Reference/KEGG Compound C00318
type: UnificationXref
id: C00318
db: KEGG Compound

Crotonobetainyl-CoA:carnitine CoA-transferase
type: Protein
cellular location: Cytosol
entity reference: Crotonobetainyl-CoA:carnitine CoA-transferase

L-carnitine dehydratase
type: Dna
cellular location: Cytosol
entity reference: L-carnitine dehydratase

direct_interaction
type: InteractionVocabulary

Reference/TAXONOMY 83333
type: UnificationXref
id: 83333
db: TAXONOMY

Protein/6507/Stoichiometry/2.0
type: Stoichiometry
physical entity: Crotonobetainyl-CoA:carnitine CoA-transferase
stoichiometric coefficient: 2.0

L-Carnitine
type: SmallMolecule
cellular location: Extracellular Space
entity reference: L-Carnitine

Aerobic respiration control protein ArcA
type: ProteinReference
xref: Reference/UniProt P0A9Q1
organism: Escherichia coli

Reference/HMDB HMDB0003364
type: UnificationXref
id: HMDB0003364
db: HMDB

carnitine operon protein CaiE
type: Protein
cellular location: Cytosol
entity reference: carnitine operon protein CaiE

Aerobic respiration control sensor protein ArcB
type: Protein
cellular location: Cell Membrane
entity reference: Aerobic respiration control sensor protein ArcB

terminator
type: DnaReference
organism: Escherichia coli

carnitine operon protein CaiE
type: Dna
cellular location: Cytosol
entity reference: carnitine operon protein CaiE

L-Carnitine
type: SmallMoleculeReference
xref: Reference/BioCyc CARNITINE
xref: Reference/ChEBI CHEBI 16347
xref: Reference/PubChem-compound 10917
xref: Reference/CAS 541-15-1
xref: Reference/KEGG Compound C00318
xref: Reference/HMDB HMDB0000062
xref: Reference/ChemSpider 10455
chemical formula: C7H15NO3
molecular weight: 161.1052
structure: ChemicalStructure/PW C000044

DNA/86 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-carnitine dehydratase
stoichiometric coefficient: 1.0

carnitine operon protein CaiE
type: ProteinReference
xref: Reference/UniProt P39206
organism: Escherichia coli

cAMP
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6076
xref: Reference/HMDB HMDB0000058
xref: Reference/ChEBI CHEBI 17489
xref: Reference/CAS 60-92-4
xref: Reference/BioCyc CAMP
xref: Reference/ChemSpider 5851
xref: Reference/KEGG Compound C00575
chemical formula: C10H12N5O6P
molecular weight: 329.05252
structure: ChemicalStructure/PW C000041

Reference/UniProt P31553
type: UnificationXref
id: P31553
db: UniProt

Reference/UniProt P31552
type: UnificationXref
id: P31552
db: UniProt

Reference/UniProt P31551
type: UnificationXref
id: P31551
db: UniProt

Compound/PW C000041 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Promoter
type: DnaReference
organism: Escherichia coli

Reference/KEGG Compound C00575
type: UnificationXref
id: C00575
db: KEGG Compound

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Reference/UniProt P0A9Q1
type: UnificationXref
id: P0A9Q1
db: UniProt

cAMP-activated global transcriptional regulator CRP
type: Complex
component stoichiometry: Protein/10248 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: cAMP-activated global transcriptional regulator CRP

DNA-directed RNA polymerase subunit beta
type: Protein
cellular location: Cytoplasm
entity reference: DNA-directed RNA polymerase subunit beta

Reference/SMPDB SMP0001889
type: UnificationXref
id: SMP0001889
db: SMPDB

Interaction8086
type: MolecularInteraction
interaction type: direct_interaction
name: Transcriptional activatory protein CaiF activates Promoter
participant: Transcriptional activatory protein CaiF
participant: Promoter

Interaction8084
type: MolecularInteraction
interaction type: direct_interaction
name: Quinone activates ArcB
participant: ArcB
participant: Quinone

Interaction8085
type: MolecularInteraction
interaction type: direct_interaction
name: ArcB activates ArcA
participant: ArcB
participant: Aerobic respiration control protein ArcA

DNA/89 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: carnitine operon protein CaiE
stoichiometric coefficient: 1.0

Reference/ChemSpider 5851
type: UnificationXref
id: 5851
db: ChemSpider

Reference/PubChem-compound 4650
type: UnificationXref
id: 4650
db: PubChem-compound

ProteinComplex/3804 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: cAMP-activated global transcriptional regulator CRP
stoichiometric coefficient: 2.0

Transcriptional activatory protein CaiF
type: Protein
cellular location: Cytoplasm
entity reference: Transcriptional activatory protein CaiF

Probable crotonobetaine/carnitine-CoA ligase
type: Protein
entity reference: Probable crotonobetaine/carnitine-CoA ligase
name: SubPathwayInput

Reference/SMPDB SMP0002051
type: UnificationXref
id: SMP0002051
db: SMPDB

ProteinComplex/4010 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: γ-butyrobetainyl-CoA:carnitine CoA transferase
stoichiometric coefficient: 1.0

L-carnitine/gamma-butyrobetaine antiporter
type: Protein
entity reference: L-carnitine/gamma-butyrobetaine antiporter

terminator
type: Dna
cellular location: Cytosol
entity reference: terminator

CRP-cAMP DNA-binding transcriptional dual regulator
type: Complex
component stoichiometry: Protein/10248 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: cAMP-activated global transcriptional regulator CRP

Reference/PathWhiz PW001875
type: UnificationXref
id: PW001875
db: PathWhiz

RNA polymerase sigma 70
type: Complex
component stoichiometry: Protein/6061 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: DNA-directed RNA polymerase subunit beta
component: RNA polymerase, sigma 70 (sigma D) factor
component: DNA-directed RNA polymerase subunit beta'
component: DNA-directed RNA polymerase subunit alpha

L-carnitine/gamma-butyrobetaine antiporter
type: Protein
cellular location: Cell Membrane
entity reference: L-carnitine/gamma-butyrobetaine antiporter

carnitine racemase
type: Dna
cellular location: Cytosol
entity reference: carnitine racemase

DNA/143 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: terminator
stoichiometric coefficient: 1.0

Reference/CAS 541-15-1
type: UnificationXref
id: 541-15-1
db: CAS

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Reference/KEGG Compound C00472
type: UnificationXref
id: C00472
db: KEGG Compound

Aerobic respiration control sensor protein ArcB
type: ProteinReference
xref: Reference/UniProt P0AEC3
organism: BiologicalState1078

DNA/559 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: caiF
stoichiometric coefficient: 1.0

Reaction1034480
type: BiochemicalReaction
participant stoichiometry: DNA/559 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: DNA/47 Cytoplasm/Stoichiometry/1.0
right: caiF
spontaneous: true
left: Promoter
name: Promoter → caiF
conversion direction: LEFT_TO_RIGHT

Reference/GENE ONTOLOGY GO 0005886
type: UnificationXref
id: GO:0005886
db: GENE ONTOLOGY

DNA-directed RNA polymerase subunit alpha
type: Protein
cellular location: Cytoplasm
entity reference: DNA-directed RNA polymerase subunit alpha

Reference/UniProt P39206
type: UnificationXref
id: P39206
db: UniProt

Reference/PathWhiz PW002037
type: UnificationXref
id: PW002037
db: PathWhiz

Carnitinyl-CoA dehydratase
type: Protein
entity reference: Carnitinyl-CoA dehydratase
name: SubPathwayInput

DNA/85 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: probable carnitine operon oxidoreductase CaiA
stoichiometric coefficient: 1.0

Protein/6662 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Crotonobetainyl-CoA dehydrogenase
stoichiometric coefficient: 1.0

Crotonobetainyl-CoA:carnitine CoA-transferase
type: Protein
entity reference: Crotonobetainyl-CoA:carnitine CoA-transferase

Reference/UniProt P0AEC3
type: UnificationXref
id: P0AEC3
db: UniProt

Reaction6176
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/3804 Cytoplasm/Stoichiometry/2.0
participant stoichiometry: Compound/PW C000041 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/4110 Cytoplasm/Stoichiometry/1.0
right: CRP-cAMP DNA-binding transcriptional dual regulator
spontaneous: false
left: cAMP-activated global transcriptional regulator CRP
left: cAMP
name: cAMP + 2 cAMP-activated global transcriptional regulator CRP → CRP-cAMP DNA-binding transcriptional dual regulator
conversion direction: LEFT_TO_RIGHT

Promoter
type: Dna
cellular location: Cytoplasm
entity reference: Promoter

Quinone
type: SmallMolecule
cellular location: Cell Membrane
entity reference: Quinone

SubPathwayInteraction475479
type: Interaction
name: SubPathwayReaction
name: SubPathway475479Reaction
participant: γ-butyrobetainyl-CoA:carnitine CoA transferase

Reference/ChEBI CHEBI 17489
type: UnificationXref
id: CHEBI:17489
db: ChEBI

probable carnitine operon oxidoreductase CaiA
type: Dna
cellular location: Cytosol
entity reference: probable carnitine operon oxidoreductase CaiA

Reference/BioCyc CAMP
type: UnificationXref
id: CAMP
db: BioCyc

SubPathwayInteraction475476
type: Interaction
name: SubPathway475476Reaction
name: SubPathwayReaction
participant: Crotonobetainyl-CoA dehydrogenase

Interaction5862
type: MolecularInteraction
interaction type: direct_interaction
name: RNA polymerase sigma 70 activates Promoter
participant: RNA polymerase sigma 70
participant: Promoter

Reference/UniProt P0A7Z4
type: UnificationXref
id: P0A7Z4
db: UniProt

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

γ-butyrobetainyl-CoA:carnitine CoA transferase
type: Complex
component stoichiometry: Protein/6507 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Crotonobetainyl-CoA:carnitine CoA-transferase

SubPathwayInteraction475480
type: Interaction
name: SubPathway475480Reaction
name: SubPathwayReaction
participant: Probable crotonobetaine/carnitine-CoA ligase

Protein/7579 Cell Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Aerobic respiration control sensor protein ArcB
stoichiometric coefficient: 2.0

Probable crotonobetaine/carnitine-CoA ligase
type: Protein
cellular location: Cytosol
entity reference: Probable crotonobetaine/carnitine-CoA ligase

Reference/UniProt P00579
type: UnificationXref
id: P00579
db: UniProt

Reference/TAXONOMY 562
type: UnificationXref
id: 562
db: TAXONOMY

Reference/BioCyc CARNITINE
type: UnificationXref
id: CARNITINE
db: BioCyc

Reference/UniProt P0AE58
type: UnificationXref
id: P0AE58
db: UniProt

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/GENE ONTOLOGY GO 0005737
type: UnificationXref
id: GO:0005737
db: GENE ONTOLOGY

Reference/CAS 60-92-4
type: UnificationXref
id: 60-92-4
db: CAS

Signal recognition particle protein
type: ProteinReference
xref: Reference/UniProt P0AGD7

RNA polymerase, sigma 70 (sigma D) factor
type: Protein
cellular location: Cytoplasm
entity reference: RNA polymerase, sigma 70 (sigma D) factor

Aerobic respiration control protein ArcA
type: Protein
cellular location: Cytosol
entity reference: Aerobic respiration control protein ArcA

cAMP
type: SmallMolecule
cellular location: Cytoplasm
entity reference: cAMP

L-carnitine/gamma-butyrobetaine antiporter
type: ProteinReference
xref: Reference/UniProt P31553
organism: Escherichia coli

Probable crotonobetaine/carnitine-CoA ligase
type: ProteinReference
xref: Reference/UniProt P31552
organism: Escherichia coli

DNA/47 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Promoter
stoichiometric coefficient: 1.0

Operon: Carnitine Operon
type: Pathway
pathway order: PathwaySubPathway/475480
pathway order: PathwayInteraction/5862
pathway order: PathwaySubPathway/475486
pathway order: PathwayEnzymeReaction/6449949
pathway order: PathwaySubPathway/475476
pathway order: PathwayEnzymeReaction/2128061
pathway order: PathwayEnzymeReaction/2129498
pathway order: PathwayEnzymeReaction/6449769
pathway order: PathwaySubPathway/475484
pathway order: PathwayEnzymeReaction/2128127
pathway order: PathwayEnzymeReaction/2129502
pathway order: PathwayEnzymeReaction/2128126
pathway order: PathwayEnzymeReaction/2129506
pathway order: PathwaySubPathway/475479
pathway order: PathwayEnzymeReaction/2128128
pathway order: PathwayInteraction/2963
pathway order: PathwayInteraction/8084
pathway order: PathwayTransport/6450864
pathway order: PathwayInteraction/2961
pathway order: PathwayInteraction/8086
pathway order: PathwayEnzymeReaction/2129507
pathway order: PathwayInteraction/8085
pathway order: PathwayTransport/6450740
pathway order: PathwayEnzymeReaction/6450268
pathway component: Reaction180667
pathway component: Reaction180766
pathway component: Reaction180669
pathway component: TransportCatalysis48960
pathway component: Reaction180668
pathway component: Reaction180767
pathway component: TransportCatalysis48961
pathway component: Reaction180663
pathway component: Interaction8086
pathway component: Interaction8084
pathway component: Interaction8085
pathway component: Interaction2961
pathway component: Reaction180769
pathway component: Interaction5862
pathway component: Transport68429
pathway component: Reaction1034480
pathway component: Transport68428
pathway component: Interaction2963
pathway component: L-Carnitine Degradation I
pathway component: Reaction6176
pathway component: Reaction180770
pathway component: Reaction1034640
xref: Reference/PathWhiz PW001875
xref: Reference/SMPDB SMP0001889
organism: Escherichia coli

ArcB
type: Complex
component stoichiometry: Protein/7579 Cytoplasm/Stoichiometry/2.0
cellular location: Cytoplasm
component: Aerobic respiration control sensor protein ArcB

L-Carnitine Degradation I
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway475480
pathway order: SubPathwayInteractionSteps/SubPathway475484
pathway order: SubPathwayInteractionSteps/SubPathway475486
pathway order: SubPathwayInteractionSteps/SubPathway475476
pathway order: SubPathwayInteractionSteps/SubPathway475479
pathway component: SubPathwayInteraction475479
pathway component: SubPathwayInteraction475484
pathway component: SubPathwayInteraction475486
pathway component: SubPathwayInteraction475476
pathway component: SubPathwayInteraction475480
xref: Reference/SMPDB SMP0002051
xref: Reference/PathWhiz PW002037
name: SubPathway

DNA/84 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: probable carnitine transporter
stoichiometric coefficient: 1.0

Protein/6061 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: DNA-directed RNA polymerase subunit alpha
stoichiometric coefficient: 2.0

TransportCatalysis48960
type: Catalysis
controller: Signal recognition particle protein
controlled: Transport68428
control type: ACTIVATION

TransportCatalysis48961
type: Catalysis
controller: L-carnitine/gamma-butyrobetaine antiporter
controlled: Transport68429
control type: ACTIVATION

SubPathwayInteraction475484
type: Interaction
name: SubPathway475484Reaction
name: SubPathwayReaction
participant: Carnitinyl-CoA dehydratase

SubPathwayInteraction475486
type: Interaction
name: SubPathwayReaction
name: SubPathway475486Reaction
participant: carnitine operon protein CaiE

Compound/PW C000044 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

Crotonobetainyl-CoA dehydrogenase
type: Protein
entity reference: Crotonobetainyl-CoA dehydrogenase
name: SubPathwayInput

Reference/UniProt P0A8V2
type: UnificationXref
id: P0A8V2
db: UniProt

Reference/PubChem-compound 10917
type: UnificationXref
id: 10917
db: PubChem-compound

DNA-directed RNA polymerase subunit alpha
type: ProteinReference
xref: Reference/UniProt P0A7Z4
organism: BiologicalState1078

Cytoplasm
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005737

Reference/ChemSpider 10455
type: UnificationXref
id: 10455
db: ChemSpider

caiF
type: Dna
cellular location: Cytoplasm
entity reference: caiF

probable crotonoβine/carnitine-CoA ligase
type: Dna
cellular location: Cytosol
entity reference: probable crotonoβine/carnitine-CoA ligase

Crotonobetainyl-CoA:carnitine CoA-transferase
type: ProteinReference
xref: Reference/UniProt P31572
organism: Escherichia coli

Carnitinyl-CoA dehydratase
type: ProteinReference
xref: Reference/UniProt P31551
organism: Escherichia coli

ProteinComplex/4110 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: CRP-cAMP DNA-binding transcriptional dual regulator
stoichiometric coefficient: 1.0

Carnitinyl-CoA dehydratase
type: Protein
cellular location: Cytosol
entity reference: Carnitinyl-CoA dehydratase

Escherichia coli
type: BioSource
xref: Reference/TAXONOMY 562

γ-butyrobetainyl-CoA:carnitine CoA transferase
type: Complex
component stoichiometry: Protein/6507/Stoichiometry/2.0
component: Crotonobetainyl-CoA:carnitine CoA-transferase
name: SubPathwayInput

DNA/87 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: probable crotonoβine/carnitine-CoA ligase
stoichiometric coefficient: 1.0

Quinone
type: SmallMoleculeReference
xref: Reference/ChemSpider 4489
xref: Reference/CAS 106-51-4
xref: Reference/KEGG Compound C00472
xref: Reference/ChEBI CHEBI 16509
xref: Reference/BioCyc CPD-8130
xref: Reference/PubChem-compound 4650
xref: Reference/HMDB HMDB0003364
chemical formula: C6H4O2
molecular weight: 108.021126
structure: ChemicalStructure/PW C001860

Reference/UniProt P0AGD7
type: UnificationXref
id: P0AGD7
db: UniProt

DNA/88 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: carnitine racemase
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16509
type: UnificationXref
id: CHEBI:16509
db: ChEBI

Protein/28684 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Transcriptional activatory protein CaiF
stoichiometric coefficient: 1.0

Protein/10248 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: cAMP-activated global transcriptional regulator CRP
stoichiometric coefficient: 2.0

Reference/ChemSpider 4489
type: UnificationXref
id: 4489
db: ChemSpider

Aerobic respiration control protein ArcA
type: Protein
cellular location: Cytoplasm
entity reference: Aerobic respiration control protein ArcA

Crotonobetainyl-CoA dehydrogenase
type: Protein
cellular location: Cytosol
entity reference: Crotonobetainyl-CoA dehydrogenase

Reference/BioCyc CPD-8130
type: UnificationXref
id: CPD-8130
db: BioCyc

Transport68429
type: Transport
participant stoichiometry: Compound/PW C000044 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000044 Extracellular Space/Stoichiometry/1.0
right: L-Carnitine
spontaneous: false
left: L-Carnitine
name: L-Carnitine (→) Transport: Escherichia coli (strain K12), Extracellular Space to Escherichia coli (strain K12), Cytoplasm
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000044
type: ChemicalStructure
structure format: SMILES
structure data: C[N+](C)(C)C[C@H](O)CC([O-])=O

ChemicalStructure/PW C000041
type: ChemicalStructure
structure format: SMILES

Transport68428
type: Transport
participant stoichiometry: Protein/7379 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/7379 Cell Membrane/Stoichiometry/1.0
right: L-carnitine/gamma-butyrobetaine antiporter
spontaneous: false
left: L-carnitine/gamma-butyrobetaine antiporter
name: L-carnitine/gamma-butyrobetaine antiporter (→) Transport: Escherichia coli (strain K12), Cytoplasm to Escherichia coli (strain K12), Cell Membrane
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P31572
type: UnificationXref
id: P31572
db: UniProt

carnitine operon protein CaiE
type: Protein
entity reference: carnitine operon protein CaiE
name: SubPathwayInput

Signal recognition particle protein
type: Protein
entity reference: Signal recognition particle protein

Reference/HMDB HMDB0000058
type: UnificationXref
id: HMDB0000058
db: HMDB

DNA-directed RNA polymerase subunit beta
type: ProteinReference
xref: Reference/UniProt P0A8V2
organism: BiologicalState1078

DNA-directed RNA polymerase subunit beta'
type: ProteinReference
xref: Reference/UniProt P0A8T7
organism: BiologicalState1078

ChemicalStructure/PW C001860
type: ChemicalStructure
structure format: SMILES
structure data: O=C1C=CC(=O)C=C1

Transcriptional activatory protein CaiF
type: ProteinReference
xref: Reference/UniProt P0AE58
organism: BiologicalState1078

BiologicalState1078
type: BioSource
xref: Reference/TAXONOMY 83333
name: Escherichia coli (strain K12)

probable carnitine transporter
type: Dna
cellular location: Cytosol
entity reference: probable carnitine transporter

Reaction180770
type: BiochemicalReaction
participant stoichiometry: DNA/143 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/89 Cytosol/Stoichiometry/1.0
right: terminator
spontaneous: false
left: carnitine operon protein CaiE
name: carnitine operon protein CaiE → terminator
conversion direction: LEFT_TO_RIGHT

cAMP-activated global transcriptional regulator CRP
type: ProteinReference
xref: Reference/UniProt P0ACJ8
organism: BiologicalState1078

Reaction1034640
type: BiochemicalReaction
participant stoichiometry: DNA/559 Cytoplasm/Stoichiometry/1.0
participant stoichiometry: Protein/28684 Cytoplasm/Stoichiometry/1.0
right: Transcriptional activatory protein CaiF
spontaneous: false
left: caiF
name: caiF → Transcriptional activatory protein CaiF
conversion direction: LEFT_TO_RIGHT

Reaction180766
type: BiochemicalReaction
participant stoichiometry: Protein/6506 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/88 Cytosol/Stoichiometry/1.0
right: Carnitinyl-CoA dehydratase
spontaneous: false
left: carnitine racemase
name: carnitine racemase → crotonobetainyl-CoA hydratase
conversion direction: LEFT_TO_RIGHT

Cell Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005886

Protein/6506 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Carnitinyl-CoA dehydratase
stoichiometric coefficient: 1.0

Protein/7379 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-carnitine/gamma-butyrobetaine antiporter
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16347
type: UnificationXref
id: CHEBI:16347
db: ChEBI

Reaction180767
type: BiochemicalReaction
participant stoichiometry: Protein/10337 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/89 Cytosol/Stoichiometry/1.0
right: carnitine operon protein CaiE
spontaneous: false
left: carnitine operon protein CaiE
name: carnitine operon protein CaiE → Putative transferase
conversion direction: LEFT_TO_RIGHT

Protein/7379 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-carnitine/gamma-butyrobetaine antiporter
stoichiometric coefficient: 1.0

RNA polymerase, sigma 70 (sigma D) factor
type: ProteinReference
xref: Reference/UniProt P00579
organism: BiologicalState1078

Reference/UniProt P60584
type: UnificationXref
id: P60584
db: UniProt

Interaction2961
type: MolecularInteraction
interaction type: direct_interaction
name: ArcA-Phosphorylated DNA-binding transcriptional dual regulator activates Promoter
participant: Promoter
participant: Aerobic respiration control protein ArcA

cAMP-activated global transcriptional regulator CRP
type: Protein
cellular location: Cytoplasm
entity reference: cAMP-activated global transcriptional regulator CRP

Reaction180769
type: BiochemicalReaction
participant stoichiometry: DNA/84 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/47 Cytosol/Stoichiometry/1.0
right: probable carnitine transporter
spontaneous: false
left: Promoter
name: Promoter → probable carnitine transporter
conversion direction: LEFT_TO_RIGHT

Interaction2963
type: MolecularInteraction
interaction type: direct_interaction
name: CRP-cAMP DNA-binding transcriptional dual regulator activates Promoter
participant: Promoter
participant: CRP-cAMP DNA-binding transcriptional dual regulator

Reference/HMDB HMDB0000062
type: UnificationXref
id: HMDB0000062
db: HMDB

probable carnitine transporter
type: DnaReference
organism: Escherichia coli

L-carnitine dehydratase
type: DnaReference
organism: Escherichia coli

probable carnitine operon oxidoreductase CaiA
type: DnaReference
organism: Escherichia coli

carnitine racemase
type: DnaReference
organism: Escherichia coli

L-Carnitine
type: SmallMolecule
cellular location: Cytoplasm
entity reference: L-Carnitine

probable crotonoβine/carnitine-CoA ligase
type: DnaReference
organism: Escherichia coli

carnitine operon protein CaiE
type: DnaReference
organism: Escherichia coli

Aerobic respiration control sensor protein ArcB
type: Protein
cellular location: Cytoplasm
entity reference: Aerobic respiration control sensor protein ArcB

Crotonobetainyl-CoA dehydrogenase
type: ProteinReference
xref: Reference/UniProt P60584
organism: Escherichia coli

Protein/7579 Cytoplasm/Stoichiometry/2.0
type: Stoichiometry
physical entity: Aerobic respiration control sensor protein ArcB
stoichiometric coefficient: 2.0

L-carnitine/gamma-butyrobetaine antiporter
type: Protein
cellular location: Cytoplasm
entity reference: L-carnitine/gamma-butyrobetaine antiporter

Protein/7379 Cell Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-carnitine/gamma-butyrobetaine antiporter
stoichiometric coefficient: 1.0

DNA-directed RNA polymerase subunit beta'
type: Protein
cellular location: Cytoplasm
entity reference: DNA-directed RNA polymerase subunit beta'

L-carnitine/gamma-butyrobetaine antiporter
type: Protein
cellular location: Cytosol
entity reference: L-carnitine/gamma-butyrobetaine antiporter

Reaction180667
type: BiochemicalReaction
participant stoichiometry: DNA/85 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/6662 Cytosol/Stoichiometry/1.0
right: Crotonobetainyl-CoA dehydrogenase
spontaneous: false
left: probable carnitine operon oxidoreductase CaiA
name: probable carnitine operon oxidoreductase CaiA → crotonobetainyl-CoA reductase
conversion direction: LEFT_TO_RIGHT

Reaction180669
type: BiochemicalReaction
participant stoichiometry: Protein/7257 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/87 Cytosol/Stoichiometry/1.0
right: Probable crotonobetaine/carnitine-CoA ligase
spontaneous: false
left: probable crotonoβine/carnitine-CoA ligase
name: probable crotonoβine/carnitine-CoA ligase → carnitine-CoA ligase
conversion direction: LEFT_TO_RIGHT

Reference/PubChem-compound 6076
type: UnificationXref
id: 6076
db: PubChem-compound

Reaction180668
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/4010 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/86 Cytosol/Stoichiometry/1.0
right: γ-butyrobetainyl-CoA:carnitine CoA transferase
spontaneous: false
left: L-carnitine dehydratase
name: L-carnitine dehydratase → γ-butyrobetainyl-CoA:carnitine CoA transferase
conversion direction: LEFT_TO_RIGHT

ArcB
type: Complex
component stoichiometry: Protein/7579 Cell Membrane/Stoichiometry/2.0
cellular location: Cell Membrane
component: Aerobic respiration control sensor protein ArcB

Reaction180663
type: BiochemicalReaction
participant stoichiometry: Protein/7379 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/84 Cytosol/Stoichiometry/1.0
right: L-carnitine/gamma-butyrobetaine antiporter
spontaneous: false
left: probable carnitine transporter
name: probable carnitine transporter → L-carnitine/gamma-butyrobetaine antiporter
conversion direction: LEFT_TO_RIGHT

Protein/10337 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: carnitine operon protein CaiE
stoichiometric coefficient: 1.0

Promoter
type: Dna
cellular location: Cytosol
entity reference: Promoter

Reference/CAS 106-51-4
type: UnificationXref
id: 106-51-4
db: CAS

DNA/47 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: Promoter
stoichiometric coefficient: 1.0

Reference/UniProt P0ACJ8
type: UnificationXref
id: P0ACJ8
db: UniProt

Compound/PW C000044 Cytoplasm/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Carnitine
stoichiometric coefficient: 1.0

Protein/6507 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Crotonobetainyl-CoA:carnitine CoA-transferase
stoichiometric coefficient: 2.0

Protein/7257 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Probable crotonobetaine/carnitine-CoA ligase
stoichiometric coefficient: 1.0

Reference/UniProt P0A8T7
type: UnificationXref
id: P0A8T7
db: UniProt

caiF
type: DnaReference
organism: BiologicalState1078