Compound/PW C009230 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Irinotecan
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/HMDB HMDB0061360
type: UnificationXref
id: HMDB0061360
db: HMDB

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Compound/Generic71 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carboxylate
stoichiometric coefficient: 1.0

Reference/UniProt P13667
type: UnificationXref
id: P13667
db: UniProt

Reference/ChemSpider 9931059
type: UnificationXref
id: 9931059
db: ChemSpider

Reference/UniProt O00748
type: UnificationXref
id: O00748
db: UniProt

Compound/PW C009230 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Irinotecan
stoichiometric coefficient: 1.0

Stromal cell-derived factor 2-like protein 1
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Stromal cell-derived factor 2-like protein 1

NPC
type: SmallMolecule
cellular location: Cytoplasm
entity reference: NPC

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Carboxylate
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Carboxylate

Transport239
type: Transport
participant stoichiometry: Compound/PW C009230 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009230 Extracellular Space/Stoichiometry/1.0
right: Irinotecan
spontaneous: false
left: Irinotecan
name: Irinotecan (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Liver, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

ReactionCoupledTransportCatalysis58
type: Catalysis
controller: Multidrug resistance protein 1
controlled: 3.6.3.44
control type: ACTIVATION

Transport238
type: Transport
participant stoichiometry: Compound/PW C040681 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040681 Extracellular Space/Stoichiometry/1.0
right: SN-38 Glucuronide
spontaneous: false
left: SN-38 Glucuronide
name: SN-38 Glucuronide (→) Transport: Homo sapiens, Liver, Cell, Cytoplasm to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Protein/5746 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Endoplasmic reticulum resident protein 29
stoichiometric coefficient: 1.0

ReactionCatalysis2099
type: Catalysis
controller: Cytochrome P450 3A4
controlled: Reaction2238
control type: ACTIVATION

ReactionCatalysis2098
type: Catalysis
controller: Cytochrome P450 3A4
controlled: Reaction2237
control type: ACTIVATION

ReactionCoupledTransportCatalysis59
type: Catalysis
controller: Canalicular multispecific organic anion transporter 1
controlled: 3.6.3.44
control type: ACTIVATION

Transport235
type: Transport
participant stoichiometry: Compound/PW C040474 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040474 Extracellular Space/Stoichiometry/1.0
right: SN-38
spontaneous: false
left: SN-38
name: SN-38 (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Liver, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Transport237
type: Transport
participant stoichiometry: Compound/PW C040474 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040474 Extracellular Space/Stoichiometry/1.0
right: SN-38
spontaneous: false
left: SN-38
name: SN-38 (→) Transport: Homo sapiens, Liver, Cell, Cytoplasm to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Transport236
type: Transport
participant stoichiometry: Compound/PW C009230 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009230 Extracellular Space/Stoichiometry/1.0
right: Irinotecan
spontaneous: false
left: Irinotecan
name: Irinotecan (→) Transport: Homo sapiens, Liver, Cell, Cytoplasm to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Compound/PW C040680 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: NPC
stoichiometric coefficient: 1.0

SN-38
type: SmallMolecule
cellular location: Cytoplasm
entity reference: SN-38

ChemicalStructure/PW C040474
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q92887
type: UnificationXref
id: Q92887
db: UniProt

Reference/CAS 2616-64-0
type: UnificationXref
id: 2616-64-0
db: CAS

Cytochrome P450 3A4
type: ProteinReference
xref: Reference/UniProt P08684
organism: BiologicalState31

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Cytochrome P450 3A5
type: ProteinReference
xref: Reference/UniProt P20815
organism: BiologicalState31

Compound/PW C040474 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: SN-38
stoichiometric coefficient: 1.0

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Irinotecan
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Irinotecan

ReactionCatalysis1456
type: Catalysis
controller: Liver carboxylesterase 1
controlled: Reaction1729
control type: ACTIVATION

ReactionCoupledTransportCatalysis61
type: Catalysis
controller: Canalicular multispecific organic anion transporter 1
controlled: 3.6.3.44
control type: ACTIVATION

Reference/CAS 97682-44-5
type: UnificationXref
id: 97682-44-5
db: CAS

ReactionCoupledTransportCatalysis60
type: Catalysis
controller: Multidrug resistance protein 1
controlled: 3.6.3.44
control type: ACTIVATION

ReactionCatalysis1455
type: Catalysis
controller: Cholinesterase
controlled: Reaction1729
control type: ACTIVATION

Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Compound/Generic71 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carboxylate
stoichiometric coefficient: 1.0

SN-38 Glucuronide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: SN-38 Glucuronide

ReactionCoupledTransportCatalysis63
type: Catalysis
controller: Canalicular multispecific organic anion transporter 1
controlled: ReactionCoupledTransport53
control type: ACTIVATION

ReactionCatalysis1457
type: Catalysis
controller: Cocaine esterase
controlled: Reaction1729
control type: ACTIVATION

ReactionCoupledTransportCatalysis62
type: Catalysis
controller: ATP-binding cassette sub-family G member 2
controlled: 3.6.3.44
control type: ACTIVATION

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Compound/PW C009230 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Irinotecan
stoichiometric coefficient: 1.0

Irinotecan Metabolism Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/3170
pathway order: PathwayEnzymeReaction/3171
pathway order: PathwayEnzymeReaction/3172
pathway order: PathwayEnzymeReaction/3158
pathway order: PathwayTransport/3135
pathway order: PathwayEnzymeReaction/3173
pathway order: PathwayTransport/3136
pathway order: PathwayEnzymeReaction/3174
pathway order: PathwayEnzymeReaction/3175
pathway order: PathwayTransport/3134
pathway order: PathwayTransport/3117
pathway order: PathwayTransport/3139
pathway order: PathwayTransport/3115
pathway order: PathwayTransport/3137
pathway order: PathwayTransport/3116
pathway order: PathwayTransport/3138
pathway order: PathwayEnzymeReaction/3160
pathway order: PathwayEnzymeReaction/3161
pathway order: PathwayEnzymeReaction/3122
pathway order: PathwayEnzymeReaction/3166
pathway order: PathwayEnzymeReaction/3123
pathway order: PathwayEnzymeReaction/3167
pathway order: PathwayEnzymeReaction/3168
pathway order: PathwayEnzymeReaction/3169
pathway order: PathwaySubPathway/549
pathway order: PathwayEnzymeReaction/3162
pathway order: PathwayEnzymeReaction/3163
pathway order: PathwayEnzymeReaction/3164
pathway order: PathwayEnzymeReaction/3121
pathway order: PathwayEnzymeReaction/3165
pathway order: PathwayEnzymeReaction/3159
pathway component: SubPathwayControl549
pathway component: 2.4.1.17
pathway component: Transport239
pathway component: ReactionCoupledTransportCatalysis58
pathway component: Transport238
pathway component: ReactionCatalysis2099
pathway component: ReactionCatalysis2098
pathway component: ReactionCoupledTransportCatalysis59
pathway component: Transport235
pathway component: Transport237
pathway component: Transport236
pathway component: TransportCatalysis197
pathway component: TransportCatalysis196
pathway component: Reaction1729
pathway component: TransportCatalysis195
pathway component: TransportCatalysis194
pathway component: TransportCatalysis193
pathway component: TransportCatalysis192
pathway component: TransportCatalysis191
pathway component: TransportCatalysis190
pathway component: 3.6.3.44
pathway component: ReactionCatalysis1456
pathway component: ReactionCoupledTransportCatalysis61
pathway component: ReactionCoupledTransportCatalysis60
pathway component: ReactionCatalysis2104
pathway component: ReactionCatalysis1455
pathway component: ReactionCoupledTransportCatalysis63
pathway component: ReactionCatalysis1457
pathway component: ReactionCoupledTransportCatalysis62
pathway component: ReactionCoupledTransport53
pathway component: ReactionCatalysis2108
pathway component: Reaction2238
pathway component: Reaction2239
pathway component: ReactionCatalysis2101
pathway component: ReactionCatalysis2100
pathway component: Reaction2237
pathway component: TransportCatalysis189
pathway component: ReactionCatalysis2103
pathway component: ReactionCatalysis2102
xref: Reference/PathWhiz PW000576
xref: Reference/SMPDB SMP0000600
organism: Homo sapiens

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Protein/5741 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: HYOU1 protein
stoichiometric coefficient: 1.0

Cholinesterase
type: Complex
component stoichiometry: Protein/499 Extracellular Space/Stoichiometry/4.0
cellular location: Extracellular Space
component: Cholinesterase

Reference/CELL TYPE ONTOLOGY CL 0000182
type: UnificationXref
id: CL:0000182
db: CELL TYPE ONTOLOGY

Protein/5740 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: 78 kDa glucose-regulated protein
stoichiometric coefficient: 1.0

Reference/BRENDA TISSUE ONTOLOGY BTO 0000759
type: UnificationXref
id: BTO:0000759
db: BRENDA TISSUE ONTOLOGY

Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/UniProt P11387
type: UnificationXref
id: P11387
db: UniProt

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/ChEBI CHEBI 17200
type: UnificationXref
id: CHEBI:17200
db: ChEBI

DnaJ homolog subfamily B member 11
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: DnaJ homolog subfamily B member 11

2.4.1.17
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040681 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000746 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040474 Endoplasmic Reticulum/Stoichiometry/1.0
right: SN-38 Glucuronide
right: Uridine 5'-diphosphate
spontaneous: false
EC number: 2.4.1.17
left: SN-38
left: Uridine diphosphate glucuronic acid
name: SN-38 + Uridine diphosphate glucuronic acid → SN-38 Glucuronide + Uridine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

SN-38
type: SmallMolecule
cellular location: Extracellular Space
entity reference: SN-38

Reference/ChemSpider 8253122
type: UnificationXref
id: 8253122
db: ChemSpider

Reference/UniProt P11021
type: UnificationXref
id: P11021
db: UniProt

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Uridine 5'-diphosphate

Protein/465 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-glucuronosyltransferase 1-1
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phosphate

SN-38 inhibition of DNA topoisomerase 1
type: Pathway
name: InhibitorySubPathway

Reference/BioCyc UDP-GLUCURONATE
type: UnificationXref
id: UDP-GLUCURONATE
db: BioCyc

Reference/CAS 86639-52-3
type: UnificationXref
id: 86639-52-3
db: CAS

Reference/PubChem-compound 6031
type: UnificationXref
id: 6031
db: PubChem-compound

Reference/UniProt Q6IN67
type: UnificationXref
id: Q6IN67
db: UniProt

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Protein/479 Cytoplasm/Stoichiometry/3.0
type: Stoichiometry
physical entity: Liver carboxylesterase 1
stoichiometric coefficient: 3.0

ChemicalStructure/PW C000201
type: ChemicalStructure
structure format: SMILES

ATP-binding cassette sub-family G member 2
type: Protein
cellular location: Cell Membrane
entity reference: ATP-binding cassette sub-family G member 2

Reaction2238
type: BiochemicalReaction
participant stoichiometry: Compound/PW C009230 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040680 Cytoplasm/Stoichiometry/1.0
right: NPC
spontaneous: false
left: Irinotecan
name: Irinotecan → NPC
conversion direction: LEFT_TO_RIGHT

Reaction2239
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040680 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040474 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/Generic71 Endoplasmic Reticulum/Stoichiometry/1.0
right: SN-38
right: Carboxylate
spontaneous: false
left: Water
left: NPC
name: NPC + Water → Carboxylate + SN-38
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0060499
type: UnificationXref
id: HMDB0060499
db: HMDB

Reference/UniProt Q9HCN8
type: UnificationXref
id: Q9HCN8
db: UniProt

Reaction2237
type: BiochemicalReaction
participant stoichiometry: Compound/PW C009230 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040679 Cytoplasm/Stoichiometry/1.0
right: APC
spontaneous: false
left: Irinotecan
name: Irinotecan → APC
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 161315
type: UnificationXref
id: CHEBI:161315
db: ChEBI

Compound/PW C040681 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: SN-38 Glucuronide
stoichiometric coefficient: 1.0

Uridine diphosphate glucuronic acid
type: SmallMoleculeReference
xref: Reference/BioCyc UDP-GLUCURONATE
xref: Reference/CAS 2616-64-0
xref: Reference/PubChem-compound 17473
xref: Reference/HMDB HMDB0000935
xref: Reference/ChEBI CHEBI 17200
xref: Reference/ChemSpider 16522
xref: Reference/KEGG Compound C00167
chemical formula: C15H22N2O18P2
molecular weight: 580.0343
structure: ChemicalStructure/PW C000746

Reference/SMPDB SMP0000600
type: UnificationXref
id: SMP0000600
db: SMPDB

UDP-glucuronosyltransferase 1-10
type: ProteinReference
xref: Reference/UniProt Q9HAW8
organism: Homo sapiens

UDP-glucuronosyltransferase 1-9
type: ProteinReference
xref: Reference/UniProt O60656
organism: Homo sapiens

UDP-glucuronosyltransferase 1-1
type: ProteinReference
xref: Reference/UniProt P22309
organism: Homo sapiens

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/UniProt Q9HAW8
type: UnificationXref
id: Q9HAW8
db: UniProt

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Protein/5742 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein disulfide-isomerase A2
stoichiometric coefficient: 1.0

Reference/UniProt Q96GW1
type: UnificationXref
id: Q96GW1
db: UniProt

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reaction1729
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/Generic71 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009230 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040474 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009230 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/Generic71 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040474 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009230 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040474 Endoplasmic Reticulum/Stoichiometry/1.0
participant stoichiometry: Compound/Generic71 Endoplasmic Reticulum/Stoichiometry/1.0
right: SN-38
right: Carboxylate
spontaneous: false
left: Irinotecan
left: Water
name: Irinotecan + Water → Carboxylate + SN-38
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C040679
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q13087
type: UnificationXref
id: Q13087
db: UniProt

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/UniProt Q9UBS4
type: UnificationXref
id: Q9UBS4
db: UniProt

Liver carboxylesterase 1
type: ProteinReference
xref: Reference/UniProt P23141
organism: Homo sapiens

Compound/PW C040681 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: SN-38 Glucuronide
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Liver
type: TissueVocabulary
xref: Reference/BRENDA TISSUE ONTOLOGY BTO 0000759

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Compound/Generic71 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carboxylate
stoichiometric coefficient: 1.0

Reference/PubChem-compound 17473
type: UnificationXref
id: 17473
db: PubChem-compound

Reference/ChEBI CHEBI 105985
type: UnificationXref
id: CHEBI:105985
db: ChEBI

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

HSP90B1 protein
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: HSP90B1 protein

Reference/HMDB HMDB0060510
type: UnificationXref
id: HMDB0060510
db: HMDB

Reference/KEGG Compound C11376
type: UnificationXref
id: C11376
db: KEGG Compound

ChemicalStructure/PW C040681
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040680
type: ChemicalStructure
structure format: SMILES

SN-38
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: SN-38

DnaJ homolog subfamily B member 11
type: ProteinReference
xref: Reference/UniProt Q9UBS4
organism: Homo sapiens

Liver carboxylesterase 1
type: Complex
component stoichiometry: Protein/479 Cytoplasm/Stoichiometry/3.0
cellular location: Cytoplasm
component: Liver carboxylesterase 1

HSP90B1 protein
type: ProteinReference
xref: Reference/UniProt Q96GW1
organism: Homo sapiens

ATP-binding cassette sub-family G member 2
type: Protein
entity reference: ATP-binding cassette sub-family G member 2

Compound/PW C040474 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: SN-38
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00015
type: UnificationXref
id: C00015
db: KEGG Compound

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Solute carrier organic anion transporter family member 1B1
type: Protein
entity reference: Solute carrier organic anion transporter family member 1B1

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

BiologicalState53
type: BioSource
cell type: Hepatocyte
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver, Hepatocyte
tissue: Liver

Cocaine esterase
type: ProteinReference
xref: Reference/UniProt O00748
organism: Homo sapiens

Hepatocyte
type: CellVocabulary
xref: Reference/CELL TYPE ONTOLOGY CL 0000182

Irinotecan
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Irinotecan

Reference/PubChem-compound 104842
type: UnificationXref
id: 104842
db: PubChem-compound

Stromal cell-derived factor 2-like protein 1
type: ProteinReference
xref: Reference/UniProt Q9HCN8
organism: Homo sapiens

Endoplasmic reticulum resident protein 29
type: ProteinReference
xref: Reference/UniProt P30040
organism: Homo sapiens

Protein disulfide-isomerase A4
type: ProteinReference
xref: Reference/UniProt P13667
organism: Homo sapiens

Protein disulfide-isomerase A6
type: ProteinReference
xref: Reference/UniProt Q15084
organism: Homo sapiens

Peptidyl-prolyl cis-trans isomerase B
type: ProteinReference
xref: Reference/UniProt P23284
organism: Homo sapiens

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

HYOU1 protein
type: ProteinReference
xref: Reference/UniProt Q6IN67
organism: Homo sapiens

Protein disulfide-isomerase A2
type: ProteinReference
xref: Reference/UniProt Q13087
organism: Homo sapiens

78 kDa glucose-regulated protein
type: ProteinReference
xref: Reference/UniProt P11021
organism: Homo sapiens

Reference/UniProt P08183
type: UnificationXref
id: P08183
db: UniProt

UDP-glucuronosyltransferase 1-9
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: UDP-glucuronosyltransferase 1-9

Reference/ChemSpider 94634
type: UnificationXref
id: 94634
db: ChemSpider

Cholinesterase
type: ProteinReference
xref: Reference/UniProt P06276
organism: Homo sapiens

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Protein disulfide-isomerase A4
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Protein disulfide-isomerase A4

Reference/PubChem-compound 60838
type: UnificationXref
id: 60838
db: PubChem-compound

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Compound/PW C040474 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: SN-38
stoichiometric coefficient: 1.0

Reference/PubChem-compound 10077584
type: UnificationXref
id: 10077584
db: PubChem-compound

Peptidyl-prolyl cis-trans isomerase B
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Peptidyl-prolyl cis-trans isomerase B

DNA topoisomerase 1
type: Protein
cellular location: Nucleus
entity reference: DNA topoisomerase 1
name: SubPathwayInhibition

Reference/KEGG Compound C11173
type: UnificationXref
id: C11173
db: KEGG Compound

SN-38
type: SmallMolecule
entity reference: SN-38
name: SubPathwayInhibitor

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005783

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Endoplasmic reticulum resident protein 29
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Endoplasmic reticulum resident protein 29

DNA topoisomerase 1
type: ProteinReference
xref: Reference/UniProt P11387
organism: Homo sapiens

SubPathwayControl549
type: Interaction
name: SubPathway549Control
name: InhibitorySubPathwayControl
participant: SN-38 inhibition of DNA topoisomerase 1
participant: SN-38
participant: DNA topoisomerase 1

Multidrug resistance-associated protein 1
type: Protein
entity reference: Multidrug resistance-associated protein 1

Reference/BioCyc UDP
type: UnificationXref
id: UDP
db: BioCyc

Carboxylate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 29067

Reference/UniProt O60656
type: UnificationXref
id: O60656
db: UniProt

Compound/PW C040681 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: SN-38 Glucuronide
stoichiometric coefficient: 1.0

BiologicalState31
type: BioSource
xref: Reference/TAXONOMY 9606
name: Homo sapiens, Liver
tissue: Liver

Reference/ChemSpider 54825
type: UnificationXref
id: 54825
db: ChemSpider

Adenosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine triphosphate

Cocaine esterase
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Cocaine esterase

Reference/UniProt P30040
type: UnificationXref
id: P30040
db: UniProt

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Protein/5738 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: DnaJ homolog subfamily B member 11
stoichiometric coefficient: 1.0

Reference/UniProt P22309
type: UnificationXref
id: P22309
db: UniProt

Liver carboxylesterase 1
type: Complex
component stoichiometry: Protein/479 Extracellular Space/Stoichiometry/3.0
cellular location: Extracellular Space
component: Liver carboxylesterase 1

Reference/PathWhiz PW000576
type: UnificationXref
id: PW000576
db: PathWhiz

Canalicular multispecific organic anion transporter 1
type: Protein
entity reference: Canalicular multispecific organic anion transporter 1

Reference/PubChem-compound 443154
type: UnificationXref
id: 443154
db: PubChem-compound

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

Reference/HMDB HMDB0000935
type: UnificationXref
id: HMDB0000935
db: HMDB

Reference/KEGG Compound C00167
type: UnificationXref
id: C00167
db: KEGG Compound

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/UniProt Q9Y6L6
type: UnificationXref
id: Q9Y6L6
db: UniProt

Multidrug resistance protein 1
type: Protein
cellular location: Cell Membrane
entity reference: Multidrug resistance protein 1

Compound/PW C000201 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Water

Uridine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17659
xref: Reference/PubChem-compound 6031
xref: Reference/CAS 58-98-0
xref: Reference/HMDB HMDB0000295
xref: Reference/KEGG Compound C00015
xref: Reference/ChemSpider 5809
xref: Reference/BioCyc UDP
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C000201

UDP-glucuronosyltransferase 1-1
type: Complex
component stoichiometry: Protein/465 Endoplasmic Reticulum/Stoichiometry/1.0
component stoichiometry: Protein/5740 Endoplasmic Reticulum/Stoichiometry/1.0
component stoichiometry: Protein/5744 Endoplasmic Reticulum/Stoichiometry/1.0
component stoichiometry: Protein/5745 Endoplasmic Reticulum/Stoichiometry/1.0
component stoichiometry: Protein/5743 Endoplasmic Reticulum/Stoichiometry/1.0
component stoichiometry: Protein/5746 Endoplasmic Reticulum/Stoichiometry/1.0
component stoichiometry: Protein/5742 Endoplasmic Reticulum/Stoichiometry/1.0
component stoichiometry: Protein/5741 Endoplasmic Reticulum/Stoichiometry/1.0
component stoichiometry: Protein/4776 Endoplasmic Reticulum/Stoichiometry/1.0
component stoichiometry: Protein/5739 Endoplasmic Reticulum/Stoichiometry/1.0
component stoichiometry: Protein/5738 Endoplasmic Reticulum/Stoichiometry/1.0
cellular location: Endoplasmic Reticulum
component: UDP-glucuronosyltransferase 1-1
component: 78 kDa glucose-regulated protein
component: Protein disulfide-isomerase A4
component: Protein disulfide-isomerase A6
component: Peptidyl-prolyl cis-trans isomerase B
component: Stromal cell-derived factor 2-like protein 1
component: Endoplasmic reticulum resident protein 29
component: HSP90B1 protein
component: DnaJ homolog subfamily B member 11
component: Protein disulfide-isomerase A2
component: HYOU1 protein

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Compound/PW C040474 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: SN-38
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Cocaine esterase
type: Protein
cellular location: Cytoplasm
entity reference: Cocaine esterase

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Multidrug resistance protein 1
type: Protein
entity reference: Multidrug resistance protein 1

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Carboxylate
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Carboxylate

Protein/479 Extracellular Space/Stoichiometry/3.0
type: Stoichiometry
physical entity: Liver carboxylesterase 1
stoichiometric coefficient: 3.0

UDP-glucuronosyltransferase 1-10
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: UDP-glucuronosyltransferase 1-10

Solute carrier organic anion transporter family member 1B1
type: ProteinReference
xref: Reference/UniProt Q9Y6L6

Liver carboxylesterase 1
type: Complex
component stoichiometry: Protein/479 Endoplasmic Reticulum/Stoichiometry/3.0
cellular location: Endoplasmic Reticulum
component: Liver carboxylesterase 1

SN-38 Glucuronide
type: SmallMolecule
cellular location: Extracellular Space
entity reference: SN-38 Glucuronide

Reference/GENE ONTOLOGY GO 0005783
type: UnificationXref
id: GO:0005783
db: GENE ONTOLOGY

Protein/4776 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Peptidyl-prolyl cis-trans isomerase B
stoichiometric coefficient: 1.0

Water
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Water

Compound/PW C040679 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 1.0

Reference/ChemSpider 16522
type: UnificationXref
id: 16522
db: ChemSpider

TransportCatalysis197
type: Catalysis
controller: Multidrug resistance protein 1
controlled: Transport239
control type: ACTIVATION

SN-38
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 161315
xref: Reference/ChemSpider 94634
xref: Reference/CAS 86639-52-3
xref: Reference/KEGG Compound C11173
xref: Reference/PubChem-compound 104842
xref: Reference/HMDB HMDB0060510
chemical formula: C22H20N2O5
molecular weight: 392.1372
structure: ChemicalStructure/PW C040474

Irinotecan
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Irinotecan

TransportCatalysis196
type: Catalysis
controller: Canalicular multispecific organic anion transporter 1
controlled: Transport238
control type: ACTIVATION

78 kDa glucose-regulated protein
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: 78 kDa glucose-regulated protein

Reference/HMDB HMDB0060661
type: UnificationXref
id: HMDB0060661
db: HMDB

TransportCatalysis195
type: Catalysis
controller: ATP-binding cassette sub-family G member 2
controlled: Transport237
control type: ACTIVATION

TransportCatalysis194
type: Catalysis
controller: Canalicular multispecific organic anion transporter 1
controlled: Transport237
control type: ACTIVATION

ATP-binding cassette sub-family G member 2
type: ProteinReference
xref: Reference/UniProt Q9UNQ0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Protein disulfide-isomerase A6
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Protein disulfide-isomerase A6

TransportCatalysis193
type: Catalysis
controller: Multidrug resistance protein 1
controlled: Transport237
control type: ACTIVATION

TransportCatalysis192
type: Catalysis
controller: Canalicular multispecific organic anion transporter 1
controlled: Transport236
control type: ACTIVATION

TransportCatalysis191
type: Catalysis
controller: Multidrug resistance protein 1
controlled: Transport236
control type: ACTIVATION

TransportCatalysis190
type: Catalysis
controller: Multidrug resistance-associated protein 1
controlled: Transport235
control type: ACTIVATION

Compound/PW C009230 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Irinotecan
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

3.6.3.44
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040474 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: SN-38
right: Phosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 3.6.3.44
left: SN-38
left: Water
left: Adenosine triphosphate
name: Adenosine triphosphate + SN-38 + Water → Adenosine diphosphate + Phosphate + SN-38
conversion direction: LEFT_TO_RIGHT

SN-38
type: SmallMolecule
cellular location: Cell Membrane
entity reference: SN-38

3.6.3.44
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C009230 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: Adenosine diphosphate
right: Irinotecan
spontaneous: false
EC number: 3.6.3.44
left: Irinotecan
left: Water
left: Adenosine triphosphate
name: Adenosine triphosphate + Irinotecan + Water ? Adenosine diphosphate + Irinotecan + Phosphate

ReactionCoupledTransport53
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C040681 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: Adenosine diphosphate
right: SN-38 Glucuronide
spontaneous: false
left: SN-38 Glucuronide
left: Water
left: Adenosine triphosphate
name: Adenosine triphosphate + SN-38 Glucuronide + Water → Adenosine diphosphate + Phosphate + SN-38 Glucuronide
conversion direction: LEFT_TO_RIGHT

Irinotecan
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Irinotecan

Cytochrome P450 3A5
type: Protein
cellular location: Cytoplasm
entity reference: Cytochrome P450 3A5

Irinotecan
type: SmallMoleculeReference
xref: Reference/CAS 97682-44-5
xref: Reference/HMDB HMDB0014900
xref: Reference/PubChem-compound 60838
xref: Reference/ChEBI CHEBI 105985
xref: Reference/ChemSpider 54825
xref: Reference/KEGG Compound C16641
chemical formula: C33H38N4O6
molecular weight: 586.2791
structure: ChemicalStructure/PW C009230

Reference/UniProt P20815
type: UnificationXref
id: P20815
db: UniProt

Protein/5743 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein disulfide-isomerase A4
stoichiometric coefficient: 1.0

Reference/KEGG Compound C16641
type: UnificationXref
id: C16641
db: KEGG Compound

Protein disulfide-isomerase A2
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Protein disulfide-isomerase A2

TransportCatalysis189
type: Catalysis
controller: Solute carrier organic anion transporter family member 1B1
controlled: Transport235
control type: ACTIVATION

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Canalicular multispecific organic anion transporter 1
type: Protein
cellular location: Cell Membrane
entity reference: Canalicular multispecific organic anion transporter 1

Compound/PW C000746 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate glucuronic acid
stoichiometric coefficient: 1.0

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/CAS 58-98-0
type: UnificationXref
id: 58-98-0
db: CAS

Uridine diphosphate glucuronic acid
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: Uridine diphosphate glucuronic acid

UDP-glucuronosyltransferase 1-1
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: UDP-glucuronosyltransferase 1-1

Compound/PW C040680 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: NPC
stoichiometric coefficient: 1.0

Protein/499 Extracellular Space/Stoichiometry/4.0
type: Stoichiometry
physical entity: Cholinesterase
stoichiometric coefficient: 4.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/HMDB HMDB0000295
type: UnificationXref
id: HMDB0000295
db: HMDB

Reference/PubChem-compound 11756356
type: UnificationXref
id: 11756356
db: PubChem-compound

Reference/ChemSpider 5809
type: UnificationXref
id: 5809
db: ChemSpider

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Multidrug resistance-associated protein 1
type: ProteinReference
xref: Reference/UniProt P33527

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/HMDB HMDB0014900
type: UnificationXref
id: HMDB0014900
db: HMDB

Reference/UniProt P08684
type: UnificationXref
id: P08684
db: UniProt

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Liver carboxylesterase 1
type: Protein
cellular location: Extracellular Space
entity reference: Liver carboxylesterase 1

Reference/UniProt P23141
type: UnificationXref
id: P23141
db: UniProt

ReactionCatalysis2104
type: Catalysis
controller: UDP-glucuronosyltransferase 1-10
controlled: 2.4.1.17
control type: ACTIVATION

SN-38 Glucuronide
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: SN-38 Glucuronide

ReactionCatalysis2108
type: Catalysis
controller: UDP-glucuronosyltransferase 1-9
controlled: 2.4.1.17
control type: ACTIVATION

Liver carboxylesterase 1
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: Liver carboxylesterase 1

Protein/5745 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Stromal cell-derived factor 2-like protein 1
stoichiometric coefficient: 1.0

Reference/KEGG Compound C16542
type: UnificationXref
id: C16542
db: KEGG Compound

ReactionCatalysis2101
type: Catalysis
controller: Liver carboxylesterase 1
controlled: Reaction2239
control type: ACTIVATION

Reference/KEGG Compound C16543
type: UnificationXref
id: C16543
db: KEGG Compound

ReactionCatalysis2100
type: Catalysis
controller: Cytochrome P450 3A5
controlled: Reaction2238
control type: ACTIVATION

Carboxylate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Carboxylate

ChemicalStructure/PW C009230
type: ChemicalStructure
structure format: SMILES

Protein/5739 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: HSP90B1 protein
stoichiometric coefficient: 1.0

ReactionCatalysis2103
type: Catalysis
controller: UDP-glucuronosyltransferase 1-1
controlled: 2.4.1.17
control type: ACTIVATION

NPC
type: SmallMolecule
cellular location: Endoplasmic Reticulum
entity reference: NPC

ReactionCatalysis2102
type: Catalysis
controller: Cocaine esterase
controlled: Reaction2239
control type: ACTIVATION

Reference/ChemSpider 391426
type: UnificationXref
id: 391426
db: ChemSpider

Reference/UniProt P06276
type: UnificationXref
id: P06276
db: UniProt

Compound/PW C040681 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: SN-38 Glucuronide
stoichiometric coefficient: 1.0

Canalicular multispecific organic anion transporter 1
type: ProteinReference
xref: Reference/UniProt Q92887

Compound/PW C001420 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000746
type: ChemicalStructure
structure format: SMILES

Liver carboxylesterase 1
type: Protein
cellular location: Cytoplasm
entity reference: Liver carboxylesterase 1

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Protein/5744 Endoplasmic Reticulum/Stoichiometry/1.0
type: Stoichiometry
physical entity: Protein disulfide-isomerase A6
stoichiometric coefficient: 1.0

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

Cytochrome P450 3A4
type: Protein
cellular location: Cytoplasm
entity reference: Cytochrome P450 3A4

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/UniProt Q9UNQ0
type: UnificationXref
id: Q9UNQ0
db: UniProt

Protein/479 Endoplasmic Reticulum/Stoichiometry/3.0
type: Stoichiometry
physical entity: Liver carboxylesterase 1
stoichiometric coefficient: 3.0

Reference/ChEBI CHEBI 17659
type: UnificationXref
id: CHEBI:17659
db: ChEBI

Multidrug resistance protein 1
type: ProteinReference
xref: Reference/UniProt P08183

SN-38 Glucuronide
type: SmallMolecule
cellular location: Cell Membrane
entity reference: SN-38 Glucuronide

APC
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0060661
xref: Reference/PubChem-compound 10077584
xref: Reference/ChemSpider 8253122
xref: Reference/KEGG Compound C16542
chemical formula: C33H38N4O8
molecular weight: 618.269
structure: ChemicalStructure/PW C040679

APC
type: SmallMolecule
cellular location: Cytoplasm
entity reference: APC

Reference/UniProt Q15084
type: UnificationXref
id: Q15084
db: UniProt

Cocaine esterase
type: Protein
cellular location: Extracellular Space
entity reference: Cocaine esterase

Reference/UniProt P33527
type: UnificationXref
id: P33527
db: UniProt

Reference/UniProt P23284
type: UnificationXref
id: P23284
db: UniProt

HYOU1 protein
type: Protein
cellular location: Endoplasmic Reticulum
entity reference: HYOU1 protein

Adenosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine diphosphate

Cholinesterase
type: Protein
cellular location: Extracellular Space
entity reference: Cholinesterase

Reference/ChEBI CHEBI 29067
type: UnificationXref
id: CHEBI:29067
db: ChEBI

NPC
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0060499
xref: Reference/ChemSpider 9931059
xref: Reference/KEGG Compound C16543
xref: Reference/PubChem-compound 11756356
chemical formula: C28H30N4O6
molecular weight: 518.21655
structure: ChemicalStructure/PW C040680

SN-38 Glucuronide
type: SmallMoleculeReference
xref: Reference/ChemSpider 391426
xref: Reference/HMDB HMDB0061360
xref: Reference/PubChem-compound 443154
xref: Reference/KEGG Compound C11376
chemical formula: C28H28N2O11
molecular weight: 568.1693
structure: ChemicalStructure/PW C040681