Reference/SMPDB SMP0000649
type: UnificationXref
id: SMP0000649
db: SMPDB

Compound/PW C009184 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lamivudine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/CAS 7722-84-1
type: UnificationXref
id: 7722-84-1
db: CAS

O-Phosphoethanolamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000224
xref: Reference/BioCyc PHOSPHORYL-ETHANOLAMINE
xref: Reference/ChemSpider 990
xref: Reference/PubChem-compound 1015
xref: Reference/KEGG Compound C00346
xref: Reference/ChEBI CHEBI 17553
xref: Reference/CAS 1071-23-4
chemical formula: C2H8NO4P
molecular weight: 141.01909
structure: ChemicalStructure/PW C000149

Reference/BioCyc PHOSPHORYL-ETHANOLAMINE
type: UnificationXref
id: PHOSPHORYL-ETHANOLAMINE
db: BioCyc

Reference/HMDB HMDB0061362
type: UnificationXref
id: HMDB0061362
db: HMDB

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/PubChem-compound 1014
type: UnificationXref
id: 1014
db: PubChem-compound

Reference/PubChem-compound 1015
type: UnificationXref
id: 1015
db: PubChem-compound

Reference/HMDB HMDB0003125
type: UnificationXref
id: HMDB0003125
db: HMDB

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ChemicalStructure/PW C001783
type: ChemicalStructure
structure format: SMILES
structure data: OO

Solute carrier family 22 member 2
type: ProteinReference
xref: Reference/UniProt O15244

2.8.2.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001783 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040661 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009184 Cytoplasm/Stoichiometry/1.0
right: Hydrogen peroxide
right: Lamivudine sulfoxide
spontaneous: false
EC number: 2.8.2.1
left: Oxygen
left: Water
left: Lamivudine
name: Lamivudine + Oxygen + Water → Hydrogen peroxide + Lamivudine sulfoxide
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0061356
type: UnificationXref
id: HMDB0061356
db: HMDB

Compound/PW C001202 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphorylcholine
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6133
type: UnificationXref
id: 6133
db: PubChem-compound

Reference/PubChem-compound 452020
type: UnificationXref
id: 452020
db: PubChem-compound

Reference/UniProt Q92887
type: UnificationXref
id: Q92887
db: UniProt

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Compound/PW C040660 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lamivudine-triphosphate
stoichiometric coefficient: 1.0

5'(3')-deoxyribonucleotidase, cytosolic type
type: Protein
cellular location: Cytoplasm
entity reference: 5'(3')-deoxyribonucleotidase, cytosolic type

Solute carrier family 22 member 3
type: ProteinReference
xref: Reference/UniProt O75751

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/UniProt O15438
type: UnificationXref
id: O15438
db: UniProt

Reference/UniProt O15439
type: UnificationXref
id: O15439
db: UniProt

Water
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Water

Lamivudine-monophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Lamivudine-monophosphate

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Adenosine diphosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Adenosine diphosphate

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Sulfotransferase 1A1
type: Protein
cellular location: Cytoplasm
entity reference: Sulfotransferase 1A1

Lamivudine-monophosphate
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Lamivudine-monophosphate

5'(3')-deoxyribonucleotidase, cytosolic type
type: Complex
component stoichiometry: Protein/6 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: 5'(3')-deoxyribonucleotidase, cytosolic type

Reference/UniProt P27707
type: UnificationXref
id: P27707
db: UniProt

UMP-CMP kinase
type: ProteinReference
xref: Reference/UniProt P30085
organism: Homo sapiens

Choline-phosphate cytidylyltransferase A
type: Protein
cellular location: Cytoplasm
entity reference: Choline-phosphate cytidylyltransferase A

Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/ChemSpider 952
type: UnificationXref
id: 952
db: ChemSpider

Lamivudine-diphosphate-ethanolamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Lamivudine-diphosphate-ethanolamine

Lamivudine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Lamivudine

Lamivudine
type: SmallMoleculeReference
xref: Reference/KEGG Compound C07065
xref: Reference/HMDB HMDB0014847
xref: Reference/PubChem-compound 60825
xref: Reference/ChEBI CHEBI 63577
xref: Reference/CAS 134678-17-4
xref: Reference/ChemSpider 54812
chemical formula: C8H11N3O3S
molecular weight: 229.05211
structure: ChemicalStructure/PW C009184

5'(3')-deoxyribonucleotidase, cytosolic type
type: ProteinReference
xref: Reference/UniProt Q8TCD5
organism: Homo sapiens

Deoxycytidine kinase
type: ProteinReference
xref: Reference/UniProt P27707
organism: Homo sapiens

Reference/HMDB HMDB0061354
type: UnificationXref
id: HMDB0061354
db: HMDB

HIV Reverse Transcriptase
type: Pathway
name: InhibitorySubPathway

Reference/HMDB HMDB0061355
type: UnificationXref
id: HMDB0061355
db: HMDB

Phosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Phosphate

Reference/PubChem-compound 6031
type: UnificationXref
id: 6031
db: PubChem-compound

Reference/ChEBI CHEBI 64482
type: UnificationXref
id: CHEBI:64482
db: ChEBI

Reference/HMDB HMDB0014847
type: UnificationXref
id: HMDB0014847
db: HMDB

Reference/ChEBI CHEBI 15713
type: UnificationXref
id: CHEBI:15713
db: ChEBI

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Reference/ChEBI CHEBI 16240
type: UnificationXref
id: CHEBI:16240
db: ChEBI

Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00346
type: UnificationXref
id: C00346
db: KEGG Compound

Reference/KEGG Compound C00588
type: UnificationXref
id: C00588
db: KEGG Compound

Reference/UniProt O75751
type: UnificationXref
id: O75751
db: UniProt

Reference/ChemSpider 398148
type: UnificationXref
id: 398148
db: ChemSpider

ChemicalStructure/PW C000201
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

ChemicalStructure/PW C009184
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC(=O)N(C=C1)[C@@H]1CS[C@H](CO)O1

TransportCatalysis165
type: Catalysis
controller: Solute carrier family 22 member 3
controlled: Transport203
control type: ACTIVATION

ChemicalStructure/PW C040664
type: ChemicalStructure
structure format: SMILES

TransportCatalysis164
type: Catalysis
controller: Solute carrier family 22 member 2
controlled: Transport203
control type: ACTIVATION

ChemicalStructure/PW C040663
type: ChemicalStructure
structure format: SMILES

TransportCatalysis163
type: Catalysis
controller: Solute carrier family 22 member 1
controlled: Transport203
control type: ACTIVATION

ChemicalStructure/PW C040662
type: ChemicalStructure
structure format: SMILES

Multidrug resistance-associated protein 1
type: Protein
cellular location: Cell Membrane
entity reference: Multidrug resistance-associated protein 1

ChemicalStructure/PW C040661
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc CPD-6641
type: UnificationXref
id: CPD-6641
db: BioCyc

Nucleoside diphosphate kinase A
type: ProteinReference
xref: Reference/UniProt P15531
organism: Homo sapiens

Compound/PW C000192 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine triphosphate
stoichiometric coefficient: 1.0

Protein/335 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Sulfotransferase 1A1
stoichiometric coefficient: 2.0

Reference/CAS 1071-23-4
type: UnificationXref
id: 1071-23-4
db: CAS

Uridine triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6133
xref: Reference/CAS 63-39-8
xref: Reference/ChemSpider 5903
xref: Reference/ChEBI CHEBI 15713
xref: Reference/KEGG Compound C00075
xref: Reference/HMDB HMDB0000285
xref: Reference/BioCyc UTP
chemical formula: C9H15N2O15P3
molecular weight: 483.96854
structure: ChemicalStructure/PW C000192

ReactionCoupledTransportCatalysis93
type: Catalysis
controller: Canalicular multispecific organic anion transporter 2
controlled: ReactionCoupledTransport75
control type: ACTIVATION

ReactionCoupledTransportCatalysis96
type: Catalysis
controller: Multidrug resistance protein 1
controlled: 3.6.3.44
control type: ACTIVATION

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Protein/7 Nucleus/Stoichiometry/2.0
type: Stoichiometry
physical entity: Deoxycytidine kinase
stoichiometric coefficient: 2.0

ReactionCoupledTransportCatalysis92
type: Catalysis
controller: Canalicular multispecific organic anion transporter 1
controlled: ReactionCoupledTransport75
control type: ACTIVATION

ReactionCoupledTransportCatalysis91
type: Catalysis
controller: Multidrug resistance-associated protein 1
controlled: ReactionCoupledTransport75
control type: ACTIVATION

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

Reference/PubChem-compound 60825
type: UnificationXref
id: 60825
db: PubChem-compound

Reference/UniProt P30085
type: UnificationXref
id: P30085
db: UniProt

Reference/UniProt P00558
type: UnificationXref
id: P00558
db: UniProt

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/HMDB HMDB0060640
type: UnificationXref
id: HMDB0060640
db: HMDB

Reference/KEGG Compound C00007
type: UnificationXref
id: C00007
db: KEGG Compound

Protein/6 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: 5'(3')-deoxyribonucleotidase, cytosolic type
stoichiometric coefficient: 2.0

TransportCatalysis171
type: Catalysis
controller: ATP-binding cassette sub-family G member 2
controlled: Transport204
control type: ACTIVATION

TransportCatalysis170
type: Catalysis
controller: Multidrug resistance-associated protein 4
controlled: Transport204
control type: ACTIVATION

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C001034 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

O-Phosphoethanolamine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: O-Phosphoethanolamine

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/HMDB HMDB0000224
type: UnificationXref
id: HMDB0000224
db: HMDB

Multidrug resistance-associated protein 4
type: Protein
entity reference: Multidrug resistance-associated protein 4

Lamivudine-monophosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Lamivudine-monophosphate

Reference/GENE ONTOLOGY GO 0005634
type: UnificationXref
id: GO:0005634
db: GENE ONTOLOGY

Compound/PW C040659 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lamivudine-monophosphate
stoichiometric coefficient: 1.0

Nucleoside diphosphate kinase A
type: Protein
cellular location: Nucleus
entity reference: Nucleoside diphosphate kinase A

TransportCatalysis169
type: Catalysis
controller: Multidrug resistance protein 1
controlled: Transport204
control type: ACTIVATION

ChemicalStructure/PW C040682
type: ChemicalStructure
structure format: SMILES
structure data: [H][C@@](CO)(COC=O)OC(C)=O

TransportCatalysis168
type: Catalysis
controller: Canalicular multispecific organic anion transporter 2
controlled: Transport204
control type: ACTIVATION

Reference/CAS 134678-17-4
type: UnificationXref
id: 134678-17-4
db: CAS

TransportCatalysis167
type: Catalysis
controller: Canalicular multispecific organic anion transporter 1
controlled: Transport204
control type: ACTIVATION

TransportCatalysis166
type: Catalysis
controller: Multidrug resistance-associated protein 1
controlled: Transport204
control type: ACTIVATION

Phosphoglycerate kinase 1
type: Protein
cellular location: Nucleus
entity reference: Phosphoglycerate kinase 1

Oxygen
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Oxygen

Compound/PW C040659 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lamivudine-monophosphate
stoichiometric coefficient: 1.0

Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine triphosphate

ATP-binding cassette sub-family G member 2
type: Protein
entity reference: ATP-binding cassette sub-family G member 2

Reference/UniProt Q8TCD5
type: UnificationXref
id: Q8TCD5
db: UniProt

Reference/KEGG Compound C00015
type: UnificationXref
id: C00015
db: KEGG Compound

Multidrug resistance-associated protein 4
type: Protein
cellular location: Cytoplasm
entity reference: Multidrug resistance-associated protein 4

Compound/PW C040663 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lamivudine-diphosphate-choline
stoichiometric coefficient: 1.0

Compound/PW C040663 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lamivudine-diphosphate-choline
stoichiometric coefficient: 1.0

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Multidrug resistance protein 1
type: Protein
cellular location: Cytoplasm
entity reference: Multidrug resistance protein 1

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Reference/HMDB HMDB0001565
type: UnificationXref
id: HMDB0001565
db: HMDB

Hydrogen peroxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Hydrogen peroxide

ChemicalStructure/PW C001202
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)CCOP(O)(O)=O

Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/ChEBI CHEBI 63577
type: UnificationXref
id: CHEBI:63577
db: ChEBI

Lamivudine-monophosphate
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Lamivudine-monophosphate

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Reference/KEGG Compound C00027
type: UnificationXref
id: C00027
db: KEGG Compound

Phosphatidylcholine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 64482

Solute carrier family 22 member 1
type: Protein
entity reference: Solute carrier family 22 member 1

Compound/PW C009184 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lamivudine
stoichiometric coefficient: 1.0

Reference/UniProt P08183
type: UnificationXref
id: P08183
db: UniProt

Uridine triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Uridine triphosphate

Lamivudine-diphosphate-choline
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Lamivudine-diphosphate-choline

Ethanolamine-phosphate cytidylyltransferase
type: Protein
cellular location: Cytoplasm
entity reference: Ethanolamine-phosphate cytidylyltransferase

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

UMP-CMP kinase
type: Protein
cellular location: Nucleus
entity reference: UMP-CMP kinase

Canalicular multispecific organic anion transporter 2
type: Protein
entity reference: Canalicular multispecific organic anion transporter 2

Reference/BioCyc PHOSPHORYL-CHOLINE
type: UnificationXref
id: PHOSPHORYL-CHOLINE
db: BioCyc

Reference/PathWhiz PW000625
type: UnificationXref
id: PW000625
db: PathWhiz

Compound/PW C040664 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lamivudine-diphosphate-ethanolamine
stoichiometric coefficient: 1.0

1,2-diacylglycerol
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061362
chemical formula: C6H10O5
molecular weight: 162.05283
structure: ChemicalStructure/PW C040682

Cholinephosphotransferase 1
type: ProteinReference
xref: Reference/UniProt Q8WUD6
organism: Homo sapiens

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

Sulfotransferase 1A1
type: Complex
component stoichiometry: Protein/335 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Sulfotransferase 1A1

SubPathwayControl668
type: Interaction
name: SubPathway668Control
name: InhibitorySubPathwayControl
participant: HIV Reverse Transcriptase

Lamivudine
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Lamivudine

Multidrug resistance-associated protein 1
type: Protein
entity reference: Multidrug resistance-associated protein 1

Reference/UniProt P49585
type: UnificationXref
id: P49585
db: UniProt

Reference/BioCyc UDP
type: UnificationXref
id: UDP
db: BioCyc

Compound/PW C000414 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis1966
type: Catalysis
controller: Deoxycytidine kinase
controlled: 2.7.1.74
control type: ACTIVATION

ReactionCatalysis1968
type: Catalysis
controller: UMP-CMP kinase
controlled: Reaction2092
control type: ACTIVATION

Reference/BioCyc HYDROGEN-PEROXIDE
type: UnificationXref
id: HYDROGEN-PEROXIDE
db: BioCyc

ReactionCatalysis1967
type: Catalysis
controller: 5'(3')-deoxyribonucleotidase, cytosolic type
controlled: 3.1.3.-
control type: ACTIVATION

Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Deoxycytidine kinase
type: Complex
component stoichiometry: Protein/7 Nucleus/Stoichiometry/2.0
cellular location: Nucleus
component: Deoxycytidine kinase

Adenosine triphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine triphosphate

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Compound/PW C000149 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: O-Phosphoethanolamine
stoichiometric coefficient: 1.0

ReactionCoupledTransportCatalysis101
type: Catalysis
controller: ATP-binding cassette sub-family G member 2
controlled: 3.6.3.44
control type: ACTIVATION

Canalicular multispecific organic anion transporter 1
type: Protein
entity reference: Canalicular multispecific organic anion transporter 1

ReactionCoupledTransportCatalysis100
type: Catalysis
controller: Multidrug resistance-associated protein 4
controlled: 3.6.3.44
control type: ACTIVATION

ReactionCatalysis1969
type: Catalysis
controller: Phosphoglycerate kinase 1
controlled: 2.7.2.3
control type: ACTIVATION

Water
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Water

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis1973
type: Catalysis
controller: Cholinephosphotransferase 1
controlled: 2.7.8.2
control type: ACTIVATION

ReactionCatalysis1972
type: Catalysis
controller: Ethanolamine-phosphate cytidylyltransferase
controlled: 2.7.7.14
control type: ACTIVATION

Reference/ChemSpider 763
type: UnificationXref
id: 763
db: ChemSpider

3.6.3.44
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C040659 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
right: Lamivudine-monophosphate
right: Adenosine diphosphate
right: Phosphate
spontaneous: false
EC number: 3.6.3.44
left: Water
left: Lamivudine-monophosphate
left: Adenosine triphosphate
name: Adenosine triphosphate + Lamivudine-monophosphate + Water → Adenosine diphosphate + Lamivudine-monophosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCoupledTransport75
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C001104 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009184 Cell Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cell Membrane/Stoichiometry/1.0
right: Phosphate
right: Adenosine diphosphate
right: Lamivudine
spontaneous: false
left: Water
left: Adenosine triphosphate
left: Lamivudine
name: Adenosine triphosphate + Lamivudine + Water → Adenosine diphosphate + Lamivudine + Phosphate
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis1976
type: Catalysis
controller: Sulfotransferase 1A1
controlled: 2.8.2.1
control type: ACTIVATION

Golgi Apparatus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005794

Reference/UniProt P50225
type: UnificationXref
id: P50225
db: UniProt

Uridine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17659
xref: Reference/PubChem-compound 6031
xref: Reference/CAS 58-98-0
xref: Reference/HMDB HMDB0000295
xref: Reference/KEGG Compound C00015
xref: Reference/ChemSpider 5809
xref: Reference/BioCyc UDP
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C000201

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Uridine 5'-diphosphate

Compound/PW C000201 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

Reference/GENE ONTOLOGY GO 0005794
type: UnificationXref
id: GO:0005794
db: GENE ONTOLOGY

ReactionCatalysis1971
type: Catalysis
controller: Choline-phosphate cytidylyltransferase A
controlled: 2.7.7.15
control type: ACTIVATION

Lamivudine-triphosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Lamivudine-triphosphate

ReactionCatalysis1970
type: Catalysis
controller: Nucleoside diphosphate kinase A
controlled: 2.7.2.3
control type: ACTIVATION

Reference/BioCyc UTP
type: UnificationXref
id: UTP
db: BioCyc

Reference/PubChem-compound 784
type: UnificationXref
id: 784
db: PubChem-compound

Cholinephosphotransferase 1
type: Protein
cellular location: Golgi Apparatus
entity reference: Cholinephosphotransferase 1

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Reference/ChemSpider 5903
type: UnificationXref
id: 5903
db: ChemSpider

Compound/PW C040662 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lamivudine-diphosphate
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: Reference/TAXONOMY 9606

Reaction2092
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040659 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040662 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Nucleus/Stoichiometry/1.0
right: Lamivudine-diphosphate
right: Adenosine diphosphate
spontaneous: false
left: Lamivudine-monophosphate
left: Adenosine triphosphate
name: Adenosine triphosphate + Lamivudine-monophosphate → Adenosine diphosphate + Lamivudine-diphosphate
conversion direction: LEFT_TO_RIGHT

Lamivudine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: Lamivudine

2.7.2.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040662 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040660 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Nucleus/Stoichiometry/1.0
right: Adenosine diphosphate
right: Lamivudine-triphosphate
spontaneous: false
EC number: 2.7.2.3
left: Lamivudine-diphosphate
left: Adenosine triphosphate
name: Adenosine triphosphate + Lamivudine-diphosphate → Adenosine diphosphate + Lamivudine-triphosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 18132
type: UnificationXref
id: CHEBI:18132
db: ChEBI

2.7.1.74
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040659 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009184 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Nucleus/Stoichiometry/1.0
right: Lamivudine-monophosphate
right: Adenosine diphosphate
spontaneous: false
EC number: 2.7.1.74
left: Lamivudine
left: Adenosine triphosphate
name: Adenosine triphosphate + Lamivudine → Adenosine diphosphate + Lamivudine-monophosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000149
type: ChemicalStructure
structure format: SMILES
structure data: NCCOP(O)(O)=O

3.1.3.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040659 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009184 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000192 Cytoplasm/Stoichiometry/1.0
right: Uridine triphosphate
right: Lamivudine
spontaneous: false
EC number: 3.1.3.-
left: Lamivudine-monophosphate
left: Uridine 5'-diphosphate
name: Lamivudine-monophosphate + Uridine 5'-diphosphate → Lamivudine + Uridine triphosphate
conversion direction: LEFT_TO_RIGHT

Multidrug resistance protein 1
type: Protein
entity reference: Multidrug resistance protein 1

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Multidrug resistance-associated protein 4
type: ProteinReference
xref: Reference/UniProt O15439

Lamivudine
type: SmallMolecule
cellular location: Nucleus
entity reference: Lamivudine

Compound/PW C009184 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lamivudine
stoichiometric coefficient: 1.0

Phosphatidylcholine
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Phosphatidylcholine

Oxygen
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001377
xref: Reference/ChemSpider 952
xref: Reference/KEGG Compound C00007
xref: Reference/ChEBI CHEBI 15379
xref: Reference/PubChem-compound 977
xref: Reference/BioCyc CPD-6641
xref: Reference/CAS 7782-44-7
chemical formula: O2
molecular weight: 31.98983
structure: ChemicalStructure/PW C001065

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Adenosine diphosphate

Reference/HMDB HMDB0060641
type: UnificationXref
id: HMDB0060641
db: HMDB

Solute carrier family 22 member 2
type: Protein
entity reference: Solute carrier family 22 member 2

Reference/PubChem-compound 75607486
type: UnificationXref
id: 75607486
db: PubChem-compound

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/PubChem-compound 75607483
type: UnificationXref
id: 75607483
db: PubChem-compound

ATP-binding cassette sub-family G member 2
type: ProteinReference
xref: Reference/UniProt Q9UNQ0

Lamivudine-diphosphate-choline
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: Lamivudine-diphosphate-choline

Compound/PW C040661 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lamivudine sulfoxide
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040659
type: ChemicalStructure
structure format: SMILES
structure data: NC1=NC(=O)N(C=C1)C1CSC(COP(O)(O)=O)O1

Sulfotransferase 1A1
type: ProteinReference
xref: Reference/UniProt P50225
organism: Homo sapiens

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/CAS 7782-44-7
type: UnificationXref
id: 7782-44-7
db: CAS

Pyrophosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Pyrophosphate

Reference/HMDB HMDB0001377
type: UnificationXref
id: HMDB0001377
db: HMDB

Reference/CAS 107-73-3
type: UnificationXref
id: 107-73-3
db: CAS

Ethanolamine-phosphate cytidylyltransferase
type: ProteinReference
xref: Reference/UniProt Q99447
organism: Homo sapiens

Compound/PW C001065 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Oxygen
stoichiometric coefficient: 1.0

Reference/UniProt Q99447
type: UnificationXref
id: Q99447
db: UniProt

Choline-phosphate cytidylyltransferase A
type: ProteinReference
xref: Reference/UniProt P49585
organism: Homo sapiens

ChemicalStructure/PW C040660
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000285
type: UnificationXref
id: HMDB0000285
db: HMDB

Reference/TAXONOMY 9606
type: UnificationXref
id: 9606
db: TAXONOMY

Solute carrier family 22 member 1
type: ProteinReference
xref: Reference/UniProt O15245

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C001783 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen peroxide
stoichiometric coefficient: 1.0

Canalicular multispecific organic anion transporter 1
type: Protein
cellular location: Cell Membrane
entity reference: Canalicular multispecific organic anion transporter 1

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/CAS 58-98-0
type: UnificationXref
id: 58-98-0
db: CAS

Reference/UniProt O15244
type: UnificationXref
id: O15244
db: UniProt

Reference/UniProt O15245
type: UnificationXref
id: O15245
db: UniProt

Canalicular multispecific organic anion transporter 2
type: ProteinReference
xref: Reference/UniProt O15438

Reference/KEGG Compound C00075
type: UnificationXref
id: C00075
db: KEGG Compound

Compound/PW C040682 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: 1,2-diacylglycerol
stoichiometric coefficient: 1.0

Compound/Generic74 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphatidylcholine
stoichiometric coefficient: 1.0

Compound/PW C001034 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Compound/PW C040659 Golgi Apparatus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lamivudine-monophosphate
stoichiometric coefficient: 1.0

Protein/105 Nucleus/Stoichiometry/6.0
type: Stoichiometry
physical entity: Nucleoside diphosphate kinase A
stoichiometric coefficient: 6.0

ChemicalStructure/PW C001065
type: ChemicalStructure
structure format: SMILES
structure data: O=O

Solute carrier family 22 member 3
type: Protein
entity reference: Solute carrier family 22 member 3

Phosphorylcholine
type: SmallMoleculeReference
xref: Reference/CAS 107-73-3
xref: Reference/HMDB HMDB0001565
xref: Reference/BioCyc PHOSPHORYL-CHOLINE
xref: Reference/PubChem-compound 1014
xref: Reference/ChEBI CHEBI 18132
xref: Reference/KEGG Compound C00588
xref: Reference/ChemSpider 989
chemical formula: C5H15NO4P
molecular weight: 184.07387
structure: ChemicalStructure/PW C001202

Phosphorylcholine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphorylcholine

Reference/HMDB HMDB0000295
type: UnificationXref
id: HMDB0000295
db: HMDB

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Reference/ChemSpider 5809
type: UnificationXref
id: 5809
db: ChemSpider

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Reference/PubChem-compound 75607387
type: UnificationXref
id: 75607387
db: PubChem-compound

Multidrug resistance-associated protein 1
type: ProteinReference
xref: Reference/UniProt P33527

Canalicular multispecific organic anion transporter 2
type: Protein
cellular location: Cell Membrane
entity reference: Canalicular multispecific organic anion transporter 2

Reference/ChEBI CHEBI 15379
type: UnificationXref
id: CHEBI:15379
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Lamivudine sulfoxide
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Lamivudine sulfoxide

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Lamivudine-monophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 75607387
xref: Reference/HMDB HMDB0060641
chemical formula: C8H12N3O6PS
molecular weight: 309.01843
structure: ChemicalStructure/PW C040659

Reference/ChEBI CHEBI 17553
type: UnificationXref
id: CHEBI:17553
db: ChEBI

Compound/PW C000414 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Phosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Phosphate

1,2-diacylglycerol
type: SmallMolecule
cellular location: Golgi Apparatus
entity reference: 1,2-diacylglycerol

Compound/PW C040659 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lamivudine-monophosphate
stoichiometric coefficient: 1.0

2.7.8.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040682 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/Generic74 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040659 Golgi Apparatus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040663 Golgi Apparatus/Stoichiometry/1.0
right: Phosphatidylcholine
right: Lamivudine-monophosphate
spontaneous: false
EC number: 2.7.8.2
left: Lamivudine-diphosphate-choline
left: 1,2-diacylglycerol
name: 1,2-diacylglycerol + Lamivudine-diphosphate-choline → Lamivudine-monophosphate + Phosphatidylcholine
conversion direction: LEFT_TO_RIGHT

Reaction2099
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040659 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040664 Cytoplasm/Stoichiometry/1.0
right: Lamivudine-monophosphate
spontaneous: false
left: Lamivudine-diphosphate-ethanolamine
name: Lamivudine-diphosphate-ethanolamine → Lamivudine-monophosphate
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P15531
type: UnificationXref
id: P15531
db: UniProt

2.7.7.15
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040660 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040663 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001202 Cytoplasm/Stoichiometry/1.0
right: Lamivudine-diphosphate-choline
right: Pyrophosphate
spontaneous: false
EC number: 2.7.7.15
left: Lamivudine-triphosphate
left: Phosphorylcholine
name: Lamivudine-triphosphate + Phosphorylcholine → Lamivudine-diphosphate-choline + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

2.7.7.14
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000149 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040664 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040660 Cytoplasm/Stoichiometry/1.0
right: Lamivudine-diphosphate-ethanolamine
right: Pyrophosphate
spontaneous: false
EC number: 2.7.7.14
left: Lamivudine-triphosphate
left: O-Phosphoethanolamine
name: Lamivudine-triphosphate + O-Phosphoethanolamine → Lamivudine-diphosphate-ethanolamine + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

ATP-binding cassette sub-family G member 2
type: Protein
cellular location: Cytoplasm
entity reference: ATP-binding cassette sub-family G member 2

Reaction2094
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040659 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040662 Nucleus/Stoichiometry/1.0
right: Lamivudine-monophosphate
spontaneous: false
left: Lamivudine-diphosphate
name: Lamivudine-diphosphate → Lamivudine-monophosphate
conversion direction: LEFT_TO_RIGHT

Reaction2095
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040662 Nucleus/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040660 Nucleus/Stoichiometry/1.0
right: Lamivudine-diphosphate
spontaneous: false
left: Lamivudine-triphosphate
name: Lamivudine-triphosphate → Lamivudine-diphosphate
conversion direction: LEFT_TO_RIGHT

Transport204
type: Transport
participant stoichiometry: Compound/PW C009184 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040659 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040659 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009184 Cytoplasm/Stoichiometry/1.0
right: Lamivudine
right: Lamivudine-monophosphate
spontaneous: false
left: Lamivudine-monophosphate
left: Lamivudine
name: Lamivudine (→), Lamivudine-monophosphate (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Compound/PW C040660 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lamivudine-triphosphate
stoichiometric coefficient: 1.0

Transport203
type: Transport
participant stoichiometry: Compound/PW C009184 Extracellular Space/Stoichiometry/1.0
participant stoichiometry: Compound/PW C009184 Cytoplasm/Stoichiometry/1.0
right: Lamivudine
spontaneous: false
left: Lamivudine
name: Lamivudine (→) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Cytoplasm
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0060599
type: UnificationXref
id: HMDB0060599
db: HMDB

Lamivudine-triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 75607486
xref: Reference/HMDB HMDB0060640
chemical formula: C8H14N3O12P3S
molecular weight: 468.9511
structure: ChemicalStructure/PW C040660

Lamivudine sulfoxide
type: SmallMoleculeReference
xref: Reference/ChemSpider 398148
xref: Reference/PubChem-compound 452020
xref: Reference/HMDB HMDB0060599
chemical formula: C8H11N3O4S
molecular weight: 245.04703
structure: ChemicalStructure/PW C040661

Lamivudine-diphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061354
xref: Reference/PubChem-compound 75607483
chemical formula: C8H13N3O9P2S
molecular weight: 388.98477
structure: ChemicalStructure/PW C040662

Phosphoglycerate kinase 1
type: ProteinReference
xref: Reference/UniProt P00558
organism: Homo sapiens

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Lamivudine-diphosphate-choline
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061355
chemical formula: C10H19N4O9P2S
molecular weight: 433.0348
structure: ChemicalStructure/PW C040663

Lamivudine-diphosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Lamivudine-diphosphate

Lamivudine-diphosphate-ethanolamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0061356
chemical formula: C10H18N4O9P2S
molecular weight: 432.02698
structure: ChemicalStructure/PW C040664

Lamivudine-triphosphate
type: SmallMolecule
cellular location: Cytoplasm
entity reference: Lamivudine-triphosphate

Lamivudine Metabolism Pathway
type: Pathway
pathway order: PathwayEnzymeReaction/3674
pathway order: PathwayEnzymeReaction/3675
pathway order: PathwayEnzymeReaction/2752
pathway order: PathwayEnzymeReaction/300595
pathway order: PathwayEnzymeReaction/2770
pathway order: PathwayEnzymeReaction/2771
pathway order: PathwayEnzymeReaction/2750
pathway order: PathwayTransport/2773
pathway order: PathwayEnzymeReaction/3680
pathway order: PathwaySubPathway/668
pathway order: PathwayEnzymeReaction/3682
pathway order: PathwayEnzymeReaction/2745
pathway order: PathwayTransport/2754
pathway order: PathwayTransport/2755
pathway order: PathwayEnzymeReaction/2748
pathway order: PathwayTransport/2753
pathway order: PathwayEnzymeReaction/2741
pathway order: PathwayEnzymeReaction/3676
pathway order: PathwayTransport/2737
pathway order: PathwayEnzymeReaction/3677
pathway order: PathwayEnzymeReaction/2743
pathway order: PathwayTransport/2756
pathway order: PathwayEnzymeReaction/3678
pathway order: PathwayEnzymeReaction/2744
pathway order: PathwayTransport/2757
pathway order: PathwayTransport/2738
pathway order: PathwayTransport/2739
pathway order: PathwayEnzymeReaction/2749
pathway component: TransportCatalysis165
pathway component: TransportCatalysis164
pathway component: TransportCatalysis163
pathway component: Reaction2092
pathway component: 2.7.2.3
pathway component: 2.7.1.74
pathway component: 3.1.3.-
pathway component: SubPathwayControl668
pathway component: ReactionCoupledTransportCatalysis93
pathway component: ReactionCoupledTransportCatalysis96
pathway component: ReactionCatalysis1966
pathway component: ReactionCatalysis1968
pathway component: ReactionCoupledTransportCatalysis92
pathway component: ReactionCatalysis1967
pathway component: ReactionCoupledTransportCatalysis91
pathway component: 2.8.2.1
pathway component: TransportCatalysis171
pathway component: TransportCatalysis170
pathway component: ReactionCoupledTransportCatalysis101
pathway component: ReactionCoupledTransportCatalysis100
pathway component: ReactionCatalysis1969
pathway component: ReactionCatalysis1973
pathway component: ReactionCatalysis1972
pathway component: 3.6.3.44
pathway component: 2.7.8.2
pathway component: Reaction2099
pathway component: ReactionCoupledTransport75
pathway component: 2.7.7.15
pathway component: ReactionCatalysis1976
pathway component: 2.7.7.14
pathway component: Reaction2094
pathway component: Reaction2095
pathway component: TransportCatalysis169
pathway component: TransportCatalysis168
pathway component: Transport204
pathway component: TransportCatalysis167
pathway component: ReactionCatalysis1971
pathway component: Transport203
pathway component: ReactionCatalysis1970
pathway component: TransportCatalysis166
xref: Reference/SMPDB SMP0000649
xref: Reference/PathWhiz PW000625
organism: Homo sapiens

Canalicular multispecific organic anion transporter 1
type: ProteinReference
xref: Reference/UniProt Q92887

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Hydrogen peroxide
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0003125
xref: Reference/PubChem-compound 784
xref: Reference/ChemSpider 763
xref: Reference/CAS 7722-84-1
xref: Reference/BioCyc HYDROGEN-PEROXIDE
xref: Reference/ChEBI CHEBI 16240
xref: Reference/KEGG Compound C00027
chemical formula: H2O2
molecular weight: 34.005478
structure: ChemicalStructure/PW C001783

Reference/ChemSpider 990
type: UnificationXref
id: 990
db: ChemSpider

Nucleus
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005634

ChemicalStructure/PW C000192
type: ChemicalStructure
structure format: SMILES

Reference/CAS 63-39-8
type: UnificationXref
id: 63-39-8
db: CAS

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Deoxycytidine kinase
type: Protein
cellular location: Nucleus
entity reference: Deoxycytidine kinase

Reference/UniProt Q9UNQ0
type: UnificationXref
id: Q9UNQ0
db: UniProt

Reference/ChEBI CHEBI 17659
type: UnificationXref
id: CHEBI:17659
db: ChEBI

Reference/PubChem-compound 977
type: UnificationXref
id: 977
db: PubChem-compound

Compound/PW C009184 Nucleus/Stoichiometry/1.0
type: Stoichiometry
physical entity: Lamivudine
stoichiometric coefficient: 1.0

Reference/UniProt Q8WUD6
type: UnificationXref
id: Q8WUD6
db: UniProt

Multidrug resistance protein 1
type: ProteinReference
xref: Reference/UniProt P08183

Reference/UniProt P33527
type: UnificationXref
id: P33527
db: UniProt

Reference/ChemSpider 989
type: UnificationXref
id: 989
db: ChemSpider

Adenosine triphosphate
type: SmallMolecule
cellular location: Nucleus
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Adenosine diphosphate

Reference/KEGG Compound C07065
type: UnificationXref
id: C07065
db: KEGG Compound

Nucleoside diphosphate kinase A
type: Complex
component stoichiometry: Protein/105 Nucleus/Stoichiometry/6.0
cellular location: Nucleus
component: Nucleoside diphosphate kinase A

Reference/ChemSpider 54812
type: UnificationXref
id: 54812
db: ChemSpider