Reference/SMPDB SMP0000529
type: UnificationXref
id: SMP0000529
db: SMPDB

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 439162
type: UnificationXref
id: 439162
db: PubChem-compound

Glyceraldehyde
type: SmallMoleculeReference
xref: Reference/ChemSpider 731
xref: Reference/PubChem-compound 751
xref: Reference/ChEBI CHEBI 5445
xref: Reference/CAS 56-82-6
xref: Reference/BioCyc GLYCERALD
xref: Reference/HMDB HMDB0001051
xref: Reference/KEGG Compound C02154
chemical formula: C3H6O3
molecular weight: 90.03169
structure: ChemicalStructure/PW C000828

Reference/ChemSpider 559127
type: UnificationXref
id: 559127
db: ChemSpider

Palmitic acid
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Palmitic acid

Reference/PubChem-compound 439153
type: UnificationXref
id: 439153
db: PubChem-compound

Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Compound/PW C002417 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: TG(16:0/16:0/16:0)
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0003364
type: UnificationXref
id: HMDB0003364
db: HMDB

Compound/PW C003149 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: DG(16:0/16:0/0:0)
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00681
type: UnificationXref
id: C00681
db: KEGG Compound

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Reference/PubChem-compound 644078
type: UnificationXref
id: 644078
db: PubChem-compound

Reference/ChEBI CHEBI 75455
type: UnificationXref
id: CHEBI:75455
db: ChEBI

Reference/ChEBI CHEBI 17594
type: UnificationXref
id: CHEBI:17594
db: ChEBI

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 123409
type: UnificationXref
id: 123409
db: PubChem-compound

Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

DG(16:0/16:0/0:0)
type: SmallMolecule
cellular location: Extracellular Space
entity reference: DG(16:0/16:0/0:0)

1-Acyl-sn-glycerol-3-phosphate acyltransferase alpha
type: Protein
cellular location: Cytosol
entity reference: 1-Acyl-sn-glycerol-3-phosphate acyltransferase alpha

ReactionCatalysis933
type: Catalysis
controller: Hepatic triacylglycerol lipase
controlled: 3.1.1.3
control type: ACTIVATION

Reference/HMDB HMDB0007853
type: UnificationXref
id: HMDB0007853
db: HMDB

ReactionCatalysis934
type: Catalysis
controller: Hepatic triacylglycerol lipase
controlled: 3.1.1.3
control type: ACTIVATION

Lipoprotein lipase
type: Protein
cellular location: Cell Membrane
entity reference: Lipoprotein lipase

Reference/ChemSpider 388334
type: UnificationXref
id: 388334
db: ChemSpider

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Adenosine diphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Adenosine diphosphate

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Compound/PW C001099 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16474
type: UnificationXref
id: CHEBI:16474
db: ChEBI

ChemicalStructure/PW C003149
type: ChemicalStructure
structure format: SMILES

1.1.1.21
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000828 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000085 Cytoplasm/Stoichiometry/1.0
right: Glycerol
right: NADPH
spontaneous: false
EC number: 1.1.1.21
left: Glyceraldehyde
left: NADP
name: Glyceraldehyde + NADP ↔ Glycerol + NADPH
conversion direction: REVERSIBLE

Reaction1151
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000081 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000085 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Glycerol 3-phosphate
right: Adenosine diphosphate
spontaneous: false
left: Adenosine triphosphate
left: Glycerol
name: Adenosine triphosphate + Glycerol → Adenosine diphosphate + Glycerol 3-phosphate
conversion direction: LEFT_TO_RIGHT

Aldehyde dehydrogenase, dimeric NADP-preferring
type: ProteinReference
xref: Reference/UniProt P30838
organism: Homo sapiens

ReactionCatalysis843
type: Catalysis
controller: Aldehyde dehydrogenase, dimeric NADP-preferring
controlled: 1.2.1.5
control type: ACTIVATION

ReactionCatalysis844
type: Catalysis
controller: Aldose reductase
controlled: 1.1.1.21
control type: ACTIVATION

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
type: Complex
component stoichiometry: Protein/782 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Reference/ChemSpider 704
type: UnificationXref
id: 704
db: ChemSpider

Reference/PubChem-compound 11147
type: UnificationXref
id: 11147
db: PubChem-compound

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

2.7.1.31
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000644 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000090 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Glyceric acid
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.31
left: 3-Phosphoglyceric acid
left: Adenosine triphosphate
name: 3-Phosphoglyceric acid + Adenosine triphosphate ↔ Adenosine diphosphate + Glyceric acid
conversion direction: REVERSIBLE

ReactionCatalysis836
type: Catalysis
controller: Glycerate kinase
controlled: 2.7.1.31
control type: ACTIVATION

Compound/PW C003904 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: LysoPA(16:0/0:0)
stoichiometric coefficient: 1.0

1.2.1.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000090 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000146 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000828 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000143 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: Glyceraldehyde
right: NADPH
spontaneous: false
EC number: 1.2.1.5
left: Glyceric acid
left: NADP
left: Water
name: Glyceric acid + NADP + Water ↔ Glyceraldehyde + NADPH
conversion direction: REVERSIBLE

Reference/ChEBI CHEBI 237189
type: UnificationXref
id: CHEBI:237189
db: ChEBI

Reference/BioCyc ACYL-SN-GLYCEROL-3P
type: UnificationXref
id: ACYL-SN-GLYCEROL-3P
db: BioCyc

SubPathwayInteraction164
type: Interaction
name: SubPathway164Reaction
name: SubPathwayReaction
participant: 3-Phosphoglyceric acid

SubPathwayInteraction165
type: Interaction
name: SubPathwayReaction
name: SubPathway165Reaction
participant: Palmitic acid

Reference/KEGG Compound C00116
type: UnificationXref
id: C00116
db: KEGG Compound

Compound/PW C000146 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Hydroquinone
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Hydroquinone

Reference/KEGG Compound C00111
type: UnificationXref
id: C00111
db: KEGG Compound

1.1.5.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001860 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000081 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001134 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001632 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Hydroquinone
right: Glycerol 3-phosphate
spontaneous: false
EC number: 1.1.5.3
left: Quinone
left: Dihydroxyacetone phosphate
name: Dihydroxyacetone phosphate + Quinone → Glycerol 3-phosphate + Hydroquinone
conversion direction: LEFT_TO_RIGHT

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00472
type: UnificationXref
id: C00472
db: KEGG Compound

Lipid phosphate phosphohydrolase 2
type: ProteinReference
xref: Reference/UniProt O43688
organism: Homo sapiens

Reference/KEGG Compound C00597
type: UnificationXref
id: C00597
db: KEGG Compound

Reference/ChEBI CHEBI 73246
type: UnificationXref
id: CHEBI:73246
db: ChEBI

2.3.1.51
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001031 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003149 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002417 Cytosol/Stoichiometry/1.0
right: Coenzyme A
right: TG(16:0/16:0/16:0)
spontaneous: false
EC number: 2.3.1.51
left: DG(16:0/16:0/0:0)
left: Palmitoyl-CoA
name: DG(16:0/16:0/0:0) + Palmitoyl-CoA → Coenzyme A + TG(16:0/16:0/16:0)
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P15121
type: UnificationXref
id: P15121
db: UniProt

Reaction1175
type: BiochemicalReaction
participant stoichiometry: Compound/PW C003149 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003149 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000531 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000531 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: PA(16:0/16:0)
right: Adenosine diphosphate
spontaneous: false
left: DG(16:0/16:0/0:0)
left: Adenosine triphosphate
name: Adenosine triphosphate + DG(16:0/16:0/0:0) → Adenosine diphosphate + PA(16:0/16:0)
conversion direction: LEFT_TO_RIGHT

3.1.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001104 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003149 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000531 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Phosphate
right: DG(16:0/16:0/0:0)
spontaneous: false
EC number: 3.1.3.4
left: PA(16:0/16:0)
name: PA(16:0/16:0) → DG(16:0/16:0/0:0) + Phosphate
conversion direction: LEFT_TO_RIGHT

Hepatic triacylglycerol lipase
type: ProteinReference
xref: Reference/UniProt P11150
organism: Homo sapiens

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/KEGG Compound C00249
type: UnificationXref
id: C00249
db: KEGG Compound

Reference/KEGG Compound C00006
type: UnificationXref
id: C00006
db: KEGG Compound

Reference/ChEBI CHEBI 18009
type: UnificationXref
id: CHEBI:18009
db: ChEBI

Reference/PubChem-compound 439194
type: UnificationXref
id: 439194
db: PubChem-compound

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C00005
type: UnificationXref
id: C00005
db: KEGG Compound

Reference/KEGG Compound C00004
type: UnificationXref
id: C00004
db: KEGG Compound

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/KEGG Compound C00003
type: UnificationXref
id: C00003
db: KEGG Compound

NADPH
type: SmallMolecule
cellular location: Cytosol
entity reference: NADPH

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

NADP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADP

LysoPA(16:0/0:0)
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15799
xref: Reference/HMDB HMDB0007853
xref: Reference/KEGG Compound C00681
xref: Reference/BioCyc ACYL-SN-GLYCEROL-3P
xref: Reference/ChemSpider 4925335
xref: Reference/PubChem-compound 6419701
chemical formula: C19H39O7P
molecular weight: 410.24335
structure: ChemicalStructure/PW C003904

Reference/UniProt Q9HCL2
type: UnificationXref
id: Q9HCL2
db: UniProt

Lipid phosphate phosphohydrolase 1
type: ProteinReference
xref: Reference/UniProt O14494
organism: BiologicalState10

Lipid phosphate phosphohydrolase 2
type: Complex
component stoichiometry: Protein/225 Mitochondrial Outer Membrane/Stoichiometry/2.0
cellular location: Mitochondrial Outer Membrane
component: Lipid phosphate phosphohydrolase 2

1.1.1.8
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001134 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000081 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
right: NADH
right: Dihydroxyacetone phosphate
spontaneous: false
EC number: 1.1.1.8
left: Glycerol 3-phosphate
left: NAD
name: Glycerol 3-phosphate + NAD ↔ Dihydroxyacetone phosphate + NADH
conversion direction: REVERSIBLE

ReactionCatalysis855
type: Catalysis
controller: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
controlled: 1.1.1.8
control type: ACTIVATION

Reference/HMDB HMDB0005356
type: UnificationXref
id: HMDB0005356
db: HMDB

PA(16:0/16:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: PA(16:0/16:0)

Coenzyme A
type: SmallMolecule
cellular location: Cytosol
entity reference: Coenzyme A

NAD
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15846
xref: Reference/HMDB HMDB0000902
xref: Reference/CAS 53-84-9
xref: Reference/KEGG Compound C00003
xref: Reference/PubChem-compound 5893
xref: Reference/BioCyc NAD
xref: Reference/ChemSpider 5682
chemical formula: C21H27N7O14P2
molecular weight: 663.10913
structure: ChemicalStructure/PW C000721

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

Reference/HMDB HMDB0000902
type: UnificationXref
id: HMDB0000902
db: HMDB

Reference/KEGG Compound C00258
type: UnificationXref
id: C00258
db: KEGG Compound

TG(16:0/16:0/16:0)
type: SmallMolecule
cellular location: Cytosol
entity reference: TG(16:0/16:0/16:0)

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/BioCyc NAD(P)
type: UnificationXref
id: NAD(P)
db: BioCyc

Reference/ChemSpider 110006
type: UnificationXref
id: 110006
db: ChemSpider

ReactionCatalysis526
type: Catalysis
controller: Lipid phosphate phosphohydrolase 1
controlled: 3.1.3.4
control type: ACTIVATION

Reference/PubChem-compound 6419701
type: UnificationXref
id: 6419701
db: PubChem-compound

ReactionCatalysis883
type: Catalysis
controller: Glycerol-3-phosphate dehydrogenase, mitochondrial
controlled: 1.1.5.3
control type: ACTIVATION

Compound/PW C001134 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroxyacetone phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 388308
type: UnificationXref
id: 388308
db: ChemSpider

Compound/PW C000644 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-Phosphoglyceric acid
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Coenzyme A

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/CAS 53-84-9
type: UnificationXref
id: 53-84-9
db: CAS

1-Acyl-sn-glycerol-3-phosphate acyltransferase alpha
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: 1-Acyl-sn-glycerol-3-phosphate acyltransferase alpha

MG(0:0/16:0/0:0)
type: SmallMoleculeReference
xref: Reference/PubChem-compound 123409
xref: Reference/ChemSpider 110006
xref: Reference/HMDB HMDB0011533
xref: Reference/ChEBI CHEBI 75455
chemical formula: C19H38O4
molecular weight: 330.277
structure: ChemicalStructure/PW C007130

Compound/PW C000828 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyceraldehyde
stoichiometric coefficient: 1.0

NADP
type: SmallMolecule
cellular location: Cytosol
entity reference: NADP

ReactionCatalysis876
type: Catalysis
controller: Lipid phosphate phosphohydrolase 2
controlled: 3.1.3.4
control type: ACTIVATION

ReactionCatalysis877
type: Catalysis
controller: 1-Acyl-sn-glycerol-3-phosphate acyltransferase alpha
controlled: 2.3.1.51
control type: ACTIVATION

Reference/BioCyc DIACYLGLYCEROL
type: UnificationXref
id: DIACYLGLYCEROL
db: BioCyc

Hydroquinone
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0002434
xref: Reference/ChemSpider 764
xref: Reference/PubChem-compound 785
xref: Reference/CAS 123-31-9
xref: Reference/BioCyc 236-TRICHLOROHYDROQUINONE
xref: Reference/ChEBI CHEBI 17594
xref: Reference/KEGG Compound C00530
chemical formula: C6H6O2
molecular weight: 110.03678
structure: ChemicalStructure/PW C001632

Reference/KEGG Compound C00154
type: UnificationXref
id: C00154
db: KEGG Compound

Lipoprotein lipase
type: ProteinReference
xref: Reference/UniProt P06858
organism: Homo sapiens

ChemicalStructure/PW C001144
type: ChemicalStructure
structure format: SMILES

Glycerol-3-phosphate acyltransferase 1, mitochondrial
type: ProteinReference
xref: Reference/UniProt Q9HCL2
organism: BiologicalState10

Reference/HMDB HMDB0002434
type: UnificationXref
id: HMDB0002434
db: HMDB

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
type: ProteinReference
xref: Reference/UniProt P21695
organism: Homo sapiens

Glycerol 3-phosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Glycerol 3-phosphate

Reference/HMDB HMDB0000139
type: UnificationXref
id: HMDB0000139
db: HMDB

Reference/UniProt P06858
type: UnificationXref
id: P06858
db: UniProt

Adenosine triphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/HMDB HMDB0000131
type: UnificationXref
id: HMDB0000131
db: HMDB

Reference/PubChem-compound 753
type: UnificationXref
id: 753
db: PubChem-compound

Reference/PubChem-compound 751
type: UnificationXref
id: 751
db: PubChem-compound

Reference/BioCyc GLYCEROL
type: UnificationXref
id: GLYCEROL
db: BioCyc

Reference/KEGG Compound C00165
type: UnificationXref
id: C00165
db: KEGG Compound

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

Reference/ChemSpider 648
type: UnificationXref
id: 648
db: ChemSpider

Reference/UniProt P30838
type: UnificationXref
id: P30838
db: UniProt

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 764
type: UnificationXref
id: 764
db: ChemSpider

ChemicalStructure/PW C001031
type: ChemicalStructure
structure format: SMILES

Compound/PW C001144 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

Protein/782 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
stoichiometric coefficient: 2.0

Reference/HMDB HMDB0001473
type: UnificationXref
id: HMDB0001473
db: HMDB

Reference/PubChem-compound 785
type: UnificationXref
id: 785
db: PubChem-compound

3-Phosphoglyceric acid
type: SmallMoleculeReference
xref: Reference/BioCyc G3P
xref: Reference/PubChem-compound 724
xref: Reference/ChEBI CHEBI 17050
xref: Reference/ChemSpider 704
xref: Reference/CAS 820-11-1
xref: Reference/KEGG Compound C00597
xref: Reference/HMDB HMDB0000807
chemical formula: C3H7O7P
molecular weight: 185.99294
structure: ChemicalStructure/PW C000644

Lipid phosphate phosphohydrolase 2
type: Protein
cellular location: Mitochondrial Outer Membrane
entity reference: Lipid phosphate phosphohydrolase 2

Reference/PubChem-compound 668
type: UnificationXref
id: 668
db: PubChem-compound

Adenosine diphosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Adenosine diphosphate

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

3.1.3.4
type: BiochemicalReaction
participant stoichiometry: Compound/PW C003149 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000531 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
right: Phosphate
right: DG(16:0/16:0/0:0)
spontaneous: false
EC number: 3.1.3.4
left: Water
left: PA(16:0/16:0)
name: PA(16:0/16:0) + Water → DG(16:0/16:0/0:0) + Phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C001420 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001487
type: UnificationXref
id: HMDB0001487
db: HMDB

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Water

Quinone
type: SmallMoleculeReference
xref: Reference/ChemSpider 4489
xref: Reference/CAS 106-51-4
xref: Reference/KEGG Compound C00472
xref: Reference/ChEBI CHEBI 16509
xref: Reference/BioCyc CPD-8130
xref: Reference/PubChem-compound 4650
xref: Reference/HMDB HMDB0003364
chemical formula: C6H4O2
molecular weight: 108.021126
structure: ChemicalStructure/PW C001860

Compound/PW C003904 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: LysoPA(16:0/0:0)
stoichiometric coefficient: 1.0

PA(16:0/16:0)
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00416
xref: Reference/BioCyc L-PHOSPHATIDATE
xref: Reference/ChemSpider 393518
xref: Reference/HMDB HMDB0000674
xref: Reference/PubChem-compound 446066
xref: Reference/CAS 7091-44-3
xref: Reference/ChEBI CHEBI 73246
chemical formula: C35H69O8P
molecular weight: 648.473
structure: ChemicalStructure/PW C000531

Reference/ChEBI CHEBI 77393
type: UnificationXref
id: CHEBI:77393
db: ChEBI

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

Reference/CAS 57-10-3
type: UnificationXref
id: 57-10-3
db: CAS

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
type: UnificationXref
id: DIHYDROXY-ACETONE-PHOSPHATE
db: BioCyc

Palmitoyl-CoA
type: SmallMolecule
cellular location: Cytosol
entity reference: Palmitoyl-CoA

BiologicalState10
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver
tissue: Liver

Hepatic triacylglycerol lipase
type: Protein
cellular location: Cytosol
entity reference: Hepatic triacylglycerol lipase

Compound/PW C001031 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitoyl-CoA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17050
type: UnificationXref
id: CHEBI:17050
db: ChEBI

ChemicalStructure/PW C001134
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)COP(O)(O)=O

Dihydroxyacetone phosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Dihydroxyacetone phosphate

Adenosine triphosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Adenosine triphosphate

3-Phosphoglyceric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: 3-Phosphoglyceric acid
name: SubPathwayOutput

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C001031 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitoyl-CoA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 724
type: UnificationXref
id: 724
db: PubChem-compound

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Compound/PW C002417 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: TG(16:0/16:0/16:0)
stoichiometric coefficient: 1.0

Reference/ChemSpider 733
type: UnificationXref
id: 733
db: ChemSpider

Reference/ChemSpider 731
type: UnificationXref
id: 731
db: ChemSpider

ChemicalStructure/PW C000090
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@@H](O)C(O)=O

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Glycerate kinase
type: ProteinReference
xref: Reference/UniProt Q8IVS8
organism: Homo sapiens

Glycerol-3-phosphate dehydrogenase, mitochondrial
type: Protein
cellular location: Mitochondrial Outer Membrane
entity reference: Glycerol-3-phosphate dehydrogenase, mitochondrial

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Compound/PW C003149 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: DG(16:0/16:0/0:0)
stoichiometric coefficient: 1.0

Lipoprotein lipase
type: Protein
cellular location: Extracellular Space
entity reference: Lipoprotein lipase

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

TG(16:0/16:0/16:0)
type: SmallMoleculeReference
xref: Reference/CAS 555-44-2
xref: Reference/ChEBI CHEBI 77393
xref: Reference/HMDB HMDB0005356
xref: Reference/PubChem-compound 11147
xref: Reference/ChemSpider 10674
chemical formula: C51H98O6
molecular weight: 806.7363
structure: ChemicalStructure/PW C002417

Reference/BioCyc G3P
type: UnificationXref
id: G3P
db: BioCyc

Reference/ChemSpider 960
type: UnificationXref
id: 960
db: ChemSpider

Compound/PW C001104 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/BioCyc GLYCEROL-3P
type: UnificationXref
id: GLYCEROL-3P
db: BioCyc

Reference/KEGG Compound C00093
type: UnificationXref
id: C00093
db: KEGG Compound

Reference/UniProt O43688
type: UnificationXref
id: O43688
db: UniProt

Reference/PubChem-compound 985
type: UnificationXref
id: 985
db: PubChem-compound

3-Phosphoglyceric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: 3-Phosphoglyceric acid

Compound/PW C000721 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

Compound/PW C002417 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: TG(16:0/16:0/16:0)
stoichiometric coefficient: 1.0

Reference/BioCyc 2-PG
type: UnificationXref
id: 2-PG
db: BioCyc

Reference/KEGG Compound C02154
type: UnificationXref
id: C02154
db: KEGG Compound

LysoPA(16:0/0:0)
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: LysoPA(16:0/0:0)

Reference/PubChem-compound 22833512
type: UnificationXref
id: 22833512
db: PubChem-compound

Compound/PW C003149 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: DG(16:0/16:0/0:0)
stoichiometric coefficient: 1.0

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C000085 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycerol
stoichiometric coefficient: 1.0

Reference/BioCyc NADH
type: UnificationXref
id: NADH
db: BioCyc

Compound/PW C001034 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc NAD
type: UnificationXref
id: NAD
db: BioCyc

ChemicalStructure/PW C000085
type: ChemicalStructure
structure format: SMILES
structure data: OCC(O)CO

Phosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Phosphate

ReactionCatalysis917
type: Catalysis
controller: Lipoprotein lipase
controlled: 3.1.1.34
control type: ACTIVATION

NAD
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NAD

Reference/HMDB HMDB0001051
type: UnificationXref
id: HMDB0001051
db: HMDB

Reference/CAS 820-11-1
type: UnificationXref
id: 820-11-1
db: CAS

ChemicalStructure/PW C000081
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@@H](O)COP(O)(O)=O

Reference/ChemSpider 17215925
type: UnificationXref
id: 17215925
db: ChemSpider

Compound/PW C000081 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycerol 3-phosphate
stoichiometric coefficient: 1.0

Protein/225 Mitochondrial Outer Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Lipid phosphate phosphohydrolase 2
stoichiometric coefficient: 2.0

Reference/ChEBI CHEBI 5445
type: UnificationXref
id: CHEBI:5445
db: ChEBI

Compound/PW C000414 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Coenzyme A

Reference/CAS 56-81-5
type: UnificationXref
id: 56-81-5
db: CAS

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ReactionCatalysis1329
type: Catalysis
controller: Hepatic triacylglycerol lipase
controlled: 3.1.1.3
control type: ACTIVATION

Reference/CAS 473-81-4
type: UnificationXref
id: 473-81-4
db: CAS

Reference/CAS 555-44-2
type: UnificationXref
id: 555-44-2
db: CAS

Compound/PW C003149 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: DG(16:0/16:0/0:0)
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Compound/PW C000143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Dihydroxyacetone phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc DIHYDROXY-ACETONE-PHOSPHATE
xref: Reference/PubChem-compound 668
xref: Reference/ChEBI CHEBI 16108
xref: Reference/KEGG Compound C00111
xref: Reference/CAS 57-04-5
xref: Reference/ChemSpider 648
xref: Reference/HMDB HMDB0001473
chemical formula: C3H7O6P
molecular weight: 169.99803
structure: ChemicalStructure/PW C001134

Glycolysis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway164
pathway component: SubPathwayInteraction164
xref: Reference/SMPDB SMP0000040
xref: Reference/PathWhiz PW000146
name: SubPathway

Compound/PW C000081 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycerol 3-phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15846
type: UnificationXref
id: CHEBI:15846
db: ChEBI

Compound/PW C000090 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyceric acid
stoichiometric coefficient: 1.0

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/BioCyc PALMITYL-COA
type: UnificationXref
id: PALMITYL-COA
db: BioCyc

Reference/CAS 53-59-8
type: UnificationXref
id: 53-59-8
db: CAS

Glyceric acid
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glyceric acid

Compound/PW C000145 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitic acid
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Palmitic acid
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Palmitic acid

Reference/HMDB HMDB0000674
type: UnificationXref
id: HMDB0000674
db: HMDB

Reference/CAS 56-82-6
type: UnificationXref
id: 56-82-6
db: CAS

Fatty Acid Metabolism
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway165
pathway component: SubPathwayInteraction165
xref: Reference/SMPDB SMP0000051
xref: Reference/PathWhiz PW000023
name: SubPathway

Compound/PW C000145 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16908
type: UnificationXref
id: CHEBI:16908
db: ChEBI

Compound/PW C001034 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

1-Acyl-sn-glycerol-3-phosphate acyltransferase alpha
type: ProteinReference
xref: Reference/UniProt Q99943
organism: BiologicalState10

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/ChEBI CHEBI 32398
type: UnificationXref
id: CHEBI:32398
db: ChEBI

Reference/PubChem-compound 4650
type: UnificationXref
id: 4650
db: PubChem-compound

NADPH
type: SmallMoleculeReference
xref: Reference/CAS 53-57-6
xref: Reference/HMDB HMDB0000221
xref: Reference/PubChem-compound 22833512
xref: Reference/BioCyc NADPH
xref: Reference/ChemSpider 17215925
xref: Reference/KEGG Compound C00005
xref: Reference/ChEBI CHEBI 16474
chemical formula: C21H30N7O17P3
molecular weight: 745.0911
structure: ChemicalStructure/PW C000146

Palmitic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 985
xref: Reference/KEGG Compound C00249
xref: Reference/ChemSpider 960
xref: Reference/ChEBI CHEBI 15756
xref: Reference/BioCyc CPD-8475
xref: Reference/CAS 57-10-3
xref: Reference/HMDB HMDB0000220
chemical formula: C16H32O2
molecular weight: 256.24023
structure: ChemicalStructure/PW C000145

Aldehyde dehydrogenase, dimeric NADP-preferring
type: Protein
cellular location: Cytosol
entity reference: Aldehyde dehydrogenase, dimeric NADP-preferring

NADP
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00006
xref: Reference/CAS 53-59-8
xref: Reference/BioCyc NAD(P)
xref: Reference/HMDB HMDB0000217
xref: Reference/ChEBI CHEBI 18009
xref: Reference/PubChem-compound 5886
xref: Reference/ChemSpider 5675
chemical formula: C21H28N7O17P3
molecular weight: 743.07544
structure: ChemicalStructure/PW C000143

Reference/UniProt P11150
type: UnificationXref
id: P11150
db: UniProt

Compound/PW C001031 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitoyl-CoA
stoichiometric coefficient: 1.0

Reference/BioCyc NADPH
type: UnificationXref
id: NADPH
db: BioCyc

Reference/ChEBI CHEBI 15525
type: UnificationXref
id: CHEBI:15525
db: ChEBI

Reference/BioCyc 236-TRICHLOROHYDROQUINONE
type: UnificationXref
id: 236-TRICHLOROHYDROQUINONE
db: BioCyc

Glyceric acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Glyceric acid

LysoPA(16:0/0:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: LysoPA(16:0/0:0)

Palmitoyl-CoA
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Palmitoyl-CoA

Reference/CAS 58-68-4
type: UnificationXref
id: 58-68-4
db: CAS

Reference/SMPDB SMP0000040
type: UnificationXref
id: SMP0000040
db: SMPDB

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0000217
type: UnificationXref
id: HMDB0000217
db: HMDB

Compound/PW C000146 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/HMDB HMDB0007098
type: UnificationXref
id: HMDB0007098
db: HMDB

Reference/PubChem-compound 446066
type: UnificationXref
id: 446066
db: PubChem-compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/CAS 1763-10-6
type: UnificationXref
id: 1763-10-6
db: CAS

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

ChemicalStructure/PW C000143
type: ChemicalStructure
structure format: SMILES

Compound/PW C000090 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyceric acid
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000221
type: UnificationXref
id: HMDB0000221
db: HMDB

Reference/SMPDB SMP0000051
type: UnificationXref
id: SMP0000051
db: SMPDB

Glycerol 3-phosphate
type: SmallMoleculeReference
xref: Reference/BioCyc GLYCEROL-3P
xref: Reference/HMDB HMDB0000126
xref: Reference/ChemSpider 388308
xref: Reference/CAS 17989-41-2
xref: Reference/KEGG Compound C00093
xref: Reference/ChEBI CHEBI 15978
xref: Reference/PubChem-compound 439162
chemical formula: C3H9O6P
molecular weight: 172.01367
structure: ChemicalStructure/PW C000081

ChemicalStructure/PW C000146
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q99943
type: UnificationXref
id: Q99943
db: UniProt

ChemicalStructure/PW C000145
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCC(O)=O

Glycerol 3-phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glycerol 3-phosphate

Reference/CAS 57-04-5
type: UnificationXref
id: 57-04-5
db: CAS

Glycerol
type: SmallMoleculeReference
xref: Reference/PubChem-compound 753
xref: Reference/KEGG Compound C00116
xref: Reference/ChEBI CHEBI 17522
xref: Reference/CAS 56-81-5
xref: Reference/BioCyc GLYCEROL
xref: Reference/HMDB HMDB0000131
xref: Reference/ChemSpider 733
chemical formula: C3H8O3
molecular weight: 92.04734
structure: ChemicalStructure/PW C000085

Reference/HMDB HMDB0000220
type: UnificationXref
id: HMDB0000220
db: HMDB

Reference/CAS 53-57-6
type: UnificationXref
id: 53-57-6
db: CAS

2.3.1.51
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001031 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003904 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003904 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000531 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000531 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: PA(16:0/16:0)
right: Coenzyme A
spontaneous: false
EC number: 2.3.1.51
left: Palmitoyl-CoA
left: LysoPA(16:0/0:0)
name: LysoPA(16:0/0:0) + Palmitoyl-CoA → Coenzyme A + PA(16:0/16:0)
conversion direction: LEFT_TO_RIGHT

Compound/PW C000085 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycerol
stoichiometric coefficient: 1.0

Reference/BioCyc L-PHOSPHATIDATE
type: UnificationXref
id: L-PHOSPHATIDATE
db: BioCyc

TG(16:0/16:0/16:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: TG(16:0/16:0/16:0)

NADH
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001487
xref: Reference/CAS 58-68-4
xref: Reference/PubChem-compound 439153
xref: Reference/BioCyc NADH
xref: Reference/ChemSpider 388299
xref: Reference/KEGG Compound C00004
xref: Reference/ChEBI CHEBI 16908
chemical formula: C21H29N7O14P2
molecular weight: 665.12476
structure: ChemicalStructure/PW C001144

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

2.3.1.15
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001031 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000081 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003904 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000081 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003904 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099 Mitochondrial Outer Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001031 Mitochondrial Outer Membrane/Stoichiometry/1.0
right: Coenzyme A
right: LysoPA(16:0/0:0)
spontaneous: false
EC number: 2.3.1.15
left: Glycerol 3-phosphate
left: Palmitoyl-CoA
name: Glycerol 3-phosphate + Palmitoyl-CoA → Coenzyme A + LysoPA(16:0/0:0)
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15978
type: UnificationXref
id: CHEBI:15978
db: ChEBI

Reference/GENE ONTOLOGY GO 0005741
type: UnificationXref
id: GO:0005741
db: GENE ONTOLOGY

Compound/PW C000531 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PA(16:0/16:0)
stoichiometric coefficient: 1.0

Compound/PW C000531 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: PA(16:0/16:0)
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15756
type: UnificationXref
id: CHEBI:15756
db: ChEBI

ChemicalStructure/PW C002417
type: ChemicalStructure
structure format: SMILES

Palmitoyl-CoA
type: SmallMoleculeReference
xref: Reference/PubChem-compound 15667
xref: Reference/ChemSpider 14902
xref: Reference/HMDB HMDB0001338
xref: Reference/ChEBI CHEBI 15525
xref: Reference/KEGG Compound C00154
xref: Reference/CAS 1763-10-6
xref: Reference/BioCyc PALMITYL-COA
chemical formula: C37H66N7O17P3S
molecular weight: 1005.34485
structure: ChemicalStructure/PW C001031

PA(16:0/16:0)
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: PA(16:0/16:0)

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/HMDB HMDB0000126
type: UnificationXref
id: HMDB0000126
db: HMDB

Reference/HMDB HMDB0001338
type: UnificationXref
id: HMDB0001338
db: HMDB

Reference/PathWhiz PW000505
type: UnificationXref
id: PW000505
db: PathWhiz

Reference/CAS 7091-44-3
type: UnificationXref
id: 7091-44-3
db: CAS

Reference/ChemSpider 4925335
type: UnificationXref
id: 4925335
db: ChemSpider

Mitochondrial Outer Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005741

Quinone
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Quinone

Glycerol 3-phosphate
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: Glycerol 3-phosphate

Endoplasmic Reticulum Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005789

NADH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADH

ChemicalStructure/PW C000721
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Reference/HMDB HMDB0000807
type: UnificationXref
id: HMDB0000807
db: HMDB

Reference/ChemSpider 5682
type: UnificationXref
id: 5682
db: ChemSpider

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/UniProt P21695
type: UnificationXref
id: P21695
db: UniProt

DG(16:0/16:0/0:0)
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0007098
xref: Reference/BioCyc DIACYLGLYCEROL
xref: Reference/KEGG Compound C00165
xref: Reference/CAS 30334-71-5
xref: Reference/ChEBI CHEBI 237189
xref: Reference/PubChem-compound 644078
xref: Reference/ChemSpider 559127
chemical formula: C35H68O5
molecular weight: 568.50665
structure: ChemicalStructure/PW C003149

Compound/PW C001632 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydroquinone
stoichiometric coefficient: 1.0

Reference/CAS 30334-71-5
type: UnificationXref
id: 30334-71-5
db: CAS

Hepatic triacylglycerol lipase
type: Protein
cellular location: Extracellular Space
entity reference: Hepatic triacylglycerol lipase

Compound/PW C001860 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Quinone
stoichiometric coefficient: 1.0

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Reference/BioCyc CPD-8475
type: UnificationXref
id: CPD-8475
db: BioCyc

Reference/ChemSpider 5675
type: UnificationXref
id: 5675
db: ChemSpider

Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
type: Protein
cellular location: Cytoplasm
entity reference: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Compound/PW C001134 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydroxyacetone phosphate
stoichiometric coefficient: 1.0

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

ChemicalStructure/PW C007130
type: ChemicalStructure
structure format: SMILES
structure data: [H]C(CO)(CO)OC(=O)CCCCCCCCCCCCCCC

Compound/PW C000414 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q8IVS8
type: UnificationXref
id: Q8IVS8
db: UniProt

NADPH
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NADPH

ReactionCatalysis576
type: Catalysis
controller: 1-Acyl-sn-glycerol-3-phosphate acyltransferase alpha
controlled: 2.3.1.51
control type: ACTIVATION

ChemicalStructure/PW C000828
type: ChemicalStructure
structure format: SMILES
structure data: OCC(O)C=O

Reference/ChemSpider 14902
type: UnificationXref
id: 14902
db: ChemSpider

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

ReactionCatalysis574
type: Catalysis
controller: Glycerol-3-phosphate acyltransferase 1, mitochondrial
controlled: 2.3.1.15
control type: ACTIVATION

Phosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Phosphate

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reference/ChemSpider 388299
type: UnificationXref
id: 388299
db: ChemSpider

Glycerol
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Glycerol

Glyceric acid
type: SmallMoleculeReference
xref: Reference/ChemSpider 388334
xref: Reference/HMDB HMDB0000139
xref: Reference/PubChem-compound 439194
xref: Reference/ChEBI CHEBI 32398
xref: Reference/KEGG Compound C00258
xref: Reference/BioCyc 2-PG
xref: Reference/CAS 473-81-4
chemical formula: C3H6O4
molecular weight: 106.02661
structure: ChemicalStructure/PW C000090

Reference/GENE ONTOLOGY GO 0005789
type: UnificationXref
id: GO:0005789
db: GENE ONTOLOGY

Reference/ChEBI CHEBI 16509
type: UnificationXref
id: CHEBI:16509
db: ChEBI

Water
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Water

Dihydroxyacetone phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Dihydroxyacetone phosphate

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Aldose reductase
type: Protein
cellular location: Cytoplasm
entity reference: Aldose reductase

Reference/ChEBI CHEBI 15799
type: UnificationXref
id: CHEBI:15799
db: ChEBI

Reference/ChemSpider 4489
type: UnificationXref
id: 4489
db: ChemSpider

Reference/BioCyc CPD-8130
type: UnificationXref
id: CPD-8130
db: BioCyc

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Palmitic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Palmitic acid
name: SubPathwayInput

Glyceraldehyde
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glyceraldehyde

Compound/PW C000145 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Palmitic acid
stoichiometric coefficient: 1.0

Reference/BioCyc GLYCERALD
type: UnificationXref
id: GLYCERALD
db: BioCyc

Reference/CAS 123-31-9
type: UnificationXref
id: 123-31-9
db: CAS

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Palmitoyl-CoA
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: Palmitoyl-CoA

Reference/ChemSpider 10674
type: UnificationXref
id: 10674
db: ChemSpider

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PathWhiz PW000023
type: UnificationXref
id: PW000023
db: PathWhiz

Reference/PathWhiz PW000146
type: UnificationXref
id: PW000146
db: PathWhiz

ChemicalStructure/PW C000644
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP(O)(O)=O)C(O)=O

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5893
type: UnificationXref
id: 5893
db: PubChem-compound

Compound/PW C001104 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

DG(16:0/16:0/0:0)
type: SmallMolecule
cellular location: Cell Membrane
entity reference: DG(16:0/16:0/0:0)

ChemicalStructure/PW C000531
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C001860
type: ChemicalStructure
structure format: SMILES
structure data: O=C1C=CC(=O)C=C1

3.1.1.34
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003149 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003149 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002417 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000145 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002417 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000145 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Palmitic acid
right: DG(16:0/16:0/0:0)
spontaneous: false
EC number: 3.1.1.34
left: TG(16:0/16:0/16:0)
left: Water
name: TG(16:0/16:0/16:0) + Water → DG(16:0/16:0/0:0) + Palmitic acid
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

MG(0:0/16:0/0:0)
type: SmallMolecule
cellular location: Extracellular Space
entity reference: MG(0:0/16:0/0:0)

Reference/ChemSpider 393518
type: UnificationXref
id: 393518
db: ChemSpider

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

DG(16:0/16:0/0:0)
type: SmallMolecule
cellular location: Mitochondrial Outer Membrane
entity reference: DG(16:0/16:0/0:0)

Reference/CAS 17989-41-2
type: UnificationXref
id: 17989-41-2
db: CAS

Reference/ChEBI CHEBI 16108
type: UnificationXref
id: CHEBI:16108
db: ChEBI

DG(16:0/16:0/0:0)
type: SmallMolecule
cellular location: Endoplasmic Reticulum Membrane
entity reference: DG(16:0/16:0/0:0)

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/PubChem-compound 5886
type: UnificationXref
id: 5886
db: PubChem-compound

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C001632
type: ChemicalStructure
structure format: SMILES
structure data: OC1=CC=C(O)C=C1

Glycerol-3-phosphate dehydrogenase, mitochondrial
type: ProteinReference
xref: Reference/UniProt P43304
organism: Homo sapiens

Glycerol-3-phosphate acyltransferase 1, mitochondrial
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Glycerol-3-phosphate acyltransferase 1, mitochondrial

Reference/KEGG Compound C00416
type: UnificationXref
id: C00416
db: KEGG Compound

Compound/PW C003149 Endoplasmic Reticulum Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: DG(16:0/16:0/0:0)
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 17522
type: UnificationXref
id: CHEBI:17522
db: ChEBI

D-Glyceric Acidura
type: Pathway
pathway order: PathwayEnzymeReaction/211561
pathway order: PathwayEnzymeReaction/211562
pathway order: PathwayEnzymeReaction/211563
pathway order: PathwayEnzymeReaction/211564
pathway order: PathwaySubPathway/164
pathway order: PathwaySubPathway/165
pathway order: PathwayEnzymeReaction/211560
pathway order: PathwayEnzymeReaction/1097
pathway order: PathwayEnzymeReaction/3311
pathway order: PathwayEnzymeReaction/3312
pathway order: PathwayEnzymeReaction/1187
pathway order: PathwayEnzymeReaction/3306
pathway order: PathwayEnzymeReaction/3307
pathway order: PathwayEnzymeReaction/3302
pathway order: PathwayEnzymeReaction/3313
pathway order: PathwayEnzymeReaction/1207
pathway order: PathwayEnzymeReaction/3303
pathway order: PathwayEnzymeReaction/1206
pathway order: PathwayEnzymeReaction/3304
pathway order: PathwayEnzymeReaction/1106
pathway order: PathwayEnzymeReaction/1117
pathway order: PathwayEnzymeReaction/3305
pathway component: ReactionCatalysis576
pathway component: ReactionCatalysis574
pathway component: 2.3.1.51
pathway component: 1.1.5.3
pathway component: 3.1.3.4
pathway component: Reaction1175
pathway component: 1.1.1.21
pathway component: 3.1.1.3
pathway component: Reaction1151
pathway component: Fatty Acid Metabolism
pathway component: ReactionCatalysis1329
pathway component: 2.3.1.15
pathway component: ReactionCatalysis526
pathway component: 3.1.1.34
pathway component: ReactionCatalysis843
pathway component: ReactionCatalysis844
pathway component: ReactionCatalysis883
pathway component: 2.7.1.31
pathway component: ReactionCatalysis917
pathway component: Glycolysis
pathway component: 1.1.1.8
pathway component: ReactionCatalysis836
pathway component: ReactionCatalysis933
pathway component: 1.2.1.5
pathway component: ReactionCatalysis934
pathway component: ReactionCatalysis876
pathway component: ReactionCatalysis855
pathway component: ReactionCatalysis877
xref: Reference/SMPDB SMP0000529
xref: Reference/PathWhiz PW000505
organism: Homo sapiens

Aldose reductase
type: ProteinReference
xref: Reference/UniProt P15121
organism: Homo sapiens

Compound/PW C000081 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glycerol 3-phosphate
stoichiometric coefficient: 1.0

Compound/PW C007130 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: MG(0:0/16:0/0:0)
stoichiometric coefficient: 1.0

Reference/UniProt O14494
type: UnificationXref
id: O14494
db: UniProt

Glycerate kinase
type: Protein
cellular location: Cytoplasm
entity reference: Glycerate kinase

Reference/KEGG Compound C00530
type: UnificationXref
id: C00530
db: KEGG Compound

DG(16:0/16:0/0:0)
type: SmallMolecule
cellular location: Cytosol
entity reference: DG(16:0/16:0/0:0)

Lipid phosphate phosphohydrolase 1
type: Protein
cellular location: Endoplasmic Reticulum Membrane
entity reference: Lipid phosphate phosphohydrolase 1

Compound/PW C001099 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/UniProt P43304
type: UnificationXref
id: P43304
db: UniProt

3.1.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C003149 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000145 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C002417 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: DG(16:0/16:0/0:0)
right: Palmitic acid
spontaneous: false
EC number: 3.1.1.3
left: TG(16:0/16:0/16:0)
left: Water
name: TG(16:0/16:0/16:0) + Water → DG(16:0/16:0/0:0) + Palmitic acid
conversion direction: LEFT_TO_RIGHT

Glycerol
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Glycerol

TG(16:0/16:0/16:0)
type: SmallMolecule
cellular location: Extracellular Space
entity reference: TG(16:0/16:0/16:0)

Reference/PubChem-compound 15667
type: UnificationXref
id: 15667
db: PubChem-compound

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

ChemicalStructure/PW C003904
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCCCCCC(=O)OCC(O)COP(O)(O)=O

Reference/CAS 106-51-4
type: UnificationXref
id: 106-51-4
db: CAS

Reference/HMDB HMDB0011533
type: UnificationXref
id: HMDB0011533
db: HMDB

Compound/PW C001099 Mitochondrial Outer Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Glyceraldehyde
type: SmallMolecule
cellular location: Cytosol
entity reference: Glyceraldehyde

Compound/PW C000828 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glyceraldehyde
stoichiometric coefficient: 1.0

3.1.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003149 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007130 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000145 Extracellular Space/Stoichiometry/1.0
right: MG(0:0/16:0/0:0)
right: Palmitic acid
spontaneous: false
EC number: 3.1.1.3
left: DG(16:0/16:0/0:0)
left: Water
name: DG(16:0/16:0/0:0) + Water → MG(0:0/16:0/0:0) + Palmitic acid
conversion direction: LEFT_TO_RIGHT

3.1.1.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007130 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000085 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000145 Extracellular Space/Stoichiometry/1.0
right: Glycerol
right: Palmitic acid
spontaneous: false
EC number: 3.1.1.3
left: MG(0:0/16:0/0:0)
left: Water
name: MG(0:0/16:0/0:0) + Water → Glycerol + Palmitic acid
conversion direction: LEFT_TO_RIGHT

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS