Reference/UniProt P06213
type: UnificationXref
id: P06213
db: UniProt

Insulin receptor substrate 2
type: Protein
cellular location: Cytoplasm
entity reference: Insulin receptor substrate 2

Insulin receptor substrate 1
type: Protein
cellular location: Cytosol
entity reference: Insulin receptor substrate 1

Reference/UniProt P28482
type: UnificationXref
id: P28482
db: UniProt

Reaction2221
type: BiochemicalReaction
participant stoichiometry: Protein/5154 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/5797 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/1069 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/5795 Cytosol/Stoichiometry/1.0
right: GRB2-IRS-SHC complex
spontaneous: true
left: SHC-transforming protein 1
left: Growth factor receptor-bound protein 2
left: Insulin receptor substrate 1
name: Growth factor receptor-bound protein 2 + Insulin receptor substrate 1 with Phosphorylation + SHC-transforming protein 1 with phosphorylation → GRB2-IRS-SHC complex
conversion direction: LEFT_TO_RIGHT

Reaction2222
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/1069 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/1070 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/3798 Cytosol/Stoichiometry/1.0
right: GRB2-SOS-IRS-SHC complex
spontaneous: true
left: GRB2-IRS-SHC complex
left: Son of sevenless homolog 1
name: GRB2-IRS-SHC complex + Son of sevenless homolog 1 → GRB2-SOS-IRS-SHC complex
conversion direction: LEFT_TO_RIGHT

Protein/5795 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Insulin receptor substrate 1
stoichiometric coefficient: 1.0

Protein/1084 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: RAF proto-oncogene serine/threonine-protein kinase
stoichiometric coefficient: 1.0

direct_interaction
type: InteractionVocabulary

Reaction2220
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/1064 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/5795 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/5796 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/1063 Cytosol/Stoichiometry/1.0
right: Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
spontaneous: true
left: Phosphatidylinositol 4,5-bisphosphate 3-kinase
left: Insulin receptor substrate 2
left: Insulin receptor substrate 1
name: Insulin receptor substrate 1 with Phosphorylation + Insulin receptor substrate 2 with Phosphorylation + Phosphatidylinositol 4,5-bisphosphate 3-kinase → Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
conversion direction: LEFT_TO_RIGHT

Insulin Signalling
type: Pathway
pathway order: PathwayEnzymeReaction/3081
pathway order: PathwaySubPathway/795
pathway order: PathwayEnzymeReaction/3093
pathway order: PathwaySubPathway/771
pathway order: PathwaySubPathway/761
pathway order: PathwayEnzymeReaction/2119624
pathway order: PathwayEnzymeReaction/3080
pathway order: PathwayEnzymeReaction/3067
pathway order: PathwayEnzymeReaction/3089
pathway order: PathwayEnzymeReaction/3221
pathway order: PathwayEnzymeReaction/3079
pathway order: PathwayTransport/3025
pathway order: PathwayEnzymeReaction/3075
pathway order: PathwayEnzymeReaction/3065
pathway order: PathwayEnzymeReaction/3066
pathway order: PathwayEnzymeReaction/3077
pathway order: PathwayEnzymeReaction/3220
pathway order: PathwayEnzymeReaction/3231
pathway order: PathwayEnzymeReaction/3229
pathway order: PathwayInteraction/1699
pathway order: PathwaySubPathway/109509
pathway order: PathwayEnzymeReaction/3217
pathway order: PathwayInteraction/1698
pathway component: TransportCatalysis186
pathway component: SubPathwayControl761
pathway component: Reaction2221
pathway component: Reaction2222
pathway component: 2.7.12.2
pathway component: Reaction2220
pathway component: 2.7.11.1
pathway component: Reaction2260
pathway component: ReactionCatalysis2075
pathway component: 2.7.10.1
pathway component: Reaction2223
pathway component: Starch and Sucrose Metabolism
pathway component: ReactionCatalysis2082
pathway component: SubPathwayControl771
pathway component: ReactionCatalysis2081
pathway component: SubPathwayControl109509
pathway component: ReactionCatalysis2084
pathway component: ReactionCatalysis2083
pathway component: Reaction179012
pathway component: ReactionCatalysis2126
pathway component: Interaction1699
pathway component: Interaction1698
pathway component: Reaction2218
pathway component: Reaction2219
pathway component: ReactionCatalysis2088
pathway component: ReactionCatalysis2123
pathway component: Transport226
pathway component: ReactionCatalysis2125
pathway component: ReactionCatalysis2124
xref: Reference/SMPDB SMP0000391
xref: Reference/PathWhiz PW000454
organism: Homo sapiens

Protein/1703 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GTPase HRas
stoichiometric coefficient: 1.0

2.7.10.1
type: BiochemicalReaction
participant stoichiometry: Protein/5796 Cytosol/Stoichiometry/1.0
right: Insulin receptor substrate 2
spontaneous: false
EC number: 2.7.10.1
left: Insulin receptor substrate 2
name: Insulin receptor substrate 2 → Insulin receptor substrate 2 with Phosphorylation
conversion direction: LEFT_TO_RIGHT

2.7.10.1
type: BiochemicalReaction
participant stoichiometry: Protein/5797 Cytosol/Stoichiometry/1.0
right: SHC-transforming protein 1
spontaneous: false
EC number: 2.7.10.1
left: SHC-transforming protein 1
name: SHC-transforming protein 1 → SHC-transforming protein 1 with phosphorylation
conversion direction: LEFT_TO_RIGHT

Reaction2223
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/1703 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
right: Guanosine diphosphate
right: GTPase HRas
spontaneous: false
left: GTPase HRas
left: Guanosine triphosphate
name: GTPase HRas with GDP + Guanosine triphosphate → GTPase HRas with GTP + Guanosine diphosphate
conversion direction: LEFT_TO_RIGHT

2.7.10.1
type: BiochemicalReaction
participant stoichiometry: Protein/5795 Cytosol/Stoichiometry/1.0
right: Insulin receptor substrate 1
spontaneous: false
EC number: 2.7.10.1
left: Insulin receptor substrate 1
name: Insulin receptor substrate 1 → Insulin receptor substrate 1 with Phosphorylation
conversion direction: LEFT_TO_RIGHT

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: Reference/UniProt O15530
organism: Homo sapiens

Carbohydrate
type: SmallMoleculeReference

Reference/UniProt P04049
type: UnificationXref
id: P04049
db: UniProt

Reference/UniProt P35568
type: UnificationXref
id: P35568
db: UniProt

Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
type: Complex
component stoichiometry: Protein/5794 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/5796 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/5795 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1297 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
component: Phosphoinositide 3-kinase regulatory subunit 6
component: Insulin receptor substrate 2
component: Insulin receptor substrate 1

RAC-alpha serine/threonine-protein kinase
type: Protein
cellular location: Mitochondrial Matrix
entity reference: RAC-alpha serine/threonine-protein kinase

Protein/1703 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: GTPase HRas
stoichiometric coefficient: 1.0

PIP3(16:0/16:0)
type: SmallMolecule
cellular location: Cytoplasm
entity reference: PIP3(16:0/16:0)

ProteinComplex/1070 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GRB2-SOS-IRS-SHC complex
stoichiometric coefficient: 1.0

Insulin receptor substrate 1
type: Protein
cellular location: Cytoplasm
entity reference: Insulin receptor substrate 1

Reference/SMPDB SMP0120895
type: UnificationXref
id: SMP0120895
db: SMPDB

Reference/PathWhiz PW122156
type: UnificationXref
id: PW122156
db: PathWhiz

Reaction2218
type: BiochemicalReaction
participant stoichiometry: Compound/PW C006073 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C006188 Cytoplasm/Stoichiometry/1.0
right: PIP3(16:0/16:0)
spontaneous: false
left: PIP2(16:0/16:0)
name: PIP2(16:0/16:0) → PIP3(16:0/16:0)
conversion direction: LEFT_TO_RIGHT

Reaction2219
type: BiochemicalReaction
participant stoichiometry: Protein/1703 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/1062 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/1063 Cytosol/Stoichiometry/1.0
right: Activated Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
spontaneous: true
left: GTPase HRas
left: Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
name: GTPase HRas with GTP + Phosphatidylinositol 4,5-bisphosphate 3-kinase complex → Activated Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
conversion direction: LEFT_TO_RIGHT

Protein/3798 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Son of sevenless homolog 1
stoichiometric coefficient: 1.0

Insulin receptor activation by insulin
type: Pathway
name: ActivatingSubPathway

RAC-alpha serine/threonine-protein kinase
type: Protein
cellular location: Cytosol
entity reference: RAC-alpha serine/threonine-protein kinase

Reference/UniProt P29353
type: UnificationXref
id: P29353
db: UniProt

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Protein/5796 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Insulin receptor substrate 2
stoichiometric coefficient: 1.0

Insulin
type: Protein
cellular location: Extracellular Space
entity reference: Insulin

GLUT4 activation by AKT
type: Pathway
name: ActivatingSubPathway

Reference/BRENDA TISSUE ONTOLOGY BTO 0000648
type: UnificationXref
id: BTO:0000648
db: BRENDA TISSUE ONTOLOGY

Carbohydrate
type: SmallMolecule
entity reference: Carbohydrate
name: SubPathwayActivator

Reference/ChemSpider 24767909
type: UnificationXref
id: 24767909
db: ChemSpider

Insulin receptor
type: Protein
cellular location: Cell Membrane
entity reference: Insulin receptor
name: SubPathwayActivation

Starch and Sucrose Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway795
pathway component: SubPathwayInteraction795
xref: Reference/SMPDB SMP0000058
xref: Reference/PathWhiz PW000150
name: SubPathway

Reference/UniProt P01112
type: UnificationXref
id: P01112
db: UniProt

GTPase HRas
type: Protein
cellular location: Cytosol
entity reference: GTPase HRas

Reference/UniProt O15530
type: UnificationXref
id: O15530
db: UniProt

Reference/PubChem-compound 6830
type: UnificationXref
id: 6830
db: PubChem-compound

Reference/PathWhiz PW000150
type: UnificationXref
id: PW000150
db: PathWhiz

Guanosine diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001201
xref: Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
xref: Reference/CAS 146-91-8
xref: Reference/PubChem-compound 8977
xref: Reference/ChEBI CHEBI 17552
xref: Reference/ChemSpider 8630
xref: Reference/KEGG Compound C00035
chemical formula: C10H15N5O11P2
molecular weight: 443.02432
structure: ChemicalStructure/PW C000936

Compound/PW C006073 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP2(16:0/16:0)
stoichiometric coefficient: 1.0

Interaction1699
type: MolecularInteraction
interaction type: direct_interaction
name: Mitogen-activated protein kinase 8 inhibits Insulin receptor
participant: Insulin receptor
participant: Mitogen-activated protein kinase 8

2.7.11.1
type: BiochemicalReaction
participant stoichiometry: Protein/1292 Cytosol/Stoichiometry/1.0
right: RAC-alpha serine/threonine-protein kinase
spontaneous: false
EC number: 2.7.11.1
left: RAC-alpha serine/threonine-protein kinase
name: RAC-alpha serine/threonine-protein kinase → RAC-alpha serine/threonine-protein kinase with phosphorylation
conversion direction: LEFT_TO_RIGHT

Protein/3798 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Son of sevenless homolog 1
stoichiometric coefficient: 1.0

Interaction1698
type: MolecularInteraction
interaction type: direct_interaction
name: RAC-alpha serine/threonine-protein kinase activates Forkhead box protein O1
participant: RAC-alpha serine/threonine-protein kinase
participant: Forkhead box protein O1

Protein/5797 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: SHC-transforming protein 1
stoichiometric coefficient: 1.0

Reference/UniProt P36507
type: UnificationXref
id: P36507
db: UniProt

Guanosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15996
xref: Reference/ChemSpider 6569
xref: Reference/KEGG Compound C00044
xref: Reference/PubChem-compound 6830
xref: Reference/HMDB HMDB0001273
xref: Reference/CAS 86-01-1
xref: Reference/BioCyc GTP
chemical formula: C10H16N5O14P3
molecular weight: 522.99066
structure: ChemicalStructure/PW C000986

SHC-transforming protein 1
type: Protein
cellular location: Cytosol
entity reference: SHC-transforming protein 1

Guanosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine triphosphate

Mitogen-activated protein kinase 1
type: ProteinReference
xref: Reference/UniProt P28482
organism: Homo sapiens

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Growth factor receptor-bound protein 2
type: ProteinReference
xref: Reference/UniProt P62993
organism: Homo sapiens

SHC-transforming protein 1
type: Protein
cellular location: Cell Membrane
entity reference: SHC-transforming protein 1

Reference/UniProt P48736
type: UnificationXref
id: P48736
db: UniProt

Protein/1292 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: RAC-alpha serine/threonine-protein kinase
stoichiometric coefficient: 1.0

2.7.12.2
type: BiochemicalReaction
participant stoichiometry: Protein/1117 Cytosol/Stoichiometry/1.0
right: Mitogen-activated protein kinase 1
spontaneous: false
EC number: 2.7.12.2
left: Mitogen-activated protein kinase 1
name: Inactive Mitogen-activated protein kinase 1 → Active Mitogen-activated protein kinase 1
conversion direction: LEFT_TO_RIGHT

Protein/1297 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
stoichiometric coefficient: 1.0

2.7.12.2
type: BiochemicalReaction
participant stoichiometry: Protein/1117 Cytosol/Stoichiometry/1.0
right: Mitogen-activated protein kinase 1
spontaneous: false
EC number: 2.7.12.2
left: Mitogen-activated protein kinase 1
name: Inactive Mitogen-activated protein kinase 1 → Active Mitogen-activated protein kinase 1
conversion direction: LEFT_TO_RIGHT

2.7.11.1
type: BiochemicalReaction
participant stoichiometry: Protein/5788 Cell Membrane/Stoichiometry/1.0
right: Dual specificity mitogen-activated protein kinase kinase 1
spontaneous: false
EC number: 2.7.11.1
left: Dual specificity mitogen-activated protein kinase kinase 1
name: Inactive Dual specificity mitogen-activated protein kinase kinase 1 → Active Dual specificity mitogen-activated protein kinase kinase 1
conversion direction: LEFT_TO_RIGHT

2.7.11.1
type: BiochemicalReaction
participant stoichiometry: Protein/4632 Cell Membrane/Stoichiometry/1.0
right: Dual specificity mitogen-activated protein kinase kinase 2
spontaneous: false
EC number: 2.7.11.1
left: Dual specificity mitogen-activated protein kinase kinase 2
name: Inactive Dual specificity mitogen-activated protein kinase kinase 2 → Active Dual specificity mitogen-activated protein kinase kinase 2
conversion direction: LEFT_TO_RIGHT

Reaction2260
type: BiochemicalReaction
participant stoichiometry: Protein/1084 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/1085 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/1703 Cell Membrane/Stoichiometry/1.0
right: RAF proto-oncogene serine/threonine-protein kinase recruited by GTPase HRas
spontaneous: true
left: GTPase HRas
left: RAF proto-oncogene serine/threonine-protein kinase
name: GTPase HRas with GTP + RAF proto-oncogene serine/threonine-protein kinase → RAF proto-oncogene serine/threonine-protein kinase recruited by GTPase HRas
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

Protein/5795 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Insulin receptor substrate 1
stoichiometric coefficient: 1.0

Compound/PW C000077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/BioCyc Phosphatidylinositols
type: UnificationXref
id: Phosphatidylinositols
db: BioCyc

Insulin secretion
type: Pathway
xref: Reference/SMPDB SMP0120895
xref: Reference/PathWhiz PW122156
name: ActivatingSubPathway

Reference/PubChem-compound 53480223
type: UnificationXref
id: 53480223
db: PubChem-compound

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: Reference/UniProt P36507
organism: Homo sapiens

Reference/HMDB HMDB0010147
type: UnificationXref
id: HMDB0010147
db: HMDB

ChemicalStructure/PW C000936
type: ChemicalStructure
structure format: SMILES

Reaction179012
type: BiochemicalReaction
participant stoichiometry: Protein/8837 Mitochondrial Matrix/Stoichiometry/1.0
right: Forkhead box protein O1
spontaneous: false
left: Forkhead box protein O1
name: Forkhead box protein O1 → Forkhead box protein O1 with phosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 35366
type: UnificationXref
id: CHEBI:35366
db: ChEBI

Reference/UniProt Q07889
type: UnificationXref
id: Q07889
db: UniProt

RAC-alpha serine/threonine-protein kinase
type: Protein
cellular location: Cytoplasm
entity reference: RAC-alpha serine/threonine-protein kinase
name: SubPathwayActivator

Insulin
type: Protein
entity reference: Insulin

Phosphoinositide 3-kinase regulatory subunit 6
type: Protein
cellular location: Cytosol
entity reference: Phosphoinositide 3-kinase regulatory subunit 6

Reference/BioCyc GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
type: UnificationXref
id: GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE
db: BioCyc

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Solute carrier family 2, facilitated glucose transporter member 4
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 4

Intestine
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000648

Reference/SMPDB SMP0000058
type: UnificationXref
id: SMP0000058
db: SMPDB

Insulin receptor
type: Protein
cellular location: Cytosol
entity reference: Insulin receptor

PIP3(16:0/16:0)
type: SmallMoleculeReference
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/KEGG Compound C00626
xref: Reference/HMDB HMDB0010147
xref: Reference/ChemSpider 24768024
chemical formula: C41H82O22P4
molecular weight: 1050.4248
structure: ChemicalStructure/PW C006188

Protein/8837 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Forkhead box protein O1
stoichiometric coefficient: 1.0

Insulin
type: Complex
component stoichiometry: Protein/5775 Extracellular Space/Stoichiometry/2.0
cellular location: Extracellular Space
component: Insulin
name: SubPathwayActivator

Reference/HMDB HMDB0010032
type: UnificationXref
id: HMDB0010032
db: HMDB

3-phosphoinositide-dependent protein kinase 1
type: Protein
cellular location: Cytosol
entity reference: 3-phosphoinositide-dependent protein kinase 1

Insulin receptor substrate 1
type: Protein
cellular location: Cell Membrane
entity reference: Insulin receptor substrate 1

Son of sevenless homolog 1
type: ProteinReference
xref: Reference/UniProt Q07889
organism: Homo sapiens

SubPathwayControl761
type: Interaction
name: SubPathway761Control
name: ActivatingSubPathwayControl
participant: Insulin receptor activation by insulin
participant: Insulin receptor
participant: Insulin

Dual specificity mitogen-activated protein kinase kinase 2
type: Protein
cellular location: Cytosol
entity reference: Dual specificity mitogen-activated protein kinase kinase 2

ProteinComplex/1085 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: RAF proto-oncogene serine/threonine-protein kinase recruited by GTPase HRas
stoichiometric coefficient: 1.0

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/HMDB HMDB0001201
type: UnificationXref
id: HMDB0001201
db: HMDB

Reference/UniProt P01308
type: UnificationXref
id: P01308
db: UniProt

Phosphoinositide 3-kinase regulatory subunit 6
type: Protein
cellular location: Cytoplasm
entity reference: Phosphoinositide 3-kinase regulatory subunit 6

Reference/UniProt Q02750
type: UnificationXref
id: Q02750
db: UniProt

ReactionCatalysis2075
type: Catalysis
controller: Activated Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
controlled: Reaction2218
control type: ACTIVATION

Solute carrier family 2, facilitated glucose transporter member 4
type: Protein
cellular location: Cell Membrane
entity reference: Solute carrier family 2, facilitated glucose transporter member 4
name: SubPathwayActivation

Protein/1703 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: GTPase HRas
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 2
type: Protein
cellular location: Cell Membrane
entity reference: Dual specificity mitogen-activated protein kinase kinase 2

GTPase HRas
type: ProteinReference
xref: Reference/UniProt P01112
organism: Homo sapiens

ReactionCatalysis2082
type: Catalysis
controller: Insulin receptor
controlled: 2.7.10.1
control type: ACTIVATION

ReactionCatalysis2081
type: Catalysis
controller: GRB2-SOS-IRS-SHC complex
controlled: Reaction2223
control type: ACTIVATION

Reference/ChEBI CHEBI 15996
type: UnificationXref
id: CHEBI:15996
db: ChEBI

ReactionCatalysis2084
type: Catalysis
controller: Insulin receptor
controlled: 2.7.10.1
control type: ACTIVATION

ReactionCatalysis2083
type: Catalysis
controller: Insulin receptor
controlled: 2.7.10.1
control type: ACTIVATION

Reference/UniProt Q5UE93
type: UnificationXref
id: Q5UE93
db: UniProt

Reference/UniProt P31749
type: UnificationXref
id: P31749
db: UniProt

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

Protein/5794 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoinositide 3-kinase regulatory subunit 6
stoichiometric coefficient: 1.0

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: Protein
cellular location: Cytoplasm
entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/UniProt Q12778
type: UnificationXref
id: Q12778
db: UniProt

ReactionCatalysis2088
type: Catalysis
controller: 3-phosphoinositide-dependent protein kinase 1
controlled: 2.7.11.1
control type: ACTIVATION

BiologicalState60
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Intestine
tissue: Intestine

Protein/1297 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
stoichiometric coefficient: 1.0

Guanosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Guanosine diphosphate

SubPathwayInteraction795
type: Interaction
name: SubPathwayReaction
name: SubPathway795Reaction
participant: D-Glucose

PIP2(16:0/16:0)
type: SmallMolecule
cellular location: Cytoplasm
entity reference: PIP2(16:0/16:0)

Mitogen-activated protein kinase 1
type: Protein
cellular location: Cytosol
entity reference: Mitogen-activated protein kinase 1

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Protein/5796 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Insulin receptor substrate 2
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00035
type: UnificationXref
id: C00035
db: KEGG Compound

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

D-Glucose
type: SmallMolecule
cellular location: Extracellular Space
entity reference: D-Glucose

Growth factor receptor-bound protein 2
type: Protein
cellular location: Cell Membrane
entity reference: Growth factor receptor-bound protein 2

SubPathwayControl771
type: Interaction
name: SubPathway771Control
name: ActivatingSubPathwayControl
participant: GLUT4 activation by AKT
participant: Solute carrier family 2, facilitated glucose transporter member 4
participant: RAC-alpha serine/threonine-protein kinase

Son of sevenless homolog 1
type: Protein
cellular location: Cell Membrane
entity reference: Son of sevenless homolog 1

Reference/PathWhiz PW000454
type: UnificationXref
id: PW000454
db: PathWhiz

Insulin receptor
type: Protein
entity reference: Insulin receptor

Reference/KEGG Compound C00044
type: UnificationXref
id: C00044
db: KEGG Compound

Reference/ChemSpider 24768024
type: UnificationXref
id: 24768024
db: ChemSpider

Protein/1117 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Mitogen-activated protein kinase 1
stoichiometric coefficient: 1.0

GTPase HRas
type: Protein
cellular location: Cell Membrane
entity reference: GTPase HRas

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt P31749
organism: Homo sapiens

Reference/UniProt Q9Y4H2
type: UnificationXref
id: Q9Y4H2
db: UniProt

Growth factor receptor-bound protein 2
type: Protein
cellular location: Cytosol
entity reference: Growth factor receptor-bound protein 2

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Son of sevenless homolog 1
type: Protein
cellular location: Cytosol
entity reference: Son of sevenless homolog 1

Compound/PW C000986 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine triphosphate
stoichiometric coefficient: 1.0

TransportCatalysis186
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 4
controlled: Transport226
control type: ACTIVATION

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: Reference/UniProt P48736
organism: Homo sapiens

Insulin receptor substrate 2
type: Protein
cellular location: Cytosol
entity reference: Insulin receptor substrate 2

Mitogen-activated protein kinase 8
type: Protein
entity reference: Mitogen-activated protein kinase 8

Insulin
type: ProteinReference
xref: Reference/UniProt P01308
organism: Homo sapiens

Solute carrier family 2, facilitated glucose transporter member 4
type: ProteinReference
xref: Reference/UniProt P14672

Protein/5154 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Growth factor receptor-bound protein 2
stoichiometric coefficient: 1.0

Activated Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
type: Complex
component stoichiometry: Protein/1703 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/1297 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/5796 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/5795 Cytoplasm/Stoichiometry/1.0
component stoichiometry: Protein/5794 Cytoplasm/Stoichiometry/1.0
cellular location: Cytoplasm
component: Phosphoinositide 3-kinase regulatory subunit 6
component: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
component: Insulin receptor substrate 1
component: GTPase HRas
component: Insulin receptor substrate 2

GRB2-SOS-IRS-SHC complex
type: Complex
component stoichiometry: Protein/5154 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/5797 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/3798 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/5795 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: SHC-transforming protein 1
component: Growth factor receptor-bound protein 2
component: Son of sevenless homolog 1
component: Insulin receptor substrate 1

PIP2(16:0/16:0)
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0010032
xref: Reference/BioCyc Phosphatidylinositols
xref: Reference/PubChem-compound 53480223
xref: Reference/KEGG Compound C00626
xref: Reference/ChemSpider 24767909
chemical formula: C41H81O19P3
molecular weight: 970.4585
structure: ChemicalStructure/PW C006073

Reference/KEGG Compound C00626
type: UnificationXref
id: C00626
db: KEGG Compound

GRB2-IRS-SHC complex
type: Complex
component stoichiometry: Protein/5154 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/5797 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/5795 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: SHC-transforming protein 1
component: Growth factor receptor-bound protein 2
component: Insulin receptor substrate 1

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: Reference/UniProt Q02750
organism: Homo sapiens

Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/PubChem-compound 8977
type: UnificationXref
id: 8977
db: PubChem-compound

Reference/SMPDB SMP0000391
type: UnificationXref
id: SMP0000391
db: SMPDB

Protein/5788 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 1
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 1
type: Protein
cellular location: Cytosol
entity reference: Dual specificity mitogen-activated protein kinase kinase 1

Activated Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
type: Complex
component stoichiometry: Protein/5794 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1703 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/5795 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/5796 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1297 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
component: Phosphoinositide 3-kinase regulatory subunit 6
component: GTPase HRas
component: Insulin receptor substrate 2
component: Insulin receptor substrate 1

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: Protein
cellular location: Cytosol
entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

RAF proto-oncogene serine/threonine-protein kinase
type: Protein
cellular location: Cell Membrane
entity reference: RAF proto-oncogene serine/threonine-protein kinase

Protein/5795 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Insulin receptor substrate 1
stoichiometric coefficient: 1.0

Insulin
type: Complex
component stoichiometry: Protein/5775/Stoichiometry/2.0
component: Insulin
name: SubPathwayActivation

Insulin receptor substrate 2
type: ProteinReference
xref: Reference/UniProt Q9Y4H2
organism: Homo sapiens

Fatty Acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 35366

SHC-transforming protein 1
type: ProteinReference
xref: Reference/UniProt P29353
organism: Homo sapiens

Reference/UniProt P62993
type: UnificationXref
id: P62993
db: UniProt

Phosphoinositide 3-kinase regulatory subunit 6
type: ProteinReference
xref: Reference/UniProt Q5UE93
organism: Homo sapiens

Insulin receptor substrate 1
type: ProteinReference
xref: Reference/UniProt P35568
organism: Homo sapiens

Reference/ChemSpider 8630
type: UnificationXref
id: 8630
db: ChemSpider

Reference/UniProt P45983
type: UnificationXref
id: P45983
db: UniProt

Reference/UniProt P14672
type: UnificationXref
id: P14672
db: UniProt

ChemicalStructure/PW C006073
type: ChemicalStructure
structure format: SMILES

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

RAF proto-oncogene serine/threonine-protein kinase recruited by GTPase HRas
type: Complex
component stoichiometry: Protein/1084 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/1703 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: GTPase HRas
component: RAF proto-oncogene serine/threonine-protein kinase

GRB2-SOS-IRS-SHC complex
type: Complex
component stoichiometry: Protein/5795 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/3798 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/5797 Cell Membrane/Stoichiometry/1.0
component stoichiometry: Protein/5154 Cell Membrane/Stoichiometry/1.0
cellular location: Cell Membrane
component: Growth factor receptor-bound protein 2
component: Insulin receptor substrate 1
component: Son of sevenless homolog 1
component: SHC-transforming protein 1

Reference/ChemSpider 6569
type: UnificationXref
id: 6569
db: ChemSpider

Reference/ChEBI CHEBI 17552
type: UnificationXref
id: CHEBI:17552
db: ChEBI

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
xref: Reference/UniProt P04049
organism: Homo sapiens

Reference/BioCyc GTP
type: UnificationXref
id: GTP
db: BioCyc

ProteinComplex/1069 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: GRB2-IRS-SHC complex
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Protein/5794 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoinositide 3-kinase regulatory subunit 6
stoichiometric coefficient: 1.0

Forkhead box protein O1
type: ProteinReference
xref: Reference/UniProt Q12778
organism: Homo sapiens

ProteinComplex/1062 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Activated Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001273
type: UnificationXref
id: HMDB0001273
db: HMDB

Protein
type: DnaReference
organism: BiologicalState60

Protein/5154 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Growth factor receptor-bound protein 2
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

Protein/5775 Extracellular Space/Stoichiometry/2.0
type: Stoichiometry
physical entity: Insulin
stoichiometric coefficient: 2.0

ChemicalStructure/PW C000986
type: ChemicalStructure
structure format: SMILES

Insulin receptor
type: ProteinReference
xref: Reference/UniProt P06213
organism: Homo sapiens

Forkhead box protein O1
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Forkhead box protein O1

ProteinComplex/1063 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate 3-kinase complex
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES

Dual specificity mitogen-activated protein kinase kinase 1
type: Protein
cellular location: Cell Membrane
entity reference: Dual specificity mitogen-activated protein kinase kinase 1

ProteinComplex/1064 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylinositol 4,5-bisphosphate 3-kinase
stoichiometric coefficient: 1.0

Reference/CAS 86-01-1
type: UnificationXref
id: 86-01-1
db: CAS

Protein/5797 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: SHC-transforming protein 1
stoichiometric coefficient: 1.0

Protein/5775/Stoichiometry/2.0
type: Stoichiometry
physical entity: Insulin
stoichiometric coefficient: 2.0

SubPathwayControl109509
type: Interaction
name: ActivatingSubPathwayControl
name: SubPathway109509Control
participant: Insulin secretion
participant: Protein
participant: Insulin
participant: Fatty Acid
participant: Carbohydrate

Mitogen-activated protein kinase 8
type: ProteinReference
xref: Reference/UniProt P45983
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase
type: Complex
component stoichiometry: Protein/5794 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/1297 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
component: Phosphoinositide 3-kinase regulatory subunit 6

Fatty Acid
type: SmallMolecule
entity reference: Fatty Acid
name: SubPathwayActivator

GTPase HRas
type: Protein
cellular location: Cytoplasm
entity reference: GTPase HRas

D-Glucose
type: SmallMolecule
cellular location: Cytoplasm
entity reference: D-Glucose
name: SubPathwayInput

ReactionCatalysis2126
type: Catalysis
controller: Dual specificity mitogen-activated protein kinase kinase 1
controlled: 2.7.12.2
control type: ACTIVATION

Compound/PW C006188 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: PIP3(16:0/16:0)
stoichiometric coefficient: 1.0

Protein/4632 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dual specificity mitogen-activated protein kinase kinase 2
stoichiometric coefficient: 1.0

Protein
type: Dna
entity reference: Protein
name: SubPathwayActivator

Compound/PW C000936 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Guanosine diphosphate
stoichiometric coefficient: 1.0

Reference/CAS 146-91-8
type: UnificationXref
id: 146-91-8
db: CAS

ChemicalStructure/PW C006188
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis2123
type: Catalysis
controller: RAF proto-oncogene serine/threonine-protein kinase recruited by GTPase HRas
controlled: 2.7.11.1
control type: ACTIVATION

Transport226
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Extracellular Space/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis2125
type: Catalysis
controller: Dual specificity mitogen-activated protein kinase kinase 2
controlled: 2.7.12.2
control type: ACTIVATION

ReactionCatalysis2124
type: Catalysis
controller: RAF proto-oncogene serine/threonine-protein kinase recruited by GTPase HRas
controlled: 2.7.11.1
control type: ACTIVATION