SubPathwayInteraction398
type: Interaction
name: SubPathway398Reaction
name: SubPathwayReaction
participant: Stearic acid

SubPathwayInteraction399
type: Interaction
name: SubPathwayReaction
name: SubPathway399Reaction
participant: Stearic acid

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/KEGG Compound C00318
type: UnificationXref
id: C00318
db: KEGG Compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

L-Carnitine
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: L-Carnitine

Trifunctional enzyme subunit alpha, mitochondrial
type: ProteinReference
xref: Reference/UniProt P40939
organism: Homo sapiens

Enoyl-CoA hydratase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P30084
organism: Homo sapiens

Compound/PW C000032 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine monophosphate
stoichiometric coefficient: 1.0

Trifunctional enzyme subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Trifunctional enzyme subunit beta, mitochondrial

Reference/CAS 25597-09-5
type: UnificationXref
id: 25597-09-5
db: CAS

Lauroyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc LAUROYLCOA-CPD
xref: Reference/KEGG Compound C01832
xref: Reference/ChEBI CHEBI 15521
xref: Reference/HMDB HMDB0003571
xref: Reference/CAS 6244-92-4
xref: Reference/ChemSpider 145018
xref: Reference/PubChem-compound 165436
chemical formula: C33H58N7O17P3S
molecular weight: 949.2823
structure: ChemicalStructure/PW C001928

Reference/ChEBI CHEBI 16027
type: UnificationXref
id: CHEBI:16027
db: ChEBI

Reference/PubChem-compound 53481913
type: UnificationXref
id: 53481913
db: PubChem-compound

Reference/CAS 38795-33-4
type: UnificationXref
id: 38795-33-4
db: CAS

Reference/PubChem-compound 5281
type: UnificationXref
id: 5281
db: PubChem-compound

Reference/KEGG Compound C01530
type: UnificationXref
id: C01530
db: KEGG Compound

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PathWhiz PW000173
type: UnificationXref
id: PW000173
db: PathWhiz

Reference/ChemSpider 388366
type: UnificationXref
id: 388366
db: ChemSpider

Reference/PathWhiz PW000172
type: UnificationXref
id: PW000172
db: PathWhiz

Reference/HMDB HMDB0006529
type: UnificationXref
id: HMDB0006529
db: HMDB

Mitochondrial carnitine/acylcarnitine carrier protein
type: Protein
entity reference: Mitochondrial carnitine/acylcarnitine carrier protein

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Transport129
type: Transport
participant stoichiometry: Compound/PW C000675 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000675 Mitochondrial Matrix/Stoichiometry/1.0
right: Stearoylcarnitine
spontaneous: false
left: Stearoylcarnitine
name: Stearoylcarnitine (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Compound/PW C002010 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Tetradecenoyl-CoA
stoichiometric coefficient: 1.0

Transport128
type: Transport
participant stoichiometry: Compound/PW C000044 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044 Mitochondrial Matrix/Stoichiometry/1.0
right: L-Carnitine
spontaneous: false
left: L-Carnitine
name: L-Carnitine (→) Transport: Homo sapiens, Cell, Mitochondrial Matrix to Homo sapiens, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Compound/PW C000675 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Stearoylcarnitine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0006402
type: UnificationXref
id: HMDB0006402
db: HMDB

Reference/PathWhiz PW000167
type: UnificationXref
id: PW000167
db: PathWhiz

Tetradecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Tetradecanoyl-CoA

3-Hydroxytetradecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: 3-Hydroxytetradecanoyl-CoA

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Compound/PW C002009 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Hexadecenoyl-CoA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 11966197
type: UnificationXref
id: 11966197
db: PubChem-compound

Compound/PW C001031 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitoyl-CoA
stoichiometric coefficient: 1.0

Trifunctional enzyme, mitochondrial
type: Complex
component stoichiometry: Protein/46 Mitochondrial Matrix/Stoichiometry/4.0
component stoichiometry: Protein/381 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Trifunctional enzyme subunit alpha, mitochondrial
component: Trifunctional enzyme subunit beta, mitochondrial

L-Carnitine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Carnitine

Reference/ChemSpider 5858
type: UnificationXref
id: 5858
db: ChemSpider

Stearoyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Stearoyl-CoA

Lauroyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Lauroyl-CoA

Compound/PW C002796 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Octadecenoyl-CoA
stoichiometric coefficient: 1.0

Stearic acid
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Stearic acid

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Enoyl-CoA hydratase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Enoyl-CoA hydratase, mitochondrial

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Tetradecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Tetradecanoyl-CoA

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

(2E)-Octadecenoyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: (2E)-Octadecenoyl-CoA

Trifunctional enzyme, mitochondrial
type: Complex
component stoichiometry: Protein/381 Mitochondrial Inner Membrane/Stoichiometry/4.0
component stoichiometry: Protein/46 Mitochondrial Inner Membrane/Stoichiometry/4.0
cellular location: Mitochondrial Inner Membrane
component: Trifunctional enzyme subunit beta, mitochondrial
component: Trifunctional enzyme subunit alpha, mitochondrial

Reference/ChEBI CHEBI 5086
type: UnificationXref
id: CHEBI:5086
db: ChEBI

Reference/BioCyc LAUROYLCOA-CPD
type: UnificationXref
id: LAUROYLCOA-CPD
db: BioCyc

Lauroyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Lauroyl-CoA
name: SubPathwayInput

Compound/Generic70 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Reduced electron-transfer flavoprotein
stoichiometric coefficient: 1.0

Long-chain-fatty-acid--CoA ligase 1
type: Protein
cellular location: Mitochondrial Outer Membrane
entity reference: Long-chain-fatty-acid--CoA ligase 1

Stearoylcarnitine
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Stearoylcarnitine

Stearoyl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 362-66-3
xref: Reference/ChEBI CHEBI 15541
xref: Reference/HMDB HMDB0001114
xref: Reference/KEGG Compound C00412
xref: Reference/BioCyc STEAROYL-COA
xref: Reference/ChemSpider 388366
xref: Reference/PubChem-compound 439229
chemical formula: C39H70N7O17P3S
molecular weight: 1033.3762
structure: ChemicalStructure/PW C000871

Reference/PubChem-compound 53477850
type: UnificationXref
id: 53477850
db: PubChem-compound

3-ketoacyl-CoA thiolase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P42765
organism: Homo sapiens

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Long-chain specific acyl-CoA dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Long-chain specific acyl-CoA dehydrogenase, mitochondrial

NADH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADH

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/UniProt P42765
type: UnificationXref
id: P42765
db: UniProt

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Coenzyme A

Mitochondrial Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005743

L-Carnitine
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: L-Carnitine

Compound/PW C001171 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetradecanoyl-CoA
stoichiometric coefficient: 1.0

Reference/CAS 3130-72-1
type: UnificationXref
id: 3130-72-1
db: CAS

Reference/ChemSpider 389500
type: UnificationXref
id: 389500
db: ChemSpider

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

(2E)-Octadecenoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: (2E)-Octadecenoyl-CoA

Stearoylcarnitine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Stearoylcarnitine

Reference/UniProt P28330
type: UnificationXref
id: P28330
db: UniProt

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/BioCyc CARNITINE
type: UnificationXref
id: CARNITINE
db: BioCyc

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00020
type: UnificationXref
id: C00020
db: KEGG Compound

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

Carnitine O-palmitoyltransferase 1
type: Complex
component stoichiometry: Protein/303 Mitochondrial Outer Membrane/Stoichiometry/6.0
cellular location: Mitochondrial Outer Membrane
component: Carnitine O-palmitoyltransferase 1, liver isoform

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Trifunctional enzyme subunit beta, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Trifunctional enzyme subunit beta, mitochondrial

ChemicalStructure/PW C008527
type: ChemicalStructure
structure format: SMILES

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q16836
organism: Homo sapiens

Adenosine monophosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Adenosine monophosphate

Reference/CAS 4460-95-1
type: UnificationXref
id: 4460-95-1
db: CAS

Stearic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Stearic acid
name: SubPathwayOutput

Stearoylcarnitine
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Stearoylcarnitine

3-oxooctadecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: 3-oxooctadecanoyl-CoA

3-oxohexadecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-oxohexadecanoyl-CoA

Reference/KEGG Compound C00154
type: UnificationXref
id: C00154
db: KEGG Compound

3-Hydroxyhexadecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27402
xref: Reference/HMDB HMDB0003932
xref: Reference/CAS 35106-50-4
xref: Reference/ChemSpider 389498
xref: Reference/PubChem-compound 440600
xref: Reference/KEGG Compound C05258
chemical formula: C37H66N7O18P3S
molecular weight: 1021.3398
structure: ChemicalStructure/PW C001996

3-Hydroxytetradecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 27466
xref: Reference/ChemSpider 389500
xref: Reference/HMDB HMDB0003934
xref: Reference/KEGG Compound C05260
xref: Reference/PubChem-compound 440602
chemical formula: C35H62N7O18P3S
molecular weight: 993.3085
structure: ChemicalStructure/PW C001998

Carnitine O-palmitoyltransferase 1, liver isoform
type: ProteinReference
xref: Reference/UniProt P50416
organism: Homo sapiens

3-oxotetradecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 11966197
xref: Reference/HMDB HMDB0003935
xref: Reference/ChemSpider 10140190
xref: Reference/KEGG Compound C05261
xref: Reference/ChEBI CHEBI 28726
xref: Reference/CAS 122364-86-7
chemical formula: C35H60N7O18P3S
molecular weight: 991.29285
structure: ChemicalStructure/PW C001999

Carnitine O-palmitoyltransferase 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt P23786
organism: Homo sapiens

Long-chain-fatty-acid--CoA ligase 1
type: ProteinReference
xref: Reference/UniProt P33121
organism: Homo sapiens

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc AMP
type: UnificationXref
id: AMP
db: BioCyc

Reference/CAS 35106-50-4
type: UnificationXref
id: 35106-50-4
db: CAS

Reference/BioCyc STEARIC ACID
type: UnificationXref
id: STEARIC_ACID
db: BioCyc

Tetradecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Tetradecanoyl-CoA

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Compound/PW C002775 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-oxooctadecanoyl-CoA
stoichiometric coefficient: 1.0

Stearoylcarnitine
type: SmallMoleculeReference
xref: Reference/PubChem-compound 52922056
xref: Reference/HMDB HMDB0000848
xref: Reference/CAS 25597-09-5
xref: Reference/ChEBI CHEBI 84644
chemical formula: C25H49NO4
molecular weight: 427.36615
structure: ChemicalStructure/PW C000675

(2E)-Octadecenoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: (2E)-Octadecenoyl-CoA

Reference/HMDB HMDB0001114
type: UnificationXref
id: HMDB0001114
db: HMDB

ChemicalStructure/PW C001031
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C02593
type: UnificationXref
id: C02593
db: KEGG Compound

3-oxohexadecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 34619-89-1
xref: Reference/HMDB HMDB0006402
xref: Reference/ChEBI CHEBI 15491
xref: Reference/ChemSpider 389499
xref: Reference/PubChem-compound 440601
xref: Reference/KEGG Compound C05259
xref: Reference/BioCyc 3-OXOPALMITOYL-COA
chemical formula: C37H64N7O18P3S
molecular weight: 1019.32416
structure: ChemicalStructure/PW C002740

Compound/PW C040034 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Protein/381 Mitochondrial Inner Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Trifunctional enzyme subunit alpha, mitochondrial
stoichiometric coefficient: 4.0

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Acetyl-CoA

Reference/BioCyc 3-OXOPALMITOYL-COA
type: UnificationXref
id: 3-OXOPALMITOYL-COA
db: BioCyc

Reference/CAS 61-19-8
type: UnificationXref
id: 61-19-8
db: CAS

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

ChemicalStructure/PW C000032
type: ChemicalStructure
structure format: SMILES

Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

3-oxooctadecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-oxooctadecanoyl-CoA

Reference/UniProt O43772
type: UnificationXref
id: O43772
db: UniProt

Compound/PW C001928 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lauroyl-CoA
stoichiometric coefficient: 1.0

Compound/Generic69 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: electron-transfer flavoprotein
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Stearoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Stearoyl-CoA

Reference/PubChem-compound 165436
type: UnificationXref
id: 165436
db: PubChem-compound

NAD
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NAD

ChemicalStructure/PW C000044
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)C[C@H](O)CC([O-])=O

Reference/HMDB HMDB0000045
type: UnificationXref
id: HMDB0000045
db: HMDB

Compound/PW C000044 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

Stearic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 28842
xref: Reference/PubChem-compound 5281
xref: Reference/ChemSpider 5091
xref: Reference/KEGG Compound C01530
xref: Reference/BioCyc STEARIC ACID
xref: Reference/HMDB HMDB0000827
xref: Reference/CAS 57-11-4
chemical formula: C18H36O2
molecular weight: 284.27155
structure: ChemicalStructure/PW C000661

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Adenosine triphosphate

Reference/PubChem-compound 22833663
type: UnificationXref
id: 22833663
db: PubChem-compound

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

Reference/UniProt P50416
type: UnificationXref
id: P50416
db: UniProt

Water
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Water

3-oxooctadecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/ChemSpider 17216373
xref: Reference/HMDB HMDB0006498
xref: Reference/KEGG Compound C16216
xref: Reference/CAS 86370-20-9
xref: Reference/PubChem-compound 22833663
chemical formula: C39H68N7O18P3S
molecular weight: 1047.3555
structure: ChemicalStructure/PW C002775

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Hydrogen Ion

Enoyl-CoA hydratase, mitochondrial
type: Complex
component stoichiometry: Protein/380 Mitochondrial Matrix/Stoichiometry/6.0
cellular location: Mitochondrial Matrix
component: Enoyl-CoA hydratase, mitochondrial

Compound/PW C001928 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lauroyl-CoA
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/CAS 57-11-4
type: UnificationXref
id: 57-11-4
db: CAS

Protein/303 Mitochondrial Outer Membrane/Stoichiometry/6.0
type: Stoichiometry
physical entity: Carnitine O-palmitoyltransferase 1, liver isoform
stoichiometric coefficient: 6.0

Compound/PW C001099 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Protein/380 Mitochondrial Matrix/Stoichiometry/6.0
type: Stoichiometry
physical entity: Enoyl-CoA hydratase, mitochondrial
stoichiometric coefficient: 6.0

Compound/PW C002009 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Hexadecenoyl-CoA
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003571
type: UnificationXref
id: HMDB0003571
db: HMDB

Reference/HMDB HMDB0000062
type: UnificationXref
id: HMDB0000062
db: HMDB

Compound/PW C000675 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Stearoylcarnitine
stoichiometric coefficient: 1.0

(2E)-Tetradecenoyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: (2E)-Tetradecenoyl-CoA

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Compound/PW C000940 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

SubPathwayInteraction416
type: Interaction
name: SubPathwayReaction
name: SubPathway416Reaction
participant: Lauroyl-CoA

Reference/PubChem-compound 6083
type: UnificationXref
id: 6083
db: PubChem-compound

Palmitoyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Palmitoyl-CoA

ChemicalStructure/PW C002009
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

ChemicalStructure/PW C002010
type: ChemicalStructure
structure format: SMILES

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Carnitine O-palmitoyltransferase 2, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Carnitine O-palmitoyltransferase 2, mitochondrial

Reference/UniProt P55084
type: UnificationXref
id: P55084
db: UniProt

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

SubPathwayInteraction400
type: Interaction
name: SubPathway400Reaction
name: SubPathwayReaction
participant: Acetyl-CoA

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Acetyl-CoA
name: SubPathwayInput

Trifunctional enzyme subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrial Inner Membrane
entity reference: Trifunctional enzyme subunit alpha, mitochondrial

Compound/PW C002796 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Octadecenoyl-CoA
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001171
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 65113
type: UnificationXref
id: 65113
db: PubChem-compound

3-Hydroxytetradecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Hydroxytetradecanoyl-CoA

Compound/PW C002010 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Tetradecenoyl-CoA
stoichiometric coefficient: 1.0

TransportCatalysis99
type: Catalysis
controller: Mitochondrial carnitine/acylcarnitine carrier protein
controlled: Transport128
control type: ACTIVATION

ReactionCatalysis1324
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: Reaction1588
control type: ACTIVATION

ReactionCatalysis1323
type: Catalysis
controller: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
controlled: 1.1.1.35
control type: ACTIVATION

3-oxotetradecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-oxotetradecanoyl-CoA

ReactionCatalysis1328
type: Catalysis
controller: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
controlled: 1.1.1.35
control type: ACTIVATION

ReactionCatalysis1327
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: 4.2.1.17
control type: ACTIVATION

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Coenzyme A

Reference/ChemSpider 10140190
type: UnificationXref
id: 10140190
db: ChemSpider

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Reference/KEGG Compound C16216
type: UnificationXref
id: C16216
db: KEGG Compound

Palmitoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Palmitoyl-CoA

Reference/KEGG Compound C16218
type: UnificationXref
id: C16218
db: KEGG Compound

Adenosine monophosphate
type: SmallMoleculeReference
xref: Reference/CAS 61-19-8
xref: Reference/ChemSpider 5858
xref: Reference/HMDB HMDB0000045
xref: Reference/BioCyc AMP
xref: Reference/ChEBI CHEBI 16027
xref: Reference/PubChem-compound 6083
xref: Reference/KEGG Compound C00020
chemical formula: C10H14N5O7P
molecular weight: 347.06308
structure: ChemicalStructure/PW C000032

ReactionCatalysis1320
type: Catalysis
controller: Enoyl-CoA hydratase, mitochondrial
controlled: 4.2.1.17
control type: ACTIVATION

ReactionCatalysis1322
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: 1.1.1.35
control type: ACTIVATION

ReactionCatalysis1321
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: 4.2.1.17
control type: ACTIVATION

Reference/UniProt P40939
type: UnificationXref
id: P40939
db: UniProt

4.2.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002009 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001996 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001996 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002009 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: (2E)-Hexadecenoyl-CoA
right: Water
spontaneous: false
EC number: 4.2.1.17
left: 3-Hydroxyhexadecanoyl-CoA
name: 3-Hydroxyhexadecanoyl-CoA ↔ (2E)-Hexadecenoyl-CoA + Water
conversion direction: REVERSIBLE

2.3.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002740 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001171 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001171 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002740 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: 3-oxohexadecanoyl-CoA
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.16
left: Acetyl-CoA
left: Tetradecanoyl-CoA
name: Acetyl-CoA + Tetradecanoyl-CoA ↔ 3-oxohexadecanoyl-CoA + Coenzyme A
conversion direction: REVERSIBLE

1.1.1.35
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002740 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001996 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
right: 3-oxohexadecanoyl-CoA
right: NADH
right: Hydrogen Ion
spontaneous: false
EC number: 1.1.1.35
left: 3-Hydroxyhexadecanoyl-CoA
left: NAD
name: 3-Hydroxyhexadecanoyl-CoA + NAD ↔ 3-oxohexadecanoyl-CoA + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Carnitine O-palmitoyltransferase 1, liver isoform
type: Protein
cellular location: Mitochondrial Outer Membrane
entity reference: Carnitine O-palmitoyltransferase 1, liver isoform

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/HMDB HMDB0003934
type: UnificationXref
id: HMDB0003934
db: HMDB

Reference/HMDB HMDB0003935
type: UnificationXref
id: HMDB0003935
db: HMDB

Reference/HMDB HMDB0003932
type: UnificationXref
id: HMDB0003932
db: HMDB

4.2.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001998 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001998 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002010 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002010 Mitochondrial Matrix/Stoichiometry/1.0
right: Water
right: (2E)-Tetradecenoyl-CoA
spontaneous: false
EC number: 4.2.1.17
left: 3-Hydroxytetradecanoyl-CoA
name: 3-Hydroxytetradecanoyl-CoA ↔ (2E)-Tetradecenoyl-CoA + Water
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

3-Hydroxyhexadecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: 3-Hydroxyhexadecanoyl-CoA

2.3.1.16
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001999 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001928 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001999 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001928 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: 3-oxotetradecanoyl-CoA
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.16
left: Lauroyl-CoA
left: Acetyl-CoA
name: Acetyl-CoA + Lauroyl-CoA → 3-oxotetradecanoyl-CoA + Coenzyme A
conversion direction: LEFT_TO_RIGHT

L-Carnitine
type: SmallMoleculeReference
xref: Reference/BioCyc CARNITINE
xref: Reference/ChEBI CHEBI 16347
xref: Reference/PubChem-compound 10917
xref: Reference/CAS 541-15-1
xref: Reference/KEGG Compound C00318
xref: Reference/HMDB HMDB0000062
xref: Reference/ChemSpider 10455
chemical formula: C7H15NO3
molecular weight: 161.1052
structure: ChemicalStructure/PW C000044

1.1.1.35
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001999 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001998 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001998 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001999 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: 3-oxotetradecanoyl-CoA
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.1.1.35
left: NAD
left: 3-Hydroxytetradecanoyl-CoA
name: 3-Hydroxytetradecanoyl-CoA + NAD ↔ 3-oxotetradecanoyl-CoA + Hydrogen Ion + NADH
conversion direction: REVERSIBLE

ReactionCatalysis1331
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: 2.3.1.16
control type: ACTIVATION

ReactionCatalysis1330
type: Catalysis
controller: 3-ketoacyl-CoA thiolase, mitochondrial
controlled: 2.3.1.16
control type: ACTIVATION

NADH
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: NADH

Reference/BioCyc PALMITYL-COA
type: UnificationXref
id: PALMITYL-COA
db: BioCyc

ReactionCatalysis1333
type: Catalysis
controller: 3-ketoacyl-CoA thiolase, mitochondrial
controlled: Reaction1588
control type: ACTIVATION

3-oxohexadecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: 3-oxohexadecanoyl-CoA

Compound/PW C001171 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetradecanoyl-CoA
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001999
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis292
type: Catalysis
controller: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: 1.3.8.8
control type: ACTIVATION

ChemicalStructure/PW C001998
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

ChemicalStructure/PW C001996
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 440602
type: UnificationXref
id: 440602
db: PubChem-compound

Reference/PubChem-compound 440601
type: UnificationXref
id: 440601
db: PubChem-compound

Reference/PubChem-compound 440600
type: UnificationXref
id: 440600
db: PubChem-compound

ReactionCatalysis1346
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: 2.3.1.16
control type: ACTIVATION

ReactionCatalysis1345
type: Catalysis
controller: 3-ketoacyl-CoA thiolase, mitochondrial
controlled: 2.3.1.16
control type: ACTIVATION

Fatty Acid Elongation in Mitochondria
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway399
pathway component: SubPathwayInteraction399
xref: Reference/PathWhiz PW000022
xref: Reference/SMPDB SMP0000054
name: SubPathway

Reference/HMDB HMDB0001521
type: UnificationXref
id: HMDB0001521
db: HMDB

ChemicalStructure/PW C000675
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C

Reference/HMDB HMDB0003945
type: UnificationXref
id: HMDB0003945
db: HMDB

Reference/HMDB HMDB0003946
type: UnificationXref
id: HMDB0003946
db: HMDB

(2E)-Octadecenoyl-CoA
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0006529
xref: Reference/PubChem-compound 53477850
xref: Reference/KEGG Compound C16218
chemical formula: C39H68N7O17P3S
molecular weight: 1031.3605
structure: ChemicalStructure/PW C002796

Compound/PW C000871 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Stearoyl-CoA
stoichiometric coefficient: 1.0

Reduced electron-transfer flavoprotein
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Reduced electron-transfer flavoprotein

1.3.8.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001031 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic69 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic70 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002009 Mitochondrion/Stoichiometry/1.0
right: Reduced electron-transfer flavoprotein
right: (2E)-Hexadecenoyl-CoA
spontaneous: false
EC number: 1.3.8.8
left: electron-transfer flavoprotein
left: Palmitoyl-CoA
name: Palmitoyl-CoA + electron-transfer flavoprotein → (2E)-Hexadecenoyl-CoA + Reduced electron-transfer flavoprotein
conversion direction: LEFT_TO_RIGHT

Reaction774
type: BiochemicalReaction
participant stoichiometry: Compound/Generic69 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic70 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002010 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001171 Mitochondrion/Stoichiometry/1.0
right: Reduced electron-transfer flavoprotein
right: (2E)-Tetradecenoyl-CoA
spontaneous: false
left: Tetradecanoyl-CoA
left: electron-transfer flavoprotein
name: Tetradecanoyl-CoA + electron-transfer flavoprotein → (2E)-Tetradecenoyl-CoA + Reduced electron-transfer flavoprotein
conversion direction: LEFT_TO_RIGHT

Stearoylcarnitine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Stearoylcarnitine

Compound/PW C008527 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: (S)-Hydroxyoctadecanoyl-CoA
stoichiometric coefficient: 1.0

ReactionCatalysis1344
type: Catalysis
controller: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
controlled: 1.1.1.35
control type: ACTIVATION

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

ReactionCatalysis1343
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: 4.2.1.17
control type: ACTIVATION

Citric Acid Cycle
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway400
pathway component: SubPathwayInteraction400
xref: Reference/PathWhiz PW000005
xref: Reference/SMPDB SMP0000057
name: SubPathway

Compound/PW C001144 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

ReactionCatalysis285
type: Catalysis
controller: Enoyl-CoA hydratase, mitochondrial
controlled: 4.2.1.17
control type: ACTIVATION

ReactionCatalysis284
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: 1.1.1.35
control type: ACTIVATION

ReactionCatalysis281
type: Catalysis
controller: Enoyl-CoA hydratase, mitochondrial
controlled: 4.2.1.17
control type: ACTIVATION

ReactionCatalysis280
type: Catalysis
controller: Trifunctional enzyme, mitochondrial
controlled: 1.1.1.35
control type: ACTIVATION

ChemicalStructure/PW C002740
type: ChemicalStructure
structure format: SMILES

Compound/PW C000675 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Stearoylcarnitine
stoichiometric coefficient: 1.0

Compound/PW C000170 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

NAD
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: NAD

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Coenzyme A

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

Compound/PW C000661 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Stearic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 61526
type: UnificationXref
id: CHEBI:61526
db: ChEBI

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

TransportCatalysis100
type: Catalysis
controller: Mitochondrial carnitine/acylcarnitine carrier protein
controlled: Transport129
control type: ACTIVATION

Reference/PubChem-compound 52922056
type: UnificationXref
id: 52922056
db: PubChem-compound

Reference/ChEBI CHEBI 15521
type: UnificationXref
id: CHEBI:15521
db: ChEBI

electron-transfer flavoprotein
type: SmallMolecule
cellular location: Mitochondrion
entity reference: electron-transfer flavoprotein

Reference/CAS 541-15-1
type: UnificationXref
id: 541-15-1
db: CAS

Reference/ChEBI CHEBI 15525
type: UnificationXref
id: CHEBI:15525
db: ChEBI

(2E)-Hexadecenoyl-CoA
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003945
xref: Reference/ChEBI CHEBI 61526
xref: Reference/KEGG Compound C05272
xref: Reference/PubChem-compound 46173176
xref: Reference/ChemSpider 26332261
xref: Reference/CAS 4460-95-1
chemical formula: C37H64N7O17P3S
molecular weight: 1003.3292
structure: ChemicalStructure/PW C002009

Reference/HMDB HMDB0013640
type: UnificationXref
id: HMDB0013640
db: HMDB

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

ChemicalStructure/PW C002796
type: ChemicalStructure
structure format: SMILES

(2E)-Tetradecenoyl-CoA
type: SmallMoleculeReference
xref: Reference/ChemSpider 4444333
xref: Reference/ChEBI CHEBI 27721
xref: Reference/HMDB HMDB0003946
xref: Reference/CAS 38795-33-4
xref: Reference/KEGG Compound C05273
xref: Reference/PubChem-compound 5280767
chemical formula: C35H60N7O17P3S
molecular weight: 975.2979
structure: ChemicalStructure/PW C002010

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Reference/ChEBI CHEBI 28842
type: UnificationXref
id: CHEBI:28842
db: ChEBI

(2E)-Tetradecenoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: (2E)-Tetradecenoyl-CoA

Reference/ChemSpider 5091
type: UnificationXref
id: 5091
db: ChemSpider

Reference/ChEBI CHEBI 28726
type: UnificationXref
id: CHEBI:28726
db: ChEBI

Compound/PW C000871 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Stearoyl-CoA
stoichiometric coefficient: 1.0

Protein/46 Mitochondrial Inner Membrane/Stoichiometry/4.0
type: Stoichiometry
physical entity: Trifunctional enzyme subunit beta, mitochondrial
stoichiometric coefficient: 4.0

Pyrophosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Pyrophosphate

Reference/UniProt P30084
type: UnificationXref
id: P30084
db: UniProt

Compound/PW C000721 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15532
type: UnificationXref
id: CHEBI:15532
db: ChEBI

Compound/PW C000044 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

(2E)-Hexadecenoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: (2E)-Hexadecenoyl-CoA

Compound/PW C002009 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Hexadecenoyl-CoA
stoichiometric coefficient: 1.0

Reference/CAS 1763-10-6
type: UnificationXref
id: 1763-10-6
db: CAS

Reference/BioCyc TETRADECANOYL-COA
type: UnificationXref
id: TETRADECANOYL-COA
db: BioCyc

(2E)-Hexadecenoyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: (2E)-Hexadecenoyl-CoA

Reference/KEGG Compound C05259
type: UnificationXref
id: C05259
db: KEGG Compound

Reference/KEGG Compound C05258
type: UnificationXref
id: C05258
db: KEGG Compound

Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids
type: Pathway
pathway order: PathwaySubPathway/399
pathway order: PathwaySubPathway/398
pathway order: PathwaySubPathway/416
pathway order: PathwayEnzymeReaction/1841
pathway order: PathwayEnzymeReaction/1846
pathway order: PathwayTransport/1799
pathway order: PathwayEnzymeReaction/1801
pathway order: PathwayEnzymeReaction/1845
pathway order: PathwayEnzymeReaction/211607
pathway order: PathwayEnzymeReaction/1844
pathway order: PathwayEnzymeReaction/1843
pathway order: PathwayEnzymeReaction/1806
pathway order: PathwayEnzymeReaction/1805
pathway order: PathwayEnzymeReaction/1804
pathway order: PathwayEnzymeReaction/1803
pathway order: PathwayEnzymeReaction/1808
pathway order: PathwaySubPathway/400
pathway order: PathwayEnzymeReaction/3384
pathway order: PathwayEnzymeReaction/3385
pathway order: PathwayEnzymeReaction/1798
pathway order: PathwayEnzymeReaction/1797
pathway order: PathwayTransport/1800
pathway order: PathwayEnzymeReaction/1813
pathway order: PathwayEnzymeReaction/1812
pathway order: PathwayEnzymeReaction/1811
pathway order: PathwayEnzymeReaction/1817
pathway order: PathwayEnzymeReaction/1839
pathway order: PathwayEnzymeReaction/1838
pathway order: PathwayEnzymeReaction/1815
pathway order: PathwayEnzymeReaction/1818
pathway component: ReactionCatalysis292
pathway component: TransportCatalysis99
pathway component: ReactionCatalysis1324
pathway component: ReactionCatalysis1346
pathway component: ReactionCatalysis1323
pathway component: ReactionCatalysis1345
pathway component: Fatty Acid Elongation in Mitochondria
pathway component: ReactionCatalysis1328
pathway component: ReactionCatalysis1327
pathway component: 1.3.8.8
pathway component: Reaction774
pathway component: ReactionCatalysis1320
pathway component: Fatty Acid Biosynthesis
pathway component: ReactionCatalysis1322
pathway component: ReactionCatalysis1344
pathway component: ReactionCatalysis1321
pathway component: ReactionCatalysis1343
pathway component: Citric Acid Cycle
pathway component: 4.2.1.17
pathway component: ReactionCatalysis285
pathway component: 2.3.1.16
pathway component: 1.1.1.35
pathway component: ReactionCatalysis284
pathway component: ReactionCatalysis281
pathway component: ReactionCatalysis280
pathway component: 2.3.1.21
pathway component: 6.2.1.3
pathway component: ReactionCatalysis1317
pathway component: Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids
pathway component: ReactionCatalysis1316
pathway component: ReactionCatalysis1319
pathway component: ReactionCatalysis1318
pathway component: Transport129
pathway component: Transport128
pathway component: ReactionCatalysis1331
pathway component: Reaction1588
pathway component: ReactionCatalysis1330
pathway component: ReactionCatalysis1333
pathway component: TransportCatalysis100
xref: Reference/PathWhiz PW000173
xref: Reference/SMPDB SMP0000482
organism: Homo sapiens

Reference/UniProt P23786
type: UnificationXref
id: P23786
db: UniProt

Reference/KEGG Compound C05260
type: UnificationXref
id: C05260
db: KEGG Compound

Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway416
pathway component: SubPathwayInteraction416
xref: Reference/SMPDB SMP0000481
xref: Reference/PathWhiz PW000172
name: SubPathway

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Protein/381 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Trifunctional enzyme subunit alpha, mitochondrial
stoichiometric coefficient: 4.0

Reference/KEGG Compound C05261
type: UnificationXref
id: C05261
db: KEGG Compound

Reference/SMPDB SMP0000057
type: UnificationXref
id: SMP0000057
db: SMPDB

Reference/SMPDB SMP0000054
type: UnificationXref
id: SMP0000054
db: SMPDB

Tetradecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 3130-72-1
xref: Reference/HMDB HMDB0001521
xref: Reference/KEGG Compound C02593
xref: Reference/ChEBI CHEBI 15532
xref: Reference/ChemSpider 58623
xref: Reference/PubChem-compound 65113
xref: Reference/BioCyc TETRADECANOYL-COA
chemical formula: C35H62N7O17P3S
molecular weight: 977.3136
structure: ChemicalStructure/PW C001171

Compound/PW C001420 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/PW C001996 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxyhexadecanoyl-CoA
stoichiometric coefficient: 1.0

Mitochondrial carnitine/acylcarnitine carrier protein
type: ProteinReference
xref: Reference/UniProt O43772

Compound/PW C001171 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetradecanoyl-CoA
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen Ion

Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

ChemicalStructure/PW C002775
type: ChemicalStructure
structure format: SMILES

(S)-Hydroxyoctadecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: (S)-Hydroxyoctadecanoyl-CoA

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/KEGG Compound C05273
type: UnificationXref
id: C05273
db: KEGG Compound

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

Reference/KEGG Compound C05272
type: UnificationXref
id: C05272
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005743
type: UnificationXref
id: GO:0005743
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

Compound/PW C002740 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-oxohexadecanoyl-CoA
stoichiometric coefficient: 1.0

3-Hydroxyhexadecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: 3-Hydroxyhexadecanoyl-CoA

Compound/PW C001999 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-oxotetradecanoyl-CoA
stoichiometric coefficient: 1.0

Reference/CAS 34619-89-1
type: UnificationXref
id: 34619-89-1
db: CAS

Compound/PW C001998 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxytetradecanoyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C001996 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxyhexadecanoyl-CoA
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: Water

Palmitoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Palmitoyl-CoA

(2E)-Hexadecenoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: (2E)-Hexadecenoyl-CoA

Palmitoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 15667
xref: Reference/ChemSpider 14902
xref: Reference/HMDB HMDB0001338
xref: Reference/ChEBI CHEBI 15525
xref: Reference/KEGG Compound C00154
xref: Reference/CAS 1763-10-6
xref: Reference/BioCyc PALMITYL-COA
chemical formula: C37H66N7O17P3S
molecular weight: 1005.34485
structure: ChemicalStructure/PW C001031

Reference/ChEBI CHEBI 27721
type: UnificationXref
id: CHEBI:27721
db: ChEBI

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

ReactionCatalysis1317
type: Catalysis
controller: Long-chain-fatty-acid--CoA ligase 1
controlled: 6.2.1.3
control type: ACTIVATION

ReactionCatalysis1316
type: Catalysis
controller: Carnitine O-palmitoyltransferase 1
controlled: 2.3.1.21
control type: ACTIVATION

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

ReactionCatalysis1319
type: Catalysis
controller: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
controlled: 1.3.8.8
control type: ACTIVATION

ReactionCatalysis1318
type: Catalysis
controller: Carnitine O-palmitoyltransferase 2, mitochondrial
controlled: 2.3.1.21
control type: ACTIVATION

Reference/HMDB HMDB0001338
type: UnificationXref
id: HMDB0001338
db: HMDB

Reference/UniProt P33121
type: UnificationXref
id: P33121
db: UniProt

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

Reference/ChemSpider 58623
type: UnificationXref
id: 58623
db: ChemSpider

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

electron-transfer flavoprotein
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 5086

Compound/PW C001031 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitoyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reduced electron-transfer flavoprotein
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 5086

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Compound/PW C000871 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Stearoyl-CoA
stoichiometric coefficient: 1.0

Protein/31 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: 3-ketoacyl-CoA thiolase, mitochondrial
stoichiometric coefficient: 4.0

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Reference/BioCyc STEAROYL-COA
type: UnificationXref
id: STEAROYL-COA
db: BioCyc

Reference/PubChem-compound 5280767
type: UnificationXref
id: 5280767
db: PubChem-compound

Reference/SMPDB SMP0000481
type: UnificationXref
id: SMP0000481
db: SMPDB

Reference/SMPDB SMP0000482
type: UnificationXref
id: SMP0000482
db: SMPDB

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Stearoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Stearoyl-CoA

Compound/PW C000675 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Stearoylcarnitine
stoichiometric coefficient: 1.0

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Compound/PW C002796 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Octadecenoyl-CoA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 10917
type: UnificationXref
id: 10917
db: PubChem-compound

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Compound/PW C000044 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

Compound/PW C001031 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitoyl-CoA
stoichiometric coefficient: 1.0

Protein/99 Mitochondrion/Stoichiometry/4.0
type: Stoichiometry
physical entity: Long-chain specific acyl-CoA dehydrogenase, mitochondrial
stoichiometric coefficient: 4.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/ChemSpider 10455
type: UnificationXref
id: 10455
db: ChemSpider

Compound/PW C000414 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q16836
type: UnificationXref
id: Q16836
db: UniProt

Trifunctional enzyme subunit beta, mitochondrial
type: ProteinReference
xref: Reference/UniProt P55084
organism: Homo sapiens

Reference/ChEBI CHEBI 15541
type: UnificationXref
id: CHEBI:15541
db: ChEBI

Reference/ChemSpider 14902
type: UnificationXref
id: 14902
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Compound/PW C008527 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: (S)-Hydroxyoctadecanoyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Reference/HMDB HMDB0000827
type: UnificationXref
id: HMDB0000827
db: HMDB

Protein/373 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0006498
type: UnificationXref
id: HMDB0006498
db: HMDB

Fatty Acid Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway398
pathway component: SubPathwayInteraction398
xref: Reference/PathWhiz PW000167
xref: Reference/SMPDB SMP0000456
name: SubPathway

ChemicalStructure/PW C001928
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C01832
type: UnificationXref
id: C01832
db: KEGG Compound

Reference/CAS 122364-86-7
type: UnificationXref
id: 122364-86-7
db: CAS

Reference/ChEBI CHEBI 27402
type: UnificationXref
id: CHEBI:27402
db: ChEBI

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/373 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

Reference/PathWhiz PW000022
type: UnificationXref
id: PW000022
db: PathWhiz

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

3-ketoacyl-CoA thiolase, mitochondrial
type: Complex
component stoichiometry: Protein/31 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: 3-ketoacyl-CoA thiolase, mitochondrial

Reference/HMDB HMDB0000848
type: UnificationXref
id: HMDB0000848
db: HMDB

Compound/PW C001999 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-oxotetradecanoyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 145018
type: UnificationXref
id: 145018
db: ChemSpider

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Compound/PW C002775 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-oxooctadecanoyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C001998 Mitochondrial Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Hydroxytetradecanoyl-CoA
stoichiometric coefficient: 1.0

Reference/ChemSpider 17216373
type: UnificationXref
id: 17216373
db: ChemSpider

Trifunctional enzyme subunit alpha, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Trifunctional enzyme subunit alpha, mitochondrial

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 16347
type: UnificationXref
id: CHEBI:16347
db: ChEBI

3-ketoacyl-CoA thiolase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: 3-ketoacyl-CoA thiolase, mitochondrial

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

Reference/SMPDB SMP0000456
type: UnificationXref
id: SMP0000456
db: SMPDB

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 15491
type: UnificationXref
id: CHEBI:15491
db: ChEBI

Reference/ChemSpider 389499
type: UnificationXref
id: 389499
db: ChemSpider

Reference/ChemSpider 389498
type: UnificationXref
id: 389498
db: ChemSpider

Reference/ChEBI CHEBI 27466
type: UnificationXref
id: CHEBI:27466
db: ChEBI

(S)-Hydroxyoctadecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 53481913
xref: Reference/HMDB HMDB0013640
chemical formula: C40H71N6O18P3S
molecular weight: 1048.3759
structure: ChemicalStructure/PW C008527

ChemicalStructure/PW C000661
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCCCC(O)=O

Reference/CAS 86370-20-9
type: UnificationXref
id: 86370-20-9
db: CAS

Reference/ChemSpider 26332261
type: UnificationXref
id: 26332261
db: ChemSpider

Reference/PubChem-compound 439229
type: UnificationXref
id: 439229
db: PubChem-compound

Reference/ChEBI CHEBI 84644
type: UnificationXref
id: CHEBI:84644
db: ChEBI

Reference/ChemSpider 4444333
type: UnificationXref
id: 4444333
db: ChemSpider

Reference/CAS 362-66-3
type: UnificationXref
id: 362-66-3
db: CAS

Compound/PW C002740 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-oxohexadecanoyl-CoA
stoichiometric coefficient: 1.0

(2E)-Tetradecenoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: (2E)-Tetradecenoyl-CoA

Reference/PathWhiz PW000005
type: UnificationXref
id: PW000005
db: PathWhiz

Protein/46 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Trifunctional enzyme subunit beta, mitochondrial
stoichiometric coefficient: 4.0

L-Carnitine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Carnitine

Long-chain specific acyl-CoA dehydrogenase, mitochondrial
type: Complex
component stoichiometry: Protein/99 Mitochondrion/Stoichiometry/4.0
cellular location: Mitochondrion
component: Long-chain specific acyl-CoA dehydrogenase, mitochondrial

Reference/PubChem-compound 46173176
type: UnificationXref
id: 46173176
db: PubChem-compound

Compound/PW C002010 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: (2E)-Tetradecenoyl-CoA
stoichiometric coefficient: 1.0

Reference/CAS 6244-92-4
type: UnificationXref
id: 6244-92-4
db: CAS

Reference/KEGG Compound C00412
type: UnificationXref
id: C00412
db: KEGG Compound

ChemicalStructure/PW C000871
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 15667
type: UnificationXref
id: 15667
db: PubChem-compound

Long-chain specific acyl-CoA dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P28330
organism: Homo sapiens

Compound/PW C001099 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

2.3.1.21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000675 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000675 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000871 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000871 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Stearoylcarnitine
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.21
left: L-Carnitine
left: Stearoyl-CoA
name: L-Carnitine + Stearoyl-CoA ↔ Coenzyme A + Stearoylcarnitine
conversion direction: REVERSIBLE

Compound/PW C000044 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

6.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000661 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000871 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000032 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Stearoyl-CoA
right: Adenosine monophosphate
right: Pyrophosphate
spontaneous: false
EC number: 6.2.1.3
left: Coenzyme A
left: Adenosine triphosphate
left: Stearic acid
name: Adenosine triphosphate + Coenzyme A + Stearic acid → Adenosine monophosphate + Pyrophosphate + Stearoyl-CoA
conversion direction: LEFT_TO_RIGHT

3-oxotetradecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: 3-oxotetradecanoyl-CoA

(S)-Hydroxyoctadecanoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Inner Membrane
entity reference: (S)-Hydroxyoctadecanoyl-CoA

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

1.1.1.35
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002775 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008527 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002775 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008527 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Mitochondrial Inner Membrane/Stoichiometry/1.0
right: 3-oxooctadecanoyl-CoA
right: Hydrogen Ion
right: NADH
spontaneous: false
EC number: 1.1.1.35
left: NAD
left: (S)-Hydroxyoctadecanoyl-CoA
name: (S)-Hydroxyoctadecanoyl-CoA + NAD → 3-oxooctadecanoyl-CoA + Hydrogen Ion + NADH
conversion direction: LEFT_TO_RIGHT

Reaction1588
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002775 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002775 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031 Mitochondrial Matrix/Stoichiometry/1.0
right: Acetyl-CoA
right: Palmitoyl-CoA
spontaneous: false
left: 3-oxooctadecanoyl-CoA
left: Coenzyme A
name: 3-oxooctadecanoyl-CoA + Coenzyme A → Acetyl-CoA + Palmitoyl-CoA
conversion direction: LEFT_TO_RIGHT

1.3.8.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C002796 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic69 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/Generic70 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000871 Mitochondrion/Stoichiometry/1.0
right: (2E)-Octadecenoyl-CoA
right: Reduced electron-transfer flavoprotein
spontaneous: false
EC number: 1.3.8.8
left: electron-transfer flavoprotein
left: Stearoyl-CoA
name: Stearoyl-CoA + electron-transfer flavoprotein → (2E)-Octadecenoyl-CoA + Reduced electron-transfer flavoprotein
conversion direction: LEFT_TO_RIGHT

4.2.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008527 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002796 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002796 Mitochondrial Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C008527 Mitochondrial Matrix/Stoichiometry/1.0
right: (S)-Hydroxyoctadecanoyl-CoA
spontaneous: false
EC number: 4.2.1.17
left: Water
left: (2E)-Octadecenoyl-CoA
name: (2E)-Octadecenoyl-CoA + Water → (S)-Hydroxyoctadecanoyl-CoA
conversion direction: LEFT_TO_RIGHT