CHEBI:50608
ChEBI
17215925
ChemSpider
6022
PubChem-compound
CHEBI:50606
ChEBI
937
ChemSpider
Riboflavin biosynthesis protein ribD
4.0
P25539
UniProt
431981
ChemSpider
GTP cyclohydrolase 1
1.0
SMILES
O
Endocytosis
SubPathway
Pyrophosphate
1.0
Transport486
false
FAD (→) Transport: Escherichia coli, Cytosol to Escherichia coli, Periplasmic Space
LEFT_TO_RIGHT
SMP0001985
SMPDB
HMDB0000538
HMDB
Uncharacterized transporter yeeO
ATP
BioCyc
H4N
Ammonium
18.034374
FAD
3.0
1.0
Riboflavin
559142
ChemSpider
P38038
UniProt
2.0
C17H20N4O6
Riboflavin
376.13828
ADP
BioCyc
1.0
1.0
5-Amino-6-(5'-phosphoribosylamino)uracil
53-59-8
CAS
CHEBI:16238
ChEBI
1.0
5742
ChemSpider
1038
PubChem-compound
439184
PubChem-compound
CHEBI:16474
ChEBI
HMDB0001520
HMDB
Sulfite reductase [NADPH] flavoprotein alpha-component
Riboflavin synthase alpha chain
FMN
BioCyc
GO:0005829
GENE ONTOLOGY
278
ChemSpider
CHEBI:15934
ChEBI
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase
O4P
Phosphate
94.95342
HMDB0003826
HMDB
NADPH
6830
PubChem-compound
1010
ChemSpider
1.0
NADP
PPI
BioCyc
C21H30N7O17P3
NADPH
745.0911
2,5-Diamino-6-(5'-phosphoribosylamino)-4-pyrimidineone
C21H29N7O17P3
NADP
744.08325
C9H16N5O8P
2,5-Diamino-6-(5'-phosphoribosylamino)-4-pyrimidineone
353.07364
Riboflavin biosynthesis protein ribF
riboflavin synthase
2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine
1.0
NADPH
BioCyc
Ammonium
C10H16N5O14P3
Guanosine triphosphate
522.99066
Hydrogen Ion
P0AFU8
UniProt
HMDB0011106
HMDB
FAD
Cytosol
3,4-Dihydroxy-2-butanone-4-P
218
ChemSpider
Sulfite reductase [NADPH] hemoprotein beta-component
NAD(P)H-flavin reductase
216
ChemSpider
Adenosine triphosphate
3,4-dihydroxy-2-butanone 4-phosphate synthase
HMDB0003841
HMDB
SMILES
[O-]P([O-])([O-])=O
HMDB0000217
HMDB
22833571
PubChem-compound
Formic acid
C00009
KEGG Compound
5118-16-1
CAS
C00008
KEGG Compound
CHEBI:18247
ChEBI
C00006
KEGG Compound
CHEBI:18009
ChEBI
C00001
KEGG Compound
HMDB0001429
HMDB
559059
ChemSpider
101652-10-2
CAS
5-Amino-6-(5'-phosphoribitylamino)uracil
CHEBI:18361
ChEBI
C00005
KEGG Compound
672
PubChem-compound
493570
PubChem-compound
CHEBI:18367
ChEBI
5-Amino-6-ribitylamino uracil
6,7-Dimethyl-8-(1-D-ribityl)lumazine
CPD-1086
BioCyc
1032
ChemSpider
GTP cyclohydrolase 1
326
ChemSpider
SMILES
CC(=O)C(O)COP(O)(O)=O
C00002
KEGG Compound
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
HMDB0000221
HMDB
559060
ChemSpider
HMDB0001557
HMDB
SMILES
NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O
1.0
Flavin Mononucleotide
C17H21N4O9P
Flavin Mononucleotide
456.1046
GTP cyclohydrolase I
CHEBI:18337
ChEBI
53-57-6
CAS
CPD-316
BioCyc
C27H33N9O15P2
FAD
785.1571
PW001971
PathWhiz
Uncharacterized transporter yeeO
C01342
KEGG Compound
C04732
KEGG Compound
CHEBI:28938
ChEBI
221
PubChem-compound
C00016
KEGG Compound
CHEBI:17363
ChEBI
C00013
KEGG Compound
C00255
KEGG Compound
2.5.1.9
false
2.5.1.9
1-Deoxy-L-glycero-tetrulose 4-phosphate + 5-Amino-6-ribitylamino uracil → 6,7-Dimethyl-8-(1-D-ribityl)lumazine + Hydrogen Ion + Phosphate + Water
LEFT_TO_RIGHT
O7P2
Pyrophosphate
173.91193
4.1.99.12
false
4.1.99.12
D-Ribulose 5-phosphate → 1-Deoxy-L-glycero-tetrulose 4-phosphate + Formic acid + Hydrogen Ion
LEFT_TO_RIGHT
NAD(P)
BioCyc
5957
PubChem-compound
GO:0005620
GENE ONTOLOGY
3.1.3.-
false
3.1.3.-
5-Amino-6-(5'-phosphoribitylamino)uracil + Water → 5-Amino-6-ribitylamino uracil + Phosphate
LEFT_TO_RIGHT
562
TAXONOMY
CHEBI:29114
ChEBI
H
Hydrogen Ion
1.007825
333
PubChem-compound
CHEBI:17015
ChEBI
C9H16N5O8P
2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine
353.07364
CHEBI:15996
ChEBI
C4H7O6P
3,4-Dihydroxy-2-butanone-4-P
181.99803
sulfite reductase
SMILES
OCC(=O)[C@H](O)[C@H](O)COP(O)(O)=O
56-65-5
CAS
Riboflavin synthase alpha chain
Guanosine triphosphate
SubPathwayOutput
Reaction5545
false
Guanosine triphosphate + Water → 2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + Formic acid + Hydrogen Ion + Pyrophosphate
LEFT_TO_RIGHT
HMDB0000244
HMDB
3.5.4.26
false
3.5.4.26
2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + Hydrogen Ion + Water → 5-Amino-6-(5'-phosphoribosylamino)uracil + Ammonium
LEFT_TO_RIGHT
Adenosine diphosphate
3.5.4.26
false
3.5.4.26
2,5-Diamino-6-(5'-phosphoribosylamino)-4-pyrimidineone + Hydrogen Ion + Water → 5-Amino-6-(5'-phosphoribosylamino)uracil + Ammonium
LEFT_TO_RIGHT
3.0
Riboflavin biosynthesis protein ribF
Reaction5548
false
5-Amino-6-(5'-phosphoribosylamino)uracil + Hydrogen Ion + NADPH → 5-Amino-6-(5'-phosphoribitylamino)uracil + NADP
LEFT_TO_RIGHT
1.0
C10H15N5O10P2
Adenosine diphosphate
427.02942
4151-19-3
CAS
DIMETHYL-D-RIBITYL-LUMAZINE
BioCyc
P0A7J0
UniProt
1.0
Reaction5542
false
Guanosine triphosphate + 3 Water → 2,5-Diamino-6-(5'-phosphoribosylamino)-4-pyrimidineone + Formic acid + 2 Hydrogen Ion + Pyrophosphate
LEFT_TO_RIGHT
1.0
CHEBI:17621
ChEBI
C01007
KEGG Compound
SMILES
CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)CO[P@](O)(=O)O[P@@](O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=NC(=O)NC(=O)C1=N2
CPD-8587
BioCyc
Water
ReactionCatalysis5525
ACTIVATION
652
ChemSpider
ReactionCatalysis5526
ACTIVATION
HMDB0000250
HMDB
ReactionCatalysis5524
ACTIVATION
SMILES
[O-]P([O-])(=O)OP([O-])([O-])=O
14000-31-8
CAS
HMDB0001341
HMDB
1.0
1.0
C00044
KEGG Compound
5675
ChemSpider
3,4-dihydroxy-2-butanone 4-phosphate synthase
3,4-dihydroxy-2-butanone 4-phosphate synthase
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
25244331
PubChem-compound
riboflavin synthase
1.0
6,7-dimethyl-8-ribityllumazine synthase
fused diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase
14798-03-9
CAS
18971002
PubChem-compound
SMILES
NC1=NC(N[C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)=C(N)C(=O)N1
2.5.1.9
false
2.5.1.9
6,7-Dimethyl-8-(1-D-ribityl)lumazine + Hydrogen Ion → 5-Amino-6-ribitylamino uracil + Riboflavin
LEFT_TO_RIGHT
2.7.1.26
false
2.7.1.26
Adenosine triphosphate + Riboflavin → Adenosine diphosphate + Flavin Mononucleotide + Hydrogen Ion
LEFT_TO_RIGHT
Reaction5565
false
Adenosine triphosphate + Flavin Mononucleotide + Hydrogen Ion → FAD + Pyrophosphate
LEFT_TO_RIGHT
HMDB0000142
HMDB
P0AG40
UniProt
CHEBI:17601
ChEBI
CHEBI:15422
ChEBI
669
PubChem-compound
643976
PubChem-compound
60.0
643975
PubChem-compound
C9H16N4O6
5-Amino-6-ribitylamino uracil
276.107
C13H18N4O6
6,7-Dimethyl-8-(1-D-ribityl)lumazine
326.12262
Escherichia coli
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase
riboflavin synthase
7732-18-5
CAS
C9H17N4O9P
5-Amino-6-(5'-phosphoribitylamino)uracil
356.0733
C00058
KEGG Compound
CH2O2
Formic acid
46.005478
83-88-5
CAS
HMDB0001248
HMDB
C00061
KEGG Compound
1.16.1.3
false
1.16.1.3
2 Hydrogen Ion + NADPH + Riboflavin → NADP + Riboflavin reduced
LEFT_TO_RIGHT
FORMATE
BioCyc
10.0
SMILES
NC1=C(N[C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)NC(=O)NC1=O
SMILES
[NH4+]
P0ADP0
UniProt
1.0
146-17-8
CAS
C10H16N5O13P3
Adenosine triphosphate
506.99576
2.0
CHEBI:16761
ChEBI
RIBOFLAVIN
BioCyc
SMILES
CC1=C(C)C=C2N(C[C@H](O)[C@H](O)[C@H](O)CO)C3=NC(=O)NC(=O)C3=NC2=C1
Riboflavin reduced
C15H16N4O6
Riboflavin reduced
348.107
P0A6T5
UniProt
Reaction5901
false
3,4-Dihydroxy-2-butanone-4-P + 5-Amino-6-ribitylamino uracil → 6,7-Dimethyl-8-(1-D-ribityl)lumazine + Phosphate + 2 Water
LEFT_TO_RIGHT
Riboflavin biosynthesis protein ribD
962
PubChem-compound
1.0
RIBULOSE-5P
BioCyc
5800
ChemSpider
439480
PubChem-compound
C00199
KEGG Compound
1-Deoxy-L-glycero-tetrulose 4-phosphate
SMILES
NC1=C(NCC(O)C(O)C(O)CO)NC(=O)NC1=O
Phosphate
1.0
SMILES
NC1=C(NCC(O)C(O)C(O)COP(O)(O)=O)NC(=O)NC1=O
C00080
KEGG Compound
CHEBI:30751
ChEBI
Periplasmic Space
HMDB0002111
HMDB
17216138
ChemSpider
SMILES
OC=O
C9H15N4O9P
5-Amino-6-(5'-phosphoribosylamino)uracil
354.05768
CHEBI:15377
ChEBI
SMILES
[H]C(O)([C@@]1([H])OC([H])(NC2=C(N)C(O)=NC(=N)N2)[C@]([H])(O)[C@]1([H])O)P(O)(O)=O
P76352
UniProt
146-14-5
CAS
CHEBI:15378
ChEBI
SMILES
[H+]
14265-44-2
CAS
C5H11O8P
D-Ribulose 5-phosphate
230.01915
SMILES
CC(=O)C(O)COP([O-])([O-])=O
6569
ChemSpider
58-64-0
CAS
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
5886
PubChem-compound
1.0
GTP
BioCyc
HMDB0000618
HMDB
SubPathwayInteraction112371
SubPathwayReaction
SubPathway112371Reaction
1.0
SMILES
OC[C@@H](O)[C@H](O)[C@H](O)CN1C2=CC=CC=C2N=C2C(=O)NC(=O)N=C12
1.0
439462
PubChem-compound
FAD
HMDB0001273
HMDB
644102
PubChem-compound
1.0
16741146
PubChem-compound
D-Ribulose 5-phosphate
1.0
P17846
UniProt
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
1.0
64-18-6
CAS
C04454
KEGG Compound
C04332
KEGG Compound
21983291
PubChem-compound
ReactionCatalysis5505
ACTIVATION
ReactionCatalysis5506
ACTIVATION
22833512
PubChem-compound
Sulfite reductase [NADPH] flavoprotein alpha-component
Flavin Biosynthesis
1.0
H2O
Water
18.010565
TransportCatalysis418
ACTIVATION
ReactionCatalysis5507
ACTIVATION
1.0
ReactionCatalysis5508
ACTIVATION
FAD
BioCyc
ReactionCatalysis5502
ACTIVATION
86-01-1
CAS
ReactionCatalysis5864
ACTIVATION
2.0
1061
PubChem-compound
HMDB0059597
HMDB
HMDB0041827
HMDB
P0AEN1
UniProt
C4H9O6P
1-Deoxy-L-glycero-tetrulose 4-phosphate
184.01367
NAD(P)H-flavin reductase
8.0
ReactionCatalysis5517
ACTIVATION
Sulfite reductase [NADPH] hemoprotein beta-component
ReactionCatalysis5878
ACTIVATION
2.0
ReactionCatalysis5877
ACTIVATION
SMILES
CC1=C(C)N(CC(O)C(O)C(O)CO)C2=NC(=O)NC(=O)C2=N1
ReactionCatalysis5519
ACTIVATION
ReactionCatalysis5512
ACTIVATION
SMILES
CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(O)=O)C1=NC(=O)NC(=O)C1=N2