Reference/CAS 454-29-5
type: UnificationXref
id: 454-29-5
db: CAS

Reference/KEGG Compound C00315
type: UnificationXref
id: C00315
db: KEGG Compound

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/BioCyc CYS
type: UnificationXref
id: CYS
db: BioCyc

Reference/ChEBI CHEBI 16134
type: UnificationXref
id: CHEBI:16134
db: ChEBI

S-methyl-5'-thioadenosine phosphorylase
type: ProteinReference
xref: Reference/UniProt Q13126
organism: Homo sapiens

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/ChemSpider 57
type: UnificationXref
id: 57
db: ChemSpider

Reference/HMDB HMDB0000092
type: UnificationXref
id: HMDB0000092
db: HMDB

Reference/HMDB HMDB0000097
type: UnificationXref
id: HMDB0000097
db: HMDB

Reference/BioCyc 10-FORMYL-THF
type: UnificationXref
id: 10-FORMYL-THF
db: BioCyc

Reference/HMDB HMDB0001185
type: UnificationXref
id: HMDB0001185
db: HMDB

Reference/HMDB HMDB0000099
type: UnificationXref
id: HMDB0000099
db: HMDB

Reference/ChEBI CHEBI 20506
type: UnificationXref
id: CHEBI:20506
db: ChEBI

Reference/ChEBI CHEBI 17115
type: UnificationXref
id: CHEBI:17115
db: ChEBI

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/ChEBI CHEBI 17119
type: UnificationXref
id: CHEBI:17119
db: ChEBI

Reference/KEGG Compound C00440
type: UnificationXref
id: C00440
db: KEGG Compound

Reference/ChEBI CHEBI 17230
type: UnificationXref
id: CHEBI:17230
db: ChEBI

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 6137
type: UnificationXref
id: 6137
db: PubChem-compound

Reference/BioCyc 5-METHYL-THF
type: UnificationXref
id: 5-METHYL-THF
db: BioCyc

S-adenosylmethionine synthase isoform type-2
type: ProteinReference
xref: Reference/UniProt P31153
organism: Homo sapiens

Reference/ChemSpider 18714427
type: UnificationXref
id: 18714427
db: ChemSpider

Reference/CAS 124-20-9
type: UnificationXref
id: 124-20-9
db: CAS

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Glycine N-methyltransferase
type: ProteinReference
xref: Reference/UniProt Q14749
organism: Homo sapiens

Protein/511 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Cystathionine gamma-lyase
stoichiometric coefficient: 4.0

βine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: βine

Tetrahydrofolic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetrahydrofolic acid

S-Adenosylmethionine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 24762165
xref: Reference/KEGG Compound C00019
xref: Reference/ChemSpider 31983
xref: Reference/ChEBI CHEBI 15414
xref: Reference/CAS 485-80-3
xref: Reference/BioCyc S-ADENOSYLMETHIONINE
xref: Reference/HMDB HMDB0001185
chemical formula: C15H23N6O5S
molecular weight: 399.14505
structure: ChemicalStructure/PW C000921

Compound/PW C000921 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/KEGG Compound C00213
type: UnificationXref
id: C00213
db: KEGG Compound

Reference/ChEBI CHEBI 17561
type: UnificationXref
id: CHEBI:17561
db: ChEBI

Reference/KEGG Compound C00212
type: UnificationXref
id: C00212
db: KEGG Compound

Reference/PathWhiz PW000040
type: UnificationXref
id: PW000040
db: PathWhiz

Reference/ChEBI CHEBI 15022
type: UnificationXref
id: CHEBI:15022
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Reference/PubChem-compound 439176
type: UnificationXref
id: 439176
db: PubChem-compound

Methionine adenosyltransferase 2 subunit beta
type: Protein
cellular location: Cytosol
entity reference: Methionine adenosyltransferase 2 subunit beta

Reference/PubChem-compound 439175
type: UnificationXref
id: 439175
db: PubChem-compound

Reference/UniProt P42898
type: UnificationXref
id: P42898
db: UniProt

Reference/BioCyc L-CYSTATHIONINE
type: UnificationXref
id: L-CYSTATHIONINE
db: BioCyc

ReactionCatalysis724
type: Catalysis
controller: Cystathionine beta-synthase
controlled: 4.2.1.22
control type: ACTIVATION

Reference/CAS 107-43-7
type: UnificationXref
id: 107-43-7
db: CAS

10-Formyltetrahydrofolate
type: SmallMolecule
cellular location: Cytosol
entity reference: 10-Formyltetrahydrofolate

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Reference/ChemSpider 5736
type: UnificationXref
id: 5736
db: ChemSpider

Compound/PW C000034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00109
type: UnificationXref
id: C00109
db: KEGG Compound

Reference/PathWhiz PW000157
type: UnificationXref
id: PW000157
db: PathWhiz

Reference/BioCyc METHYLENE-THF
type: UnificationXref
id: METHYLENE-THF
db: BioCyc

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/ChemSpider 824
type: UnificationXref
id: 824
db: ChemSpider

Compound/PW C000078 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00101
type: UnificationXref
id: C00101
db: KEGG Compound

Reference/ChEBI CHEBI 15033
type: UnificationXref
id: CHEBI:15033
db: ChEBI

Compound/PW C001342 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methionine sulfoxide
stoichiometric coefficient: 1.0

ReactionCatalysis717
type: Catalysis
controller: Serine hydroxymethyltransferase, cytosolic
controlled: 2.1.2.1
control type: ACTIVATION

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

ChemicalStructure/PW C001092
type: ChemicalStructure
structure format: SMILES
structure data: NCCCCN

Reference/CAS 72843-83-5
type: UnificationXref
id: 72843-83-5
db: CAS

Serine hydroxymethyltransferase, cytosolic
type: Protein
cellular location: Cytosol
entity reference: Serine hydroxymethyltransferase, cytosolic

ReactionCatalysis750
type: Catalysis
controller: Cystathionine gamma-lyase
controlled: 4.4.1.1
control type: ACTIVATION

Reference/ChEBI CHEBI 17148
type: UnificationXref
id: CHEBI:17148
db: ChEBI

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C000971 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Spermidine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000921
type: ChemicalStructure
structure format: SMILES

Reference/CAS 979-92-0
type: UnificationXref
id: 979-92-0
db: CAS

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Spermidine synthase
type: Complex
component stoichiometry: Protein/212 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Spermidine synthase

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00114
type: UnificationXref
id: C00114
db: KEGG Compound

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00234
type: UnificationXref
id: C00234
db: KEGG Compound

S-Adenosylhomocysteine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 25246222
xref: Reference/ChemSpider 388301
xref: Reference/BioCyc ADENOSYL-HOMO-CYS
xref: Reference/CAS 979-92-0
xref: Reference/KEGG Compound C00021
xref: Reference/ChEBI CHEBI 16680
xref: Reference/HMDB HMDB0000939
chemical formula: C14H20N6O5S
molecular weight: 384.12158
structure: ChemicalStructure/PW C000749

Dimethylglycine
type: SmallMolecule
cellular location: Cytosol
entity reference: Dimethylglycine

Reference/BioCyc SARCOSINE
type: UnificationXref
id: SARCOSINE
db: BioCyc

Reference/UniProt Q8IXL7
type: UnificationXref
id: Q8IXL7
db: UniProt

Reference/PubChem-compound 122347
type: UnificationXref
id: 122347
db: PubChem-compound

Compound/Generic40 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced acceptor
stoichiometric coefficient: 1.0

2.1.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000120 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001178 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Cytosol/Stoichiometry/1.0
right: Glycine
right: 5,10-Methylene-THF
right: Water
spontaneous: false
EC number: 2.1.2.1
left: Tetrahydrofolic acid
left: L-Serine
name: L-Serine + Tetrahydrofolic acid → 5,10-Methylene-THF + Glycine + Water
conversion direction: LEFT_TO_RIGHT

Glycine
type: SmallMolecule
cellular location: Nucleus
entity reference: Glycine

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/CAS 110-60-1
type: UnificationXref
id: 110-60-1
db: CAS

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Adenosine
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/ChemSpider 388321
type: UnificationXref
id: 388321
db: ChemSpider

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/CAS 135-16-0
type: UnificationXref
id: 135-16-0
db: CAS

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/BioCyc 2-OXOBUTANOATE
type: UnificationXref
id: 2-OXOBUTANOATE
db: BioCyc

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Compound/PW C000062 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dimethylglycine
stoichiometric coefficient: 1.0

Reference/ChemSpider 388320
type: UnificationXref
id: 388320
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/ChEBI CHEBI 49033
type: UnificationXref
id: CHEBI:49033
db: ChEBI

Cystathionine gamma-lyase
type: Complex
component stoichiometry: Protein/511 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Cystathionine gamma-lyase

Reference/UniProt Q8NE62
type: UnificationXref
id: Q8NE62
db: UniProt

Cystathionine gamma-lyase
type: Protein
cellular location: Cytosol
entity reference: Cystathionine gamma-lyase

Methionine--tRNA ligase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt P56192
organism: Homo sapiens

Betaine--homocysteine S-methyltransferase 1
type: Protein
cellular location: Cytosol
entity reference: Betaine--homocysteine S-methyltransferase 1

SubPathwayInteraction135
type: Interaction
name: SubPathway135Reaction
name: SubPathwayReaction
participant: L-Cysteine

Reference/KEGG Compound C00019
type: UnificationXref
id: C00019
db: KEGG Compound

Compound/Generic72 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: oxidized thioredoxin
stoichiometric coefficient: 1.0

ReactionCatalysis774
type: Catalysis
controller: L-amino-acid oxidase
controlled: 1.4.3.2
control type: ACTIVATION

ReactionCatalysis771
type: Catalysis
controller: Methionine-R-sulfoxide reductase B3
controlled: 1.8.4.-
control type: ACTIVATION

SubPathwayInteraction136
type: Interaction
name: SubPathwayReaction
name: SubPathway136Reaction
participant: Homocysteine

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Methionine--tRNA ligase, cytoplasmic
type: Protein
cellular location: Cytosol
entity reference: Methionine--tRNA ligase, cytoplasmic

Reference/ChEBI CHEBI 17482
type: UnificationXref
id: CHEBI:17482
db: ChEBI

2.4.2.28
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000548 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000910 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000770 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: 5-Methylthioribose 1-phosphate
right: L-Methionine
spontaneous: false
EC number: 2.4.2.28
left: Phosphate
left: 5'-Methylthioadenosine
name: 5'-Methylthioadenosine + Phosphate → 5-Methylthioribose 1-phosphate + L-Methionine
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

S-adenosylmethionine synthase isoform type-2
type: Protein
cellular location: Cytosol
entity reference: S-adenosylmethionine synthase isoform type-2

Reference/KEGG Compound C00014
type: UnificationXref
id: C00014
db: KEGG Compound

Reference/KEGG Compound C00134
type: UnificationXref
id: C00134
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

2.1.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000067 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000590 Cytosol/Stoichiometry/1.0
right: Homocysteine
spontaneous: false
EC number: 2.1.1.5
left: L-Cystathionine
name: L-Cystathionine → Homocysteine
conversion direction: LEFT_TO_RIGHT

4.4.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000003 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000067 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytosol/Stoichiometry/1.0
right: L-Cysteine
right: 2-Ketobutyric acid
spontaneous: false
EC number: 4.4.1.1
left: L-Cystathionine
left: Water
name: L-Cystathionine + Water → 2-Ketobutyric acid + L-Cysteine
conversion direction: LEFT_TO_RIGHT

1.8.4.-
type: BiochemicalReaction
participant stoichiometry: Compound/Generic72 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic73 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001342 Mitochondrion/Stoichiometry/1.0
right: Methionine sulfoxide
right: reduced thioredoxin
spontaneous: false
EC number: 1.8.4.-
left: L-Methionine
left: oxidized thioredoxin
name: L-Methionine + oxidized thioredoxin → Methionine sulfoxide + reduced thioredoxin
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P19623
type: UnificationXref
id: P19623
db: UniProt

Spermidine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00315
xref: Reference/HMDB HMDB0001257
xref: Reference/ChEBI CHEBI 16610
xref: Reference/CAS 124-20-9
xref: Reference/BioCyc SPERMIDINE
xref: Reference/PubChem-compound 1102
xref: Reference/ChemSpider 1071
chemical formula: C7H19N3
molecular weight: 145.1579
structure: ChemicalStructure/PW C000971

ReactionCatalysis408
type: Catalysis
controller: Spermidine synthase
controlled: 2.5.1.16
control type: ACTIVATION

ReactionCatalysis769
type: Catalysis
controller: Choline dehydrogenase, mitochondrial
controlled: 1.1.99.1
control type: ACTIVATION

4.1.1.50
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000783 Cytosol/Stoichiometry/1.0
right: Carbon dioxide
right: S-Adenosylmethioninamine
spontaneous: false
EC number: 4.1.1.50
left: S-Adenosylmethionine
name: S-Adenosylmethionine → Carbon dioxide + S-Adenosylmethioninamine
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis764
type: Catalysis
controller: S-methyl-5'-thioadenosine phosphorylase
controlled: 2.4.2.28
control type: ACTIVATION

SubPathwayInteraction133
type: Interaction
name: SubPathwayReaction
name: SubPathway133Reaction
participant: L-Homoserine

Reference/ChemSpider 12126
type: UnificationXref
id: 12126
db: ChemSpider

ReactionCatalysis762
type: Catalysis
controller: S-adenosylmethionine decarboxylase proenzyme
controlled: 4.1.1.50
control type: ACTIVATION

Reference/ChemSpider 388301
type: UnificationXref
id: 388301
db: ChemSpider

Reference/ChemSpider 1057
type: UnificationXref
id: 1057
db: ChemSpider

ChemicalStructure/PW C000910
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00143
type: UnificationXref
id: C00143
db: KEGG Compound

Reference/KEGG Compound C00263
type: UnificationXref
id: C00263
db: KEGG Compound

Reference/BioCyc MET
type: UnificationXref
id: MET
db: BioCyc

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00021
type: UnificationXref
id: C00021
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/CAS 56-88-2
type: UnificationXref
id: 56-88-2
db: CAS

Reference/ChemSpider 5653
type: UnificationXref
id: 5653
db: ChemSpider

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/CAS 3432-99-3
type: UnificationXref
id: 3432-99-3
db: CAS

4.2.1.22
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000120 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000570 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000067 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: L-Cystathionine
right: Water
spontaneous: false
EC number: 4.2.1.22
left: L-Homoserine
left: L-Serine
name: L-Homoserine + L-Serine → L-Cystathionine + Water
conversion direction: LEFT_TO_RIGHT

Methylenetetrahydrofolate reductase
type: Protein
cellular location: Cytosol
entity reference: Methylenetetrahydrofolate reductase

Reference/CAS 1118-68-9
type: UnificationXref
id: 1118-68-9
db: CAS

ReactionCatalysis759
type: Catalysis
controller: Betaine--homocysteine S-methyltransferase 1
controlled: 2.1.1.5
control type: ACTIVATION

L-Methionine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000696
xref: Reference/ChEBI CHEBI 16643
xref: Reference/KEGG Compound C00073
xref: Reference/CAS 63-68-3
xref: Reference/BioCyc MET
xref: Reference/PubChem-compound 6137
xref: Reference/ChemSpider 5907
chemical formula: C5H11NO2S
molecular weight: 149.05106
structure: ChemicalStructure/PW C000548

Reference/BioCyc PUTRESCINE
type: UnificationXref
id: PUTRESCINE
db: BioCyc

Reference/CAS 52-90-4
type: UnificationXref
id: 52-90-4
db: CAS

Reference/KEGG Compound C00037
type: UnificationXref
id: C00037
db: KEGG Compound

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 653
type: UnificationXref
id: 653
db: ChemSpider

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Reference/ChEBI CHEBI 29173
type: UnificationXref
id: CHEBI:29173
db: ChEBI

L-Methionyl-tRNA(Met)
type: RnaReference
xref: Reference/ChEBI CHEBI 16635
organism: Homo sapiens

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

N-formylmethionyl-tRNA(fMet)
type: RnaReference
xref: Reference/ChEBI CHEBI 17119
organism: Homo sapiens

Reference/KEGG Compound C01137
type: UnificationXref
id: C01137
db: KEGG Compound

Reference/CAS 107-97-1
type: UnificationXref
id: 107-97-1
db: CAS

5-Methylthioribose 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Methylthioribose 1-phosphate

ChemicalStructure/PW C000065
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CCO

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

6.1.1.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000548 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: RNA/17 Cytosol/Stoichiometry/1.0
participant stoichiometry: RNA/9 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: Adenosine monophosphate
right: Pyrophosphate
right: L-Methionyl-tRNA(Met)
spontaneous: false
EC number: 6.1.1.10
left: tRNA(Met)
left: Adenosine triphosphate
left: L-Methionine
name: Adenosine triphosphate + L-Methionine + tRNA(Met) → Adenosine monophosphate + L-Methionyl-tRNA(Met) + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000185
type: ChemicalStructure
structure format: SMILES
structure data: CNCC(O)=O

1.1.99.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000065 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic40 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic41 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000030 Mitochondrion/Stoichiometry/1.0
right: Reduced acceptor
right: βine
spontaneous: false
EC number: 1.1.99.1
left: Choline
left: Acceptor
name: Acceptor + Choline → Reduced acceptor + βine
conversion direction: LEFT_TO_RIGHT

1.8.4.-
type: BiochemicalReaction
participant stoichiometry: Compound/Generic72 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000548 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic73 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001342 Mitochondrion/Stoichiometry/1.0
right: Methionine sulfoxide
right: reduced thioredoxin
spontaneous: false
EC number: 1.8.4.-
left: L-Methionine
left: oxidized thioredoxin
name: L-Methionine + oxidized thioredoxin → Methionine sulfoxide + reduced thioredoxin
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000067
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O

Reference/KEGG Compound C00170
type: UnificationXref
id: C00170
db: KEGG Compound

Protein/389 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: S-methyl-5'-thioadenosine phosphorylase
stoichiometric coefficient: 3.0

Cystathionine beta-synthase
type: Protein
cellular location: Cytosol
entity reference: Cystathionine beta-synthase

Reference/ChemSpider 388529
type: UnificationXref
id: 388529
db: ChemSpider

ChemicalStructure/PW C000062
type: ChemicalStructure
structure format: SMILES
structure data: CN(C)CC(O)=O

Compound/PW C000120 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Serine
stoichiometric coefficient: 1.0

Compound/PW C001092 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Putrescine
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-479
type: UnificationXref
id: CPD-479
db: BioCyc

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

4.2.1.22
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000120 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000067 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000590 Cytosol/Stoichiometry/1.0
right: Water
right: L-Cystathionine
spontaneous: false
EC number: 4.2.1.22
left: L-Serine
left: Homocysteine
name: Homocysteine + L-Serine → L-Cystathionine + Water
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 53477720
type: UnificationXref
id: 53477720
db: PubChem-compound

Compound/PW C001195 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Oxo-4-methylthiobutanoic acid
stoichiometric coefficient: 1.0

Protein/724 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Cystathionine beta-synthase
stoichiometric coefficient: 4.0

Reference/PubChem-compound 305
type: UnificationXref
id: 305
db: PubChem-compound

Protein/411 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: S-adenosylmethionine decarboxylase proenzyme
stoichiometric coefficient: 4.0

Reference/PubChem-compound 12647
type: UnificationXref
id: 12647
db: PubChem-compound

Reference/UniProt P32929
type: UnificationXref
id: P32929
db: UniProt

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/KEGG Compound C01026
type: UnificationXref
id: C01026
db: KEGG Compound

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reduced acceptor
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Reduced acceptor

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000030
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CC([O-])=O

Reference/BioCyc AMMONIA
type: UnificationXref
id: AMMONIA
db: BioCyc

ChemicalStructure/PW C000035
type: ChemicalStructure
structure format: SMILES
structure data: N

ChemicalStructure/PW C000034
type: ChemicalStructure
structure format: SMILES

Reference/CAS 63-68-3
type: UnificationXref
id: 63-68-3
db: CAS

Reference/HMDB HMDB0000271
type: UnificationXref
id: HMDB0000271
db: HMDB

5,10-Methylene-THF
type: SmallMolecule
cellular location: Cytosol
entity reference: 5,10-Methylene-THF

5-Methylthioribose 1-phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C04188
xref: Reference/PubChem-compound 53477720
xref: Reference/HMDB HMDB0000963
xref: Reference/BioCyc CPD-444
xref: Reference/ChEBI CHEBI 27859
xref: Reference/CAS 72843-83-5
chemical formula: C6H13O7PS
molecular weight: 260.01196
structure: ChemicalStructure/PW C000770

Reference/ChemSpider 5907
type: UnificationXref
id: 5907
db: ChemSpider

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

10-Formyltetrahydrofolate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000972
xref: Reference/PubChem-compound 122347
xref: Reference/ChemSpider 109092
xref: Reference/ChEBI CHEBI 15637
xref: Reference/CAS 2800-34-2
xref: Reference/BioCyc 10-FORMYL-THF
xref: Reference/KEGG Compound C00234
chemical formula: C20H23N7O7
molecular weight: 473.1659
structure: ChemicalStructure/PW C000774

Reference/CAS 56-40-6
type: UnificationXref
id: 56-40-6
db: CAS

Reference/KEGG Compound C00065
type: UnificationXref
id: C00065
db: KEGG Compound

Compound/PW C000770 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Methylthioribose 1-phosphate
stoichiometric coefficient: 1.0

Reference/CAS 58-61-7
type: UnificationXref
id: 58-61-7
db: CAS

Reference/CAS 2800-34-2
type: UnificationXref
id: 2800-34-2
db: CAS

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylhomocysteine

Spermidine synthase
type: ProteinReference
xref: Reference/UniProt P19623
organism: Homo sapiens

Reference/HMDB HMDB0001257
type: UnificationXref
id: HMDB0001257
db: HMDB

Compound/PW C000035 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonia
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00073
type: UnificationXref
id: C00073
db: KEGG Compound

S-Adenosylmethioninamine
type: SmallMoleculeReference
xref: Reference/CAS 22365-13-5
xref: Reference/ChEBI CHEBI 15625
xref: Reference/HMDB HMDB0000988
xref: Reference/ChemSpider 388529
xref: Reference/PubChem-compound 439415
xref: Reference/KEGG Compound C01137
xref: Reference/BioCyc S-ADENOSYLMETHIONINAMINE
chemical formula: C14H23N6O3S
molecular weight: 355.15524
structure: ChemicalStructure/PW C000783

Reference/HMDB HMDB0000043
type: UnificationXref
id: HMDB0000043
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/BioCyc DIMETHYL-GLYCINE
type: UnificationXref
id: DIMETHYL-GLYCINE
db: BioCyc

Reference/ChemSpider 31983
type: UnificationXref
id: 31983
db: ChemSpider

Methionine sulfoxide
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Methionine sulfoxide

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen peroxide

Reference/UniProt P17707
type: UnificationXref
id: P17707
db: UniProt

Protein/183 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Methylenetetrahydrofolate reductase
stoichiometric coefficient: 2.0

Reference/ChemSpider 730
type: UnificationXref
id: 730
db: ChemSpider

Reference/BioCyc BETAINE
type: UnificationXref
id: BETAINE
db: BioCyc

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/CAS 583-92-6
type: UnificationXref
id: 583-92-6
db: CAS

Reference/UniProt P56192
type: UnificationXref
id: P56192
db: UniProt

Reference/PubChem-compound 847
type: UnificationXref
id: 847
db: PubChem-compound

Reference/HMDB HMDB0000051
type: UnificationXref
id: HMDB0000051
db: HMDB

Reference/HMDB HMDB0000050
type: UnificationXref
id: HMDB0000050
db: HMDB

Compound/PW C000774 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 10-Formyltetrahydrofolate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

βine
type: SmallMolecule
cellular location: Cytosol
entity reference: βine

Homocysteine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C05330
xref: Reference/CAS 454-29-5
xref: Reference/HMDB HMDB0000742
xref: Reference/ChEBI CHEBI 17230
xref: Reference/ChemSpider 757
xref: Reference/PubChem-compound 49791978
xref: Reference/BioCyc HOMO-CYS
chemical formula: C4H9NO2S
molecular weight: 135.0354
structure: ChemicalStructure/PW C000590

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

S-adenosylmethionine synthase
type: Complex
component stoichiometry: Protein/397 Cytosol/Stoichiometry/2.0
component stoichiometry: Protein/2387 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Methionine adenosyltransferase 2 subunit beta
component: S-adenosylmethionine synthase isoform type-2

Putrescine
type: SmallMolecule
cellular location: Cytosol
entity reference: Putrescine

Compound/PW C000590 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Homocysteine
stoichiometric coefficient: 1.0

Cystathionine gamma-lyase
type: ProteinReference
xref: Reference/UniProt P32929
organism: Homo sapiens

Reference/BioCyc HOMO-CYS
type: UnificationXref
id: HOMO-CYS
db: BioCyc

Reference/HMDB HMDB0002005
type: UnificationXref
id: HMDB0002005
db: HMDB

Reference/KEGG Compound C01180
type: UnificationXref
id: C01180
db: KEGG Compound

ChemicalStructure/PW C001079
type: ChemicalStructure
structure format: SMILES

2-Ketobutyric acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 30831
xref: Reference/HMDB HMDB0000005
xref: Reference/CAS 600-18-0
xref: Reference/ChemSpider 57
xref: Reference/KEGG Compound C00109
xref: Reference/PubChem-compound 58
xref: Reference/BioCyc 2-OXOBUTANOATE
chemical formula: C4H6O3
molecular weight: 102.03169
structure: ChemicalStructure/PW C000003

Compound/PW C000548 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

L-Serine
type: SmallMoleculeReference
xref: Reference/ChemSpider 5736
xref: Reference/ChEBI CHEBI 17115
xref: Reference/CAS 56-45-1
xref: Reference/KEGG Compound C00065
xref: Reference/PubChem-compound 5951
xref: Reference/HMDB HMDB0000187
xref: Reference/BioCyc SER
chemical formula: C3H7NO3
molecular weight: 105.042595
structure: ChemicalStructure/PW C000120

ChemicalStructure/PW C001195
type: ChemicalStructure
structure format: SMILES
structure data: CSCCC(=O)C(O)=O

Reference/HMDB HMDB0000187
type: UnificationXref
id: HMDB0000187
db: HMDB

Compound/PW C000749 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001396
type: UnificationXref
id: HMDB0001396
db: HMDB

Compound/PW C000003 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2-Ketobutyric acid
stoichiometric coefficient: 1.0

L-Cysteine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000574
xref: Reference/CAS 52-90-4
xref: Reference/KEGG Compound C00097
xref: Reference/BioCyc CYS
xref: Reference/ChemSpider 5653
xref: Reference/PubChem-compound 5862
xref: Reference/ChEBI CHEBI 17561
chemical formula: C3H7NO2S
molecular weight: 121.01975
structure: ChemicalStructure/PW C000448

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Reference/ChEBI CHEBI 33574
type: UnificationXref
id: CHEBI:33574
db: ChEBI

Compound/PW C000570 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Homoserine
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00097
type: UnificationXref
id: C00097
db: KEGG Compound

Reference/ChemSpider 757
type: UnificationXref
id: 757
db: ChemSpider

N-formylmethionyl-tRNA(fMet)
type: Rna
cellular location: Cytosol
entity reference: N-formylmethionyl-tRNA(fMet)

Glycine
type: SmallMolecule
cellular location: Cytosol
entity reference: Glycine

Reference/PubChem-compound 25246222
type: UnificationXref
id: 25246222
db: PubChem-compound

Compound/PW C001221 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetrahydrofolic acid
stoichiometric coefficient: 1.0

Compound/PW C000065 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Choline
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

ChemicalStructure/PW C000078
type: ChemicalStructure
structure format: SMILES
structure data: NCC(O)=O

RNA/9 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: tRNA(Met)
stoichiometric coefficient: 1.0

Reference/ChemSpider 54923
type: UnificationXref
id: 54923
db: ChemSpider

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

L-Homoserine
type: SmallMoleculeReference
xref: Reference/BioCyc HOMO-SER
xref: Reference/ChEBI CHEBI 15699
xref: Reference/CAS 672-15-1
xref: Reference/KEGG Compound C00263
xref: Reference/PubChem-compound 12647
xref: Reference/HMDB HMDB0000719
xref: Reference/ChemSpider 12126
chemical formula: C4H9NO3
molecular weight: 119.05824
structure: ChemicalStructure/PW C000570

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Choline
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Choline

Compound/PW C000548 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/BioCyc SPERMIDINE
type: UnificationXref
id: SPERMIDINE
db: BioCyc

Compound/PW C001316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

Protein/397 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: S-adenosylmethionine synthase isoform type-2
stoichiometric coefficient: 2.0

Reference/CAS 62-49-7
type: UnificationXref
id: 62-49-7
db: CAS

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Betaine--homocysteine S-methyltransferase 1
type: ProteinReference
xref: Reference/UniProt Q93088
organism: Homo sapiens

S-adenosylmethionine decarboxylase proenzyme
type: ProteinReference
xref: Reference/UniProt P17707
organism: Homo sapiens

Reference/KEGG Compound C02291
type: UnificationXref
id: C02291
db: KEGG Compound

ChemicalStructure/PW C001178
type: ChemicalStructure
structure format: SMILES

Reference/CAS 134-35-0
type: UnificationXref
id: 134-35-0
db: CAS

L-Homoserine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Homoserine
name: SubPathwayOutput

Reference/HMDB HMDB0001173
type: UnificationXref
id: HMDB0001173
db: HMDB

Reference/PubChem-compound 247
type: UnificationXref
id: 247
db: PubChem-compound

Reference/CAS 2457-80-9
type: UnificationXref
id: 2457-80-9
db: CAS

2.5.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001092 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000971 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000910 Cytosol/Stoichiometry/1.0
right: 5'-Methylthioadenosine
right: Spermidine
spontaneous: false
EC number: 2.5.1.16
left: S-Adenosylmethioninamine
left: Putrescine
name: Putrescine + S-Adenosylmethioninamine → 5'-Methylthioadenosine + Spermidine
conversion direction: LEFT_TO_RIGHT

L-Methionine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Methionine

Reference/UniProt Q96RQ9
type: UnificationXref
id: Q96RQ9
db: UniProt

ChemicalStructure/PW C000448
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CS)C(O)=O

Compound/PW C001178 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5,10-Methylene-THF
stoichiometric coefficient: 1.0

Reference/KEGG Compound C05330
type: UnificationXref
id: C05330
db: KEGG Compound

Compound/PW C000749 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylhomocysteine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000570
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCO)C(O)=O

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine monophosphate

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/ChemSpider 13837702
type: UnificationXref
id: 13837702
db: ChemSpider

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Ammonia
type: SmallMoleculeReference
xref: Reference/BioCyc AMMONIA
xref: Reference/CAS 7664-41-7
xref: Reference/HMDB HMDB0000051
xref: Reference/PubChem-compound 222
xref: Reference/KEGG Compound C00014
xref: Reference/ChEBI CHEBI 16134
xref: Reference/ChemSpider 217
chemical formula: H3N
molecular weight: 17.026548
structure: ChemicalStructure/PW C000035

Adenosine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 60961
xref: Reference/ChEBI CHEBI 16335
xref: Reference/ChemSpider 54923
xref: Reference/HMDB HMDB0000050
xref: Reference/CAS 58-61-7
xref: Reference/KEGG Compound C00212
xref: Reference/BioCyc ADENOSINE
chemical formula: C10H13N5O4
molecular weight: 267.09674
structure: ChemicalStructure/PW C000034

Compound/PW C000030 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: βine
stoichiometric coefficient: 1.0

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

βine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 247
xref: Reference/BioCyc BETAINE
xref: Reference/ChemSpider 242
xref: Reference/KEGG Compound C00719
xref: Reference/CAS 107-43-7
xref: Reference/ChEBI CHEBI 17750
xref: Reference/HMDB HMDB0000043
chemical formula: C5H11NO2
molecular weight: 117.07898
structure: ChemicalStructure/PW C000030

L-amino-acid oxidase
type: ProteinReference
xref: Reference/UniProt Q96RQ9
organism: Homo sapiens

Reference/ChEBI CHEBI 15611
type: UnificationXref
id: CHEBI:15611
db: ChEBI

Compound/PW C001065 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Compound/PW C000067 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cystathionine
stoichiometric coefficient: 1.0

Reference/BioCyc S-ADENOSYLMETHIONINAMINE
type: UnificationXref
id: S-ADENOSYLMETHIONINAMINE
db: BioCyc

Reference/PubChem-compound 473
type: UnificationXref
id: 473
db: PubChem-compound

S-Adenosylmethionine
type: SmallMolecule
cellular location: Nucleus
entity reference: S-Adenosylmethionine

Sulfate/Sulfite Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway136
pathway component: SubPathwayInteraction136
xref: Reference/SMPDB SMP0000041
xref: Reference/PathWhiz PW000040
name: SubPathway

Reference/ChemSpider 242
type: UnificationXref
id: 242
db: ChemSpider

2-Ketobutyric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Ketobutyric acid

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

5-Methyltetrahydrofolic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 5-Methyltetrahydrofolic acid

Reference/PubChem-compound 58
type: UnificationXref
id: 58
db: PubChem-compound

Reference/PubChem-compound 49791978
type: UnificationXref
id: 49791978
db: PubChem-compound

Methionine-R-sulfoxide reductase B3
type: Protein
cellular location: Mitochondrion
entity reference: Methionine-R-sulfoxide reductase B3

L-Cystathionine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Cystathionine

S-adenosylmethionine decarboxylase proenzyme
type: Complex
component stoichiometry: Protein/411 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: S-adenosylmethionine decarboxylase proenzyme

Cystathionine beta-synthase
type: ProteinReference
xref: Reference/UniProt P35520
organism: Homo sapiens

Reference/UniProt Q93088
type: UnificationXref
id: Q93088
db: UniProt

ChemicalStructure/PW C000548
type: ChemicalStructure
structure format: SMILES
structure data: CSCC[C@H](N)C(O)=O

Acceptor
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acceptor

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Tetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 20506
xref: Reference/ChemSpider 18714427
xref: Reference/HMDB HMDB0001846
xref: Reference/PubChem-compound 13781857
xref: Reference/BioCyc THF
xref: Reference/CAS 135-16-0
xref: Reference/KEGG Compound C00101
chemical formula: C19H23N7O6
molecular weight: 445.171
structure: ChemicalStructure/PW C001221

Methionine sulfoxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002005
xref: Reference/ChEBI CHEBI 49033
xref: Reference/CAS 62697-73-8
xref: Reference/PubChem-compound 847
xref: Reference/ChemSpider 824
xref: Reference/BioCyc L-METHIONINE SULFOXIDE
chemical formula: C5H11NO3S
molecular weight: 165.04596
structure: ChemicalStructure/PW C001342

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Methionine-R-sulfoxide reductase B2, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Methionine-R-sulfoxide reductase B2, mitochondrial

Protein/212 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Spermidine synthase
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

ReactionCatalysis168
type: Catalysis
controller: S-adenosylmethionine synthase
controlled: 2.5.1.6
control type: ACTIVATION

ReactionCatalysis166
type: Catalysis
controller: Betaine--homocysteine S-methyltransferase 1
controlled: 2.1.1.5
control type: ACTIVATION

1.4.3.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000548 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001195 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000035 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: 2-Oxo-4-methylthiobutanoic acid
right: Ammonia
right: Hydrogen peroxide
spontaneous: false
EC number: 1.4.3.2
left: Oxygen
left: L-Methionine
left: Water
name: L-Methionine + Oxygen + Water → 2-Oxo-4-methylthiobutanoic acid + Ammonia + Hydrogen peroxide
conversion direction: LEFT_TO_RIGHT

Ammonia
type: SmallMolecule
cellular location: Cytosol
entity reference: Ammonia

2.1.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000548 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000030 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000590 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000062 Cytosol/Stoichiometry/1.0
right: Dimethylglycine
right: L-Methionine
spontaneous: false
EC number: 2.1.1.5
left: βine
left: Homocysteine
name: Homocysteine + βine → Dimethylglycine + L-Methionine
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc ADENOSYL-HOMO-CYS
type: UnificationXref
id: ADENOSYL-HOMO-CYS
db: BioCyc

Serine hydroxymethyltransferase, cytosolic
type: ProteinReference
xref: Reference/UniProt P34896
organism: Homo sapiens

S-Adenosylhomocysteine
type: SmallMolecule
cellular location: Nucleus
entity reference: S-Adenosylhomocysteine

1.5.1.20
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001178 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001079 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: NAD
right: 5-Methyltetrahydrofolic acid
spontaneous: false
EC number: 1.5.1.20
left: NADH
left: 5,10-Methylene-THF
name: 5,10-Methylene-THF + NADH → 5-Methyltetrahydrofolic acid + NAD
conversion direction: LEFT_TO_RIGHT

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Reference/CAS 485-80-3
type: UnificationXref
id: 485-80-3
db: CAS

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Protein/530 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Betaine--homocysteine S-methyltransferase 1
stoichiometric coefficient: 4.0

Reference/PubChem-compound 5862
type: UnificationXref
id: 5862
db: PubChem-compound

Reference/BioCyc SER
type: UnificationXref
id: SER
db: BioCyc

Reference/HMDB HMDB0001533
type: UnificationXref
id: HMDB0001533
db: HMDB

Cystathionine beta-synthase
type: Complex
component stoichiometry: Protein/724 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Cystathionine beta-synthase

Reference/HMDB HMDB0001414
type: UnificationXref
id: HMDB0001414
db: HMDB

Reference/CAS 600-18-0
type: UnificationXref
id: 600-18-0
db: CAS

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Reference/BioCyc THF
type: UnificationXref
id: THF
db: BioCyc

S-Adenosylmethioninamine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylmethioninamine

Reference/ChEBI CHEBI 15641
type: UnificationXref
id: CHEBI:15641
db: ChEBI

Reference/BioCyc GLY
type: UnificationXref
id: GLY
db: BioCyc

Reference/ChEBI CHEBI 16610
type: UnificationXref
id: CHEBI:16610
db: ChEBI

Reference/CAS 672-15-1
type: UnificationXref
id: 672-15-1
db: CAS

Carbon dioxide
type: SmallMolecule
cellular location: Cytosol
entity reference: Carbon dioxide

Compound/PW C000030 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: βine
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

L-Methionyl-tRNA(Met)
type: Rna
cellular location: Cytosol
entity reference: L-Methionyl-tRNA(Met)

Reference/ChemSpider 217
type: UnificationXref
id: 217
db: ChemSpider

ChemicalStructure/PW C001221
type: ChemicalStructure
structure format: SMILES

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/HMDB HMDB0000574
type: UnificationXref
id: HMDB0000574
db: HMDB

ChemicalStructure/PW C001342
type: ChemicalStructure
structure format: SMILES
structure data: CS(=O)CC[C@H](N)C(O)=O

Reference/HMDB HMDB0000696
type: UnificationXref
id: HMDB0000696
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

Reference/ChEBI CHEBI 15637
type: UnificationXref
id: CHEBI:15637
db: ChEBI

Glycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000123
xref: Reference/BioCyc GLY
xref: Reference/ChemSpider 730
xref: Reference/PubChem-compound 5257127
xref: Reference/CAS 56-40-6
xref: Reference/ChEBI CHEBI 15428
xref: Reference/KEGG Compound C00037
chemical formula: C2H5NO2
molecular weight: 75.03203
structure: ChemicalStructure/PW C000078

L-amino-acid oxidase
type: Protein
cellular location: Cytosol
entity reference: L-amino-acid oxidase

ReactionCatalysis1520
type: Catalysis
controller: Glycine N-methyltransferase
controlled: 2.1.1.20
control type: ACTIVATION

Reference/SMPDB SMP0000041
type: UnificationXref
id: SMP0000041
db: SMPDB

Reference/ChEBI CHEBI 15414
type: UnificationXref
id: CHEBI:15414
db: ChEBI

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Compound/Generic41 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acceptor
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 27859
type: UnificationXref
id: CHEBI:27859
db: ChEBI

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/PubChem-compound 673
type: UnificationXref
id: 673
db: PubChem-compound

Reference/HMDB HMDB0001553
type: UnificationXref
id: HMDB0001553
db: HMDB

Reference/PubChem-compound 5257127
type: UnificationXref
id: 5257127
db: PubChem-compound

5,10-Methylene-THF
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001533
xref: Reference/CAS 3432-99-3
xref: Reference/PubChem-compound 439175
xref: Reference/ChEBI CHEBI 15636
xref: Reference/KEGG Compound C00143
xref: Reference/BioCyc METHYLENE-THF
xref: Reference/ChemSpider 388320
chemical formula: C20H23N7O6
molecular weight: 457.171
structure: ChemicalStructure/PW C001178

Reference/CAS 7664-41-7
type: UnificationXref
id: 7664-41-7
db: CAS

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Reference/UniProt P35520
type: UnificationXref
id: P35520
db: UniProt

Glycine and Serine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway133
pathway component: SubPathwayInteraction133
xref: Reference/PathWhiz PW000157
xref: Reference/SMPDB SMP0000004
name: SubPathway

Reference/PubChem-compound 60961
type: UnificationXref
id: 60961
db: PubChem-compound

Reference/ChEBI CHEBI 15625
type: UnificationXref
id: CHEBI:15625
db: ChEBI

Reference/BioCyc S-ADENOSYLMETHIONINE
type: UnificationXref
id: S-ADENOSYLMETHIONINE
db: BioCyc

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/PubChem-compound 5951
type: UnificationXref
id: 5951
db: PubChem-compound

Reference/PubChem-compound 222
type: UnificationXref
id: 222
db: PubChem-compound

Homocysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: Homocysteine
name: SubPathwayOutput

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/KEGG Compound C04188
type: UnificationXref
id: C04188
db: KEGG Compound

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

ChemicalStructure/PW C000590
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCS)C(O)=O

Reference/PubChem-compound 439415
type: UnificationXref
id: 439415
db: PubChem-compound

Cysteine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway135
pathway component: SubPathwayInteraction135
xref: Reference/SMPDB SMP0000013
xref: Reference/PathWhiz PW000018
name: SubPathway

tRNA(Met)
type: Rna
cellular location: Cytosol
entity reference: tRNA(Met)

Reference/CAS 22365-13-5
type: UnificationXref
id: 22365-13-5
db: CAS

Reference/BioCyc CPD-444
type: UnificationXref
id: CPD-444
db: BioCyc

Reference/ChEBI CHEBI 15636
type: UnificationXref
id: CHEBI:15636
db: ChEBI

Reference/BioCyc CPD-563
type: UnificationXref
id: CPD-563
db: BioCyc

RNA/18 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-formylmethionyl-tRNA(fMet)
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1102
type: UnificationXref
id: 1102
db: PubChem-compound

Protein/2387 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methionine adenosyltransferase 2 subunit beta
stoichiometric coefficient: 1.0

reduced thioredoxin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15033

Reference/HMDB HMDB0000123
type: UnificationXref
id: HMDB0000123
db: HMDB

ChemicalStructure/PW C000120
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CO)C(O)=O

Choline dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Choline dehydrogenase, mitochondrial

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0000005
type: UnificationXref
id: HMDB0000005
db: HMDB

ChemicalStructure/PW C000003
type: ChemicalStructure
structure format: SMILES
structure data: CCC(=O)C(O)=O

Reference/ChemSpider 460
type: UnificationXref
id: 460
db: ChemSpider

L-Cystathionine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C02291
xref: Reference/BioCyc L-CYSTATHIONINE
xref: Reference/PubChem-compound 25243997
xref: Reference/ChEBI CHEBI 17482
xref: Reference/ChemSpider 388392
xref: Reference/CAS 56-88-2
xref: Reference/HMDB HMDB0000099
chemical formula: C7H14N2O4S
molecular weight: 222.06743
structure: ChemicalStructure/PW C000067

Choline
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15354
xref: Reference/ChemSpider 299
xref: Reference/BioCyc CPD-563
xref: Reference/PubChem-compound 305
xref: Reference/CAS 62-49-7
xref: Reference/HMDB HMDB0000097
xref: Reference/KEGG Compound C00114
chemical formula: C5H14NO
molecular weight: 104.10754
structure: ChemicalStructure/PW C000065

Sarcosine
type: SmallMoleculeReference
xref: Reference/CAS 107-97-1
xref: Reference/BioCyc SARCOSINE
xref: Reference/ChemSpider 1057
xref: Reference/ChEBI CHEBI 15611
xref: Reference/HMDB HMDB0000271
xref: Reference/KEGG Compound C00213
xref: Reference/PubChem-compound 1088
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C000185

Dimethylglycine
type: SmallMoleculeReference
xref: Reference/BioCyc DIMETHYL-GLYCINE
xref: Reference/ChemSpider 653
xref: Reference/CAS 1118-68-9
xref: Reference/ChEBI CHEBI 17724
xref: Reference/HMDB HMDB0000092
xref: Reference/PubChem-compound 673
xref: Reference/KEGG Compound C01026
chemical formula: C4H9NO2
molecular weight: 103.06333
structure: ChemicalStructure/PW C000062

Reference/PathWhiz PW000104
type: UnificationXref
id: PW000104
db: PathWhiz

Protein/739 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Serine hydroxymethyltransferase, cytosolic
stoichiometric coefficient: 4.0

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 30831
type: UnificationXref
id: CHEBI:30831
db: ChEBI

oxidized thioredoxin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15033

ChemicalStructure/PW C000971
type: ChemicalStructure
structure format: SMILES
structure data: NCCCCNCCCN

RNA/17 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Methionyl-tRNA(Met)
stoichiometric coefficient: 1.0

Compound/Generic73 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: reduced thioredoxin
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000004
type: UnificationXref
id: SMP0000004
db: SMPDB

Reference/KEGG Compound C00719
type: UnificationXref
id: C00719
db: KEGG Compound

Reference/BioCyc 5-METHYLTHIOADENOSINE
type: UnificationXref
id: 5-METHYLTHIOADENOSINE
db: BioCyc

Compound/PW C000448 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

oxidized thioredoxin
type: SmallMolecule
cellular location: Mitochondrion
entity reference: oxidized thioredoxin

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/ChEBI CHEBI 15699
type: UnificationXref
id: CHEBI:15699
db: ChEBI

Reference/ChEBI CHEBI 15339
type: UnificationXref
id: CHEBI:15339
db: ChEBI

Reference/ChemSpider 1071
type: UnificationXref
id: 1071
db: ChemSpider

Reference/ChEBI CHEBI 17750
type: UnificationXref
id: CHEBI:17750
db: ChEBI

S-Adenosylmethionine
type: SmallMolecule
cellular location: Cytosol
entity reference: S-Adenosylmethionine

Reference/PubChem-compound 1088
type: UnificationXref
id: 1088
db: PubChem-compound

Reference/HMDB HMDB0000939
type: UnificationXref
id: HMDB0000939
db: HMDB

Glycine N-methyltransferase
type: Protein
cellular location: Nucleus
entity reference: Glycine N-methyltransferase

Reference/ChEBI CHEBI 17509
type: UnificationXref
id: CHEBI:17509
db: ChEBI

Reference/SMPDB SMP0000013
type: UnificationXref
id: SMP0000013
db: SMPDB

Putrescine
type: SmallMoleculeReference
xref: Reference/CAS 110-60-1
xref: Reference/BioCyc PUTRESCINE
xref: Reference/ChEBI CHEBI 17148
xref: Reference/HMDB HMDB0001414
xref: Reference/ChemSpider 13837702
xref: Reference/KEGG Compound C00134
xref: Reference/PubChem-compound 1045
chemical formula: C4H12N2
molecular weight: 88.10005
structure: ChemicalStructure/PW C001092

Compound/PW C000032 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

ReactionCatalysis776
type: Catalysis
controller: Methionine--tRNA ligase, cytoplasmic
controlled: 6.1.1.10
control type: ACTIVATION

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChEBI CHEBI 16635
type: UnificationXref
id: CHEBI:16635
db: ChEBI

Reference/ChEBI CHEBI 17724
type: UnificationXref
id: CHEBI:17724
db: ChEBI

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Methionine adenosyltransferase 2 subunit beta
type: ProteinReference
xref: Reference/UniProt Q9NZL9
organism: Homo sapiens

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

S-methyl-5'-thioadenosine phosphorylase
type: Complex
component stoichiometry: Protein/389 Cytosol/Stoichiometry/3.0
cellular location: Cytosol
component: S-methyl-5'-thioadenosine phosphorylase

Acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15339

Reduced acceptor
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15022

Compound/PW C000921 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethionine
stoichiometric coefficient: 1.0

Compound/PW C000185 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Sarcosine
stoichiometric coefficient: 1.0

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

2-Oxo-4-methylthiobutanoic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 2-Oxo-4-methylthiobutanoic acid

Reference/UniProt Q14749
type: UnificationXref
id: Q14749
db: UniProt

Reference/UniProt P31153
type: UnificationXref
id: P31153
db: UniProt

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Compound/PW C000078 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

ReactionCatalysis321
type: Catalysis
controller: Methylenetetrahydrofolate reductase
controlled: 1.5.1.20
control type: ACTIVATION

Reference/ChEBI CHEBI 16643
type: UnificationXref
id: CHEBI:16643
db: ChEBI

Reference/UniProt P34896
type: UnificationXref
id: P34896
db: UniProt

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

Reference/HMDB HMDB0000719
type: UnificationXref
id: HMDB0000719
db: HMDB

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

2-Oxo-4-methylthiobutanoic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001553
xref: Reference/KEGG Compound C01180
xref: Reference/BioCyc CPD-479
xref: Reference/CAS 583-92-6
xref: Reference/ChEBI CHEBI 33574
xref: Reference/ChemSpider 460
xref: Reference/PubChem-compound 473
chemical formula: C5H8O3S
molecular weight: 148.01941
structure: ChemicalStructure/PW C001195

2.1.1.20
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000185 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000749 Nucleus/Stoichiometry/1.0
right: S-Adenosylmethionine
right: Glycine
spontaneous: false
EC number: 2.1.1.20
left: S-Adenosylhomocysteine
left: Sarcosine
name: S-Adenosylhomocysteine + Sarcosine ↔ Glycine + S-Adenosylmethionine
conversion direction: REVERSIBLE

Reference/UniProt Q9Y3D2
type: UnificationXref
id: Q9Y3D2
db: UniProt

Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
type: Pathway
pathway order: PathwayEnzymeReaction/957
pathway order: PathwayEnzymeReaction/211583
pathway order: PathwaySubPathway/135
pathway order: PathwayEnzymeReaction/989
pathway order: PathwaySubPathway/136
pathway order: PathwaySubPathway/133
pathway order: PathwayEnzymeReaction/947
pathway order: PathwayEnzymeReaction/952
pathway order: PathwayEnzymeReaction/955
pathway order: PathwayEnzymeReaction/211581
pathway order: PathwayEnzymeReaction/998
pathway order: PathwayEnzymeReaction/211582
pathway order: PathwayEnzymeReaction/3365
pathway order: PathwayEnzymeReaction/2515860
pathway order: PathwayEnzymeReaction/1002
pathway order: PathwayEnzymeReaction/1013
pathway order: PathwayEnzymeReaction/1001
pathway order: PathwayEnzymeReaction/1012
pathway order: PathwayEnzymeReaction/1021
pathway order: PathwayEnzymeReaction/1005
pathway order: PathwayEnzymeReaction/1015
pathway order: PathwayEnzymeReaction/1018
pathway order: PathwayEnzymeReaction/1029
pathway component: ReactionCatalysis356
pathway component: ReactionCatalysis774
pathway component: ReactionCatalysis771
pathway component: 4.2.1.22
pathway component: ReactionCatalysis750
pathway component: 2.5.1.16
pathway component: 2.4.2.28
pathway component: 2.1.1.5
pathway component: 4.4.1.1
pathway component: 1.8.4.-
pathway component: ReactionCatalysis408
pathway component: ReactionCatalysis724
pathway component: Reaction795
pathway component: ReactionCatalysis769
pathway component: 2.1.2.1
pathway component: Reaction673
pathway component: 4.1.1.50
pathway component: ReactionCatalysis764
pathway component: Reaction670
pathway component: ReactionCatalysis1520
pathway component: 2.5.1.6
pathway component: Cysteine Metabolism
pathway component: ReactionCatalysis762
pathway component: ReactionCatalysis168
pathway component: ReactionCatalysis166
pathway component: 1.4.3.2
pathway component: ReactionCatalysis321
pathway component: 1.5.1.20
pathway component: 2.1.1.20
pathway component: 6.1.1.10
pathway component: 1.1.99.1
pathway component: Sulfate/Sulfite Metabolism
pathway component: ReactionCatalysis717
pathway component: ReactionCatalysis759
pathway component: ReactionCatalysis2164
pathway component: Glycine and Serine Metabolism
pathway component: ReactionCatalysis776
xref: Reference/PathWhiz PW000104
xref: Reference/SMPDB SMP0000340
organism: Homo sapiens

Reference/HMDB HMDB0000963
type: UnificationXref
id: HMDB0000963
db: HMDB

5-Methyltetrahydrofolic acid
type: SmallMoleculeReference
xref: Reference/BioCyc 5-METHYL-THF
xref: Reference/ChEBI CHEBI 15641
xref: Reference/PubChem-compound 439234
xref: Reference/CAS 134-35-0
xref: Reference/KEGG Compound C00440
xref: Reference/ChemSpider 388371
xref: Reference/HMDB HMDB0001396
chemical formula: C20H25N7O6
molecular weight: 459.18665
structure: ChemicalStructure/PW C001079

Reference/ChEBI CHEBI 15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ReactionCatalysis2164
type: Catalysis
controller: Methionine-R-sulfoxide reductase B2, mitochondrial
controlled: 1.8.4.-
control type: ACTIVATION

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

ReactionCatalysis356
type: Catalysis
controller: Cystathionine beta-synthase
controlled: 4.2.1.22
control type: ACTIVATION

Spermidine synthase
type: Protein
cellular location: Cytosol
entity reference: Spermidine synthase

Reference/ChEBI CHEBI 16335
type: UnificationXref
id: CHEBI:16335
db: ChEBI

Compound/PW C001783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Betaine--homocysteine S-methyltransferase 1
type: Complex
component stoichiometry: Protein/530 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Betaine--homocysteine S-methyltransferase 1

Reference/ChemSpider 388392
type: UnificationXref
id: 388392
db: ChemSpider

S-adenosylmethionine decarboxylase proenzyme
type: Protein
cellular location: Cytosol
entity reference: S-adenosylmethionine decarboxylase proenzyme

L-Methionine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Methionine

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/BioCyc L-METHIONINE SULFOXIDE
type: UnificationXref
id: L-METHIONINE_SULFOXIDE
db: BioCyc

ChemicalStructure/PW C000770
type: ChemicalStructure
structure format: SMILES
structure data: CSCC1OC(OP(O)(O)=O)[C@H](O)[C@@H]1O

Reference/PubChem-compound 439234
type: UnificationXref
id: 439234
db: PubChem-compound

Reference/HMDB HMDB0000972
type: UnificationXref
id: HMDB0000972
db: HMDB

Reference/ChemSpider 299
type: UnificationXref
id: 299
db: ChemSpider

ChemicalStructure/PW C000774
type: ChemicalStructure
structure format: SMILES

5'-Methylthioadenosine
type: SmallMolecule
cellular location: Cytosol
entity reference: 5'-Methylthioadenosine

Methylenetetrahydrofolate reductase
type: ProteinReference
xref: Reference/UniProt P42898
organism: Homo sapiens

Reaction795
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001221 Cytosol/Stoichiometry/1.0
participant stoichiometry: RNA/17 Cytosol/Stoichiometry/1.0
participant stoichiometry: RNA/18 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000774 Cytosol/Stoichiometry/1.0
right: Tetrahydrofolic acid
right: N-formylmethionyl-tRNA(fMet)
spontaneous: false
left: L-Methionyl-tRNA(Met)
left: 10-Formyltetrahydrofolate
name: 10-Formyltetrahydrofolate + L-Methionyl-tRNA(Met) → N-formylmethionyl-tRNA(fMet) + Tetrahydrofolic acid
conversion direction: LEFT_TO_RIGHT

Reference/PathWhiz PW000018
type: UnificationXref
id: PW000018
db: PathWhiz

L-Serine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Serine

Reaction673
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000749 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000590 Cytosol/Stoichiometry/1.0
right: Adenosine
right: Homocysteine
spontaneous: false
left: S-Adenosylhomocysteine
left: Water
name: S-Adenosylhomocysteine + Water → Adenosine + Homocysteine
conversion direction: LEFT_TO_RIGHT

Reaction670
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000548 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001221 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001079 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000590 Cytosol/Stoichiometry/1.0
right: Tetrahydrofolic acid
right: L-Methionine
spontaneous: false
left: 5-Methyltetrahydrofolic acid
left: Homocysteine
name: 5-Methyltetrahydrofolic acid + Homocysteine → L-Methionine + Tetrahydrofolic acid
conversion direction: LEFT_TO_RIGHT

2.5.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000548 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000921 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Pyrophosphate
right: S-Adenosylmethionine
spontaneous: false
EC number: 2.5.1.6
left: Adenosine triphosphate
left: L-Methionine
left: Water
name: Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc ADENOSINE
type: UnificationXref
id: ADENOSINE
db: BioCyc

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

L-Cysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Cysteine
name: SubPathwayOutput

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

5'-Methylthioadenosine
type: SmallMoleculeReference
xref: Reference/CAS 2457-80-9
xref: Reference/PubChem-compound 439176
xref: Reference/KEGG Compound C00170
xref: Reference/ChEBI CHEBI 17509
xref: Reference/HMDB HMDB0001173
xref: Reference/BioCyc 5-METHYLTHIOADENOSINE
xref: Reference/ChemSpider 388321
chemical formula: C11H15N5O3S
molecular weight: 297.08957
structure: ChemicalStructure/PW C000910

Reference/CAS 56-45-1
type: UnificationXref
id: 56-45-1
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 1045
type: UnificationXref
id: 1045
db: PubChem-compound

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Oxygen
type: SmallMolecule
cellular location: Cytosol
entity reference: Oxygen

Reference/CAS 62697-73-8
type: UnificationXref
id: 62697-73-8
db: CAS

Choline dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q8NE62
organism: Homo sapiens

Serine hydroxymethyltransferase, cytosolic
type: Complex
component stoichiometry: Protein/739 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Serine hydroxymethyltransferase, cytosolic

Reference/HMDB HMDB0000742
type: UnificationXref
id: HMDB0000742
db: HMDB

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

ChemicalStructure/PW C000783
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q13126
type: UnificationXref
id: Q13126
db: UniProt

Reference/UniProt Q9NZL9
type: UnificationXref
id: Q9NZL9
db: UniProt

Reference/PubChem-compound 25243997
type: UnificationXref
id: 25243997
db: PubChem-compound

Reference/HMDB HMDB0000988
type: UnificationXref
id: HMDB0000988
db: HMDB

Compound/PW C001079 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Methyltetrahydrofolic acid
stoichiometric coefficient: 1.0

Compound/PW C000910 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5'-Methylthioadenosine
stoichiometric coefficient: 1.0

Reference/ChemSpider 388371
type: UnificationXref
id: 388371
db: ChemSpider

ChemicalStructure/PW C000749
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc HOMO-SER
type: UnificationXref
id: HOMO-SER
db: BioCyc

Spermidine
type: SmallMolecule
cellular location: Cytosol
entity reference: Spermidine

tRNA(Met)
type: RnaReference
xref: Reference/ChEBI CHEBI 29173
organism: Homo sapiens

Reference/SMPDB SMP0000340
type: UnificationXref
id: SMP0000340
db: SMPDB

Sarcosine
type: SmallMolecule
cellular location: Nucleus
entity reference: Sarcosine

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/ChEBI CHEBI 15354
type: UnificationXref
id: CHEBI:15354
db: ChEBI

Reference/ChemSpider 109092
type: UnificationXref
id: 109092
db: ChemSpider

Methylenetetrahydrofolate reductase
type: Complex
component stoichiometry: Protein/183 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Methylenetetrahydrofolate reductase

Methionine-R-sulfoxide reductase B3
type: ProteinReference
xref: Reference/UniProt Q8IXL7
organism: Homo sapiens

Reference/HMDB HMDB0001846
type: UnificationXref
id: HMDB0001846
db: HMDB

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/ChEBI CHEBI 16680
type: UnificationXref
id: CHEBI:16680
db: ChEBI

S-methyl-5'-thioadenosine phosphorylase
type: Protein
cellular location: Cytosol
entity reference: S-methyl-5'-thioadenosine phosphorylase

Methionine-R-sulfoxide reductase B2, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9Y3D2
organism: Homo sapiens

Reference/PubChem-compound 24762165
type: UnificationXref
id: 24762165
db: PubChem-compound

reduced thioredoxin
type: SmallMolecule
cellular location: Mitochondrion
entity reference: reduced thioredoxin

Reference/PubChem-compound 13781857
type: UnificationXref
id: 13781857
db: PubChem-compound

Compound/PW C000783 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-Adenosylmethioninamine
stoichiometric coefficient: 1.0