Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

Acetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15366
xref: Reference/BioCyc ACET
xref: Reference/CAS 64-19-7
xref: Reference/KEGG Compound C00033
xref: Reference/ChemSpider 171
xref: Reference/HMDB HMDB0000042
xref: Reference/PubChem-compound 176
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C000029

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine triphosphate

Cytochrome P450 2E1
type: ProteinReference
xref: Reference/UniProt P05181
organism: BiologicalState10

Acetaldehyde
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetaldehyde

Compound/PW C000784 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetaldehyde
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

ReactionCatalysis1449
type: Catalysis
controller: Aldehyde dehydrogenase X, mitochondrial
controlled: 1.2.1.3
control type: ACTIVATION

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Reference/CAS 64-19-7
type: UnificationXref
id: 64-19-7
db: CAS

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Ethanol
type: SmallMolecule
cellular location: Peroxisome
entity reference: Ethanol

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

Compound/PW C000070 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ethanol
stoichiometric coefficient: 1.0

Protein/289 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Aldehyde dehydrogenase, mitochondrial
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

NADPH
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADPH

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/UniProt P04040
type: UnificationXref
id: P04040
db: UniProt

Acetaldehyde
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetaldehyde

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Reference/ChEBI CHEBI 16236
type: UnificationXref
id: CHEBI:16236
db: ChEBI

Reference/PubChem-compound 702
type: UnificationXref
id: 702
db: PubChem-compound

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Alcohol dehydrogenase 1B
type: ProteinReference
xref: Reference/UniProt P00325
organism: Homo sapiens

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

1.1.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000070 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000784 Cytoplasm/Stoichiometry/1.0
right: Hydrogen Ion
right: NADH
right: Acetaldehyde
spontaneous: false
EC number: 1.1.1.1
left: Ethanol
left: NAD
name: Ethanol + NAD → Acetaldehyde + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Aldehyde dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P05091
organism: Homo sapiens

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Compound/PW C000029 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00469
type: UnificationXref
id: C00469
db: KEGG Compound

Adenosine monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine monophosphate

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Compound/PW C000784 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetaldehyde
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Acetic acid
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetic acid

Alcohol dehydrogenase 1B
type: Protein
cellular location: Cytoplasm
entity reference: Alcohol dehydrogenase 1B

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Aldehyde dehydrogenase X, mitochondrial
type: ProteinReference
xref: Reference/UniProt P30837
organism: Homo sapiens

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Acetyl-CoA
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetyl-CoA

Alcohol dehydrogenase 1B
type: Complex
component stoichiometry: Protein/727 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Alcohol dehydrogenase 1B

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Compound/PW C040034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Catalase
type: Protein
cellular location: Peroxisome
entity reference: Catalase

Aldehyde dehydrogenase X, mitochondrial
type: Complex
component stoichiometry: Protein/291 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Aldehyde dehydrogenase X, mitochondrial

Water
type: SmallMolecule
cellular location: Peroxisome
entity reference: Water

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Catalase
type: ProteinReference
xref: Reference/UniProt P04040
organism: Homo sapiens

Reference/BioCyc ETOH
type: UnificationXref
id: ETOH
db: BioCyc

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Ethanol
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00469
xref: Reference/ChEBI CHEBI 16236
xref: Reference/PubChem-compound 702
xref: Reference/ChemSpider 682
xref: Reference/HMDB HMDB0000108
xref: Reference/CAS 64-17-5
xref: Reference/BioCyc ETOH
chemical formula: C2H6O
molecular weight: 46.041866
structure: ChemicalStructure/PW C000070

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Adenosine monophosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Adenosine monophosphate

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

1.11.1.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000784 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Peroxisome/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000070 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001783 Peroxisome/Stoichiometry/1.0
right: Acetaldehyde
right: Water
spontaneous: false
EC number: 1.11.1.6
left: Hydrogen peroxide
left: Ethanol
name: Ethanol + Hydrogen peroxide → Acetaldehyde + 2 Water
conversion direction: LEFT_TO_RIGHT

Acetyl-coenzyme A synthetase, cytoplasmic
type: ProteinReference
xref: Reference/UniProt Q9NR19
organism: Homo sapiens

6.2.1.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000029 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000029 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
right: Adenosine monophosphate
right: Acetyl-CoA
right: Pyrophosphate
spontaneous: false
EC number: 6.2.1.1
left: Acetic acid
left: Coenzyme A
left: Adenosine triphosphate
name: Acetic acid + Adenosine triphosphate + Coenzyme A → Acetyl-CoA + Adenosine monophosphate + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Oxygen
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Oxygen

Reaction727
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000784 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000070 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Water
right: Acetaldehyde
right: NADP
spontaneous: false
left: Oxygen
left: Ethanol
left: NADPH
name: Ethanol + NADPH + Oxygen → Acetaldehyde + NADP + Water
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Compound/PW C000070 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ethanol
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

NADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADH

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Pyrophosphate
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Pyrophosphate

Reference/ChemSpider 682
type: UnificationXref
id: 682
db: ChemSpider

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme A

Reference/UniProt P00325
type: UnificationXref
id: P00325
db: UniProt

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Hydrogen peroxide
type: SmallMolecule
cellular location: Peroxisome
entity reference: Hydrogen peroxide

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0000108
type: UnificationXref
id: HMDB0000108
db: HMDB

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen Ion

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Cytochrome P450 2E1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Cytochrome P450 2E1

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Compound/PW C000143 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Acetaldehyde
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Acetaldehyde

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Protein/727 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Alcohol dehydrogenase 1B
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Compound/PW C000029 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

Reference/BioCyc ACET
type: UnificationXref
id: ACET
db: BioCyc

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Coenzyme A

Acetaldehyde
type: SmallMolecule
cellular location: Peroxisome
entity reference: Acetaldehyde

Compound/PW C000170 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

Reference/UniProt Q9NR19
type: UnificationXref
id: Q9NR19
db: UniProt

NADH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADH

Reference/KEGG Compound C00033
type: UnificationXref
id: C00033
db: KEGG Compound

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Transport20
type: Transport
participant stoichiometry: Compound/PW C000029 Cytoplasm/Stoichiometry/1.0
right: Acetic acid
spontaneous: false
left: Acetic acid
name: Acetic acid (→) Transport: Homo sapiens, Liver, Cell, Cytoplasm to Homo sapiens, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Compound/PW C000414 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Peroxisome
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005777

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Compound/PW C001420 Peroxisome/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Compound/PW C000784 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetaldehyde
stoichiometric coefficient: 1.0

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Compound/PW C000784 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetaldehyde
stoichiometric coefficient: 1.0

Transport17
type: Transport
participant stoichiometry: Compound/PW C000784 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000784 Cytoplasm/Stoichiometry/1.0
right: Acetaldehyde
spontaneous: false
left: Acetaldehyde
name: Acetaldehyde (→) Transport: Homo sapiens, Liver, Cell, Endoplasmic Reticulum Lumen to Homo sapiens, Liver, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Transport18
type: Transport
participant stoichiometry: Compound/PW C000070 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000070 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
right: Ethanol
spontaneous: false
left: Ethanol
name: Ethanol (→) Transport: Homo sapiens, Liver, Cell, Cytoplasm to Homo sapiens, Liver, Cell, Endoplasmic Reticulum Lumen
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P05091
type: UnificationXref
id: P05091
db: UniProt

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/UniProt P30837
type: UnificationXref
id: P30837
db: UniProt

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Ethanol Degradation
type: Pathway
pathway order: PathwayTransport/305
pathway order: PathwayEnzymeReaction/308
pathway order: PathwayTransport/304
pathway order: PathwayEnzymeReaction/309
pathway order: PathwayEnzymeReaction/306
pathway order: PathwayTransport/307
pathway order: PathwayEnzymeReaction/300
pathway order: PathwayEnzymeReaction/302
pathway order: PathwayEnzymeReaction/2013
pathway order: PathwayEnzymeReaction/301
pathway component: 1.11.1.6
pathway component: 6.2.1.1
pathway component: ReactionCatalysis243
pathway component: Reaction727
pathway component: ReactionCatalysis244
pathway component: ReactionCatalysis241
pathway component: Transport17
pathway component: ReactionCatalysis242
pathway component: ReactionCatalysis240
pathway component: Transport18
pathway component: Transport20
pathway component: 1.1.1.1
pathway component: ReactionCatalysis1449
pathway component: 1.2.1.3
pathway component: ReactionCatalysis239
xref: Reference/SMPDB SMP0000449
xref: Reference/PathWhiz PW000021
organism: Homo sapiens

1.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000029 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000784 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetic acid
right: NADH
right: Hydrogen Ion
spontaneous: false
EC number: 1.2.1.3
left: Water
left: Acetaldehyde
left: NAD
name: Acetaldehyde + NAD + Water → Acetic acid + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Ethanol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Ethanol

Compound/PW C000940 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Acetyl-coenzyme A synthetase, cytoplasmic
type: Protein
cellular location: Cytoplasm
entity reference: Acetyl-coenzyme A synthetase, cytoplasmic

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Acetyl-coenzyme A synthetase 2-like, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9NUB1
organism: Homo sapiens

Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ChemicalStructure/PW C000029
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=O

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Hydrogen Ion
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen Ion

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Protein/1470 Peroxisome/Stoichiometry/4.0
type: Stoichiometry
physical entity: Catalase
stoichiometric coefficient: 4.0

Compound/PW C000032 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Compound/PW C000784 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetaldehyde
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005788
type: UnificationXref
id: GO:0005788
db: GENE ONTOLOGY

Ethanol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Ethanol

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

BiologicalState10
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver
tissue: Liver

NAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NAD

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Acetaldehyde
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15343
xref: Reference/KEGG Compound C00084
xref: Reference/CAS 75-07-0
xref: Reference/BioCyc ACETALD
xref: Reference/ChemSpider 172
xref: Reference/PubChem-compound 177
xref: Reference/HMDB HMDB0000990
chemical formula: C2H4O
molecular weight: 44.026215
structure: ChemicalStructure/PW C000784

Acetaldehyde
type: SmallMolecule
cellular location: Endoplasmic Reticulum Lumen
entity reference: Acetaldehyde

Reference/GENE ONTOLOGY GO 0005777
type: UnificationXref
id: GO:0005777
db: GENE ONTOLOGY

Reference/HMDB HMDB0000042
type: UnificationXref
id: HMDB0000042
db: HMDB

Acetyl-coenzyme A synthetase 2-like, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Acetyl-coenzyme A synthetase 2-like, mitochondrial

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/ChEBI CHEBI 15366
type: UnificationXref
id: CHEBI:15366
db: ChEBI

Reference/SMPDB SMP0000449
type: UnificationXref
id: SMP0000449
db: SMPDB

Reference/PathWhiz PW000021
type: UnificationXref
id: PW000021
db: PathWhiz

Endoplasmic Reticulum Lumen
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005788

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/CAS 64-17-5
type: UnificationXref
id: 64-17-5
db: CAS

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Water
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Water

Reference/KEGG Compound C00084
type: UnificationXref
id: C00084
db: KEGG Compound

Aldehyde dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Aldehyde dehydrogenase, mitochondrial

Reference/CAS 75-07-0
type: UnificationXref
id: 75-07-0
db: CAS

Reference/ChemSpider 172
type: UnificationXref
id: 172
db: ChemSpider

Reference/ChemSpider 171
type: UnificationXref
id: 171
db: ChemSpider

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Compound/PW C000032 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/BioCyc ACETALD
type: UnificationXref
id: ACETALD
db: BioCyc

Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000784
type: ChemicalStructure
structure format: SMILES
structure data: CC=O

Aldehyde dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/289 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Aldehyde dehydrogenase, mitochondrial

Reference/ChEBI CHEBI 15343
type: UnificationXref
id: CHEBI:15343
db: ChEBI

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Aldehyde dehydrogenase X, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Aldehyde dehydrogenase X, mitochondrial

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Reference/UniProt Q9NUB1
type: UnificationXref
id: Q9NUB1
db: UniProt

Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/UniProt P05181
type: UnificationXref
id: P05181
db: UniProt

Ethanol
type: SmallMolecule
cellular location: Endoplasmic Reticulum Lumen
entity reference: Ethanol

Compound/PW C001783 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Acetic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Acetic acid

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Compound/PW C000070 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ethanol
stoichiometric coefficient: 1.0

Protein/291 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Aldehyde dehydrogenase X, mitochondrial
stoichiometric coefficient: 4.0

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/HMDB HMDB0000990
type: UnificationXref
id: HMDB0000990
db: HMDB

ChemicalStructure/PW C000070
type: ChemicalStructure
structure format: SMILES
structure data: CCO

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

NADP
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: NADP

ReactionCatalysis243
type: Catalysis
controller: Acetyl-coenzyme A synthetase, cytoplasmic
controlled: 6.2.1.1
control type: ACTIVATION

ReactionCatalysis244
type: Catalysis
controller: Acetyl-coenzyme A synthetase 2-like, mitochondrial
controlled: 6.2.1.1
control type: ACTIVATION

ReactionCatalysis241
type: Catalysis
controller: Cytochrome P450 2E1
controlled: Reaction727
control type: ACTIVATION

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

ReactionCatalysis242
type: Catalysis
controller: Catalase
controlled: 1.11.1.6
control type: ACTIVATION

ReactionCatalysis240
type: Catalysis
controller: Aldehyde dehydrogenase, mitochondrial
controlled: 1.2.1.3
control type: ACTIVATION

Reference/PubChem-compound 177
type: UnificationXref
id: 177
db: PubChem-compound

Compound/PW C000070 Endoplasmic Reticulum Lumen/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ethanol
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

Reference/PubChem-compound 176
type: UnificationXref
id: 176
db: PubChem-compound

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

NAD
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NAD

ReactionCatalysis239
type: Catalysis
controller: Alcohol dehydrogenase 1B
controlled: 1.1.1.1
control type: ACTIVATION

Catalase
type: Complex
component stoichiometry: Protein/1470 Peroxisome/Stoichiometry/4.0
cellular location: Peroxisome
component: Catalase