Para-aminobenzoate synthase glutamine amidotransferase component II
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine ↔ 7,8-dihydroneopterin 3'-triphosphate + Water
2,5-Diaminopyrimidine nucleoside triphosphate → 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
Formamidopyrimidine nucleoside triphosphate + Water → 2,5-Diaminopyrimidine nucleoside triphosphate + Formic acid
Guanosine triphosphate + Water → Formamidopyrimidine nucleoside triphosphate
Dihydroneopterin triphosphate pyrophosphatase
7,8-Dihydroneopterin → 6-hydroxymethyl-7,8-dihydropterin + Glycolaldehyde
7,8-dihydroneopterin 3'-phosphate + Water → 7,8-Dihydroneopterin + Phosphate
7,8-dihydroneopterin 3'-triphosphate + Water → 7,8-dihydroneopterin 3'-phosphate + Hydrogen Ion + Pyrophosphate
Guanosine triphosphate + Water → 7,8-dihydroneopterin 3'-triphosphate + Formic acid + Hydrogen Ion
p-aminobenzoyl-glutamate hydrolase subunit B
2,5-Diaminopyrimidine nucleoside triphosphate
Formamidopyrimidine nucleoside triphosphate
Water + p-Aminobenzoyl glutamate → L-Glutamic acid + p-Aminobenzoic acid
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
p-aminobenzoyl-glutamate hydrolase subunit A
7,8-dihydrofolate monoglutamate + Hydrogen Ion + NADPH → NADP + Tetrahydrofolic acid
7,8-Dihydropteroic acid + Adenosine triphosphate + L-Glutamic acid → 7,8-dihydrofolate monoglutamate + Adenosine diphosphate + Hydrogen Ion + Phosphate
Chorismate + L-Glutamine → 4-amino-4-deoxychorismate + L-Glutamic acid
4-amino-4-deoxychorismate → Hydrogen Ion + Pyruvic acid + p-Aminobenzoic acid
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + p-Aminobenzoic acid → 7,8-Dihydropteroic acid + Pyrophosphate
6-hydroxymethyl-7,8-dihydropterin + Adenosine triphosphate → (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + Adenosine monophosphate + Hydrogen Ion