Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Reference/UniProt P28248
type: UnificationXref
id: P28248
db: UniProt

Reference/CAS 365-07-1
type: UnificationXref
id: 365-07-1
db: CAS

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

Reference/CAS 964-26-1
type: UnificationXref
id: 964-26-1
db: CAS

Compound/PW C001189 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: CDP
stoichiometric coefficient: 1.0

Reference/ChemSpider 58580
type: UnificationXref
id: 58580
db: ChemSpider

Ribonucleoside-diphosphate reductase 2 subunit beta
type: ProteinReference
xref: Reference/UniProt P37146
organism: BiologicalState304

BiologicalState304
type: BioSource
xref: Reference/TAXONOMY 2
name: Bacteria

dUDP
type: SmallMolecule
cellular location: Cytosol
entity reference: dUDP

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/PubChem-compound 6133
type: UnificationXref
id: 6133
db: PubChem-compound

Reference/ChEBI CHEBI 16389
type: UnificationXref
id: CHEBI:16389
db: ChEBI

Reference/PubChem-compound 6132
type: UnificationXref
id: 6132
db: PubChem-compound

Pyrimidine Metabolism
type: Pathway
pathway order: PathwayEnzymeReaction/7098
pathway order: PathwayEnzymeReaction/7131
pathway order: PathwayEnzymeReaction/7099
pathway order: PathwayEnzymeReaction/7110
pathway order: PathwayEnzymeReaction/7097
pathway order: PathwaySubPathway/109868
pathway order: PathwaySubPathway/109867
pathway order: PathwayEnzymeReaction/7116
pathway order: PathwayEnzymeReaction/7108
pathway order: PathwayEnzymeReaction/2122853
pathway order: PathwayEnzymeReaction/2122854
pathway order: PathwayEnzymeReaction/2122855
pathway order: PathwayEnzymeReaction/2122858
pathway order: PathwayEnzymeReaction/7106
pathway order: PathwayEnzymeReaction/7107
pathway order: PathwayEnzymeReaction/8415
pathway order: PathwayEnzymeReaction/7104
pathway order: PathwayEnzymeReaction/8414
pathway order: PathwayEnzymeReaction/7105
pathway order: PathwayEnzymeReaction/7103
pathway order: PathwayEnzymeReaction/7122
pathway order: PathwayEnzymeReaction/2122860
pathway order: PathwayEnzymeReaction/2122861
pathway order: PathwayEnzymeReaction/2123576
pathway order: PathwayEnzymeReaction/2122862
pathway order: PathwayEnzymeReaction/2122863
pathway component: PRPP Biosynthesis
pathway component: 2.7.4.22
pathway component: ReactionCatalysis3525
pathway component: 4.1.1.23
pathway component: ReactionCatalysis3523
pathway component: ReactionCatalysis3524
pathway component: ReactionCatalysis3507
pathway component: ReactionCatalysis3508
pathway component: Reaction6749
pathway component: ReactionCatalysis3527
pathway component: L-glutamate metabolism II
pathway component: ReactionCatalysis3506
pathway component: 3.6.1.23
pathway component: Reaction3538
pathway component: Reaction3537
pathway component: ReactionCatalysis2670
pathway component: Reaction3536
pathway component: 1.17.4.1
pathway component: ReactionCatalysis3521
pathway component: ReactionCatalysis6712
pathway component: Reaction3534
pathway component: ReactionCatalysis3522
pathway component: 6.3.4.2
pathway component: 2.7.4.6
pathway component: ReactionCatalysis3520
pathway component: 2.4.2.10
pathway component: ReactionCatalysis3509
pathway component: ReactionCatalysis3514
pathway component: Reaction3542
pathway component: Reaction3541
pathway component: ReactionCatalysis3515
pathway component: ReactionCatalysis3512
pathway component: 2.1.1.45
pathway component: ReactionCatalysis3513
pathway component: ReactionCatalysis3518
pathway component: ReactionCatalysis3519
pathway component: ReactionCatalysis3516
pathway component: ReactionCatalysis3517
pathway component: 1.3.5.2
pathway component: 3.5.2.3
pathway component: 2.1.3.2
pathway component: ReactionCatalysis3510
pathway component: 3.5.4.13
pathway component: 6.3.5.5
pathway component: ReactionCatalysis3511
pathway component: Reaction3544
pathway component: Reaction3543
xref: Reference/PathWhiz PW000942
xref: Reference/SMPDB SMP0000959
organism: Escherichia coli

Dihydrofolic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00415
xref: Reference/BioCyc DIHYDROFOLATE
xref: Reference/ChEBI CHEBI 15633
xref: Reference/ChemSpider 89228
xref: Reference/PubChem-compound 98792
xref: Reference/HMDB HMDB0001056
xref: Reference/CAS 4033-27-6
chemical formula: C19H21N7O6
molecular weight: 443.15533
structure: ChemicalStructure/PW C000831

Reference/ChEBI CHEBI 17239
type: UnificationXref
id: CHEBI:17239
db: ChEBI

Reference/HMDB HMDB0001191
type: UnificationXref
id: HMDB0001191
db: HMDB

5-Thymidylic acid
type: SmallMoleculeReference
xref: Reference/BioCyc TMP
xref: Reference/PubChem-compound 9700
xref: Reference/HMDB HMDB0001227
xref: Reference/ChemSpider 9319
xref: Reference/CAS 365-07-1
xref: Reference/KEGG Compound C00364
xref: Reference/ChEBI CHEBI 17013
chemical formula: C10H15N2O8P
molecular weight: 322.0566
structure: ChemicalStructure/PW C000950

Reference/UniProt P52006
type: UnificationXref
id: P52006
db: UniProt

dCDP
type: SmallMolecule
entity reference: dCDP

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Ammonium
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0041827
xref: Reference/CAS 14798-03-9
xref: Reference/PubChem-compound 16741146
xref: Reference/KEGG Compound C01342
xref: Reference/ChEBI CHEBI 28938
xref: Reference/ChemSpider 218
chemical formula: H4N
molecular weight: 18.034374
structure: ChemicalStructure/PW C022608

Reference/ChEBI CHEBI 17111
type: UnificationXref
id: CHEBI:17111
db: ChEBI

Reaction3542
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/Generic97/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000790/Stoichiometry/1.0
participant stoichiometry: Compound/Generic96/Stoichiometry/1.0
right: an oxidized flavodoxin
right: dCTP
right: Water
spontaneous: false
left: a reduced flavodoxin
left: Cytidine triphosphate
name: Cytidine triphosphate + a reduced flavodoxin → Water + an oxidized flavodoxin + dCTP
conversion direction: LEFT_TO_RIGHT

Reaction3541
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001035/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000987/Stoichiometry/1.0
right: Adenosine diphosphate
right: Thymidine 5'-triphosphate
spontaneous: false
left: dTDP
left: Adenosine triphosphate
name: Adenosine triphosphate + dTDP → Adenosine diphosphate + Thymidine 5'-triphosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

2.1.1.45
type: BiochemicalReaction
participant stoichiometry: Compound/PW C042908/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000831/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000950/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001087/Stoichiometry/1.0
right: Dihydrofolic acid
right: 5-Thymidylic acid
spontaneous: false
EC number: 2.1.1.45
left: 5,10-methenyltetrahydrofolate mono-L-glutamate
left: dUMP
name: 5,10-methenyltetrahydrofolate mono-L-glutamate + dUMP → 5-Thymidylic acid + Dihydrofolic acid
conversion direction: LEFT_TO_RIGHT

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

3.5.4.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C022608/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000790/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000927/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Deoxyuridine triphosphate
right: Ammonium
spontaneous: false
EC number: 3.5.4.13
left: dCTP
left: Water
left: Hydrogen Ion
name: Hydrogen Ion + Water + dCTP → Ammonium + Deoxyuridine triphosphate
conversion direction: LEFT_TO_RIGHT

Protein/5878/Stoichiometry/2.0
type: Stoichiometry
physical entity: Dihydroorotase
stoichiometric coefficient: 2.0

Reaction3544
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000962 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic99 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic98 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001189 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
right: an oxidized NrdH glutaredoxin-like protein
right: dCDP
right: Water
spontaneous: false
left: CDP
left: a reduced NrdH glutaredoxin-like protein
name: CDP + a reduced NrdH glutaredoxin-like protein → Water + an oxidized NrdH glutaredoxin-like protein + dCDP
conversion direction: LEFT_TO_RIGHT

Reference/CAS 63-38-7
type: UnificationXref
id: 63-38-7
db: CAS

Reaction3543
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/Generic97/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000192/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000927/Stoichiometry/1.0
participant stoichiometry: Compound/Generic96/Stoichiometry/1.0
right: an oxidized flavodoxin
right: Deoxyuridine triphosphate
right: Water
spontaneous: false
left: a reduced flavodoxin
left: Uridine triphosphate
name: Uridine triphosphate + a reduced flavodoxin → Deoxyuridine triphosphate + Water + an oxidized flavodoxin
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00459
type: UnificationXref
id: C00459
db: KEGG Compound

Reference/KEGG Compound C00337
type: UnificationXref
id: C00337
db: KEGG Compound

Reference/KEGG Compound C00458
type: UnificationXref
id: C00458
db: KEGG Compound

SubPathwayInteraction109867
type: Interaction
name: SubPathway109867Reaction
name: SubPathwayReaction
participant: Phosphoribosyl pyrophosphate

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc HCO3
type: UnificationXref
id: HCO3
db: BioCyc

Reference/ChemSpider 5745
type: UnificationXref
id: 5745
db: ChemSpider

SubPathwayInteraction109868
type: Interaction
name: SubPathwayReaction
name: SubPathway109868Reaction
participant: L-Glutamine

Dihydrofolic acid
type: SmallMolecule
entity reference: Dihydrofolic acid

Carbamoyl-phosphate synthase small chain
type: Protein
entity reference: Carbamoyl-phosphate synthase small chain

Reference/CAS 365-08-2
type: UnificationXref
id: 365-08-2
db: CAS

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Ribonucleoside-diphosphate reductase 1 subunit beta
type: Protein
entity reference: Ribonucleoside-diphosphate reductase 1 subunit beta

5-Thymidylic acid
type: SmallMolecule
entity reference: 5-Thymidylic acid

Reference/UniProt P05020
type: UnificationXref
id: P05020
db: UniProt

Reference/BioCyc L-ASPARTATE
type: UnificationXref
id: L-ASPARTATE
db: BioCyc

Deoxyuridine triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 65070
xref: Reference/BioCyc DUTP
xref: Reference/CAS 1173-82-6
xref: Reference/HMDB HMDB0001191
xref: Reference/ChEBI CHEBI 17625
xref: Reference/KEGG Compound C00460
xref: Reference/ChemSpider 58580
chemical formula: C9H15N2O14P3
molecular weight: 467.9736
structure: ChemicalStructure/PW C000927

Carbamoyl-phosphate synthase large chain
type: Protein
entity reference: Carbamoyl-phosphate synthase large chain

Deoxycytidine triphosphate deaminase
type: ProteinReference
xref: Reference/UniProt P28248

ChemicalStructure/PW C001087
type: ChemicalStructure
structure format: SMILES

Reference/CAS 7540-64-9
type: UnificationXref
id: 7540-64-9
db: CAS

Reference/PubChem-compound 64968
type: UnificationXref
id: 64968
db: PubChem-compound

Reference/UniProt P0AEY3
type: UnificationXref
id: P0AEY3
db: UniProt

Compound/PW C000962/Stoichiometry/1.0
type: Stoichiometry
physical entity: dCDP
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00105
type: UnificationXref
id: C00105
db: KEGG Compound

Reference/PubChem-compound 6030
type: UnificationXref
id: 6030
db: PubChem-compound

Reference/PubChem-compound 6031
type: UnificationXref
id: 6031
db: PubChem-compound

Reference/CAS 800-73-7
type: UnificationXref
id: 800-73-7
db: CAS

Dihydroorotase
type: Protein
entity reference: Dihydroorotase

Reference/ChemSpider 58493
type: UnificationXref
id: 58493
db: ChemSpider

Reference/KEGG Compound C00460
type: UnificationXref
id: C00460
db: KEGG Compound

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

Reference/ChEBI CHEBI 15033
type: UnificationXref
id: CHEBI:15033
db: ChEBI

Reference/ChemSpider 942
type: UnificationXref
id: 942
db: ChemSpider

Anaerobic ribonucleoside-triphosphate reductase
type: ProteinReference
xref: Reference/UniProt P28903

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Uridine 5'-diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine 5'-diphosphate

Compound/Generic98 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: an oxidized NrdH glutaredoxin-like protein
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001096
type: UnificationXref
id: HMDB0001096
db: HMDB

Protein/5946/Stoichiometry/2.0
type: Stoichiometry
physical entity: Orotidine 5'-phosphate decarboxylase
stoichiometric coefficient: 2.0

Reference/PubChem-compound 21960964
type: UnificationXref
id: 21960964
db: PubChem-compound

Protein/10849 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribonucleoside-diphosphate reductase small chain 2
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00119
type: UnificationXref
id: C00119
db: KEGG Compound

Reference/PubChem-compound 160617
type: UnificationXref
id: 160617
db: PubChem-compound

ChemicalStructure/PW C000927
type: ChemicalStructure
structure format: SMILES

dTDP
type: SmallMoleculeReference
xref: Reference/CAS 491-97-4
xref: Reference/ChemSpider 144320
xref: Reference/PubChem-compound 164628
xref: Reference/KEGG Compound C00363
xref: Reference/ChEBI CHEBI 18075
xref: Reference/HMDB HMDB0001274
xref: Reference/BioCyc TDP
chemical formula: C10H16N2O11P2
molecular weight: 402.02292
structure: ChemicalStructure/PW C000987

Ammonium
type: SmallMolecule
entity reference: Ammonium

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

Carbamoyl phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 278
xref: Reference/BioCyc CARBAMOYL-P
xref: Reference/ChemSpider 272
xref: Reference/HMDB HMDB0001096
xref: Reference/CAS 590-55-6
xref: Reference/KEGG Compound C00169
xref: Reference/ChEBI CHEBI 17672
chemical formula: CH4NO5P
molecular weight: 140.98271
structure: ChemicalStructure/PW C000862

Compound/Generic99 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: a reduced NrdH glutaredoxin-like protein
stoichiometric coefficient: 1.0

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

Reference/KEGG Compound C00112
type: UnificationXref
id: C00112
db: KEGG Compound

Reference/UniProt P0A763
type: UnificationXref
id: P0A763
db: UniProt

Reference/UniProt P0A884
type: UnificationXref
id: P0A884
db: UniProt

Compound/PW C000463/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen carbonate
stoichiometric coefficient: 1.0

Reaction6749
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000792 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic99 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/Generic98 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201 Cytosol/Stoichiometry/1.0
right: an oxidized NrdH glutaredoxin-like protein
right: dUDP
right: Water
spontaneous: false
left: Uridine 5'-diphosphate
left: a reduced NrdH glutaredoxin-like protein
name: Uridine 5'-diphosphate + a reduced NrdH glutaredoxin-like protein → Water + an oxidized NrdH glutaredoxin-like protein + dUDP
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P39452
type: UnificationXref
id: P39452
db: UniProt

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/ChemSpider 4307
type: UnificationXref
id: 4307
db: ChemSpider

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Compound/PW C000500/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Reference/KEGG Compound C00364
type: UnificationXref
id: C00364
db: KEGG Compound

Reference/BioCyc CTP
type: UnificationXref
id: CTP
db: BioCyc

Reference/KEGG Compound C00363
type: UnificationXref
id: C00363
db: KEGG Compound

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

4,5-Dihydroorotic acid
type: SmallMolecule
entity reference: 4,5-Dihydroorotic acid

Protein mazG
type: ProteinReference
xref: Reference/UniProt P0AEY3
organism: BiologicalState304

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Reference/KEGG Compound C00365
type: UnificationXref
id: C00365
db: KEGG Compound

Protein/6034 Cytosol/Stoichiometry/4.0
type: Stoichiometry
physical entity: Nucleoside diphosphate kinase
stoichiometric coefficient: 4.0

Compound/PW C001034/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 2.0

Reference/UniProt P37146
type: UnificationXref
id: P37146
db: UniProt

Compound/PW C000927 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyuridine triphosphate
stoichiometric coefficient: 1.0

Compound/PW C042935/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-carbamoyl-L-aspartate
stoichiometric coefficient: 1.0

Reference/CAS 65-86-1
type: UnificationXref
id: 65-86-1
db: CAS

Compound/PW C000201 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

Protein/6036/Stoichiometry/6.0
type: Stoichiometry
physical entity: Aspartate carbamoyltransferase catalytic chain
stoichiometric coefficient: 6.0

PRPP Biosynthesis
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109867
pathway component: SubPathwayInteraction109867
xref: Reference/PathWhiz PW000909
xref: Reference/SMPDB SMP0000926
name: SubPathway

dCDP
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0001245
xref: Reference/ChemSpider 132961
xref: Reference/KEGG Compound C00705
xref: Reference/ChEBI CHEBI 28846
xref: Reference/CAS 800-73-7
xref: Reference/PubChem-compound 150855
xref: Reference/BioCyc DCDP
chemical formula: C9H15N3O10P2
molecular weight: 387.02325
structure: ChemicalStructure/PW C000962

Reference/PubChem-compound 44367445
type: UnificationXref
id: 44367445
db: PubChem-compound

Reference/PubChem-compound 447920
type: UnificationXref
id: 447920
db: PubChem-compound

Reference/KEGG Compound C00011
type: UnificationXref
id: C00011
db: KEGG Compound

Reference/KEGG Compound C01342
type: UnificationXref
id: C01342
db: KEGG Compound

deoxyuridine triphosphatase
type: Complex
component stoichiometry: Protein/5906 Cytosol/Stoichiometry/3.0
cellular location: Cytosol
component: Deoxyuridine 5'-triphosphate nucleotidohydrolase

Reference/PubChem-compound 7339
type: UnificationXref
id: 7339
db: PubChem-compound

Reference/KEGG Compound C00015
type: UnificationXref
id: C00015
db: KEGG Compound

Reference/KEGG Compound C01346
type: UnificationXref
id: C01346
db: KEGG Compound

Reference/KEGG Compound C01103
type: UnificationXref
id: C01103
db: KEGG Compound

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Reference/UniProt P0A786
type: UnificationXref
id: P0A786
db: UniProt

L-glutamate metabolism II
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109868
pathway component: SubPathwayInteraction109868
xref: Reference/PathWhiz PW001886
xref: Reference/SMPDB SMP0001900
name: SubPathway

Protein/5860/Stoichiometry/2.0
type: Stoichiometry
physical entity: Carbamoyl-phosphate synthase large chain
stoichiometric coefficient: 2.0

Reference/TAXONOMY 562
type: UnificationXref
id: 562
db: TAXONOMY

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Compound/PW C000190 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoribosyl pyrophosphate
stoichiometric coefficient: 1.0

Compound/PW C001035/Stoichiometry/1.0
type: Stoichiometry
physical entity: Thymidine 5'-triphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 58574
type: UnificationXref
id: 58574
db: ChemSpider

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine
name: SubPathwayOutput

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Carbamoyl phosphate
type: SmallMolecule
entity reference: Carbamoyl phosphate

Reference/ChEBI CHEBI 17013
type: UnificationXref
id: CHEBI:17013
db: ChEBI

Aspartate carbamoyltransferase catalytic chain
type: ProteinReference
xref: Reference/UniProt P0A786

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

dTDP
type: SmallMolecule
entity reference: dTDP

Nucleoside diphosphate kinase
type: ProteinReference
xref: Reference/UniProt P0A763

Compound/PW C042908/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5,10-methenyltetrahydrofolate mono-L-glutamate
stoichiometric coefficient: 1.0

Reference/BioCyc TTP
type: UnificationXref
id: TTP
db: BioCyc

Compound/PW C042948/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquinol-1
stoichiometric coefficient: 1.0

Compound/PW C000201/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-diphosphate
stoichiometric coefficient: 1.0

Deoxyuridine 5'-triphosphate nucleotidohydrolase
type: Protein
cellular location: Cytosol
entity reference: Deoxyuridine 5'-triphosphate nucleotidohydrolase

Protein/6257 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Protein mazG
stoichiometric coefficient: 2.0

Reference/PubChem-compound 769
type: UnificationXref
id: 769
db: PubChem-compound

Reference/PubChem-compound 648
type: UnificationXref
id: 648
db: PubChem-compound

Reference/BioCyc DCDP
type: UnificationXref
id: DCDP
db: BioCyc

Reference/KEGG Compound C00399
type: UnificationXref
id: C00399
db: KEGG Compound

Reference/SMPDB SMP0000926
type: UnificationXref
id: SMP0000926
db: SMPDB

Compound/PW C000862/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbamoyl phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 128553
type: UnificationXref
id: 128553
db: ChemSpider

Reference/PubChem-compound 46878371
type: UnificationXref
id: 46878371
db: PubChem-compound

Aspartate carbamoyltransferase regulatory chain
type: ProteinReference
xref: Reference/UniProt P0A7F3

Uridylate kinase
type: ProteinReference
xref: Reference/UniProt P0A7E9

Water
type: SmallMolecule
entity reference: Water

CTP synthase
type: ProteinReference
xref: Reference/UniProt P0A7E5

Orotate phosphoribosyltransferase
type: ProteinReference
xref: Reference/UniProt P0A7E3
organism: BiologicalState304

Dihydroorotate dehydrogenase
type: ProteinReference
xref: Reference/UniProt P0A7E1

Reference/HMDB HMDB0001227
type: UnificationXref
id: HMDB0001227
db: HMDB

Ribonucleoside-diphosphate reductase small chain 2
type: ProteinReference
xref: Reference/UniProt P49723
organism: BiologicalState304

Ribonucleoside-diphosphate reductase large chain 1
type: ProteinReference
xref: Reference/UniProt P21524
organism: BiologicalState304

ChemicalStructure/PW C000057
type: ChemicalStructure
structure format: SMILES

dUDP
type: SmallMoleculeReference
xref: Reference/BioCyc DUDP
xref: Reference/PubChem-compound 145729
xref: Reference/CAS 4208-67-7
xref: Reference/KEGG Compound C01346
xref: Reference/HMDB HMDB0001000
xref: Reference/ChEBI CHEBI 28850
xref: Reference/ChemSpider 128553
chemical formula: C9H14N2O11P2
molecular weight: 388.0073
structure: ChemicalStructure/PW C000792

Reference/PubChem-compound 98792
type: UnificationXref
id: 98792
db: PubChem-compound

dCTP
type: SmallMoleculeReference
xref: Reference/CAS 2056-98-6
xref: Reference/PubChem-compound 65091
xref: Reference/ChEBI CHEBI 16311
xref: Reference/KEGG Compound C00458
xref: Reference/ChemSpider 58601
xref: Reference/HMDB HMDB0000998
xref: Reference/BioCyc DCTP
chemical formula: C9H16N3O13P3
molecular weight: 466.9896
structure: ChemicalStructure/PW C000790

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

Reference/HMDB HMDB0001342
type: UnificationXref
id: HMDB0001342
db: HMDB

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

Reference/SMPDB SMP0001900
type: UnificationXref
id: SMP0001900
db: SMPDB

Uridine 5'-diphosphate
type: SmallMolecule
entity reference: Uridine 5'-diphosphate

Reference/KEGG Compound C00049
type: UnificationXref
id: C00049
db: KEGG Compound

ChemicalStructure/PW C042935
type: ChemicalStructure
structure format: SMILES
structure data: OC(=N)NC(CC([O-])=O)C([O-])=O

Reference/KEGG Compound C00169
type: UnificationXref
id: C00169
db: KEGG Compound

Reference/KEGG Compound C00288
type: UnificationXref
id: C00288
db: KEGG Compound

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/CAS 58-97-9
type: UnificationXref
id: 58-97-9
db: CAS

Reference/BioCyc DIHYDROFOLATE
type: UnificationXref
id: DIHYDROFOLATE
db: BioCyc

Reference/ChemSpider 7062
type: UnificationXref
id: 7062
db: ChemSpider

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

ChemicalStructure/PW C001035
type: ChemicalStructure
structure format: SMILES

dCDP
type: SmallMolecule
cellular location: Cytosol
entity reference: dCDP

Uridine 5'-diphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17659
xref: Reference/PubChem-compound 6031
xref: Reference/CAS 58-98-0
xref: Reference/HMDB HMDB0000295
xref: Reference/KEGG Compound C00015
xref: Reference/ChemSpider 5809
xref: Reference/BioCyc UDP
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C000201

Reference/BioCyc UTP
type: UnificationXref
id: UTP
db: BioCyc

Reference/ChemSpider 5902
type: UnificationXref
id: 5902
db: ChemSpider

4,5-Dihydroorotic acid
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00337
xref: Reference/BioCyc DI-H-OROTATE
xref: Reference/PubChem-compound 648
xref: Reference/ChEBI CHEBI 30865
xref: Reference/CAS 155-54-4
xref: Reference/ChemSpider 628
xref: Reference/HMDB HMDB0000528
chemical formula: C5H6N2O4
molecular weight: 158.03276
structure: ChemicalStructure/PW C000406

Reference/BioCyc DI-H-OROTATE
type: UnificationXref
id: DI-H-OROTATE
db: BioCyc

Reference/ChemSpider 5903
type: UnificationXref
id: 5903
db: ChemSpider

Nucleoside triphosphatase nudI
type: Protein
cellular location: Cytosol
entity reference: Nucleoside triphosphatase nudI

Reference/KEGG Compound C00295
type: UnificationXref
id: C00295
db: KEGG Compound

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

ChemicalStructure/PW C042948
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(O)C(C)=C(CC=C(C)C)C(O)=C1OC

Reference/HMDB HMDB0001245
type: UnificationXref
id: HMDB0001245
db: HMDB

dCTP
type: SmallMolecule
entity reference: dCTP

ChemicalStructure/PW C000151
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1=CC(=O)NC(=O)N1

Reference/KEGG Compound C00063
type: UnificationXref
id: C00063
db: KEGG Compound

Reference/PubChem-compound 145729
type: UnificationXref
id: 145729
db: PubChem-compound

dUDP
type: SmallMolecule
entity reference: dUDP

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Protein/6034/Stoichiometry/4.0
type: Stoichiometry
physical entity: Nucleoside diphosphate kinase
stoichiometric coefficient: 4.0

Reference/CAS 590-55-6
type: UnificationXref
id: 590-55-6
db: CAS

Compound/PW C000192/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine triphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001000
type: UnificationXref
id: HMDB0001000
db: HMDB

Reference/BioCyc DUDP
type: UnificationXref
id: DUDP
db: BioCyc

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/ChEBI CHEBI 17053
type: UnificationXref
id: CHEBI:17053
db: ChEBI

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Compound/Generic72/Stoichiometry/1.0
type: Stoichiometry
physical entity: oxidized thioredoxin
stoichiometric coefficient: 1.0

Protein/10848 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribonucleoside-diphosphate reductase large chain 1
stoichiometric coefficient: 1.0

Reference/SMPDB SMP0000959
type: UnificationXref
id: SMP0000959
db: SMPDB

Compound/PW C000144/Stoichiometry/1.0
type: Stoichiometry
physical entity: Orotidylic acid
stoichiometric coefficient: 1.0

Reference/CAS 4033-27-6
type: UnificationXref
id: 4033-27-6
db: CAS

Thymidylate synthase
type: ProteinReference
xref: Reference/UniProt P0A884

Reference/HMDB HMDB0000288
type: UnificationXref
id: HMDB0000288
db: HMDB

Reference/CAS 65-47-4
type: UnificationXref
id: 65-47-4
db: CAS

Reference/ChemSpider 132961
type: UnificationXref
id: 132961
db: ChemSpider

Reference/HMDB HMDB0000280
type: UnificationXref
id: HMDB0000280
db: HMDB

Compound/PW C000927/Stoichiometry/1.0
type: Stoichiometry
physical entity: Deoxyuridine triphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000285
type: UnificationXref
id: HMDB0000285
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Compound/PW C001347/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ubiquinone-1
stoichiometric coefficient: 1.0

Reference/PubChem-compound 967
type: UnificationXref
id: 967
db: PubChem-compound

Reference/BioCyc OROTATE
type: UnificationXref
id: OROTATE
db: BioCyc

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/CAS 58-98-0
type: UnificationXref
id: 58-98-0
db: CAS

Reference/ChEBI CHEBI 18077
type: UnificationXref
id: CHEBI:18077
db: ChEBI

Carbon dioxide
type: SmallMoleculeReference
xref: Reference/PubChem-compound 280
xref: Reference/ChEBI CHEBI 16526
xref: Reference/ChemSpider 274
xref: Reference/HMDB HMDB0001967
xref: Reference/CAS 124-38-9
xref: Reference/KEGG Compound C00011
chemical formula: CO2
molecular weight: 43.98983
structure: ChemicalStructure/PW C001316

Reference/KEGG Compound C00075
type: UnificationXref
id: C00075
db: KEGG Compound

Reference/ChEBI CHEBI 18075
type: UnificationXref
id: CHEBI:18075
db: ChEBI

Phosphate
type: SmallMolecule
entity reference: Phosphate

Ubiquinone-1
type: SmallMolecule
entity reference: Ubiquinone-1

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

ChemicalStructure/PW C001189
type: ChemicalStructure
structure format: SMILES

Compound/Generic73/Stoichiometry/1.0
type: Stoichiometry
physical entity: reduced thioredoxin
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

Reference/HMDB HMDB0000295
type: UnificationXref
id: HMDB0000295
db: HMDB

Reference/ChemSpider 5809
type: UnificationXref
id: 5809
db: ChemSpider

Reference/ChemSpider 5808
type: UnificationXref
id: 5808
db: ChemSpider

Reference/BioCyc TMP
type: UnificationXref
id: TMP
db: BioCyc

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/PubChem-compound 6176
type: UnificationXref
id: 6176
db: PubChem-compound

Protein/6612 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ribonucleoside-diphosphate reductase 2 subunit alpha
stoichiometric coefficient: 2.0

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Protein/5822/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ribonucleoside-diphosphate reductase 1 subunit alpha
stoichiometric coefficient: 2.0

L-Aspartic acid
type: SmallMolecule
entity reference: L-Aspartic acid

Phosphoribosyl pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphoribosyl pyrophosphate

L-Aspartic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 44367445
xref: Reference/ChemSpider 5745
xref: Reference/ChEBI CHEBI 17053
xref: Reference/HMDB HMDB0000191
xref: Reference/CAS 56-84-8
xref: Reference/KEGG Compound C00049
xref: Reference/BioCyc L-ASPARTATE
chemical formula: C4H7NO4
molecular weight: 133.0375
structure: ChemicalStructure/PW C000123

Reference/HMDB HMDB0001274
type: UnificationXref
id: HMDB0001274
db: HMDB

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/ChemSpider 5941
type: UnificationXref
id: 5941
db: ChemSpider

Compound/PW C000792/Stoichiometry/1.0
type: Stoichiometry
physical entity: dUDP
stoichiometric coefficient: 1.0

ChemicalStructure/PW C042908
type: ChemicalStructure
structure format: SMILES

Compound/PW C000790 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dCTP
stoichiometric coefficient: 1.0

Compound/PW C000151/Stoichiometry/1.0
type: Stoichiometry
physical entity: Orotic acid
stoichiometric coefficient: 1.0

Protein/6054/Stoichiometry/6.0
type: Stoichiometry
physical entity: Uridylate kinase
stoichiometric coefficient: 6.0

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

ChemicalStructure/PW C000190
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000191
type: UnificationXref
id: HMDB0000191
db: HMDB

ChemicalStructure/PW C000194
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0002012
type: UnificationXref
id: HMDB0002012
db: HMDB

Reference/HMDB HMDB0062623
type: UnificationXref
id: HMDB0062623
db: HMDB

Deoxycytidine triphosphate deaminase
type: Protein
entity reference: Deoxycytidine triphosphate deaminase

ChemicalStructure/PW C000192
type: ChemicalStructure
structure format: SMILES

Ribonucleoside-diphosphate reductase large chain 1
type: Protein
cellular location: Cytosol
entity reference: Ribonucleoside-diphosphate reductase large chain 1

Deoxyuridine 5'-triphosphate nucleotidohydrolase
type: ProteinReference
xref: Reference/UniProt P06968
organism: BiologicalState304

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/HMDB HMDB0041827
type: UnificationXref
id: HMDB0041827
db: HMDB

Reference/BioCyc UMP
type: UnificationXref
id: UMP
db: BioCyc

Compound/PW C000792 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dUDP
stoichiometric coefficient: 1.0

Carbon dioxide
type: SmallMolecule
entity reference: Carbon dioxide

Reference/CAS 56-84-8
type: UnificationXref
id: 56-84-8
db: CAS

Reference/ChemSpider 749
type: UnificationXref
id: 749
db: ChemSpider

Reference/ChemSpider 628
type: UnificationXref
id: 628
db: ChemSpider

Reference/CAS 71-52-3
type: UnificationXref
id: 71-52-3
db: CAS

Compound/PW C001104 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000909
type: UnificationXref
id: PW000909
db: PathWhiz

Hydrogen carbonate
type: SmallMolecule
entity reference: Hydrogen carbonate

Reference/HMDB HMDB0000082
type: UnificationXref
id: HMDB0000082
db: HMDB

Reference/UniProt P06968
type: UnificationXref
id: P06968
db: UniProt

Hydrogen carbonate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000595
xref: Reference/ChEBI CHEBI 17544
xref: Reference/PubChem-compound 769
xref: Reference/BioCyc HCO3
xref: Reference/ChemSpider 749
xref: Reference/CAS 71-52-3
xref: Reference/KEGG Compound C00288
chemical formula: CH2O3
molecular weight: 62.000393
structure: ChemicalStructure/PW C000463

Reference/HMDB HMDB0001056
type: UnificationXref
id: HMDB0001056
db: HMDB

Anaerobic ribonucleoside-triphosphate reductase
type: Protein
entity reference: Anaerobic ribonucleoside-triphosphate reductase

Reference/CAS 2149-82-8
type: UnificationXref
id: 2149-82-8
db: CAS

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

Reference/ChEBI CHEBI 15842
type: UnificationXref
id: CHEBI:15842
db: ChEBI

Reference/HMDB HMDB0000528
type: UnificationXref
id: HMDB0000528
db: HMDB

5,10-methenyltetrahydrofolate mono-L-glutamate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0062623
xref: Reference/ChEBI CHEBI 57455
xref: Reference/PubChem-compound 46878371
chemical formula: C20H20N7O6
molecular weight: 454.14804
structure: ChemicalStructure/PW C042908

N-carbamoyl-L-aspartate
type: SmallMolecule
entity reference: N-carbamoyl-L-aspartate

Ribonucleoside-diphosphate reductase 2 subunit beta
type: Protein
cellular location: Cytosol
entity reference: Ribonucleoside-diphosphate reductase 2 subunit beta

ReactionCatalysis3507
type: Catalysis
controller: dihydroorotase
controlled: 3.5.2.3
control type: ACTIVATION

Cytidine triphosphate
type: SmallMolecule
entity reference: Cytidine triphosphate

ribonucleoside-triphosphate reductase
type: Complex
component stoichiometry: Protein/6481/Stoichiometry/2.0
component: Anaerobic ribonucleoside-triphosphate reductase

ribonucleoside diphosphate reductase 1
type: Complex
component stoichiometry: Protein/6712/Stoichiometry/2.0
component stoichiometry: Protein/6481/Stoichiometry/2.0
component: Ribonucleoside-diphosphate reductase 1 subunit beta
component: Anaerobic ribonucleoside-triphosphate reductase

ReactionCatalysis3508
type: Catalysis
controller: Dihydroorotate dehydrogenase
controlled: 1.3.5.2
control type: ACTIVATION

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

ReactionCatalysis3506
type: Catalysis
controller: aspartate transcarbamylase
controlled: 2.1.3.2
control type: ACTIVATION

nucleoside diphosphate kinase
type: Complex
component stoichiometry: Protein/6034/Stoichiometry/4.0
component: Nucleoside diphosphate kinase

Compound/PW C000790/Stoichiometry/1.0
type: Stoichiometry
physical entity: dCTP
stoichiometric coefficient: 1.0

Protein/5906 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Deoxyuridine 5'-triphosphate nucleotidohydrolase
stoichiometric coefficient: 3.0

Orotic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16742
xref: Reference/HMDB HMDB0000226
xref: Reference/PubChem-compound 967
xref: Reference/BioCyc OROTATE
xref: Reference/KEGG Compound C00295
xref: Reference/CAS 65-86-1
xref: Reference/ChemSpider 942
chemical formula: C5H4N2O4
molecular weight: 156.0171
structure: ChemicalStructure/PW C000151

Compound/PW C001087 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dUMP
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

Protein/6055/Stoichiometry/6.0
type: Stoichiometry
physical entity: Aspartate carbamoyltransferase regulatory chain
stoichiometric coefficient: 6.0

ReactionCatalysis3509
type: Catalysis
controller: orotate phosphoribosyltransferase
controlled: 2.4.2.10
control type: ACTIVATION

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

ReactionCatalysis3514
type: Catalysis
controller: ribonucleoside diphosphate reductase 1
controlled: 1.17.4.1
control type: ACTIVATION

ReactionCatalysis3515
type: Catalysis
controller: nucleoside diphosphate kinase
controlled: Reaction3536
control type: ACTIVATION

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis3512
type: Catalysis
controller: nucleoside diphosphate kinase
controlled: 2.7.4.6
control type: ACTIVATION

ReactionCatalysis3513
type: Catalysis
controller: CTP synthase
controlled: 6.3.4.2
control type: ACTIVATION

orotate phosphoribosyltransferase
type: Complex
component stoichiometry: Protein/6052 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Orotate phosphoribosyltransferase

ReactionCatalysis3518
type: Catalysis
controller: nucleoside triphosphate pyrophosphohydrolase
controlled: 3.6.1.23
control type: ACTIVATION

ReactionCatalysis3519
type: Catalysis
controller: deoxyuridine triphosphatase
controlled: 3.6.1.23
control type: ACTIVATION

ReactionCatalysis3516
type: Catalysis
controller: ribonucleoside diphosphate reductase 1
controlled: Reaction3537
control type: ACTIVATION

ChemicalStructure/PW C000463
type: ChemicalStructure
structure format: SMILES
structure data: OC(O)=O

ribonucleoside-diphosphate reductase 2
type: Complex
component stoichiometry: Protein/6612 Cytosol/Stoichiometry/2.0
component stoichiometry: Protein/6563 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Ribonucleoside-diphosphate reductase 2 subunit alpha
component: Ribonucleoside-diphosphate reductase 2 subunit beta

ReactionCatalysis3517
type: Catalysis
controller: nucleoside diphosphate kinase
controlled: Reaction3538
control type: ACTIVATION

Orotidylic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Orotidylic acid

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

ReactionCatalysis3510
type: Catalysis
controller: orotidine-5'-phosphate decarboxylase
controlled: 4.1.1.23
control type: ACTIVATION

Protein/6712/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ribonucleoside-diphosphate reductase 1 subunit beta
stoichiometric coefficient: 2.0

ReactionCatalysis3511
type: Catalysis
controller: UMP kinase
controlled: 2.7.4.22
control type: ACTIVATION

carbamoyl phosphate synthetase
type: Complex
component stoichiometry: Protein/5989/Stoichiometry/2.0
component stoichiometry: Protein/5860/Stoichiometry/2.0
component: Carbamoyl-phosphate synthase large chain
component: Carbamoyl-phosphate synthase small chain

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

ChemicalStructure/PW C000792
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis3525
type: Catalysis
controller: ribonucleoside-diphosphate reductase 2
controlled: Reaction3544
control type: ACTIVATION

Aspartate carbamoyltransferase catalytic chain
type: Protein
entity reference: Aspartate carbamoyltransferase catalytic chain

Orotic acid
type: SmallMolecule
entity reference: Orotic acid

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

ReactionCatalysis3523
type: Catalysis
controller: ribonucleoside-triphosphate reductase
controlled: Reaction3542
control type: ACTIVATION

ChemicalStructure/PW C000790
type: ChemicalStructure
structure format: SMILES

Nucleoside diphosphate kinase
type: Protein
entity reference: Nucleoside diphosphate kinase

ReactionCatalysis3524
type: Catalysis
controller: ribonucleoside-triphosphate reductase
controlled: Reaction3543
control type: ACTIVATION

Reference/UniProt P49723
type: UnificationXref
id: P49723
db: UniProt

ReactionCatalysis3527
type: Catalysis
controller: dCTP deaminase
controlled: 3.5.4.13
control type: ACTIVATION

Reference/ChemSpider 274
type: UnificationXref
id: 274
db: ChemSpider

Reference/ChemSpider 272
type: UnificationXref
id: 272
db: ChemSpider

Reference/CAS 155-54-4
type: UnificationXref
id: 155-54-4
db: CAS

Reference/CAS 4208-67-7
type: UnificationXref
id: 4208-67-7
db: CAS

ReactionCatalysis2670
type: Catalysis
controller: carbamoyl phosphate synthetase
controlled: 6.3.5.5
control type: ACTIVATION

Reference/BioCyc DUMP
type: UnificationXref
id: DUMP
db: BioCyc

ReactionCatalysis3521
type: Catalysis
controller: Thymidylate synthase
controlled: 2.1.1.45
control type: ACTIVATION

ReactionCatalysis3522
type: Catalysis
controller: nucleoside diphosphate kinase
controlled: Reaction3541
control type: ACTIVATION

Compound/PW C000151 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Orotic acid
stoichiometric coefficient: 1.0

ReactionCatalysis3520
type: Catalysis
controller: Nucleoside triphosphatase nudI
controlled: 3.6.1.23
control type: ACTIVATION

Reference/ChemSpider 141140
type: UnificationXref
id: 141140
db: ChemSpider

Orotidine 5'-phosphate decarboxylase
type: ProteinReference
xref: Reference/UniProt P08244

Compound/PW C000144 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Orotidylic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15713
type: UnificationXref
id: CHEBI:15713
db: ChEBI

Ribonucleoside-diphosphate reductase 1 subunit alpha
type: ProteinReference
xref: Reference/UniProt P00452

Reference/PubChem-compound 164628
type: UnificationXref
id: 164628
db: PubChem-compound

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

nucleoside diphosphate kinase
type: Complex
component stoichiometry: Protein/6034 Cytosol/Stoichiometry/4.0
cellular location: Cytosol
component: Nucleoside diphosphate kinase

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

N-carbamoyl-L-aspartate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 32814
xref: Reference/PubChem-compound 21960964
chemical formula: C5H6N2O5
molecular weight: 174.02876
structure: ChemicalStructure/PW C042935

Ubiquinone-1
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16389
xref: Reference/ChemSpider 4307
xref: Reference/PubChem-compound 4462
xref: Reference/CAS 727-81-1
xref: Reference/HMDB HMDB0002012
xref: Reference/KEGG Compound C00399
chemical formula: C14H18O4
molecular weight: 250.12051
structure: ChemicalStructure/PW C001347

Ubiquinol-1
type: SmallMolecule
entity reference: Ubiquinol-1

Reference/HMDB HMDB0001409
type: UnificationXref
id: HMDB0001409
db: HMDB

Compound/PW C000414/Stoichiometry/2.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 2.0

Orotidylic acid
type: SmallMolecule
entity reference: Orotidylic acid

ChemicalStructure/PW C000201
type: ChemicalStructure
structure format: SMILES

Orotidylic acid
type: SmallMoleculeReference
xref: Reference/CAS 2149-82-8
xref: Reference/BioCyc OROTIDINE-5-PHOSPHATE
xref: Reference/PubChem-compound 160617
xref: Reference/ChemSpider 141140
xref: Reference/ChEBI CHEBI 15842
xref: Reference/HMDB HMDB0000218
xref: Reference/KEGG Compound C01103
chemical formula: C10H13N2O11P
molecular weight: 368.0257
structure: ChemicalStructure/PW C000144

Compound/PW C000987/Stoichiometry/1.0
type: Stoichiometry
physical entity: dTDP
stoichiometric coefficient: 1.0

Reference/PathWhiz PW000942
type: UnificationXref
id: PW000942
db: PathWhiz

Reference/CAS 2056-98-6
type: UnificationXref
id: 2056-98-6
db: CAS

Reference/ChemSpider 144320
type: UnificationXref
id: 144320
db: ChemSpider

oxidized thioredoxin
type: SmallMolecule
entity reference: oxidized thioredoxin

reduced thioredoxin
type: SmallMolecule
entity reference: reduced thioredoxin

Ribonucleoside-diphosphate reductase small chain 2
type: Protein
cellular location: Cytosol
entity reference: Ribonucleoside-diphosphate reductase small chain 2

Reference/ChemSpider 218
type: UnificationXref
id: 218
db: ChemSpider

Uridine triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6133
xref: Reference/CAS 63-39-8
xref: Reference/ChemSpider 5903
xref: Reference/ChEBI CHEBI 15713
xref: Reference/KEGG Compound C00075
xref: Reference/HMDB HMDB0000285
xref: Reference/BioCyc UTP
chemical formula: C9H15N2O15P3
molecular weight: 483.96854
structure: ChemicalStructure/PW C000192

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

Aspartate carbamoyltransferase regulatory chain
type: Protein
entity reference: Aspartate carbamoyltransferase regulatory chain

CDP
type: SmallMolecule
entity reference: CDP

Phosphoribosyl pyrophosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00119
xref: Reference/ChemSpider 7062
xref: Reference/CAS 7540-64-9
xref: Reference/HMDB HMDB0000280
xref: Reference/PubChem-compound 7339
xref: Reference/BioCyc PRPP
xref: Reference/ChEBI CHEBI 17111
chemical formula: C5H13O14P3
molecular weight: 389.9518
structure: ChemicalStructure/PW C000190

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Reference/HMDB HMDB0001546
type: UnificationXref
id: HMDB0001546
db: HMDB

Reference/ChEBI CHEBI 28846
type: UnificationXref
id: CHEBI:28846
db: ChEBI

Compound/PW C000057/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 124-38-9
type: UnificationXref
id: 124-38-9
db: CAS

CTP synthase
type: Protein
entity reference: CTP synthase

Uridylate kinase
type: Protein
entity reference: Uridylate kinase

dUMP
type: SmallMolecule
cellular location: Cytosol
entity reference: dUMP

Dihydroorotate dehydrogenase
type: Protein
entity reference: Dihydroorotate dehydrogenase

Uridine 5'-monophosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000288
xref: Reference/CAS 58-97-9
xref: Reference/KEGG Compound C00105
xref: Reference/PubChem-compound 6030
xref: Reference/BioCyc UMP
xref: Reference/ChEBI CHEBI 16695
xref: Reference/ChemSpider 5808
chemical formula: C9H13N2O9P
molecular weight: 324.03586
structure: ChemicalStructure/PW C000194

Compound/PW C000962 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: dCDP
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16742
type: UnificationXref
id: CHEBI:16742
db: ChEBI

Reference/ChemSpider 9319
type: UnificationXref
id: 9319
db: ChemSpider

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/HMDB HMDB0000218
type: UnificationXref
id: HMDB0000218
db: HMDB

CTP synthase
type: Complex
component stoichiometry: Protein/6053/Stoichiometry/4.0
component: CTP synthase

a reduced NrdH glutaredoxin-like protein
type: SmallMoleculeReference

Protein/6563 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Ribonucleoside-diphosphate reductase 2 subunit beta
stoichiometric coefficient: 2.0

ChemicalStructure/PW C001347
type: ChemicalStructure
structure format: SMILES
structure data: COC1=C(OC)C(=O)C(CC=C(C)C)=C(C)C1=O

an oxidized flavodoxin
type: SmallMoleculeReference

Reference/ChEBI CHEBI 57455
type: UnificationXref
id: CHEBI:57455
db: ChEBI

an oxidized NrdH glutaredoxin-like protein
type: SmallMoleculeReference

a reduced flavodoxin
type: SmallMoleculeReference

aspartate transcarbamylase
type: Complex
component stoichiometry: Protein/6055/Stoichiometry/6.0
component stoichiometry: Protein/6036/Stoichiometry/6.0
component: Aspartate carbamoyltransferase catalytic chain
component: Aspartate carbamoyltransferase regulatory chain

dihydroorotase
type: Complex
component stoichiometry: Protein/5878/Stoichiometry/2.0
component: Dihydroorotase

an oxidized NrdH glutaredoxin-like protein
type: SmallMolecule
cellular location: Cytosol
entity reference: an oxidized NrdH glutaredoxin-like protein

Reference/HMDB HMDB0000226
type: UnificationXref
id: HMDB0000226
db: HMDB

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

ChemicalStructure/PW C000144
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/BioCyc CDP
type: UnificationXref
id: CDP
db: BioCyc

Reference/UniProt P0A6F1
type: UnificationXref
id: P0A6F1
db: UniProt

orotidine-5'-phosphate decarboxylase
type: Complex
component stoichiometry: Protein/5946/Stoichiometry/2.0
component: Orotidine 5'-phosphate decarboxylase

UMP kinase
type: Complex
component stoichiometry: Protein/6054/Stoichiometry/6.0
component: Uridylate kinase

an oxidized flavodoxin
type: SmallMolecule
entity reference: an oxidized flavodoxin

Compound/PW C000123/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Aspartic acid
stoichiometric coefficient: 1.0

a reduced flavodoxin
type: SmallMolecule
entity reference: a reduced flavodoxin

Ribonucleoside-diphosphate reductase 1
type: Complex
component stoichiometry: Protein/10848 Cytosol/Stoichiometry/1.0
component stoichiometry: Protein/10849 Cytosol/Stoichiometry/1.0
cellular location: Cytosol
component: Ribonucleoside-diphosphate reductase small chain 2
component: Ribonucleoside-diphosphate reductase large chain 1

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/UniProt P00452
type: UnificationXref
id: P00452
db: UniProt

ChemicalStructure/PW C001316
type: ChemicalStructure
structure format: SMILES
structure data: O=C=O

Reference/ChEBI CHEBI 28938
type: UnificationXref
id: CHEBI:28938
db: ChEBI

Reference/BioCyc TDP
type: UnificationXref
id: TDP
db: BioCyc

Reference/HMDB HMDB0000595
type: UnificationXref
id: HMDB0000595
db: HMDB

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

Uridine 5'-monophosphate
type: SmallMolecule
entity reference: Uridine 5'-monophosphate

dCTP deaminase
type: Complex
component stoichiometry: Protein/6472/Stoichiometry/3.0
component: Deoxycytidine triphosphate deaminase

Thymidylate synthase
type: Protein
entity reference: Thymidylate synthase

5,10-methenyltetrahydrofolate mono-L-glutamate
type: SmallMolecule
entity reference: 5,10-methenyltetrahydrofolate mono-L-glutamate

ribonucleoside diphosphate reductase 1
type: Complex
component stoichiometry: Protein/5822/Stoichiometry/2.0
component stoichiometry: Protein/6712/Stoichiometry/2.0
component: Ribonucleoside-diphosphate reductase 1 subunit beta
component: Ribonucleoside-diphosphate reductase 1 subunit alpha

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Cytidine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17677
xref: Reference/CAS 65-47-4
xref: Reference/PubChem-compound 6176
xref: Reference/KEGG Compound C00063
xref: Reference/ChemSpider 5941
xref: Reference/HMDB HMDB0000082
xref: Reference/BioCyc CTP
chemical formula: C9H16N3O14P3
molecular weight: 482.9845
structure: ChemicalStructure/PW C000057

Compound/PW C000831/Stoichiometry/1.0
type: Stoichiometry
physical entity: Dihydrofolic acid
stoichiometric coefficient: 1.0

Uridine triphosphate
type: SmallMolecule
entity reference: Uridine triphosphate

Reference/UniProt P28903
type: UnificationXref
id: P28903
db: UniProt

Phosphoribosyl pyrophosphate
type: SmallMolecule
entity reference: Phosphoribosyl pyrophosphate
name: SubPathwayOutput

Carbamoyl-phosphate synthase small chain
type: ProteinReference
xref: Reference/UniProt P0A6F1

Reference/KEGG Compound C00705
type: UnificationXref
id: C00705
db: KEGG Compound

Reference/ChEBI CHEBI 15633
type: UnificationXref
id: CHEBI:15633
db: ChEBI

Ribonucleoside-diphosphate reductase 1 subunit beta
type: ProteinReference
xref: Reference/UniProt P69924

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: Reference/UniProt P00968

reduced thioredoxin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15033

Protein/6481/Stoichiometry/2.0
type: Stoichiometry
physical entity: Anaerobic ribonucleoside-triphosphate reductase
stoichiometric coefficient: 2.0

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Thymidine 5'-triphosphate
type: SmallMolecule
entity reference: Thymidine 5'-triphosphate

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Thymidine 5'-triphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00459
xref: Reference/CAS 365-08-2
xref: Reference/ChEBI CHEBI 18077
xref: Reference/ChemSpider 58493
xref: Reference/PubChem-compound 64968
xref: Reference/HMDB HMDB0001342
xref: Reference/BioCyc TTP
chemical formula: C10H17N2O14P3
molecular weight: 481.98926
structure: ChemicalStructure/PW C001035

ChemicalStructure/PW C000123
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CC(O)=O)C(O)=O

Protein/6053/Stoichiometry/4.0
type: Stoichiometry
physical entity: CTP synthase
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 17622
type: UnificationXref
id: CHEBI:17622
db: ChEBI

Reference/BioCyc OROTIDINE-5-PHOSPHATE
type: UnificationXref
id: OROTIDINE-5-PHOSPHATE
db: BioCyc

Compound/PW C000194/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-monophosphate
stoichiometric coefficient: 1.0

Dihydroorotase
type: ProteinReference
xref: Reference/UniProt P05020

Reference/ChEBI CHEBI 17625
type: UnificationXref
id: CHEBI:17625
db: ChEBI

nucleoside triphosphate pyrophosphohydrolase
type: Complex
component stoichiometry: Protein/6257 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Protein mazG

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

ChemicalStructure/PW C000962
type: ChemicalStructure
structure format: SMILES

Compound/PW C000950/Stoichiometry/1.0
type: Stoichiometry
physical entity: 5-Thymidylic acid
stoichiometric coefficient: 1.0

Reference/BioCyc UDP
type: UnificationXref
id: UDP
db: BioCyc

oxidized thioredoxin
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15033

dUMP
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17622
xref: Reference/ChemSpider 58574
xref: Reference/HMDB HMDB0001409
xref: Reference/CAS 964-26-1
xref: Reference/BioCyc DUMP
xref: Reference/PubChem-compound 65063
xref: Reference/KEGG Compound C00365
chemical formula: C9H13N2O8P
molecular weight: 308.04095
structure: ChemicalStructure/PW C001087

Reference/PubChem-compound 150855
type: UnificationXref
id: 150855
db: PubChem-compound

Ribonucleoside-diphosphate reductase 2 subunit alpha
type: Protein
cellular location: Cytosol
entity reference: Ribonucleoside-diphosphate reductase 2 subunit alpha

Reference/BioCyc DCTP
type: UnificationXref
id: DCTP
db: BioCyc

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Nucleoside diphosphate kinase
type: Protein
cellular location: Cytosol
entity reference: Nucleoside diphosphate kinase

Reference/BioCyc CARBAMOYL-P
type: UnificationXref
id: CARBAMOYL-P
db: BioCyc

Reference/UniProt P08244
type: UnificationXref
id: P08244
db: UniProt

Orotate phosphoribosyltransferase
type: Protein
cellular location: Cytosol
entity reference: Orotate phosphoribosyltransferase

Ribonucleoside-diphosphate reductase 2 subunit alpha
type: ProteinReference
xref: Reference/UniProt P39452
organism: BiologicalState304

Reference/PubChem-compound 65063
type: UnificationXref
id: 65063
db: PubChem-compound

Compound/PW C001189/Stoichiometry/1.0
type: Stoichiometry
physical entity: CDP
stoichiometric coefficient: 1.0

Reference/PubChem-compound 65070
type: UnificationXref
id: 65070
db: PubChem-compound

ChemicalStructure/PW C000862
type: ChemicalStructure
structure format: SMILES
structure data: NC(=O)OP(O)(O)=O

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

Reference/CAS 14798-03-9
type: UnificationXref
id: 14798-03-9
db: CAS

Reference/UniProt P0A7E1
type: UnificationXref
id: P0A7E1
db: UniProt

Reference/UniProt P0A7E3
type: UnificationXref
id: P0A7E3
db: UniProt

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Compound/Generic97/Stoichiometry/1.0
type: Stoichiometry
physical entity: a reduced flavodoxin
stoichiometric coefficient: 1.0

Reference/UniProt P0A7E5
type: UnificationXref
id: P0A7E5
db: UniProt

Reference/UniProt P0A7E9
type: UnificationXref
id: P0A7E9
db: UniProt

Escherichia coli
type: BioSource
xref: Reference/TAXONOMY 562

CDP
type: SmallMolecule
cellular location: Cytosol
entity reference: CDP

Compound/PW C000406/Stoichiometry/1.0
type: Stoichiometry
physical entity: 4,5-Dihydroorotic acid
stoichiometric coefficient: 1.0

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Compound/PW C001316/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carbon dioxide
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000950
type: ChemicalStructure
structure format: SMILES

CDP
type: SmallMoleculeReference
xref: Reference/ChemSpider 5902
xref: Reference/PubChem-compound 6132
xref: Reference/HMDB HMDB0001546
xref: Reference/ChEBI CHEBI 17239
xref: Reference/BioCyc CDP
xref: Reference/CAS 63-38-7
xref: Reference/KEGG Compound C00112
chemical formula: C9H15N3O11P2
molecular weight: 403.0182
structure: ChemicalStructure/PW C001189

dUMP
type: SmallMolecule
entity reference: dUMP

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Reference/UniProt P0A7F3
type: UnificationXref
id: P0A7F3
db: UniProt

ChemicalStructure/PW C022608
type: ChemicalStructure
structure format: SMILES
structure data: [NH4+]

Reference/PubChem-compound 9700
type: UnificationXref
id: 9700
db: PubChem-compound

Reference/PathWhiz PW001886
type: UnificationXref
id: PW001886
db: PathWhiz

Reference/ChEBI CHEBI 16526
type: UnificationXref
id: CHEBI:16526
db: ChEBI

ChemicalStructure/PW C000831
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Reference/PubChem-compound 65091
type: UnificationXref
id: 65091
db: PubChem-compound

Reference/BioCyc DUTP
type: UnificationXref
id: DUTP
db: BioCyc

Reference/CAS 1173-82-6
type: UnificationXref
id: 1173-82-6
db: CAS

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Protein/6052 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Orotate phosphoribosyltransferase
stoichiometric coefficient: 2.0

a reduced NrdH glutaredoxin-like protein
type: SmallMolecule
cellular location: Cytosol
entity reference: a reduced NrdH glutaredoxin-like protein

Reference/ChEBI CHEBI 28850
type: UnificationXref
id: CHEBI:28850
db: ChEBI

Reference/ChEBI CHEBI 17544
type: UnificationXref
id: CHEBI:17544
db: ChEBI

Protein/6472/Stoichiometry/3.0
type: Stoichiometry
physical entity: Deoxycytidine triphosphate deaminase
stoichiometric coefficient: 3.0

dCTP
type: SmallMolecule
cellular location: Cytosol
entity reference: dCTP

Protein/5989/Stoichiometry/2.0
type: Stoichiometry
physical entity: Carbamoyl-phosphate synthase small chain
stoichiometric coefficient: 2.0

Ubiquinol-1
type: SmallMoleculeReference
xref: Reference/PubChem-compound 447920
chemical formula: C14H20O4
molecular weight: 252.13615
structure: ChemicalStructure/PW C042948

Protein mazG
type: Protein
cellular location: Cytosol
entity reference: Protein mazG

Deoxyuridine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Deoxyuridine triphosphate

Nucleoside triphosphatase nudI
type: ProteinReference
xref: Reference/UniProt P52006
organism: BiologicalState304

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000406
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C1CC(=O)NC(=O)N1

Reference/ChEBI CHEBI 16695
type: UnificationXref
id: CHEBI:16695
db: ChEBI

Reference/ChEBI CHEBI 32814
type: UnificationXref
id: CHEBI:32814
db: ChEBI

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 17677
type: UnificationXref
id: CHEBI:17677
db: ChEBI

Deoxyuridine triphosphate
type: SmallMolecule
entity reference: Deoxyuridine triphosphate

Reference/PubChem-compound 278
type: UnificationXref
id: 278
db: PubChem-compound

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 17672
type: UnificationXref
id: CHEBI:17672
db: ChEBI

Phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Phosphate

Reference/UniProt P00968
type: UnificationXref
id: P00968
db: UniProt

Compound/PW C022608/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ammonium
stoichiometric coefficient: 1.0

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/UniProt P21524
type: UnificationXref
id: P21524
db: UniProt

Reference/PubChem-compound 280
type: UnificationXref
id: 280
db: PubChem-compound

Reference/ChEBI CHEBI 30865
type: UnificationXref
id: CHEBI:30865
db: ChEBI

Compound/PW C001087/Stoichiometry/1.0
type: Stoichiometry
physical entity: dUMP
stoichiometric coefficient: 1.0

Reference/CAS 491-97-4
type: UnificationXref
id: 491-97-4
db: CAS

Reference/ChEBI CHEBI 16311
type: UnificationXref
id: CHEBI:16311
db: ChEBI

Reference/KEGG Compound C00415
type: UnificationXref
id: C00415
db: KEGG Compound

Reference/PubChem-compound 4462
type: UnificationXref
id: 4462
db: PubChem-compound

Reference/TAXONOMY 2
type: UnificationXref
id: 2
db: TAXONOMY

Reference/ChemSpider 58601
type: UnificationXref
id: 58601
db: ChemSpider

Reference/PubChem-compound 16741146
type: UnificationXref
id: 16741146
db: PubChem-compound

ChemicalStructure/PW C000987
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 89228
type: UnificationXref
id: 89228
db: ChemSpider

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Ribonucleoside-diphosphate reductase 1 subunit alpha
type: Protein
entity reference: Ribonucleoside-diphosphate reductase 1 subunit alpha

Orotidine 5'-phosphate decarboxylase
type: Protein
entity reference: Orotidine 5'-phosphate decarboxylase

Reference/BioCyc PRPP
type: UnificationXref
id: PRPP
db: BioCyc

2.7.4.22
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000194/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Uridine 5'-diphosphate
spontaneous: false
EC number: 2.7.4.22
left: Uridine 5'-monophosphate
left: Adenosine triphosphate
name: Adenosine triphosphate + Uridine 5'-monophosphate → Adenosine diphosphate + Uridine 5'-diphosphate
conversion direction: LEFT_TO_RIGHT

4.1.1.23
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001316/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000194/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000144/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Uridine 5'-monophosphate
right: Carbon dioxide
spontaneous: false
EC number: 4.1.1.23
left: Orotidylic acid
left: Hydrogen Ion
name: Hydrogen Ion + Orotidylic acid → Carbon dioxide + Uridine 5'-monophosphate
conversion direction: LEFT_TO_RIGHT

Reference/CAS 727-81-1
type: UnificationXref
id: 727-81-1
db: CAS

Reference/HMDB HMDB0000998
type: UnificationXref
id: HMDB0000998
db: HMDB

Orotic acid
type: SmallMolecule
cellular location: Cytosol
entity reference: Orotic acid

3.6.1.23
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001087 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000927 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Cytosol/Stoichiometry/1.0
right: Phosphate
right: Hydrogen Ion
right: dUMP
spontaneous: false
EC number: 3.6.1.23
left: Deoxyuridine triphosphate
left: Water
name: Deoxyuridine triphosphate + Water → Hydrogen Ion + Phosphate + dUMP
conversion direction: LEFT_TO_RIGHT

Reaction3538
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000792 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000927 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: Deoxyuridine triphosphate
spontaneous: false
left: Adenosine triphosphate
left: dUDP
name: Adenosine triphosphate + dUDP → Adenosine diphosphate + Deoxyuridine triphosphate
conversion direction: LEFT_TO_RIGHT

Reaction3537
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000792/Stoichiometry/1.0
participant stoichiometry: Compound/Generic73/Stoichiometry/1.0
participant stoichiometry: Compound/Generic72/Stoichiometry/1.0
right: oxidized thioredoxin
right: Water
right: dUDP
spontaneous: false
left: reduced thioredoxin
left: Uridine 5'-diphosphate
name: Uridine 5'-diphosphate + reduced thioredoxin ? Water + dUDP + oxidized thioredoxin

Reaction3536
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000962 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000790 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: Adenosine diphosphate
right: dCTP
spontaneous: false
left: Adenosine triphosphate
left: dCDP
name: Adenosine triphosphate + dCDP → Adenosine diphosphate + dCTP
conversion direction: LEFT_TO_RIGHT

1.17.4.1
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000962/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/Generic73/Stoichiometry/1.0
participant stoichiometry: Compound/Generic72/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001189/Stoichiometry/1.0
right: Water
right: oxidized thioredoxin
right: dCDP
spontaneous: false
EC number: 1.17.4.1
left: CDP
left: reduced thioredoxin
name: CDP + reduced thioredoxin → Water + dCDP + oxidized thioredoxin
conversion direction: LEFT_TO_RIGHT

ReactionCatalysis6712
type: Catalysis
controller: Ribonucleoside-diphosphate reductase 1
controlled: Reaction6749
control type: ACTIVATION

Reaction3534
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001189/Stoichiometry/1.0
right: CDP
right: Hydrogen Ion
right: Phosphate
spontaneous: false
left: Water
left: Cytidine triphosphate
name: Cytidine triphosphate + Water → CDP + Hydrogen Ion + Phosphate
conversion direction: LEFT_TO_RIGHT

6.3.4.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000192/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: Adenosine diphosphate
right: L-Glutamic acid
right: Cytidine triphosphate
right: Hydrogen Ion
right: Phosphate
spontaneous: false
EC number: 6.3.4.2
left: Water
left: L-Glutamine
left: Uridine triphosphate
left: Adenosine triphosphate
name: Adenosine triphosphate + L-Glutamine + Uridine triphosphate + Water → Adenosine diphosphate + Cytidine triphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate
conversion direction: LEFT_TO_RIGHT

Compound/PW C040034/Stoichiometry/2.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 2.0

2.7.4.6
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000201/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000192/Stoichiometry/1.0
right: Adenosine diphosphate
right: Uridine triphosphate
spontaneous: false
EC number: 2.7.4.6
left: Uridine 5'-diphosphate
left: Adenosine triphosphate
name: Adenosine triphosphate + Uridine 5'-diphosphate → Adenosine diphosphate + Uridine triphosphate
conversion direction: LEFT_TO_RIGHT

Compound/Generic96/Stoichiometry/1.0
type: Stoichiometry
physical entity: an oxidized flavodoxin
stoichiometric coefficient: 1.0

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/CAS 63-39-8
type: UnificationXref
id: 63-39-8
db: CAS

Reference/ChEBI CHEBI 17659
type: UnificationXref
id: CHEBI:17659
db: ChEBI

2.4.2.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000190 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000144 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000151 Cytosol/Stoichiometry/1.0
right: Pyrophosphate
right: Orotidylic acid
spontaneous: false
EC number: 2.4.2.10
left: Phosphoribosyl pyrophosphate
left: Orotic acid
name: Orotic acid + Phosphoribosyl pyrophosphate → Orotidylic acid + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001967
type: UnificationXref
id: HMDB0001967
db: HMDB

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Reference/UniProt P69924
type: UnificationXref
id: P69924
db: UniProt

1.3.5.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001347/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000151/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000406/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042948/Stoichiometry/1.0
right: Orotic acid
right: Ubiquinol-1
spontaneous: false
EC number: 1.3.5.2
left: 4,5-Dihydroorotic acid
left: Ubiquinone-1
name: 4,5-Dihydroorotic acid + Ubiquinone-1 → Orotic acid + Ubiquinol-1
conversion direction: LEFT_TO_RIGHT

3.5.2.3
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042935/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000406/Stoichiometry/1.0
right: Water
right: 4,5-Dihydroorotic acid
spontaneous: false
EC number: 3.5.2.3
left: Hydrogen Ion
left: N-carbamoyl-L-aspartate
name: N-carbamoyl-L-aspartate + Hydrogen Ion → 4,5-Dihydroorotic acid + Water
conversion direction: LEFT_TO_RIGHT

2.1.3.2
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000123/Stoichiometry/1.0
participant stoichiometry: Compound/PW C042935/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000862/Stoichiometry/1.0
right: Hydrogen Ion
right: Phosphate
right: N-carbamoyl-L-aspartate
spontaneous: false
EC number: 2.1.3.2
left: L-Aspartic acid
left: Carbamoyl phosphate
name: Carbamoyl phosphate + L-Aspartic acid → N-carbamoyl-L-aspartate + Hydrogen Ion + Phosphate
conversion direction: LEFT_TO_RIGHT

6.3.5.5
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000463/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/2.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000862/Stoichiometry/1.0
right: Adenosine diphosphate
right: L-Glutamic acid
right: Hydrogen Ion
right: Carbamoyl phosphate
right: Phosphate
spontaneous: false
EC number: 6.3.5.5
left: Water
left: Hydrogen carbonate
left: L-Glutamine
left: Adenosine triphosphate
name: 2 Adenosine triphosphate + Hydrogen carbonate + L-Glutamine + Water → 2 Adenosine diphosphate + Carbamoyl phosphate + 2 Hydrogen Ion + L-Glutamic acid + Phosphate
conversion direction: LEFT_TO_RIGHT