ReactionCatalysis155
type: Catalysis
controller: Coagulation factor XIIa
controlled: 3.4.21.38
control type: ACTIVATION

Compound/PW C002089/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced Vitamin K (phylloquinone)
stoichiometric coefficient: 1.0

Fibrinogen beta chain
type: Protein
cellular location: Extracellular Space
entity reference: Fibrinogen beta chain

Coagulation factor V
type: ProteinReference
xref: Reference/UniProt P12259
organism: Homo sapiens

Reference/PubChem-compound 5284607
type: UnificationXref
id: 5284607
db: PubChem-compound

Fibrin (loose)
type: Complex
cellular location: Extracellular Space
component: Fibrinogen alpha chain
component: Fibrinogen beta chain
component: Fibrinogen gamma chain

Aminocaproic Acid inhibition of Plasminogen
type: Pathway
name: InhibitorySubPathway

Reference/ChemSpider 82688
type: UnificationXref
id: 82688
db: ChemSpider

ReactionCatalysis142
type: Catalysis
controller: Vitamin K epoxide reductase complex subunit 1
controlled: 1.1.4.1
control type: ACTIVATION

Reference/ChemSpider 4447652
type: UnificationXref
id: 4447652
db: ChemSpider

Fibrin (mesh)
type: Complex
cellular location: Extracellular Space
component: Fibrinogen alpha chain
component: Fibrinogen beta chain
component: Fibrinogen gamma chain

ReactionCatalysis381
type: Catalysis
controller: Coagulation factor XIa
controlled: 3.4.21.27
control type: ACTIVATION

Aminocaproic Acid Action Pathway
type: Pathway
pathway order: PathwaySubPathway/235
pathway order: PathwaySubPathway/188
pathway order: PathwaySubPathway/186
pathway order: PathwaySubPathway/184
pathway order: PathwayEnzymeReaction/1481
pathway order: PathwayEnzymeReaction/1480
pathway order: PathwaySubPathway/216
pathway order: PathwaySubPathway/511
pathway order: PathwayEnzymeReaction/1473
pathway order: PathwayEnzymeReaction/1501
pathway order: PathwayTransport/1521
pathway order: PathwayEnzymeReaction/1456
pathway order: PathwayEnzymeReaction/1467
pathway order: PathwayEnzymeReaction/1488
pathway order: PathwayEnzymeReaction/1510
pathway order: PathwayEnzymeReaction/1503
pathway order: PathwayEnzymeReaction/1337
pathway order: PathwayEnzymeReaction/1469
pathway order: PathwayEnzymeReaction/1502
pathway order: PathwayEnzymeReaction/1508
pathway order: PathwayEnzymeReaction/1518
pathway component: SubPathwayControl184
pathway component: ReactionCatalysis155
pathway component: SubPathwayControl186
pathway component: SubPathwayControl188
pathway component: 3.4.21.27
pathway component: ReactionCatalysis1126
pathway component: ReactionCatalysis1103
pathway component: 2.3.2.13
pathway component: ReactionCatalysis1125
pathway component: ReactionCatalysis1105
pathway component: ReactionCatalysis1129
pathway component: 3.4.21.5
pathway component: 1.1.4.1
pathway component: 4.1.1.90
pathway component: ReactionCatalysis1100
pathway component: ReactionCatalysis1124
pathway component: ReactionCatalysis142
pathway component: 3.4.21.68
pathway component: SubPathwayControl235
pathway component: SubPathwayControl511
pathway component: ReactionCatalysis381
pathway component: SubPathwayControl216
pathway component: ReactionCatalysis1115
pathway component: Transport80
pathway component: 3.4.21.22
pathway component: 3.4.21.7
pathway component: Reaction1389
pathway component: 3.4.21.38
pathway component: ReactionCatalysis1110
pathway component: ReactionCatalysis1134
xref: Reference/SMPDB SMP0000286
xref: Reference/PathWhiz PW000308
organism: Homo sapiens

Prothrombin and coagulation factors VII, IX and X
type: Protein
entity reference: Prothrombin and coagulation factors VII, IX and X

ChemicalStructure/PW C002089
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P00488
type: UnificationXref
id: P00488
db: UniProt

Vitamin K-dependent gamma-carboxylase
type: Protein
cellular location: Extracellular Space
entity reference: Vitamin K-dependent gamma-carboxylase

Reference/UniProt P02671
type: UnificationXref
id: P02671
db: UniProt

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Fibrinogen gamma chain
type: ProteinReference
xref: Reference/UniProt P02679
organism: Homo sapiens

Tenase complex
type: Complex
cellular location: Extracellular Space
component: Coagulation factor VIII
component: Coagulation factor IX

Coagulation factor VIII
type: ProteinReference
xref: Reference/UniProt P00451
organism: Homo sapiens

Coagulation factor IX
type: ProteinReference
xref: Reference/UniProt P00740
organism: Homo sapiens

ReactionCatalysis1103
type: Catalysis
controller: Thrombin
controlled: 3.4.21.5
control type: ACTIVATION

2.3.2.13
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/635 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/637 Extracellular Space/Stoichiometry/1.0
right: Fibrin (mesh)
spontaneous: false
EC number: 2.3.2.13
left: Fibrin (loose)
name: Fibrin (loose) → Fibrin (mesh)
conversion direction: LEFT_TO_RIGHT

Coagulation factor VIII
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor VIII

ReactionCatalysis1105
type: Catalysis
controller: Thrombin
controlled: 3.4.21.5
control type: ACTIVATION

Reference/HMDB HMDB0002972
type: UnificationXref
id: HMDB0002972
db: HMDB

3.4.21.5
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/635 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/634 Extracellular Space/Stoichiometry/1.0
right: Fibrin (loose)
spontaneous: false
EC number: 3.4.21.5
left: Fibrinogen
name: Fibrinogen → Fibrin (loose)
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P02675
type: UnificationXref
id: P02675
db: UniProt

1.1.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002089/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001746/Stoichiometry/1.0
right: Reduced Vitamin K (phylloquinone)
spontaneous: false
EC number: 1.1.4.1
left: Vitamin K1 2,3-epoxide
name: Vitamin K1 2,3-epoxide → Reduced Vitamin K (phylloquinone)
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1100
type: Catalysis
controller: Tenase complex
controlled: 3.4.21.22
control type: ACTIVATION

Reference/UniProt P02679
type: UnificationXref
id: P02679
db: UniProt

Protein/5692 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thrombin
stoichiometric coefficient: 1.0

Tissue factor
type: ProteinReference
xref: Reference/UniProt P13726

Collagen alpha-1(I) chain
type: ProteinReference
xref: Reference/UniProt P02452
organism: Homo sapiens

ReactionCatalysis1115
type: Catalysis
controller: Coagulation factor XIIIa
controlled: 2.3.2.13
control type: ACTIVATION

3.4.21.5
type: BiochemicalReaction
participant stoichiometry: Protein/1795 Extracellular Space/Stoichiometry/1.0
right: Coagulation factor V
spontaneous: false
EC number: 3.4.21.5
left: Coagulation factor V
name: Coagulation factor V → Coagulation factor Va
conversion direction: LEFT_TO_RIGHT

3.4.21.5
type: BiochemicalReaction
participant stoichiometry: Protein/1570 Extracellular Space/Stoichiometry/1.0
right: Coagulation factor VIII
spontaneous: false
EC number: 3.4.21.5
left: Coagulation factor VIII
name: Coagulation factor VIII → Coagulation factor VIIIa
conversion direction: LEFT_TO_RIGHT

3.4.21.22
type: BiochemicalReaction
participant stoichiometry: Protein/1730 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/1730/Stoichiometry/1.0
right: Coagulation factor X
spontaneous: false
EC number: 3.4.21.22
left: Coagulation factor X
name: Coagulation factor X → Coagulation factor Xa
conversion direction: LEFT_TO_RIGHT

ProteinComplex/641 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrin degradation products
stoichiometric coefficient: 1.0

Precursors of Prothrombin and coagulation factors VII, IX, ad X
type: Protein
cellular location: Extracellular Space
entity reference: Precursors of Prothrombin and coagulation factors VII, IX, ad X

Reaction1389
type: BiochemicalReaction
participant stoichiometry: Protein/5692 Extracellular Space/Stoichiometry/1.0
right: Thrombin
spontaneous: false
left: Thrombin
name: Prothrombin → Thrombin
conversion direction: LEFT_TO_RIGHT

3.4.21.38
type: BiochemicalReaction
participant stoichiometry: Protein/5691/Stoichiometry/1.0
right: Coagulation factor XIa
spontaneous: false
EC number: 3.4.21.38
left: Coagulation factor XIa
name: Coagulation factor XI → Coagulation factor XIa
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1110
type: Catalysis
controller: Thrombin
controlled: 3.4.21.5
control type: ACTIVATION

SubPathwayControl184
type: Interaction
name: ActivatingSubPathwayControl
name: SubPathway184Control
participant: Collagen alpha-1(I) chain
participant: Coagulation factor XIIa
participant: XII activated to XIIa by Collagen

SubPathwayControl186
type: Interaction
name: ActivatingSubPathwayControl
name: SubPathway186Control
participant: Coagulation factor XIIa
participant: XII activated to XIIa by Plasma kallikrein
participant: Plasma kallikrein

SubPathwayControl188
type: Interaction
name: ActivatingSubPathwayControl
name: SubPathway188Control
participant: Coagulation factor XIIa
participant: Plasma prekallikrein activated to Plasma kallikrein by XIIa
participant: Plasma kallikrein

3.4.21.27
type: BiochemicalReaction
participant stoichiometry: Protein/1571 Extracellular Space/Stoichiometry/1.0
right: Coagulation factor IX
spontaneous: false
EC number: 3.4.21.27
left: Coagulation factor IX
name: Coagulation factor IX → Coagulation factor IXa
conversion direction: LEFT_TO_RIGHT

Prothrombin and coagulation factors VII, IX and X
type: Protein
cellular location: Extracellular Space
entity reference: Prothrombin and coagulation factors VII, IX and X

Vitamin K1 2,3-epoxide
type: SmallMolecule
entity reference: Vitamin K1 2,3-epoxide

Reference/CAS 84-80-0
type: UnificationXref
id: 84-80-0
db: CAS

Reference/SMPDB SMP0000286
type: UnificationXref
id: SMP0000286
db: SMPDB

Reference/PubChem-compound 91577
type: UnificationXref
id: 91577
db: PubChem-compound

Coagulation factor X
type: Protein
entity reference: Coagulation factor X

Vitamin K epoxide reductase complex subunit 1
type: Protein
entity reference: Vitamin K epoxide reductase complex subunit 1

Coagulation factor VIIa
type: Protein
entity reference: Coagulation factor VIIa
name: SubPathwayActivator

Plasminogen
type: Protein
cellular location: Extracellular Space
entity reference: Plasminogen
name: SubPathwayInhibition

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Reference/CAS 25486-55-9
type: UnificationXref
id: 25486-55-9
db: CAS

Coagulation factor IX
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor IX

Reference/UniProt P03951
type: UnificationXref
id: P03951
db: UniProt

Reference/UniProt P03952
type: UnificationXref
id: P03952
db: UniProt

Reference/UniProt P00451
type: UnificationXref
id: P00451
db: UniProt

ProteinComplex/637 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrin (mesh)
stoichiometric coefficient: 1.0

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Blood Vessel
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0001102

Aminocaproic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 517030
xref: Reference/ChEBI CHEBI 16586
xref: Reference/CAS 60-32-2
xref: Reference/KEGG Compound C02378
xref: Reference/HMDB HMDB0001901
xref: Reference/ChemSpider 548
chemical formula: C6H13NO2
molecular weight: 131.09464
structure: ChemicalStructure/PW C001268

BiologicalState51
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Blood Vessel
tissue: Blood Vessel

SubPathwayControl511
type: Interaction
name: SubPathway511Control
name: InhibitorySubPathwayControl
participant: Aminocaproic acid
participant: Aminocaproic Acid inhibition of Plasminogen
participant: Plasminogen

Coagulation factor XIIa
type: Protein
entity reference: Coagulation factor XIIa

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

XII activated to XIIa by Collagen
type: Pathway
name: ActivatingSubPathway

Transport80
type: Transport
participant stoichiometry: Protein/Generic45/Stoichiometry/1.0
right: Prothrombin and coagulation factors VII, IX and X
spontaneous: false
left: Prothrombin and coagulation factors VII, IX and X
name: Prothrombin and coagulation factors VII, IX and X (→) Transport: Homo sapiens, Liver, Cell to Homo sapiens, Blood Vessel
conversion direction: LEFT_TO_RIGHT

XII activated to XIIa by Plasma kallikrein
type: Pathway
name: ActivatingSubPathway

Compound/PW C001746/Stoichiometry/1.0
type: Stoichiometry
physical entity: Vitamin K1 2,3-epoxide
stoichiometric coefficient: 1.0

Coagulation factor X
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor X

Reference/ChEBI CHEBI 28371
type: UnificationXref
id: CHEBI:28371
db: ChEBI

Plasma prekallikrein activated to Plasma kallikrein by XIIa
type: Pathway
name: ActivatingSubPathway

Reference/KEGG Compound C05849
type: UnificationXref
id: C05849
db: KEGG Compound

BiologicalState29
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver
tissue: Liver

Protein/1570 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor VIII
stoichiometric coefficient: 1.0

Coagulation factor XIII B chain
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor XIII B chain

Tissue-type plasminogen activator
type: Protein
cellular location: Extracellular Space
entity reference: Tissue-type plasminogen activator

ChemicalStructure/PW C001268
type: ChemicalStructure
structure format: SMILES
structure data: NCCCCCC(O)=O

Reference/UniProt P00750
type: UnificationXref
id: P00750
db: UniProt

4.1.1.90
type: BiochemicalReaction
participant stoichiometry: Protein/Generic45 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Protein/Generic44 Extracellular Space/Stoichiometry/1.0
right: Prothrombin and coagulation factors VII, IX and X
spontaneous: false
EC number: 4.1.1.90
left: Precursors of Prothrombin and coagulation factors VII, IX, ad X
name: Precursors of Prothrombin and coagulation factors VII, IX, ad X → Prothrombin and coagulation factors VII, IX and X
conversion direction: LEFT_TO_RIGHT

Plasminogen
type: ProteinReference
xref: Reference/UniProt P00747
organism: Homo sapiens

Protein/5691/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor XIa
stoichiometric coefficient: 1.0

Activate Coagulatin factor VII to VIIa by binding to Tissue Factor
type: Pathway
name: ActivatingSubPathway

4.1.1.90
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002089/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001746/Stoichiometry/1.0
right: Vitamin K1 2,3-epoxide
spontaneous: false
EC number: 4.1.1.90
left: Reduced Vitamin K (phylloquinone)
name: Reduced Vitamin K (phylloquinone) → Vitamin K1 2,3-epoxide
conversion direction: LEFT_TO_RIGHT

3.4.21.68
type: BiochemicalReaction
participant stoichiometry: Protein/1716 Extracellular Space/Stoichiometry/1.0
right: Plasminogen
spontaneous: false
EC number: 3.4.21.68
left: Plasminogen
name: Plasminogen → Plasmin
conversion direction: LEFT_TO_RIGHT

Fibrinogen alpha chain
type: Protein
cellular location: Extracellular Space
entity reference: Fibrinogen alpha chain

Reference/HMDB HMDB0001901
type: UnificationXref
id: HMDB0001901
db: HMDB

Plasma kallikrein
type: Protein
entity reference: Plasma kallikrein
name: SubPathwayActivation

Reference/KEGG Compound C05850
type: UnificationXref
id: C05850
db: KEGG Compound

Fibrinogen gamma chain
type: Protein
cellular location: Extracellular Space
entity reference: Fibrinogen gamma chain

Reference/PubChem-compound 517030
type: UnificationXref
id: 517030
db: PubChem-compound

Protein/1730 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor X
stoichiometric coefficient: 1.0

Coagulation factor XIII B chain
type: Protein
entity reference: Coagulation factor XIII B chain
name: SubPathwayActivator

Protein/1716 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Plasminogen
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0001102
type: UnificationXref
id: BTO:0001102
db: BRENDA TISSUE ONTOLOGY

Reference/CAS 60-32-2
type: UnificationXref
id: 60-32-2
db: CAS

Protein/Generic45/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prothrombin and coagulation factors VII, IX and X
stoichiometric coefficient: 1.0

3.4.21.7
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/641 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/637 Extracellular Space/Stoichiometry/1.0
right: Fibrin degradation products
spontaneous: false
EC number: 3.4.21.7
left: Fibrin (mesh)
name: Fibrin (mesh) → Fibrin degradation products
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P38435
type: UnificationXref
id: P38435
db: UniProt

Coagulation factor XIa
type: Protein
entity reference: Coagulation factor XIa

Coagulation factor XIII A chain
type: Protein
entity reference: Coagulation factor XIII A chain
name: SubPathwayActivator

Coagulation factor X
type: ProteinReference
xref: Reference/UniProt P00742
organism: Homo sapiens

Vitamin K epoxide reductase complex subunit 1
type: ProteinReference
xref: Reference/UniProt Q9BQB6

Coagulation factor VIIa
type: ProteinReference
xref: Reference/UniProt P08709

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ProteinComplex/635 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrin (loose)
stoichiometric coefficient: 1.0

Vitamin K-dependent gamma-carboxylase
type: Protein
entity reference: Vitamin K-dependent gamma-carboxylase

Reference/UniProt P13726
type: UnificationXref
id: P13726
db: UniProt

Reference/HMDB HMDB0004198
type: UnificationXref
id: HMDB0004198
db: HMDB

Reference/UniProt Q9BQB6
type: UnificationXref
id: Q9BQB6
db: UniProt

Fibrinogen
type: Complex
cellular location: Extracellular Space
component: Fibrinogen alpha chain
component: Fibrinogen beta chain
component: Fibrinogen gamma chain

Reference/BioCyc 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ
type: UnificationXref
id: 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ
db: BioCyc

Vitamin K1 2,3-epoxide
type: SmallMoleculeReference
xref: Reference/ChemSpider 82688
xref: Reference/HMDB HMDB0002972
xref: Reference/CAS 25486-55-9
xref: Reference/PubChem-compound 91577
xref: Reference/KEGG Compound C05849
xref: Reference/ChEBI CHEBI 28371
xref: Reference/BioCyc 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ
chemical formula: C31H46O3
molecular weight: 466.3447
structure: ChemicalStructure/PW C001746

Reference/ChemSpider 548
type: UnificationXref
id: 548
db: ChemSpider

Protein/1730/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor X
stoichiometric coefficient: 1.0

Reference/UniProt P08709
type: UnificationXref
id: P08709
db: UniProt

Reference/PathWhiz PW000308
type: UnificationXref
id: PW000308
db: PathWhiz

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Collagen alpha-1(I) chain
type: Protein
cellular location: Extracellular Space
entity reference: Collagen alpha-1(I) chain
name: SubPathwayActivator

Coagulation factor XIIa
type: ProteinReference
xref: Reference/UniProt P00748

Reference/UniProt P12259
type: UnificationXref
id: P12259
db: UniProt

Reference/UniProt P02452
type: UnificationXref
id: P02452
db: UniProt

Coagulation factor XIIIa
type: Complex
component: Coagulation factor XIII B chain
component: Coagulation factor XIII A chain
name: SubPathwayActivation

Reference/KEGG Compound C02378
type: UnificationXref
id: C02378
db: KEGG Compound

ProteinComplex/634 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fibrinogen
stoichiometric coefficient: 1.0

Reference/UniProt P05160
type: UnificationXref
id: P05160
db: UniProt

ReactionCatalysis1126
type: Catalysis
controller: Tissue factor:Coagulation factor VIIa
controlled: 3.4.21.22
control type: ACTIVATION

ReactionCatalysis1125
type: Catalysis
controller: Tissue-type plasminogen activator
controlled: 3.4.21.68
control type: ACTIVATION

ReactionCatalysis1129
type: Catalysis
controller: Vitamin K-dependent gamma-carboxylase
controlled: 4.1.1.90
control type: ACTIVATION

Protein/Generic44 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Precursors of Prothrombin and coagulation factors VII, IX, ad X
stoichiometric coefficient: 1.0

Coagulation factor V
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor V

ReactionCatalysis1124
type: Catalysis
controller: Plasminogen
controlled: 3.4.21.7
control type: ACTIVATION

Fibrin degradation products
type: Complex
cellular location: Extracellular Space
component: Fibrinogen alpha chain
component: Fibrinogen beta chain
component: Fibrinogen gamma chain

Reference/ChEBI CHEBI 16586
type: UnificationXref
id: CHEBI:16586
db: ChEBI

ChemicalStructure/PW C001746
type: ChemicalStructure
structure format: SMILES

Coagulation factor XIII A chain
type: ProteinReference
xref: Reference/UniProt P00488
organism: Homo sapiens

Coagulation factor XIII A chain
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor XIII A chain

Tissue factor:Coagulation factor VIIa
type: Complex
component: Coagulation factor VIIa
component: Tissue factor
name: SubPathwayActivation

Precursors of Prothrombin and coagulation factors VII, IX, ad X
type: ProteinReference
xref: Reference/UniProt P00734
organism: Homo sapiens

SubPathwayControl216
type: Interaction
name: SubPathway216Control
name: ActivatingSubPathwayControl
participant: Coagulation factor XIII B chain
participant: Coagulation factor XIIIa
participant: Coagulation factor XIII A chain
participant: Coagulation factor XIII A and B activate to Coagulation factor XIIIa

Prothrombin and coagulation factors VII, IX and X
type: ProteinReference
xref: Reference/UniProt P00734
organism: Homo sapiens

Protein/1571 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor IX
stoichiometric coefficient: 1.0

Coagulation factor XIa
type: ProteinReference
xref: Reference/UniProt P03951

Thrombin
type: ProteinReference
xref: Reference/UniProt P00734
organism: Homo sapiens

ReactionCatalysis1134
type: Catalysis
controller: Vitamin K-dependent gamma-carboxylase
controlled: 4.1.1.90
control type: ACTIVATION

Plasma kallikrein
type: ProteinReference
xref: Reference/UniProt P03952
organism: Homo sapiens

Tissue-type plasminogen activator
type: ProteinReference
xref: Reference/UniProt P00750
organism: Homo sapiens

Coagulation factor XIIIa
type: Complex
cellular location: Extracellular Space
component: Coagulation factor XIII B chain
component: Coagulation factor XIII A chain

Tissue factor
type: Protein
entity reference: Tissue factor
name: SubPathwayActivator

Coagulation factor XIII B chain
type: ProteinReference
xref: Reference/UniProt P05160
organism: Homo sapiens

Fibrinogen alpha chain
type: ProteinReference
xref: Reference/UniProt P02671
organism: Homo sapiens

Fibrinogen beta chain
type: ProteinReference
xref: Reference/UniProt P02675
organism: Homo sapiens

Protein/Generic45 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Prothrombin and coagulation factors VII, IX and X
stoichiometric coefficient: 1.0

Thrombin
type: Protein
cellular location: Extracellular Space
entity reference: Thrombin

Aminocaproic acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Aminocaproic acid
name: SubPathwayInhibitor

Reference/UniProt P00734
type: UnificationXref
id: P00734
db: UniProt

Coagulation factor XIII A and B activate to Coagulation factor XIIIa
type: Pathway
name: ActivatingSubPathway

Coagulation factor XIIa
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor XIIa
name: SubPathwayActivation
name: SubPathwayActivator

Vitamin K-dependent gamma-carboxylase
type: ProteinReference
xref: Reference/UniProt P38435

SubPathwayControl235
type: Interaction
name: SubPathway235Control
name: ActivatingSubPathwayControl
participant: Tissue factor:Coagulation factor VIIa
participant: Coagulation factor VIIa
participant: Tissue factor
participant: Activate Coagulatin factor VII to VIIa by binding to Tissue Factor

Protein/1795 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coagulation factor V
stoichiometric coefficient: 1.0

Plasma kallikrein
type: Protein
cellular location: Extracellular Space
entity reference: Plasma kallikrein
name: SubPathwayActivator

Reference/ChEBI CHEBI 18067
type: UnificationXref
id: CHEBI:18067
db: ChEBI

Reference/UniProt P00747
type: UnificationXref
id: P00747
db: UniProt

Reduced Vitamin K (phylloquinone)
type: SmallMolecule
entity reference: Reduced Vitamin K (phylloquinone)

Reference/UniProt P00748
type: UnificationXref
id: P00748
db: UniProt

Coagulation factor XIa
type: Protein
cellular location: Extracellular Space
entity reference: Coagulation factor XIa

Reduced Vitamin K (phylloquinone)
type: SmallMoleculeReference
xref: Reference/PubChem-compound 5284607
xref: Reference/ChemSpider 4447652
xref: Reference/HMDB HMDB0004198
xref: Reference/KEGG Compound C05850
xref: Reference/ChEBI CHEBI 18067
xref: Reference/CAS 84-80-0
chemical formula: C31H48O2
molecular weight: 452.36542
structure: ChemicalStructure/PW C002089

Reference/UniProt P00740
type: UnificationXref
id: P00740
db: UniProt

Reference/UniProt P00742
type: UnificationXref
id: P00742
db: UniProt