Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Cytochrome b-c1 complex subunit 1, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome b-c1 complex subunit 1, mitochondrial

Reference/UniProt P06576
type: UnificationXref
id: P06576
db: UniProt

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 439162
type: UnificationXref
id: 439162
db: PubChem-compound

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt P31040
organism: Homo sapiens

ATP synthase subunit beta, mitochondrial
type: Protein
entity reference: ATP synthase subunit beta, mitochondrial

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/CAS 110-17-8
type: UnificationXref
id: 110-17-8
db: CAS

Reference/HMDB HMDB0001060
type: UnificationXref
id: HMDB0001060
db: HMDB

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Ubiquinol-8
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 61682
xref: Reference/PubChem-compound 22833558
xref: Reference/CAS 74075-00-6
xref: Reference/BioCyc CPD-9956
xref: Reference/ChemSpider 24603698
xref: Reference/HMDB HMDB0001060
chemical formula: C49H76O4
molecular weight: 728.57434
structure: ChemicalStructure/PW C000835

NAD
type: SmallMolecule
entity reference: NAD

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Coenzyme Q10
type: SmallMolecule
entity reference: Coenzyme Q10

Reference/UniProt P10606
type: UnificationXref
id: P10606
db: UniProt

Protein/116 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
stoichiometric coefficient: 1.0

ATP synthase subunit epsilon, mitochondrial
type: Protein
entity reference: ATP synthase subunit epsilon, mitochondrial

ATP synthase subunit gamma, mitochondrial
type: Protein
entity reference: ATP synthase subunit gamma, mitochondrial

Reference/HMDB HMDB0001072
type: UnificationXref
id: HMDB0001072
db: HMDB

Ubiquinol-8
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Ubiquinol-8

Reference/PathWhiz PW000165
type: UnificationXref
id: PW000165
db: PathWhiz

Cytochrome c1, heme protein, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c1, heme protein, mitochondrial

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

NADH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADH

Ubiquinol-8
type: SmallMolecule
entity reference: Ubiquinol-8

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5281915
type: UnificationXref
id: 5281915
db: PubChem-compound

Reference/ChemSpider 709
type: UnificationXref
id: 709
db: ChemSpider

Reference/UniProt Q06055
type: UnificationXref
id: Q06055
db: UniProt

Reference/PathWhiz PW000152
type: UnificationXref
id: PW000152
db: PathWhiz

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Cytochrome c oxidase complex IV
type: Complex
cellular location: Mitochondrial Inner Membrane
component: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
component: Cytochrome c oxidase subunit 7A2, mitochondrial
component: Cytochrome c oxidase subunit 6A2, mitochondrial
component: Cytochrome c oxidase subunit 7B, mitochondrial
component: Cytochrome c oxidase subunit 8A, mitochondrial
component: Cytochrome c oxidase subunit 5B, mitochondrial
component: Cytochrome c oxidase subunit 3
component: Cytochrome c oxidase subunit 6C
component: Cytochrome c oxidase subunit 6B2
component: Cytochrome c oxidase subunit 2
component: Cytochrome c oxidase subunit NDUFA4
component: Cytochrome c oxidase subunit 7C, mitochondrial
component: Cytochrome c oxidase subunit 1
component: Cytochrome c oxidase subunit 5A, mitochondrial

Reference/UniProt O43826
type: UnificationXref
id: O43826
db: UniProt

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt O14521
organism: Homo sapiens

D-Glyceraldehyde 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GAP
xref: Reference/ChEBI CHEBI 17138
xref: Reference/HMDB HMDB0001112
xref: Reference/ChemSpider 709
xref: Reference/KEGG Compound C00661
xref: Reference/PubChem-compound 729
xref: Reference/CAS 591-59-3
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C000869

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q6YFQ2
type: UnificationXref
id: Q6YFQ2
db: UniProt

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Protein/145 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
stoichiometric coefficient: 1.0

Glyceric acid 1,3-biphosphate
type: SmallMoleculeReference
xref: Reference/CAS 1981-49-3
xref: Reference/ChemSpider 663
xref: Reference/BioCyc DPG
xref: Reference/HMDB HMDB0001270
xref: Reference/KEGG Compound C00236
xref: Reference/PubChem-compound 683
chemical formula: C3H8O10P2
molecular weight: 265.95926
structure: ChemicalStructure/PW C000983

Reference/KEGG Compound C00111
type: UnificationXref
id: C00111
db: KEGG Compound

ADP/ATP translocase 1
type: Protein
entity reference: ADP/ATP translocase 1

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00236
type: UnificationXref
id: C00236
db: KEGG Compound

Compound/PW C001144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/BioCyc SUC
type: UnificationXref
id: SUC
db: BioCyc

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Glyceraldehyde-3-phosphate dehydrogenase
type: Protein
cellular location: Cytosol
entity reference: Glyceraldehyde-3-phosphate dehydrogenase

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Succinate dehydrogenase
type: Complex
component stoichiometry: Protein/116 Mitochondrial Inner Membrane/Stoichiometry/1.0
component stoichiometry: Protein/145 Mitochondrial Inner Membrane/Stoichiometry/1.0
component stoichiometry: Protein/174 Mitochondrial Inner Membrane/Stoichiometry/1.0
component stoichiometry: Protein/188 Mitochondrial Inner Membrane/Stoichiometry/1.0
cellular location: Mitochondrial Inner Membrane
component: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
component: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Reference/KEGG Compound C00122
type: UnificationXref
id: C00122
db: KEGG Compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q99643
organism: Homo sapiens

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/UniProt P13073
type: UnificationXref
id: P13073
db: UniProt

Mitochondrial Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005743

Reference/KEGG Compound C11378
type: UnificationXref
id: C11378
db: KEGG Compound

Compound/PW C000835 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquinol-8
stoichiometric coefficient: 1.0

Coenzyme Q10
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001072
xref: Reference/BioCyc UBIQUINONE-10
xref: Reference/PubChem-compound 5281915
xref: Reference/ChemSpider 4445197
xref: Reference/CAS 303-98-0
xref: Reference/KEGG Compound C11378
xref: Reference/ChEBI CHEBI 46245
chemical formula: C59H90O4
molecular weight: 862.6839
structure: ChemicalStructure/PW C000846

Reference/CAS 74075-00-6
type: UnificationXref
id: 74075-00-6
db: CAS

Compound/PW C000835 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquinol-8
stoichiometric coefficient: 1.0

Cytochrome c oxidase subunit 7B, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c oxidase subunit 7B, mitochondrial

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Oxygen
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Oxygen

Compound/PW C000174 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinic acid
stoichiometric coefficient: 1.0

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
type: ProteinReference
xref: Reference/UniProt O15239

Reaction2164
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000983 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000869 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
right: Phosphate
right: NADH
right: Glyceric acid 1,3-biphosphate
spontaneous: false
left: NAD
left: D-Glyceraldehyde 3-phosphate
name: D-Glyceraldehyde 3-phosphate + NAD → Glyceric acid 1,3-biphosphate + NADH + Phosphate
conversion direction: LEFT_TO_RIGHT

1.3.5.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000174 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000835 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000088 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000846 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: Ubiquinol-8
right: Fumaric acid
spontaneous: false
EC number: 1.3.5.1
left: Coenzyme Q10
left: Succinic acid
name: Coenzyme Q10 + Succinic acid → Fumaric acid + Ubiquinol-8
conversion direction: LEFT_TO_RIGHT

1.1.5.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000835 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000081 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001134 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000846 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: Ubiquinol-8
right: Dihydroxyacetone phosphate
spontaneous: false
EC number: 1.1.5.3
left: Coenzyme Q10
left: Glycerol 3-phosphate
name: Coenzyme Q10 + Glycerol 3-phosphate → Dihydroxyacetone phosphate + Ubiquinol-8
conversion direction: LEFT_TO_RIGHT

Reference/UniProt O00483
type: UnificationXref
id: O00483
db: UniProt

Reference/ChEBI CHEBI 17138
type: UnificationXref
id: CHEBI:17138
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/ChemSpider 388308
type: UnificationXref
id: 388308
db: ChemSpider

Phosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Phosphate

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Fumaric acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Fumaric acid
name: SubPathwayInput

ATP synthase subunit delta, mitochondrial
type: Protein
entity reference: ATP synthase subunit delta, mitochondrial

Reference/UniProt O14521
type: UnificationXref
id: O14521
db: UniProt

ATP synthase subunit a
type: Protein
entity reference: ATP synthase subunit a

Cytochrome c oxidase subunit NDUFA4
type: ProteinReference
xref: Reference/UniProt O00483
organism: Homo sapiens

ATP synthase lipid-binding protein, mitochondrial
type: Protein
entity reference: ATP synthase lipid-binding protein, mitochondrial

Ubiquinol-8
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Ubiquinol-8

Reference/UniProt P31930
type: UnificationXref
id: P31930
db: UniProt

Compound/PW C000835/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquinol-8
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000134
type: UnificationXref
id: HMDB0000134
db: HMDB

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000254
type: UnificationXref
id: HMDB0000254
db: HMDB

ChemicalStructure/PW C000174
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)CCC(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Protein/659 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glyceraldehyde-3-phosphate dehydrogenase
stoichiometric coefficient: 4.0

Cytochrome c oxidase subunit 6A2, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c oxidase subunit 6A2, mitochondrial

Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 4445197
type: UnificationXref
id: 4445197
db: ChemSpider

Reference/KEGG Compound C00042
type: UnificationXref
id: C00042
db: KEGG Compound

Reference/ChemSpider 648
type: UnificationXref
id: 648
db: ChemSpider

Reference/CAS 303-98-0
type: UnificationXref
id: 303-98-0
db: CAS

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001112
type: UnificationXref
id: HMDB0001112
db: HMDB

Cytochrome c oxidase subunit 6B2
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c oxidase subunit 6B2

Compound/PW C040034 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001473
type: UnificationXref
id: HMDB0001473
db: HMDB

Reference/ChemSpider 10197150
type: UnificationXref
id: 10197150
db: ChemSpider

Reaction814
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000081 Cytosol/Stoichiometry/1.0
right: NAD
right: Glycerol 3-phosphate
spontaneous: false
left: Dihydroxyacetone phosphate
left: NADH
name: Dihydroxyacetone phosphate + NADH → Glycerol 3-phosphate + NAD
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 668
type: UnificationXref
id: 668
db: PubChem-compound

Coenzyme Q10
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Coenzyme Q10

Reference/BioCyc FUM
type: UnificationXref
id: FUM
db: BioCyc

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Adenosine diphosphate

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChEBI CHEBI 18012
type: UnificationXref
id: CHEBI:18012
db: ChEBI

Reference/CAS 591-59-3
type: UnificationXref
id: 591-59-3
db: CAS

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Reference/PubChem-compound 22833558
type: UnificationXref
id: 22833558
db: PubChem-compound

Cytochrome b-c1 complex subunit Rieske, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome b-c1 complex subunit Rieske, mitochondrial

Reference/UniProt P21912
type: UnificationXref
id: P21912
db: UniProt

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

NAD
type: SmallMolecule
cellular location: Cytosol
entity reference: NAD

Cytochrome b-c1 complex subunit 8
type: ProteinReference
xref: Reference/UniProt O14949
organism: Homo sapiens

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/BioCyc DPG
type: UnificationXref
id: DPG
db: BioCyc

Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
type: UnificationXref
id: DIHYDROXY-ACETONE-PHOSPHATE
db: BioCyc

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/ChemSpider 663
type: UnificationXref
id: 663
db: ChemSpider

ChemicalStructure/PW C001134
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)COP(O)(O)=O

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Adenosine triphosphate

Compound/PW C001065 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Cytochrome c oxidase subunit 7A2, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c oxidase subunit 7A2, mitochondrial

Reference/UniProt P00395
type: UnificationXref
id: P00395
db: UniProt

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

ReactionCoupledTransport41
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C000721/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000846/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000835/Stoichiometry/1.0
right: Hydrogen Ion
right: NAD
right: Ubiquinol-8
spontaneous: false
left: NADH
left: Hydrogen Ion
left: Coenzyme Q10
name: Coenzyme Q10 + Hydrogen Ion + NADH → Hydrogen Ion + NAD + Ubiquinol-8
conversion direction: LEFT_TO_RIGHT

ReactionCoupledTransport516
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C000835 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/1587 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000846 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: Coenzyme Q10
right: Hydrogen Ion
right: Cytochrome c
spontaneous: false
left: Ubiquinol-8
left: Hydrogen Ion
left: Cytochrome c
name: Cytochrome c + Hydrogen Ion + Ubiquinol-8 → Coenzyme Q10 + Cytochrome c + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

ReactionCoupledTransport40
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Hydrogen Ion
right: Adenosine triphosphate
spontaneous: false
left: Adenosine diphosphate
left: Hydrogen Ion
name: Adenosine diphosphate + Hydrogen Ion → Adenosine triphosphate + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Reference/UniProt O14957
type: UnificationXref
id: O14957
db: UniProt

1.9.3.1
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Inner Membrane/Stoichiometry/2.0
participant stoichiometry: Protein/1587 Mitochondrial Inner Membrane/Stoichiometry/2.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Inner Membrane/Stoichiometry/4.0
participant stoichiometry: Compound/PW C001065 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: Hydrogen Ion
right: Water
right: Cytochrome c
spontaneous: false
EC number: 1.9.3.1
left: Hydrogen Ion
left: Cytochrome c
left: Oxygen
name: 2 Cytochrome c + 4 Hydrogen Ion + 4 Hydrogen Ion + Oxygen → 2 Cytochrome c + 4 Hydrogen Ion + 2 Water
conversion direction: LEFT_TO_RIGHT

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Hydrogen Ion

Reference/UniProt P00156
type: UnificationXref
id: P00156
db: UniProt

Reference/PubChem-compound 729
type: UnificationXref
id: 729
db: PubChem-compound

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine diphosphate

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Protein/1587 Mitochondrial Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Cytochrome c
stoichiometric coefficient: 2.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Reference/BioCyc GLYCEROL-3P
type: UnificationXref
id: GLYCEROL-3P
db: BioCyc

Reference/UniProt P07919
type: UnificationXref
id: P07919
db: UniProt

Cytochrome c oxidase subunit NDUFA4
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c oxidase subunit NDUFA4

Reference/KEGG Compound C00093
type: UnificationXref
id: C00093
db: KEGG Compound

Reference/HMDB HMDB0001270
type: UnificationXref
id: HMDB0001270
db: HMDB

Reference/UniProt P04406
type: UnificationXref
id: P04406
db: UniProt

Reference/UniProt O14949
type: UnificationXref
id: O14949
db: UniProt

Cytochrome c oxidase subunit 5A, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c oxidase subunit 5A, mitochondrial

Compound/PW C000869 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glyceraldehyde 3-phosphate
stoichiometric coefficient: 1.0

Succinic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Succinic acid
name: SubPathwayOutput

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Transport217
type: Transport
participant stoichiometry: Compound/PW C001034 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
spontaneous: false
left: Adenosine diphosphate
name: Adenosine diphosphate (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Outer Membrane
conversion direction: LEFT_TO_RIGHT

Transport216
type: Transport
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Adenosine triphosphate
spontaneous: false
left: Adenosine triphosphate
name: Adenosine triphosphate (→) Transport: Homo sapiens, Cell, Mitochondrial Outer Membrane to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Succinic acid
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Succinic acid

Transport219
type: Transport
participant stoichiometry: Compound/PW C000081 Mitochondrial Intermembrane Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000081 Cytosol/Stoichiometry/1.0
right: Glycerol 3-phosphate
spontaneous: false
left: Glycerol 3-phosphate
name: Glycerol 3-phosphate (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport218
type: Transport
participant stoichiometry: Compound/PW C001034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Adenosine triphosphate
right: Adenosine diphosphate
spontaneous: false
left: Adenosine diphosphate
left: Adenosine triphosphate
name: Adenosine diphosphate (→), Adenosine triphosphate (←) Transport: Homo sapiens, Cell, Mitochondrial Outer Membrane to Homo sapiens, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Transport215
type: Transport
participant stoichiometry: Compound/PW C001104 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Mitochondrial Matrix/Stoichiometry/1.0
right: Phosphate
spontaneous: false
left: Phosphate
name: Phosphate (→) Transport: Homo sapiens, Cell, Mitochondrial Outer Membrane to Homo sapiens, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

Transport214
type: Transport
participant stoichiometry: Compound/PW C001104 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
spontaneous: false
left: Phosphate
name: Phosphate (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Outer Membrane
conversion direction: LEFT_TO_RIGHT

Transport220
type: Transport
participant stoichiometry: Compound/PW C001134 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001134 Mitochondrial Intermembrane Space/Stoichiometry/1.0
right: Dihydroxyacetone phosphate
spontaneous: false
left: Dihydroxyacetone phosphate
name: Dihydroxyacetone phosphate (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Glucose-6-phosphate translocase
type: ProteinReference
xref: Reference/UniProt O43826

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Protein/1587 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytochrome c
stoichiometric coefficient: 1.0

Glyceraldehyde-3-phosphate dehydrogenase
type: ProteinReference
xref: Reference/UniProt P04406
organism: Homo sapiens

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000088
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)\C=C\C(O)=O

Reference/UniProt Q99643
type: UnificationXref
id: Q99643
db: UniProt

Phosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Phosphate

Cytochrome c oxidase subunit 7C, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c oxidase subunit 7C, mitochondrial

ChemicalStructure/PW C000081
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@@H](O)COP(O)(O)=O

Compound/PW C001420 Mitochondrial Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Compound/PW C001134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroxyacetone phosphate
stoichiometric coefficient: 1.0

ATP synthase subunit b, mitochondrial
type: ProteinReference
xref: Reference/UniProt P24539

Reference/BioCyc CPD-9956
type: UnificationXref
id: CPD-9956
db: BioCyc

Cytochrome b-c1 complex subunit 2, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome b-c1 complex subunit 2, mitochondrial

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine triphosphate

NADH
type: SmallMolecule
entity reference: NADH

Glyceraldehyde-3-phosphate dehydrogenase
type: Complex
component stoichiometry: Protein/659 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Glyceraldehyde-3-phosphate dehydrogenase

Compound/PW C000983 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyceric acid 1,3-biphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 21883788
type: UnificationXref
id: 21883788
db: PubChem-compound

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Cytochrome c
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c

Reference/UniProt P36542
type: UnificationXref
id: P36542
db: UniProt

Glycerol 3-phosphate
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Glycerol 3-phosphate

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/UniProt P24311
type: UnificationXref
id: P24311
db: UniProt

Reference/UniProt P14406
type: UnificationXref
id: P14406
db: UniProt

Reference/CAS 1981-49-3
type: UnificationXref
id: 1981-49-3
db: CAS

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Dihydroxyacetone phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
xref: Reference/PubChem-compound 668
xref: Reference/ChEBI CHEBI 16108
xref: Reference/KEGG Compound C00111
xref: Reference/CAS 57-04-5
xref: Reference/ChemSpider 648
xref: Reference/HMDB HMDB0001473
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C001134

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/ChEBI CHEBI 46245
type: UnificationXref
id: CHEBI:46245
db: ChEBI

Cytochrome c oxidase subunit 6B2
type: ProteinReference
xref: Reference/UniProt Q6YFQ2
organism: Homo sapiens

SubPathwayInteraction734
type: Interaction
name: SubPathwayReaction
name: SubPathway734Reaction
participant: Fumaric acid

SubPathwayInteraction735
type: Interaction
name: SubPathway735Reaction
name: SubPathwayReaction
participant: D-Glyceraldehyde 3-phosphate

Reference/UniProt P12235
type: UnificationXref
id: P12235
db: UniProt

SubPathwayInteraction733
type: Interaction
name: SubPathwayReaction
name: SubPathway733Reaction
participant: Succinic acid

SubPathwayInteraction736
type: Interaction
name: SubPathwayReaction
name: SubPathway736Reaction
participant: Glyceric acid 1,3-biphosphate

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Cytochrome c oxidase subunit 3
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c oxidase subunit 3

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
type: Protein
entity reference: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

Reference/UniProt P10176
type: UnificationXref
id: P10176
db: UniProt

Cytochrome c oxidase subunit 1
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c oxidase subunit 1

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Citric Acid Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway733
pathway order: SubPathwayInteractionSteps/SubPathway734
pathway component: SubPathwayInteraction734
pathway component: SubPathwayInteraction733
xref: Reference/PathWhiz PW000005
xref: Reference/SMPDB SMP0000057
name: SubPathway

Compound/PW C001034 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Cytochrome c
type: ProteinReference
xref: Reference/UniProt P99999
organism: Homo sapiens

Cytochrome c oxidase subunit 8A, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c oxidase subunit 8A, mitochondrial

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

ATP synthase subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt P25705

Reference/UniProt P56381
type: UnificationXref
id: P56381
db: UniProt

Protein/924 Mitochondrial Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Cytochrome b-c1 complex subunit 9
stoichiometric coefficient: 2.0

Cytochrome c oxidase subunit 7A2, mitochondrial
type: ProteinReference
xref: Reference/UniProt P14406
organism: Homo sapiens

Cytochrome c oxidase subunit 8A, mitochondrial
type: ProteinReference
xref: Reference/UniProt P10176
organism: Homo sapiens

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Reference/PubChem-compound 683
type: UnificationXref
id: 683
db: PubChem-compound

Compound/PW C000846 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme Q10
stoichiometric coefficient: 1.0

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Cytochrome c oxidase subunit 6C
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c oxidase subunit 6C

Reference/UniProt Q9UDW1
type: UnificationXref
id: Q9UDW1
db: UniProt

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Mitochondrial Electron Transport Chain
type: Pathway
pathway order: PathwayEnzymeReaction/211594
pathway order: PathwayEnzymeReaction/211595
pathway order: PathwayEnzymeReaction/211596
pathway order: PathwayEnzymeReaction/211597
pathway order: PathwayTransport/1248850
pathway order: PathwayEnzymeReaction/211593
pathway order: PathwaySubPathway/735
pathway order: PathwaySubPathway/736
pathway order: PathwaySubPathway/733
pathway order: PathwaySubPathway/734
pathway order: PathwayEnzymeReaction/2933
pathway order: PathwayEnzymeReaction/2935
pathway order: PathwayTransport/2923
pathway order: PathwayTransport/2924
pathway order: PathwayTransport/2921
pathway order: PathwayTransport/2922
pathway order: PathwayEnzymeReaction/211602
pathway order: PathwayEnzymeReaction/2520690
pathway order: PathwayEnzymeReaction/211600
pathway order: PathwayEnzymeReaction/211601
pathway order: PathwayEnzymeReaction/2520689
pathway order: PathwayEnzymeReaction/2941
pathway order: PathwayTransport/2938
pathway order: PathwayTransport/2939
pathway order: PathwayEnzymeReaction/211598
pathway order: PathwayEnzymeReaction/211599
pathway component: Reaction814
pathway component: TransportCatalysis180
pathway component: ReactionCoupledTransport41
pathway component: ReactionCoupledTransport516
pathway component: ReactionCoupledTransport40
pathway component: Reaction2164
pathway component: 1.3.5.1
pathway component: 1.9.3.1
pathway component: 1.1.5.3
pathway component: Transport217
pathway component: Transport216
pathway component: Transport219
pathway component: Transport218
pathway component: TransportCatalysis179
pathway component: Transport215
pathway component: Transport214
pathway component: Citric Acid Cycle
pathway component: Transport220
pathway component: ReactionCoupledTransportCatalysis563
pathway component: ReactionCoupledTransportCatalysis560
pathway component: ReactionCatalysis2005
pathway component: ReactionCoupledTransportCatalysis41
pathway component: ReactionCoupledTransportCatalysis40
pathway component: ReactionCoupledTransportCatalysis47
pathway component: ReactionCoupledTransportCatalysis46
pathway component: Gluconeogenesis
pathway component: ReactionCoupledTransportCatalysis48
pathway component: ReactionCatalysis2002
pathway component: ReactionCoupledTransportCatalysis43
pathway component: ReactionCoupledTransportCatalysis42
pathway component: ReactionCoupledTransportCatalysis45
pathway component: ReactionCatalysis2003
pathway component: ReactionCoupledTransportCatalysis44
xref: Reference/PathWhiz PW000165
xref: Reference/SMPDB SMP0000355
organism: Homo sapiens

Compound/PW C000088 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fumaric acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Cytochrome c oxidase subunit 6C
type: ProteinReference
xref: Reference/UniProt P09669
organism: Homo sapiens

Compound/PW C000721 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

ATP synthase subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt P06576

Glycerol 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GLYCEROL-3P
xref: Reference/HMDB HMDB0000126
xref: Reference/ChemSpider 388308
xref: Reference/CAS 17989-41-2
xref: Reference/KEGG Compound C00093
xref: Reference/ChEBI CHEBI 15978
xref: Reference/PubChem-compound 439162
chemical formula: C3H9O6P
molecular weight: 172.01367
structure: ChemicalStructure/PW C000081

Reference/GENE ONTOLOGY GO 0005758
type: UnificationXref
id: GO:0005758
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Reference/UniProt P22695
type: UnificationXref
id: P22695
db: UniProt

Gluconeogenesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway736
pathway order: SubPathwayInteractionSteps/SubPathway735
pathway component: SubPathwayInteraction735
pathway component: SubPathwayInteraction736
xref: Reference/SMPDB SMP0000128
xref: Reference/PathWhiz PW000152
name: SubPathway

Fumaric acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000134
xref: Reference/ChemSpider 10197150
xref: Reference/CAS 110-17-8
xref: Reference/PubChem-compound 21883788
xref: Reference/KEGG Compound C00122
xref: Reference/BioCyc FUM
xref: Reference/ChEBI CHEBI 18012
chemical formula: C4H4O4
molecular weight: 116.010956
structure: ChemicalStructure/PW C000088

Reference/SMPDB SMP0000057
type: UnificationXref
id: SMP0000057
db: SMPDB

Reference/CAS 57-04-5
type: UnificationXref
id: 57-04-5
db: CAS

Reference/UniProt P31040
type: UnificationXref
id: P31040
db: UniProt

Reference/ChEBI CHEBI 15741
type: UnificationXref
id: CHEBI:15741
db: ChEBI

Cytochrome b
type: ProteinReference
xref: Reference/UniProt P00156
organism: Homo sapiens

Cytochrome b-c1 complex subunit 7
type: ProteinReference
xref: Reference/UniProt P14927
organism: Homo sapiens

Cytochrome c1, heme protein, mitochondrial
type: ProteinReference
xref: Reference/UniProt P08574
organism: Homo sapiens

Cytochrome b-c1 complex subunit Rieske, mitochondrial
type: ProteinReference
xref: Reference/UniProt P47985
organism: Homo sapiens

ATP synthase subunit epsilon, mitochondrial
type: ProteinReference
xref: Reference/UniProt P56381

ATP synthase subunit gamma, mitochondrial
type: ProteinReference
xref: Reference/UniProt P36542

Cytochrome b-c1 complex subunit 1, mitochondrial
type: ProteinReference
xref: Reference/UniProt P31930
organism: Homo sapiens

Cytochrome b-c1 complex subunit 9
type: ProteinReference
xref: Reference/UniProt Q9UDW1
organism: Homo sapiens

Reference/PubChem-compound 1110
type: UnificationXref
id: 1110
db: PubChem-compound

Compound/PW C000081 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycerol 3-phosphate
stoichiometric coefficient: 1.0

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/UniProt P47985
type: UnificationXref
id: P47985
db: UniProt

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005743
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 15978
type: UnificationXref
id: CHEBI:15978
db: ChEBI

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

Succinic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000254
xref: Reference/CAS 110-15-6
xref: Reference/ChEBI CHEBI 15741
xref: Reference/KEGG Compound C00042
xref: Reference/ChemSpider 1078
xref: Reference/PubChem-compound 1110
xref: Reference/BioCyc SUC
chemical formula: C4H6O4
molecular weight: 118.02661
structure: ChemicalStructure/PW C000174

Compound/PW C000081 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycerol 3-phosphate
stoichiometric coefficient: 1.0

Cytochrome b
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome b

Water
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Water

Reference/UniProt P15954
type: UnificationXref
id: P15954
db: UniProt

Compound/PW C040034 Mitochondrial Inner Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 4.0

Cytochrome b-c1 complex subunit 6, mitochondrial
type: ProteinReference
xref: Reference/UniProt P07919
organism: Homo sapiens

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Reference/UniProt P24539
type: UnificationXref
id: P24539
db: UniProt

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/HMDB HMDB0000126
type: UnificationXref
id: HMDB0000126
db: HMDB

D-Glyceraldehyde 3-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glyceraldehyde 3-phosphate
name: SubPathwayOutput

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

Compound/PW C000721/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000128
type: UnificationXref
id: SMP0000128
db: SMPDB

Reference/UniProt P30049
type: UnificationXref
id: P30049
db: UniProt

Reference/ChemSpider 24603698
type: UnificationXref
id: 24603698
db: ChemSpider

Cytochrome b-c1 complex subunit 10
type: ProteinReference
xref: Reference/UniProt O14957
organism: Homo sapiens

Cytochrome c oxidase subunit 5B, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c oxidase subunit 5B, mitochondrial

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000846
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Dihydroxyacetone phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Dihydroxyacetone phosphate

Cytochrome b-c1 complex subunit 7
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome b-c1 complex subunit 7

Cytochrome c oxidase subunit 3
type: ProteinReference
xref: Reference/UniProt P00414
organism: Homo sapiens

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Reference/UniProt P14927
type: UnificationXref
id: P14927
db: UniProt

ADP/ATP translocase 1
type: ProteinReference
xref: Reference/UniProt P12235

Fumaric acid
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Fumaric acid

Protein/174 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/ChemSpider 1078
type: UnificationXref
id: 1078
db: ChemSpider

Cytochrome c oxidase subunit 2
type: ProteinReference
xref: Reference/UniProt P00403
organism: Homo sapiens

Cytochrome c oxidase subunit 5A, mitochondrial
type: ProteinReference
xref: Reference/UniProt P20674
organism: Homo sapiens

Cytochrome b-c1 complex, complex III
type: Complex
component stoichiometry: Protein/924 Mitochondrial Inner Membrane/Stoichiometry/2.0
cellular location: Mitochondrial Inner Membrane
component: Cytochrome b
component: Cytochrome b-c1 complex subunit 7
component: Cytochrome b-c1 complex subunit 1, mitochondrial
component: Cytochrome c1, heme protein, mitochondrial
component: Cytochrome b-c1 complex subunit Rieske, mitochondrial
component: Cytochrome b-c1 complex subunit 8
component: Cytochrome b-c1 complex subunit 6, mitochondrial
component: Cytochrome b-c1 complex subunit 2, mitochondrial
component: Cytochrome b-c1 complex subunit 9
component: Cytochrome b-c1 complex subunit 10

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

ChemicalStructure/PW C000983
type: ChemicalStructure
structure format: SMILES
structure data: O[C@H](COP(O)(O)=O)C(=O)OP(O)(O)=O

Cytochrome b-c1 complex subunit 9
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome b-c1 complex subunit 9

Compound/PW C000414 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt P00403
type: UnificationXref
id: P00403
db: UniProt

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

TransportCatalysis180
type: Catalysis
controller: ADP/ATP translocase 1
controlled: Transport218
control type: ACTIVATION

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Glucose-6-phosphate translocase
type: Protein
entity reference: Glucose-6-phosphate translocase

Dihydroxyacetone phosphate
type: SmallMolecule
cellular location: Mitochondrial Intermembrane Space
entity reference: Dihydroxyacetone phosphate

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Cytochrome c oxidase subunit 5B, mitochondrial
type: ProteinReference
xref: Reference/UniProt P10606
organism: Homo sapiens

Cytochrome b-c1 complex subunit 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt P22695
organism: Homo sapiens

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Cytochrome c oxidase subunit 2
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome c oxidase subunit 2

Coenzyme Q10
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Coenzyme Q10

Compound/PW C001134 Mitochondrial Intermembrane Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroxyacetone phosphate
stoichiometric coefficient: 1.0

TransportCatalysis179
type: Catalysis
controller: Glucose-6-phosphate translocase
controlled: Transport215
control type: ACTIVATION

Reference/UniProt P00414
type: UnificationXref
id: P00414
db: UniProt

ATP synthase subunit b, mitochondrial
type: Protein
entity reference: ATP synthase subunit b, mitochondrial

Cytochrome c oxidase subunit 7B, mitochondrial
type: ProteinReference
xref: Reference/UniProt P24311
organism: Homo sapiens

Compound/PW C001144/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Cytochrome c oxidase subunit 6A2, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q02221
organism: Homo sapiens

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

ChemicalStructure/PW C000835
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(OC)C(O)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(C)=C1O

Glycerol 3-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glycerol 3-phosphate

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

ATP synthase lipid-binding protein, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q06055

Reference/UniProt P25705
type: UnificationXref
id: P25705
db: UniProt

ATP synthase subunit delta, mitochondrial
type: ProteinReference
xref: Reference/UniProt P30049

Glycerol-3-phosphate dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Intermembrane Space
entity reference: Glycerol-3-phosphate dehydrogenase, mitochondrial

Cytochrome c oxidase subunit 7C, mitochondrial
type: ProteinReference
xref: Reference/UniProt P15954
organism: Homo sapiens

Reference/UniProt P99999
type: UnificationXref
id: P99999
db: UniProt

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

ATP synthase subunit a
type: ProteinReference
xref: Reference/UniProt P00846

Cytochrome c oxidase subunit 1
type: ProteinReference
xref: Reference/UniProt P00395
organism: Homo sapiens

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: ProteinReference
xref: Reference/UniProt P21912
organism: Homo sapiens

Compound/PW C001104 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Reference/CAS 110-15-6
type: UnificationXref
id: 110-15-6
db: CAS

Mitochondrial Intermembrane Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005758

Protein/188 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/CAS 17989-41-2
type: UnificationXref
id: 17989-41-2
db: CAS

Reference/ChEBI CHEBI 16108
type: UnificationXref
id: CHEBI:16108
db: ChEBI

Cytochrome b-c1 complex subunit 6, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome b-c1 complex subunit 6, mitochondrial

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
type: ProteinReference
xref: Reference/UniProt P13073
organism: Homo sapiens

Glyceric acid 1,3-biphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glyceric acid 1,3-biphosphate
name: SubPathwayInput

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Reference/UniProt P00846
type: UnificationXref
id: P00846
db: UniProt

Reference/UniProt P20674
type: UnificationXref
id: P20674
db: UniProt

Reference/UniProt O15239
type: UnificationXref
id: O15239
db: UniProt

Cytochrome b-c1 complex subunit 8
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome b-c1 complex subunit 8

Glycerol-3-phosphate dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P43304
organism: Homo sapiens

Cytochrome b-c1 complex subunit 10
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Cytochrome b-c1 complex subunit 10

Reference/ChEBI CHEBI 61682
type: UnificationXref
id: CHEBI:61682
db: ChEBI

Reference/UniProt P09669
type: UnificationXref
id: P09669
db: UniProt

Reference/UniProt P08574
type: UnificationXref
id: P08574
db: UniProt

Reference/PathWhiz PW000005
type: UnificationXref
id: PW000005
db: PathWhiz

Compound/PW C000846 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme Q10
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000869
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C=O

Reference/UniProt P43304
type: UnificationXref
id: P43304
db: UniProt

ATP synthase subunit alpha, mitochondrial
type: Protein
entity reference: ATP synthase subunit alpha, mitochondrial

Reference/BioCyc GAP
type: UnificationXref
id: GAP
db: BioCyc

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

ReactionCoupledTransportCatalysis563
type: Catalysis
controller: Cytochrome b-c1 complex, complex III
controlled: ReactionCoupledTransport516
control type: ACTIVATION

Reference/KEGG Compound C00661
type: UnificationXref
id: C00661
db: KEGG Compound

ReactionCoupledTransportCatalysis560
type: Catalysis
controller: Cytochrome c oxidase complex IV
controlled: 1.9.3.1
control type: ACTIVATION

ReactionCatalysis2005
type: Catalysis
controller: Glyceraldehyde-3-phosphate dehydrogenase
controlled: Reaction2164
control type: ACTIVATION

ReactionCoupledTransportCatalysis41
type: Catalysis
controller: ATP synthase subunit alpha, mitochondrial
controlled: ReactionCoupledTransport40
control type: ACTIVATION

Reference/UniProt Q02221
type: UnificationXref
id: Q02221
db: UniProt

ReactionCoupledTransportCatalysis40
type: Catalysis
controller: ATP synthase lipid-binding protein, mitochondrial
controlled: ReactionCoupledTransport40
control type: ACTIVATION

Reference/SMPDB SMP0000355
type: UnificationXref
id: SMP0000355
db: SMPDB

ReactionCoupledTransportCatalysis47
type: Catalysis
controller: ATP synthase subunit a
controlled: ReactionCoupledTransport40
control type: ACTIVATION

ReactionCoupledTransportCatalysis46
type: Catalysis
controller: ATP synthase subunit gamma, mitochondrial
controlled: ReactionCoupledTransport40
control type: ACTIVATION

Reference/BioCyc UBIQUINONE-10
type: UnificationXref
id: UBIQUINONE-10
db: BioCyc

ReactionCoupledTransportCatalysis48
type: Catalysis
controller: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
controlled: ReactionCoupledTransport41
control type: ACTIVATION

Compound/PW C000846/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme Q10
stoichiometric coefficient: 1.0

ReactionCatalysis2002
type: Catalysis
controller: Glycerol-3-phosphate dehydrogenase, mitochondrial
controlled: 1.1.5.3
control type: ACTIVATION

ReactionCoupledTransportCatalysis43
type: Catalysis
controller: ATP synthase subunit beta, mitochondrial
controlled: ReactionCoupledTransport40
control type: ACTIVATION

ReactionCoupledTransportCatalysis42
type: Catalysis
controller: ATP synthase subunit epsilon, mitochondrial
controlled: ReactionCoupledTransport40
control type: ACTIVATION

ReactionCoupledTransportCatalysis45
type: Catalysis
controller: ATP synthase subunit delta, mitochondrial
controlled: ReactionCoupledTransport40
control type: ACTIVATION

ReactionCatalysis2003
type: Catalysis
controller: Succinate dehydrogenase
controlled: 1.3.5.1
control type: ACTIVATION

ReactionCoupledTransportCatalysis44
type: Catalysis
controller: ATP synthase subunit b, mitochondrial
controlled: ReactionCoupledTransport40
control type: ACTIVATION