Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

ChemicalStructure/PW C000206
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Solute carrier family 2, facilitated glucose transporter member 1
type: ProteinReference
xref: Reference/UniProt P11166

Reference/CAS 2956-16-3
type: UnificationXref
id: 2956-16-3
db: CAS

Reference/BioCyc UDP-GLACTOSE
type: UnificationXref
id: UDP-GLACTOSE
db: BioCyc

Glucose-6-phosphatase
type: Protein
cellular location: Cytosol
entity reference: Glucose-6-phosphatase

Reaction196
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000194 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Uridine 5'-diphosphate
spontaneous: false
left: Adenosine triphosphate
left: Uridine 5'-monophosphate
name: Adenosine triphosphate + Uridine 5'-monophosphate → Adenosine diphosphate + Uridine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 63-42-3
type: UnificationXref
id: 63-42-3
db: CAS

Reference/BioCyc LACTOSE
type: UnificationXref
id: LACTOSE
db: BioCyc

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/UniProt P35575
type: UnificationXref
id: P35575
db: UniProt

Reference/PubChem-compound 6133
type: UnificationXref
id: 6133
db: PubChem-compound

Reference/KEGG Compound C00446
type: UnificationXref
id: C00446
db: KEGG Compound

Compound/PW C000077 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Uridine diphosphategalactose
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine diphosphategalactose

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/BioCyc GALACTOSE-1P
type: UnificationXref
id: GALACTOSE-1P
db: BioCyc

Reference/HMDB HMDB0000302
type: UnificationXref
id: HMDB0000302
db: HMDB

Galactose 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Galactose 1-phosphate

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reaction402
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000192 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Uridine triphosphate
spontaneous: false
left: Adenosine triphosphate
left: Uridine 5'-diphosphate
name: Adenosine triphosphate + Uridine 5'-diphosphate → Adenosine diphosphate + Uridine triphosphate
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/UniProt P15291
type: UnificationXref
id: P15291
db: UniProt

ReactionCatalysis379
type: Catalysis
controller: Galactose-1-phosphate uridylyltransferase
controlled: 2.7.7.12
control type: ACTIVATION

UMP-CMP kinase
type: ProteinReference
xref: Reference/UniProt P30085
organism: Homo sapiens

Reference/PathWhiz PW000049
type: UnificationXref
id: PW000049
db: PathWhiz

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Uridine 5'-monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine 5'-monophosphate

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/CAS 2280-44-6
type: UnificationXref
id: 2280-44-6
db: CAS

Phosphoric acid
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Phosphoric acid

Compound/PW C000206 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphategalactose
stoichiometric coefficient: 1.0

UDP-galactose translocator
type: ProteinReference
xref: Reference/UniProt P78381

Reference/KEGG Compound C00105
type: UnificationXref
id: C00105
db: KEGG Compound

Reference/PubChem-compound 53477679
type: UnificationXref
id: 53477679
db: PubChem-compound

Reference/PubChem-compound 6030
type: UnificationXref
id: 6030
db: PubChem-compound

Reference/PubChem-compound 6031
type: UnificationXref
id: 6031
db: PubChem-compound

Reference/ChEBI CHEBI 15713
type: UnificationXref
id: CHEBI:15713
db: ChEBI

Reference/CAS 133-89-1
type: UnificationXref
id: 133-89-1
db: CAS

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/KEGG Compound C00103
type: UnificationXref
id: C00103
db: KEGG Compound

Reference/UniProt P22392
type: UnificationXref
id: P22392
db: UniProt

UTP--glucose-1-phosphate uridylyltransferase
type: Complex
component stoichiometry: Protein/1008 Cytosol/Stoichiometry/8.0
cellular location: Cytosol
component: UTP--glucose-1-phosphate uridylyltransferase

Reference/PubChem-compound 439165
type: UnificationXref
id: 439165
db: PubChem-compound

ChemicalStructure/PW C000201
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P00709
type: UnificationXref
id: P00709
db: UniProt

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine 5'-diphosphate

Compound/PW C001420 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C000192 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine triphosphate
stoichiometric coefficient: 1.0

Galactose 1-phosphate
type: SmallMoleculeReference
xref: Reference/ChemSpider 110443
xref: Reference/KEGG Compound C00446
xref: Reference/ChEBI CHEBI 17973
xref: Reference/PubChem-compound 123912
xref: Reference/CAS 2255-14-3
xref: Reference/HMDB HMDB0000645
xref: Reference/BioCyc GALACTOSE-1P
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C000504

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Glucose 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Glucose 1-phosphate

Reference/UniProt P78381
type: UnificationXref
id: P78381
db: UniProt

Reference/CAS 59-56-3
type: UnificationXref
id: 59-56-3
db: CAS

Nucleoside diphosphate kinase B
type: ProteinReference
xref: Reference/UniProt P22392
organism: Homo sapiens

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/ChemSpider 388311
type: UnificationXref
id: 388311
db: ChemSpider

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Uridine diphosphate glucose
type: SmallMoleculeReference
xref: Reference/BioCyc UDP-GLUCOSE
xref: Reference/KEGG Compound C00029
xref: Reference/PubChem-compound 53477679
xref: Reference/CAS 133-89-1
xref: Reference/HMDB HMDB0000286
chemical formula: C15H24N2O17P2
molecular weight: 566.055
structure: ChemicalStructure/PW C000193

Reference/BioCyc UDP-GLUCOSE
type: UnificationXref
id: UDP-GLUCOSE
db: BioCyc

Uridine triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6133
xref: Reference/CAS 63-39-8
xref: Reference/ChemSpider 5903
xref: Reference/ChEBI CHEBI 15713
xref: Reference/KEGG Compound C00075
xref: Reference/HMDB HMDB0000285
xref: Reference/BioCyc UTP
chemical formula: C9H15N2O15P3
molecular weight: 483.96854
structure: ChemicalStructure/PW C000192

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Uridine 5'-monophosphate
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Uridine 5'-monophosphate

Reference/ChEBI CHEBI 36219
type: UnificationXref
id: CHEBI:36219
db: ChEBI

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

2.7.7.12
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000193 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000206 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001207 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000504 Cytosol/Stoichiometry/1.0
right: Galactose 1-phosphate
right: Uridine diphosphate glucose
spontaneous: false
EC number: 2.7.7.12
left: Glucose 1-phosphate
left: Uridine diphosphategalactose
name: Glucose 1-phosphate + Uridine diphosphategalactose ↔ Galactose 1-phosphate + Uridine diphosphate glucose
conversion direction: REVERSIBLE

Lactose synthase
type: Complex
component stoichiometry: Protein/364 Golgi Apparatus/Stoichiometry/1.0
component stoichiometry: Protein/369 Golgi Apparatus/Stoichiometry/2.0
cellular location: Golgi Apparatus
component: Alpha-lactalbumin
component: Beta-1,4-galactosyltransferase 1

D-Glucose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000122
xref: Reference/PubChem-compound 5793
xref: Reference/CAS 2280-44-6
xref: Reference/ChemSpider 5589
xref: Reference/ChEBI CHEBI 4167
xref: Reference/BioCyc GLC
xref: Reference/KEGG Compound C00031
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000077

Reference/UniProt P30085
type: UnificationXref
id: P30085
db: UniProt

Uridine diphosphategalactose
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Uridine diphosphategalactose

Uridine 5'-monophosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000288
xref: Reference/CAS 58-97-9
xref: Reference/KEGG Compound C00105
xref: Reference/PubChem-compound 6030
xref: Reference/BioCyc UMP
xref: Reference/ChEBI CHEBI 16695
xref: Reference/ChemSpider 5808
chemical formula: C9H13N2O9P
molecular weight: 324.03586
structure: ChemicalStructure/PW C000194

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

UTP--glucose-1-phosphate uridylyltransferase
type: ProteinReference
xref: Reference/UniProt Q16851
organism: Homo sapiens

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Compound/PW C000194 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-monophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 67119
type: UnificationXref
id: CHEBI:67119
db: ChEBI

Compound/PW C000077 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Glucose
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/BioCyc GLC
type: UnificationXref
id: GLC
db: BioCyc

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/KEGG Compound C00243
type: UnificationXref
id: C00243
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/UniProt Q8WVQ1
type: UnificationXref
id: Q8WVQ1
db: UniProt

Reference/BioCyc GLC-1-P
type: UnificationXref
id: GLC-1-P
db: BioCyc

Compound/PW C000201 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis531
type: Catalysis
controller: Lactose synthase
controlled: Reaction940
control type: ACTIVATION

Reference/PubChem-compound 84571
type: UnificationXref
id: 84571
db: PubChem-compound

Beta-1,4-galactosyltransferase 1
type: ProteinReference
xref: Reference/UniProt P15291
organism: Homo sapiens

Glucose-6-phosphatase
type: ProteinReference
xref: Reference/UniProt P35575
organism: Homo sapiens

Reference/KEGG Compound C00015
type: UnificationXref
id: C00015
db: KEGG Compound

Compound/PW C000194 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-monophosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Alpha-lactalbumin
type: Protein
cellular location: Golgi Apparatus
entity reference: Alpha-lactalbumin

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Alpha-lactalbumin
type: ProteinReference
xref: Reference/UniProt P00709
organism: Homo sapiens

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Compound/PW C000119 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: α-Lactose
stoichiometric coefficient: 1.0

ReactionCatalysis523
type: Catalysis
controller: UMP-CMP kinase
controlled: Reaction196
control type: ACTIVATION

Reference/KEGG Compound C00029
type: UnificationXref
id: C00029
db: KEGG Compound

Galactose-1-phosphate uridylyltransferase
type: Complex
component stoichiometry: Protein/1026 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Galactose-1-phosphate uridylyltransferase

Galactose-1-phosphate uridylyltransferase
type: ProteinReference
xref: Reference/UniProt P07902
organism: Homo sapiens

ChemicalStructure/PW C001207
type: ChemicalStructure
structure format: SMILES

Compound/PW C000504 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Galactose 1-phosphate
stoichiometric coefficient: 1.0

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

ChemicalStructure/PW C000119
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

Reference/HMDB HMDB0000122
type: UnificationXref
id: HMDB0000122
db: HMDB

3.6.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000201 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000194 Golgi Apparatus/Stoichiometry/1.0
right: Phosphoric acid
right: Uridine 5'-monophosphate
spontaneous: false
EC number: 3.6.1.6
left: Uridine 5'-diphosphate
left: Water
name: Uridine 5'-diphosphate + Water → Phosphoric acid + Uridine 5'-monophosphate
conversion direction: LEFT_TO_RIGHT

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

ReactionCatalysis516
type: Catalysis
controller: Nucleoside diphosphate kinase B
controlled: Reaction402
control type: ACTIVATION

ReactionCatalysis513
type: Catalysis
controller: Glucose-6-phosphatase
controlled: 3.1.3.9
control type: ACTIVATION

TransportCatalysis19
type: Catalysis
controller: UDP-galactose translocator
controlled: Transport46
control type: ACTIVATION

TransportCatalysis18
type: Catalysis
controller: Solute carrier family 2, facilitated glucose transporter member 1
controlled: Transport45
control type: ACTIVATION

ReactionCatalysis552
type: Catalysis
controller: Soluble calcium-activated nucleotidase 1
controlled: 3.6.1.6
control type: ACTIVATION

UTP--glucose-1-phosphate uridylyltransferase
type: Protein
cellular location: Cytosol
entity reference: UTP--glucose-1-phosphate uridylyltransferase

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/KEGG Compound C00031
type: UnificationXref
id: C00031
db: KEGG Compound

Reference/BioCyc UDP
type: UnificationXref
id: UDP
db: BioCyc

Reference/ChemSpider 76293
type: UnificationXref
id: 76293
db: ChemSpider

Reference/HMDB HMDB0001586
type: UnificationXref
id: HMDB0001586
db: HMDB

Reference/PubChem-compound 123912
type: UnificationXref
id: 123912
db: PubChem-compound

D-Glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: D-Glucose

Protein/369 Golgi Apparatus/Stoichiometry/2.0
type: Stoichiometry
physical entity: Beta-1,4-galactosyltransferase 1
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

3.1.3.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001207 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: D-Glucose
spontaneous: false
EC number: 3.1.3.9
left: Glucose 1-phosphate
left: Water
name: Glucose 1-phosphate + Water → D-Glucose + Phosphate
conversion direction: LEFT_TO_RIGHT

α-Lactose
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: α-Lactose

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/CAS 58-97-9
type: UnificationXref
id: 58-97-9
db: CAS

Compound/PW C000193 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate glucose
stoichiometric coefficient: 1.0

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Reference/KEGG Compound C00052
type: UnificationXref
id: C00052
db: KEGG Compound

Golgi Apparatus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005794

Uridine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17659
xref: Reference/PubChem-compound 6031
xref: Reference/CAS 58-98-0
xref: Reference/HMDB HMDB0000295
xref: Reference/KEGG Compound C00015
xref: Reference/ChemSpider 5809
xref: Reference/BioCyc UDP
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C000201

Soluble calcium-activated nucleotidase 1
type: ProteinReference
xref: Reference/UniProt Q8WVQ1
organism: Homo sapiens

Uridine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine triphosphate

Protein/1026 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Galactose-1-phosphate uridylyltransferase
stoichiometric coefficient: 2.0

Reference/GENE ONTOLOGY GO 0005794
type: UnificationXref
id: GO:0005794
db: GENE ONTOLOGY

Lactose Synthesis
type: Pathway
pathway order: PathwayTransport/756
pathway order: PathwayEnzymeReaction/706
pathway order: PathwayEnzymeReaction/711
pathway order: PathwayTransport/725
pathway order: PathwayEnzymeReaction/751
pathway order: PathwayEnzymeReaction/720
pathway order: PathwayEnzymeReaction/730
pathway order: PathwayEnzymeReaction/718
pathway order: PathwayEnzymeReaction/709
pathway component: 2.7.7.9
pathway component: ReactionCatalysis531
pathway component: 3.1.3.9
pathway component: TransportCatalysis19
pathway component: ReactionCatalysis376
pathway component: TransportCatalysis18
pathway component: ReactionCatalysis552
pathway component: Transport46
pathway component: Transport45
pathway component: Reaction196
pathway component: 3.6.1.6
pathway component: 2.7.7.12
pathway component: Reaction940
pathway component: Reaction402
pathway component: ReactionCatalysis516
pathway component: ReactionCatalysis513
pathway component: ReactionCatalysis379
pathway component: ReactionCatalysis523
xref: Reference/PathWhiz PW000049
xref: Reference/SMPDB SMP0000444
organism: Homo sapiens

Reference/BioCyc UTP
type: UnificationXref
id: UTP
db: BioCyc

Compound/PW C000201 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5903
type: UnificationXref
id: 5903
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Compound/PW C001441 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 5589
type: UnificationXref
id: 5589
db: ChemSpider

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Transport46
type: Transport
participant stoichiometry: Compound/PW C000194 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000206 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000206 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000194 Golgi Apparatus/Stoichiometry/1.0
right: Uridine 5'-monophosphate
right: Uridine diphosphategalactose
spontaneous: false
left: Uridine 5'-monophosphate
left: Uridine diphosphategalactose
name: Uridine diphosphategalactose (→), Uridine 5'-monophosphate (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Golgi Apparatus
conversion direction: LEFT_TO_RIGHT

Transport45
type: Transport
participant stoichiometry: Compound/PW C000077 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Golgi Apparatus/Stoichiometry/1.0
right: D-Glucose
spontaneous: false
left: D-Glucose
name: D-Glucose (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Golgi Apparatus
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 18068
type: UnificationXref
id: 18068
db: PubChem-compound

Reference/ChEBI CHEBI 16077
type: UnificationXref
id: CHEBI:16077
db: ChEBI

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Galactose-1-phosphate uridylyltransferase
type: Protein
cellular location: Cytosol
entity reference: Galactose-1-phosphate uridylyltransferase

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 110443
type: UnificationXref
id: 110443
db: ChemSpider

Protein/364 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Alpha-lactalbumin
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

2.7.7.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000192 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000193 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001207 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: Pyrophosphate
right: Uridine diphosphate glucose
spontaneous: false
EC number: 2.7.7.9
left: Glucose 1-phosphate
left: Uridine triphosphate
name: Glucose 1-phosphate + Uridine triphosphate → Pyrophosphate + Uridine diphosphate glucose
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 17973
type: UnificationXref
id: CHEBI:17973
db: ChEBI

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Water
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Water

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/HMDB HMDB0000288
type: UnificationXref
id: HMDB0000288
db: HMDB

Reference/ChemSpider 17069
type: UnificationXref
id: 17069
db: ChemSpider

Solute carrier family 2, facilitated glucose transporter member 1
type: Protein
entity reference: Solute carrier family 2, facilitated glucose transporter member 1

Reaction940
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000201 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000077 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000206 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000119 Golgi Apparatus/Stoichiometry/1.0
right: Uridine 5'-diphosphate
right: α-Lactose
spontaneous: false
left: D-Glucose
left: Uridine diphosphategalactose
name: D-Glucose + Uridine diphosphategalactose → Uridine 5'-diphosphate + α-Lactose
conversion direction: LEFT_TO_RIGHT

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000286
type: UnificationXref
id: HMDB0000286
db: HMDB

Reference/HMDB HMDB0000285
type: UnificationXref
id: HMDB0000285
db: HMDB

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Uridine diphosphate glucose
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine diphosphate glucose

Reference/CAS 58-98-0
type: UnificationXref
id: 58-98-0
db: CAS

Reference/KEGG Compound C00075
type: UnificationXref
id: C00075
db: KEGG Compound

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

Reference/ChEBI CHEBI 16695
type: UnificationXref
id: CHEBI:16695
db: ChEBI

Compound/PW C000206 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphategalactose
stoichiometric coefficient: 1.0

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Reference/UniProt P11166
type: UnificationXref
id: P11166
db: UniProt

Reference/SMPDB SMP0000444
type: UnificationXref
id: SMP0000444
db: SMPDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0000295
type: UnificationXref
id: HMDB0000295
db: HMDB

Reference/ChemSpider 5809
type: UnificationXref
id: 5809
db: ChemSpider

Reference/UniProt P07902
type: UnificationXref
id: P07902
db: UniProt

Reference/ChemSpider 5808
type: UnificationXref
id: 5808
db: ChemSpider

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

α-Lactose
type: SmallMoleculeReference
xref: Reference/PubChem-compound 84571
xref: Reference/CAS 63-42-3
xref: Reference/BioCyc LACTOSE
xref: Reference/ChEBI CHEBI 36219
xref: Reference/KEGG Compound C00243
xref: Reference/HMDB HMDB0000186
xref: Reference/ChemSpider 76293
chemical formula: C12H22O11
molecular weight: 342.1162
structure: ChemicalStructure/PW C000119

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Glucose 1-phosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001586
xref: Reference/PubChem-compound 439165
xref: Reference/CAS 59-56-3
xref: Reference/BioCyc GLC-1-P
xref: Reference/ChEBI CHEBI 16077
xref: Reference/KEGG Compound C00103
xref: Reference/ChemSpider 388311
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C001207

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Reference/ChEBI CHEBI 4167
type: UnificationXref
id: CHEBI:4167
db: ChEBI

Reference/CAS 2255-14-3
type: UnificationXref
id: 2255-14-3
db: CAS

Beta-1,4-galactosyltransferase 1
type: Protein
cellular location: Golgi Apparatus
entity reference: Beta-1,4-galactosyltransferase 1

Soluble calcium-activated nucleotidase 1
type: Protein
cellular location: Golgi Apparatus
entity reference: Soluble calcium-activated nucleotidase 1

Reference/HMDB HMDB0000186
type: UnificationXref
id: HMDB0000186
db: HMDB

Reference/PubChem-compound 5793
type: UnificationXref
id: 5793
db: PubChem-compound

ReactionCatalysis376
type: Catalysis
controller: UTP--glucose-1-phosphate uridylyltransferase
controlled: 2.7.7.9
control type: ACTIVATION

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Uridine diphosphategalactose
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 67119
xref: Reference/ChemSpider 17069
xref: Reference/KEGG Compound C00052
xref: Reference/HMDB HMDB0000302
xref: Reference/PubChem-compound 18068
xref: Reference/CAS 2956-16-3
xref: Reference/BioCyc UDP-GLACTOSE
chemical formula: C15H24N2O17P2
molecular weight: 566.055
structure: ChemicalStructure/PW C000206

UMP-CMP kinase
type: Protein
cellular location: Cytosol
entity reference: UMP-CMP kinase

UDP-galactose translocator
type: Protein
entity reference: UDP-galactose translocator

ChemicalStructure/PW C000504
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000077
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000194
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000193
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000192
type: ChemicalStructure
structure format: SMILES

Nucleoside diphosphate kinase B
type: Protein
cellular location: Cytosol
entity reference: Nucleoside diphosphate kinase B

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/CAS 63-39-8
type: UnificationXref
id: 63-39-8
db: CAS

Reference/UniProt Q16851
type: UnificationXref
id: Q16851
db: UniProt

Reference/ChEBI CHEBI 17659
type: UnificationXref
id: CHEBI:17659
db: ChEBI

Reference/BioCyc UMP
type: UnificationXref
id: UMP
db: BioCyc

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Uridine 5'-diphosphate

Compound/PW C001207 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucose 1-phosphate
stoichiometric coefficient: 1.0

Protein/1008 Cytosol/Stoichiometry/8.0
type: Stoichiometry
physical entity: UTP--glucose-1-phosphate uridylyltransferase
stoichiometric coefficient: 8.0

Reference/HMDB HMDB0000645
type: UnificationXref
id: HMDB0000645
db: HMDB

D-Glucose
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: D-Glucose

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB