1.0
Guanosine diphosphate
Myosin light chain kinase, smooth muscle
Guanine nucleotide-binding protein G(T) subunit gamma-T1
Gβ
cAMP-dependent protein kinase catalytic subunit beta
CPD-8587
BioCyc
cAMP
SubPathwayInput
P08590
UniProt
C00035
KEGG Compound
1.0
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Reaction596
false
Adenosine triphosphate → Pyrophosphate + cAMP
LEFT_TO_RIGHT
HMDB0000250
HMDB
1.0
SMILES
OP(O)(=O)OP(O)(O)=O
14000-31-8
CAS
Guanine nucleotide-binding protein G(T) subunit gamma-T1
PW000452
PathWhiz
1.0
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
HMDB0000538
HMDB
C00044
KEGG Compound
SMILES
CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2OC(C[C@H]12)=CCCCC(O)=O
ATP
BioCyc
P63092
UniProt
5282411
PubChem-compound
559142
ChemSpider
Q15746
UniProt
Guanine nucleotide-binding protein gamma-beta
C10H12N5O6P
cAMP
329.05252
1.0
SubPathwayInteraction697
SubPathwayReaction
SubPathway697Reaction
SubPathwayInteraction695
SubPathway695Reaction
SubPathwayReaction
CHEBI:15422
ChEBI
SubPathwayInteraction696
SubPathwayReaction
SubPathway696Reaction
Reaction1958
false
Adenylate cyclase type 2 + Guanine nucleotide-binding protein alpha → Adenylate cyclase type 2 + Guanine nucleotide-binding protein alpha
LEFT_TO_RIGHT
Q08462
UniProt
Homo sapiens
5742
ChemSpider
C00575
KEGG Compound
GO:0005829
GENE ONTOLOGY
Prostaglandin I2
TransportCatalysis178
ACTIVATION
CHEBI:15552
ChEBI
1.0
C10H16N5O13P3
Adenosine triphosphate
506.99576
Pyrophosphate
H3O4P
Phosphate
97.9769
Prostacyclin receptor
5851
ChemSpider
8977
PubChem-compound
6830
PubChem-compound
C01312
KEGG Compound
C10H15N5O11P2
Guanosine diphosphate
443.02432
Myosin light chain kinase, smooth muscle
SubPathwayInput
ReactionCatalysis1995
ACTIVATION
SMILES
[H][C@@]12COP(O)(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)N1C=NC2=C1N=CN=C2N
ReactionCatalysis1996
ACTIVATION
5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
BioCyc
ReactionCatalysis1998
ACTIVATION
PPI
BioCyc
P43119
UniProt
1.0
Prostacyclin receptor
1.0
9606
TAXONOMY
4445566
ChemSpider
C10H16N5O14P3
Guanosine triphosphate
522.99066
1.0
Guanosine triphosphate
P62873
UniProt
Cytosol
Adenylate cyclase type 2
8630
ChemSpider
1.0
1.0
Guanine nucleotide-binding protein alpha-beta-gamma
HMDB0000058
HMDB
SMILES
OP(O)(O)=O
GO:0005886
GENE ONTOLOGY
2.7.11.11
false
2.7.11.11
cAMP → cAMP + cAMP-dependent protein kinase catalytic subunit beta
LEFT_TO_RIGHT
Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
C00009
KEGG Compound
Cell Membrane
1.0
14265-44-2
CAS
6569
ChemSpider
HMDB0001429
HMDB
P22694
UniProt
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
CHEBI:18361
ChEBI
CHEBI:17552
ChEBI
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
CHEBI:18367
ChEBI
P63211
UniProt
GTP
BioCyc
1032
ChemSpider
C00002
KEGG Compound
Phosphate
2.7.11.18
false
2.7.11.18
Myosin light chain 3 → Myosin light chain 3 + Phosphate
LEFT_TO_RIGHT
Reaction2131
false
Guanosine triphosphate + Prostacyclin receptor → Guanine nucleotide-binding protein alpha + Guanine nucleotide-binding protein gamma-beta + Guanosine diphosphate + Prostacyclin receptor
LEFT_TO_RIGHT
2.7.11.11
false
2.7.11.11
Myosin light chain kinase, smooth muscle → Myosin light chain kinase, smooth muscle + Phosphate
LEFT_TO_RIGHT
Myosin light chain 3
SubPathwayOutput
GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
BioCyc
Adenylate cyclase type 2
1.0
HMDB0001273
HMDB
CHEBI:17489
ChEBI
644102
PubChem-compound
CAMP
BioCyc
ReactionCatalysis1816
ACTIVATION
cAMP-dependent protein kinase catalytic subunit beta
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
1.0
Extracellular Space
C00013
KEGG Compound
HMDB0001201
HMDB
H4O7P2
Pyrophosphate
177.94322
Myosin light chain 3
5957
PubChem-compound
Muscle/Heart Contraction
SubPathway
Vasodilation
SubPathway
Transport213
false
Prostaglandin I2 (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
Platelet Aggregation
SubPathway
86-01-1
CAS
1.0
35121-78-9
CAS
1061
PubChem-compound
6076
PubChem-compound
CHEBI:15996
ChEBI
Gβ
C20H32O5
Prostaglandin I2
352.22498
56-65-5
CAS
1.0
Prostacyclin receptor
HMDB0001335
HMDB
Prostaglandin I2
Adenosine triphosphate
GO:0005615
GENE ONTOLOGY
1.0
146-91-8
CAS
60-92-4
CAS
SMP0000354
SMPDB