Transport110
type: Transport
participant stoichiometry: Compound/PW C002751 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002751 Peroxisome/Stoichiometry/1.0
right: Hexacosanoyl-CoA
spontaneous: false
left: Hexacosanoyl-CoA
name: Hexacosanoyl-CoA (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Peroxisome
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 10724
type: UnificationXref
id: 10724
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/PubChem-compound 3082227
type: UnificationXref
id: 3082227
db: PubChem-compound

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/PubChem-compound 65113
type: UnificationXref
id: 65113
db: PubChem-compound

Reference/KEGG Compound C00318
type: UnificationXref
id: C00318
db: KEGG Compound

Peroxisomal membrane protein 11C
type: Protein
entity reference: Peroxisomal membrane protein 11C

Dodecanoic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Dodecanoic acid

ChemicalStructure/PW C002751
type: ChemicalStructure
structure format: SMILES

Transport114
type: Transport
participant stoichiometry: Compound/PW C000497 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000497 Peroxisome/Stoichiometry/1.0
right: Dodecanoic acid
spontaneous: false
left: Dodecanoic acid
name: Dodecanoic acid (→) Transport: Homo sapiens, Cell, Peroxisome to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Transport115
type: Transport
participant stoichiometry: Compound/PW C000497 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000497 Mitochondrion/Stoichiometry/1.0
right: Dodecanoic acid
spontaneous: false
left: Dodecanoic acid
name: Dodecanoic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrion
conversion direction: LEFT_TO_RIGHT

Lauroyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc LAUROYLCOA-CPD
xref: Reference/KEGG Compound C01832
xref: Reference/ChEBI CHEBI 15521
xref: Reference/HMDB HMDB0003571
xref: Reference/CAS 6244-92-4
xref: Reference/ChemSpider 145018
xref: Reference/PubChem-compound 165436
chemical formula: C33H58N7O17P3S
molecular weight: 949.2823
structure: ChemicalStructure/PW C001928

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Acetyl-CoA
type: SmallMolecule
cellular location: Peroxisome
entity reference: Acetyl-CoA

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

L-Acetylcarnitine
type: SmallMolecule
cellular location: Cytosol
entity reference: L-Acetylcarnitine

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

2.3.1.21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000497 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001928 Mitochondrion/Stoichiometry/1.0
right: Lauroyl-CoA
right: L-Carnitine
spontaneous: false
EC number: 2.3.1.21
left: Coenzyme A
left: Dodecanoic acid
name: Coenzyme A + Dodecanoic acid → L-Carnitine + Lauroyl-CoA
conversion direction: LEFT_TO_RIGHT

Mitochondrial carnitine/acylcarnitine carrier protein
type: Protein
entity reference: Mitochondrial carnitine/acylcarnitine carrier protein

Reference/HMDB HMDB0006526
type: UnificationXref
id: HMDB0006526
db: HMDB

Tetracosanoyl-CoA
type: SmallMolecule
cellular location: Peroxisome
entity reference: Tetracosanoyl-CoA
name: SubPathwayInput

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

L-Carnitine
type: SmallMoleculeReference
xref: Reference/BioCyc CARNITINE
xref: Reference/ChEBI CHEBI 16347
xref: Reference/PubChem-compound 10917
xref: Reference/CAS 541-15-1
xref: Reference/KEGG Compound C00318
xref: Reference/HMDB HMDB0000062
xref: Reference/ChemSpider 10455
chemical formula: C7H15NO3
molecular weight: 161.1052
structure: ChemicalStructure/PW C000044

Compound/PW C001928 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lauroyl-CoA
stoichiometric coefficient: 1.0

Protein/5713/Stoichiometry/1.0
type: Stoichiometry
physical entity: Peroxisomal membrane protein PEX14
stoichiometric coefficient: 1.0

L-Acetylcarnitine
type: SmallMoleculeReference
xref: Reference/CAS 3040-38-8
xref: Reference/PubChem-compound 1
xref: Reference/ChemSpider 21243783
xref: Reference/HMDB HMDB0000201
xref: Reference/KEGG Compound C02571
xref: Reference/BioCyc (-)o-acetylcarnitine
xref: Reference/ChEBI CHEBI 73024
chemical formula: C9H17NO4
molecular weight: 203.11575
structure: ChemicalStructure/PW C000129

Lauroyl-CoA
type: SmallMolecule
entity reference: Lauroyl-CoA
name: SubPathwayOutput

Dodecanoic acid
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Dodecanoic acid

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 25202335
type: UnificationXref
id: 25202335
db: PubChem-compound

Acetyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Acetyl-CoA

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Tetracosanoic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 10724
xref: Reference/HMDB HMDB0002003
xref: Reference/PubChem-compound 11197
xref: Reference/KEGG Compound C08320
xref: Reference/ChEBI CHEBI 28866
xref: Reference/BioCyc TETRACOSANOATE
xref: Reference/CAS 557-59-5
chemical formula: C24H48O2
molecular weight: 368.36542
structure: ChemicalStructure/PW C001340

Lauroyl-CoA
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Lauroyl-CoA
name: SubPathwayInput

Reference/HMDB HMDB0001521
type: UnificationXref
id: HMDB0001521
db: HMDB

Tetracosanoyl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 24305-30-4
xref: Reference/ChEBI CHEBI 52974
xref: Reference/PubChem-compound 3082227
xref: Reference/HMDB HMDB0006526
xref: Reference/KEGG Compound C16529
chemical formula: C45H82N7O17P3S
molecular weight: 1117.4701
structure: ChemicalStructure/PW C002794

Dodecanoic acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 3756
xref: Reference/KEGG Compound C02679
xref: Reference/CAS 143-07-7
xref: Reference/ChEBI CHEBI 30805
xref: Reference/HMDB HMDB0000638
xref: Reference/PubChem-compound 3893
chemical formula: C12H24O2
molecular weight: 200.17763
structure: ChemicalStructure/PW C000497

Compound/PW C000129 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Acetylcarnitine
stoichiometric coefficient: 1.0

Beta oxidation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway309
pathway component: SubPathwayInteraction309
name: SubPathway

hexacosanoic acid
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002356
xref: Reference/ChEBI CHEBI 31009
xref: Reference/CAS 506-46-7
xref: Reference/PubChem-compound 10469
xref: Reference/BioCyc 2-PG
xref: Reference/ChemSpider 10037
chemical formula: C26H52O2
molecular weight: 396.39673
structure: ChemicalStructure/PW C001589

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA
name: SubPathwayOutput

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Reference/CAS 3040-38-8
type: UnificationXref
id: 3040-38-8
db: CAS

Reference/UniProt Q9UKG9
type: UnificationXref
id: Q9UKG9
db: UniProt

Reference/HMDB HMDB0000201
type: UnificationXref
id: HMDB0000201
db: HMDB

L-Acetylcarnitine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Acetylcarnitine

Carnitine O-acetyltransferase
type: Protein
cellular location: Mitochondrion
entity reference: Carnitine O-acetyltransferase

Compound/PW C002794 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetracosanoyl-CoA
stoichiometric coefficient: 1.0

Mitochondrion
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005739

Reference/ChemSpider 28184701
type: UnificationXref
id: 28184701
db: ChemSpider

Reference/ChemSpider 10037
type: UnificationXref
id: 10037
db: ChemSpider

Reference/ChEBI CHEBI 15521
type: UnificationXref
id: CHEBI:15521
db: ChEBI

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ATP-binding cassette sub-family D member 1
type: ProteinReference
xref: Reference/UniProt P33897

ATP-binding cassette sub-family D member 2
type: ProteinReference
xref: Reference/UniProt Q9UBJ2

Peroxisomal membrane protein PEX13
type: ProteinReference
xref: Reference/UniProt Q92968

Reference/CAS 541-15-1
type: UnificationXref
id: 541-15-1
db: CAS

Peroxisomal membrane protein PEX14
type: ProteinReference
xref: Reference/UniProt O75381

ChemicalStructure/PW C000129
type: ChemicalStructure
structure format: SMILES
structure data: CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C001099 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/CAS 506-46-7
type: UnificationXref
id: 506-46-7
db: CAS

Carnitine O-acetyltransferase
type: ProteinReference
xref: Reference/UniProt P43155
organism: Homo sapiens

Reference/BioCyc LAUROYLCOA-CPD
type: UnificationXref
id: LAUROYLCOA-CPD
db: BioCyc

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001340
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCCCCCCCCCC(O)=O

ChemicalStructure/PW C000497
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCC(O)=O

ChemicalStructure/PW C002794
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Compound/PW C000129 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Acetylcarnitine
stoichiometric coefficient: 1.0

Reference/UniProt Q92968
type: UnificationXref
id: Q92968
db: UniProt

Carnitine O-palmitoyltransferase 2, mitochondrial
type: Protein
cellular location: Mitochondrion
entity reference: Carnitine O-palmitoyltransferase 2, mitochondrial

Reference/ChEBI CHEBI 15532
type: UnificationXref
id: CHEBI:15532
db: ChEBI

Peroxisomal membrane protein 11C
type: ProteinReference
xref: Reference/UniProt Q96HA9

ChemicalStructure/PW C001589
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCCCCCCCCCCCC(O)=O

Protein/5714/Stoichiometry/1.0
type: Stoichiometry
physical entity: ATP-binding cassette sub-family D member 1
stoichiometric coefficient: 1.0

Lauroyl-CoA
type: SmallMolecule
cellular location: Peroxisome
entity reference: Lauroyl-CoA

Compound/PW C002794 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetracosanoyl-CoA
stoichiometric coefficient: 1.0

Reference/BioCyc TETRADECANOYL-COA
type: UnificationXref
id: TETRADECANOYL-COA
db: BioCyc

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Compound/PW C001928 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lauroyl-CoA
stoichiometric coefficient: 1.0

Reference/UniProt P23786
type: UnificationXref
id: P23786
db: UniProt

Reference/GENE ONTOLOGY GO 0005759
type: UnificationXref
id: GO:0005759
db: GENE ONTOLOGY

Tetradecanoyl-CoA
type: SmallMolecule
entity reference: Tetradecanoyl-CoA
name: SubPathwayOutput

Tetradecanoyl-CoA
type: SmallMoleculeReference
xref: Reference/CAS 3130-72-1
xref: Reference/HMDB HMDB0001521
xref: Reference/KEGG Compound C02593
xref: Reference/ChEBI CHEBI 15532
xref: Reference/ChemSpider 58623
xref: Reference/PubChem-compound 65113
xref: Reference/BioCyc TETRADECANOYL-COA
chemical formula: C35H62N7O17P3S
molecular weight: 977.3136
structure: ChemicalStructure/PW C001171

Reference/CAS 3130-72-1
type: UnificationXref
id: 3130-72-1
db: CAS

Coenzyme A
type: SmallMolecule
cellular location: Cytosol
entity reference: Coenzyme A

Reference/KEGG Compound C02679
type: UnificationXref
id: C02679
db: KEGG Compound

Compound/PW C000940 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Mitochondrial carnitine/acylcarnitine carrier protein
type: ProteinReference
xref: Reference/UniProt O43772

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/ChEBI CHEBI 73024
type: UnificationXref
id: CHEBI:73024
db: ChEBI

Compound/PW C001589 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: hexacosanoic acid
stoichiometric coefficient: 1.0

Reference/PubChem-compound 3893
type: UnificationXref
id: 3893
db: PubChem-compound

Reference/PubChem-compound 1
type: UnificationXref
id: 1
db: PubChem-compound

Reference/HMDB HMDB0006459
type: UnificationXref
id: HMDB0006459
db: HMDB

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

L-Carnitine
type: SmallMolecule
cellular location: Mitochondrion
entity reference: L-Carnitine

Reference/SMPDB SMP0000517
type: UnificationXref
id: SMP0000517
db: SMPDB

Reference/BioCyc CARNITINE
type: UnificationXref
id: CARNITINE
db: BioCyc

Transport78
type: Transport
participant stoichiometry: Compound/PW C000129 Mitochondrial Matrix/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000129 Cytosol/Stoichiometry/1.0
right: L-Acetylcarnitine
spontaneous: false
left: L-Acetylcarnitine
name: L-Acetylcarnitine (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix
conversion direction: LEFT_TO_RIGHT

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Transport74
type: Transport
participant stoichiometry: Compound/PW C000129 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000129 Cytosol/Stoichiometry/1.0
right: L-Acetylcarnitine
spontaneous: false
left: L-Acetylcarnitine
name: L-Acetylcarnitine (→) Transport: Homo sapiens, Cell, Peroxisome to Homo sapiens, Cell, Cytosol
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Reference/UniProt P43155
type: UnificationXref
id: P43155
db: UniProt

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Reference/KEGG Compound C02571
type: UnificationXref
id: C02571
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005739
type: UnificationXref
id: GO:0005739
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/UniProt P33121
type: UnificationXref
id: P33121
db: UniProt

Compound/PW C000497 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dodecanoic acid
stoichiometric coefficient: 1.0

Carnitine O-acetyltransferase
type: Protein
cellular location: Peroxisome
entity reference: Carnitine O-acetyltransferase

SubPathwayInteraction312
type: Interaction
name: SubPathwayReaction
name: SubPathway312Reaction
participant: Lauroyl-CoA
participant: Acetyl-CoA

SubPathwayInteraction310
type: Interaction
name: SubPathway310Reaction
name: SubPathwayReaction
participant: Hexacosanoyl-CoA
participant: Lauroyl-CoA
participant: Acetyl-CoA

Reference/ChemSpider 58623
type: UnificationXref
id: 58623
db: ChemSpider

Carnitine O-palmitoyltransferase 2, mitochondrial
type: ProteinReference
xref: Reference/UniProt P23786
organism: Homo sapiens

Long-chain-fatty-acid--CoA ligase 1
type: ProteinReference
xref: Reference/UniProt P33121
organism: Homo sapiens

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Peroxisome
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005777

Peroxisomal carnitine O-octanoyltransferase
type: ProteinReference
xref: Reference/UniProt Q9UKG9
organism: Homo sapiens

Reference/KEGG Compound C08320
type: UnificationXref
id: C08320
db: KEGG Compound

Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 31009
type: UnificationXref
id: CHEBI:31009
db: ChEBI

Reference/BioCyc TETRACOSANOATE
type: UnificationXref
id: TETRACOSANOATE
db: BioCyc

L-Acetylcarnitine
type: SmallMolecule
cellular location: Peroxisome
entity reference: L-Acetylcarnitine

Mitochondrial Matrix
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005759

Compound/PW C002751 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hexacosanoyl-CoA
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Compound/PW C000129 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Acetylcarnitine
stoichiometric coefficient: 1.0

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

SubPathwayInteraction309
type: Interaction
name: SubPathway309Reaction
name: SubPathwayReaction
participant: Tetracosanoyl-CoA
participant: Acetyl-CoA
participant: Tetradecanoyl-CoA

Compound/PW C000044 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

L-Acetylcarnitine
type: SmallMolecule
cellular location: Mitochondrial Matrix
entity reference: L-Acetylcarnitine

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Reference/PubChem-compound 10917
type: UnificationXref
id: 10917
db: PubChem-compound

Reference/KEGG Compound C02593
type: UnificationXref
id: C02593
db: KEGG Compound

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

ReactionCatalysis1173
type: Catalysis
controller: Long-chain-fatty-acid--CoA ligase 1
controlled: 6.2.1.3
control type: ACTIVATION

ReactionCatalysis1172
type: Catalysis
controller: Long-chain-fatty-acid--CoA ligase 1
controlled: 6.2.1.3
control type: ACTIVATION

Reference/ChemSpider 10455
type: UnificationXref
id: 10455
db: ChemSpider

L-Carnitine
type: SmallMolecule
cellular location: Peroxisome
entity reference: L-Carnitine

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrion
entity reference: Coenzyme A

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Tetracosanoyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetracosanoyl-CoA

Reference/PubChem-compound 10469
type: UnificationXref
id: 10469
db: PubChem-compound

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

TransportCatalysis39
type: Catalysis
controller: Peroxisomal membrane protein
controlled: Transport74
control type: ACTIVATION

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 28866
type: UnificationXref
id: CHEBI:28866
db: ChEBI

Reference/ChEBI CHEBI 64868
type: UnificationXref
id: CHEBI:64868
db: ChEBI

Reference/UniProt O43772
type: UnificationXref
id: O43772
db: UniProt

ChemicalStructure/PW C001928
type: ChemicalStructure
structure format: SMILES

Reference/KEGG Compound C01832
type: UnificationXref
id: C01832
db: KEGG Compound

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Compound/PW C000044 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

TransportCatalysis43
type: Catalysis
controller: Mitochondrial carnitine/acylcarnitine carrier protein
controlled: Transport78
control type: ACTIVATION

Reference/PubChem-compound 165436
type: UnificationXref
id: 165436
db: PubChem-compound

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

ChemicalStructure/PW C000044
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)C[C@H](O)CC([O-])=O

Tetracosanoic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Tetracosanoic acid

Compound/PW C000129 Mitochondrial Matrix/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Acetylcarnitine
stoichiometric coefficient: 1.0

ReactionCatalysis1195
type: Catalysis
controller: Peroxisomal carnitine O-octanoyltransferase
controlled: 2.3.1.137
control type: ACTIVATION

Reference/GENE ONTOLOGY GO 0005777
type: UnificationXref
id: GO:0005777
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 30805
type: UnificationXref
id: CHEBI:30805
db: ChEBI

ReactionCatalysis1197
type: Catalysis
controller: Carnitine O-acetyltransferase
controlled: 2.3.1.7
control type: ACTIVATION

ReactionCatalysis1196
type: Catalysis
controller: Carnitine O-acetyltransferase
controlled: 2.3.1.7
control type: ACTIVATION

Reference/KEGG Compound C16529
type: UnificationXref
id: C16529
db: KEGG Compound

ReactionCatalysis1198
type: Catalysis
controller: Carnitine O-palmitoyltransferase 2, mitochondrial
controlled: 2.3.1.21
control type: ACTIVATION

Compound/PW C000497 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dodecanoic acid
stoichiometric coefficient: 1.0

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Coenzyme A
type: SmallMolecule
cellular location: Peroxisome
entity reference: Coenzyme A

ATP-binding cassette sub-family D
type: Complex
component stoichiometry: Protein/5714/Stoichiometry/1.0
component stoichiometry: Protein/5715/Stoichiometry/1.0
component: ATP-binding cassette sub-family D member 1
component: ATP-binding cassette sub-family D member 2

Reference/UniProt Q9UBJ2
type: UnificationXref
id: Q9UBJ2
db: UniProt

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/CAS 143-07-7
type: UnificationXref
id: 143-07-7
db: CAS

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

Reference/BioCyc (-)o-acetylcarnitine
type: UnificationXref
id: (-)o-acetylcarnitine
db: BioCyc

Long-chain-fatty-acid--CoA ligase 1
type: Protein
cellular location: Cytosol
entity reference: Long-chain-fatty-acid--CoA ligase 1

Reference/ChemSpider 145018
type: UnificationXref
id: 145018
db: ChemSpider

Compound/PW C002751 Peroxisome/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hexacosanoyl-CoA
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002356
type: UnificationXref
id: HMDB0002356
db: HMDB

Reference/UniProt O75381
type: UnificationXref
id: O75381
db: UniProt

Beta oxidation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway310
pathway component: SubPathwayInteraction310
name: SubPathway

6.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001340 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002794 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Tetracosanoyl-CoA
spontaneous: false
EC number: 6.2.1.3
left: Adenosine triphosphate
left: Tetracosanoic acid
left: Coenzyme A
name: Adenosine triphosphate + Coenzyme A + Tetracosanoic acid → Adenosine diphosphate + Tetracosanoyl-CoA
conversion direction: LEFT_TO_RIGHT

Beta oxidation
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway312
pathway component: SubPathwayInteraction312
name: SubPathway

Protein/5715/Stoichiometry/1.0
type: Stoichiometry
physical entity: ATP-binding cassette sub-family D member 2
stoichiometric coefficient: 1.0

6.2.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002751 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001589 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hexacosanoyl-CoA
spontaneous: false
EC number: 6.2.1.3
left: Adenosine triphosphate
left: hexacosanoic acid
left: Coenzyme A
name: Adenosine triphosphate + Coenzyme A + hexacosanoic acid → Adenosine diphosphate + Hexacosanoyl-CoA
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 16347
type: UnificationXref
id: CHEBI:16347
db: ChEBI

Carnitine-Acylcarnitine Translocase Deficiency
type: Pathway
pathway order: PathwaySubPathway/312
pathway order: PathwaySubPathway/310
pathway order: PathwaySubPathway/309
pathway order: PathwayEnzymeReaction/1584
pathway order: PathwayEnzymeReaction/1582
pathway order: PathwayTransport/1631
pathway order: PathwayEnzymeReaction/1633
pathway order: PathwayTransport/1586
pathway order: PathwayTransport/1588
pathway order: PathwayEnzymeReaction/1626
pathway order: PathwayTransport/1635
pathway order: PathwayEnzymeReaction/2512136
pathway order: PathwayTransport/1627
pathway order: PathwayEnzymeReaction/1628
pathway order: PathwayTransport/1629
pathway component: Transport110
pathway component: TransportCatalysis77
pathway component: TransportCatalysis76
pathway component: TransportCatalysis39
pathway component: 2.3.1.7
pathway component: Beta oxidation
pathway component: 6.2.1.3
pathway component: 2.3.1.137
pathway component: Transport114
pathway component: Transport115
pathway component: Transport78
pathway component: TransportCatalysis43
pathway component: Transport74
pathway component: TransportCatalysis81
pathway component: TransportCatalysis80
pathway component: 2.3.1.21
pathway component: ReactionCatalysis1173
pathway component: ReactionCatalysis1195
pathway component: ReactionCatalysis1172
pathway component: Transport109
pathway component: ReactionCatalysis1197
pathway component: ReactionCatalysis1196
pathway component: ReactionCatalysis1198
xref: Reference/SMPDB SMP0000517
xref: Reference/PathWhiz PW000493
organism: Homo sapiens

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PathWhiz PW000493
type: UnificationXref
id: PW000493
db: PathWhiz

Reference/HMDB HMDB0002003
type: UnificationXref
id: HMDB0002003
db: HMDB

Reference/HMDB HMDB0003571
type: UnificationXref
id: HMDB0003571
db: HMDB

Reference/HMDB HMDB0000062
type: UnificationXref
id: HMDB0000062
db: HMDB

Reference/UniProt P33897
type: UnificationXref
id: P33897
db: UniProt

Reference/PubChem-compound 11197
type: UnificationXref
id: 11197
db: PubChem-compound

Peroxisomal carnitine O-octanoyltransferase
type: Protein
cellular location: Peroxisome
entity reference: Peroxisomal carnitine O-octanoyltransferase

hexacosanoic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: hexacosanoic acid

Dodecanoic acid
type: SmallMolecule
cellular location: Peroxisome
entity reference: Dodecanoic acid

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

TransportCatalysis77
type: Catalysis
controller: ATP-binding cassette sub-family D
controlled: Transport110
control type: ACTIVATION

TransportCatalysis76
type: Catalysis
controller: ATP-binding cassette sub-family D
controlled: Transport109
control type: ACTIVATION

Reference/CAS 6244-92-4
type: UnificationXref
id: 6244-92-4
db: CAS

Reference/BioCyc 2-PG
type: UnificationXref
id: 2-PG
db: BioCyc

Reference/CAS 24305-30-4
type: UnificationXref
id: 24305-30-4
db: CAS

Reference/ChemSpider 21243783
type: UnificationXref
id: 21243783
db: ChemSpider

Compound/PW C000940 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Compound/PW C001099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Hexacosanoyl-CoA
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0006459
xref: Reference/ChEBI CHEBI 64868
xref: Reference/PubChem-compound 25202335
xref: Reference/ChemSpider 28184701
chemical formula: C47H86N7O17P3S
molecular weight: 1145.5013
structure: ChemicalStructure/PW C002751

Protein/5712/Stoichiometry/1.0
type: Stoichiometry
physical entity: Peroxisomal membrane protein PEX13
stoichiometric coefficient: 1.0

2.3.1.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000129 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrion/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044 Mitochondrion/Stoichiometry/1.0
right: Coenzyme A
right: Acetyl-CoA
spontaneous: false
EC number: 2.3.1.7
left: L-Acetylcarnitine
left: L-Carnitine
name: L-Acetylcarnitine + L-Carnitine → Acetyl-CoA + Coenzyme A
conversion direction: LEFT_TO_RIGHT

2.3.1.137
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001928 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000497 Peroxisome/Stoichiometry/1.0
right: Coenzyme A
right: Dodecanoic acid
spontaneous: false
EC number: 2.3.1.137
left: Lauroyl-CoA
name: Lauroyl-CoA → Coenzyme A + Dodecanoic acid
conversion direction: LEFT_TO_RIGHT

2.3.1.7
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000129 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Peroxisome/Stoichiometry/1.0
right: Coenzyme A
right: L-Acetylcarnitine
spontaneous: false
EC number: 2.3.1.7
left: L-Carnitine
left: Acetyl-CoA
name: Acetyl-CoA + L-Carnitine → Coenzyme A + L-Acetylcarnitine
conversion direction: LEFT_TO_RIGHT

Hexacosanoyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Hexacosanoyl-CoA

Reference/ChemSpider 3756
type: UnificationXref
id: 3756
db: ChemSpider

Peroxisomal membrane protein PEX14
type: Protein
entity reference: Peroxisomal membrane protein PEX14

ATP-binding cassette sub-family D member 1
type: Protein
entity reference: ATP-binding cassette sub-family D member 1

Reference/CAS 557-59-5
type: UnificationXref
id: 557-59-5
db: CAS

Reference/HMDB HMDB0000638
type: UnificationXref
id: HMDB0000638
db: HMDB

Peroxisomal membrane protein
type: Complex
component stoichiometry: Protein/5713/Stoichiometry/1.0
component stoichiometry: Protein/5712/Stoichiometry/1.0
component: Peroxisomal membrane protein PEX14
component: Peroxisomal membrane protein PEX13

Peroxisomal membrane protein PEX13
type: Protein
entity reference: Peroxisomal membrane protein PEX13

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

ATP-binding cassette sub-family D member 2
type: Protein
entity reference: ATP-binding cassette sub-family D member 2

Compound/PW C001340 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Tetracosanoic acid
stoichiometric coefficient: 1.0

TransportCatalysis81
type: Catalysis
controller: Mitochondrial carnitine/acylcarnitine carrier protein
controlled: Transport115
control type: ACTIVATION

TransportCatalysis80
type: Catalysis
controller: Peroxisomal membrane protein 11C
controlled: Transport114
control type: ACTIVATION

Reference/ChEBI CHEBI 52974
type: UnificationXref
id: CHEBI:52974
db: ChEBI

Hexacosanoyl-CoA
type: SmallMolecule
cellular location: Peroxisome
entity reference: Hexacosanoyl-CoA
name: SubPathwayInput

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Transport109
type: Transport
participant stoichiometry: Compound/PW C002794 Peroxisome/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002794 Cytosol/Stoichiometry/1.0
right: Tetracosanoyl-CoA
spontaneous: false
left: Tetracosanoyl-CoA
name: Tetracosanoyl-CoA (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Peroxisome
conversion direction: LEFT_TO_RIGHT

Compound/PW C000497 Mitochondrion/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dodecanoic acid
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001171
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q96HA9
type: UnificationXref
id: Q96HA9
db: UniProt