Protein/6405 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
stoichiometric coefficient: 1.0

Peptidoglycan D,D-transpeptidase FtsI
type: Dna
cellular location: Cytosol
entity reference: Peptidoglycan D,D-transpeptidase FtsI

direct_interaction
type: InteractionVocabulary

UDP-3-O-acyl-N-acetylglucosamine deacetylase
type: Dna
cellular location: Cytosol
entity reference: UDP-3-O-acyl-N-acetylglucosamine deacetylase

ProteinComplex/13640 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cell division protein FtsZ
stoichiometric coefficient: 1.0

UDP-N-acetylmuramate--L-alanine ligase
type: Protein
cellular location: Cytosol
entity reference: UDP-N-acetylmuramate--L-alanine ligase

Reference/UniProt P0A6J8
type: UnificationXref
id: P0A6J8
db: UniProt

Cell division protein FtsQ
type: Dna
cellular location: Cytosol
entity reference: Cell division protein FtsQ

Protein/23134 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cell division protein FtsQ
stoichiometric coefficient: 1.0

Peptidoglycan synthase ftsI
type: ProteinReference
xref: Reference/UniProt P0AD68
organism: Escherichia coli

UDP-N-acetylmuramoylalanine--D-glutamate ligase
type: ProteinReference
xref: Reference/UniProt P14900
organism: Escherichia coli

DNA/308 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Peptidoglycan D,D-transpeptidase FtsI
stoichiometric coefficient: 1.0

DNA/315 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cell division protein FtsA
stoichiometric coefficient: 1.0

LexA repressor
type: Protein
cellular location: Cytosol
entity reference: LexA repressor

L-alanine-adding enzyme
type: DnaReference
organism: Escherichia coli

(ddl) D-alanine-D-alanine ligase B
type: DnaReference
organism: Escherichia coli

ChemicalStructure/PW C041212
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P0AD68
type: UnificationXref
id: P0AD68
db: UniProt

Transcriptional regulator MraZ
type: Dna
cellular location: Cytosol
entity reference: Transcriptional regulator MraZ

D-alanine--D-alanine ligase B
type: ProteinReference
xref: Reference/UniProt P07862
organism: Escherichia coli

Protein/6026 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
stoichiometric coefficient: 1.0

DNA/312 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetylmuramoylalanine--D-glutamate ligase
stoichiometric coefficient: 1.0

Reference/UniProt P0A9A6
type: UnificationXref
id: P0A9A6
db: UniProt

Promoter
type: DnaReference
organism: Escherichia coli

Protein/6368 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: UDP-N-acetylmuramate--L-alanine ligase
stoichiometric coefficient: 2.0

Ribosomal RNA small subunit methyltransferase H
type: ProteinReference
xref: Reference/UniProt P60390
organism: Escherichia coli

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

Cell division protein FtsA
type: Protein
cellular location: Cytosol
entity reference: Cell division protein FtsA

transferase in peptidoglycan synthesis
type: DnaReference
organism: Escherichia coli

lexA DNA-binding transcriptional repressor
type: Complex
component stoichiometry: Protein/10414 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: LexA repressor

Protein/7673 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribosomal RNA small subunit methyltransferase H
stoichiometric coefficient: 1.0

ProteinComplex/3675 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetylmuramate-alanine ligase
stoichiometric coefficient: 1.0

Protein/6018 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phospho-N-acetylmuramoyl-pentapeptide-transferase
stoichiometric coefficient: 1.0

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
type: ProteinReference
xref: Reference/UniProt P17443
organism: Escherichia coli

Protein RecA
type: Protein
cellular location: Cytosol
entity reference: Protein RecA

DNA/311 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phospho-N-acetylmuramoyl-pentapeptide-transferase
stoichiometric coefficient: 1.0

Ribosomal RNA small subunit methyltransferase H
type: Dna
cellular location: Cytosol
entity reference: Ribosomal RNA small subunit methyltransferase H

Guanosine 3'-diphosphate 5'-triphosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0060480
xref: Reference/PubChem-compound 38166
chemical formula: C10H18N5O20P5
molecular weight: 682.92334
structure: ChemicalStructure/PW C041212

Reference/UniProt P0A7G6
type: UnificationXref
id: P0A7G6
db: UniProt

Reference/UniProt P07862
type: UnificationXref
id: P07862
db: UniProt

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

ρ-independent terminator
type: DnaReference
organism: Escherichia coli

UDP-N-acetylmuramate--L-alanine ligase
type: ProteinReference
xref: Reference/UniProt P17952
organism: Escherichia coli

Cell division protein FtsZ
type: Protein
cellular location: Cytosol
entity reference: Cell division protein FtsZ

Cell division protein FtsA
type: Dna
cellular location: Cytosol
entity reference: Cell division protein FtsA

Protein/6337 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetylmuramoylalanine--D-glutamate ligase
stoichiometric coefficient: 1.0

(ddl) D-alanine-D-alanine ligase B
type: Dna
cellular location: Cytosol
entity reference: (ddl) D-alanine-D-alanine ligase B

Phospho-N-acetylmuramoyl-pentapeptide-transferase
type: ProteinReference
xref: Reference/UniProt P0A6W3
organism: Escherichia coli

Ribosomal RNA small subunit methyltransferase H
type: Protein
cellular location: Cytosol
entity reference: Ribosomal RNA small subunit methyltransferase H

UDP-N-acetylmuramoylalanine--D-glutamate ligase
type: Dna
cellular location: Cytosol
entity reference: UDP-N-acetylmuramoylalanine--D-glutamate ligase

Reference/UniProt P0A6W3
type: UnificationXref
id: P0A6W3
db: UniProt

LexA repressor
type: ProteinReference
xref: Reference/UniProt P0A7C2
organism: Escherichia coli

D-alanine--D-alanine ligase B
type: Protein
cellular location: Cytosol
entity reference: D-alanine--D-alanine ligase B

Cell division protein FtsL
type: Protein
cellular location: Cytosol
entity reference: Cell division protein FtsL

UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
type: ProteinReference
xref: Reference/UniProt P0A725
organism: Escherichia coli

ρ-independent terminator
type: Dna
cellular location: Cytosol
entity reference: ρ-independent terminator

D-alanine ligase
type: Complex
cellular location: Cytosol
component: D-alanine--D-alanine ligase A
component: D-alanine--D-alanine ligase B

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
type: Dna
cellular location: Cytosol
entity reference: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
type: Protein
cellular location: Cytosol
entity reference: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Reference/UniProt P17443
type: UnificationXref
id: P17443
db: UniProt

Reference/UniProt P60390
type: UnificationXref
id: P60390
db: UniProt

Protein/6318 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
stoichiometric coefficient: 1.0

Reference/TAXONOMY 562
type: UnificationXref
id: 562
db: TAXONOMY

Protein/10414 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: LexA repressor
stoichiometric coefficient: 2.0

ProteinComplex/1228 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-alanine ligase
stoichiometric coefficient: 1.0

Transcriptional regulator MraZ
type: Complex
component stoichiometry: Protein/23132 Cytosol/Stoichiometry/12.0
cellular location: Cytosol
component: Transcriptional regulator MraZ

Interaction5857
type: MolecularInteraction
interaction type: direct_interaction
name: Protein RecA inhibits lexA DNA-binding transcriptional repressor
participant: Protein RecA
participant: lexA DNA-binding transcriptional repressor

Protein/6217 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Peptidoglycan synthase ftsI
stoichiometric coefficient: 1.0

UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
type: Protein
cellular location: Cytosol
entity reference: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Transcriptional regulatory protein RcsB
type: ProteinReference
xref: Reference/UniProt P0DMC7
organism: Escherichia coli

transferase in peptidoglycan synthesis
type: Dna
cellular location: Cytosol
entity reference: transferase in peptidoglycan synthesis

UDP-N-acetylmuramate-alanine ligase
type: Complex
component stoichiometry: Protein/6368 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: UDP-N-acetylmuramate--L-alanine ligase

DNA/292 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: ρ-independent terminator
stoichiometric coefficient: 1.0

Reference/UniProt P0A7C2
type: UnificationXref
id: P0A7C2
db: UniProt

Reference/UniProt P07026
type: UnificationXref
id: P07026
db: UniProt

D-alanine--D-alanine ligase A
type: ProteinReference
xref: Reference/UniProt P0A6J8
organism: Escherichia coli

DNA/306 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Ribosomal RNA small subunit methyltransferase H
stoichiometric coefficient: 1.0

DNA/317 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-3-O-acyl-N-acetylglucosamine deacetylase
stoichiometric coefficient: 1.0

DNA/47 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Promoter
stoichiometric coefficient: 1.0

Cell division protein FtsQ
type: Protein
cellular location: Cytosol
entity reference: Cell division protein FtsQ

Reaction187122
type: BiochemicalReaction
participant stoichiometry: Protein/6363 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/109 Cytosol/Stoichiometry/1.0
right: UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
spontaneous: false
left: transferase in peptidoglycan synthesis
name: transferase in peptidoglycan synthesis → N-acetylglucosaminyl transferase
conversion direction: LEFT_TO_RIGHT

Reaction187123
type: BiochemicalReaction
participant stoichiometry: DNA/112 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/3675 Cytosol/Stoichiometry/1.0
right: UDP-N-acetylmuramate-alanine ligase
spontaneous: false
left: L-alanine-adding enzyme
name: L-alanine-adding enzyme → UDP-N-acetylmuramate-alanine ligase
conversion direction: LEFT_TO_RIGHT

Reaction187124
type: BiochemicalReaction
participant stoichiometry: DNA/113 Cytosol/Stoichiometry/1.0
participant stoichiometry: ProteinComplex/1228 Cytosol/Stoichiometry/1.0
right: D-alanine ligase
spontaneous: false
left: (ddl) D-alanine-D-alanine ligase B
name: (ddl) D-alanine-D-alanine ligase B → D-alanine ligase
conversion direction: LEFT_TO_RIGHT

Reaction187125
type: BiochemicalReaction
participant stoichiometry: Protein/23134 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/314 Cytosol/Stoichiometry/1.0
right: Cell division protein FtsQ
spontaneous: false
left: Cell division protein FtsQ
name: Cell division protein FtsQ → Cell division protein FtsQ
conversion direction: LEFT_TO_RIGHT

Reaction187126
type: BiochemicalReaction
participant stoichiometry: DNA/314 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/47 Cytosol/Stoichiometry/1.0
right: Cell division protein FtsQ
spontaneous: false
left: Promoter
name: Promoter → Cell division protein FtsQ
conversion direction: LEFT_TO_RIGHT

Reaction187127
type: BiochemicalReaction
participant stoichiometry: Protein/23135 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/315 Cytosol/Stoichiometry/1.0
right: Cell division protein FtsA
spontaneous: false
left: Cell division protein FtsA
name: Cell division protein FtsA → Cell division protein FtsA
conversion direction: LEFT_TO_RIGHT

Protein/10121 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Probable peptidoglycan glycosyltransferase FtsW
stoichiometric coefficient: 1.0

Reaction187128
type: BiochemicalReaction
participant stoichiometry: DNA/315 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/47 Cytosol/Stoichiometry/1.0
right: Cell division protein FtsA
spontaneous: false
left: Promoter
name: Promoter → Cell division protein FtsA
conversion direction: LEFT_TO_RIGHT

Reaction187129
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/13640 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/316 Cytosol/Stoichiometry/1.0
right: Cell division protein FtsZ
spontaneous: false
left: Cell division protein FtsZ
name: Cell division protein FtsZ → Cell division protein FtsZ
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P0A725
type: UnificationXref
id: P0A725
db: UniProt

Reference/UniProt P11880
type: UnificationXref
id: P11880
db: UniProt

Probable peptidoglycan glycosyltransferase FtsW
type: Protein
cellular location: Cytosol
entity reference: Probable peptidoglycan glycosyltransferase FtsW

Reaction187120
type: BiochemicalReaction
participant stoichiometry: Protein/6337 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/312 Cytosol/Stoichiometry/1.0
right: UDP-N-acetylmuramoylalanine--D-glutamate ligase
spontaneous: false
left: UDP-N-acetylmuramoylalanine--D-glutamate ligase
name: UDP-N-acetylmuramoylalanine--D-glutamate ligase → MurD synthetase
conversion direction: LEFT_TO_RIGHT

Reaction187121
type: BiochemicalReaction
participant stoichiometry: DNA/313 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/10121 Cytosol/Stoichiometry/1.0
right: Probable peptidoglycan glycosyltransferase FtsW
spontaneous: false
left: Probable peptidoglycan glycosyltransferase FtsW
name: Probable peptidoglycan glycosyltransferase FtsW → Probable peptidoglycan glycosyltransferase FtsW
conversion direction: LEFT_TO_RIGHT

Transcriptional regulator MraZ
type: DnaReference
organism: Escherichia coli

Reaction187119
type: BiochemicalReaction
participant stoichiometry: Protein/6018 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/311 Cytosol/Stoichiometry/1.0
right: Phospho-N-acetylmuramoyl-pentapeptide-transferase
spontaneous: false
left: Phospho-N-acetylmuramoyl-pentapeptide-transferase
name: Phospho-N-acetylmuramoyl-pentapeptide-transferase → phospho-N-acetylmuramoyl-pentapeptide transferase
conversion direction: LEFT_TO_RIGHT

Reaction187111
type: BiochemicalReaction
participant stoichiometry: DNA/306 Cytosol/Stoichiometry/1.0
participant stoichiometry: Protein/7673 Cytosol/Stoichiometry/1.0
right: Ribosomal RNA small subunit methyltransferase H
spontaneous: false
left: Ribosomal RNA small subunit methyltransferase H
name: Ribosomal RNA small subunit methyltransferase H → Ribosomal RNA small subunit methyltransferase H
conversion direction: LEFT_TO_RIGHT

Reaction187112
type: BiochemicalReaction
participant stoichiometry: DNA/305 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/47 Cytosol/Stoichiometry/1.0
right: Transcriptional regulator MraZ
spontaneous: false
left: Promoter
name: Promoter → Transcriptional regulator MraZ
conversion direction: LEFT_TO_RIGHT

Reaction187113
type: BiochemicalReaction
participant stoichiometry: DNA/306 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/47 Cytosol/Stoichiometry/1.0
right: Ribosomal RNA small subunit methyltransferase H
spontaneous: false
left: Promoter
name: Promoter → Ribosomal RNA small subunit methyltransferase H
conversion direction: LEFT_TO_RIGHT

Operon: dcw cluster Genes
type: Pathway
pathway order: PathwayEnzymeReaction/2168669
pathway order: PathwayEnzymeReaction/2168668
pathway order: PathwayEnzymeReaction/2168667
pathway order: PathwayEnzymeReaction/2168662
pathway order: PathwayEnzymeReaction/2168661
pathway order: PathwayEnzymeReaction/2168683
pathway order: PathwayEnzymeReaction/2168660
pathway order: PathwayEnzymeReaction/2168682
pathway order: PathwayInteraction/5857
pathway order: PathwayEnzymeReaction/2168681
pathway order: PathwayEnzymeReaction/2168666
pathway order: PathwayEnzymeReaction/2168665
pathway order: PathwayEnzymeReaction/2168664
pathway order: PathwayEnzymeReaction/2168663
pathway order: PathwayInteraction/2979
pathway order: PathwayEnzymeReaction/2168680
pathway order: PathwayEnzymeReaction/2168659
pathway order: PathwayEnzymeReaction/2168679
pathway order: PathwayEnzymeReaction/2168678
pathway order: PathwayEnzymeReaction/2168673
pathway order: PathwayEnzymeReaction/2168672
pathway order: PathwayEnzymeReaction/2168671
pathway order: PathwayEnzymeReaction/2168670
pathway order: PathwayEnzymeReaction/2168677
pathway order: PathwayEnzymeReaction/2168676
pathway order: PathwayEnzymeReaction/2168674
pathway order: PathwayInteraction/2982
pathway order: PathwayInteraction/2983
pathway order: PathwayInteraction/2980
pathway order: PathwayInteraction/2981
pathway component: Reaction187122
pathway component: Reaction187123
pathway component: Interaction2979
pathway component: Reaction187124
pathway component: Reaction187125
pathway component: Reaction187126
pathway component: Reaction187127
pathway component: Reaction187128
pathway component: Reaction187129
pathway component: Reaction187120
pathway component: Reaction187121
pathway component: Reaction187119
pathway component: Interaction2981
pathway component: Interaction2982
pathway component: Interaction2983
pathway component: Interaction2980
pathway component: Reaction187111
pathway component: Reaction187133
pathway component: Reaction187112
pathway component: Reaction187113
pathway component: Reaction187114
pathway component: Reaction187115
pathway component: Interaction5857
pathway component: Reaction187116
pathway component: Reaction187117
pathway component: Reaction187118
pathway component: Reaction187130
pathway component: Reaction187131
pathway component: Reaction187110
pathway component: Reaction187132
xref: Reference/SMPDB SMP0001897
xref: Reference/PathWhiz PW001883
organism: Escherichia coli

Reaction187114
type: BiochemicalReaction
participant stoichiometry: Protein/23133 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/307 Cytosol/Stoichiometry/1.0
right: Cell division protein FtsL
spontaneous: false
left: Cell division protein FtsL
name: Cell division protein FtsL → Cell division protein FtsL
conversion direction: LEFT_TO_RIGHT

Reaction187115
type: BiochemicalReaction
participant stoichiometry: DNA/47 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/307 Cytosol/Stoichiometry/1.0
right: Cell division protein FtsL
spontaneous: false
left: Promoter
name: Promoter → Cell division protein FtsL
conversion direction: LEFT_TO_RIGHT

Reaction187116
type: BiochemicalReaction
participant stoichiometry: Protein/6217 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/308 Cytosol/Stoichiometry/1.0
right: Peptidoglycan synthase ftsI
spontaneous: false
left: Peptidoglycan D,D-transpeptidase FtsI
name: Peptidoglycan D,D-transpeptidase FtsI → essential cell division protein FtsI; penicillin-binding protein 3
conversion direction: LEFT_TO_RIGHT

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
type: Dna
cellular location: Cytosol
entity reference: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Reaction187117
type: BiochemicalReaction
participant stoichiometry: Protein/6405 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/309 Cytosol/Stoichiometry/1.0
right: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
spontaneous: false
left: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase → UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase
conversion direction: LEFT_TO_RIGHT

Reaction187118
type: BiochemicalReaction
participant stoichiometry: Protein/6318 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/310 Cytosol/Stoichiometry/1.0
right: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
spontaneous: false
left: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
name: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase → D-alanyl-D-alanine-adding enzyme
conversion direction: LEFT_TO_RIGHT

DNA/109 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: transferase in peptidoglycan synthesis
stoichiometric coefficient: 1.0

Reaction187110
type: BiochemicalReaction
participant stoichiometry: ProteinComplex/13635 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/305 Cytosol/Stoichiometry/1.0
right: Transcriptional regulator MraZ
spontaneous: false
left: Transcriptional regulator MraZ
name: Transcriptional regulator MraZ → Transcriptional regulator MraZ
conversion direction: LEFT_TO_RIGHT

Protein/6363 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
stoichiometric coefficient: 1.0

Cell division protein FtsL
type: Dna
cellular location: Cytosol
entity reference: Cell division protein FtsL

Escherichia coli
type: BioSource
xref: Reference/TAXONOMY 562

Cell division protein FtsQ
type: ProteinReference
xref: Reference/UniProt P06136
organism: Escherichia coli

Cell division protein FtsA
type: ProteinReference
xref: Reference/UniProt P0ABH0
organism: Escherichia coli

Cell division protein FtsZ
type: ProteinReference
xref: Reference/UniProt P0A9A6
organism: Escherichia coli

Regulatory protein SdiA
type: ProteinReference
xref: Reference/UniProt P07026
organism: Escherichia coli

Transcriptional regulatory protein RcsB
type: Protein
cellular location: Cytosol
entity reference: Transcriptional regulatory protein RcsB

DNA/313 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Probable peptidoglycan glycosyltransferase FtsW
stoichiometric coefficient: 1.0

Transcriptional regulator MraZ
type: ProteinReference
xref: Reference/UniProt P22186
organism: Escherichia coli

Cell division protein FtsZ
type: Dna
cellular location: Cytosol
entity reference: Cell division protein FtsZ

Cell division protein FtsL
type: ProteinReference
xref: Reference/UniProt P0AEN4
organism: Escherichia coli

UDP-N-acetylmuramoylalanine--D-glutamate ligase
type: Protein
cellular location: Cytosol
entity reference: UDP-N-acetylmuramoylalanine--D-glutamate ligase

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
type: Protein
cellular location: Cytosol
entity reference: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

Probable peptidoglycan glycosyltransferase FtsW
type: Dna
cellular location: Cytosol
entity reference: Probable peptidoglycan glycosyltransferase FtsW

Reference/PathWhiz PW001883
type: UnificationXref
id: PW001883
db: PathWhiz

Reference/PubChem-compound 38166
type: UnificationXref
id: 38166
db: PubChem-compound

DNA/310 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
stoichiometric coefficient: 1.0

Reaction187133
type: BiochemicalReaction
participant stoichiometry: DNA/292 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/317 Cytosol/Stoichiometry/1.0
right: ρ-independent terminator
spontaneous: false
left: UDP-3-O-acyl-N-acetylglucosamine deacetylase
name: UDP-3-O-acyl-N-acetylglucosamine deacetylase → ρ-independent terminator
conversion direction: LEFT_TO_RIGHT

Reaction187130
type: BiochemicalReaction
participant stoichiometry: DNA/316 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/47 Cytosol/Stoichiometry/1.0
right: Cell division protein FtsZ
spontaneous: false
left: Promoter
name: Promoter → Cell division protein FtsZ
conversion direction: LEFT_TO_RIGHT

Reaction187131
type: BiochemicalReaction
participant stoichiometry: Protein/6026 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/317 Cytosol/Stoichiometry/1.0
right: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
spontaneous: false
left: UDP-3-O-acyl-N-acetylglucosamine deacetylase
name: UDP-3-O-acyl-N-acetylglucosamine deacetylase → UDP-3-O-acyl-N-acetylglucosamine deacetylase
conversion direction: LEFT_TO_RIGHT

Reaction187132
type: BiochemicalReaction
participant stoichiometry: DNA/317 Cytosol/Stoichiometry/1.0
participant stoichiometry: DNA/47 Cytosol/Stoichiometry/1.0
right: UDP-3-O-acyl-N-acetylglucosamine deacetylase
spontaneous: false
left: Promoter
name: Promoter → UDP-3-O-acyl-N-acetylglucosamine deacetylase
conversion direction: LEFT_TO_RIGHT

Probable peptidoglycan glycosyltransferase FtsW
type: ProteinReference
xref: Reference/UniProt P0ABG4
organism: Escherichia coli

Transcriptional regulator MraZ
type: Protein
cellular location: Cytosol
entity reference: Transcriptional regulator MraZ

Reference/SMPDB SMP0001897
type: UnificationXref
id: SMP0001897
db: SMPDB

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
type: ProteinReference
xref: Reference/UniProt P22188
organism: Escherichia coli

Reference/UniProt P06136
type: UnificationXref
id: P06136
db: UniProt

Reference/UniProt P22186
type: UnificationXref
id: P22186
db: UniProt

Reference/UniProt P22188
type: UnificationXref
id: P22188
db: UniProt

Protein/23135 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cell division protein FtsA
stoichiometric coefficient: 1.0

Interaction2979
type: MolecularInteraction
interaction type: direct_interaction
name: Transcriptional regulator MraZ inhibits Promoter
participant: Promoter
participant: Transcriptional regulator MraZ

Protein RecA
type: ProteinReference
xref: Reference/UniProt P0A7G6
organism: Escherichia coli

DNA/305 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Transcriptional regulator MraZ
stoichiometric coefficient: 1.0

DNA/316 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cell division protein FtsZ
stoichiometric coefficient: 1.0

Guanosine 3'-diphosphate 5'-triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Guanosine 3'-diphosphate 5'-triphosphate

Reference/HMDB HMDB0060480
type: UnificationXref
id: HMDB0060480
db: HMDB

DNA/314 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cell division protein FtsQ
stoichiometric coefficient: 1.0

Protein/23133 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cell division protein FtsL
stoichiometric coefficient: 1.0

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
type: Protein
cellular location: Cytosol
entity reference: UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Reference/UniProt P17952
type: UnificationXref
id: P17952
db: UniProt

ProteinComplex/13635 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Transcriptional regulator MraZ
stoichiometric coefficient: 1.0

Protein/23132 Cytosol/Stoichiometry/12.0
type: Stoichiometry
physical entity: Transcriptional regulator MraZ
stoichiometric coefficient: 12.0

DNA/307 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cell division protein FtsL
stoichiometric coefficient: 1.0

Protein/23136 Cytosol/Stoichiometry/2.0
type: Stoichiometry
physical entity: Cell division protein FtsZ
stoichiometric coefficient: 2.0

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
type: DnaReference
organism: Escherichia coli

Phospho-N-acetylmuramoyl-pentapeptide-transferase
type: DnaReference
organism: Escherichia coli

UDP-N-acetylmuramoylalanine--D-glutamate ligase
type: DnaReference
organism: Escherichia coli

Probable peptidoglycan glycosyltransferase FtsW
type: DnaReference
organism: Escherichia coli

D-alanine--D-alanine ligase A
type: Protein
cellular location: Cytosol
entity reference: D-alanine--D-alanine ligase A

Cell division protein FtsQ
type: DnaReference
organism: Escherichia coli

Cell division protein FtsA
type: DnaReference
organism: Escherichia coli

Cell division protein FtsZ
type: DnaReference
organism: Escherichia coli

Peptidoglycan synthase ftsI
type: Protein
cellular location: Cytosol
entity reference: Peptidoglycan synthase ftsI

Reference/UniProt P0ABG4
type: UnificationXref
id: P0ABG4
db: UniProt

Ribosomal RNA small subunit methyltransferase H
type: DnaReference
organism: Escherichia coli

Cell division protein FtsL
type: DnaReference
organism: Escherichia coli

Reference/UniProt P0DMC7
type: UnificationXref
id: P0DMC7
db: UniProt

Peptidoglycan D,D-transpeptidase FtsI
type: DnaReference
organism: Escherichia coli

DNA/309 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
stoichiometric coefficient: 1.0

Phospho-N-acetylmuramoyl-pentapeptide-transferase
type: Protein
cellular location: Cytosol
entity reference: Phospho-N-acetylmuramoyl-pentapeptide-transferase

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
type: DnaReference
organism: Escherichia coli

Regulatory protein SdiA
type: Protein
cellular location: Cytosol
entity reference: Regulatory protein SdiA

Cell division protein FtsZ
type: Complex
component stoichiometry: Protein/23136 Cytosol/Stoichiometry/2.0
cellular location: Cytosol
component: Cell division protein FtsZ

DNA/112 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-alanine-adding enzyme
stoichiometric coefficient: 1.0

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
type: ProteinReference
xref: Reference/UniProt P11880
organism: Escherichia coli

Reference/UniProt P0ABH0
type: UnificationXref
id: P0ABH0
db: UniProt

Reference/UniProt P0AEN4
type: UnificationXref
id: P0AEN4
db: UniProt

Interaction2981
type: MolecularInteraction
interaction type: direct_interaction
name: Regulatory protein SdiA inhibits Promoter
participant: Promoter
participant: Regulatory protein SdiA

Promoter
type: Dna
cellular location: Cytosol
entity reference: Promoter

Interaction2982
type: MolecularInteraction
interaction type: direct_interaction
name: Guanosine 3'-diphosphate 5'-triphosphate activates Promoter
participant: Guanosine 3'-diphosphate 5'-triphosphate
participant: Promoter

Interaction2983
type: MolecularInteraction
interaction type: direct_interaction
name: RcsB activates Promoter
participant: Transcriptional regulatory protein RcsB
participant: Promoter

Phospho-N-acetylmuramoyl-pentapeptide-transferase
type: Dna
cellular location: Cytosol
entity reference: Phospho-N-acetylmuramoyl-pentapeptide-transferase

Reference/UniProt P14900
type: UnificationXref
id: P14900
db: UniProt

Interaction2980
type: MolecularInteraction
interaction type: direct_interaction
name: lexA DNA-binding transcriptional repressor inhibits Promoter
participant: Promoter
participant: lexA DNA-binding transcriptional repressor

DNA/113 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: (ddl) D-alanine-D-alanine ligase B
stoichiometric coefficient: 1.0

L-alanine-adding enzyme
type: Dna
cellular location: Cytosol
entity reference: L-alanine-adding enzyme

UDP-3-O-acyl-N-acetylglucosamine deacetylase
type: DnaReference
organism: Escherichia coli