Sodium/potassium-transporting ATPase subunit alpha-3
type: ProteinReference
xref: Reference/UniProt P13637

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

ReactionCoupledTransportCatalysis4
type: Catalysis
controller: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
controlled: 3.6.3.8
control type: ACTIVATION

Voltage-gated slow delayed rectifying potassium channel (IK5)
type: Complex
component: Potassium voltage-gated channel subfamily KQT member 1
component: Potassium voltage-gated channel subfamily E member 1

Voltage-gated ultra rapid delayed rectifying potassium channel
type: Complex
component: Disks large homolog 1
component: Potassium voltage-gated channel subfamily A member 5

Disks large homolog 1
type: Protein
entity reference: Disks large homolog 1

Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto)
type: Complex
component: Kv channel-interacting protein 2
component: Potassium voltage-gated channel subfamily D member 3

ATP-binding cassette sub-family C member 9
type: Protein
entity reference: ATP-binding cassette sub-family C member 9

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Sodium/potassium-transporting ATPase subunit beta-3
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-3

Acetylcholine-activated potassium channel (IKACh)
type: Complex
component: G protein-activated inward rectifier potassium channel 4
component: G protein-activated inward rectifier potassium channel 1
name: SubPathwayActivation

Inward rectifier potassium channel (IK1)
type: Complex
component: Inward rectifier potassium channel 2
component: Inward rectifier potassium channel 4

Potassium voltage-gated channel subfamily A member 5
type: Protein
entity reference: Potassium voltage-gated channel subfamily A member 5

TransportCatalysis93
type: Catalysis
controller: Voltage-gated T-type calcium channel (ICaT)
controlled: Transport35
control type: ACTIVATION

TransportCatalysis92
type: Catalysis
controller: Voltage-gated sodium channel (INa)
controlled: Transport62
control type: ACTIVATION

direct_interaction
type: InteractionVocabulary

TransportCatalysis91
type: Catalysis
controller: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
controlled: Transport120
control type: ACTIVATION

TransportCatalysis90
type: Catalysis
controller: Sodium/calcium exchanger 1
controlled: Transport119
control type: ACTIVATION

Sodium/calcium exchanger 1
type: Protein
entity reference: Sodium/calcium exchanger 1

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: Protein
entity reference: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
name: SubPathwayInhibition

Transport119
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
right: Sodium
spontaneous: false
left: Sodium
left: Calcium
name: Calcium (→), Sodium (←) Transport: Homo sapiens, Cardiomyocyte, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/UniProt O00180
type: UnificationXref
id: O00180
db: UniProt

Transport116
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Cardiomyocyte, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reaction179579
type: BiochemicalReaction
participant stoichiometry: Protein/Generic536 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: BoundComplex/507 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium_Troponin
spontaneous: false
left: Troponin
left: Calcium
name: Calcium + Troponin → Calcium + Troponin
conversion direction: LEFT_TO_RIGHT

Transport120
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

TransportCatalysis9
type: Catalysis
controller: Voltage-depenent L-type calcium channel
controlled: Transport35
control type: ACTIVATION

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

Voltage-gated T-type calcium channel (ICaT)
type: Complex
component: Voltage-dependent T-type calcium channel subunit alpha-1G
component: Voltage-dependent T-type calcium channel subunit alpha-1H

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium
name: SubPathwayActivator

Voltage-gated sodium channel (INa)
type: Complex
component: Sodium channel protein type 5 subunit alpha
component: Beta-1-syntrophin
component: Beta-2-syntrophin
component: Alpha-1-syntrophin

Reference/UniProt P48544
type: UnificationXref
id: P48544
db: UniProt

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Voltage-depenent L-type calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/1845/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent L-type calcium channel subunit alpha-1C

Reference/UniProt P63252
type: UnificationXref
id: P63252
db: UniProt

Inward rectifier potassium channel 2
type: Protein
entity reference: Inward rectifier potassium channel 2

Voltage-depenent L-type calcium channel
type: Complex
component stoichiometry: Protein/1845 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2706 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2720 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit alpha-1C
component: Voltage-dependent L-type calcium channel subunit beta-1
name: SubPathwayActivation

Reference/UniProt P48549
type: UnificationXref
id: P48549
db: UniProt

ATP-sensitive inward rectifier potassium channel (IKATP)
type: Complex
component: ATP-sensitive inward rectifier potassium channel 8
component: ATP-binding cassette sub-family C member 8
component: ATP-sensitive inward rectifier potassium channel 11
component: ATP-binding cassette sub-family C member 9

Voltage-gated rapid delayed rectifying potassium channel (IKr)
type: Complex
component: Potassium voltage-gated channel subfamily E member 2
component: Potassium voltage-gated channel subfamily H member 2
component: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

Reference/UniProt Q5I7T1
type: UnificationXref
id: Q5I7T1
db: UniProt

Ryanodine receptor 2
type: ProteinReference
xref: Reference/UniProt Q92736

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Ryanodine receptor 2
type: Protein
cellular location: Sarcoplasmic Reticulum
entity reference: Ryanodine receptor 2

SubPathwayInteraction109962
type: Interaction
name: SubPathwayReaction
name: SubPathway109962Reaction
participant: Tropomyosin

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Compound/PW C001420 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

Reference/UniProt P05023
type: UnificationXref
id: P05023
db: UniProt

Reference/UniProt P05026
type: UnificationXref
id: P05026
db: UniProt

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Reference/UniProt O60706
type: UnificationXref
id: O60706
db: UniProt

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/UniProt P14415
type: UnificationXref
id: P14415
db: UniProt

ATP-binding cassette sub-family C member 8
type: ProteinReference
xref: Reference/UniProt Q09428

Reference/HMDB HMDB0015004
type: UnificationXref
id: HMDB0015004
db: HMDB

Calcium_Troponin
type: Complex
component stoichiometry: Protein/Generic536 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Troponin
component: Calcium

Alprenolol Action Pathway
type: Pathway
pathway order: PathwaySubPathway/319
pathway order: PathwaySubPathway/318
pathway order: PathwaySubPathway/109962
pathway order: PathwayTransport/1653
pathway order: PathwayTransport/1630
pathway order: PathwayTransport/1652
pathway order: PathwayTransport/1655
pathway order: PathwayTransport/1656
pathway order: PathwayInteraction/2851
pathway order: PathwaySubPathway/322
pathway order: PathwaySubPathway/320
pathway order: PathwaySubPathway/321
pathway order: PathwaySubPathway/428
pathway order: PathwayTransport/1660
pathway order: PathwayTransport/1662
pathway order: PathwayTransport/1661
pathway order: PathwaySubPathway/325
pathway order: PathwayTransport/1664
pathway order: PathwayEnzymeReaction/2123351
pathway order: PathwayTransport/1665
pathway order: PathwayTransport/1646
pathway order: PathwayTransport/1645
pathway order: PathwayTransport/1667
pathway order: PathwayTransport/1648
pathway order: PathwayTransport/1649
pathway order: PathwayEnzymeReaction/211631
pathway component: SubPathwayControl320
pathway component: SubPathwayControl321
pathway component: ReactionCoupledTransportCatalysis4
pathway component: SubPathwayControl322
pathway component: SubPathwayControl325
pathway component: Interaction2851
pathway component: TransportCatalysis10
pathway component: SubPathwayControl428
pathway component: Muscle Contraction
pathway component: TransportCatalysis93
pathway component: TransportCatalysis92
pathway component: TransportCatalysis91
pathway component: TransportCatalysis90
pathway component: Transport119
pathway component: Transport116
pathway component: Reaction179579
pathway component: Transport120
pathway component: TransportCatalysis9
pathway component: Transport35
pathway component: TransportCatalysis23
pathway component: TransportCatalysis89
pathway component: TransportCatalysis88
pathway component: TransportCatalysis87
pathway component: Transport36
pathway component: Transport53
pathway component: SubPathwayControl318
pathway component: SubPathwayControl319
pathway component: TransportCatalysis82
pathway component: 3.6.3.8
pathway component: Transport62
pathway component: TransportCatalysis86
pathway component: TransportCatalysis85
pathway component: TransportCatalysis84
pathway component: TransportCatalysis83
xref: Reference/PathWhiz PW000365
xref: Reference/SMPDB SMP0000297
organism: Homo sapiens

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Sodium channel protein type 5 subunit alpha
type: ProteinReference
xref: Reference/UniProt Q14524

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

Protein/2720 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

Protein/3291 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tropomyosin beta chain
stoichiometric coefficient: 1.0

Reference/UniProt Q13936
type: UnificationXref
id: Q13936
db: UniProt

Reference/UniProt O43497
type: UnificationXref
id: O43497
db: UniProt

Adenosine diphosphate
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Adenosine diphosphate

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: ProteinReference
xref: Reference/UniProt B7ZKV8

Alprenolol Inhibition of Beta-1 adrenergic receptor
type: Pathway
name: InhibitorySubPathway

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Sodium/potassium ATPase
type: Complex
component: Sodium/potassium-transporting ATPase subunit beta-2
component: Sodium/potassium-transporting ATPase subunit alpha-1
component: ATPase, (Na+)/K+ transporting, beta 4 polypeptide
component: Sodium/potassium-transporting ATPase subunit beta-1
component: Sodium/potassium-transporting ATPase subunit gamma
component: Sodium/potassium-transporting ATPase subunit alpha-4
component: Sodium/potassium-transporting ATPase subunit alpha-2
component: Sodium/potassium-transporting ATPase subunit beta-3
component: Sodium/potassium-transporting ATPase subunit alpha-3

Reference/CELL TYPE ONTOLOGY CL 0000746
type: UnificationXref
id: CL:0000746
db: CELL TYPE ONTOLOGY

Sodium/potassium-transporting ATPase subunit beta-2
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-2

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

Sodium/potassium-transporting ATPase subunit beta-1
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-1

Reference/PubChem-compound 2119
type: UnificationXref
id: 2119
db: PubChem-compound

Protein/3195/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Phosphate
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Phosphate

Reference/UniProt P48050
type: UnificationXref
id: P48050
db: UniProt

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Reference/UniProt Q92736
type: UnificationXref
id: Q92736
db: UniProt

BiologicalState65
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Heart
tissue: Heart

Sodium/potassium-transporting ATPase subunit gamma
type: ProteinReference
xref: Reference/UniProt P54710

Reference/UniProt P22460
type: UnificationXref
id: P22460
db: UniProt

Potassium voltage-gated channel subfamily H member 2
type: Protein
entity reference: Potassium voltage-gated channel subfamily H member 2

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Protein/3290 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tropomyosin alpha-1 chain
stoichiometric coefficient: 1.0

Beta-1-syntrophin
type: ProteinReference
xref: Reference/UniProt Q13884

Water
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Water

Muscle Contraction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109962
pathway component: SubPathwayInteraction109962
name: SubPathway

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Troponin
type: ProteinReference
organism: BiologicalState50

Reference/ChEBI CHEBI 51211
type: UnificationXref
id: CHEBI:51211
db: ChEBI

Beta-2-syntrophin
type: Protein
entity reference: Beta-2-syntrophin

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Alpha-1-syntrophin
type: Protein
entity reference: Alpha-1-syntrophin

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Alprenolol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 2119
xref: Reference/CAS 13655-52-2
xref: Reference/ChemSpider 2035
xref: Reference/HMDB HMDB0015004
xref: Reference/ChEBI CHEBI 51211
chemical formula: C15H23NO2
molecular weight: 249.17288
structure: ChemicalStructure/PW C009320

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/UniProt Q13884
type: UnificationXref
id: Q13884
db: UniProt

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit
name: SubPathwayActivation

ATP-binding cassette sub-family C member 9
type: ProteinReference
xref: Reference/UniProt O60706

Sodium/potassium-transporting ATPase subunit beta-3
type: ProteinReference
xref: Reference/UniProt P54709

Potassium voltage-gated channel subfamily A member 5
type: ProteinReference
xref: Reference/UniProt P22460

Disks large homolog 1
type: ProteinReference
xref: Reference/UniProt Q12959

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Sodium/potassium-transporting ATPase subunit alpha-4
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-4

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: ProteinReference
xref: Reference/UniProt P16615
organism: BiologicalState47

Sodium/calcium exchanger 1
type: ProteinReference
xref: Reference/UniProt P32418

Transport53
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/2.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Potassium voltage-gated channel subfamily KQT member 1
type: Protein
entity reference: Potassium voltage-gated channel subfamily KQT member 1

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/UniProt P13637
type: UnificationXref
id: P13637
db: UniProt

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/UniProt P09493
type: UnificationXref
id: P09493
db: UniProt

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Sodium/potassium-transporting ATPase subunit alpha-1
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-1

Transport62
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
type: Protein
entity reference: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Cardiomyocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000746

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Reference/SMPDB SMP0000297
type: UnificationXref
id: SMP0000297
db: SMPDB

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

Voltage-dependent T-type calcium channel subunit alpha-1G
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1G

Inward rectifier potassium channel 2
type: ProteinReference
xref: Reference/UniProt P63252

Voltage-dependent T-type calcium channel subunit alpha-1H
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1H

BiologicalState47
type: BioSource
cell type: Cardiomyocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Cardiomyocyte

Reference/UniProt P54710
type: UnificationXref
id: P54710
db: UniProt

Muscarinic acetylcholine receptor M2
type: ProteinReference
xref: Reference/UniProt P08172
organism: BiologicalState47

Protein/2706 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 1.0

Reference/ChemSpider 2035
type: UnificationXref
id: 2035
db: ChemSpider

Reference/UniProt P08172
type: UnificationXref
id: P08172
db: UniProt

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

ATP-sensitive inward rectifier potassium channel 11
type: Protein
entity reference: ATP-sensitive inward rectifier potassium channel 11

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Alprenolol
type: SmallMolecule
entity reference: Alprenolol
name: SubPathwayInhibitor

BiologicalState50
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Muscle, Myocyte
tissue: Muscle

Reference/UniProt Q9NS61
type: UnificationXref
id: Q9NS61
db: UniProt

Reference/UniProt P15382
type: UnificationXref
id: P15382
db: UniProt

Reference/UniProt Q13733
type: UnificationXref
id: Q13733
db: UniProt

Reference/UniProt Q9UK17
type: UnificationXref
id: Q9UK17
db: UniProt

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Beta-1 adrenergic receptor
type: Protein
entity reference: Beta-1 adrenergic receptor
name: SubPathwayInhibition

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P17612
organism: BiologicalState47

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Adenosine triphosphate
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Adenosine triphosphate

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Troponin
type: Protein
cellular location: Cytoplasm
entity reference: Troponin

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

Compound/PW C000458 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Potassium voltage-gated channel subfamily E member 2
type: Protein
entity reference: Potassium voltage-gated channel subfamily E member 2

Sodium/potassium-transporting ATPase subunit beta-1
type: ProteinReference
xref: Reference/UniProt P05026

Kv channel-interacting protein 2
type: Protein
entity reference: Kv channel-interacting protein 2

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

TransportCatalysis10
type: Catalysis
controller: Ryanodine receptor 2
controlled: Transport36
control type: ACTIVATION

Sodium/potassium-transporting ATPase subunit beta-2
type: ProteinReference
xref: Reference/UniProt P14415

SubPathwayControl428
type: Interaction
name: SubPathway428Control
name: InhibitorySubPathwayControl
participant: Alprenolol Inhibition of Beta-1 adrenergic receptor
participant: Alprenolol
participant: Beta-1 adrenergic receptor

Reference/UniProt B7ZKV8
type: UnificationXref
id: B7ZKV8
db: UniProt

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Potassium voltage-gated channel subfamily E member 1
type: Protein
entity reference: Potassium voltage-gated channel subfamily E member 1

Reference/UniProt P51787
type: UnificationXref
id: P51787
db: UniProt

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Reference/UniProt Q14524
type: UnificationXref
id: Q14524
db: UniProt

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/3195/Stoichiometry/4.0
component: Ryanodine receptor 2

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Potassium channel subfamily K member 1
type: Protein
entity reference: Potassium channel subfamily K member 1

Reference/UniProt P07951
type: UnificationXref
id: P07951
db: UniProt

G protein-activated inward rectifier potassium channel 4
type: Protein
entity reference: G protein-activated inward rectifier potassium channel 4

Voltage-dependent L-type calcium channel subunit alpha-1C
type: ProteinReference
xref: Reference/UniProt Q13936

Reference/UniProt Q14654
type: UnificationXref
id: Q14654
db: UniProt

Potassium voltage-gated channel subfamily H member 2
type: ProteinReference
xref: Reference/UniProt Q12809

Heart
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000562

Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

Protein/1845/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit alpha-1C
stoichiometric coefficient: 1.0

TransportCatalysis23
type: Catalysis
controller: Sodium/potassium ATPase
controlled: Transport53
control type: ACTIVATION

Beta-2-syntrophin
type: ProteinReference
xref: Reference/UniProt Q13425

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Potassium voltage-gated channel subfamily D member 3
type: Protein
entity reference: Potassium voltage-gated channel subfamily D member 3

Reference/UniProt P54709
type: UnificationXref
id: P54709
db: UniProt

Inward rectifier potassium channel 4
type: Protein
entity reference: Inward rectifier potassium channel 4

Alpha-1-syntrophin
type: ProteinReference
xref: Reference/UniProt Q13424

G protein-activated inward rectifier potassium channel 1
type: Protein
entity reference: G protein-activated inward rectifier potassium channel 1

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Cardiac phospholamban
type: Complex
component stoichiometry: Protein/2026 Sarcoplasmic Reticulum/Stoichiometry/5.0
cellular location: Sarcoplasmic Reticulum
component: Cardiac phospholamban
name: SubPathwayInhibitor

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/CAS 13655-52-2
type: UnificationXref
id: 13655-52-2
db: CAS

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Potassium voltage-gated channel subfamily KQT member 1
type: ProteinReference
xref: Reference/UniProt P51787

Compound/PW C001104 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

SubPathwayControl320
type: Interaction
name: ActivatingSubPathwayControl
name: SubPathway320Control
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: cAMP-dependent protein kinase type I-alpha regulatory subunit
participant: G-protein signalling cascade
participant: Beta-1 adrenergic receptor

Sodium/potassium-transporting ATPase subunit alpha-4
type: ProteinReference
xref: Reference/UniProt Q13733

SubPathwayControl321
type: Interaction
name: SubPathway321Control
name: ActivatingSubPathwayControl
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel
participant: Voltage-depenent L-type calcium channel

Protein/Generic536 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Troponin
stoichiometric coefficient: 1.0

SubPathwayControl322
type: Interaction
name: ActivatingSubPathwayControl
name: SubPathway322Control
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: Ryanodine receptor 2
participant: cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

SubPathwayControl325
type: Interaction
name: SubPathway325Control
name: ActivatingSubPathwayControl
participant: Ryanodine receptor 2
participant: Calcium
participant: Calcium activates Ryanodine receptor 2

Sodium/potassium-transporting ATPase subunit alpha-2
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-2

Cardiac phospholamban
type: ProteinReference
xref: Reference/UniProt P26678
organism: BiologicalState47

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
type: ProteinReference
xref: Reference/UniProt Q9Y3Q4

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Sodium/potassium-transporting ATPase subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P05023

Protein/3195 Sarcoplasmic Reticulum/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

ATP-sensitive inward rectifier potassium channel 8
type: Protein
entity reference: ATP-sensitive inward rectifier potassium channel 8

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Tropomyosin
type: Complex
component stoichiometry: Protein/3291 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/3290 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Tropomyosin alpha-1 chain
component: Tropomyosin beta chain
name: SubPathwayInput

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Beta-1 adrenergic receptor
type: Protein
cellular location: Cell Membrane
entity reference: Beta-1 adrenergic receptor
name: SubPathwayActivator

Reference/UniProt Q15842
type: UnificationXref
id: Q15842
db: UniProt

Voltage-dependent T-type calcium channel subunit alpha-1G
type: ProteinReference
xref: Reference/UniProt O43497

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Transport35
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/3195 Sarcoplasmic Reticulum/Stoichiometry/4.0
cellular location: Sarcoplasmic Reticulum
component: Ryanodine receptor 2
name: SubPathwayActivation

ATP-sensitive inward rectifier potassium channel 11
type: ProteinReference
xref: Reference/UniProt Q14654

Transport36
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (?) Transport: Homo sapiens, Cardiomyocyte, Sarcoplasmic Reticulum to Homo sapiens, Cardiomyocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Sodium/potassium-transporting ATPase subunit alpha-3
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-3

SubPathwayControl318
type: Interaction
name: SubPathway318Control
name: ActivatingSubPathwayControl
participant: G-protein signalling cascade
participant: Muscarinic acetylcholine receptor M2
participant: Acetylcholine-activated potassium channel (IKACh)

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

SubPathwayControl319
type: Interaction
name: SubPathway319Control
name: InhibitorySubPathwayControl
participant: Cardiac phospholamban inhibits Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
participant: Cardiac phospholamban
participant: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

Reference/UniProt Q9Y6J6
type: UnificationXref
id: Q9Y6J6
db: UniProt

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha
name: SubPathwayActivation
name: SubPathwayActivator

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: Protein
cellular location: Sarcoplasmic Reticulum
entity reference: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

Reference/UniProt O95180
type: UnificationXref
id: O95180
db: UniProt

Tropomyosin alpha-1 chain
type: Protein
cellular location: Cytoplasm
entity reference: Tropomyosin alpha-1 chain

Reference/UniProt Q13424
type: UnificationXref
id: Q13424
db: UniProt

Voltage-dependent T-type calcium channel subunit alpha-1H
type: ProteinReference
xref: Reference/UniProt O95180

Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
type: Protein
entity reference: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

Reference/UniProt Q13425
type: UnificationXref
id: Q13425
db: UniProt

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

G-protein signalling cascade
type: Pathway
name: ActivatingSubPathway

Cardiac phospholamban
type: Protein
cellular location: Sarcoplasmic Reticulum
entity reference: Cardiac phospholamban

Cardiac phospholamban inhibits Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: Pathway
name: InhibitorySubPathway

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Beta-1 adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P08588
organism: BiologicalState65

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644
organism: BiologicalState47

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Reference/UniProt P16615
type: UnificationXref
id: P16615
db: UniProt

Interaction2851
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Troponin activates Tropomyosin
participant: Calcium_Troponin
participant: Tropomyosin

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Protein/2706/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 1.0

Reference/UniProt Q9Y3Q4
type: UnificationXref
id: Q9Y3Q4
db: UniProt

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Potassium voltage-gated channel subfamily E member 1
type: ProteinReference
xref: Reference/UniProt P15382

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Kv channel-interacting protein 2
type: ProteinReference
xref: Reference/UniProt Q9NS61

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/UniProt P32418
type: UnificationXref
id: P32418
db: UniProt

Reference/UniProt Q09428
type: UnificationXref
id: Q09428
db: UniProt

Ryanodine receptor 2
type: Protein
entity reference: Ryanodine receptor 2

Reference/UniProt Q12959
type: UnificationXref
id: Q12959
db: UniProt

ATP-binding cassette sub-family C member 8
type: Protein
entity reference: ATP-binding cassette sub-family C member 8

G-protein signalling cascade
type: Pathway
name: ActivatingSubPathway

cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel
type: Pathway
name: ActivatingSubPathway

cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2
type: Pathway
name: ActivatingSubPathway

Potassium voltage-gated channel subfamily E member 2
type: ProteinReference
xref: Reference/UniProt Q9Y6J6

Calcium activates Ryanodine receptor 2
type: Pathway
name: ActivatingSubPathway

Reference/PathWhiz PW000365
type: UnificationXref
id: PW000365
db: PathWhiz

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: Reference/UniProt P48549

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: Protein
entity reference: ATPase, (Na+)/K+ transporting, beta 4 polypeptide

G protein-activated inward rectifier potassium channel 4
type: ProteinReference
xref: Reference/UniProt P48544

Inward rectifier potassium channel 4
type: ProteinReference
xref: Reference/UniProt P48050

Potassium voltage-gated channel subfamily D member 3
type: ProteinReference
xref: Reference/UniProt Q9UK17

Compound/PW C000414 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q12809
type: UnificationXref
id: Q12809
db: UniProt

Sodium channel protein type 5 subunit alpha
type: Protein
entity reference: Sodium channel protein type 5 subunit alpha

Reference/BRENDA TISSUE ONTOLOGY BTO 0000562
type: UnificationXref
id: BTO:0000562
db: BRENDA TISSUE ONTOLOGY

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C001034 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

BoundComplex/507 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Troponin
stoichiometric coefficient: 1.0

Protein/2026 Sarcoplasmic Reticulum/Stoichiometry/5.0
type: Stoichiometry
physical entity: Cardiac phospholamban
stoichiometric coefficient: 5.0

Reference/UniProt P50993
type: UnificationXref
id: P50993
db: UniProt

Tropomyosin beta chain
type: Protein
cellular location: Cytoplasm
entity reference: Tropomyosin beta chain

ChemicalStructure/PW C009320
type: ChemicalStructure
structure format: SMILES
structure data: CC(C)NCC(O)COC1=CC=CC=C1CC=C

Potassium channel subfamily K member 1
type: ProteinReference
xref: Reference/UniProt O00180

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Sodium/potassium-transporting ATPase subunit alpha-2
type: ProteinReference
xref: Reference/UniProt P50993

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Protein/1845 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit alpha-1C
stoichiometric coefficient: 1.0

Reference/UniProt P08588
type: UnificationXref
id: P08588
db: UniProt

TransportCatalysis89
type: Catalysis
controller: Potassium channel subfamily K member 1
controlled: Transport116
control type: ACTIVATION

TransportCatalysis88
type: Catalysis
controller: ATP-sensitive inward rectifier potassium channel (IKATP)
controlled: Transport116
control type: ACTIVATION

TransportCatalysis87
type: Catalysis
controller: Voltage-gated rapid delayed rectifying potassium channel (IKr)
controlled: Transport116
control type: ACTIVATION

ATP-sensitive inward rectifier potassium channel 8
type: ProteinReference
xref: Reference/UniProt Q15842

TransportCatalysis82
type: Catalysis
controller: Inward rectifier potassium channel (IK1)
controlled: Transport116
control type: ACTIVATION

Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
type: ProteinReference
xref: Reference/UniProt Q5I7T1

Beta-1-syntrophin
type: Protein
entity reference: Beta-1-syntrophin

3.6.3.8
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C001104 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Phosphate
right: Calcium
right: Adenosine diphosphate
spontaneous: false
EC number: 3.6.3.8
left: Adenosine triphosphate
left: Calcium
left: Water
name: Adenosine triphosphate + Calcium + Water → Adenosine diphosphate + Calcium + Phosphate
conversion direction: LEFT_TO_RIGHT

Tropomyosin beta chain
type: ProteinReference
xref: Reference/UniProt P07951
organism: BiologicalState50

TransportCatalysis86
type: Catalysis
controller: Voltage-gated slow delayed rectifying potassium channel (IK5)
controlled: Transport116
control type: ACTIVATION

Muscarinic acetylcholine receptor M2
type: Protein
cellular location: Cell Membrane
entity reference: Muscarinic acetylcholine receptor M2
name: SubPathwayActivator

TransportCatalysis85
type: Catalysis
controller: Voltage-gated ultra rapid delayed rectifying potassium channel
controlled: Transport116
control type: ACTIVATION

Reference/UniProt P17612
type: UnificationXref
id: P17612
db: UniProt

Sodium/potassium-transporting ATPase subunit gamma
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit gamma

TransportCatalysis84
type: Catalysis
controller: Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto)
controlled: Transport116
control type: ACTIVATION

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

Tropomyosin alpha-1 chain
type: ProteinReference
xref: Reference/UniProt P09493
organism: BiologicalState50

Reference/UniProt P26678
type: UnificationXref
id: P26678
db: UniProt

TransportCatalysis83
type: Catalysis
controller: Acetylcholine-activated potassium channel (IKACh)
controlled: Transport116
control type: ACTIVATION

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Compound/PW C000457 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0