallikrein by XIIa
ActivatingSubPathway
C05849
KEGG Compound
BiologicalState29
Homo sapiens, Liver
1.0
Coagulation factor XIII B chain
Tissue-type plasminogen activator
Ardeparin activation of Antithrombin-III
ActivatingSubPathway
P00750
UniProt
4.1.1.90
false
4.1.1.90
Precursors of Prothrombin and coagulation factors VII, IX, ad X → Prothrombin and coagulation factors VII, IX and X
LEFT_TO_RIGHT
1.0
Plasminogen
Activate Coagulatin factor VII to VIIa by binding to Tissue Factor
ActivatingSubPathway
4.1.1.90
false
4.1.1.90
Reduced Vitamin K (phylloquinone) → Vitamin K1 2,3-epoxide
LEFT_TO_RIGHT
3.4.21.68
false
3.4.21.68
Plasminogen → Plasmin
LEFT_TO_RIGHT
Fibrinogen alpha chain
Plasma kallikrein
SubPathwayActivation
C05850
KEGG Compound
Fibrinogen gamma chain
1.0
Coagulation factor XIII B chain
SubPathwayActivator
1.0
BTO:0001102
BRENDA TISSUE ONTOLOGY
1.0
3.4.21.7
false
3.4.21.7
Fibrin (mesh) → Fibrin degradation products
LEFT_TO_RIGHT
P38435
UniProt
Coagulation factor XIa
Coagulation factor XIII A chain
SubPathwayActivator
Coagulation factor X
Vitamin K epoxide reductase complex subunit 1
Coagulation factor VIIa
Homo sapiens
1.0
Vitamin K-dependent gamma-carboxylase
HMDB0014551
HMDB
P13726
UniProt
Antithrombin-III
SubPathwayActivation
HMDB0004198
HMDB
Q9BQB6
UniProt
Fibrinogen
23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ
BioCyc
C31H46O3
Vitamin K1 2,3-epoxide
466.3447
772
PubChem-compound
1.0
P08709
UniProt
SMP0000275
SMPDB
9606
TAXONOMY
Collagen alpha-1(I) chain
SubPathwayActivator
Coagulation factor XIIa
P12259
UniProt
P02452
UniProt
Coagulation factor XIIIa
SubPathwayActivation
1.0
P05160
UniProt
ReactionCatalysis1126
ACTIVATION
ReactionCatalysis1125
ACTIVATION
ReactionCatalysis1129
ACTIVATION
1.0
Coagulation factor V
P01008
UniProt
ReactionCatalysis1124
ACTIVATION
Fibrin degradation products
SMILES
CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\C[C@@]12O[C@]1(C)C(=O)C1=C(C=CC=C1)C2=O
Coagulation factor XIII A chain
Coagulation factor XIII A chain
Tissue factor:Coagulation factor VIIa
SubPathwayActivation
Precursors of Prothrombin and coagulation factors VII, IX, ad X
SubPathwayControl216
SubPathway216Control
ActivatingSubPathwayControl
Prothrombin and coagulation factors VII, IX and X
1.0
Coagulation factor XIa
Thrombin
ReactionCatalysis1134
ACTIVATION
Plasma kallikrein
Tissue-type plasminogen activator
Coagulation factor XIIIa
Tissue factor
SubPathwayActivator
Coagulation factor XIII B chain
Fibrinogen alpha chain
Fibrinogen beta chain
751
ChemSpider
1.0
Thrombin
P00734
UniProt
Coagulation factor XIII A and B activate to Coagulation factor XIIIa
ActivatingSubPathway
SubPathwayControl470
ActivatingSubPathwayControl
SubPathway470Control
Coagulation factor XIIa
SubPathwayActivation
SubPathwayActivator
Vitamin K-dependent gamma-carboxylase
SubPathwayControl235
SubPathway235Control
ActivatingSubPathwayControl
1.0
Plasma kallikrein
SubPathwayActivator
CHEBI:18067
ChEBI
P00747
UniProt
Reduced Vitamin K (phylloquinone)
P00748
UniProt
Coagulation factor XIa
C31H48O2
Reduced Vitamin K (phylloquinone)
452.36542
SMILES
CC(=O)NC1C(O)OC(COS(O)(=O)=O)C(OC2OC(C(OC3OC(CO)C(OC4OC(C(O)C(O)C4OS(O)(=O)=O)C(O)=O)C(OS(O)(=O)=O)C3NS(O)(=O)=O)C(O)C2OS(O)(=O)=O)C(O)=O)C1O
P00740
UniProt
P00742
UniProt