Glutathione synthetase
type: Protein
cellular location: Cytoplasm
entity reference: Glutathione synthetase

Reference/HMDB HMDB0061365
type: UnificationXref
id: HMDB0061365
db: HMDB

Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/HMDB HMDB0061366
type: UnificationXref
id: HMDB0061366
db: HMDB

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

ChemicalStructure/PW C000448
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CS)C(O)=O

Compound/PW C040690 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: S-(methyl)glutathione
stoichiometric coefficient: 1.0

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Protein/491 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate--cysteine ligase catalytic subunit
stoichiometric coefficient: 1.0

Reference/BioCyc CYS
type: UnificationXref
id: CYS
db: BioCyc

Reference/ChemSpider 32980411
type: UnificationXref
id: 32980411
db: ChemSpider

Reference/ChemSpider 388596
type: UnificationXref
id: 388596
db: ChemSpider

(5-L-Glutamyl)-L-amino acid
type: SmallMolecule
cellular location: Cell Membrane
entity reference: (5-L-Glutamyl)-L-amino acid

γ-Glutamylcysteine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00669
xref: Reference/PubChem-compound 123938
xref: Reference/HMDB HMDB0001049
xref: Reference/ChemSpider 110467
xref: Reference/ChEBI CHEBI 17515
xref: Reference/CAS 636-58-8
xref: Reference/BioCyc L-GAMMA-GLUTAMYLCYSTEINE
chemical formula: C8H14N2O5S
molecular weight: 250.06235
structure: ChemicalStructure/PW C000826

Methyl-S-cystein
type: SmallMolecule
cellular location: Cytosol
entity reference: Methyl-S-cystein

Glutathione
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Glutathione

Protein/800 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: 5-oxoprolinase
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

Reference/ChemSpider 255
type: UnificationXref
id: 255
db: ChemSpider

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Protein/2599 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Gamma-glutamyltransferase 6
stoichiometric coefficient: 2.0

Pyroglutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyroglutamic acid

Glutathione reductase, mitochondrial
type: Complex
component stoichiometry: Protein/191 Mitochondrial Matrix/Stoichiometry/2.0
cellular location: Mitochondrial Matrix
component: Glutathione reductase, mitochondrial

ReactionCatalysis28
type: Catalysis
controller: Glutathione peroxidase 1
controlled: 1.11.1.9
control type: ACTIVATION

Reference/ChEBI CHEBI 50619
type: UnificationXref
id: CHEBI:50619
db: ChEBI

Compound/PW C000055 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cysteinylglycine
stoichiometric coefficient: 1.0

Glutathione reductase, mitochondrial
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Glutathione reductase, mitochondrial

ReactionCatalysis26
type: Catalysis
controller: Glutathione reductase, mitochondrial
controlled: 1.8.1.7
control type: ACTIVATION

Caspase-7
type: ProteinReference
xref: Reference/UniProt P55210
organism: Homo sapiens

Reference/HMDB HMDB0061370
type: UnificationXref
id: HMDB0061370
db: HMDB

Reference/KEGG Compound C01419
type: UnificationXref
id: C01419
db: KEGG Compound

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Reference/PubChem-compound 1004
type: UnificationXref
id: 1004
db: PubChem-compound

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Compound/PW C000080 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 1.0

Cysteinylglycine
type: SmallMolecule
cellular location: Cytosol
entity reference: Cysteinylglycine

Caspase-7
type: Protein
cellular location: Cytosol
entity reference: Caspase-7

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Protein/2599 Cell Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Gamma-glutamyltransferase 6
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0061369
type: UnificationXref
id: HMDB0061369
db: HMDB

Reference/HMDB HMDB0061367
type: UnificationXref
id: HMDB0061367
db: HMDB

Reference/HMDB HMDB0061368
type: UnificationXref
id: HMDB0061368
db: HMDB

Compound/PW C001847 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxidized glutathione
stoichiometric coefficient: 1.0

Reference/UniProt P07203
type: UnificationXref
id: P07203
db: UniProt

Glycine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glycine

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Gamma-glutamyltransferase 6
type: Protein
cellular location: Cytosol
entity reference: Gamma-glutamyltransferase 6

Reference/ChemSpider 7127
type: UnificationXref
id: 7127
db: ChemSpider

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/ChEBI CHEBI 17561
type: UnificationXref
id: CHEBI:17561
db: ChEBI

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

Reference/UniProt P48637
type: UnificationXref
id: P48637
db: UniProt

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/KEGG Compound C11347
type: UnificationXref
id: C11347
db: KEGG Compound

Reference/ChemSpider 950
type: UnificationXref
id: 950
db: ChemSpider

TransportCatalysis5386
type: Catalysis
controller: Mitochondrial 2-oxoglutarate/malate carrier protein
controlled: Transport14569
control type: ACTIVATION

Reference/KEGG Compound C13645
type: UnificationXref
id: C13645
db: KEGG Compound

Glutathione peroxidase 1
type: Complex
component stoichiometry: Protein/773 Mitochondrial Matrix/Stoichiometry/4.0
cellular location: Mitochondrial Matrix
component: Glutathione peroxidase 1

Glutathione S-transferase omega-2
type: Complex
component stoichiometry: Protein/776 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Glutathione S-transferase omega-2

Protein/435 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Aminopeptidase N
stoichiometric coefficient: 2.0

Reference/PathWhiz PW000038
type: UnificationXref
id: PW000038
db: PathWhiz

Reference/ChemSpider 5735
type: UnificationXref
id: 5735
db: ChemSpider

Glutathione synthetase
type: ProteinReference
xref: Reference/UniProt P48637
organism: Homo sapiens

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Reference/PubChem-compound 5862
type: UnificationXref
id: 5862
db: PubChem-compound

Hydrogen bromide
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen bromide

Compound/PW C000078 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

6.3.2.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000826 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphoric acid
right: γ-Glutamylcysteine
spontaneous: false
EC number: 6.3.2.2
left: L-Cysteine
left: Adenosine triphosphate
left: L-Glutamic acid
name: Adenosine triphosphate + L-Cysteine + L-Glutamic acid → Adenosine diphosphate + Phosphoric acid + γ-Glutamylcysteine
conversion direction: LEFT_TO_RIGHT

6.3.2.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000826 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphoric acid
right: Glutathione
spontaneous: false
EC number: 6.3.2.3
left: Glycine
left: Adenosine triphosphate
left: γ-Glutamylcysteine
name: Adenosine triphosphate + Glycine + γ-Glutamylcysteine → Adenosine diphosphate + Glutathione + Phosphoric acid
conversion direction: LEFT_TO_RIGHT

5-oxoprolinase
type: Protein
cellular location: Cytosol
entity reference: 5-oxoprolinase

3.5.2.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001441 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000182 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Phosphoric acid
right: L-Glutamic acid
spontaneous: false
EC number: 3.5.2.9
left: Adenosine triphosphate
left: Pyroglutamic acid
left: Water
name: Adenosine triphosphate + Pyroglutamic acid + 2 Water → Adenosine diphosphate + L-Glutamic acid + Phosphoric acid
conversion direction: LEFT_TO_RIGHT

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

5-Oxoprolinase Deficiency
type: Pathway
pathway order: PathwayEnzymeReaction/3342
pathway order: PathwayEnzymeReaction/3343
pathway order: PathwayEnzymeReaction/3344
pathway order: PathwayEnzymeReaction/3345
pathway order: PathwaySubPathway/799
pathway order: PathwaySubPathway/800
pathway order: PathwayEnzymeReaction/3340
pathway order: PathwayEnzymeReaction/3341
pathway order: PathwaySubPathway/798
pathway order: PathwayEnzymeReaction/3339
pathway order: PathwayTransport/2511922
pathway order: PathwayEnzymeReaction/3335
pathway order: PathwayEnzymeReaction/3336
pathway order: PathwayEnzymeReaction/3337
pathway order: PathwayEnzymeReaction/3338
pathway order: PathwayEnzymeReaction/61
pathway order: PathwayEnzymeReaction/2511923
pathway order: PathwayEnzymeReaction/2511925
pathway component: ReactionCatalysis58
pathway component: ReactionCatalysis56
pathway component: ReactionCatalysis57
pathway component: ReactionCatalysis54
pathway component: ReactionCatalysis55
pathway component: Transport14569
pathway component: ReactionCatalysis2138
pathway component: ReactionCatalysis2137
pathway component: ReactionCatalysis2139
pathway component: Glutamate Metabolism
pathway component: TransportCatalysis5386
pathway component: 3.4.11.2
pathway component: ReactionCatalysis2136
pathway component: Reaction2268
pathway component: Cysteine Metabolism
pathway component: 1.8.1.7
pathway component: ReactionCatalysis28
pathway component: ReactionCatalysis26
pathway component: 1.11.1.9
pathway component: Taurine and Hypotaurine Metabolism
pathway component: 2.3.2.4
pathway component: Reaction2270
pathway component: ReactionCatalysis2141
pathway component: ReactionCatalysis2140
pathway component: 6.3.2.2
pathway component: 6.3.2.3
pathway component: Reaction587
pathway component: 3.5.2.9
pathway component: ReactionCatalysis2142
xref: Reference/SMPDB SMP0000500
xref: Reference/PathWhiz PW000476
organism: Homo sapiens

Reference/BioCyc GLY
type: UnificationXref
id: GLY
db: BioCyc

ReactionCatalysis58
type: Catalysis
controller: Glutathione S-transferase omega-2
controlled: Reaction587
control type: ACTIVATION

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Gamma-glutamylcyclotransferase
type: Complex
component stoichiometry: Protein/4542 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Gamma-glutamylcyclotransferase

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16856
type: UnificationXref
id: CHEBI:16856
db: ChEBI

Reference/ChEBI CHEBI 16977
type: UnificationXref
id: CHEBI:16977
db: ChEBI

Reference/PubChem-compound 124886
type: UnificationXref
id: 124886
db: PubChem-compound

L-Glutamic acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Glutamic acid
name: SubPathwayOutput

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/UniProt Q02978
type: UnificationXref
id: Q02978
db: UniProt

ReactionCatalysis56
type: Catalysis
controller: Glutathione synthetase
controlled: 6.3.2.3
control type: ACTIVATION

ReactionCatalysis57
type: Catalysis
controller: Aminopeptidase N
controlled: 3.4.11.2
control type: ACTIVATION

Reference/KEGG Compound C03740
type: UnificationXref
id: C03740
db: KEGG Compound

ReactionCatalysis54
type: Catalysis
controller: 5-oxoprolinase
controlled: 3.5.2.9
control type: ACTIVATION

ReactionCatalysis55
type: Catalysis
controller: Glutamate--cysteine ligase
controlled: 6.3.2.2
control type: ACTIVATION

Reference/HMDB HMDB0000574
type: UnificationXref
id: HMDB0000574
db: HMDB

Compound/PW C000080 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 2.0

Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Reference/CAS 7664-38-2
type: UnificationXref
id: 7664-38-2
db: CAS

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Compound/PW C040694 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-amino acid
stoichiometric coefficient: 1.0

Glycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000123
xref: Reference/BioCyc GLY
xref: Reference/ChemSpider 730
xref: Reference/PubChem-compound 5257127
xref: Reference/CAS 56-40-6
xref: Reference/ChEBI CHEBI 15428
xref: Reference/KEGG Compound C00037
chemical formula: C2H5NO2
molecular weight: 75.03203
structure: ChemicalStructure/PW C000078

Compound/PW C040691 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methyl-S-Cysteinylglycine
stoichiometric coefficient: 1.0

3.4.11.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040692 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040691 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Cytosol/Stoichiometry/1.0
right: Methyl-S-cystein
right: Glycine
spontaneous: false
EC number: 3.4.11.2
left: Methyl-S-Cysteinylglycine
left: Water
name: Methyl-S-Cysteinylglycine + Water → Glycine + Methyl-S-cystein
conversion direction: LEFT_TO_RIGHT

Reaction2268
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040690 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040691 Cytosol/Stoichiometry/1.0
right: Methyl-S-Cysteinylglycine
right: L-Glutamic acid
spontaneous: false
left: S-(methyl)glutathione
left: Water
name: S-(methyl)glutathione + Water → L-Glutamic acid + Methyl-S-Cysteinylglycine
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Glutathione
type: SmallMolecule
cellular location: Cytosol
entity reference: Glutathione

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Compound/PW C040693 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: (5-L-Glutamyl)-L-amino acid
stoichiometric coefficient: 1.0

Reference/BioCyc CPD-589
type: UnificationXref
id: CPD-589
db: BioCyc

Reference/KEGG Compound C00127
type: UnificationXref
id: C00127
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Protein/776 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glutathione S-transferase omega-2
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Compound/PW C000055 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cysteinylglycine
stoichiometric coefficient: 1.0

Protein/773 Mitochondrial Matrix/Stoichiometry/4.0
type: Stoichiometry
physical entity: Glutathione peroxidase 1
stoichiometric coefficient: 4.0

Reference/CAS 56-41-7
type: UnificationXref
id: 56-41-7
db: CAS

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Oxidized glutathione
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003337
xref: Reference/PubChem-compound 5255796
xref: Reference/ChemSpider 950
xref: Reference/KEGG Compound C00127
xref: Reference/BioCyc OXIDIZED-GLUTATHIONE
xref: Reference/CAS 27025-41-8
xref: Reference/ChEBI CHEBI 17858
chemical formula: C20H32N6O12S2
molecular weight: 612.152
structure: ChemicalStructure/PW C001847

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Mitochondrial 2-oxoglutarate/malate carrier protein
type: Protein
entity reference: Mitochondrial 2-oxoglutarate/malate carrier protein

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P48506
type: UnificationXref
id: P48506
db: UniProt

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/UniProt P48507
type: UnificationXref
id: P48507
db: UniProt

Reference/PubChem-compound 5257127
type: UnificationXref
id: 5257127
db: PubChem-compound

Glutathione
type: SmallMoleculeReference
xref: Reference/CAS 70-18-8
xref: Reference/HMDB HMDB0000125
xref: Reference/BioCyc OXIDIZED-GLUTATHIONE
xref: Reference/KEGG Compound C00051
xref: Reference/ChEBI CHEBI 16856
xref: Reference/PubChem-compound 124886
xref: Reference/ChemSpider 111188
chemical formula: C10H17N3O6S
molecular weight: 307.0838
structure: ChemicalStructure/PW C000080

Reference/PubChem-compound 55290163
type: UnificationXref
id: 55290163
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

γ-Glutamylcysteine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: γ-Glutamylcysteine

Compound/PW C040689 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen bromide
stoichiometric coefficient: 1.0

Compound/PW C000146 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/KEGG Compound C18447
type: UnificationXref
id: C18447
db: KEGG Compound

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

Reference/ChEBI CHEBI 39275
type: UnificationXref
id: CHEBI:39275
db: ChEBI

ChemicalStructure/PW C040689
type: ChemicalStructure
structure format: SMILES
structure data: Br

Reference/SMPDB SMP0000500
type: UnificationXref
id: SMP0000500
db: SMPDB

Gamma-glutamylcyclotransferase
type: Protein
cellular location: Cytosol
entity reference: Gamma-glutamylcyclotransferase

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Compound/PW C040694 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-amino acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5950
type: UnificationXref
id: 5950
db: PubChem-compound

5-oxoprolinase
type: ProteinReference
xref: Reference/UniProt O14841
organism: Homo sapiens

ChemicalStructure/PW C001441
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/ChemSpider 6083
type: UnificationXref
id: 6083
db: ChemSpider

Reference/UniProt P15144
type: UnificationXref
id: P15144
db: UniProt

Compound/PW C000080 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0031524
type: UnificationXref
id: HMDB0031524
db: HMDB

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Cysteinylglycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000078
xref: Reference/PubChem-compound 439498
xref: Reference/CAS 19246-18-5
xref: Reference/KEGG Compound C01419
xref: Reference/ChEBI CHEBI 4047
xref: Reference/ChemSpider 388596
xref: Reference/BioCyc CYS-GLY
chemical formula: C5H10N2O3S
molecular weight: 178.04121
structure: ChemicalStructure/PW C000055

Reference/CAS 10035-10-6
type: UnificationXref
id: 10035-10-6
db: CAS

ChemicalStructure/PW C040693
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(O)=O

ChemicalStructure/PW C040692
type: ChemicalStructure
structure format: SMILES
structure data: CSC(N)C(O)=O

Bromomethane
type: SmallMoleculeReference
xref: Reference/ChemSpider 6083
xref: Reference/ChEBI CHEBI 39275
xref: Reference/HMDB HMDB0031524
xref: Reference/CAS 74-83-9
xref: Reference/KEGG Compound C18447
xref: Reference/PubChem-compound 6323
chemical formula: CH3Br
molecular weight: 93.94181
structure: ChemicalStructure/PW C012706

ChemicalStructure/PW C040691
type: ChemicalStructure
structure format: SMILES
structure data: CS[C@@H](N)CNCC(O)=O

Compound/PW C000826 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Glutamylcysteine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040690
type: ChemicalStructure
structure format: SMILES

Cysteine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway799
pathway component: SubPathwayInteraction799
xref: Reference/SMPDB SMP0000013
xref: Reference/PathWhiz PW000018
name: SubPathway

Compound/PW C000080 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040694
type: ChemicalStructure
structure format: SMILES
structure data: C[C@H](N)C(O)=O

SubPathwayInteraction800
type: Interaction
name: SubPathway800Reaction
name: SubPathwayReaction
participant: L-Cysteine

Gamma-glutamyltransferase 6
type: ProteinReference
xref: Reference/UniProt Q6P531
organism: Homo sapiens

Compound/PW C040692 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Methyl-S-cystein
stoichiometric coefficient: 1.0

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/ChemSpider 5653
type: UnificationXref
id: 5653
db: ChemSpider

L-Glutamic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Glutamic acid

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/HMDB HMDB0000123
type: UnificationXref
id: HMDB0000123
db: HMDB

Reference/ChEBI CHEBI 26078
type: UnificationXref
id: CHEBI:26078
db: ChEBI

Pyroglutamic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C01879
xref: Reference/BioCyc CPD-589
xref: Reference/HMDB HMDB0000267
xref: Reference/ChEBI CHEBI 18183
xref: Reference/ChemSpider 7127
xref: Reference/CAS 98-79-3
xref: Reference/PubChem-compound 7405
chemical formula: C5H7NO3
molecular weight: 129.04259
structure: ChemicalStructure/PW C000182

Reference/SMPDB SMP0000072
type: UnificationXref
id: SMP0000072
db: SMPDB

Reference/HMDB HMDB0000125
type: UnificationXref
id: HMDB0000125
db: HMDB

Aminopeptidase N
type: Complex
component stoichiometry: Protein/435 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Aminopeptidase N

Taurine and Hypotaurine Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway800
pathway component: SubPathwayInteraction800
xref: Reference/PathWhiz PW000038
xref: Reference/SMPDB SMP0000021
name: SubPathway

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

2.3.2.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000182 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000826 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytosol/Stoichiometry/1.0
right: L-Cysteine
right: Pyroglutamic acid
spontaneous: false
EC number: 2.3.2.4
left: γ-Glutamylcysteine
name: γ-Glutamylcysteine → L-Cysteine + Pyroglutamic acid
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Glutamate--cysteine ligase regulatory subunit
type: ProteinReference
xref: Reference/UniProt P48507
organism: Homo sapiens

Reaction2270
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040693 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000055 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040694 Cell Membrane/Stoichiometry/1.0
right: Cysteinylglycine
right: (5-L-Glutamyl)-L-amino acid
spontaneous: false
left: Glutathione
left: L-amino acid
name: Glutathione + L-amino acid → (5-L-Glutamyl)-L-amino acid + Cysteinylglycine
conversion direction: LEFT_TO_RIGHT

2.3.2.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040694 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000182 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040693 Cytosol/Stoichiometry/1.0
right: L-amino acid
right: Pyroglutamic acid
spontaneous: false
EC number: 2.3.2.4
left: (5-L-Glutamyl)-L-amino acid
name: (5-L-Glutamyl)-L-amino acid → L-amino acid + Pyroglutamic acid
conversion direction: LEFT_TO_RIGHT

Glutamate--cysteine ligase catalytic subunit
type: ProteinReference
xref: Reference/UniProt P48506
organism: Homo sapiens

Compound/PW C000182 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyroglutamic acid
stoichiometric coefficient: 1.0

Compound/PW C040693 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: (5-L-Glutamyl)-L-amino acid
stoichiometric coefficient: 1.0

Reference/CAS 70-18-8
type: UnificationXref
id: 70-18-8
db: CAS

Reference/BioCyc OXIDIZED-GLUTATHIONE
type: UnificationXref
id: OXIDIZED-GLUTATHIONE
db: BioCyc

SubPathwayInteraction798
type: Interaction
name: SubPathway798Reaction
name: SubPathwayReaction
participant: L-Glutamic acid

Hydrogen bromide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061365
xref: Reference/ChemSpider 255
xref: Reference/PubChem-compound 22169024
xref: Reference/CAS 10035-10-6
xref: Reference/KEGG Compound C13645
xref: Reference/ChEBI CHEBI 47266
chemical formula: BrH
molecular weight: 79.92616
structure: ChemicalStructure/PW C040689

SubPathwayInteraction799
type: Interaction
name: SubPathwayReaction
name: SubPathway799Reaction
participant: L-Cysteine

Reference/CAS 52-90-4
type: UnificationXref
id: 52-90-4
db: CAS

Gamma-glutamylcyclotransferase
type: ProteinReference
xref: Reference/UniProt O75223
organism: Homo sapiens

Reference/CAS 98-79-3
type: UnificationXref
id: 98-79-3
db: CAS

Protein/4542 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Gamma-glutamylcyclotransferase
stoichiometric coefficient: 2.0

Reference/UniProt O75223
type: UnificationXref
id: O75223
db: UniProt

Reference/KEGG Compound C00037
type: UnificationXref
id: C00037
db: KEGG Compound

ReactionCatalysis2138
type: Catalysis
controller: Caspase-7
controlled: 3.4.11.2
control type: ACTIVATION

ChemicalStructure/PW C000055
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CS)C(=O)NCC(O)=O

Compound/PW C000826 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-Glutamylcysteine
stoichiometric coefficient: 1.0

ReactionCatalysis2137
type: Catalysis
controller: Aminopeptidase N
controlled: 3.4.11.2
control type: ACTIVATION

Reference/PubChem-compound 5255796
type: UnificationXref
id: 5255796
db: PubChem-compound

ReactionCatalysis2139
type: Catalysis
controller: Gamma-glutamyltransferase 6
controlled: Reaction2270
control type: ACTIVATION

Reference/KEGG Compound C00041
type: UnificationXref
id: C00041
db: KEGG Compound

Reference/ChemSpider 110467
type: UnificationXref
id: 110467
db: ChemSpider

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

ChemicalStructure/PW C012706
type: ChemicalStructure
structure format: SMILES
structure data: CBr

S-(methyl)glutathione
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061366
xref: Reference/KEGG Compound C11347
xref: Reference/ChemSpider 103128
xref: Reference/CAS 2922-56-7
xref: Reference/PubChem-compound 115260
chemical formula: C11H19N3O6S
molecular weight: 321.09946
structure: ChemicalStructure/PW C040690

Protein/191 Mitochondrial Matrix/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glutathione reductase, mitochondrial
stoichiometric coefficient: 2.0

ReactionCatalysis2136
type: Catalysis
controller: Gamma-glutamyltransferase 6
controlled: Reaction2268
control type: ACTIVATION

Methyl-S-Cysteinylglycine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061367
chemical formula: C5H12N2O2S
molecular weight: 164.06195
structure: ChemicalStructure/PW C040691

Compound/PW C000448 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Cysteine
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Methyl-S-cystein
type: SmallMoleculeReference
xref: Reference/PubChem-compound 55290163
xref: Reference/ChemSpider 32980411
xref: Reference/HMDB HMDB0061368
chemical formula: C3H7NO2S
molecular weight: 121.01975
structure: ChemicalStructure/PW C040692

(5-L-Glutamyl)-L-amino acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 440103
xref: Reference/ChEBI CHEBI 50619
xref: Reference/ChemSpider 389104
xref: Reference/HMDB HMDB0061369
xref: Reference/CAS 5875-41-2
xref: Reference/KEGG Compound C03740
chemical formula: C8H14N2O5
molecular weight: 218.09027
structure: ChemicalStructure/PW C040693

L-amino acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00041
xref: Reference/HMDB HMDB0061370
xref: Reference/ChemSpider 5735
xref: Reference/ChEBI CHEBI 16977
xref: Reference/CAS 56-41-7
xref: Reference/PubChem-compound 5950
chemical formula: C3H7NO2
molecular weight: 89.047676
structure: ChemicalStructure/PW C040694

Reference/ChemSpider 103128
type: UnificationXref
id: 103128
db: ChemSpider

Glutamate--cysteine ligase catalytic subunit
type: Protein
cellular location: Cytosol
entity reference: Glutamate--cysteine ligase catalytic subunit

Reference/ChEBI CHEBI 17515
type: UnificationXref
id: CHEBI:17515
db: ChEBI

Cysteinylglycine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Cysteinylglycine

Compound/PW C000143 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Aminopeptidase N
type: ProteinReference
xref: Reference/UniProt P15144
organism: Homo sapiens

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

Reference/HMDB HMDB0000267
type: UnificationXref
id: HMDB0000267
db: HMDB

Mitochondrial 2-oxoglutarate/malate carrier protein
type: ProteinReference
xref: Reference/UniProt Q02978

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Reference/KEGG Compound C00051
type: UnificationXref
id: C00051
db: KEGG Compound

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

ReactionCatalysis2141
type: Catalysis
controller: Caspase-7
controlled: 3.4.11.2
control type: ACTIVATION

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

ReactionCatalysis2140
type: Catalysis
controller: Gamma-glutamylcyclotransferase
controlled: 2.3.2.4
control type: ACTIVATION

Compound/PW C001420 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 2.0

ReactionCatalysis2142
type: Catalysis
controller: Gamma-glutamylcyclotransferase
controlled: 2.3.2.4
control type: ACTIVATION

Reference/SMPDB SMP0000013
type: UnificationXref
id: SMP0000013
db: SMPDB

ChemicalStructure/PW C000182
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)[C@@H]1CCC(=O)N1

Gamma-glutamyltransferase 6
type: Protein
cellular location: Cell Membrane
entity reference: Gamma-glutamyltransferase 6

Glutathione S-transferase omega-2
type: Protein
cellular location: Cytosol
entity reference: Glutathione S-transferase omega-2

5-oxoprolinase
type: Complex
component stoichiometry: Protein/800 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: 5-oxoprolinase

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/CAS 2922-56-7
type: UnificationXref
id: 2922-56-7
db: CAS

ChemicalStructure/PW C000826
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(=O)N[C@@H](CS)C(O)=O)C(O)=O

Compound/PW C001441 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/BioCyc CYS-GLY
type: UnificationXref
id: CYS-GLY
db: BioCyc

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6323
type: UnificationXref
id: 6323
db: PubChem-compound

Gamma-glutamyltransferase 6
type: Complex
component stoichiometry: Protein/2599 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Gamma-glutamyltransferase 6

Reference/PubChem-compound 123938
type: UnificationXref
id: 123938
db: PubChem-compound

Hydrogen peroxide
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Hydrogen peroxide

Reference/CAS 19246-18-5
type: UnificationXref
id: 19246-18-5
db: CAS

(5-L-Glutamyl)-L-amino acid
type: SmallMolecule
cellular location: Cytosol
entity reference: (5-L-Glutamyl)-L-amino acid

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Reference/PubChem-compound 115260
type: UnificationXref
id: 115260
db: PubChem-compound

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

Reference/SMPDB SMP0000021
type: UnificationXref
id: SMP0000021
db: SMPDB

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

1.8.1.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001847 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080 Mitochondrial Matrix/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000143 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Mitochondrial Matrix/Stoichiometry/1.0
right: NADP
right: Glutathione
spontaneous: false
EC number: 1.8.1.7
left: NADPH
left: Oxidized glutathione
name: NADPH + Oxidized glutathione ↔ 2 Glutathione + NADP
conversion direction: REVERSIBLE

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Phosphoric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoric acid

Reference/ChEBI CHEBI 17858
type: UnificationXref
id: CHEBI:17858
db: ChEBI

1.11.1.9
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001847 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080 Mitochondrial Matrix/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001420 Mitochondrial Matrix/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001783 Mitochondrial Matrix/Stoichiometry/1.0
right: Water
right: Oxidized glutathione
spontaneous: false
EC number: 1.11.1.9
left: Hydrogen peroxide
left: Glutathione
name: 2 Glutathione + Hydrogen peroxide → Oxidized glutathione + 2 Water
conversion direction: LEFT_TO_RIGHT

Compound/PW C000095 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Reference/CAS 56-40-6
type: UnificationXref
id: 56-40-6
db: CAS

Reference/PubChem-compound 7405
type: UnificationXref
id: 7405
db: PubChem-compound

Phosphoric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphoric acid

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Compound/PW C012706 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Bromomethane
stoichiometric coefficient: 1.0

γ-Glutamylcysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: γ-Glutamylcysteine

Reference/UniProt O14841
type: UnificationXref
id: O14841
db: UniProt

Protein/736 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glutathione synthetase
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 15428
type: UnificationXref
id: CHEBI:15428
db: ChEBI

Reference/UniProt Q9H4Y5
type: UnificationXref
id: Q9H4Y5
db: UniProt

S-(methyl)glutathione
type: SmallMolecule
cellular location: Cytosol
entity reference: S-(methyl)glutathione

Aminopeptidase N
type: Protein
cellular location: Cytosol
entity reference: Aminopeptidase N

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

3.4.11.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000055 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000078 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000448 Cytosol/Stoichiometry/1.0
right: L-Cysteine
right: Glycine
spontaneous: false
EC number: 3.4.11.2
left: Cysteinylglycine
left: Water
name: Cysteinylglycine + Water → Glycine + L-Cysteine
conversion direction: LEFT_TO_RIGHT

Glutamate--cysteine ligase
type: Complex
component stoichiometry: Protein/491 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/492 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Glutamate--cysteine ligase regulatory subunit
component: Glutamate--cysteine ligase catalytic subunit

Reference/UniProt P55210
type: UnificationXref
id: P55210
db: UniProt

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/UniProt P00390
type: UnificationXref
id: P00390
db: UniProt

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Glutathione
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Glutathione

Reference/CAS 74-83-9
type: UnificationXref
id: 74-83-9
db: CAS

Reference/CAS 636-58-8
type: UnificationXref
id: 636-58-8
db: CAS

Reference/ChemSpider 979
type: UnificationXref
id: 979
db: ChemSpider

Compound/PW C001783 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Transport14569
type: Transport
participant stoichiometry: Compound/PW C000080 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000080 Cytoplasm/Stoichiometry/1.0
right: Glutathione
spontaneous: false
left: Glutathione
name: Glutathione (↔) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 440103
type: UnificationXref
id: 440103
db: PubChem-compound

Reference/ChemSpider 730
type: UnificationXref
id: 730
db: ChemSpider

NADP
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADP

Water
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Water

Phosphoric acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/ChEBI CHEBI 26078
xref: Reference/CAS 7664-38-2
xref: Reference/PubChem-compound 1004
xref: Reference/ChemSpider 979
xref: Reference/HMDB HMDB0002142
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001441

Glutamate Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway798
pathway component: SubPathwayInteraction798
xref: Reference/SMPDB SMP0000072
xref: Reference/PathWhiz PW000003
name: SubPathway

L-amino acid
type: SmallMolecule
cellular location: Cytosol
entity reference: L-amino acid

Reference/PathWhiz PW000018
type: UnificationXref
id: PW000018
db: PathWhiz

Glutathione
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glutathione

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Gamma-glutamyltransferase 6
type: Complex
component stoichiometry: Protein/2599 Cell Membrane/Stoichiometry/2.0
cellular location: Cell Membrane
component: Gamma-glutamyltransferase 6

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

L-Cysteine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Cysteine
name: SubPathwayInput

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

L-amino acid
type: SmallMolecule
cellular location: Cell Membrane
entity reference: L-amino acid

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Compound/PW C000078 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycine
stoichiometric coefficient: 1.0

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003337
type: UnificationXref
id: HMDB0003337
db: HMDB

Methyl-S-Cysteinylglycine
type: SmallMolecule
cellular location: Cytosol
entity reference: Methyl-S-Cysteinylglycine

Reference/ChEBI CHEBI 4047
type: UnificationXref
id: CHEBI:4047
db: ChEBI

Glutathione reductase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P00390
organism: Homo sapiens

Protein/492 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutamate--cysteine ligase regulatory subunit
stoichiometric coefficient: 1.0

Oxidized glutathione
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: Oxidized glutathione

Reference/ChemSpider 111188
type: UnificationXref
id: 111188
db: ChemSpider

Glutathione synthetase
type: Complex
component stoichiometry: Protein/736 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Glutathione synthetase

Bromomethane
type: SmallMolecule
cellular location: Cytosol
entity reference: Bromomethane

NADPH
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: NADPH

Reference/ChemSpider 389104
type: UnificationXref
id: 389104
db: ChemSpider

L-Cysteine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000574
xref: Reference/CAS 52-90-4
xref: Reference/KEGG Compound C00097
xref: Reference/BioCyc CYS
xref: Reference/ChemSpider 5653
xref: Reference/PubChem-compound 5862
xref: Reference/ChEBI CHEBI 17561
chemical formula: C3H7NO2S
molecular weight: 121.01975
structure: ChemicalStructure/PW C000448

Reference/CAS 27025-41-8
type: UnificationXref
id: 27025-41-8
db: CAS

Reference/PathWhiz PW000003
type: UnificationXref
id: PW000003
db: PathWhiz

Reference/KEGG Compound C00097
type: UnificationXref
id: C00097
db: KEGG Compound

Reference/CAS 5875-41-2
type: UnificationXref
id: 5875-41-2
db: CAS

Glycine
type: SmallMolecule
cellular location: Cytosol
entity reference: Glycine

Reference/HMDB HMDB0000078
type: UnificationXref
id: HMDB0000078
db: HMDB

Reference/PubChem-compound 439498
type: UnificationXref
id: 439498
db: PubChem-compound

Compound/PW C001441 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoric acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Reference/HMDB HMDB0001049
type: UnificationXref
id: HMDB0001049
db: HMDB

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

ChemicalStructure/PW C000078
type: ChemicalStructure
structure format: SMILES
structure data: NCC(O)=O

Reference/PubChem-compound 22169024
type: UnificationXref
id: 22169024
db: PubChem-compound

Reference/ChEBI CHEBI 47266
type: UnificationXref
id: CHEBI:47266
db: ChEBI

Reference/KEGG Compound C00669
type: UnificationXref
id: C00669
db: KEGG Compound

Reference/KEGG Compound C01879
type: UnificationXref
id: C01879
db: KEGG Compound

Glutamate--cysteine ligase regulatory subunit
type: Protein
cellular location: Cytosol
entity reference: Glutamate--cysteine ligase regulatory subunit

Glutathione peroxidase 1
type: Protein
cellular location: Mitochondrial Matrix
entity reference: Glutathione peroxidase 1

Reference/PathWhiz PW000476
type: UnificationXref
id: PW000476
db: PathWhiz

Glutathione S-transferase omega-2
type: ProteinReference
xref: Reference/UniProt Q9H4Y5
organism: Homo sapiens

Reference/BioCyc L-GAMMA-GLUTAMYLCYSTEINE
type: UnificationXref
id: L-GAMMA-GLUTAMYLCYSTEINE
db: BioCyc

ChemicalStructure/PW C001847
type: ChemicalStructure
structure format: SMILES

Glutathione peroxidase 1
type: ProteinReference
xref: Reference/UniProt P07203
organism: Homo sapiens

Reference/ChEBI CHEBI 18183
type: UnificationXref
id: CHEBI:18183
db: ChEBI

Reference/UniProt Q6P531
type: UnificationXref
id: Q6P531
db: UniProt

Compound/PW C000080 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glutathione
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000080
type: ChemicalStructure
structure format: SMILES

Reaction587
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000080 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040690 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040689 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C012706 Cytosol/Stoichiometry/1.0
right: S-(methyl)glutathione
right: Hydrogen bromide
spontaneous: false
left: Glutathione
left: Bromomethane
name: Bromomethane + Glutathione → Hydrogen bromide + S-(methyl)glutathione
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0002142
type: UnificationXref
id: HMDB0002142
db: HMDB