Reference/ChEBI CHEBI 16015
type: UnificationXref
id: CHEBI:16015
db: ChEBI

Reference/HMDB HMDB0062573
type: UnificationXref
id: HMDB0062573
db: HMDB

Reference/ChemSpider 388356
type: UnificationXref
id: 388356
db: ChemSpider

Reference/PubChem-compound 6022
type: UnificationXref
id: 6022
db: PubChem-compound

Protein/6361/Stoichiometry/2.0
type: Stoichiometry
physical entity: Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]
stoichiometric coefficient: 2.0

Phosphocarrier protein HPr
type: Protein
cellular location: Inner Membrane
entity reference: Phosphocarrier protein HPr

Acetyl-CoA
type: SmallMoleculeReference
xref: Reference/BioCyc ACETYL-COA
xref: Reference/PubChem-compound 444493
xref: Reference/HMDB HMDB0001206
xref: Reference/ChemSpider 392413
xref: Reference/CAS 72-89-9
xref: Reference/ChEBI CHEBI 15351
xref: Reference/KEGG Compound C00024
chemical formula: C23H38N7O17P3S
molecular weight: 809.1258
structure: ChemicalStructure/PW C000940

Reference/ChemSpider 937
type: UnificationXref
id: 937
db: ChemSpider

3-deoxy-D-manno-octulosonic-acid transferase
type: ProteinReference
xref: Reference/UniProt P0AC75

Lipopolysaccharide Biosynthesis II
type: Pathway
pathway order: PathwayEnzymeReaction/20013
pathway order: PathwayEnzymeReaction/20035
pathway order: PathwayEnzymeReaction/20011
pathway order: PathwayEnzymeReaction/20033
pathway order: PathwayEnzymeReaction/20034
pathway order: PathwayEnzymeReaction/20031
pathway order: PathwayEnzymeReaction/20032
pathway order: PathwayEnzymeReaction/20030
pathway order: PathwayEnzymeReaction/20074
pathway order: PathwayEnzymeReaction/20019
pathway order: PathwayEnzymeReaction/20017
pathway order: PathwayEnzymeReaction/20039
pathway order: PathwayEnzymeReaction/20018
pathway order: PathwayEnzymeReaction/20015
pathway order: PathwayEnzymeReaction/20037
pathway order: PathwayEnzymeReaction/20016
pathway order: PathwayEnzymeReaction/20038
pathway order: PathwaySubPathway/109920
pathway order: PathwaySubPathway/109919
pathway order: PathwayEnzymeReaction/2122975
pathway order: PathwayEnzymeReaction/2122976
pathway order: PathwayEnzymeReaction/2122977
pathway order: PathwayEnzymeReaction/2122978
pathway order: PathwayEnzymeReaction/2122979
pathway order: PathwayEnzymeReaction/20024
pathway order: PathwayEnzymeReaction/20025
pathway order: PathwayTransport/20043
pathway order: PathwayEnzymeReaction/20023
pathway order: PathwayEnzymeReaction/20020
pathway order: PathwayEnzymeReaction/20042
pathway order: PathwayEnzymeReaction/20041
pathway order: PathwayEnzymeReaction/20028
pathway order: PathwayEnzymeReaction/20029
pathway order: PathwayEnzymeReaction/20026
pathway order: PathwayEnzymeReaction/20027
pathway component: SubPathway
pathway component: 2.3.1.-
pathway component: Reaction3035
pathway component: 2.4.99.12
pathway component: 2.7.7.38
pathway component: 3.1.3.45
pathway component: 3.6.3.-
pathway component: 2.5.1.55
pathway component: 5.3.1.13
pathway component: 2.-.-.-
pathway component: Reaction3314
pathway component: 2.7.7.23
pathway component: 5.4.2.10
pathway component: Transport485
pathway component: 3.5.1.-
pathway component: 2.3.1.129
pathway component: ReactionCatalysis2987
pathway component: ReactionCatalysis2986
pathway component: ReactionCatalysis2989
pathway component: ReactionCatalysis2988
pathway component: ReactionCatalysis3276
pathway component: ReactionCatalysis3554
pathway component: 2.7.1.130
pathway component: 2.4.1.182
pathway component: ReactionCatalysis3277
pathway component: 3.6.1.54
pathway component: 2.3.1.191
pathway component: ReactionCatalysis3278
pathway component: Glycolysis and Pyruvate Dehydrogenase
pathway component: ReactionCoupledTransportCatalysis198
pathway component: ReactionCoupledTransportCatalysis150
pathway component: ReactionCatalysis2996
pathway component: ReactionCatalysis3008
pathway component: ReactionCatalysis2995
pathway component: ReactionCatalysis3009
pathway component: ReactionCatalysis3006
pathway component: ReactionCatalysis2998
pathway component: ReactionCatalysis2997
pathway component: ReactionCatalysis3007
pathway component: ReactionCatalysis2999
pathway component: TransportCatalysis417
pathway component: ReactionCatalysis3000

Reference/ChemSpider 559127
type: UnificationXref
id: 559127
db: ChemSpider

BiologicalState304
type: BioSource
xref: Reference/TAXONOMY 2
name: Bacteria

lipid A disaccharide
type: SmallMolecule
cellular location: Cytosol
entity reference: lipid A disaccharide

Reference/HMDB HMDB0000095
type: UnificationXref
id: HMDB0000095
db: HMDB

Reaction3314
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000196 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000192 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001055 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000170 Cytosol/Stoichiometry/1.0
right: Uridine diphosphate-N-acetylglucosamine
right: Pyrophosphate
spontaneous: false
left: Hydrogen Ion
left: Uridine triphosphate
left: N-Acetyl-glucosamine 1-phosphate
name: Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate + Uridine triphosphate → Pyrophosphate + Uridine diphosphate-N-acetylglucosamine
conversion direction: LEFT_TO_RIGHT

Compound/PW C040034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

2.7.7.23
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000868/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001099/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000940/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001055/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: N-Acetyl-glucosamine 1-phosphate
right: Coenzyme A
right: Hydrogen Ion
spontaneous: false
EC number: 2.7.7.23
left: Acetyl-CoA
left: Glucosamine-1P
name: Acetyl-CoA + Glucosamine-1P → Coenzyme A + Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate
conversion direction: LEFT_TO_RIGHT

5.4.2.10
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000868/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000969/Stoichiometry/1.0
right: Glucosamine-1P
spontaneous: false
EC number: 5.4.2.10
left: Glucosamine 6-phosphate
name: Glucosamine 6-phosphate ↔ Glucosamine-1P
conversion direction: REVERSIBLE

Reference/PubChem-compound 6133
type: UnificationXref
id: 6133
db: PubChem-compound

Reference/PubChem-compound 6131
type: UnificationXref
id: 6131
db: PubChem-compound

Glucosamine 6-phosphate
type: SmallMolecule
entity reference: Glucosamine 6-phosphate

Reference/UniProt P0AF98
type: UnificationXref
id: P0AF98
db: UniProt

Transport485
type: Transport
participant stoichiometry: Compound/PW C044492 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044492 Extracellular Space/Stoichiometry/1.0
right: phosphoethanolamine-Kdo2-lipid A
spontaneous: false
left: phosphoethanolamine-Kdo2-lipid A
name: phosphoethanolamine-Kdo2-lipid A (→) Transport: Escherichia coli, Cytosol to Escherichia coli, Extracellular Space
conversion direction: LEFT_TO_RIGHT

Compound/PW C000064/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine monophosphate
stoichiometric coefficient: 1.0

Reference/UniProt P0ADV9
type: UnificationXref
id: P0ADV9
db: UniProt

Lipopolysaccharide 1,2-glucosyltransferase
type: ProteinReference
xref: Reference/UniProt P27129

Reference/BioCyc ATP
type: UnificationXref
id: ATP
db: BioCyc

Lipid A biosynthesis lauroyl acyltransferase
type: ProteinReference
xref: Reference/UniProt P0ACV0

Reference/ChEBI CHEBI 16264
type: UnificationXref
id: CHEBI:16264
db: ChEBI

PTS system mannose-specific EIIAB component
type: ProteinReference
xref: Reference/UniProt P69797
organism: Escherichia coli

Compound/PW C040982 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: lipid IVA
stoichiometric coefficient: 1.0

Reference/PubChem-compound 644078
type: UnificationXref
id: 644078
db: PubChem-compound

Bifunctional protein glmU
type: ProteinReference
xref: Reference/UniProt P0ACC7

Reference/CAS 53188-23-1
type: UnificationXref
id: 53188-23-1
db: CAS

Compound/PW C000095/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamic acid
stoichiometric coefficient: 1.0

Protein/6627/Stoichiometry/4.0
type: Stoichiometry
physical entity: Arabinose 5-phosphate isomerase
stoichiometric coefficient: 4.0

Reference/UniProt P17115
type: UnificationXref
id: P17115
db: UniProt

Reference/ChemSpider 559142
type: UnificationXref
id: 559142
db: ChemSpider

Compound/PW C044492/Stoichiometry/1.0
type: Stoichiometry
physical entity: phosphoethanolamine-Kdo2-lipid A
stoichiometric coefficient: 1.0

ADP-L-glycero-β-D-manno-heptose
type: SmallMolecule
cellular location: Cytosol
entity reference: ADP-L-glycero-β-D-manno-heptose

Reference/UniProt P0ADV1
type: UnificationXref
id: P0ADV1
db: UniProt

Compound/PW C040763 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: ADP-L-glycero-β-D-manno-heptose
stoichiometric coefficient: 1.0

Reference/UniProt P0AA04
type: UnificationXref
id: P0AA04
db: UniProt

Compound/PW C044492 Extracellular Space/Stoichiometry/1.0
type: Stoichiometry
physical entity: phosphoethanolamine-Kdo2-lipid A
stoichiometric coefficient: 1.0

Compound/PW C001034/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 5746
type: UnificationXref
id: 5746
db: ChemSpider

Lipopolysaccharide export system protein lptC
type: ProteinReference
xref: Reference/UniProt P0ADV9

Reference/UniProt P31554
type: UnificationXref
id: P31554
db: UniProt

ReactionCoupledTransportCatalysis198
type: Catalysis
controller: mannose PTS permease
controlled: ReactionCoupledTransport164
control type: ACTIVATION

Phosphoethanolamine transferase eptB
type: Protein
entity reference: Phosphoethanolamine transferase eptB

Reference/ChemSpider 5742
type: UnificationXref
id: 5742
db: ChemSpider

Reference/PubChem-compound 439184
type: UnificationXref
id: 439184
db: PubChem-compound

Lipopolysaccharide core biosynthesis protein rfaG
type: Protein
entity reference: Lipopolysaccharide core biosynthesis protein rfaG

Tetraacyldisaccharide 4'-kinase
type: ProteinReference
xref: Reference/UniProt P27300
organism: BiologicalState304

Lipopolysaccharide core heptosyltransferase rfaQ
type: Protein
entity reference: Lipopolysaccharide core heptosyltransferase rfaQ

myristoyl-[acp]
type: Protein
entity reference: myristoyl-[acp]

ChemicalStructure/PW C003149
type: ChemicalStructure
structure format: SMILES

Protein/6400/Stoichiometry/3.0
type: Stoichiometry
physical entity: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
stoichiometric coefficient: 3.0

Compound/PW C040990/Stoichiometry/1.0
type: Stoichiometry
physical entity: glucosyl-(heptosyl)2-Kdo2-lipid A-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 8140645
type: UnificationXref
id: 8140645
db: ChemSpider

Reference/KEGG Compound C00229
type: UnificationXref
id: C00229
db: KEGG Compound

outer membrane lipopolysaccharide transport and assembly complex - LptD subunit
type: ProteinReference
xref: Reference/UniProt P31554

outer membrane lipopolysaccharide transport and assembly complex - LptE subunit
type: ProteinReference
xref: Reference/UniProt P0ADC1

ReactionCatalysis5270
type: Catalysis
controller: Phosphoethanolamine transferase eptB
controlled: Reaction5310
control type: ACTIVATION

Reference/KEGG Compound C00105
type: UnificationXref
id: C00105
db: KEGG Compound

Reference/PubChem-compound 53477679
type: UnificationXref
id: 53477679
db: PubChem-compound

Reference/PubChem-compound 6030
type: UnificationXref
id: 6030
db: PubChem-compound

Reference/CAS 133-89-1
type: UnificationXref
id: 133-89-1
db: CAS

Lipopolysaccharide core heptose(I) kinase rfaP
type: Protein
entity reference: Lipopolysaccharide core heptose(I) kinase rfaP

(3R)-3-hydroxymyristoyl-[acp]
type: Protein
entity reference: (3R)-3-hydroxymyristoyl-[acp]

Acetyl-CoA
type: SmallMolecule
entity reference: Acetyl-CoA

Lipopolysaccharide 1,6-galactosyltransferase
type: Protein
entity reference: Lipopolysaccharide 1,6-galactosyltransferase

ADP-heptose--LPS heptosyltransferase 2
type: Protein
entity reference: ADP-heptose--LPS heptosyltransferase 2

Reference/ChEBI CHEBI 16241
type: UnificationXref
id: CHEBI:16241
db: ChEBI

Reference/ChemSpider 1010
type: UnificationXref
id: 1010
db: ChemSpider

ChemicalStructure/PW C001099
type: ChemicalStructure
structure format: SMILES

Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]
type: ProteinReference
xref: Reference/UniProt P17169

3-deoxy-manno-octulosonate cytidylyltransferase
type: Protein
entity reference: 3-deoxy-manno-octulosonate cytidylyltransferase

Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
type: Protein
entity reference: Lipopolysaccharide 1,2-N-acetylglucosaminetransferase

Lipopolysaccharide core heptose(II) kinase rfaY
type: Protein
entity reference: Lipopolysaccharide core heptose(II) kinase rfaY

Reference/BioCyc PPI
type: UnificationXref
id: PPI
db: BioCyc

Reference/BioCyc GLUCOSAMINE-1P
type: UnificationXref
id: GLUCOSAMINE-1P
db: BioCyc

Reference/PubChem-compound 440272
type: UnificationXref
id: 440272
db: PubChem-compound

Reference/UniProt P0ACV0
type: UnificationXref
id: P0ACV0
db: UniProt

Reference/ChEBI CHEBI 237189
type: UnificationXref
id: CHEBI:237189
db: ChEBI

Reference/CAS 63-37-6
type: UnificationXref
id: 63-37-6
db: CAS

Reaction3565
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000095/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000500/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000969/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000079/Stoichiometry/1.0
right: L-Glutamic acid
right: Glucosamine 6-phosphate
spontaneous: false
left: Fructose 6-phosphate
left: L-Glutamine
name: Fructose 6-phosphate + L-Glutamine → Glucosamine 6-phosphate + L-Glutamic acid
conversion direction: LEFT_TO_RIGHT

Reference/CAS 138-08-9
type: UnificationXref
id: 138-08-9
db: CAS

Compound/PW C040994/Stoichiometry/1.0
type: Stoichiometry
physical entity: galactosyl-glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate
stoichiometric coefficient: 1.0

Glucosamine-1P
type: SmallMoleculeReference
xref: Reference/PubChem-compound 9965052
xref: Reference/BioCyc GLUCOSAMINE-1P
xref: Reference/HMDB HMDB0001109
xref: Reference/ChemSpider 8140645
chemical formula: C6H14NO8P
molecular weight: 259.04572
structure: ChemicalStructure/PW C000868

Compound/PW C000192 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine triphosphate
stoichiometric coefficient: 1.0

Protein/7292/Stoichiometry/2.0
type: Stoichiometry
physical entity: Lipopolysaccharide export system ATP-binding protein lptB
stoichiometric coefficient: 2.0

Compound/PW C000868/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosamine-1P
stoichiometric coefficient: 1.0

heptosyl-Kdo2-lipid A
type: SmallMolecule
cellular location: Cytosol
entity reference: heptosyl-Kdo2-lipid A

Compound/PW C000414 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
entity reference: Hydrogen Ion

L-Glutamine
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000641
xref: Reference/ChEBI CHEBI 18050
xref: Reference/ChemSpider 5746
xref: Reference/BioCyc GLN
xref: Reference/KEGG Compound C00064
xref: Reference/PubChem-compound 5961
xref: Reference/CAS 56-85-9
chemical formula: C5H10N2O3
molecular weight: 146.06914
structure: ChemicalStructure/PW C000500

Reference/KEGG Compound C00352
type: UnificationXref
id: C00352
db: KEGG Compound

Cytosol
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005829

Compound/PW C000064 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine monophosphate
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00350
type: UnificationXref
id: C00350
db: KEGG Compound

Compound/PW C000170 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 73005
type: UnificationXref
id: CHEBI:73005
db: ChEBI

Adenosine triphosphate
type: SmallMolecule
entity reference: Adenosine triphosphate

3.6.3.-
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040997 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104 Inner Membrane/Stoichiometry/1.0
right: Phosphate
right: lipid A-core
right: Adenosine diphosphate
right: Hydrogen Ion
spontaneous: false
EC number: 3.6.3.-
left: Water
left: lipid A-core
left: Adenosine triphosphate
name: lipid A-core + Adenosine triphosphate + Water → lipid A-core + Adenosine diphosphate + Hydrogen Ion + Phosphate
conversion direction: LEFT_TO_RIGHT

Protein/7147 Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: Mannose permease IID component
stoichiometric coefficient: 2.0

Reference/KEGG Compound C00009
type: UnificationXref
id: C00009
db: KEGG Compound

Reference/ChEBI CHEBI 62000
type: UnificationXref
id: CHEBI:62000
db: ChEBI

D-Fructose
type: SmallMoleculeReference
xref: Reference/BioCyc CPD-535
xref: Reference/ChEBI CHEBI 28645
xref: Reference/ChemSpider 388775
xref: Reference/PubChem-compound 439709
xref: Reference/KEGG Compound C02336
xref: Reference/HMDB HMDB0000660
xref: Reference/CAS 53188-23-1
chemical formula: C6H12O6
molecular weight: 180.06339
structure: ChemicalStructure/PW C000517

Reference/KEGG Compound C00008
type: UnificationXref
id: C00008
db: KEGG Compound

Reference/ChEBI CHEBI 62001
type: UnificationXref
id: CHEBI:62001
db: ChEBI

Reference/CAS 3616-42-0
type: UnificationXref
id: 3616-42-0
db: CAS

Compound/PW C000500/Stoichiometry/1.0
type: Stoichiometry
physical entity: L-Glutamine
stoichiometric coefficient: 1.0

Compound/PW C040978/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine
stoichiometric coefficient: 1.0

Hydrogen Ion
type: SmallMolecule
cellular location: Cytosol
entity reference: Hydrogen Ion

Compound/PW C040740/Stoichiometry/1.0
type: Stoichiometry
physical entity: (KDO)2-lipid A
stoichiometric coefficient: 1.0

Reference/KEGG Compound C00001
type: UnificationXref
id: C00001
db: KEGG Compound

Arabinose 5-phosphate isomerase
type: Protein
entity reference: Arabinose 5-phosphate isomerase

Reference/BioCyc CTP
type: UnificationXref
id: CTP
db: BioCyc

Reference/ChEBI CHEBI 16064
type: UnificationXref
id: CHEBI:16064
db: ChEBI

Reference/ChEBI CHEBI 18361
type: UnificationXref
id: CHEBI:18361
db: ChEBI

Lipopolysaccharide export system protein lptA
type: ProteinReference
xref: Reference/UniProt P0ADV1

SubPathwayInteraction109919
type: Interaction
name: SubPathwayReaction
name: SubPathway109919Reaction
participant: Fructose 6-phosphate

Reference/ChEBI CHEBI 18367
type: UnificationXref
id: CHEBI:18367
db: ChEBI

Reference/ChemSpider 1032
type: UnificationXref
id: 1032
db: ChemSpider

Reference/KEGG Compound C00002
type: UnificationXref
id: C00002
db: KEGG Compound

Phosphocarrier protein HPr
type: ProteinReference
xref: Reference/UniProt P0AA04
organism: Escherichia coli

2-dehydro-3-deoxyphosphooctonate aldolase
type: ProteinReference
xref: Reference/UniProt P0A715

Phosphoglucosamine mutase
type: Protein
entity reference: Phosphoglucosamine mutase

ReactionCatalysis3276
type: Catalysis
controller: Phosphoglucosamine mutase
controlled: 5.4.2.10
control type: ACTIVATION

SubPathwayInteraction109920
type: Interaction
name: SubPathway109920Reaction
name: SubPathwayReaction
participant: D-Ribulose 5-phosphate

ReactionCatalysis3277
type: Catalysis
controller: fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
controlled: 2.7.7.23
control type: ACTIVATION

ReactionCatalysis3278
type: Catalysis
controller: fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
controlled: Reaction3314
control type: ACTIVATION

UDP-2,3-diacylglucosamine hydrolase
type: Protein
cellular location: Cytosol
entity reference: UDP-2,3-diacylglucosamine hydrolase

Compound/PW C040991/Stoichiometry/1.0
type: Stoichiometry
physical entity: glucosyl-(heptosyl)3-Kdo2-lipid A-phosphate
stoichiometric coefficient: 1.0

Glycolysis and Pyruvate Dehydrogenase
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109919
pathway component: SubPathwayInteraction109919
xref: Reference/PathWhiz PW000785
xref: Reference/SMPDB SMP0000807
name: SubPathway

Reference/ChemSpider 388775
type: UnificationXref
id: 388775
db: ChemSpider

Reference/ChEBI CHEBI 17361
type: UnificationXref
id: CHEBI:17361
db: ChEBI

Reference/KEGG Compound C00010
type: UnificationXref
id: C00010
db: KEGG Compound

UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
type: ProteinReference
xref: Reference/UniProt P0A725

Reference/BioCyc FRUCTOSE-6P
type: UnificationXref
id: FRUCTOSE-6P
db: BioCyc

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
type: ProteinReference
xref: Reference/UniProt P0A722

ReactionCoupledTransportCatalysis150
type: Catalysis
controller: Lipid A export ATP-binding/permease protein msbA
controlled: 3.6.3.-
control type: ACTIVATION

Reference/ChEBI CHEBI 17363
type: UnificationXref
id: CHEBI:17363
db: ChEBI

Reference/KEGG Compound C00013
type: UnificationXref
id: C00013
db: KEGG Compound

Glucosamine 6-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 3616-42-0
xref: Reference/ChemSpider 388356
xref: Reference/ChEBI CHEBI 15873
xref: Reference/KEGG Compound C00352
xref: Reference/BioCyc D-GLUCOSAMINE-6-P
xref: Reference/PubChem-compound 439217
xref: Reference/HMDB HMDB0001254
chemical formula: C6H14NO8P
molecular weight: 259.04572
structure: ChemicalStructure/PW C000969

Extracellular Space
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0005615

Reference/ChEBI CHEBI 7125
type: UnificationXref
id: CHEBI:7125
db: ChEBI

ChemicalStructure/PW C007308
type: ChemicalStructure
structure format: SMILES
structure data: O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)C=O

Protein gutQ
type: ProteinReference
xref: Reference/UniProt P17115

Reference/BioCyc D-GLUCOSAMINE-6-P
type: UnificationXref
id: D-GLUCOSAMINE-6-P
db: BioCyc

Compound/PW C001055 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-glucosamine 1-phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 62004
type: UnificationXref
id: CHEBI:62004
db: ChEBI

Reaction5310
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040736/Stoichiometry/1.0
participant stoichiometry: Compound/PW C003149/Stoichiometry/1.0
participant stoichiometry: Compound/PW C044492/Stoichiometry/1.0
participant stoichiometry: Compound/PW C004971/Stoichiometry/1.0
right: DG(16:0/16:0)
right: phosphoethanolamine-Kdo2-lipid A
spontaneous: false
left: PE(16:0/16:0)
left: a-Kdo-(2->4)-a-Kdo-(2->6)-lipid IVA
name: PE(16:0/16:0) + a-Kdo-(2->4)-a-Kdo-(2->6)-lipid IVA → DG(16:0/16:0) + phosphoethanolamine-Kdo2-lipid A
conversion direction: LEFT_TO_RIGHT

Reference/TAXONOMY 562
type: UnificationXref
id: 562
db: TAXONOMY

Reference/ChEBI CHEBI 62002
type: UnificationXref
id: CHEBI:62002
db: ChEBI

Reference/ChEBI CHEBI 62003
type: UnificationXref
id: CHEBI:62003
db: ChEBI

Hydrogen Ion
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00080
xref: Reference/ChEBI CHEBI 15378
xref: Reference/HMDB HMDB0059597
xref: Reference/PubChem-compound 1038
xref: Reference/ChemSpider 1010
chemical formula: H
molecular weight: 1.007825
structure: ChemicalStructure/PW C040034

Reference/UniProt P27242
type: UnificationXref
id: P27242
db: UniProt

Reference/KEGG Compound C00029
type: UnificationXref
id: C00029
db: KEGG Compound

Reference/UniProt P27127
type: UnificationXref
id: P27127
db: UniProt

Reference/KEGG Compound C01112
type: UnificationXref
id: C01112
db: KEGG Compound

L-Glutamine
type: SmallMolecule
entity reference: L-Glutamine

Reference/CAS 56-65-5
type: UnificationXref
id: 56-65-5
db: CAS

Glucosamine-1P
type: SmallMolecule
entity reference: Glucosamine-1P

Reference/KEGG Compound C00025
type: UnificationXref
id: C00025
db: KEGG Compound

Reference/UniProt P27240
type: UnificationXref
id: P27240
db: UniProt

Reference/ChemSpider 62713
type: UnificationXref
id: 62713
db: ChemSpider

Reference/KEGG Compound C00024
type: UnificationXref
id: C00024
db: KEGG Compound

Compound/PW C003149/Stoichiometry/1.0
type: Stoichiometry
physical entity: DG(16:0/16:0)
stoichiometric coefficient: 1.0

Reference/BioCyc ACET
type: UnificationXref
id: ACET
db: BioCyc

Lipopolysaccharide 1,3-galactosyltransferase
type: ProteinReference
xref: Reference/UniProt P27128

UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
type: Protein
entity reference: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Compound/PW C000193/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate glucose
stoichiometric coefficient: 1.0

Reference/UniProt P27128
type: UnificationXref
id: P27128
db: UniProt

Reference/UniProt P27129
type: UnificationXref
id: P27129
db: UniProt

ChemicalStructure/PW C040983
type: ChemicalStructure
structure format: SMILES
structure data: OC(COP([O-])([O-])=O)C(O)C(O)C(O)CC(=O)C([O-])=O

ChemicalStructure/PW C040982
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040740
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040981
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040980
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc DIACYLGLYCEROL
type: UnificationXref
id: DIACYLGLYCEROL
db: BioCyc

ChemicalStructure/PW C040987
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040986
type: ChemicalStructure
structure format: SMILES

CMP-3-deoxy-α-D-manno-octulosonate
type: SmallMolecule
cellular location: Cytosol
entity reference: CMP-3-deoxy-α-D-manno-octulosonate

ChemicalStructure/PW C040985
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040984
type: ChemicalStructure
structure format: SMILES
structure data: OCC(O)C(O)C(O)C(O)CC(=O)C([O-])=O

Reference/KEGG Compound C00033
type: UnificationXref
id: C00033
db: KEGG Compound

Compound/PW C040997 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: lipid A-core
stoichiometric coefficient: 1.0

ChemicalStructure/PW C040989
type: ChemicalStructure
structure format: SMILES

Lipid A export ATP-binding/permease protein msbA
type: ProteinReference
xref: Reference/UniProt P60752
organism: Escherichia coli

Reference/KEGG Compound C02336
type: UnificationXref
id: C02336
db: KEGG Compound

ChemicalStructure/PW C040988
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-1-P
type: UnificationXref
id: N-ACETYL-D-GLUCOSAMINE-1-P
db: BioCyc

Reference/ChemSpider 163687
type: UnificationXref
id: 163687
db: ChemSpider

Reference/SMPDB SMP0000807
type: UnificationXref
id: SMP0000807
db: SMPDB

2.3.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040736/Stoichiometry/1.0
participant stoichiometry: Protein/Generic176/Stoichiometry/1.0
participant stoichiometry: Compound/Generic86/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040739/Stoichiometry/1.0
right: a holo-[acyl-carrier protein]
right: (KDO)2-(lauroyl)-lipid IVA
spontaneous: false
EC number: 2.3.1.-
left: dodecanoyl-[acp]
left: a-Kdo-(2->4)-a-Kdo-(2->6)-lipid IVA
name: a-Kdo-(2->4)-a-Kdo-(2->6)-lipid IVA + dodecanoyl-[acp] → (KDO)2-(lauroyl)-lipid IVA + a holo-[acyl-carrier protein]
conversion direction: LEFT_TO_RIGHT

Reaction3035
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040986 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040985 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040736 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000064 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: a-Kdo-(2->4)-a-Kdo-(2->6)-lipid IVA
right: Cytidine monophosphate
spontaneous: false
left: CMP-3-deoxy-α-D-manno-octulosonate
left: α-Kdo-(2→6)-lipid IVA
name: CMP-3-deoxy-α-D-manno-octulosonate + α-Kdo-(2→6)-lipid IVA → Cytidine monophosphate + Hydrogen Ion + a-Kdo-(2->4)-a-Kdo-(2->6)-lipid IVA
conversion direction: LEFT_TO_RIGHT

Water
type: SmallMolecule
entity reference: Water

2.4.99.12
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040986/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000064/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040985/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040982/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Cytidine monophosphate
right: Hydrogen Ion
right: α-Kdo-(2→6)-lipid IVA
spontaneous: false
EC number: 2.4.99.12
left: lipid IVA
left: CMP-3-deoxy-α-D-manno-octulosonate
name: CMP-3-deoxy-α-D-manno-octulosonate + lipid IVA → Cytidine monophosphate + Hydrogen Ion + α-Kdo-(2→6)-lipid IVA
conversion direction: LEFT_TO_RIGHT

2.7.7.38
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000170/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000057/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040985/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040984/Stoichiometry/1.0
right: CMP-3-deoxy-α-D-manno-octulosonate
right: Pyrophosphate
spontaneous: false
EC number: 2.7.7.38
left: 3-deoxy-D-manno-octulosonate
left: Cytidine triphosphate
name: 3-deoxy-D-manno-octulosonate + Cytidine triphosphate → CMP-3-deoxy-α-D-manno-octulosonate + Pyrophosphate
conversion direction: LEFT_TO_RIGHT

Reference/ChEBI CHEBI 58603
type: UnificationXref
id: CHEBI:58603
db: ChEBI

lipopolysaccharide transport system
type: Complex
component stoichiometry: Protein/7292/Stoichiometry/2.0
component: Lipopolysaccharide export system permease protein lptG
component: Lipopolysaccharide export system protein lptA
component: Lipopolysaccharide export system ATP-binding protein lptB
component: outer membrane lipopolysaccharide transport and assembly complex - LptD subunit
component: Lipopolysaccharide export system protein lptC
component: Lipopolysaccharide export system permease protein lptF
component: outer membrane lipopolysaccharide transport and assembly complex - LptE subunit

3.1.3.45
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040984/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040983/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
right: 3-deoxy-D-manno-octulosonate
right: Phosphate
spontaneous: false
EC number: 3.1.3.45
left: 3-deoxy-D-manno-octulosonate 8-phosphate
left: Water
name: 3-deoxy-D-manno-octulosonate 8-phosphate + Water → 3-deoxy-D-manno-octulosonate + Phosphate
conversion direction: LEFT_TO_RIGHT

Reference/UniProt P0A722
type: UnificationXref
id: P0A722
db: UniProt

2.5.1.55
type: BiochemicalReaction
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000180/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007308/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001104/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040983/Stoichiometry/1.0
right: 3-deoxy-D-manno-octulosonate 8-phosphate
right: Phosphate
spontaneous: false
EC number: 2.5.1.55
left: Water
left: Phosphoenolpyruvic acid
left: D-Arabinose 5-phosphate
name: D-Arabinose 5-phosphate + Phosphoenolpyruvic acid + Water → 3-deoxy-D-manno-octulosonate 8-phosphate + Phosphate
conversion direction: LEFT_TO_RIGHT

5.3.1.13
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000479/Stoichiometry/1.0
participant stoichiometry: Compound/PW C007308/Stoichiometry/1.0
right: D-Arabinose 5-phosphate
spontaneous: false
EC number: 5.3.1.13
left: D-Ribulose 5-phosphate
name: D-Ribulose 5-phosphate → D-Arabinose 5-phosphate
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000057
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P0A725
type: UnificationXref
id: P0A725
db: UniProt

phosphoethanolamine-Kdo2-lipid A
type: SmallMoleculeReference
xref: Reference/PubChem-compound 46173153
chemical formula: C112H199N3O42P3
molecular weight: 2351.2773
structure: ChemicalStructure/PW C044492

ChemicalStructure/PW C040990
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0000250
type: UnificationXref
id: HMDB0000250
db: HMDB

2.-.-.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040988/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040763/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040987/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: (heptosyl)2-Kdo2-lipid A
spontaneous: false
EC number: 2.-.-.-
left: ADP-L-glycero-β-D-manno-heptose
left: heptosyl-Kdo2-lipid A
name: ADP-L-glycero-β-D-manno-heptose + heptosyl-Kdo2-lipid A → (heptosyl)2-Kdo2-lipid A + Adenosine diphosphate + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000170
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(=O)OP(O)(O)=O

2.-.-.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040740 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040987 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040763 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: heptosyl-Kdo2-lipid A
right: Adenosine diphosphate
right: Hydrogen Ion
spontaneous: false
EC number: 2.-.-.-
left: (KDO)2-lipid A
left: ADP-L-glycero-β-D-manno-heptose
name: (KDO)2-lipid A + ADP-L-glycero-β-D-manno-heptose → Adenosine diphosphate + Hydrogen Ion + heptosyl-Kdo2-lipid A
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0001341
type: UnificationXref
id: HMDB0001341
db: HMDB

2.3.1.-
type: BiochemicalReaction
participant stoichiometry: Protein/Generic186/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040740/Stoichiometry/1.0
participant stoichiometry: Compound/Generic86/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040739/Stoichiometry/1.0
right: (KDO)2-lipid A
right: a holo-[acyl-carrier protein]
spontaneous: false
EC number: 2.3.1.-
left: (KDO)2-(lauroyl)-lipid IVA
left: myristoyl-[acp]
name: myristoyl-[acp] + (KDO)2-(lauroyl)-lipid IVA → (KDO)2-lipid A + a holo-[acyl-carrier protein]
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C040994
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040993
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040992
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040991
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P27300
type: UnificationXref
id: P27300
db: UniProt

ChemicalStructure/PW C040997
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040996
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040995
type: ChemicalStructure
structure format: SMILES

Reference/HMDB HMDB0001109
type: UnificationXref
id: HMDB0001109
db: HMDB

Reference/KEGG Compound C00165
type: UnificationXref
id: C00165
db: KEGG Compound

Reference/KEGG Compound C00043
type: UnificationXref
id: C00043
db: KEGG Compound

Mannose permease IID component
type: ProteinReference
xref: Reference/UniProt P69805
organism: Escherichia coli

Mannose permease IIC component
type: ProteinReference
xref: Reference/UniProt P69801
organism: Escherichia coli

Reference/CAS 56-85-9
type: UnificationXref
id: 56-85-9
db: CAS

3.5.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000029/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040976/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040977/Stoichiometry/1.0
right: UDP-3-O-(3-hydroxymyristoyl)-α-D-glucosamine
right: Acetic acid
spontaneous: false
EC number: 3.5.1.-
left: Water
left: UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-α-D-glucosamine
name: UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-α-D-glucosamine + Water → Acetic acid + UDP-3-O-(3-hydroxymyristoyl)-α-D-glucosamine
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C001034
type: ChemicalStructure
structure format: SMILES

Reference/CAS 58-97-9
type: UnificationXref
id: 58-97-9
db: CAS

2.3.1.129
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000196/Stoichiometry/1.0
participant stoichiometry: Compound/Generic86/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040976/Stoichiometry/1.0
participant stoichiometry: Protein/Generic191/Stoichiometry/1.0
right: a holo-[acyl-carrier protein]
right: UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-α-D-glucosamine
spontaneous: false
EC number: 2.3.1.129
left: Uridine diphosphate-N-acetylglucosamine
left: (3R)-3-hydroxymyristoyl-[acp]
name: (3R)-3-hydroxymyristoyl-[acp] + Uridine diphosphate-N-acetylglucosamine → UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-α-D-glucosamine + a holo-[acyl-carrier protein]
conversion direction: LEFT_TO_RIGHT

ChemicalStructure/PW C000064
type: ChemicalStructure
structure format: SMILES

Compound/PW C000170/Stoichiometry/1.0
type: Stoichiometry
physical entity: Pyrophosphate
stoichiometric coefficient: 1.0

Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
type: UnificationXref
id: PHOSPHO-ENOL-PYRUVATE
db: BioCyc

Reference/HMDB HMDB0000148
type: UnificationXref
id: HMDB0000148
db: HMDB

Lipid-A-disaccharide synthase
type: Protein
entity reference: Lipid-A-disaccharide synthase

2.7.1.130
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040982 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040981 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034 Cytosol/Stoichiometry/1.0
right: lipid IVA
right: Adenosine diphosphate
right: Hydrogen Ion
spontaneous: false
EC number: 2.7.1.130
left: lipid A disaccharide
left: Adenosine triphosphate
name: Adenosine triphosphate + lipid A disaccharide → Adenosine diphosphate + Hydrogen Ion + lipid IVA
conversion direction: LEFT_TO_RIGHT

2.4.1.182
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040981/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040978/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040979/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040980/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: UDP
right: Hydrogen Ion
right: lipid A disaccharide
spontaneous: false
EC number: 2.4.1.182
left: 2,3-bis[(3R)-3-hydroxymyristoyl]-α-D-glucosaminyl 1-phosphate
left: UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine
name: 2,3-bis[(3R)-3-hydroxymyristoyl]-α-D-glucosaminyl 1-phosphate + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine → Hydrogen Ion + UDP + lipid A disaccharide
conversion direction: LEFT_TO_RIGHT

3.6.1.54
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000194 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040978 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001420 Cytosol/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040979 Cytosol/Stoichiometry/1.0
right: Hydrogen Ion
right: 2,3-bis[(3R)-3-hydroxymyristoyl]-α-D-glucosaminyl 1-phosphate
right: Uridine 5'-monophosphate
spontaneous: false
EC number: 3.6.1.54
left: UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine
left: Water
name: UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine + Water → 2,3-bis[(3R)-3-hydroxymyristoyl]-α-D-glucosaminyl 1-phosphate + Hydrogen Ion + Uridine 5'-monophosphate
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000263
type: UnificationXref
id: HMDB0000263
db: HMDB

ChemicalStructure/PW C000180
type: ChemicalStructure
structure format: SMILES
structure data: OC(=O)C(=C)OP(O)(O)=O

2.3.1.191
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040978/Stoichiometry/1.0
participant stoichiometry: Compound/Generic86/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040977/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Protein/Generic191/Stoichiometry/1.0
right: a holo-[acyl-carrier protein]
right: Hydrogen Ion
right: UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine
spontaneous: false
EC number: 2.3.1.191
left: (3R)-3-hydroxymyristoyl-[acp]
left: UDP-3-O-(3-hydroxymyristoyl)-α-D-glucosamine
name: (3R)-3-hydroxymyristoyl-[acp] + UDP-3-O-(3-hydroxymyristoyl)-α-D-glucosamine → Hydrogen Ion + UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine + a holo-[acyl-carrier protein]
conversion direction: LEFT_TO_RIGHT

Reference/BioCyc UTP
type: UnificationXref
id: UTP
db: BioCyc

ChemicalStructure/PW C040763
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 5901
type: UnificationXref
id: 5901
db: ChemSpider

Reference/ChemSpider 5903
type: UnificationXref
id: 5903
db: ChemSpider

ChemicalStructure/PW C000029
type: ChemicalStructure
structure format: SMILES
structure data: CC(O)=O

Reference/KEGG Compound C00055
type: UnificationXref
id: C00055
db: KEGG Compound

Reference/SMPDB SMP0001919
type: UnificationXref
id: SMP0001919
db: SMPDB

Reference/CAS 7732-18-5
type: UnificationXref
id: 7732-18-5
db: CAS

Reference/ChEBI CHEBI 18014
type: UnificationXref
id: CHEBI:18014
db: ChEBI

Compound/PW C040977/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-3-O-(3-hydroxymyristoyl)-α-D-glucosamine
stoichiometric coefficient: 1.0

Lipopolysaccharide export system permease protein lptG
type: ProteinReference
xref: Reference/UniProt P0ADC6

Compound/PW C040997/Stoichiometry/1.0
type: Stoichiometry
physical entity: lipid A-core
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0001367
type: UnificationXref
id: HMDB0001367
db: HMDB

Reference/KEGG Compound C00063
type: UnificationXref
id: C00063
db: KEGG Compound

Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase
type: Protein
entity reference: Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase

3-deoxy-D-manno-octulosonate 8-phosphate phosphatase
type: ProteinReference
xref: Reference/UniProt P0ABZ4

Reference/CAS 56-86-0
type: UnificationXref
id: 56-86-0
db: CAS

Compound/PW C000079 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 6-phosphate
stoichiometric coefficient: 1.0

Compound/PW C000029/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetic acid
stoichiometric coefficient: 1.0

Adenosine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15422
xref: Reference/PubChem-compound 5957
xref: Reference/HMDB HMDB0000538
xref: Reference/CAS 56-65-5
xref: Reference/ChemSpider 5742
xref: Reference/BioCyc ATP
xref: Reference/KEGG Compound C00002
chemical formula: C10H16N5O13P3
molecular weight: 506.99576
structure: ChemicalStructure/PW C000414

Reference/PubChem-compound 445675
type: UnificationXref
id: 445675
db: PubChem-compound

Reference/KEGG Compound C00064
type: UnificationXref
id: C00064
db: KEGG Compound

Reference/CAS 6866-69-9
type: UnificationXref
id: 6866-69-9
db: CAS

Protein/7464 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphocarrier protein HPr
stoichiometric coefficient: 1.0

Reference/UniProt P24173
type: UnificationXref
id: P24173
db: UniProt

2.4.1.56
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040996/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040763/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040997/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: lipid A-core
spontaneous: false
EC number: 2.4.1.56
left: ADP-L-glycero-β-D-manno-heptose
left: galactosyl-(glucosyl)3-(heptosyl)3-Kdo2-lipid A-bisphosphate
name: ADP-L-glycero-β-D-manno-heptose + galactosyl-(glucosyl)3-(heptosyl)3-Kdo2-lipid A-bisphosphate → lipid A-core + Adenosine diphosphate + Hydrogen Ion
conversion direction: LEFT_TO_RIGHT

Reference/HMDB HMDB0000288
type: UnificationXref
id: HMDB0000288
db: HMDB

2.4.1.58
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040996/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000193/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040995/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040980/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: galactosyl-(glucosyl)3-(heptosyl)3-Kdo2-lipid A-bisphosphate
right: UDP
right: Hydrogen Ion
spontaneous: false
EC number: 2.4.1.58
left: galactosyl-(glucosyl)2-(heptosyl)3-Kdo2-lipid A-bisphosphate
left: Uridine diphosphate glucose
name: Uridine diphosphate glucose + galactosyl-(glucosyl)2-(heptosyl)3-Kdo2-lipid A-bisphosphate → Hydrogen Ion + UDP + galactosyl-(glucosyl)3-(heptosyl)3-Kdo2-lipid A-bisphosphate
conversion direction: LEFT_TO_RIGHT

Lipopolysaccharide export system permease protein lptF
type: ProteinReference
xref: Reference/UniProt P0AF98

Reference/CAS 65-47-4
type: UnificationXref
id: 65-47-4
db: CAS

2.4.1.44
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040994/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000193/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040995/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040980/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: galactosyl-(glucosyl)2-(heptosyl)3-Kdo2-lipid A-bisphosphate
right: UDP
right: Hydrogen Ion
spontaneous: false
EC number: 2.4.1.44
left: galactosyl-glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate
left: Uridine diphosphate glucose
name: Uridine diphosphate glucose + galactosyl-glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate → Hydrogen Ion + UDP + galactosyl-(glucosyl)2-(heptosyl)3-Kdo2-lipid A-bisphosphate
conversion direction: LEFT_TO_RIGHT

2.4.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040994/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040992/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040993/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040980/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: galactosyl-glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate
right: UDP
right: Hydrogen Ion
spontaneous: false
EC number: 2.4.1.-
left: UDP-α-D-galactose
left: glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate
name: UDP-α-D-galactose + glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate → Hydrogen Ion + UDP + galactosyl-glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate
conversion direction: LEFT_TO_RIGHT

Reference/KEGG Compound C00074
type: UnificationXref
id: C00074
db: KEGG Compound

2.7.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040991/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040992/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate
spontaneous: false
EC number: 2.7.1.-
left: glucosyl-(heptosyl)3-Kdo2-lipid A-phosphate
left: Adenosine triphosphate
name: Adenosine triphosphate + glucosyl-(heptosyl)3-Kdo2-lipid A-phosphate → Adenosine diphosphate + Hydrogen Ion + glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate
conversion direction: LEFT_TO_RIGHT

2.-.-.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040991/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040763/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040990/Stoichiometry/1.0
right: Adenosine diphosphate
right: Hydrogen Ion
right: glucosyl-(heptosyl)3-Kdo2-lipid A-phosphate
spontaneous: false
EC number: 2.-.-.-
left: ADP-L-glycero-β-D-manno-heptose
left: glucosyl-(heptosyl)2-Kdo2-lipid A-phosphate
name: ADP-L-glycero-β-D-manno-heptose + glucosyl-(heptosyl)2-Kdo2-lipid A-phosphate → Adenosine diphosphate + Hydrogen Ion + glucosyl-(heptosyl)3-Kdo2-lipid A-phosphate
conversion direction: LEFT_TO_RIGHT

Bifunctional protein glmU
type: Protein
cellular location: Cytosol
entity reference: Bifunctional protein glmU

2.7.1.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C000414/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040989/Stoichiometry/1.0
participant stoichiometry: Compound/PW C001034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040990/Stoichiometry/1.0
right: Adenosine diphosphate
right: glucosyl-(heptosyl)2-Kdo2-lipid A-phosphate
right: Hydrogen Ion
spontaneous: false
EC number: 2.7.1.-
left: glucosyl-(heptosyl)2-Kdo2-lipid A
left: Adenosine triphosphate
name: Adenosine triphosphate + glucosyl-(heptosyl)2-Kdo2-lipid A → Adenosine diphosphate + Hydrogen Ion + glucosyl-(heptosyl)2-Kdo2-lipid A-phosphate
conversion direction: LEFT_TO_RIGHT

Lipopolysaccharide export system ATP-binding protein lptB
type: ProteinReference
xref: Reference/UniProt P0A9V1

3-deoxy-D-manno-octulosonic-acid transferase
type: Protein
entity reference: 3-deoxy-D-manno-octulosonic-acid transferase

2.4.-.-
type: BiochemicalReaction
participant stoichiometry: Compound/PW C040988/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040989/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000193/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040980/Stoichiometry/1.0
participant stoichiometry: Compound/PW C040034/Stoichiometry/1.0
right: UDP
right: Hydrogen Ion
right: glucosyl-(heptosyl)2-Kdo2-lipid A
spontaneous: false
EC number: 2.4.-.-
left: Uridine diphosphate glucose
left: (heptosyl)2-Kdo2-lipid A
name: (heptosyl)2-Kdo2-lipid A + Uridine diphosphate glucose → Hydrogen Ion + UDP + glucosyl-(heptosyl)2-Kdo2-lipid A
conversion direction: LEFT_TO_RIGHT

Compound/PW C040995/Stoichiometry/1.0
type: Stoichiometry
physical entity: galactosyl-(glucosyl)2-(heptosyl)3-Kdo2-lipid A-bisphosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0000042
type: UnificationXref
id: HMDB0000042
db: HMDB

Reference/HMDB HMDB0000286
type: UnificationXref
id: HMDB0000286
db: HMDB

Reference/HMDB HMDB0001254
type: UnificationXref
id: HMDB0001254
db: HMDB

Reference/HMDB HMDB0000285
type: UnificationXref
id: HMDB0000285
db: HMDB

Reference/PubChem-compound 962
type: UnificationXref
id: 962
db: PubChem-compound

Reference/BioCyc RIBULOSE-5P
type: UnificationXref
id: RIBULOSE-5P
db: BioCyc

Reference/ChemSpider 5800
type: UnificationXref
id: 5800
db: ChemSpider

Reference/KEGG Compound C00199
type: UnificationXref
id: C00199
db: KEGG Compound

Lipopolysaccharide 1,2-glucosyltransferase
type: Protein
entity reference: Lipopolysaccharide 1,2-glucosyltransferase

Reference/KEGG Compound C00075
type: UnificationXref
id: C00075
db: KEGG Compound

Protein/7360/Stoichiometry/4.0
type: Stoichiometry
physical entity: Protein gutQ
stoichiometric coefficient: 4.0

Phosphate
type: SmallMolecule
entity reference: Phosphate

Reference/BioCyc CMP
type: UnificationXref
id: CMP
db: BioCyc

Bifunctional protein glmU
type: Protein
entity reference: Bifunctional protein glmU

Compound/PW C040736/Stoichiometry/1.0
type: Stoichiometry
physical entity: a-Kdo-(2->4)-a-Kdo-(2->6)-lipid IVA
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 57957
type: UnificationXref
id: CHEBI:57957
db: ChEBI

Reference/KEGG Compound C00080
type: UnificationXref
id: C00080
db: KEGG Compound

PE(16:0/16:0)
type: SmallMolecule
entity reference: PE(16:0/16:0)

Reference/KEGG Compound C00085
type: UnificationXref
id: C00085
db: KEGG Compound

Reference/PubChem-compound 9965052
type: UnificationXref
id: 9965052
db: PubChem-compound

Compound/PW C040736 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: a-Kdo-(2->4)-a-Kdo-(2->6)-lipid IVA
stoichiometric coefficient: 1.0

Lipid A biosynthesis lauroyl acyltransferase
type: Protein
entity reference: Lipid A biosynthesis lauroyl acyltransferase

Reference/HMDB HMDB0000290
type: UnificationXref
id: HMDB0000290
db: HMDB

Reference/PubChem-compound 8490
type: UnificationXref
id: 8490
db: PubChem-compound

Reference/PathWhiz PW001905
type: UnificationXref
id: PW001905
db: PathWhiz

Reference/HMDB HMDB0002111
type: UnificationXref
id: HMDB0002111
db: HMDB

Compound/Generic86/Stoichiometry/1.0
type: Stoichiometry
physical entity: a holo-[acyl-carrier protein]
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000095
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(O)=O)C(O)=O

N-Acetyl-glucosamine 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: N-Acetyl-glucosamine 1-phosphate

Reference/ChemSpider 5808
type: UnificationXref
id: 5808
db: ChemSpider

Compound/PW C040740 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: (KDO)2-lipid A
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 44897
type: UnificationXref
id: CHEBI:44897
db: ChEBI

Reference/CAS 14265-44-2
type: UnificationXref
id: 14265-44-2
db: CAS

Reference/PubChem-compound 6176
type: UnificationXref
id: 6176
db: PubChem-compound

D-Ribulose 5-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 4151-19-3
xref: Reference/BioCyc RIBULOSE-5P
xref: Reference/KEGG Compound C00199
xref: Reference/PubChem-compound 439184
xref: Reference/HMDB HMDB0000618
xref: Reference/ChEBI CHEBI 17363
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C000479

Reference/CAS 58-64-0
type: UnificationXref
id: 58-64-0
db: CAS

Compound/PW C040982/Stoichiometry/1.0
type: Stoichiometry
physical entity: lipid IVA
stoichiometric coefficient: 1.0

Lipopolysaccharide export system protein lptC
type: Protein
entity reference: Lipopolysaccharide export system protein lptC

dodecanoyl-[acp]
type: Protein
entity reference: dodecanoyl-[acp]

Compound/PW C040034 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

Reference/UniProt P37661
type: UnificationXref
id: P37661
db: UniProt

Reference/PubChem-compound 644102
type: UnificationXref
id: 644102
db: PubChem-compound

Reference/PubChem-compound 444493
type: UnificationXref
id: 444493
db: PubChem-compound

Reference/ChemSpider 5941
type: UnificationXref
id: 5941
db: ChemSpider

Uridine diphosphate-N-acetylglucosamine
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine diphosphate-N-acetylglucosamine

D-Ribulose 5-phosphate
type: SmallMolecule
entity reference: D-Ribulose 5-phosphate
name: SubPathwayOutput

Reference/PubChem-compound 445468
type: UnificationXref
id: 445468
db: PubChem-compound

Reference/PubChem-compound 188324
type: UnificationXref
id: 188324
db: PubChem-compound

ChemicalStructure/PW C000196
type: ChemicalStructure
structure format: SMILES

Compound/PW C040996/Stoichiometry/1.0
type: Stoichiometry
physical entity: galactosyl-(glucosyl)3-(heptosyl)3-Kdo2-lipid A-bisphosphate
stoichiometric coefficient: 1.0

Reference/BioCyc ACETYL-COA
type: UnificationXref
id: ACETYL-COA
db: BioCyc

Reference/ChEBI CHEBI 18050
type: UnificationXref
id: CHEBI:18050
db: ChEBI

Water
type: SmallMoleculeReference
xref: Reference/PubChem-compound 962
xref: Reference/ChEBI CHEBI 15377
xref: Reference/KEGG Compound C00001
xref: Reference/ChemSpider 937
xref: Reference/HMDB HMDB0002111
xref: Reference/CAS 7732-18-5
chemical formula: H2O
molecular weight: 18.010565
structure: ChemicalStructure/PW C001420

Compound/PW C040989/Stoichiometry/1.0
type: Stoichiometry
physical entity: glucosyl-(heptosyl)2-Kdo2-lipid A
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000079
type: ChemicalStructure
structure format: SMILES

TransportCatalysis417
type: Catalysis
controller: lipopolysaccharide transport system
controlled: Transport485
control type: ACTIVATION

UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase
type: Complex
component stoichiometry: Protein/6400/Stoichiometry/3.0
component: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Compound/PW C040976/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-α-D-glucosamine
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000194
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000193
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C000192
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P37692
type: UnificationXref
id: P37692
db: UniProt

phosphoethanolamine-Kdo2-lipid A
type: SmallMolecule
entity reference: phosphoethanolamine-Kdo2-lipid A

Tetraacyldisaccharide 4'-kinase
type: Protein
cellular location: Cytosol
entity reference: Tetraacyldisaccharide 4'-kinase

ChemicalStructure/PW C040976
type: ChemicalStructure
structure format: SMILES

Protein/Generic176/Stoichiometry/1.0
type: Stoichiometry
physical entity: dodecanoyl-[acp]
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0059597
type: UnificationXref
id: HMDB0059597
db: HMDB

Reference/BioCyc UMP
type: UnificationXref
id: UMP
db: BioCyc

2,3-bis[(3R)-3-hydroxymyristoyl]-α-D-glucosaminyl 1-phosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: 2,3-bis[(3R)-3-hydroxymyristoyl]-α-D-glucosaminyl 1-phosphate

ChemicalStructure/PW C040979
type: ChemicalStructure
structure format: SMILES
structure data: CCCCCCCCCCCC(O)CC(=O)NC1C(OP([O-])([O-])=O)OC(CO)C(O)C1OC(=O)CC(O)CCCCCCCCCCC

ChemicalStructure/PW C040978
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040736
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040977
type: ChemicalStructure
structure format: SMILES

ChemicalStructure/PW C040739
type: ChemicalStructure
structure format: SMILES

D-arabinose 5-phosphate isomerase
type: Complex
component stoichiometry: Protein/7360/Stoichiometry/4.0
component: Protein gutQ

ChemicalStructure/PW C001055
type: ChemicalStructure
structure format: SMILES

Reference/UniProt P0A9V1
type: UnificationXref
id: P0A9V1
db: UniProt

3-deoxy-D-manno-octulosonate 8-phosphate synthase
type: Complex
component stoichiometry: Protein/6022/Stoichiometry/4.0
component: 2-dehydro-3-deoxyphosphooctonate aldolase

D-arabinose 5-phosphate isomerase 2
type: Complex
component stoichiometry: Protein/6627/Stoichiometry/4.0
component: Arabinose 5-phosphate isomerase

Reference/HMDB HMDB0008923
type: UnificationXref
id: HMDB0008923
db: HMDB

Reference/ChemSpider 980
type: UnificationXref
id: 980
db: ChemSpider

lipid A disaccharide synthase
type: Complex
component stoichiometry: Protein/6302/Stoichiometry/8.0
component: Lipid-A-disaccharide synthase

Reference/UniProt P0A715
type: UnificationXref
id: P0A715
db: UniProt

Reference/HMDB HMDB0000082
type: UnificationXref
id: HMDB0000082
db: HMDB

Adenosine diphosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Adenosine diphosphate

Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]
type: Protein
entity reference: Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]

3-deoxy-D-manno-octulosonate 8-phosphate phosphatase
type: Complex
component stoichiometry: Protein/6191/Stoichiometry/4.0
component: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase

Compound/PW C001104 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

UDP-α-D-galactose
type: SmallMolecule
entity reference: UDP-α-D-galactose

galactosyl-glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate
type: SmallMolecule
entity reference: galactosyl-glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate

galactosyl-(glucosyl)2-(heptosyl)3-Kdo2-lipid A-bisphosphate
type: SmallMolecule
entity reference: galactosyl-(glucosyl)2-(heptosyl)3-Kdo2-lipid A-bisphosphate

Reference/ChemSpider 30572
type: UnificationXref
id: 30572
db: ChemSpider

galactosyl-(glucosyl)3-(heptosyl)3-Kdo2-lipid A-bisphosphate
type: SmallMolecule
entity reference: galactosyl-(glucosyl)3-(heptosyl)3-Kdo2-lipid A-bisphosphate

Reference/BioCyc CPD-535
type: UnificationXref
id: CPD-535
db: BioCyc

Acetic acid
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 15366
xref: Reference/BioCyc ACET
xref: Reference/CAS 64-19-7
xref: Reference/KEGG Compound C00033
xref: Reference/ChemSpider 171
xref: Reference/HMDB HMDB0000042
xref: Reference/PubChem-compound 176
chemical formula: C2H4O2
molecular weight: 60.02113
structure: ChemicalStructure/PW C000029

Reference/UniProt P04951
type: UnificationXref
id: P04951
db: UniProt

glucosyl-(heptosyl)2-Kdo2-lipid A-phosphate
type: SmallMolecule
entity reference: glucosyl-(heptosyl)2-Kdo2-lipid A-phosphate

glucosyl-(heptosyl)3-Kdo2-lipid A-phosphate
type: SmallMolecule
entity reference: glucosyl-(heptosyl)3-Kdo2-lipid A-phosphate

glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate
type: SmallMolecule
entity reference: glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate

Compound/PW C040987/Stoichiometry/1.0
type: Stoichiometry
physical entity: heptosyl-Kdo2-lipid A
stoichiometric coefficient: 1.0

lipid A-core
type: SmallMolecule
entity reference: lipid A-core

Compound/PW C040978 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine
stoichiometric coefficient: 1.0

Compound/PW C040986/Stoichiometry/1.0
type: Stoichiometry
physical entity: α-Kdo-(2→6)-lipid IVA
stoichiometric coefficient: 1.0

Cytidine triphosphate
type: SmallMolecule
entity reference: Cytidine triphosphate

Reference/BioCyc L-1-PHOSPHATIDYL-ETHANOLAMINE
type: UnificationXref
id: L-1-PHOSPHATIDYL-ETHANOLAMINE
db: BioCyc

Reference/CAS 64-19-7
type: UnificationXref
id: 64-19-7
db: CAS

Reference/UniProt P24205
type: UnificationXref
id: P24205
db: UniProt

ChemicalStructure/PW C001420
type: ChemicalStructure
structure format: SMILES
structure data: O

Lipopolysaccharide export system protein lptA
type: Protein
entity reference: Lipopolysaccharide export system protein lptA

Compound/PW C000517 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Fructose
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 9803
type: UnificationXref
id: CHEBI:9803
db: ChEBI

Pyrophosphate
type: SmallMolecule
entity reference: Pyrophosphate

lipid IVA
type: SmallMolecule
entity reference: lipid IVA

(KDO)2-lipid A
type: SmallMolecule
entity reference: (KDO)2-lipid A

3-deoxy-D-manno-octulosonate 8-phosphate
type: SmallMolecule
entity reference: 3-deoxy-D-manno-octulosonate 8-phosphate

Compound/PW C040988/Stoichiometry/1.0
type: Stoichiometry
physical entity: (heptosyl)2-Kdo2-lipid A
stoichiometric coefficient: 1.0

3-deoxy-D-manno-octulosonate
type: SmallMolecule
entity reference: 3-deoxy-D-manno-octulosonate

CMP-3-deoxy-α-D-manno-octulosonate
type: SmallMolecule
entity reference: CMP-3-deoxy-α-D-manno-octulosonate

Reference/PubChem-compound 439709
type: UnificationXref
id: 439709
db: PubChem-compound

UDP
type: SmallMolecule
entity reference: UDP

a-Kdo-(2->4)-a-Kdo-(2->6)-lipid IVA
type: SmallMolecule
cellular location: Cytosol
entity reference: a-Kdo-(2->4)-a-Kdo-(2->6)-lipid IVA

lipid A disaccharide
type: SmallMolecule
entity reference: lipid A disaccharide

UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-α-D-glucosamine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 61494
chemical formula: C31H53N3O19P2
molecular weight: 833.27484
structure: ChemicalStructure/PW C040976

Reference/ChEBI CHEBI 58466
type: UnificationXref
id: CHEBI:58466
db: ChEBI

Reference/HMDB HMDB0000538
type: UnificationXref
id: HMDB0000538
db: HMDB

UDP-3-O-(3-hydroxymyristoyl)-α-D-glucosamine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 71573
chemical formula: C29H50N3O18P2
molecular weight: 790.2565
structure: ChemicalStructure/PW C040977

Reference/ChEBI CHEBI 58223
type: UnificationXref
id: CHEBI:58223
db: ChEBI

UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 9803
chemical formula: C43H77N3O20P2
molecular weight: 1017.4576
structure: ChemicalStructure/PW C040978

a-Kdo-(2->4)-a-Kdo-(2->6)-lipid IVA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C06025
xref: Reference/ChEBI CHEBI 60365
chemical formula: C84H148N2O37P2
molecular weight: 1838.9269
structure: ChemicalStructure/PW C040736

2,3-bis[(3R)-3-hydroxymyristoyl]-α-D-glucosaminyl 1-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 57957
chemical formula: C34H64NO12P
molecular weight: 709.4177
structure: ChemicalStructure/PW C040979

Reference/PubChem-compound 1005
type: UnificationXref
id: 1005
db: PubChem-compound

α-Kdo-(2→6)-lipid IVA
type: SmallMolecule
entity reference: α-Kdo-(2→6)-lipid IVA

Reference/PubChem-compound 5961
type: UnificationXref
id: 5961
db: PubChem-compound

heptosyl-Kdo2-lipid A
type: SmallMolecule
entity reference: heptosyl-Kdo2-lipid A

(KDO)2-(lauroyl)-lipid IVA
type: SmallMoleculeReference
xref: Reference/KEGG Compound C06251
xref: Reference/ChEBI CHEBI 61524
xref: Reference/PubChem-compound 8490
chemical formula: C96H176N2O38P2
molecular weight: 2027.1376
structure: ChemicalStructure/PW C040739

Compound/PW C001034 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

(heptosyl)2-Kdo2-lipid A
type: SmallMolecule
entity reference: (heptosyl)2-Kdo2-lipid A

Reference/UniProt P45395
type: UnificationXref
id: P45395
db: UniProt

glucosyl-(heptosyl)2-Kdo2-lipid A
type: SmallMolecule
entity reference: glucosyl-(heptosyl)2-Kdo2-lipid A

D-fructose-6-phosphate aminotransferase
type: Complex
component stoichiometry: Protein/6361/Stoichiometry/2.0
component: Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]

Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
type: Protein
entity reference: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

2-dehydro-3-deoxyphosphooctonate aldolase
type: Protein
entity reference: 2-dehydro-3-deoxyphosphooctonate aldolase

Compound/PW C000414/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 643-13-0
type: UnificationXref
id: 643-13-0
db: CAS

Reference/CAS 528-04-1
type: UnificationXref
id: 528-04-1
db: CAS

Compound/PW C000180/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphoenolpyruvic acid
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 61506
type: UnificationXref
id: CHEBI:61506
db: ChEBI

Reference/UniProt P0ACC7
type: UnificationXref
id: P0ACC7
db: UniProt

Reference/PubChem-compound 6816
type: UnificationXref
id: 6816
db: PubChem-compound

Reference/ChEBI CHEBI 61507
type: UnificationXref
id: CHEBI:61507
db: ChEBI

UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
type: Protein
entity reference: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Protein/6191/Stoichiometry/4.0
type: Stoichiometry
physical entity: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 61502
type: UnificationXref
id: CHEBI:61502
db: ChEBI

Reference/BioCyc ADP
type: UnificationXref
id: ADP
db: BioCyc

Reference/HMDB HMDB0000660
type: UnificationXref
id: HMDB0000660
db: HMDB

UDP
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58223
chemical formula: C9H14N2O12P2
molecular weight: 404.0022
structure: ChemicalStructure/PW C040980

lipid A disaccharide
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58466
chemical formula: C68H127N2O20P
molecular weight: 1322.872
structure: ChemicalStructure/PW C040981

Compound/PW C044492 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: phosphoethanolamine-Kdo2-lipid A
stoichiometric coefficient: 1.0

lipid IVA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58603
chemical formula: C68H126N2O23P2
molecular weight: 1400.8226
structure: ChemicalStructure/PW C040982

(KDO)2-lipid A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58540
xref: Reference/KEGG Compound C06026
chemical formula: C110H196N2O39P2
molecular weight: 2231.2922
structure: ChemicalStructure/PW C040740

3-deoxy-D-manno-octulosonate 8-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 58368
chemical formula: C8H12O11P
molecular weight: 315.01337
structure: ChemicalStructure/PW C040983

3-deoxy-D-manno-octulosonate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 16064
chemical formula: C8H13O8
molecular weight: 237.06158
structure: ChemicalStructure/PW C040984

Reference/UniProt P60752
type: UnificationXref
id: P60752
db: UniProt

CMP-3-deoxy-α-D-manno-octulosonate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 18014
chemical formula: C17H26N3O15P
molecular weight: 543.11017
structure: ChemicalStructure/PW C040985

α-Kdo-(2→6)-lipid IVA
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 60364
chemical formula: C76H137N2O30P2
molecular weight: 1619.8759
structure: ChemicalStructure/PW C040986

heptosyl-Kdo2-lipid A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 61502
chemical formula: C117H208N2O45P2
molecular weight: 2423.3557
structure: ChemicalStructure/PW C040987

Compound/PW C000940/Stoichiometry/1.0
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

(heptosyl)2-Kdo2-lipid A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 61507
chemical formula: C126H225N2O49P2
molecular weight: 2612.4678
structure: ChemicalStructure/PW C040988

glucosyl-(heptosyl)2-Kdo2-lipid A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 61997
chemical formula: C130H230N2O56P2
molecular weight: 2777.472
structure: ChemicalStructure/PW C040989

Reference/PubChem-compound 1038
type: UnificationXref
id: 1038
db: PubChem-compound

Reference/KEGG Compound C04256
type: UnificationXref
id: C04256
db: KEGG Compound

Uridine 5'-monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine 5'-monophosphate

α-Kdo-(2→6)-lipid IVA
type: SmallMolecule
cellular location: Cytosol
entity reference: α-Kdo-(2→6)-lipid IVA

Reference/GENE ONTOLOGY GO 0005829
type: UnificationXref
id: GO:0005829
db: GENE ONTOLOGY

PE(16:0/16:0)
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0008923
xref: Reference/BioCyc L-1-PHOSPHATIDYL-ETHANOLAMINE
xref: Reference/ChemSpider 393103
xref: Reference/KEGG Compound C00350
xref: Reference/CAS 923-61-5
xref: Reference/PubChem-compound 445468
xref: Reference/ChEBI CHEBI 73005
chemical formula: C37H74NO8P
molecular weight: 691.5152
structure: ChemicalStructure/PW C004971

Compound/PW C040985 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: CMP-3-deoxy-α-D-manno-octulosonate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 61999
type: UnificationXref
id: CHEBI:61999
db: ChEBI

fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
type: Complex
component stoichiometry: Protein/6211/Stoichiometry/3.0
component: Bifunctional protein glmU

Reference/ChEBI CHEBI 61997
type: UnificationXref
id: CHEBI:61997
db: ChEBI

Reference/ChEBI CHEBI 61998
type: UnificationXref
id: CHEBI:61998
db: ChEBI

Protein gutQ
type: Protein
entity reference: Protein gutQ

Compound/PW C040983/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-deoxy-D-manno-octulosonate 8-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 393240
type: UnificationXref
id: 393240
db: ChemSpider

glucosyl-(heptosyl)2-Kdo2-lipid A-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 61998
chemical formula: C130H229N2O59P3
molecular weight: 2855.4238
structure: ChemicalStructure/PW C040990

ADP-L-glycero-β-D-manno-heptose
type: SmallMolecule
entity reference: ADP-L-glycero-β-D-manno-heptose

glucosyl-(heptosyl)3-Kdo2-lipid A-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 61999
chemical formula: C137H241N2O65P3
molecular weight: 3047.487
structure: ChemicalStructure/PW C040991

glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 62000
chemical formula: C137H240N2O68P4
molecular weight: 3125.439
structure: ChemicalStructure/PW C040992

Fructose 6-phosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Fructose 6-phosphate

Compound/PW C040763/Stoichiometry/1.0
type: Stoichiometry
physical entity: ADP-L-glycero-β-D-manno-heptose
stoichiometric coefficient: 1.0

UDP-α-D-galactose
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0062573
xref: Reference/ChEBI CHEBI 58439
chemical formula: C15H24N2O17P2
molecular weight: 566.055
structure: ChemicalStructure/PW C040993

galactosyl-glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 62001
chemical formula: C143H250N2O73P4
molecular weight: 3287.4917
structure: ChemicalStructure/PW C040994

Compound/PW C040986 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: α-Kdo-(2→6)-lipid IVA
stoichiometric coefficient: 1.0

galactosyl-(glucosyl)2-(heptosyl)3-Kdo2-lipid A-bisphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 62002
chemical formula: C149H260N2O78P4
molecular weight: 3449.5444
structure: ChemicalStructure/PW C040995

galactosyl-(glucosyl)3-(heptosyl)3-Kdo2-lipid A-bisphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 62003
chemical formula: C155H270N2O83P4
molecular weight: 3611.5974
structure: ChemicalStructure/PW C040996

Reference/ChEBI CHEBI 15713
type: UnificationXref
id: CHEBI:15713
db: ChEBI

Compound/PW C040985/Stoichiometry/1.0
type: Stoichiometry
physical entity: CMP-3-deoxy-α-D-manno-octulosonate
stoichiometric coefficient: 1.0

lipid A-core
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 62004
chemical formula: C162H296N2O89P4
molecular weight: 3817.765
structure: ChemicalStructure/PW C040997

Pyrophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Pyrophosphate

Phosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00009
xref: Reference/PubChem-compound 1061
xref: Reference/CAS 14265-44-2
xref: Reference/HMDB HMDB0001429
xref: Reference/BioCyc CPD-8587
xref: Reference/ChEBI CHEBI 18367
xref: Reference/ChemSpider 1032
chemical formula: H3O4P
molecular weight: 97.9769
structure: ChemicalStructure/PW C001104

Acetic acid
type: SmallMolecule
entity reference: Acetic acid

Protein/6022/Stoichiometry/4.0
type: Stoichiometry
physical entity: 2-dehydro-3-deoxyphosphooctonate aldolase
stoichiometric coefficient: 4.0

Reference/ChEBI CHEBI 58368
type: UnificationXref
id: CHEBI:58368
db: ChEBI

Reference/GENE ONTOLOGY GO 0070258
type: UnificationXref
id: GO:0070258
db: GENE ONTOLOGY

Cytidine monophosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Cytidine monophosphate

Lipopolysaccharide 1,3-galactosyltransferase
type: Protein
entity reference: Lipopolysaccharide 1,3-galactosyltransferase

Reference/ChEBI CHEBI 15946
type: UnificationXref
id: CHEBI:15946
db: ChEBI

Reference/ChEBI CHEBI 61524
type: UnificationXref
id: CHEBI:61524
db: ChEBI

Compound/PW C040981/Stoichiometry/1.0
type: Stoichiometry
physical entity: lipid A disaccharide
stoichiometric coefficient: 1.0

mannose PTS permease
type: Complex
component stoichiometry: Protein/6697 Inner Membrane/Stoichiometry/2.0
component stoichiometry: Protein/7147 Inner Membrane/Stoichiometry/2.0
cellular location: Inner Membrane
component: Mannose permease IIC component
component: Mannose permease IID component
component: PTS system mannose-specific EIIAB component

Reference/PathWhiz PW000785
type: UnificationXref
id: PW000785
db: PathWhiz

D-Fructose
type: SmallMolecule
cellular location: Inner Membrane
entity reference: D-Fructose

Uridine diphosphate glucose
type: SmallMoleculeReference
xref: Reference/BioCyc UDP-GLUCOSE
xref: Reference/KEGG Compound C00029
xref: Reference/PubChem-compound 53477679
xref: Reference/CAS 133-89-1
xref: Reference/HMDB HMDB0000286
chemical formula: C15H24N2O17P2
molecular weight: 566.055
structure: ChemicalStructure/PW C000193

Reference/BioCyc UDP-GLUCOSE
type: UnificationXref
id: UDP-GLUCOSE
db: BioCyc

Reference/UniProt P69797
type: UnificationXref
id: P69797
db: UniProt

Uridine triphosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 6133
xref: Reference/CAS 63-39-8
xref: Reference/ChemSpider 5903
xref: Reference/ChEBI CHEBI 15713
xref: Reference/KEGG Compound C00075
xref: Reference/HMDB HMDB0000285
xref: Reference/BioCyc UTP
chemical formula: C9H15N2O15P3
molecular weight: 483.96854
structure: ChemicalStructure/PW C000192

L-Glutamic acid
type: SmallMolecule
entity reference: L-Glutamic acid

Reference/HMDB HMDB0001423
type: UnificationXref
id: HMDB0001423
db: HMDB

Mannose permease IID component
type: Protein
cellular location: Inner Membrane
entity reference: Mannose permease IID component

ChemicalStructure/PW C001104
type: ChemicalStructure
structure format: SMILES
structure data: OP(O)(O)=O

Compound/PW C000057/Stoichiometry/1.0
type: Stoichiometry
physical entity: Cytidine triphosphate
stoichiometric coefficient: 1.0

ChemicalStructure/PW C004971
type: ChemicalStructure
structure format: SMILES

Reference/ChemSpider 393103
type: UnificationXref
id: 393103
db: ChemSpider

Fructose 6-phosphate
type: SmallMoleculeReference
xref: Reference/CAS 643-13-0
xref: Reference/HMDB HMDB0000124
xref: Reference/KEGG Compound C00085
xref: Reference/ChEBI CHEBI 15946
xref: Reference/BioCyc FRUCTOSE-6P
xref: Reference/PubChem-compound 69507
xref: Reference/ChemSpider 62713
chemical formula: C6H13O9P
molecular weight: 260.02972
structure: ChemicalStructure/PW C000079

Uridine diphosphate-N-acetylglucosamine
type: SmallMoleculeReference
xref: Reference/CAS 528-04-1
xref: Reference/PubChem-compound 445675
xref: Reference/HMDB HMDB0000290
xref: Reference/BioCyc UDP-N-ACETYL-D-GLUCOSAMINE
xref: Reference/KEGG Compound C00043
xref: Reference/ChEBI CHEBI 16264
xref: Reference/ChemSpider 393240
chemical formula: C17H27N3O17P2
molecular weight: 607.08154
structure: ChemicalStructure/PW C000196

Hydrogen Ion
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Hydrogen Ion

Compound/PW C040980/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP
stoichiometric coefficient: 1.0

Uridine 5'-monophosphate
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0000288
xref: Reference/CAS 58-97-9
xref: Reference/KEGG Compound C00105
xref: Reference/PubChem-compound 6030
xref: Reference/BioCyc UMP
xref: Reference/ChEBI CHEBI 16695
xref: Reference/ChemSpider 5808
chemical formula: C9H13N2O9P
molecular weight: 324.03586
structure: ChemicalStructure/PW C000194

phosphoethanolamine-Kdo2-lipid A
type: SmallMolecule
cellular location: Extracellular Space
entity reference: phosphoethanolamine-Kdo2-lipid A

a holo-[acyl-carrier protein]
type: SmallMolecule
entity reference: a holo-[acyl-carrier protein]

Compound/PW C000194 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine 5'-monophosphate
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0007098
type: UnificationXref
id: HMDB0007098
db: HMDB

lipid A-core
type: SmallMolecule
cellular location: Inner Membrane
entity reference: lipid A-core

Reference/HMDB HMDB0001429
type: UnificationXref
id: HMDB0001429
db: HMDB

Reference/ChEBI CHEBI 58540
type: UnificationXref
id: CHEBI:58540
db: ChEBI

Inner Membrane
type: CellularLocationVocabulary
xref: Reference/GENE ONTOLOGY GO 0070258

UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine
type: SmallMolecule
cellular location: Cytosol
entity reference: UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine

N-Acetyl-glucosamine 1-phosphate
type: SmallMolecule
entity reference: N-Acetyl-glucosamine 1-phosphate

Lipopolysaccharide export system permease protein lptG
type: Protein
entity reference: Lipopolysaccharide export system permease protein lptG

ReactionCatalysis2987
type: Catalysis
controller: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
controlled: 3.5.1.-
control type: ACTIVATION

ReactionCatalysis2986
type: Catalysis
controller: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
controlled: 2.3.1.129
control type: ACTIVATION

N-Acetyl-glucosamine 1-phosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 7125
xref: Reference/ChemSpider 389248
xref: Reference/HMDB HMDB0001367
xref: Reference/PubChem-compound 440272
xref: Reference/BioCyc N-ACETYL-D-GLUCOSAMINE-1-P
xref: Reference/CAS 6866-69-9
xref: Reference/KEGG Compound C04256
chemical formula: C8H16NO9P
molecular weight: 301.05627
structure: ChemicalStructure/PW C001055

ReactionCatalysis2989
type: Catalysis
controller: UDP-2,3-diacylglucosamine hydrolase
controlled: 3.6.1.54
control type: ACTIVATION

ReactionCatalysis2988
type: Catalysis
controller: UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase
controlled: 2.3.1.191
control type: ACTIVATION

Reference/BioCyc GLN
type: UnificationXref
id: GLN
db: BioCyc

Reference/BioCyc GLT
type: UnificationXref
id: GLT
db: BioCyc

Reference/PubChem-compound 69507
type: UnificationXref
id: 69507
db: PubChem-compound

Mannose permease IIC component
type: Protein
cellular location: Inner Membrane
entity reference: Mannose permease IIC component

Compound/PW C040034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Hydrogen Ion
stoichiometric coefficient: 1.0

fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
type: Complex
component stoichiometry: Protein/6211 Cytosol/Stoichiometry/3.0
cellular location: Cytosol
component: Bifunctional protein glmU

2,3-bis[(3R)-3-hydroxymyristoyl]-α-D-glucosaminyl 1-phosphate
type: SmallMolecule
entity reference: 2,3-bis[(3R)-3-hydroxymyristoyl]-α-D-glucosaminyl 1-phosphate

(KDO)2-(lauroyl)-lipid IVA
type: SmallMolecule
entity reference: (KDO)2-(lauroyl)-lipid IVA

Compound/PW C040984/Stoichiometry/1.0
type: Stoichiometry
physical entity: 3-deoxy-D-manno-octulosonate
stoichiometric coefficient: 1.0

UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-α-D-glucosamine
type: SmallMolecule
entity reference: UDP-3-O-[(3R)-3-hydroxymyristoyl]-N-acetyl-α-D-glucosamine

UDP-3-O-(3-hydroxymyristoyl)-α-D-glucosamine
type: SmallMolecule
entity reference: UDP-3-O-(3-hydroxymyristoyl)-α-D-glucosamine

UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine
type: SmallMolecule
entity reference: UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine

a holo-[acyl-carrier protein]
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00229

a-Kdo-(2->4)-a-Kdo-(2->6)-lipid IVA
type: SmallMolecule
entity reference: a-Kdo-(2->4)-a-Kdo-(2->6)-lipid IVA

Reference/UniProt P0ADC1
type: UnificationXref
id: P0ADC1
db: UniProt

ReactionCatalysis2996
type: Catalysis
controller: 3-deoxy-manno-octulosonate cytidylyltransferase
controlled: 2.7.7.38
control type: ACTIVATION

Uridine diphosphate-N-acetylglucosamine
type: SmallMolecule
entity reference: Uridine diphosphate-N-acetylglucosamine

ReactionCatalysis2995
type: Catalysis
controller: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase
controlled: 3.1.3.45
control type: ACTIVATION

Pyrophosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 644102
xref: Reference/BioCyc PPI
xref: Reference/ChemSpider 559142
xref: Reference/ChEBI CHEBI 18361
xref: Reference/HMDB HMDB0000250
xref: Reference/CAS 14000-31-8
xref: Reference/KEGG Compound C00013
chemical formula: H4O7P2
molecular weight: 177.94322
structure: ChemicalStructure/PW C000170

ReactionCatalysis2998
type: Catalysis
controller: 3-deoxy-D-manno-octulosonic-acid transferase
controlled: Reaction3035
control type: ACTIVATION

ReactionCatalysis2997
type: Catalysis
controller: 3-deoxy-D-manno-octulosonic-acid transferase
controlled: 2.4.99.12
control type: ACTIVATION

Uridine diphosphate glucose
type: SmallMolecule
entity reference: Uridine diphosphate glucose

Fructose 6-phosphate
type: SmallMolecule
entity reference: Fructose 6-phosphate
name: SubPathwayOutput

ReactionCatalysis2999
type: Catalysis
controller: Lipid A biosynthesis lauroyl acyltransferase
controlled: 2.3.1.-
control type: ACTIVATION

Reference/PubChem-compound 5957
type: UnificationXref
id: 5957
db: PubChem-compound

Reference/HMDB HMDB0001206
type: UnificationXref
id: HMDB0001206
db: HMDB

(KDO)2-lipid A
type: SmallMolecule
cellular location: Cytosol
entity reference: (KDO)2-lipid A

Cytidine triphosphate
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 17677
xref: Reference/CAS 65-47-4
xref: Reference/PubChem-compound 6176
xref: Reference/KEGG Compound C00063
xref: Reference/ChemSpider 5941
xref: Reference/HMDB HMDB0000082
xref: Reference/BioCyc CTP
chemical formula: C9H16N3O14P3
molecular weight: 482.9845
structure: ChemicalStructure/PW C000057

Compound/PW C001055/Stoichiometry/1.0
type: Stoichiometry
physical entity: N-Acetyl-glucosamine 1-phosphate
stoichiometric coefficient: 1.0

ReactionCatalysis2990
type: Catalysis
controller: lipid A disaccharide synthase
controlled: 2.4.1.182
control type: ACTIVATION

3-deoxy-D-manno-octulosonate 8-phosphate phosphatase
type: Protein
entity reference: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase

ReactionCatalysis2992
type: Catalysis
controller: D-arabinose 5-phosphate isomerase
controlled: 5.3.1.13
control type: ACTIVATION

ChemicalStructure/PW C044492
type: ChemicalStructure
structure format: SMILES

ReactionCatalysis2991
type: Catalysis
controller: Tetraacyldisaccharide 4'-kinase
controlled: 2.7.1.130
control type: ACTIVATION

ReactionCatalysis2994
type: Catalysis
controller: 3-deoxy-D-manno-octulosonate 8-phosphate synthase
controlled: 2.5.1.55
control type: ACTIVATION

Protein/6302/Stoichiometry/8.0
type: Stoichiometry
physical entity: Lipid-A-disaccharide synthase
stoichiometric coefficient: 8.0

ReactionCatalysis2993
type: Catalysis
controller: D-arabinose 5-phosphate isomerase 2
controlled: 5.3.1.13
control type: ACTIVATION

Lipopolysaccharide core biosynthesis protein rfaG
type: ProteinReference
xref: Reference/UniProt P25740

Lipopolysaccharide core heptosyltransferase rfaQ
type: ProteinReference
xref: Reference/UniProt P25742

Reference/ChEBI CHEBI 15873
type: UnificationXref
id: CHEBI:15873
db: ChEBI

Phosphoethanolamine transferase eptB
type: ProteinReference
xref: Reference/UniProt P37661

Reference/UniProt P25741
type: UnificationXref
id: P25741
db: UniProt

Reference/UniProt P25740
type: UnificationXref
id: P25740
db: UniProt

ChemicalStructure/PW C000479
type: ChemicalStructure
structure format: SMILES
structure data: OCC(=O)[C@H](O)[C@H](O)COP(O)(O)=O

Cytidine monophosphate
type: SmallMolecule
entity reference: Cytidine monophosphate

Adenosine diphosphate
type: SmallMolecule
entity reference: Adenosine diphosphate

Phosphoenolpyruvic acid
type: SmallMoleculeReference
xref: Reference/CAS 138-08-9
xref: Reference/ChEBI CHEBI 44897
xref: Reference/KEGG Compound C00074
xref: Reference/BioCyc PHOSPHO-ENOL-PYRUVATE
xref: Reference/ChemSpider 980
xref: Reference/PubChem-compound 1005
xref: Reference/HMDB HMDB0000263
chemical formula: C3H5O6P
molecular weight: 167.98238
structure: ChemicalStructure/PW C000180

Reference/ChEBI CHEBI 58439
type: UnificationXref
id: CHEBI:58439
db: ChEBI

Reference/HMDB HMDB0000124
type: UnificationXref
id: HMDB0000124
db: HMDB

Adenosine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine triphosphate

Adenosine diphosphate
type: SmallMoleculeReference
xref: Reference/KEGG Compound C00008
xref: Reference/PubChem-compound 6022
xref: Reference/ChemSpider 5800
xref: Reference/CAS 58-64-0
xref: Reference/BioCyc ADP
xref: Reference/ChEBI CHEBI 16761
xref: Reference/HMDB HMDB0001341
chemical formula: C10H15N5O10P2
molecular weight: 427.02942
structure: ChemicalStructure/PW C001034

Reference/KEGG Compound C06251
type: UnificationXref
id: C06251
db: KEGG Compound

Reference/UniProt P0ADC6
type: UnificationXref
id: P0ADC6
db: UniProt

Reference/GENE ONTOLOGY GO 0005615
type: UnificationXref
id: GO:0005615
db: GENE ONTOLOGY

Reference/CAS 4151-19-3
type: UnificationXref
id: 4151-19-3
db: CAS

Reference/UniProt P25742
type: UnificationXref
id: P25742
db: UniProt

Lipopolysaccharide export system ATP-binding protein lptB
type: Protein
entity reference: Lipopolysaccharide export system ATP-binding protein lptB

Phosphoenolpyruvic acid
type: SmallMolecule
entity reference: Phosphoenolpyruvic acid

Cytidine monophosphate
type: SmallMoleculeReference
xref: Reference/BioCyc CMP
xref: Reference/ChemSpider 5901
xref: Reference/PubChem-compound 6131
xref: Reference/ChEBI CHEBI 17361
xref: Reference/KEGG Compound C00055
xref: Reference/HMDB HMDB0000095
xref: Reference/CAS 63-37-6
chemical formula: C9H14N3O8P
molecular weight: 323.05185
structure: ChemicalStructure/PW C000064

Lipopolysaccharide export system permease protein lptF
type: Protein
entity reference: Lipopolysaccharide export system permease protein lptF

(3R)-3-hydroxymyristoyl-[acp]
type: ProteinReference

Protein/Generic191/Stoichiometry/1.0
type: Stoichiometry
physical entity: (3R)-3-hydroxymyristoyl-[acp]
stoichiometric coefficient: 1.0

Lipopolysaccharide heptosyltransferase 1
type: ProteinReference
xref: Reference/UniProt P24173
organism: BiologicalState304

Lipopolysaccharide core heptose(I) kinase rfaP
type: ProteinReference
xref: Reference/UniProt P25741

Adenosine triphosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Adenosine triphosphate

ADP-heptose--LPS heptosyltransferase 2
type: ProteinReference
xref: Reference/UniProt P37692

Lipopolysaccharide 1,6-galactosyltransferase
type: ProteinReference
xref: Reference/UniProt P27127

Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
type: ProteinReference
xref: Reference/UniProt P27242

Reference/BioCyc CPD-8587
type: UnificationXref
id: CPD-8587
db: BioCyc

3-deoxy-manno-octulosonate cytidylyltransferase
type: ProteinReference
xref: Reference/UniProt P04951

SubPathway
type: Pathway
pathway order: SubPathwayInteractionSteps/SubPathway109920
pathway component: SubPathwayInteraction109920

Lipopolysaccharide core heptose(II) kinase rfaY
type: ProteinReference
xref: Reference/UniProt P27240

ChemicalStructure/PW C000969
type: ChemicalStructure
structure format: SMILES

Reference/ChEBI CHEBI 1146900
type: UnificationXref
id: CHEBI:1146900
db: ChEBI

Reference/KEGG Compound C06025
type: UnificationXref
id: C06025
db: KEGG Compound

Reference/ChEBI CHEBI 28645
type: UnificationXref
id: CHEBI:28645
db: ChEBI

myristoyl-[acp]
type: ProteinReference

Reference/PubChem-compound 46173153
type: UnificationXref
id: 46173153
db: PubChem-compound

DG(16:0/16:0)
type: SmallMoleculeReference
xref: Reference/HMDB HMDB0007098
xref: Reference/BioCyc DIACYLGLYCEROL
xref: Reference/KEGG Compound C00165
xref: Reference/CAS 30334-71-5
xref: Reference/ChEBI CHEBI 237189
xref: Reference/PubChem-compound 644078
xref: Reference/ChemSpider 559127
chemical formula: C35H68O5
molecular weight: 568.50665
structure: ChemicalStructure/PW C003149

Reference/CAS 30334-71-5
type: UnificationXref
id: 30334-71-5
db: CAS

Reference/ChEBI CHEBI 60364
type: UnificationXref
id: CHEBI:60364
db: ChEBI

Reference/CAS 14000-31-8
type: UnificationXref
id: 14000-31-8
db: CAS

Reference/ChEBI CHEBI 60365
type: UnificationXref
id: CHEBI:60365
db: ChEBI

Phosphate
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Phosphate

Lipopolysaccharide heptosyltransferase 1
type: Protein
cellular location: Cytosol
entity reference: Lipopolysaccharide heptosyltransferase 1

Reference/UniProt P10441
type: UnificationXref
id: P10441
db: UniProt

Reference/BioCyc CO-A
type: UnificationXref
id: CO-A
db: BioCyc

Compound/PW C000414 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine triphosphate
stoichiometric coefficient: 1.0

Reference/CAS 72-89-9
type: UnificationXref
id: 72-89-9
db: CAS

Reference/KEGG Compound C06026
type: UnificationXref
id: C06026
db: KEGG Compound

Reference/KEGG Compound C06398
type: UnificationXref
id: C06398
db: KEGG Compound

Coenzyme A
type: SmallMolecule
entity reference: Coenzyme A

Lipid A export ATP-binding/permease protein msbA
type: Protein
cellular location: Inner Membrane
entity reference: Lipid A export ATP-binding/permease protein msbA

Compound/PW C000196/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate-N-acetylglucosamine
stoichiometric coefficient: 1.0

Coenzyme A
type: SmallMoleculeReference
xref: Reference/ChEBI CHEBI 1146900
xref: Reference/HMDB HMDB0001423
xref: Reference/PubChem-compound 6816
xref: Reference/BioCyc CO-A
xref: Reference/ChemSpider 6557
xref: Reference/CAS 85-61-0
xref: Reference/KEGG Compound C00010
chemical formula: C21H36N7O16P3S
molecular weight: 767.11523
structure: ChemicalStructure/PW C001099

Adenosine diphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Adenosine diphosphate

dodecanoyl-[acp]
type: ProteinReference

Reference/UniProt P0ABZ4
type: UnificationXref
id: P0ABZ4
db: UniProt

Uridine triphosphate
type: SmallMolecule
cellular location: Cytosol
entity reference: Uridine triphosphate

Reference/UniProt P31120
type: UnificationXref
id: P31120
db: UniProt

Water
type: SmallMolecule
cellular location: Inner Membrane
entity reference: Water

Compound/PW C000196 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Uridine diphosphate-N-acetylglucosamine
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15422
type: UnificationXref
id: CHEBI:15422
db: ChEBI

Arabinose 5-phosphate isomerase
type: ProteinReference
xref: Reference/UniProt P45395

Reference/ChemSpider 6557
type: UnificationXref
id: 6557
db: ChemSpider

UDP-2,3-diacylglucosamine hydrolase
type: ProteinReference
xref: Reference/UniProt P43341
organism: BiologicalState304

Reference/CAS 13137-52-5
type: UnificationXref
id: 13137-52-5
db: CAS

Compound/PW C007308/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Arabinose 5-phosphate
stoichiometric coefficient: 1.0

outer membrane lipopolysaccharide transport and assembly complex - LptD subunit
type: Protein
entity reference: outer membrane lipopolysaccharide transport and assembly complex - LptD subunit

Escherichia coli
type: BioSource
xref: Reference/TAXONOMY 562

Phosphoglucosamine mutase
type: ProteinReference
xref: Reference/UniProt P31120

ChemicalStructure/PW C000940
type: ChemicalStructure
structure format: SMILES

DG(16:0/16:0)
type: SmallMolecule
entity reference: DG(16:0/16:0)

Reference/UniProt P43341
type: UnificationXref
id: P43341
db: UniProt

Compound/PW C001034 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Adenosine diphosphate
stoichiometric coefficient: 1.0

outer membrane lipopolysaccharide transport and assembly complex - LptE subunit
type: Protein
entity reference: outer membrane lipopolysaccharide transport and assembly complex - LptE subunit

ReactionCatalysis3008
type: Catalysis
controller: Lipopolysaccharide 1,3-galactosyltransferase
controlled: 2.4.1.44
control type: ACTIVATION

lipid IVA
type: SmallMolecule
cellular location: Cytosol
entity reference: lipid IVA

ReactionCatalysis3009
type: Catalysis
controller: Lipopolysaccharide 1,2-glucosyltransferase
controlled: 2.4.1.58
control type: ACTIVATION

ReactionCatalysis3006
type: Catalysis
controller: Lipopolysaccharide core heptose(II) kinase rfaY
controlled: 2.7.1.-
control type: ACTIVATION

ReactionCatalysis3007
type: Catalysis
controller: Lipopolysaccharide 1,6-galactosyltransferase
controlled: 2.4.1.-
control type: ACTIVATION

ReactionCatalysis3000
type: Catalysis
controller: Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase
controlled: 2.3.1.-
control type: ACTIVATION

ReactionCatalysis3001
type: Catalysis
controller: Lipopolysaccharide heptosyltransferase 1
controlled: 2.-.-.-
control type: ACTIVATION

ReactionCatalysis3004
type: Catalysis
controller: Lipopolysaccharide core heptose(I) kinase rfaP
controlled: 2.7.1.-
control type: ACTIVATION

Reference/PubChem-compound 439217
type: UnificationXref
id: 439217
db: PubChem-compound

ReactionCatalysis3005
type: Catalysis
controller: Lipopolysaccharide core heptosyltransferase rfaQ
controlled: 2.-.-.-
control type: ACTIVATION

ReactionCatalysis3002
type: Catalysis
controller: ADP-heptose--LPS heptosyltransferase 2
controlled: 2.-.-.-
control type: ACTIVATION

ReactionCatalysis3003
type: Catalysis
controller: Lipopolysaccharide core biosynthesis protein rfaG
controlled: 2.4.-.-
control type: ACTIVATION

L-Glutamic acid
type: SmallMoleculeReference
xref: Reference/PubChem-compound 33032
xref: Reference/ChEBI CHEBI 16015
xref: Reference/ChemSpider 30572
xref: Reference/HMDB HMDB0000148
xref: Reference/CAS 56-86-0
xref: Reference/BioCyc GLT
xref: Reference/KEGG Compound C00025
chemical formula: C5H9NO4
molecular weight: 147.05316
structure: ChemicalStructure/PW C000095

Water
type: SmallMolecule
cellular location: Cytosol
entity reference: Water

Reference/ChEBI CHEBI 61494
type: UnificationXref
id: CHEBI:61494
db: ChEBI

Reference/PubChem-compound 33032
type: UnificationXref
id: 33032
db: PubChem-compound

Protein/6211/Stoichiometry/3.0
type: Stoichiometry
physical entity: Bifunctional protein glmU
stoichiometric coefficient: 3.0

Compound/PW C001099/Stoichiometry/1.0
type: Stoichiometry
physical entity: Coenzyme A
stoichiometric coefficient: 1.0

Reference/HMDB HMDB0011734
type: UnificationXref
id: HMDB0011734
db: HMDB

Reference/BioCyc UDP-N-ACETYL-D-GLUCOSAMINE
type: UnificationXref
id: UDP-N-ACETYL-D-GLUCOSAMINE
db: BioCyc

Compound/PW C004971/Stoichiometry/1.0
type: Stoichiometry
physical entity: PE(16:0/16:0)
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16761
type: UnificationXref
id: CHEBI:16761
db: ChEBI

Compound/PW C000079/Stoichiometry/1.0
type: Stoichiometry
physical entity: Fructose 6-phosphate
stoichiometric coefficient: 1.0

Compound/PW C040987 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: heptosyl-Kdo2-lipid A
stoichiometric coefficient: 1.0

ReactionCatalysis3010
type: Catalysis
controller: Lipopolysaccharide 1,2-N-acetylglucosaminetransferase
controlled: 2.4.1.56
control type: ACTIVATION

Compound/PW C001420 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ReactionCoupledTransport164
type: TransportWithBiochemicalReaction
participant stoichiometry: Compound/PW C000079 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Compound/PW C000517 Inner Membrane/Stoichiometry/1.0
participant stoichiometry: Protein/7464 Inner Membrane/Stoichiometry/1.0
right: Fructose 6-phosphate
right: Phosphocarrier protein HPr
spontaneous: false
left: Phosphocarrier protein HPr
left: D-Fructose
name: D-Fructose + HPr - phosphorylated → Fructose 6-phosphate + HPr
conversion direction: LEFT_TO_RIGHT

Compound/PW C040979 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2,3-bis[(3R)-3-hydroxymyristoyl]-α-D-glucosaminyl 1-phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 15366
type: UnificationXref
id: CHEBI:15366
db: ChEBI

Reference/ChemSpider 389248
type: UnificationXref
id: 389248
db: ChemSpider

ADP-L-glycero-β-D-manno-heptose
type: SmallMoleculeReference
xref: Reference/KEGG Compound C06398
xref: Reference/ChEBI CHEBI 61506
chemical formula: C17H25N5O16P2
molecular weight: 617.07825
structure: ChemicalStructure/PW C040763

Compound/PW C000969/Stoichiometry/1.0
type: Stoichiometry
physical entity: Glucosamine 6-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 392413
type: UnificationXref
id: 392413
db: ChemSpider

UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
type: ProteinReference
xref: Reference/UniProt P21645

Compound/PW C001104/Stoichiometry/1.0
type: Stoichiometry
physical entity: Phosphate
stoichiometric coefficient: 1.0

Reference/ChEBI CHEBI 16695
type: UnificationXref
id: CHEBI:16695
db: ChEBI

3-deoxy-D-manno-octulosonic-acid transferase
type: Protein
cellular location: Cytosol
entity reference: 3-deoxy-D-manno-octulosonic-acid transferase

Compound/PW C040979/Stoichiometry/1.0
type: Stoichiometry
physical entity: 2,3-bis[(3R)-3-hydroxymyristoyl]-α-D-glucosaminyl 1-phosphate
stoichiometric coefficient: 1.0

Reference/ChemSpider 171
type: UnificationXref
id: 171
db: ChemSpider

Compound/PW C040993/Stoichiometry/1.0
type: Stoichiometry
physical entity: UDP-α-D-galactose
stoichiometric coefficient: 1.0

Compound/PW C040981 Cytosol/Stoichiometry/1.0
type: Stoichiometry
physical entity: lipid A disaccharide
stoichiometric coefficient: 1.0

Reference/CAS 923-61-5
type: UnificationXref
id: 923-61-5
db: CAS

Reference/ChEBI CHEBI 15377
type: UnificationXref
id: CHEBI:15377
db: ChEBI

Reference/ChEBI CHEBI 17677
type: UnificationXref
id: CHEBI:17677
db: ChEBI

Reference/ChEBI CHEBI 15378
type: UnificationXref
id: CHEBI:15378
db: ChEBI

ChemicalStructure/PW C040034
type: ChemicalStructure
structure format: SMILES
structure data: [H+]

ChemicalStructure/PW C000414
type: ChemicalStructure
structure format: SMILES

Reference/BioCyc ARABINOSE-5P
type: UnificationXref
id: ARABINOSE-5P
db: BioCyc

D-Arabinose 5-phosphate
type: SmallMoleculeReference
xref: Reference/PubChem-compound 188324
xref: Reference/CAS 13137-52-5
xref: Reference/HMDB HMDB0011734
xref: Reference/KEGG Compound C01112
xref: Reference/BioCyc ARABINOSE-5P
xref: Reference/ChemSpider 163687
xref: Reference/ChEBI CHEBI 16241
chemical formula: C5H11O8P
molecular weight: 230.01915
structure: ChemicalStructure/PW C007308

Reference/ChEBI CHEBI 71573
type: UnificationXref
id: CHEBI:71573
db: ChEBI

Reference/HMDB HMDB0000618
type: UnificationXref
id: HMDB0000618
db: HMDB

Compound/PW C001420/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

Reference/UniProt P21645
type: UnificationXref
id: P21645
db: UniProt

Compound/PW C040992/Stoichiometry/1.0
type: Stoichiometry
physical entity: glucosyl-(heptosyl)3-Kdo2-lipid A-bisphosphate
stoichiometric coefficient: 1.0

ReactionCatalysis3554
type: Catalysis
controller: D-fructose-6-phosphate aminotransferase
controlled: Reaction3565
control type: ACTIVATION

Reference/UniProt P0AC75
type: UnificationXref
id: P0AC75
db: UniProt

Reference/TAXONOMY 2
type: UnificationXref
id: 2
db: TAXONOMY

Protein/6697 Inner Membrane/Stoichiometry/2.0
type: Stoichiometry
physical entity: PTS system mannose-specific EIIAB component
stoichiometric coefficient: 2.0

Lipid-A-disaccharide synthase
type: ProteinReference
xref: Reference/UniProt P10441

ChemicalStructure/PW C000500
type: ChemicalStructure
structure format: SMILES
structure data: N[C@@H](CCC(N)=O)C(O)=O

Compound/PW C040739/Stoichiometry/1.0
type: Stoichiometry
physical entity: (KDO)2-(lauroyl)-lipid IVA
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000868
type: ChemicalStructure
structure format: SMILES

D-Arabinose 5-phosphate
type: SmallMolecule
entity reference: D-Arabinose 5-phosphate

Compound/PW C000479/Stoichiometry/1.0
type: Stoichiometry
physical entity: D-Ribulose 5-phosphate
stoichiometric coefficient: 1.0

Reference/UniProt P17169
type: UnificationXref
id: P17169
db: UniProt

Reference/PubChem-compound 1061
type: UnificationXref
id: 1061
db: PubChem-compound

Reference/CAS 63-39-8
type: UnificationXref
id: 63-39-8
db: CAS

Protein/Generic186/Stoichiometry/1.0
type: Stoichiometry
physical entity: myristoyl-[acp]
stoichiometric coefficient: 1.0

Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase
type: ProteinReference
xref: Reference/UniProt P24205

Reference/ChEBI CHEBI 15351
type: UnificationXref
id: CHEBI:15351
db: ChEBI

PTS system mannose-specific EIIAB component
type: Protein
cellular location: Inner Membrane
entity reference: PTS system mannose-specific EIIAB component

Compound/PW C001420 Inner Membrane/Stoichiometry/1.0
type: Stoichiometry
physical entity: Water
stoichiometric coefficient: 1.0

ChemicalStructure/PW C000517
type: ChemicalStructure
structure format: SMILES
structure data: OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O

Protein/6211 Cytosol/Stoichiometry/3.0
type: Stoichiometry
physical entity: Bifunctional protein glmU
stoichiometric coefficient: 3.0

Reference/PubChem-compound 176
type: UnificationXref
id: 176
db: PubChem-compound

Reference/HMDB HMDB0000641
type: UnificationXref
id: HMDB0000641
db: HMDB

Reference/UniProt P69801
type: UnificationXref
id: P69801
db: UniProt

phosphoethanolamine-Kdo2-lipid A
type: SmallMolecule
cellular location: Cytosol
entity reference: phosphoethanolamine-Kdo2-lipid A

Reference/CAS 85-61-0
type: UnificationXref
id: 85-61-0
db: CAS

Reference/UniProt P69805
type: UnificationXref
id: P69805
db: UniProt