Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Protein/5743 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein disulfide-isomerase A4
stoichiometric coefficient: 1.0

Reference/PubChem-compound 923
type: UnificationXref
id: 923
db: PubChem-compound

ReactionCoupledTransportCatalysis4
type: Catalysis
controller: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
controlled: 3.6.3.8
control type: ACTIVATION

Voltage-gated slow delayed rectifying potassium channel (IK5)
type: Complex
component: Potassium voltage-gated channel subfamily KQT member 1
component: Potassium voltage-gated channel subfamily E member 1

Voltage-gated ultra rapid delayed rectifying potassium channel
type: Complex
component: Disks large homolog 1
component: Potassium voltage-gated channel subfamily A member 5

Disks large homolog 1
type: Protein
entity reference: Disks large homolog 1

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto)
type: Complex
component: Kv channel-interacting protein 2
component: Potassium voltage-gated channel subfamily D member 3

ATP-binding cassette sub-family C member 9
type: Protein
entity reference: ATP-binding cassette sub-family C member 9

Sodium/potassium-transporting ATPase subunit beta-3
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-3

Acetylcholine-activated potassium channel (IKACh)
type: Complex
component: G protein-activated inward rectifier potassium channel 4
component: G protein-activated inward rectifier potassium channel 1
name: SubPathwayActivation

Inward rectifier potassium channel (IK1)
type: Complex
component: Inward rectifier potassium channel 2
component: Inward rectifier potassium channel 4

Potassium voltage-gated channel subfamily A member 5
type: Protein
entity reference: Potassium voltage-gated channel subfamily A member 5

Catechol O-methyltransferase
type: ProteinReference
xref: Reference/UniProt P21964
organism: BiologicalState10

direct_interaction
type: InteractionVocabulary

Sodium/calcium exchanger 1
type: Protein
entity reference: Sodium/calcium exchanger 1

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: Protein
entity reference: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
name: SubPathwayInhibition

Protein/5738 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: DnaJ homolog subfamily B member 11
stoichiometric coefficient: 1.0

Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Transport119
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
right: Sodium
spontaneous: false
left: Sodium
left: Calcium
name: Calcium (→), Sodium (←) Transport: Homo sapiens, Cardiomyocyte, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/UniProt O00180
type: UnificationXref
id: O00180
db: UniProt

Phenytoin
type: SmallMoleculeReference
xref: Reference/KEGG Compound C07443
xref: Reference/ChemSpider 1710
xref: Reference/ChEBI CHEBI 8107
xref: Reference/CAS 57-41-0
xref: Reference/PubChem-compound 1775
xref: Reference/HMDB HMDB0014397
chemical formula: C15H12N2O2
molecular weight: 252.08987
structure: ChemicalStructure/PW C008794

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Transport116
type: Transport
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Potassium
spontaneous: false
left: Potassium
name: Potassium (→) Transport: Homo sapiens, Cardiomyocyte, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reaction179579
type: BiochemicalReaction
participant stoichiometry: Protein/Generic536 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: BoundComplex/507 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
right: Calcium_Troponin
spontaneous: false
left: Troponin
left: Calcium
name: Calcium + Troponin → Calcium + Troponin
conversion direction: LEFT_TO_RIGHT

Transport120
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/1.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Voltage-gated T-type calcium channel (ICaT)
type: Complex
component: Voltage-dependent T-type calcium channel subunit alpha-1G
component: Voltage-dependent T-type calcium channel subunit alpha-1H

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADPH

Calcium
type: SmallMolecule
cellular location: Cytosol
entity reference: Calcium
name: SubPathwayActivator

Voltage-gated sodium channel (INa)
type: Complex
component: Sodium channel protein type 5 subunit alpha
component: Beta-1-syntrophin
component: Beta-2-syntrophin
component: Alpha-1-syntrophin

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Voltage-depenent L-type calcium channel
type: Complex
component stoichiometry: Protein/2720/Stoichiometry/1.0
component stoichiometry: Protein/1845/Stoichiometry/1.0
component stoichiometry: Protein/2706/Stoichiometry/1.0
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit beta-1
component: Voltage-dependent L-type calcium channel subunit alpha-1C

Reference/UniProt P63252
type: UnificationXref
id: P63252
db: UniProt

Voltage-depenent L-type calcium channel
type: Complex
component stoichiometry: Protein/1845 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2706 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/2720 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Voltage-dependent calcium channel subunit alpha-2/delta-2
component: Voltage-dependent L-type calcium channel subunit alpha-1C
component: Voltage-dependent L-type calcium channel subunit beta-1
name: SubPathwayActivation

ATP-sensitive inward rectifier potassium channel (IKATP)
type: Complex
component: ATP-sensitive inward rectifier potassium channel 8
component: ATP-binding cassette sub-family C member 8
component: ATP-sensitive inward rectifier potassium channel 11
component: ATP-binding cassette sub-family C member 9

Voltage-gated rapid delayed rectifying potassium channel (IKr)
type: Complex
component: Potassium voltage-gated channel subfamily E member 2
component: Potassium voltage-gated channel subfamily H member 2
component: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

Ryanodine receptor 2
type: ProteinReference
xref: Reference/UniProt Q92736

Reference/UniProt P21964
type: UnificationXref
id: P21964
db: UniProt

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

SubPathwayInteraction109962
type: Interaction
name: SubPathwayReaction
name: SubPathway109962Reaction
participant: Tropomyosin

Compound/PW C000457 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Compound/PW C001420 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/UniProt P05023
type: UnificationXref
id: P05023
db: UniProt

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Reference/UniProt P05026
type: UnificationXref
id: P05026
db: UniProt

Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Protein/1543 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: NAD(P)H dehydrogenase [quinone] 1
stoichiometric coefficient: 2.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/HMDB HMDB0014397
type: UnificationXref
id: HMDB0014397
db: HMDB

Reference/ChEBI CHEBI 17200
type: UnificationXref
id: CHEBI:17200
db: ChEBI

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Hydrogen Ion
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Hydrogen Ion

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Sodium channel protein type 5 subunit alpha
type: ProteinReference
xref: Reference/UniProt Q14524
organism: Homo sapiens

Sarcoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0016529

Reference/BRENDA TISSUE ONTOLOGY BTO 0000887
type: UnificationXref
id: BTO:0000887
db: BRENDA TISSUE ONTOLOGY

Reference/UniProt Q13936
type: UnificationXref
id: Q13936
db: UniProt

Adenosine diphosphate
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Adenosine diphosphate

Reference/UniProt P11712
type: UnificationXref
id: P11712
db: UniProt

Reference/BioCyc UDP-GLUCURONATE
type: UnificationXref
id: UDP-GLUCURONATE
db: BioCyc

Reference/PubChem-compound 6031
type: UnificationXref
id: 6031
db: PubChem-compound

Reference/PubChem-compound 813
type: UnificationXref
id: 813
db: PubChem-compound

Reference/UniProt Q6IN67
type: UnificationXref
id: Q6IN67
db: UniProt

Sodium/potassium ATPase
type: Complex
component: Sodium/potassium-transporting ATPase subunit beta-2
component: Sodium/potassium-transporting ATPase subunit alpha-1
component: ATPase, (Na+)/K+ transporting, beta 4 polypeptide
component: Sodium/potassium-transporting ATPase subunit beta-1
component: Sodium/potassium-transporting ATPase subunit gamma
component: Sodium/potassium-transporting ATPase subunit alpha-4
component: Sodium/potassium-transporting ATPase subunit alpha-2
component: Sodium/potassium-transporting ATPase subunit beta-3
component: Sodium/potassium-transporting ATPase subunit alpha-3

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Beta-1-syntrophin
type: Protein
cellular location: Cell Membrane
entity reference: Beta-1-syntrophin

Reference/CELL TYPE ONTOLOGY CL 0000746
type: UnificationXref
id: CL:0000746
db: CELL TYPE ONTOLOGY

Sodium/potassium-transporting ATPase subunit beta-2
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-2

Sodium/potassium-transporting ATPase subunit beta-1
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit beta-1

Reference/UniProt Q9HCN8
type: UnificationXref
id: Q9HCN8
db: UniProt

Compound/PW C040697 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenytoin arene-oxide
stoichiometric coefficient: 1.0

Phenytoin catechol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Phenytoin catechol

Voltage-gated sodium channel (INa)
type: Complex
cellular location: Cell Membrane
component: Alpha-1-syntrophin
component: Beta-2-syntrophin
component: Sodium channel protein type 5 subunit alpha
component: Beta-1-syntrophin
name: SubPathwayInhibition

Reference/UniProt P48050
type: UnificationXref
id: P48050
db: UniProt

Uridine diphosphate glucuronic acid
type: SmallMoleculeReference
xref: Reference/BioCyc UDP-GLUCURONATE
xref: Reference/CAS 2616-64-0
xref: Reference/PubChem-compound 17473
xref: Reference/HMDB HMDB0000935
xref: Reference/ChEBI CHEBI 17200
xref: Reference/ChemSpider 16522
xref: Reference/KEGG Compound C00167
chemical formula: C15H22N2O18P2
molecular weight: 580.0343
structure: ChemicalStructure/PW C000746

Reference/KEGG Compound C00238
type: UnificationXref
id: C00238
db: KEGG Compound

Reference/UniProt Q92736
type: UnificationXref
id: Q92736
db: UniProt

Reference/CAS 57-41-0
type: UnificationXref
id: 57-41-0
db: CAS

ReactionCatalysis2171
type: Catalysis
controller: Cytochrome P450 2C19
controlled: 1.14.14.1
control type: ACTIVATION

Protein/5744 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein disulfide-isomerase A6
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Protein/5739 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: HSP90B1 protein
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Water

Troponin
type: ProteinReference
organism: BiologicalState50

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

UDP-glucuronosyltransferase 1-9
type: ProteinReference
xref: Reference/UniProt O60656
organism: BiologicalState10

UDP-glucuronosyltransferase 1-1
type: ProteinReference
xref: Reference/UniProt P22309
organism: BiologicalState10

UDP-glucuronosyltransferase 1-4
type: ProteinReference
xref: Reference/UniProt P22310
organism: BiologicalState10

Beta-2-syntrophin
type: Protein
entity reference: Beta-2-syntrophin

Alpha-1-syntrophin
type: Protein
entity reference: Alpha-1-syntrophin

Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

ReactionCatalysis2173
type: Catalysis
controller: Cytochrome P450 2E1
controlled: 1.14.14.1
control type: ACTIVATION

ReactionCatalysis2175
type: Catalysis
controller: Epoxide hydrolase 1
controlled: 1.14.14.1
control type: ACTIVATION

ReactionCatalysis2178
type: Catalysis
controller: Cytochrome P450 2C19
controlled: Reaction2289
control type: ACTIVATION

ReactionCatalysis2177
type: Catalysis
controller: Cytochrome P450 2C9
controlled: Reaction2289
control type: ACTIVATION

Compound/PW C000749 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/UniProt Q13884
type: UnificationXref
id: Q13884
db: UniProt

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit
name: SubPathwayActivation

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

ReactionCatalysis2180
type: Catalysis
controller: Cytochrome P450 3A4
controlled: Reaction2289
control type: ACTIVATION

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

ReactionCatalysis2183
type: Catalysis
controller: UDP-glucuronosyltransferase 1-1
controlled: 5.3.4.1
control type: ACTIVATION

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/CAS 24203-36-9
type: UnificationXref
id: 24203-36-9
db: CAS

Sodium/potassium-transporting ATPase subunit alpha-4
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-4

Reference/KEGG Compound C01330
type: UnificationXref
id: C01330
db: KEGG Compound

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Transport53
type: Transport
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
participant stoichiometry: Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000457 Cytosol/Stoichiometry/2.0
right: Sodium
right: Potassium
spontaneous: false
left: Sodium
left: Potassium
name: Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

NADP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADP

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Cytochrome P450 1A2
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 1A2

Reference/CAS 2784-27-2
type: UnificationXref
id: 2784-27-2
db: CAS

Sodium/potassium-transporting ATPase subunit alpha-1
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-1

Transport62
type: Transport
participant stoichiometry: Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000458 Cytosol/Stoichiometry/1.0
right: Sodium
spontaneous: false
left: Sodium
name: Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
type: Protein
entity reference: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Cardiomyocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000746

UDP-glucuronosyltransferase 1-6
type: ProteinReference
xref: Reference/UniProt P19224
organism: BiologicalState10

Reference/ChemSpider 16756
type: UnificationXref
id: 16756
db: ChemSpider

ReactionCatalysis2185
type: Catalysis
controller: UDP-glucuronosyltransferase 1-6
controlled: 5.3.4.1
control type: ACTIVATION

ReactionCatalysis2184
type: Catalysis
controller: UDP-glucuronosyltransferase 1-4
controlled: 5.3.4.1
control type: ACTIVATION

ReactionCatalysis2187
type: Catalysis
controller: Catechol O-methyltransferase
controlled: 2.1.1.6
control type: ACTIVATION

ReactionCatalysis2186
type: Catalysis
controller: UDP-glucuronosyltransferase 1-9
controlled: 5.3.4.1
control type: ACTIVATION

ReactionCatalysis2188
type: Catalysis
controller: NAD(P)H dehydrogenase [quinone] 1
controlled: 1.6.5.2
control type: ACTIVATION

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Inward rectifier potassium channel 2
type: ProteinReference
xref: Reference/UniProt P63252

BiologicalState47
type: BioSource
cell type: Cardiomyocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Cardiomyocyte

Reference/UniProt P54710
type: UnificationXref
id: P54710
db: UniProt

Protein/2706 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 1.0

5.3.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040701 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040699 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Uridine 5'-diphosphate
right: 4-Hydroxyphenytoin glucuronide
spontaneous: false
EC number: 5.3.4.1
left: Uridine diphosphate glucuronic acid
left: Hydroxyphenytoin
name: Hydroxyphenytoin + Uridine diphosphate glucuronic acid → 4-Hydroxyphenytoin glucuronide + Uridine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

2.1.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040700 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040702 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000749 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Phenytoin methylcatechol
right: S-Adenosylhomocysteine
spontaneous: false
EC number: 2.1.1.6
left: S-Adenosylmethionine
left: Phenytoin catechol
name: Phenytoin catechol + S-Adenosylmethionine → Phenytoin methylcatechol + S-Adenosylhomocysteine
conversion direction: LEFT_TO_RIGHT

78 kDa glucose-regulated protein
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: 78 kDa glucose-regulated protein

Reference/KEGG Compound C00015
type: UnificationXref
id: C00015
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reaction2287
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040699 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040697 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Hydroxyphenytoin
spontaneous: false
left: Phenytoin arene-oxide
name: Phenytoin arene-oxide → Hydroxyphenytoin
conversion direction: LEFT_TO_RIGHT

Reaction2288
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040698 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040700 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Phenytoin catechol
spontaneous: false
left: Phenytoin dihydrodiol
name: Phenytoin dihydrodiol → Phenytoin catechol
conversion direction: LEFT_TO_RIGHT

Compound/PW C040700 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenytoin catechol
stoichiometric coefficient: 1.0

Reaction2285
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008794 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040697 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: Phenytoin arene-oxide
right: NADP
spontaneous: false
left: Oxygen
left: NADPH
left: Phenytoin
left: Hydrogen Ion
name: Hydrogen Ion + NADPH + Oxygen + Phenytoin → NADP + Phenytoin arene-oxide + Water
conversion direction: LEFT_TO_RIGHT

1.14.14.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040698 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040697 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Phenytoin dihydrodiol
spontaneous: false
EC number: 1.14.14.1
left: Water
left: Phenytoin arene-oxide
name: Phenytoin arene-oxide + Water → Phenytoin dihydrodiol
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Cytochrome P450 2E1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 2E1

ATP-sensitive inward rectifier potassium channel 11
type: Protein
entity reference: ATP-sensitive inward rectifier potassium channel 11

Reference/CAS 14127-61-8
type: UnificationXref
id: 14127-61-8
db: CAS

BiologicalState50
type: BioSource
cell type: Myocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Muscle, Myocyte
tissue: Muscle

Reference/UniProt Q9NS61
type: UnificationXref
id: Q9NS61
db: UniProt

Reaction2289
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040699 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040700 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: Phenytoin catechol
right: NADP
spontaneous: false
left: Oxygen
left: Hydroxyphenytoin
left: NADPH
left: Hydrogen Ion
name: Hydrogen Ion + Hydroxyphenytoin + NADPH + Oxygen → NADP + Phenytoin catechol + Water
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P15382
type: UnificationXref
id: P15382
db: UniProt

Reference/UniProt Q13733
type: UnificationXref
id: Q13733
db: UniProt

Reference/UniProt Q9UK17
type: UnificationXref
id: Q9UK17
db: UniProt

ChemicalStructure/PW C040697
type: ChemicalStructure
structure format: SMILES

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

Calcium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Calcium

ChemicalStructure/PW C040699
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040698
type: ChemicalStructure
structure format: SMILES

Compound/PW C000457 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Protein disulfide-isomerase A2
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Protein disulfide-isomerase A2

Sodium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Sodium

Adenosine triphosphate
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Adenosine triphosphate

Reference/ChEBI CHEBI 8107
type: UnificationXref
id: CHEBI:8107
db: ChEBI

Reference/ChEBI CHEBI 29108
type: UnificationXref
id: CHEBI:29108
db: ChEBI

Troponin
type: Protein
cellular location: Cytoplasm
entity reference: Troponin

HYOU1 protein
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: HYOU1 protein

Reference/ChEBI CHEBI 29101
type: UnificationXref
id: CHEBI:29101
db: ChEBI

Reference/ChEBI CHEBI 29103
type: UnificationXref
id: CHEBI:29103
db: ChEBI

UDP-glucuronosyltransferase 1-6
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: UDP-glucuronosyltransferase 1-6

Reference/PubChem-compound 1775
type: UnificationXref
id: 1775
db: PubChem-compound

Reference/ChemSpider 899
type: UnificationXref
id: 899
db: ChemSpider

Phenytoin methylcatechol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Phenytoin methylcatechol

Reference/UniProt P51787
type: UnificationXref
id: P51787
db: UniProt

Potassium
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Potassium

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/3195/Stoichiometry/4.0
component: Ryanodine receptor 2

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/UniProt P07951
type: UnificationXref
id: P07951
db: UniProt

Voltage-dependent L-type calcium channel subunit alpha-1C
type: ProteinReference
xref: Reference/UniProt Q13936

Reference/ChemSpider 119152
type: UnificationXref
id: 119152
db: ChemSpider

Potassium voltage-gated channel subfamily H member 2
type: ProteinReference
xref: Reference/UniProt Q12809

Reference/BioCyc K+
type: UnificationXref
id: K%2b
db: BioCyc

Reference/UniProt P54709
type: UnificationXref
id: P54709
db: UniProt

Reference/KEGG Compound C00167
type: UnificationXref
id: C00167
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

S-Adenosylmethionine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: S-Adenosylmethionine

Cardiac phospholamban
type: Complex
component stoichiometry: Protein/2026 Sarcoplasmic Reticulum/Stoichiometry/5.0
cellular location: Sarcoplasmic Reticulum
component: Cardiac phospholamban
name: SubPathwayInhibitor

1.6.5.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040700 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040703 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
right: Phenytoin quinone
right: NADPH
spontaneous: false
EC number: 1.6.5.2
left: Phenytoin catechol
left: NADP
name: NADP + Phenytoin catechol ↔ NADPH + Phenytoin quinone
conversion direction: REVERSIBLE

Uridine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17659
xref: Reference/PubChem-compound 6031
xref: Reference/CAS 58-98-0
xref: Reference/HMDB HMDB0000295
xref: Reference/KEGG Compound C00015
xref: Reference/ChemSpider 5809
xref: Reference/BioCyc UDP
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C000201

Reference/CAS 17341-25-2
type: UnificationXref
id: 17341-25-2
db: CAS

Potassium voltage-gated channel subfamily KQT member 1
type: ProteinReference
xref: Reference/UniProt P51787

Compound/PW C001104 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

SubPathwayControl320
type: Interaction
name: ActivatingSubPathwayControl
name: SubPathway320Control
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: cAMP-dependent protein kinase type I-alpha regulatory subunit
participant: G-protein signalling cascade
participant: Beta-1 adrenergic receptor

Epoxide hydrolase 1
type: ProteinReference
xref: Reference/UniProt P07099
organism: BiologicalState10

SubPathwayControl321
type: Interaction
name: SubPathway321Control
name: ActivatingSubPathwayControl
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel
participant: Voltage-depenent L-type calcium channel

SubPathwayControl322
type: Interaction
name: ActivatingSubPathwayControl
name: SubPathway322Control
participant: cAMP-dependent protein kinase catalytic subunit alpha
participant: Ryanodine receptor 2
participant: cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2

Potassium
type: SmallMolecule
cellular location: Cytosol
entity reference: Potassium

SubPathwayControl325
type: Interaction
name: SubPathway325Control
name: ActivatingSubPathwayControl
participant: Ryanodine receptor 2
participant: Calcium
participant: Calcium activates Ryanodine receptor 2

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

4-Hydroxyphenytoin glucuronide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: 4-Hydroxyphenytoin glucuronide

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

Hydroxyphenytoin
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Hydroxyphenytoin

Reference/ChemSpider 791
type: UnificationXref
id: 791
db: ChemSpider

Reference/HMDB HMDB0060769
type: UnificationXref
id: HMDB0060769
db: HMDB

Tropomyosin
type: Complex
component stoichiometry: Protein/3291 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/3290 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Tropomyosin alpha-1 chain
component: Tropomyosin beta chain
name: SubPathwayInput

Reference/ChemSpider 16522
type: UnificationXref
id: 16522
db: ChemSpider

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: ProteinReference
xref: Reference/UniProt Q9NY47

Voltage-dependent T-type calcium channel subunit alpha-1G
type: ProteinReference
xref: Reference/UniProt O43497

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

BiologicalState10
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver
tissue: Liver

SubPathwayControl318
type: Interaction
name: SubPathway318Control
name: ActivatingSubPathwayControl
participant: G-protein signalling cascade
participant: Muscarinic acetylcholine receptor M2
participant: Acetylcholine-activated potassium channel (IKACh)

SubPathwayControl319
type: Interaction
name: SubPathway319Control
name: InhibitorySubPathwayControl
participant: Cardiac phospholamban inhibits Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
participant: Cardiac phospholamban
participant: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Compound/PW C000746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate glucuronic acid
stoichiometric coefficient: 1.0

Reference/UniProt O95180
type: UnificationXref
id: O95180
db: UniProt

Tropomyosin alpha-1 chain
type: Protein
cellular location: Cytoplasm
entity reference: Tropomyosin alpha-1 chain

Voltage-dependent T-type calcium channel subunit alpha-1H
type: ProteinReference
xref: Reference/UniProt O95180

Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
type: Protein
entity reference: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

SubPathwayControl582
type: Interaction
name: InhibitorySubPathwayControl
name: SubPathway582Control
participant: Phenytoin
participant: Drug inhibition of Sodium channel protein type 5 subunit alpha
participant: Voltage-gated sodium channel (INa)

G-protein signalling cascade
type: Pathway
name: ActivatingSubPathway

Cardiac phospholamban
type: Protein
cellular location: Sarcoplasmic Reticulum
entity reference: Cardiac phospholamban

Cardiac phospholamban inhibits Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: Pathway
name: InhibitorySubPathway

ChemicalStructure/PW C040701
type: ChemicalStructure
structure format: SMILES

Phenytoin dihydrodiol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Phenytoin dihydrodiol

ChemicalStructure/PW C040700
type: ChemicalStructure
structure format: SMILES

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: Reference/UniProt Q02641

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Beta-1 adrenergic receptor
type: ProteinReference
xref: Reference/UniProt P08588
organism: BiologicalState47

Compound/PW C008794 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenytoin
stoichiometric coefficient: 1.0

Reference/CAS 58-98-0
type: UnificationXref
id: 58-98-0
db: CAS

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: Reference/UniProt P10644
organism: BiologicalState47

ChemicalStructure/PW C040703
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00076
type: UnificationXref
id: C00076
db: KEGG Compound

Reference/UniProt P16615
type: UnificationXref
id: P16615
db: UniProt

ChemicalStructure/PW C040702
type: ChemicalStructure
structure format: SMILES

Sodium
type: SmallMolecule
cellular location: Cytosol
entity reference: Sodium

Phenytoin
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Phenytoin

Compound/PW C040034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Protein/2720/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Calcium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000464
xref: Reference/BioCyc CA+2
xref: Reference/ChemSpider 266
xref: Reference/ChEBI CHEBI 29108
xref: Reference/CAS 14127-61-8
xref: Reference/KEGG Compound C00076
xref: Reference/PubChem-compound 271
chemical formula: Ca
molecular weight: 39.96259
structure: ChemicalStructure/PW C000353

Protein/2706/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent calcium channel subunit alpha-2/delta-2
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0000295
type: UnificationXref
id: HMDB0000295
db: HMDB

Reference/UniProt Q9Y3Q4
type: UnificationXref
id: Q9Y3Q4
db: UniProt

Reference/ChemSpider 5809
type: UnificationXref
id: 5809
db: ChemSpider

Potassium voltage-gated channel subfamily E member 1
type: ProteinReference
xref: Reference/UniProt P15382

Protein/465 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-glucuronosyltransferase 1-1
stoichiometric coefficient: 1.0

NAD(P)H dehydrogenase [quinone] 1
type: Complex
component stoichiometry: Protein/1543 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: NAD(P)H dehydrogenase [quinone] 1

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Kv channel-interacting protein 2
type: ProteinReference
xref: Reference/UniProt Q9NS61

Reference/ChemSpider 134809
type: UnificationXref
id: 134809
db: ChemSpider

Reference/UniProt Q09428
type: UnificationXref
id: Q09428
db: UniProt

Ryanodine receptor 2
type: Protein
entity reference: Ryanodine receptor 2

Reference/UniProt Q12959
type: UnificationXref
id: Q12959
db: UniProt

Compound/PW C040698 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenytoin dihydrodiol
stoichiometric coefficient: 1.0

G-protein signalling cascade
type: Pathway
name: ActivatingSubPathway

cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel
type: Pathway
name: ActivatingSubPathway

cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2
type: Pathway
name: ActivatingSubPathway

Reference/HMDB HMDB0060598
type: UnificationXref
id: HMDB0060598
db: HMDB

Potassium voltage-gated channel subfamily E member 2
type: ProteinReference
xref: Reference/UniProt Q9Y6J6

Calcium activates Ryanodine receptor 2
type: Pathway
name: ActivatingSubPathway

G protein-activated inward rectifier potassium channel 1
type: ProteinReference
xref: Reference/UniProt P48549

Phenytoin
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phenytoin
name: SubPathwayInhibitor

G protein-activated inward rectifier potassium channel 4
type: ProteinReference
xref: Reference/UniProt P48544

Inward rectifier potassium channel 4
type: ProteinReference
xref: Reference/UniProt P48050

Potassium voltage-gated channel subfamily D member 3
type: ProteinReference
xref: Reference/UniProt Q9UK17

Compound/PW C000414 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Reference/UniProt Q12809
type: UnificationXref
id: Q12809
db: UniProt

Sodium channel protein type 5 subunit alpha
type: Protein
entity reference: Sodium channel protein type 5 subunit alpha

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C001034 Sarcoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

BoundComplex/507 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium_Troponin
stoichiometric coefficient: 1.0

Protein/2026 Sarcoplasmic Reticulum/Stoichiometry/5.0
type: Stoichiometry
physical entity: Cardiac phospholamban
stoichiometric coefficient: 5.0

Reference/UniProt P50993
type: UnificationXref
id: P50993
db: UniProt

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Uridine 5'-diphosphate

Tropomyosin beta chain
type: Protein
cellular location: Cytoplasm
entity reference: Tropomyosin beta chain

Potassium channel subfamily K member 1
type: ProteinReference
xref: Reference/UniProt O00180

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

NAD(P)H dehydrogenase [quinone] 1
type: ProteinReference
xref: Reference/UniProt P15559
organism: BiologicalState10

Sodium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000588
xref: Reference/PubChem-compound 923
xref: Reference/KEGG Compound C01330
xref: Reference/ChEBI CHEBI 29101
xref: Reference/ChemSpider 899
xref: Reference/CAS 17341-25-2
chemical formula: Na
molecular weight: 22.989769
structure: ChemicalStructure/PW C000458

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Sodium/potassium-transporting ATPase subunit alpha-2
type: ProteinReference
xref: Reference/UniProt P50993

Potassium
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00238
xref: Reference/HMDB HMDB0000586
xref: Reference/PubChem-compound 813
xref: Reference/ChemSpider 791
xref: Reference/CAS 24203-36-9
xref: Reference/BioCyc K+
xref: Reference/ChEBI CHEBI 29103
chemical formula: K
molecular weight: 38.963707
structure: ChemicalStructure/PW C000457

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Compound/PW C040699 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydroxyphenytoin
stoichiometric coefficient: 1.0

Reference/UniProt P15559
type: UnificationXref
id: P15559
db: UniProt

Reference/UniProt Q15084
type: UnificationXref
id: Q15084
db: UniProt

ATP-sensitive inward rectifier potassium channel 8
type: ProteinReference
xref: Reference/UniProt Q15842

Reference/UniProt P23284
type: UnificationXref
id: P23284
db: UniProt

Reference/PubChem-compound 169703
type: UnificationXref
id: 169703
db: PubChem-compound

3.6.3.8
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C001104 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Sarcoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Phosphate
right: Calcium
right: Adenosine diphosphate
spontaneous: false
EC number: 3.6.3.8
left: Adenosine triphosphate
left: Calcium
left: Water
name: Adenosine triphosphate + Calcium + Water → Adenosine diphosphate + Calcium + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P17612
type: UnificationXref
id: P17612
db: UniProt

Reference/UniProt P26678
type: UnificationXref
id: P26678
db: UniProt

Drug inhibition of Sodium channel protein type 5 subunit alpha
type: Pathway
name: InhibitorySubPathway

Catechol O-methyltransferase
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Catechol O-methyltransferase

Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Compound/PW C000457 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

Sodium/potassium-transporting ATPase subunit alpha-3
type: ProteinReference
xref: Reference/UniProt P13637

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Cytochrome P450 2E1
type: ProteinReference
xref: Reference/UniProt P05181
organism: BiologicalState10

Reference/UniProt P13667
type: UnificationXref
id: P13667
db: UniProt

TransportCatalysis93
type: Catalysis
controller: Voltage-gated T-type calcium channel (ICaT)
controlled: Transport35
control type: ACTIVATION

TransportCatalysis92
type: Catalysis
controller: Voltage-gated sodium channel (INa)
controlled: Transport62
control type: ACTIVATION

TransportCatalysis91
type: Catalysis
controller: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
controlled: Transport120
control type: ACTIVATION

TransportCatalysis90
type: Catalysis
controller: Sodium/calcium exchanger 1
controlled: Transport119
control type: ACTIVATION

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Cytochrome P450 3A4
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 3A4

Cytochrome P450 1A2
type: ProteinReference
xref: Reference/UniProt P05177
organism: BiologicalState10

Stromal cell-derived factor 2-like protein 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Stromal cell-derived factor 2-like protein 1

Compound/PW C040701 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4-Hydroxyphenytoin glucuronide
stoichiometric coefficient: 1.0

TransportCatalysis9
type: Catalysis
controller: Voltage-depenent L-type calcium channel
controlled: Transport35
control type: ACTIVATION

Reference/CAS 2616-64-0
type: UnificationXref
id: 2616-64-0
db: CAS

Cytochrome P450 3A4
type: ProteinReference
xref: Reference/UniProt P08684
organism: BiologicalState10

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

ChemicalStructure/PW C000458
type: ChemicalStructure
structure format: SMILES
structure data: [Na+]

ChemicalStructure/PW C000457
type: ChemicalStructure
structure format: SMILES
structure data: [K+]

Reference/UniProt P48544
type: UnificationXref
id: P48544
db: UniProt

Inward rectifier potassium channel 2
type: Protein
entity reference: Inward rectifier potassium channel 2

Reference/UniProt P48549
type: UnificationXref
id: P48549
db: UniProt

Uridine diphosphate glucuronic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Uridine diphosphate glucuronic acid

Phenytoin arene-oxide
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Phenytoin arene-oxide

Reference/UniProt Q5I7T1
type: UnificationXref
id: Q5I7T1
db: UniProt

Reference/ChEBI CHEBI 63804
type: UnificationXref
id: CHEBI:63804
db: ChEBI

Ryanodine receptor 2
type: Protein
cellular location: Sarcoplasmic Reticulum
entity reference: Ryanodine receptor 2

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/UniProt P33261
type: UnificationXref
id: P33261
db: UniProt

Reference/GENE ONTOLOGY GO 0016529
type: UnificationXref
id: GO:0016529
db: GENE ONTOLOGY

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Phenytoin quinone
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phenytoin quinone

Reference/CELL TYPE ONTOLOGY CL 0000187
type: UnificationXref
id: CL:0000187
db: CELL TYPE ONTOLOGY

Reference/UniProt O60706
type: UnificationXref
id: O60706
db: UniProt

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/UniProt P14415
type: UnificationXref
id: P14415
db: UniProt

ATP-binding cassette sub-family C member 8
type: ProteinReference
xref: Reference/UniProt Q09428

Endoplasmic reticulum resident protein 29
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Endoplasmic reticulum resident protein 29

Calcium_Troponin
type: Complex
component stoichiometry: Protein/Generic536 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Compound/PW C000353 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Troponin
component: Calcium

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Protein/2720 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit beta-1
stoichiometric coefficient: 1.0

Protein/3291 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tropomyosin beta chain
stoichiometric coefficient: 1.0

Reference/UniProt P11021
type: UnificationXref
id: P11021
db: UniProt

Reference/UniProt O43497
type: UnificationXref
id: O43497
db: UniProt

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: ProteinReference
xref: Reference/UniProt B7ZKV8

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Compound/PW C040700 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenytoin catechol
stoichiometric coefficient: 1.0

Cytochrome P450 2C9
type: ProteinReference
xref: Reference/UniProt P11712
organism: BiologicalState10

Cytochrome P450 2C19
type: ProteinReference
xref: Reference/UniProt P33261
organism: BiologicalState10

Reference/ChemSpider 266
type: UnificationXref
id: 266
db: ChemSpider

ChemicalStructure/PW C000201
type: ChemicalStructure
structure format: SMILES

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Protein/3195/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
cellular location: Cell Membrane
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

Phosphate
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Phosphate

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Sodium/potassium-transporting ATPase subunit gamma
type: ProteinReference
xref: Reference/UniProt P54710

Reference/UniProt P22460
type: UnificationXref
id: P22460
db: UniProt

Potassium voltage-gated channel subfamily H member 2
type: Protein
entity reference: Potassium voltage-gated channel subfamily H member 2

Protein/3290 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tropomyosin alpha-1 chain
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Beta-1-syntrophin
type: ProteinReference
xref: Reference/UniProt Q13884
organism: Homo sapiens

Muscle Contraction
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109962
pathway component: SubPathwayInteraction109962
name: SubPathway

Voltage-dependent L-type calcium channel subunit alpha-1C
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C

Sodium channel protein type 5 subunit alpha
type: Protein
cellular location: Cell Membrane
entity reference: Sodium channel protein type 5 subunit alpha

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0060866
type: UnificationXref
id: HMDB0060866
db: HMDB

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/HMDB HMDB0060865
type: UnificationXref
id: HMDB0060865
db: HMDB

Reference/HMDB HMDB0060868
type: UnificationXref
id: HMDB0060868
db: HMDB

Reference/HMDB HMDB0060867
type: UnificationXref
id: HMDB0060867
db: HMDB

Reference/HMDB HMDB0060864
type: UnificationXref
id: HMDB0060864
db: HMDB

Reference/UniProt Q96GW1
type: UnificationXref
id: Q96GW1
db: UniProt

Protein/5746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Endoplasmic reticulum resident protein 29
stoichiometric coefficient: 1.0

Reference/ChemSpider 1710
type: UnificationXref
id: 1710
db: ChemSpider

Voltage-dependent calcium channel subunit alpha-2/delta-2
type: Protein
entity reference: Voltage-dependent calcium channel subunit alpha-2/delta-2

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxygen

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

ATP-binding cassette sub-family C member 9
type: ProteinReference
xref: Reference/UniProt O60706

Sodium/potassium-transporting ATPase subunit beta-3
type: ProteinReference
xref: Reference/UniProt P54709

Potassium voltage-gated channel subfamily A member 5
type: ProteinReference
xref: Reference/UniProt P22460

Reference/UniProt Q13087
type: UnificationXref
id: Q13087
db: UniProt

Disks large homolog 1
type: ProteinReference
xref: Reference/UniProt Q12959

Compound/PW C000458 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/UniProt Q9UBS4
type: UnificationXref
id: Q9UBS4
db: UniProt

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: ProteinReference
xref: Reference/UniProt P16615
organism: BiologicalState47

Sodium/calcium exchanger 1
type: ProteinReference
xref: Reference/UniProt P32418

Potassium voltage-gated channel subfamily KQT member 1
type: Protein
entity reference: Potassium voltage-gated channel subfamily KQT member 1

Reference/UniProt P13637
type: UnificationXref
id: P13637
db: UniProt

Reference/UniProt Q9NY47
type: UnificationXref
id: Q9NY47
db: UniProt

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Reference/UniProt P09493
type: UnificationXref
id: P09493
db: UniProt

Reference/KEGG Compound C07443
type: UnificationXref
id: C07443
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000464
type: UnificationXref
id: HMDB0000464
db: HMDB

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Protein disulfide-isomerase A6
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Protein disulfide-isomerase A6

Myocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000187

Reference/HMDB HMDB0000586
type: UnificationXref
id: HMDB0000586
db: HMDB

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000588
type: UnificationXref
id: HMDB0000588
db: HMDB

Reference/PubChem-compound 17473
type: UnificationXref
id: 17473
db: PubChem-compound

Muscle
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000887

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Voltage-dependent T-type calcium channel subunit alpha-1G
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1G

Voltage-dependent T-type calcium channel subunit alpha-1H
type: Protein
entity reference: Voltage-dependent T-type calcium channel subunit alpha-1H

DnaJ homolog subfamily B member 11
type: ProteinReference
xref: Reference/UniProt Q9UBS4
organism: BiologicalState10

Protein disulfide-isomerase A4
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Protein disulfide-isomerase A4

HSP90B1 protein
type: ProteinReference
xref: Reference/UniProt Q96GW1
organism: BiologicalState10

Muscarinic acetylcholine receptor M2
type: ProteinReference
xref: Reference/UniProt P08172
organism: BiologicalState47

Phenytoin catechol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 169703
xref: Reference/HMDB HMDB0060865
xref: Reference/ChemSpider 148411
chemical formula: C15H12N2O4
molecular weight: 284.0797
structure: ChemicalStructure/PW C040700

4-Hydroxyphenytoin glucuronide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 135250
xref: Reference/ChemSpider 119152
xref: Reference/HMDB HMDB0060769
chemical formula: C21H20N2O9
molecular weight: 444.11688
structure: ChemicalStructure/PW C040701

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

Phenytoin methylcatechol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0060867
chemical formula: C16H12N2O4
molecular weight: 296.0797
structure: ChemicalStructure/PW C040702

Phenytoin quinone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0060868
chemical formula: C15H10N2O4
molecular weight: 282.06406
structure: ChemicalStructure/PW C040703

Reference/UniProt P08172
type: UnificationXref
id: P08172
db: UniProt

ChemicalStructure/PW C000353
type: ChemicalStructure
structure format: SMILES
structure data: [Ca++]

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

UDP-glucuronosyltransferase 1-1
type: Complex
component stoichiometry: Protein/5742 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
component stoichiometry: Protein/465 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
component stoichiometry: Protein/5740 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
component stoichiometry: Protein/5743 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
component stoichiometry: Protein/4776 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
component stoichiometry: Protein/5745 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
component stoichiometry: Protein/5738 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
component stoichiometry: Protein/5741 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
component stoichiometry: Protein/5744 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
component stoichiometry: Protein/5739 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
component stoichiometry: Protein/5746 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
cellular location: Endoplasmic Reticulum Membrane
component: Stromal cell-derived factor 2-like protein 1
component: Protein disulfide-isomerase A6
component: HSP90B1 protein
component: Protein disulfide-isomerase A4
component: DnaJ homolog subfamily B member 11
component: UDP-glucuronosyltransferase 1-1
component: 78 kDa glucose-regulated protein
component: HYOU1 protein
component: Protein disulfide-isomerase A2
component: Peptidyl-prolyl cis-trans isomerase B
component: Endoplasmic reticulum resident protein 29

Stromal cell-derived factor 2-like protein 1
type: ProteinReference
xref: Reference/UniProt Q9HCN8
organism: BiologicalState10

Endoplasmic reticulum resident protein 29
type: ProteinReference
xref: Reference/UniProt P30040
organism: BiologicalState10

Protein disulfide-isomerase A4
type: ProteinReference
xref: Reference/UniProt P13667
organism: BiologicalState10

Protein disulfide-isomerase A6
type: ProteinReference
xref: Reference/UniProt Q15084
organism: BiologicalState10

Peptidyl-prolyl cis-trans isomerase B
type: ProteinReference
xref: Reference/UniProt P23284
organism: BiologicalState10

Voltage-dependent L-type calcium channel subunit beta-1
type: Protein
entity reference: Voltage-dependent L-type calcium channel subunit beta-1

HYOU1 protein
type: ProteinReference
xref: Reference/UniProt Q6IN67
organism: BiologicalState10

Reference/UniProt P07099
type: UnificationXref
id: P07099
db: UniProt

Protein disulfide-isomerase A2
type: ProteinReference
xref: Reference/UniProt Q13087
organism: BiologicalState10

78 kDa glucose-regulated protein
type: ProteinReference
xref: Reference/UniProt P11021
organism: BiologicalState10

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: Reference/UniProt P17612
organism: BiologicalState47

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Compound/PW C000458 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Potassium voltage-gated channel subfamily E member 2
type: Protein
entity reference: Potassium voltage-gated channel subfamily E member 2

DnaJ homolog subfamily B member 11
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: DnaJ homolog subfamily B member 11

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Sodium/potassium-transporting ATPase subunit beta-1
type: ProteinReference
xref: Reference/UniProt P05026

Kv channel-interacting protein 2
type: Protein
entity reference: Kv channel-interacting protein 2

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

TransportCatalysis10
type: Catalysis
controller: Ryanodine receptor 2
controlled: Transport36
control type: ACTIVATION

Sodium/potassium-transporting ATPase subunit beta-2
type: ProteinReference
xref: Reference/UniProt P14415

Reference/UniProt B7ZKV8
type: UnificationXref
id: B7ZKV8
db: UniProt

Potassium voltage-gated channel subfamily E member 1
type: Protein
entity reference: Potassium voltage-gated channel subfamily E member 1

Reference/BioCyc UDP
type: UnificationXref
id: UDP
db: BioCyc

Reference/UniProt O60656
type: UnificationXref
id: O60656
db: UniProt

Protein/5745 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Stromal cell-derived factor 2-like protein 1
stoichiometric coefficient: 1.0

Calcium
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Calcium

Reference/UniProt Q14524
type: UnificationXref
id: Q14524
db: UniProt

Reference/UniProt P30040
type: UnificationXref
id: P30040
db: UniProt

Reference/UniProt P22309
type: UnificationXref
id: P22309
db: UniProt

Potassium channel subfamily K member 1
type: Protein
entity reference: Potassium channel subfamily K member 1

G protein-activated inward rectifier potassium channel 4
type: Protein
entity reference: G protein-activated inward rectifier potassium channel 4

UDP-glucuronosyltransferase 1-4
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: UDP-glucuronosyltransferase 1-4

Reference/UniProt Q14654
type: UnificationXref
id: Q14654
db: UniProt

Phenytoin arene-oxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0060864
chemical formula: C15H12N2O3
molecular weight: 268.08478
structure: ChemicalStructure/PW C040697

Phenytoin dihydrodiol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 152954
xref: Reference/HMDB HMDB0060866
xref: Reference/ChemSpider 134809
chemical formula: C15H14N2O4
molecular weight: 286.09537
structure: ChemicalStructure/PW C040698

Compound/PW C000458 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 3.0

Compound/PW C000353 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Calcium
stoichiometric coefficient: 1.0

Hydroxyphenytoin
type: SmallMoleculeReference
xref: Reference/CAS 2784-27-2
xref: Reference/ChEBI CHEBI 63804
xref: Reference/ChemSpider 16756
xref: Reference/HMDB HMDB0060598
xref: Reference/PubChem-compound 17732
chemical formula: C15H12N2O3
molecular weight: 268.08478
structure: ChemicalStructure/PW C040699

Compound/PW C000457 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Potassium
stoichiometric coefficient: 2.0

Protein/1845/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit alpha-1C
stoichiometric coefficient: 1.0

Beta-2-syntrophin
type: ProteinReference
xref: Reference/UniProt Q13425
organism: Homo sapiens

TransportCatalysis23
type: Catalysis
controller: Sodium/potassium ATPase
controlled: Transport53
control type: ACTIVATION

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/HMDB HMDB0000935
type: UnificationXref
id: HMDB0000935
db: HMDB

Potassium voltage-gated channel subfamily D member 3
type: Protein
entity reference: Potassium voltage-gated channel subfamily D member 3

NAD(P)H dehydrogenase [quinone] 1
type: Protein
cellular location: Cytoplasm
entity reference: NAD(P)H dehydrogenase [quinone] 1

Alpha-1-syntrophin
type: ProteinReference
xref: Reference/UniProt Q13424
organism: Homo sapiens

Inward rectifier potassium channel 4
type: Protein
entity reference: Inward rectifier potassium channel 4

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

G protein-activated inward rectifier potassium channel 1
type: Protein
entity reference: G protein-activated inward rectifier potassium channel 1

Reference/UniProt Q02641
type: UnificationXref
id: Q02641
db: UniProt

Phenytoin (Antiarrhythmic) Action Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/3370
pathway order: PathwayEnzymeReaction/3375
pathway order: PathwaySubPathway/319
pathway order: PathwayEnzymeReaction/3376
pathway order: PathwayEnzymeReaction/3377
pathway order: PathwayEnzymeReaction/3378
pathway order: PathwaySubPathway/318
pathway order: PathwayEnzymeReaction/3371
pathway order: PathwayEnzymeReaction/3372
pathway order: PathwaySubPathway/109962
pathway order: PathwayEnzymeReaction/3373
pathway order: PathwayEnzymeReaction/3374
pathway order: PathwayTransport/1653
pathway order: PathwayTransport/1630
pathway order: PathwayTransport/1652
pathway order: PathwayTransport/1655
pathway order: PathwayEnzymeReaction/3368
pathway order: PathwayEnzymeReaction/3369
pathway order: PathwayTransport/1656
pathway order: PathwayInteraction/2851
pathway order: PathwaySubPathway/322
pathway order: PathwayEnzymeReaction/3380
pathway order: PathwaySubPathway/320
pathway order: PathwayEnzymeReaction/3381
pathway order: PathwaySubPathway/321
pathway order: PathwaySubPathway/582
pathway order: PathwayEnzymeReaction/3366
pathway order: PathwayEnzymeReaction/3367
pathway order: PathwayEnzymeReaction/3382
pathway order: PathwayTransport/1660
pathway order: PathwayTransport/1662
pathway order: PathwayTransport/1661
pathway order: PathwaySubPathway/325
pathway order: PathwayTransport/1664
pathway order: PathwayEnzymeReaction/2123351
pathway order: PathwayTransport/1665
pathway order: PathwayEnzymeReaction/3379
pathway order: PathwayTransport/1646
pathway order: PathwayTransport/1645
pathway order: PathwayTransport/1667
pathway order: PathwayTransport/1648
pathway order: PathwayTransport/1649
pathway order: PathwayEnzymeReaction/211631
pathway component: SubPathwayControl582
pathway component: ReactionCoupledTransportCatalysis4
pathway component: ReactionCatalysis2171
pathway component: Interaction2851
pathway component: TransportCatalysis10
pathway component: Muscle Contraction
pathway component: TransportCatalysis93
pathway component: TransportCatalysis92
pathway component: TransportCatalysis91
pathway component: TransportCatalysis90
pathway component: ReactionCatalysis2173
pathway component: ReactionCatalysis2175
pathway component: Transport119
pathway component: ReactionCatalysis2178
pathway component: ReactionCatalysis2177
pathway component: Transport116
pathway component: Reaction179579
pathway component: Transport120
pathway component: TransportCatalysis9
pathway component: ReactionCatalysis2180
pathway component: ReactionCatalysis2183
pathway component: TransportCatalysis23
pathway component: Transport53
pathway component: Transport62
pathway component: 1.6.5.2
pathway component: ReactionCatalysis2185
pathway component: ReactionCatalysis2184
pathway component: ReactionCatalysis2187
pathway component: ReactionCatalysis2186
pathway component: ReactionCatalysis2188
pathway component: SubPathwayControl320
pathway component: SubPathwayControl321
pathway component: SubPathwayControl322
pathway component: 5.3.4.1
pathway component: 2.1.1.6
pathway component: SubPathwayControl325

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

NADPH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADPH

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Sodium/potassium-transporting ATPase subunit alpha-4
type: ProteinReference
xref: Reference/UniProt Q13733

Protein/Generic536 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Troponin
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Sodium/potassium-transporting ATPase subunit alpha-2
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-2

Cardiac phospholamban
type: ProteinReference
xref: Reference/UniProt P26678
organism: BiologicalState47

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
type: ProteinReference
xref: Reference/UniProt Q9Y3Q4

Sodium/potassium-transporting ATPase subunit alpha-1
type: ProteinReference
xref: Reference/UniProt P05023

Cytochrome P450 2C9
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 2C9

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

HSP90B1 protein
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: HSP90B1 protein

Protein/3195 Sarcoplasmic Reticulum/Stoichiometry/4.0
type: Stoichiometry
physical entity: Ryanodine receptor 2
stoichiometric coefficient: 4.0

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

ATP-sensitive inward rectifier potassium channel 8
type: Protein
entity reference: ATP-sensitive inward rectifier potassium channel 8

Phenytoin catechol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phenytoin catechol

ChemicalStructure/PW C008794
type: ChemicalStructure
structure format: SMILES
structure data: O=C1NC(=O)C(N1)(C1=CC=CC=C1)C1=CC=CC=C1

Beta-1 adrenergic receptor
type: Protein
cellular location: Cell Membrane
entity reference: Beta-1 adrenergic receptor
name: SubPathwayActivator

Reference/UniProt Q15842
type: UnificationXref
id: Q15842
db: UniProt

Compound/PW C040703 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenytoin quinone
stoichiometric coefficient: 1.0

Transport35
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Extracellular Space/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Ryanodine receptor 2
type: Complex
component stoichiometry: Protein/3195 Sarcoplasmic Reticulum/Stoichiometry/4.0
cellular location: Sarcoplasmic Reticulum
component: Ryanodine receptor 2
name: SubPathwayActivation

ATP-sensitive inward rectifier potassium channel 11
type: ProteinReference
xref: Reference/UniProt Q14654

Transport36
type: Transport
participant stoichiometry: Compound/PW C000353 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000353 Sarcoplasmic Reticulum/Stoichiometry/1.0
right: Calcium
spontaneous: false
left: Calcium
name: Calcium (?) Transport: Homo sapiens, Cardiomyocyte, Sarcoplasmic Reticulum to Homo sapiens, Cardiomyocyte, Cytosol
conversion direction: LEFT_TO_RIGHT

Sodium/potassium-transporting ATPase subunit alpha-3
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit alpha-3

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Reference/UniProt Q9Y6J6
type: UnificationXref
id: Q9Y6J6
db: UniProt

cAMP-dependent protein kinase catalytic subunit alpha
type: Protein
cellular location: Cytosol
entity reference: cAMP-dependent protein kinase catalytic subunit alpha
name: SubPathwayActivation
name: SubPathwayActivator

Cytochrome P450 2C19
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 2C19

Reference/UniProt P22310
type: UnificationXref
id: P22310
db: UniProt

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
type: Protein
cellular location: Sarcoplasmic Reticulum
entity reference: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

ReactionCatalysis2165
type: Catalysis
controller: Cytochrome P450 2C9
controlled: Reaction2285
control type: ACTIVATION

ReactionCatalysis2167
type: Catalysis
controller: Cytochrome P450 1A2
controlled: 1.14.14.1
control type: ACTIVATION

Reference/UniProt Q13424
type: UnificationXref
id: Q13424
db: UniProt

ReactionCatalysis2166
type: Catalysis
controller: Cytochrome P450 2C19
controlled: Reaction2285
control type: ACTIVATION

UDP-glucuronosyltransferase 1-9
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: UDP-glucuronosyltransferase 1-9

Reference/UniProt Q13425
type: UnificationXref
id: Q13425
db: UniProt

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/SMPDB SMP0000327
type: UnificationXref
id: SMP0000327
db: SMPDB

Reference/PubChem-compound 152954
type: UnificationXref
id: 152954
db: PubChem-compound

UDP-glucuronosyltransferase 1-1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: UDP-glucuronosyltransferase 1-1

Interaction2851
type: MolecularInteraction
interaction type: direct_interaction
name: Calcium + Troponin activates Tropomyosin
participant: Calcium_Troponin
participant: Tropomyosin

Compound/PW C000921 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Compound/PW C000458 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sodium
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000380
type: UnificationXref
id: PW000380
db: PathWhiz

Reference/PubChem-compound 135250
type: UnificationXref
id: 135250
db: PubChem-compound

Compound/PW C000201 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc CA+2
type: UnificationXref
id: CA%2b2
db: BioCyc

Compound/PW C040702 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phenytoin methylcatechol
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/UniProt P05177
type: UnificationXref
id: P05177
db: UniProt

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/UniProt P10644
type: UnificationXref
id: P10644
db: UniProt

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Protein/5740 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 78 kDa glucose-regulated protein
stoichiometric coefficient: 1.0

Reference/UniProt P08684
type: UnificationXref
id: P08684
db: UniProt

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Reference/PubChem-compound 271
type: UnificationXref
id: 271
db: PubChem-compound

Reference/UniProt P32418
type: UnificationXref
id: P32418
db: UniProt

Protein/5742 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein disulfide-isomerase A2
stoichiometric coefficient: 1.0

ATP-binding cassette sub-family C member 8
type: Protein
entity reference: ATP-binding cassette sub-family C member 8

Epoxide hydrolase 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Epoxide hydrolase 1

Peptidyl-prolyl cis-trans isomerase B
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Peptidyl-prolyl cis-trans isomerase B

ATPase, (Na+)/K+ transporting, beta 4 polypeptide
type: Protein
entity reference: ATPase, (Na+)/K+ transporting, beta 4 polypeptide

Alpha-1-syntrophin
type: Protein
cellular location: Cell Membrane
entity reference: Alpha-1-syntrophin

Protein/4776 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Peptidyl-prolyl cis-trans isomerase B
stoichiometric coefficient: 1.0

Reference/UniProt P05181
type: UnificationXref
id: P05181
db: UniProt

Reference/PubChem-compound 17732
type: UnificationXref
id: 17732
db: PubChem-compound

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000746
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P19224
type: UnificationXref
id: P19224
db: UniProt

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADP

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: S-Adenosylhomocysteine

Reference/ChEBI CHEBI 17659
type: UnificationXref
id: CHEBI:17659
db: ChEBI

Protein/1845 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Voltage-dependent L-type calcium channel subunit alpha-1C
stoichiometric coefficient: 1.0

Reference/UniProt P08588
type: UnificationXref
id: P08588
db: UniProt

Protein/5741 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: HYOU1 protein
stoichiometric coefficient: 1.0

TransportCatalysis89
type: Catalysis
controller: Potassium channel subfamily K member 1
controlled: Transport116
control type: ACTIVATION

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

TransportCatalysis88
type: Catalysis
controller: ATP-sensitive inward rectifier potassium channel (IKATP)
controlled: Transport116
control type: ACTIVATION

Beta-2-syntrophin
type: Protein
cellular location: Cell Membrane
entity reference: Beta-2-syntrophin

TransportCatalysis87
type: Catalysis
controller: Voltage-gated rapid delayed rectifying potassium channel (IKr)
controlled: Transport116
control type: ACTIVATION

Reference/ChemSpider 148411
type: UnificationXref
id: 148411
db: ChemSpider

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

TransportCatalysis82
type: Catalysis
controller: Inward rectifier potassium channel (IK1)
controlled: Transport116
control type: ACTIVATION

Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
type: ProteinReference
xref: Reference/UniProt Q5I7T1

Beta-1-syntrophin
type: Protein
entity reference: Beta-1-syntrophin

Tropomyosin beta chain
type: ProteinReference
xref: Reference/UniProt P07951
organism: BiologicalState50

TransportCatalysis86
type: Catalysis
controller: Voltage-gated slow delayed rectifying potassium channel (IK5)
controlled: Transport116
control type: ACTIVATION

Muscarinic acetylcholine receptor M2
type: Protein
cellular location: Cell Membrane
entity reference: Muscarinic acetylcholine receptor M2
name: SubPathwayActivator

TransportCatalysis85
type: Catalysis
controller: Voltage-gated ultra rapid delayed rectifying potassium channel
controlled: Transport116
control type: ACTIVATION

Sodium/potassium-transporting ATPase subunit gamma
type: Protein
entity reference: Sodium/potassium-transporting ATPase subunit gamma

TransportCatalysis84
type: Catalysis
controller: Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto)
controlled: Transport116
control type: ACTIVATION

Calcium
type: SmallMolecule
cellular location: Sarcoplasmic Reticulum
entity reference: Calcium

Tropomyosin alpha-1 chain
type: ProteinReference
xref: Reference/UniProt P09493
organism: BiologicalState50

TransportCatalysis83
type: Catalysis
controller: Acetylcholine-activated potassium channel (IKACh)
controlled: Transport116
control type: ACTIVATION